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Isoptin SR (Verapamil Hydrochloride Tablet) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 22, 2017 Category: Drugs & Pharmacology Source Type: news

Can a blood pressure pill really cure a runny nose?
In a U.S. trial, verapamil reduced sniffles in those suffering from chronic sinusitis — which affects one in six people. Sinusitis develops when the nasal passages and the lining of the sinuses get inflamed. (Source: the Mail online | Health)
Source: the Mail online | Health - February 20, 2017 Category: Consumer Health News Source Type: news

Covera-HS (Verapamil) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 31, 2017 Category: Drugs & Pharmacology Source Type: news

Patients with severe chronic rhinosinusitis show improvement with Verapamil treatment
A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 23, 2017 Category: Science Source Type: news

Patients with severe chronic rhinosinusitis show improvement with Verapamil treatment
(Massachusetts Eye and Ear Infirmary) A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients. The clinical trial results suggest that Verapamil represents a promising novel therapy for the treatment of CRS with nasal polyps. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 23, 2017 Category: Global & Universal Source Type: news

Verelan (Verapamil Hydrochloride) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Calan SR (Verapamil Hydrochloride Sustained-Release Oral Caplets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 8, 2016 Category: Drugs & Pharmacology Source Type: news

Calan (Verapamil HCl) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 7, 2016 Category: Drugs & Pharmacology Source Type: news

Calcium channel blockers caught in the act at atomic level
(University of Washington Health Sciences/UW Medicine) Atomic level analysis has revealed how two classes of calcium channel blockers, widely prescribed for heart disease patients, produce separate therapeutic effects by acting at different sites on the calcium channel molecule. The study looked at the anti-arrhythmia drug verapamil, and the hypertension and angina drug amlodipine. The study was conducted on bacterial calcium channels, which respond to these cardiovascular medicines. The findings could inform the design of better, safer calcium channel blockers for heart beat irregularities, chest pain, and high blood pres...
Source: EurekAlert! - Biology - August 24, 2016 Category: Biology Source Type: news

Striking increases in postmortem compared to antemortem drug concentrations in a suicidal overdose: a case report - McIntyre IM, Mallett P, Stolberg S, Haas EA, Mena O.
Toxicology testing revealed dramatic increases in whole-blood concentrations of verapamil and diphenhydramine in the short time between hospital admission and death (53 min) in a subject (with a history of overdosing) found unresponsive. While some degree ... (Source: SafetyLit)
Source: SafetyLit - August 12, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Tarka (Trandolapril and Verapamil ER) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 25, 2016 Category: Drugs & Pharmacology Source Type: news

Do you know the answer to this tough USMLE Step 2 question?
If you’re gearing up to take the United States Medical Licensing Examination® (USMLE®) Step 2, get this month’s exclusive scoop on the most missed USMLE Step 2 test prep question and expert strategies to help you master it. Think you have what it takes to rise above your peers? Test your USMLE knowledge, and view an expert video explanation of the answer from Kaplan Medical. Once you’ve got this question under your belt, be sure to test your knowledge with other posts in this series. Ready. Set. Go. This month’s question that stumped most students: A 57-year-old female with a his...
Source: AMA Wire - April 28, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news

Type 1 Diabetes Cure?
BIRMINGHAM, Ala. (Ivanhoe Newswire) -- A medication called Verapamil is a common treatment for controlling blood pressure, but researchers have stumbled onto another possible use for it: curing type-one diabetes. A first-of-its-kind trial is now underway, and it could be the cure for what is currently the seventh leading cause of death in the U.S. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - March 15, 2016 Category: Consumer Health News Source Type: news

