Fight Aging! Newsletter, December 30th 2019

This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR improved cell growth and proliferation by promoting entry of cell cycles from the G0 or G1 phase to S/G2-M phase. Most importantly, BBR extended the lifespan of chemotherapy-treated mice and naturally aged mice by ~52% and ~16.49%, respectively. The residual lifespan of the naturally aged mice was extended by 80%, from 85.5 days to 154 days. The oral administration of BBR in mice resulted in significantly improved health span, fur density, and behavioral activity. Therefore, BBR may be an ideal candidate for the development of an anti-aging medicine. Genetic Variants are not an Important Risk Factor in the Vast Majority of People and Age-Related Conditions https://www.fightaging.org/archives/2019/12/genetic-variants-are-not-an-important-risk-factor-in-the-vast-majority-of-people-and-age-related-conditions/ This is an age of ge...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Conclusions: Nutrition counseling was rarely documented in a large sample of electronic medical record (EMR) data from pediatric wellness visits in South Carolina-a state heavily burdened by childhood obesity. Children's BMIs were infrequently recorded, which may be a barrier to tracking BMI over time. Sociodemographic and geographic differences in nutrition counseling may exacerbate disparities in childhood obesity. PMID: 32960095 [PubMed - as supplied by publisher]
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Publication date: Available online 21 September 2020Source: European Journal of RadiologyAuthor(s): Ana I. Garcia Diez, David Fuster, Laura Morata, Ferran Torres, Ruben Garcia, Daniel Poggio, Santiago Sotes, Montserrat Del Amo, Jaime Isern-Kebschull, Jaume Pomes, Alex Soriano, Laura Brugnara, Xavier Tomas
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: December 2020Source: Social Science &Medicine, Volume 266Author(s): Trang Thu Do, Andrea Whittaker
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
You could consider this a follow-up to one of last week’s posts: Are You Most Loyal to Purpose or People? I want to share another way of framing the mindset of being loyal to purpose ahead of people, especially for those who’d prefer to shift into greater loyalty to purpose. Putting purpose first isn’t dehumanizing if you frame it a certain way – if your purpose actually involves serving people. If, however, your purpose is mainly self-centered, like if it’s based on individual achievements that will be of little or no benefit to others, then I think you’re more likely to run in...
Source: Steve Pavlina's Personal Development Blog - Category: Psychiatry & Psychology Authors: Tags: Abundance Values Source Type: blogs
Getting the right care in a timely manner is important in medical emergencies. In the event that you or a loved one suffers a stroke, time is especially critical. “In the event of a stroke, a delay of only 15 minutes in treatment greatly decreases your chances not only of making a full recovery, but also being able to walk or live independently, and in many cases, of survival,” says Christopher Zammit, MD, a critical care specialist and emergency physic ian with TriHealth, which offers a network…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Publication date: November 2020Source: Human Pathology: Case Reports, Volume 22Author(s): Shohei Matsuo, Yoshitane Tsukamoto, Eiichiro Mabuchi, Shunichi Negoro, Seiichi Hirota
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Publication date: Available online 22 September 2020Source: Pathology - Research and PracticeAuthor(s): Yasamin Pahlavan, Mina Mohammadi Nasr, Elaheh Dalir Abdolahinia, Zahra Pirdel, Saiedeh Razi Soofiyani, Samaneh Siahpoush, Kazem Nejati
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 21 September 2020Source: Pathology - Research and PracticeAuthor(s): He Zhang, Yi Wang, Yanfeng Wang, Daoyuan Wu, Enguang Lin, Qingxin Xia
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Abstract Even though bariatric surgery is one of the most effective treatment option of obesity, post-surgical weight loss is not always ensured, especially in the long term, when many patients experience weight regain. Bariatric procedures are largely based on surgeon's expertise and intra-operative decisions, while an integrated in-silico approach could support surgical activity. The effects of bariatric surgery on gastric distension, which activates the neural circuitry promoting satiety, can be considered one of the main factors in the operation success. This aspect can be investigated trough computational mod...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract The mechanical properties of biologic scaffolds are critical to cellular interactions and hence functional response within the body. In the case of scaffolds for bone tissue regeneration, engineered scaffolds created by combining collagen with inorganic mineral are increasingly being explored, due to their favourable structural and chemical characteristics. Development of a method for controlling the mechanics of these scaffolds could lead to significant additional advantages by harnessing the intrinsic mechnotransduction pathways of stem cells via appropriate control of scaffold mechanical properties. He...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
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