NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance Antonio Lucena-Cacace1, Masayuki Umeda1, Lola E. Navas2,3 and Amancio Carnero2,3* 1Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan 2CIBERONC, ISCIII, Madrid, Spain 3Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío (HUVR), CSIC, Universidad de Sevilla, Sevilla, Spain Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable of initiating new tumors contributing to Glioma progression, maintenance, hierarchy, and complexity. GSCs are highly resistant to chemo and radiotherapy. These cells are believed to be responsible for tumor relapses and patients' fatal outcome after developing a recurrent Glioblastoma (GBM) or High Grade Glioma (HGG). GSCs are cells under replicative stress with high demands on NAD+ supply to repair DNA, maintain self-renewal capacity and to induce tumor plasticity. NAD+ feeds Poly-ADP polymerases (PARP) and NAD+-dependent deacetylases (SIRTUINS) contributing to GSC phenotype. This energetic core axis is mainly controlled by the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), an important oncogene contributing to tumor dedifferentiation. Targeting GSCs depicts a new frontier in Glioma therapy; hence NAMPT could represent a key regulator for GS...
Authors: Brand C, Sehn AP, Gaya AR, Mota J, Brazosayavera J, Pollo Renner JD, Reuter CP Abstract PURPOSE: To verify the moderator role of physical fitness in the relationship betweenadiposity and cardiometabolic risk factors in normal weight and overweight/obese children and adolescents. METHODS: Cross-sectional study comprising 2482 children and adolescents, aged 7-17 years. Physical fitness was evaluated according the procedures of Projeto Esporte Brazil, and waist circumference (WC) with an inelastic tape. Cardiometabolic risk score was defined by the z-score sum of glucose, total cholesterol, high-density l...
CONCLUSIONS: This study demonstrated that CSR and CSS were not statistically different when determined with different predictive trials located within the recommended durations of 2-12 min. Nevertheless, CSR200-800 and CSS200-800 exhibited the best consistency with CSR200-400-800 and CSS200-400-800, respectively. PMID: 32614153 [PubMed - as supplied by publisher]
Publication date: August 2020Source: Biomedical Signal Processing and Control, Volume 61Author(s): Yasir Islam, Iftikhar Ahmad, Muhammad Zubair, Khurram Shahzad
Authors: Latha S, Selvamani P, Prabha T Abstract Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various pu...
Publication date: Available online 3 July 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Melisa J. Andrade, Kapaettu Satyamoorthy, Zee Upton, Derek R. Van Lonkhuyzen
Publication date: Available online 3 July 2020Source: European UrologyAuthor(s): Giuseppe Di Lorenzo, Riccardo Autorino
Publication date: Available online 3 July 2020Source: European UrologyAuthor(s): Christian D. Fankhauser, Kathryn L. Penney, Amparo G. Gonzalez-Feliciano, Noel W. Clarke, Thomas Hermanns, Konrad H. Stopsack, Michelangelo Fiorentino, Massimo Loda, Brandon Mahal, Travis A. Gerke, Mark A. Preston, Lorelei A. Mucci
Publication date: Available online 3 July 2020Source: European UrologyAuthor(s): David E. Neal, Chris Metcalfe, Jenny L. Donovan, J. Athene Lane, Michael Davis, Grace J. Young, Susan J. Dutton, Eleanor I. Walsh, Richard M. Martin, Tim. J. Peters, Emma L. Turner, Malcolm Mason, Richard Bryant, Prasad Bollina, James Catto, Alan Doherty, David Gillatt, Vincent Gnanapragasam, Peter Holding, Owen Hughes
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Carlo A. Bravi, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Daniele Robesti, Daniar Osmonov, Klaus-Peter Juenemann, Luca Boeri, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Alessandro Nini, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Shahrokh F. Shariat
Publication date: Available online 2 July 2020Source: European UrologyAuthor(s): Alexandre R. Zlotta, Sigrid V. Carlsson, Antonio Finelli, Neil E. Fleshner
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