First Human Data Show Verapamil Lowers Glucose in DiabetesFirst Human Data Show Verapamil Lowers Glucose in Diabetes
Early research hints that this old antihypertensive drug may also lower serum glucose, especially in patients with type 1 or late-stage type 2 diabetes who are on insulin. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - February 29, 2016 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Diabetics who use verapamil have lower glucose levels, data show
While causal relationship cannot be inferred, findings of a new study are “absolutely encouraging," says the lead author of a new report. The study shows for the first time that there is an association of verapamil use and lower fasting glucose levels in humans with diabetes (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 12, 2016 Category: Science Source Type: news

Verapamil Hydrochloride (Verapamil Hydrochloride Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 22, 2016 Category: Drugs & Pharmacology Source Type: news

verapamil (Calan, Verelan, Verelan PM [Discontinued: Isoptin, Isoptin SR, Covera-HS])
Title: verapamil (Calan, Verelan, Verelan PM [Discontinued: Isoptin, Isoptin SR, Covera-HS])Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 10/13/2015 12:00:00 AM (Source: MedicineNet Cholesterol General)
Source: MedicineNet Cholesterol General - October 13, 2015 Category: Cardiology Source Type: news

TPR Podcast Episode #8: Pearls from NACCT
Discussion of Dr. Millard Bass’ JAMA article “Sudden Sniffing Death” (SSD) SSD occurs after sniffing, bagging, or huffing a volatile hydrocarbon inhalant Hypothesis: death results from sensitization of the myocardium to catecholamines, resulting in cardiac arrhythmias   Capsaicin for Cannabinoid Hyperemesis Syndrome Initial idea to use capsaicin in the treatment of cannabinoidhyperemesis syndrome (CHS) stemmed from: Symptomatic relief from hot showers or baths often reported by patients Realization that TRPV1 receptor is activated by both hot temperatures and capsaicin Case reports from Calif...
Source: The Poison Review - March 1, 2015 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast cannabinoid hyperemesis syndrome capsaicin cream clenbuterol NACCT phenibut sudden sniffing death syndrome tpr podcast Source Type: news

Glenmark gets USFDA nod to sell generic blood pressure drug Tarka
The approval for trandolapril and verapamil hydrochloride extended release tablets has been granted to Glenmark Generics Inc. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 26, 2015 Category: Pharmaceuticals Source Type: news

Diabetes Discovery: Heart Drug Spares Beta Cells In Lab
(MedPage Today) -- Can verapamil preserve beta cell function in type 1 diabetes? (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 20, 2015 Category: Cardiology Source Type: news

Whole bowel irrigation? Don’t just do something, stand there!
3.5 out of 5 stars Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Thanacoody R et al. Clin Toxicol 2015 Jan;53:5-12. Abstract In 1997 the American Academy of Clinical Toxicology (AACT) and the Euroopean Association of Poisons Centre and Clinical Toxicologists (EAPCCT) published a position paper regarding the use of whole bowel irrigation (WBI) for gastrointestinal decontamination in the poisoned patient. The key conclusions were that no evidence existed showing that WBI improved clinical outcome, and that it should not be used routinely but “may be consid...
Source: The Poison Review - January 13, 2015 Category: Toxicology Authors: Leon Tags: Medical gastrointestinal decontamination overdose poisoning polyethylene glycol position paper whole bowel irrigation Source Type: news

New treatment strategy allows lower doses of toxic tuberculosis drug without compromising potency
While an effective treatment is available for combating multidrug-resistant tuberculosis, it carries serious side effects for patients. New research shows that lower doses of the toxic drug bedaquiline — given together with verapamil, a medication that’s used to treat various heart conditions — can lead to the same antibacterial effects as higher toxic doses of bedaquiline. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 30, 2014 Category: Science Source Type: news

New treatment strategy allows lower doses of toxic tuberculosis drug without compromising potency
(Johns Hopkins Medicine) While an effective treatment is available for combating multidrug-resistant tuberculosis, it carries serious side effects for patients. New research conducted at the Center for Tuberculosis Research at the Johns Hopkins University School of Medicine shows that lower doses of the toxic drug bedaquiline -- given together with verapamil, a medication that's used to treat various heart conditions -- can lead to the same antibacterial effects as higher toxic doses of bedaquiline. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 30, 2014 Category: Infectious Diseases Source Type: news

