Fight Aging! Newsletter, December 30th 2019

This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR improved cell growth and proliferation by promoting entry of cell cycles from the G0 or G1 phase to S/G2-M phase. Most importantly, BBR extended the lifespan of chemotherapy-treated mice and naturally aged mice by ~52% and ~16.49%, respectively. The residual lifespan of the naturally aged mice was extended by 80%, from 85.5 days to 154 days. The oral administration of BBR in mice resulted in significantly improved health span, fur density, and behavioral activity. Therefore, BBR may be an ideal candidate for the development of an anti-aging medicine. Genetic Variants are not an Important Risk Factor in the Vast Majority of People and Age-Related Conditions https://www.fightaging.org/archives/2019/12/genetic-variants-are-not-an-important-risk-factor-in-the-vast-majority-of-people-and-age-related-conditions/ This is an age of ge...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors.The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)2}]. The structures of all mixes were completely portrayed by spectroscopic techniques (1H-NMR, 13C{1H} NMR , IR and elemental and further analyzed by DFT/...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
CONCLUSION: PSs represent a potential tool to treat this form of breast cancer by providing peptides that may be useful in therapy. PMID: 32065785 [PubMed - in process]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
ConclusionThe practice of health promotion behaviour varies among patients, individually tailored interventions and motivation is needed.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Hombaiah Chandana, B. Madhu, M.R. Narayana MurthyAbstractIntroductionGlobally, cervical cancer is the 4th most common cancer and is one of the leading cancers causing death in India. Cervical cancer is one of those cancers which can be easily prevented by screening women who are aged above 30 years and by vaccinating young girls against HPV. Lack of awareness about cervical cancer makes early detection and timely screening difficult. Awareness about cervical cancer among people will help us to decide on an appropria...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Conclusions3D printed stem cells seem to have extensive applications in regenerative medicine for the treatment of various diseases. These cells help seed decellularisation of complete organs for regenerative medicine. This technology also applies to the reconstruction of heart valves and has excellent potential in valvular disease. These cells have higher capabilities to fulfil different medical requirements, but it is challenging to steer its growth as per the need of human kind. Scientists created 3D printed stem cells structure which can grow, and they have performed tissue regeneration experiments on them. Traditional...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionsOur findings support measurement invariance of the EORTC QLQ-C30 in a large sample of patients with hematological malignancies. The results showed that the number of non-invariant items was negligible, suggesting that this questionnaire is a valid and robust measurement tool in patients with hematological malignancies, also for comparisons across groups and time.
Source: Quality of Life Research - Category: Health Management Source Type: research
Whiplash injuries account for approximately 70% of all injuries leading to disability, induced by modern vehicle crashes. Females are at greater risk for sustaining whiplash injuries than males, which may be attributable to differences in the physiology of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
If you want to be a doctor, hold off on medical school until age 28 - STAT There are advantages to spending your formative years working at a first career and meeting your life partner, and then starting medical school at age 28. www.statnews.com "Every generation of physicians must be free to act for itself. Claims to a physician’s 20s have withered away. Corporate health care has deemed physicians replaceable, either by those who accept lower pay or by... STAT: Why Medical School Should Start at 28...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
ConclusionThe association of antibiotic and surgical therapy seems to be more effective compared to each one alone. The lack of comparison studies and randomized controlled trials makes it difficult to give information about the efficacy of the different management therapies.
Source: The Surgeon - Category: Surgery Source Type: research
This article outlines the components of the interlinked endocrine, metabolic, immune and haemodynamic responses and discusses the ways in which the various components of the response can be modified in order to optimize postoperative recovery and to reduce complications. The role of vitamin supplementation and the controversial element of glucocorticoids is also discussed.
Source: Surgery (Oxford) - Category: Surgery Source Type: research
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