Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Case report: Invasive neuromonitoring in status epilepticus induced hypoxic ischemic brain injury
We report a case of a 17 years-old male who was admitted to our hospital’s intensive care unit for RSE. HIBI was detected on neuroimaging on this patient’s second day of admission after he developed central diabetes insipidus (DI). Invasive neuromonitoring revealed raised intracranial pressure (ICP) and brain hypoxia as measured by reduced brain tissue oxygen tension (PbtO2). Treatments were escalated in a tiered fashion, including administration of hyperosmolar agents, analgesics, sedatives, and a neuromuscular blocking drug. Eventually, BDC was performed as a salvage therapy as a means of controlling refractory ICP...
Source: Frontiers in Neurology - November 30, 2023 Category: Neurology Source Type: research
Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia
Am Fam Physician. 2023 Nov;108(5):476-486.ABSTRACTHyponatremia and hypernatremia are electrolyte disorders that can be associated with poor outcomes. Hyponatremia is considered mild when the sodium concentration is 130 to 134 mEq per L, moderate when 125 to 129 mEq per L, and severe when less than 125 mEq per L. Mild symptoms include nausea, vomiting, weakness, headache, and mild neurocognitive deficits. Severe symptoms of hyponatremia include delirium, confusion, impaired consciousness, ataxia, seizures, and, rarely, brain herniation and death. Patients with a sodium concentration of less than 125 mEq per L and severe sym...
Source: American Family Physician - November 20, 2023 Category: Primary Care Authors: Nathaniel E Miller David Rushlow Stephen K Stacey Source Type: research
Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia
Am Fam Physician. 2023 Nov;108(5):476-486.ABSTRACTHyponatremia and hypernatremia are electrolyte disorders that can be associated with poor outcomes. Hyponatremia is considered mild when the sodium concentration is 130 to 134 mEq per L, moderate when 125 to 129 mEq per L, and severe when less than 125 mEq per L. Mild symptoms include nausea, vomiting, weakness, headache, and mild neurocognitive deficits. Severe symptoms of hyponatremia include delirium, confusion, impaired consciousness, ataxia, seizures, and, rarely, brain herniation and death. Patients with a sodium concentration of less than 125 mEq per L and severe sym...
Source: American Family Physician - November 20, 2023 Category: Primary Care Authors: Nathaniel E Miller David Rushlow Stephen K Stacey Source Type: research
Hyperintensity in Bilateral Posterior Limbs of Internal Capsule Due to Hypernatremia
CONCLUSION: This case report extends the spectrum of classical osmotic demyelination in clinical manifestations, image findings, and the causal range of electrolyte derangements.PMID:37968847 (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - November 16, 2023 Category: Neurology Authors: Min-Yang Wu Yuan-Ting Sun Source Type: research
Herpes Simplex Virus Diencephalitis Leading to Panhypopituitarism
JCEM Case Rep. 2023 Jun 8;1(3):luad050. doi: 10.1210/jcemcr/luad050. eCollection 2023 May.ABSTRACTHerpes simplex virus (HSV) is one of the most common causes of viral encephalitis. Hypothalamic-pituitary dysfunction has rarely been reported in HSV encephalitis, with few reports into the longer term outcomes for these patients. A 46-year-old male presented with a 10-day history of delirium, fever, and polydipsia. Initial computed tomography of the brain and cerebrospinal fluid cell counts were normal. Magnetic resonance imaging showed T2-hyperintensity affecting bilateral infundibuli, hypothalami, subthalamic nuclei, and op...
