Fight Aging! Newsletter, June 27th 2016

In conclusion, we showed for the first time that 7-KC induces oxidative stress via lysosomal dysfunction, resulting in exacerbation of calcification. CHIMERIC ANTIGEN RECEPTOR CANCER THERAPIES CAN NOW TARGET SOLID TUMORS https://www.fightaging.org/archives/2016/06/chimeric-antigen-receptor-cancer-therapies-can-now-target-solid-tumors/ If the research community is to win in the fight to cure cancer, and win soon enough to matter for all of us, then the focus must be on technology platforms that can be easily and cheaply adapted to many different types of cancer. The biggest strategic problem in the field is that most of the expensive, time-consuming efforts to develop new therapies are only applicable to one or a few of the hundreds of types of cancer. Immunotherapies based on the use of chimeric antigen receptors are an incremental step towards solving this problem, an improvement on the present situation because this technology may cut the cost of tailoring an immunotherapy to each specific type of cancer. This approach has worked very well in trials targeting leukemia, but there was some question as to how to adapt it for use in solid tumors, and whether it would work in this context. Fortunately, it seems that this next step forward has now been accomplished, at least in a preliminary animal study: Chimeric antigen receptor (CAR) T cell therapy, which edits a cancer patient's T cells to recognize their tumors, has successfully helped patients with agg...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 19 October 2019Source: Biosensors and BioelectronicsAuthor(s): Xumei Zhou, Wen Zhang, Zhen Wang, Jing Han, Gang Xie, Sanping ChenAbstractIn this work, a high-efficiency electrochemiluminescence (ECL) ternary system was constructed for ultrasensitive assay of insulin based on hollow porous graphitic carbon nitride (HP–C3N4) as novel luminophore, S2O82− as coreactant and tri-metallic AuPtAg as coreaction accelerator. Specifically, in comparison with C3N4-based bulk nanomaterials, the as-prepared HP-C3N4 exhibits high luminous efficiency though decreased inner filter effect and m...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Yu Yang, Jiang-Yu Bian, Yu-Han Li, Hui-Chao Guan, Yan-Ru Tang, Yan-Ling Chen, Shu-Mei YueAbstractSix complexes including [Cd (bpt)(odc)2] (1), [Ni(bpt)(odc)2] (2), [Zn (bpt)(odc)2] (3), [Zn (bpt)(1,4-ndc)2(H2O)] (4), [Cd (bpt)(1,4-ndc)2] (5), [Cd (bpt)(Pta)2(H2O)2] (6), {bpt = 2-(2 pyridyl)benzothiazole, H2odc = 4,4′-oxybisbenzoic acid, 1,4-H2ndc = naphthalene-1,4-dicarboxylic acid, Pta = terephthalic acid}, have been determined by single-crystal X-ray diffraction analysis, which shows that complexes 1&ndas...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, Malathy P. ShekharAbstractTriple negative breast cancer (TNBC) is an aggressive breast cancer subtype with few therapy options besides chemotherapy. Although platinum-based drugs have shown initial activity in BRCA1-mutated TNBCs, chemoresistance remains a challenge. Here we show that RAD6B (UBE2B), a principal mediator of translesion synthesis (TLS), is overexpressed in BRCA1 wild-type and mutant TNBCs, and RAD6B overexpression correlate...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
CONCLUSION: Collectively, our results suggest that HIF-1α participates in the inflammatory response process caused by Ang II and that downregulation of HIF-1α may be able to partially protect or reverse inflammatory injury in podocytes. PMID: 31623681 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
In this study, we exposed wild-type (WT) and AMPKα2−/− mice to PM2.5 every other day via intratracheal instillation for 4 weeks. After PM2.5 exposure, the AMPKα2−/− mice developed more severe lung injury and cardiac dysfunction than were developed in the WT mice; however the administration of metformin was effective in attenuating PM2.5-induced lung injury and cardiac dysfunction in both the WT and AMPKα2−/− mice. In the PM2.5-exposed mice, metformin treatment resulted in reduced systemic and pulmonary inflammation, preserved left ventricular ejection fraction, suppress...
Source: Redox Biology - Category: Biology Source Type: research
In this study, we compared differences in gene expression in parental and CHD4-deficient cells by next-generation sequencing and Ingenuity Pathway Analysis.Key findingsWe found that β1 integrin is a downstream target gene of CHD4, which could be transcriptionally regulated by CHD4 in TNBC cells. Consistent with in vitro data, immunohistochemistry revealed that co-expression of β1 integrin and CHD4 was significantly associated with metastatic state, recurrence, and survival status in TNBC patients. It also showed a positive correlation between β1 integrin and CHD4 in vivo.SignificanceThis is the first study t...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Life SciencesAuthor(s): Chao Liu, Jiao SunAbstractAimsThe reciprocity between stem cells and biomaterials is an essential topic in bone tissue engineering. Bone marrow mesenchymal stromal cells (BMSCs) have attracted considerable attention in regenerative medicine owing to their ability to self-renew and differentiate into osteoblasts, and more importantly, their immunomodulatory effects on the immune response. Ideal biomaterials should be osteo-inductive, environmentally sustainable, and economical. Our previous study showed that hydrolyzed fish collagen (HFC) can ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Life SciencesAuthor(s): Lu Fu, Fang Rao, Feihong Lian, Hui Yang, Sujuan Kuang, Shulin Wu, Chunyu Deng, Yumei XueAbstractAimsTo explore the atrial electrical remodeling and the susceptibility of atrial fibrillation (AF) in diabetic rats.Materials and methodsZucker diabetic fatty (ZDF) rats were chosen as diabetic animal model, and age-matched non-diabetic littermate Zucker lean (ZL) rats as control. AF susceptibility was determined by electrophysiological examination. The current density of Ito, IKur and ICa-L were detected by whole-cell patch-clamp technique, and io...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Life SciencesAuthor(s): Jawad Ali, Ashraf Ullah Khan, Fawad Ali Shah, Hussain Ali, Salman Ul Islam, Yeong Shik Kim, Salman KhanAbstract5-Fluorouracil (5-FU)-induced intestinal mucositis (IM) is one of the most common oncological problem. It involves serious clinical consequences such as diarrhea, erythematous lesions of mucosa, and eventually development of ulcers accompanied by severe pain. The aim of the present study was to demonstrate the mucoprotective effects of Saikosaponin-A in 5-FU-induced intestinal mucositis in mice. Mucositis was induced in BALB/c mice b...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Life SciencesAuthor(s): Swati Gupta, Gurudutta GangenahalliAbstractAimEndothelial cell damage is critical to understand since its presence in the entire body makes the damage widespread instead of being localized. Being a major component of stem cell niche in bone marrow, deems it essential to gain knowledge of the damage to endothelium associated with bone marrow. Since radiation exposure has become common to numerous therapeutic modalities, its effects on bone marrow and its endothelial cells are crucial to understand.Material &methodsMicroarray analysis was p...
Source: Life Sciences - Category: Biology Source Type: research
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