NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives
Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies.
(GSCs) are a small subset of CD133+ cells with self-renewal properties and capable of initiating new tumors contributing to Glioma progression, maintenance, hierarchy and complexity. GSCs are highly resistant to chemo and radiotherapy. These cells are believed to be responsible for tumor relapses and patients' fatal outcome after developing a recurrent GBM or High Grade Glioma (HGG). GSCs are cells under replicative stress with high demands on NAD+ supply to repair DNA, maintain self-renewal capacity and to induce tumor plasticity. NAD+ feeds Poly-ADP polymerases (PARP) and NAD+-dependent deacetylases (SIRTUINS) contributing to GSC phenotype. Ablation of NAMPT showed to impair Schwann cell differentiation program associated to reduced NAD+ levels, counteracting the phenotype found in tumor cells but reinforcing the idea that an adequate NAD...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Addiction | Amnesia | Anemia | Astrocytoma | Ataxia | Avastin | Biochemistry | Biology | Brain | Brain Cancers | Brain Tumor | Breast Cancer | Breast Carcinoma | Calcium | Cancer | Cancer & Oncology | Carcinoma | Chancroid | Chemistry | Chemotherapy | Chronic Leukemia | Chronic Lymphocytic Leukemia | Clinical Trials | Colon Cancer | Colorectal Cancer | Diets | Eating Disorders & Weight Management | Economy | Endometrial Cancer | Gastric (Stomach) Cancer | Gastroenterology | Gastroschisis Repair | Genetics | Glioma | Grants | Hematology | Hepatocellular Carcinoma | Hodgkin's Disease | Insulin | International Medicine & Public Health | Ischemic Stroke | Japan Health | Leiomyosarcoma | Leukemia | Liver | Liver Cancer | Lymphoma | Macroglobulinemia | Melanoma | Men | Mitochondria | Mitochondrial Disease | Molecular Biology | Myeloma | Nanotechnology | Neurology | Neuroscience | Neurosurgery | Niacin | Niaspan | Nursing | Nutrition | Obesity | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Primary CNS Lymphoma | Radiation Therapy | Respiratory Medicine | Rhabdomyosarcoma | Science | Skin Cancer | Spain Health | Sports Medicine | Stem Cell Therapy | Stem Cells | Stroke | Study | Sugar | T-cell Lymphoma | Temodar | Thyroid | Thyroid Cancer | Toxicology | Urology & Nephrology | Velcade | Verapamil | Vitamin B3 | Vitamins | Waldenstrom's Macroglobulinemia | WHO | Zinc