Verapamil Hope for Reversal of Type 1 DiabetesVerapamil Hope for Reversal of Type 1 Diabetes
A first-of-its kind trial in patients with type 1 diabetes will attempt to reverse the disease process by increasing beta-cell mass using a common blood-pressure-lowering pill. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - November 6, 2014 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Acute respiratory distress syndrome following intralipid emulsion therapy
2.5 out of 5 stars Acute respiratory distress syndrome following verapamil overdose treated with intravenous lipid emulsion; A rare life-threatening complication. Martin C et al.  Ann Fr Anesth Reanim 2014 [Epub ahead of print] Reference This interesting French case report is a textbook example of how not to use intralipid emulsion therapy (ILE) in calcium-channel-block (CCB) overdose. It describes a 51-year-old woman who present to the emergency room 8 hours after ingesting forty 240 mg verapamil, a total of 9.6 grams. She was hypotensive and bradycardic, although alert and oriented. Initial echocardiograph...
Source: The Poison Review - July 12, 2014 Category: Toxicology Authors: Leon Tags: Medical adverse drug reaction calcium channel blocker overdose intralipid emulsion therapy verapamil Source Type: news

trandolapril/verapamil extended-release - oral, Tarka
Title: trandolapril/verapamil extended-release - oral, TarkaCategory: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 4/16/2014 12:00:00 AM (Source: MedicineNet High Blood Pressure General)
Source: MedicineNet High Blood Pressure General - April 16, 2014 Category: Cardiology Source Type: news

Do two dissimilar cases represent a case series?
2 out of 5 stars High-dose Insulin and Intravenous Lipid Emulsion Therapy for Cardiogenic Shock Induced by Intentional Calcium-Channel Blocker and Beta-Blocker Overdose: A Case Series. Doepker B et al. J Emerg Med 2014 Apr;46:486-490.   Abstract The problems with this confused and confusing paper start with the title, which suggests that it will describe a series patients who presented with overdose of a calcium-channel blocker (CCB) and beta-blocker (BB), who were treated with high-dose insulin (HDI) and intravenous lipid emulsion (ILE). Well, this may be a case series, but the series includes only 2 patien...
Source: The Poison Review - April 3, 2014 Category: Toxicology Authors: Leon Tags: Medical beta blocker overdose calcium channel blocker overdose high-dose insulin intralipid intravenous fat emulsion Source Type: news

The Top 7 Tox Articles of 2013
As we celebrate the year just ending, and welcome in 2014, let’s pause and remember some of the articles in the field of medical toxicology that most impressed TPR during 2013. The following 7 papers are listed in chronological order (links connect to TPR‘s discussion of each article): Pediatric Marijuana Exposures in a Medical Marijuana State. Wang GS et al. JAMA Pediatr 2013 July;167:630-3 With several states legalizing recreational marijuana — and many more allowing medical marijuana — cases of inadvertent pediatric exposure to cannabis will undoubtedly increase, and it is important for emergenc...
Source: The Poison Review - December 31, 2013 Category: Toxicology Authors: Leon Tags: Medical 2013 medical toxicology top articles Source Type: news

Calan SR (Verapamil Hydrochloride Sustained-Release Oral Caplets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 3, 2013 Category: Drugs & Pharmacology Source Type: news