Source: Herpes - November 1, 2023 Category: Infectious Diseases Authors: Caoimhe Casey Antoinette O'Connor Simon Cronin Antoinette Tuthill Source Type: research
Healthcare disparities in pituitary surgery: a systematic review
CONCLUSIONS: This study revealed the presence of disparities in pituitary adenoma surgery based on race, SES, age, and gender. These disparities highlight the need for further research and interventions to ensure equitable access to appropriate surgical treatment and improved outcomes for all patients with pituitary adenomas.PMID:37913542 | DOI:10.3171/2023.8.FOCUS23467 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - November 1, 2023 Category: Neurosurgery Authors: Mohammadmahdi Sabahi Seyed Farzad Maroufi Adrianna Wierzbicka Lana Maniakhina Badih Adada Hamid Borghei-Razavi Source Type: research
Herpes Simplex Virus Diencephalitis Leading to Panhypopituitarism
JCEM Case Rep. 2023 Jun 8;1(3):luad050. doi: 10.1210/jcemcr/luad050. eCollection 2023 May.ABSTRACTHerpes simplex virus (HSV) is one of the most common causes of viral encephalitis. Hypothalamic-pituitary dysfunction has rarely been reported in HSV encephalitis, with few reports into the longer term outcomes for these patients. A 46-year-old male presented with a 10-day history of delirium, fever, and polydipsia. Initial computed tomography of the brain and cerebrospinal fluid cell counts were normal. Magnetic resonance imaging showed T2-hyperintensity affecting bilateral infundibuli, hypothalami, subthalamic nuclei, and op...
Source: Herpes - November 1, 2023 Category: Infectious Diseases Authors: Caoimhe Casey Antoinette O'Connor Simon Cronin Antoinette Tuthill Source Type: research
Healthcare disparities in pituitary surgery: a systematic review
CONCLUSIONS: This study revealed the presence of disparities in pituitary adenoma surgery based on race, SES, age, and gender. These disparities highlight the need for further research and interventions to ensure equitable access to appropriate surgical treatment and improved outcomes for all patients with pituitary adenomas.PMID:37913542 | DOI:10.3171/2023.8.FOCUS23467 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - November 1, 2023 Category: Neurosurgery Authors: Mohammadmahdi Sabahi Seyed Farzad Maroufi Adrianna Wierzbicka Lana Maniakhina Badih Adada Hamid Borghei-Razavi Source Type: research
Healthcare disparities in pituitary surgery: a systematic review
CONCLUSIONS: This study revealed the presence of disparities in pituitary adenoma surgery based on race, SES, age, and gender. These disparities highlight the need for further research and interventions to ensure equitable access to appropriate surgical treatment and improved outcomes for all patients with pituitary adenomas.PMID:37913542 | DOI:10.3171/2023.8.FOCUS23467 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - November 1, 2023 Category: Neurosurgery Authors: Mohammadmahdi Sabahi Seyed Farzad Maroufi Adrianna Wierzbicka Lana Maniakhina Badih Adada Hamid Borghei-Razavi Source Type: research
Healthcare disparities in pituitary surgery: a systematic review
CONCLUSIONS: This study revealed the presence of disparities in pituitary adenoma surgery based on race, SES, age, and gender. These disparities highlight the need for further research and interventions to ensure equitable access to appropriate surgical treatment and improved outcomes for all patients with pituitary adenomas.PMID:37913542 | DOI:10.3171/2023.8.FOCUS23467 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - November 1, 2023 Category: Neurosurgery Authors: Mohammadmahdi Sabahi Seyed Farzad Maroufi Adrianna Wierzbicka Lana Maniakhina Badih Adada Hamid Borghei-Razavi Source Type: research
Healthcare disparities in pituitary surgery: a systematic review
CONCLUSIONS: This study revealed the presence of disparities in pituitary adenoma surgery based on race, SES, age, and gender. These disparities highlight the need for further research and interventions to ensure equitable access to appropriate surgical treatment and improved outcomes for all patients with pituitary adenomas.PMID:37913542 | DOI:10.3171/2023.8.FOCUS23467 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - November 1, 2023 Category: Neurosurgery Authors: Mohammadmahdi Sabahi Seyed Farzad Maroufi Adrianna Wierzbicka Lana Maniakhina Badih Adada Hamid Borghei-Razavi Source Type: research
