Panhypopituitarism, Diabetes Insipidus and Bone Pain - Is There a Systemic Disease Behind it?
Praxis (Bern 1994). 2024 Jan;113(1):23-26.ABSTRACTA 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made.PMID:38381107 (Source: Praxis)
Source: Praxis - February 21, 2024 Category: General Medicine Authors: Martina Bertschinger Lisa Sze Irene Bosma Corina Dommann-Scherrer Jeroen Goede Source Type: research
Panhypopituitarism, Diabetes Insipidus and Bone Pain - Is There a Systemic Disease Behind it?
Praxis (Bern 1994). 2024 Jan;113(1):23-26.ABSTRACTA 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made.PMID:38381107 (Source: Praxis)
Source: Praxis - February 21, 2024 Category: General Medicine Authors: Martina Bertschinger Lisa Sze Irene Bosma Corina Dommann-Scherrer Jeroen Goede Source Type: research
Panhypopituitarism, Diabetes Insipidus and Bone Pain - Is There a Systemic Disease Behind it?
Praxis (Bern 1994). 2024 Jan;113(1):23-26.ABSTRACTA 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made.PMID:38381107 (Source: Praxis)
Source: Praxis - February 21, 2024 Category: General Medicine Authors: Martina Bertschinger Lisa Sze Irene Bosma Corina Dommann-Scherrer Jeroen Goede Source Type: research
Long-term outcomes and potential predictive recurrence factors after endonasal endoscopic surgical treatment of symptomatic Rathke ’s cleft cysts
AbstractAlthough patients with symptomatic Rathke ’s cleft cysts (RCCs) receive surgical treatment, recurrence sometimes occurs after surgery. However, the mechanism underlying recurrence remains unclear. We evaluated the outcomes of RCC decompression over a long-term follow-up period. We retrospectively reviewed the medical records of 35 patient s with symptomatic RCC who underwent endonasal endoscopic surgery (EES) at our institution between 2008 and 2023. Patients’ characteristics, intraoperative findings, and postoperative follow-up outcomes were evaluated. A univariate regression model was used to identify the pre...
Source: Neurosurgical Review - February 17, 2024 Category: Neurosurgery Source Type: research
Endoscopic endonasal transsphenoidal surgery for unusual sellar lesions: eight cases and review of the literature
ConclusionOur study retrospectively analyzed eight unusual lesions of the sellar region. Some lesions exhibit specific imaging characteristics and clinical details that can aid in preoperative diagnosis and inform treatment strategies for these unusual sellar diseases. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 13, 2024 Category: Neurology Source Type: research
Diabetes insipidus: vasopressin deficiency …
Ann Endocrinol (Paris). 2024 Feb 3:S0003-4266(24)00011-8. doi: 10.1016/j.ando.2023.11.006. Online ahead of print.ABSTRACTDiabetes insipidus is a disorder characterized by hypo-osmotic polyuria secondary to abnormal synthesis, regulation, or renal action of antidiuretic hormone. Recently, an expert group, with the support of patient associations, proposed that diabetes insipidus be renamed to avoid confusion with diabetes mellitus. The most common form of diabetes insipidus is secondary to a dysfunction in the neurohypophysis (central diabetes insipidus) and would be therefore termed 'vasopressin deficiency'. The rarer form...
Source: Annales d'Endocrinologie - February 5, 2024 Category: Endocrinology Authors: Fanny Chasseloup Antoine Tabarin Philippe Chanson Source Type: research
Risk Factors for Development of Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone Secretion after Transsphenoidal Resection of Pituitary Adenoma
Conclusion DI and SIADH occur in the minority of patients undergoing TSH, but vigilance for their development must be maintained for days after the surgery. Development of DI after TSH is multifactorial, having possible patient-specific risk factors and risk related to the complexity of surgical dissection, reflected by tumor size, intraoperative CSF leak, and EBL. Development of SIADH could be associated with intraoperative CSF leak occurrence. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neu...
Source: Journal of Neurological Surgery Part B: Skull Base - February 2, 2024 Category: Neurosurgery Authors: Petito, Gabrielle Hu, Alex Zhang, Grace Min, Susie Tripathi, Siddhant H. Kumar, Adithya Shukla, Geet Shah, Sanjit Phillips, Katie M. Jana, Suman Forbes, Jonathan A. Zuccarello, Mario Andaluz, Norberto O. Sedaghat, Ahmad R. Tags: Original Article Source Type: research
Prediction of diabetes insipidus occurrence after endoscopic endonasal removal of sellar lesions using MRI-based radiomics and machine learning
CONCLUSIONS: We assessed the accuracy of machine learning analysis of texture-derived parameters from preoperative MRI of pituitary adenomas and craniopharyngiomas for the prediction of DI occurrence.PMID:38287775 | DOI:10.23736/S0390-5616.23.06162-3 (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - January 30, 2024 Category: Neurosurgery Authors: Ciro Mastantuoni Lorenzo Ugga Domenico Solari Serena D'Aniello Gaia Spadarella Renato Cuocolo Filippo F Angileri Luigi M Cavallo Source Type: research
Highlights from the literature
Langerhans cell histiocytosis (LCH) It’s rare, but it is there, and will need to be considered in your differential diagnoses on a few occasions in a general paediatrician’s career. Lucina’s most recent experience has been with the common presentation of polydipsia and polyuria and an ultimate diagnosis of central diabetes insipidus (CDI) caused by LCH. Alexander A and Zacharin M [J Paediatr and Child Health 2023 https://doi.org/10.1111/jpc.16521] have documented the incidence of endocrine features in paediatric patients with LCH from one tertiary endocrine centre in Victoria, Australia. Using a simple re...