Lipid rescue therapy can cause lab errors
3 out of 5 stars Caution with interpreting laboratory results after lipid rescue therapy. Punja M et al. Am J Emerg Med 2013 Aug 8 [Epub ahead of print] No abstract available This short case report from Emory University and the Georgia Poison Center makes the point that administering lipid rescue therapy (LRT) may affect laboratory results in ways that may be unanticipated. In the case, a 54-year-old man who ingested a mixed overdose of diphenhydramine, amitriptyline and acetaminophen. His initial aspartate aminotransferase level (measured on a Siemens Vista 1500 analyzer) was 138 U/L. After 20% IV lipids were given, ...
Source: The Poison Review - August 22, 2013 Category: Toxicology Authors: Leon Tags: Medical aspartate aminogransferase AST erroneous lab values laboratory error lipid rescue therapy Source Type: news

Why Shouldn't I Drink Grapefruit Juice With My...
Any number of medications can apply to this question: Prozac, BuSpar, Tegretol, Verapamil, Prednisone and a host of others - even Viagra! There are a large number of other medications affected by grapefruit juice as well, including all the cholesterol-lowering statins and even some antibiotics and birth control pills. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 21, 2013 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What are the Recommendations for Neuromaging Because of Headaches?
Discussion Headaches are not only painful but can significantly affect the lives of patients and families. Education and support for patients is key to managing headaches. Detailed diaries not only help with initial diagnosis but also chronic management. Common headache types include: Tension headache Location – bilateral Intensity – mild or moderate Description – non-pulsating tightening or pressure Activities – not aggravated by usual activities Duration – 30 minutes – continuous Frequency – 15 days per month for more than 3 months for chronic tension headache Treatment &ndash...
Source: PediatricEducation.org - July 15, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Pressors or high-dose insulin for calcium channel blocker overdose?
4 out of 5 stars What Is the Best Treatment for Acute Calcium Channel Blocker Overdose? Olson KR. Ann Emerg Med 2013 Apr 5 [Epub ahead of print] Abstract This excellent editorial is a comment on the paper by Levine et al, “Critical Care Management of Verapamil and Diltiazem Overdose with a Focus on Vasopressors: A 25-year Experience at a Single Center”. In that paper, which TPR reviewed last month, the authors advocated that fluids and vasopressors should be first-line treatment for hypotension and shock caused by overdose or verapamil or diltiazem, with high-dose insulin/euglycemia 9HIE) therapy...
Source: The Poison Review - June 21, 2013 Category: Toxicology Authors: Leon Tags: Medical calcium channel blocker overdose diltiazem high-dose insulin norepinephrine shock vasopressors verapamil Source Type: news

Are vasopressors effective therapy in calcium channel blocker overdose?
4 out of 5 stars Critical Care Management of Verapamil and Diltiazem Overdose with a Focus on Vasopressors: A 25-Year Experience at a Single Center. Levine M et al. Ann Emerg Med 2013 May 1 {Epub ahead of print] Abstract This uncommonly interesting and thought-provoking study comes from the Department of Medical Toxicology at Banner Good Samaritan Medical Center in Phoenix. The authors note that in recent years, many toxicologists have suggested that hyperinsulinemic euglycemic therapy (HIT) is superior to vasopressors in the treatment of calcium channel blocker (CCB) toxicity. However, there have been no studies...
Source: The Poison Review - May 18, 2013 Category: Toxicology Authors: Leon Tags: Best of TPR Medical calcium channel blocker toxicity diltiazem hyperinsulinemic euglycemic therapy verapamil Source Type: news

The many potential problems with using dabigatran
3.5 out of 5 stars Dabigatran: Uncharted Waters and Potential Harms. Radecki RP. Ann Intern Med 2012;157:66-68. No abstract available The Institute for Safe Medication Practices has reported that soon after its approval in October 2010,  the oral direct thrombin inhibitor dabigatran etexilate (Pradaxa) was associated with a higher incidence of adverse events than almost any other drug. In this opinion piece, Ryan Radecki — curator and author  of the essential blog Emergency Medicine Literature of Note — reviews some of the factors contributing to this alarming alarming associa...
Source: The Poison Review - January 23, 2013 Category: Toxicology Authors: Leon Tags: Medical adverse effects complications dabigatran pradaxa Source Type: news