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research
Targeted long-read sequencing identified a causal structural variant in X-linked nephrogenic diabetes insipidus
X-linked nephrogenic diabetes insipidus (NDI) is a rare genetic renal disease caused by pathogenic variants in the AVPR2 gene. Single nucleotide variants and small insertions/deletions in AVPR2 are reliably detec... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - January 22, 2024 Category: Genetics & Stem Cells Authors: Luk áš Strych, Monika Černá, Markéta Hejnalová, Tomáš Zavoral, Pavla Komrsková, Jitka Tejcová, Ibrahim Bitar, Eva Sládková, Josef Sýkora and Ivan Šubrt Tags: Research Source Type: research
Transient Central Diabetes Insipidus (Arginine Vasopressin Deficiency) Following SARS-CoV-2 Vaccination: A Case Report and Literature Review
CONCLUSION: Neurohypophysitis can have an abrupt onset independently of the etiology. Central DI is a rather exceptional event after SARS-CoV-2 vaccination but should be recalled in case of sudden polyuria and polydipsia. DI is indeed reported even after SARS-CoV-2 infection, thus, this report should not discourage the use of mRNA-based vaccines. Furthermore, our case demonstrates that full recovery of posterior pituitary function is possible after immunization with anti-Covid-19 BNT162b2 vaccine. Further studies are needed to clarify the possible mechanism relating to SARS-CoV-2 vaccination and this rare adverse event.PMI...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 20, 2024 Category: Endocrinology Authors: Pierluigi Mazzeo Filippo Ceccato Renzo Manara Cinzia Mazzon Mattia Barbot Source Type: research
Transient Central Diabetes Insipidus (Arginine Vasopressin Deficiency) Following SARS-CoV-2 Vaccination: A Case Report and Literature Review
CONCLUSION: Neurohypophysitis can have an abrupt onset independently of the etiology. Central DI is a rather exceptional event after SARS-CoV-2 vaccination but should be recalled in case of sudden polyuria and polydipsia. DI is indeed reported even after SARS-CoV-2 infection, thus, this report should not discourage the use of mRNA-based vaccines. Furthermore, our case demonstrates that full recovery of posterior pituitary function is possible after immunization with anti-Covid-19 BNT162b2 vaccine. Further studies are needed to clarify the possible mechanism relating to SARS-CoV-2 vaccination and this rare adverse event.PMI...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 20, 2024 Category: Drugs & Pharmacology Authors: Pierluigi Mazzeo Filippo Ceccato Renzo Manara Cinzia Mazzon Mattia Barbot Source Type: research
Optochiasmatic Cavernomas: Updated systematic review and proposal of a novel classification with surgical approaches
AbstractCavernomas are histologically benign vascular malformations found at different sites in the brain. A rare site for such cavernomas, however, is the anterior optic pathway, comprising the optic nerve, chiasma, and optic tract —called optochiasmatic cavernomas (OCC). These lesions usually present with sudden onset or progressive vision loss, headache, and features mimicking pituitary apoplexy. In this paper, we describe a case of OCC operated at our center. We carry out an updated review of literature depicting cases of OCC, their clinical presentation, management, and postoperative complications. We also propose a...
Source: Neurosurgical Review - January 19, 2024 Category: Neurosurgery Source Type: research
Pituitary metastasis arising from hepatocellular carcinoma: a case report and update of the literature
Z Gastroenterol. 2024 Jan 15. doi: 10.1055/a-2225-5057. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the sixth most common neoplasia and the third leading cause of cancer-associated deaths worldwide. Most cases arise in patients with cirrhosis, and early detection through periodic screening can make it potentially curable. The presence of extrahepatic metastases (EHM) affects treatment decisions and curability. The lungs are the most common site for EHM, followed by lymph nodes, bones, and the adrenal glands. Interestingly, approximately only 15 cases of HCC metastasizing to the pituitary gland have been...
Source: Zeitschrift fur Gastroenterologie - January 15, 2024 Category: Gastroenterology Authors: Isaac Rodriguez Lena Vogel Constantin Dreher Asan Cherkezov Frank Giordano Matthias Fr ölich Matthias Philip Ebert Andreas Teufel Judit Boda-Heggemann Source Type: research
Pituitary Adenoma Coexistent with Sellar Clear Cell Meningioma Unattached to the Dura: Case Report and Treatment Considerations
J Neurol Surg Rep 2024; 85: e1-e10 DOI: 10.1055/s-0043-1777792Collision tumors involving the sella are rare. Intrasellar collision tumors are most commonly composed of a combination of pituitary adenomas and pituitary neuroendocrine tumors; however, collision tumors consisting of a pituitary adenoma and intrasellar meningioma are exceedingly rare. The authors present the case of a 47-year-old man who presented with progressive right eye vision loss. Magnetic resonance imaging showed a large, heterogeneously enhancing sellar mass with suprasellar extension. Using a transcranial approach with a right subfrontal craniotomy, n...
Source: Journal of Neurological Surgery Reports - January 9, 2024 Category: Neurosurgery Authors: Chatain, Gr égoire P. Chee, Keanu Driscoll, Meghan Kleinschmidt-DeMasters, B.K. Lillehei, Kevin O. Tags: Case Report Source Type: research
