Fight Aging! Newsletter, December 18th 2023

In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team. « Back to Top Aged Transplant Organs Cause Harm to Younger Recipients https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/ Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent measures of aging and means to treat aging, there was little to be done about it and arguably more pressing logistical issues to focus on. Times change, however. A growing appreciation of the role of senescent cells in degenerative aging, and the ability to clear some fraction of these cells via senolytic therapies such as the dasatinib and quercetin combination, has given the research, medical, and industry communities involved in organ transplant a novel approach to improve the quality of transplanted organs and outcomes for patients. Most organ transplantations involve supply from older donors to younger recipients. Aging cells can become senescent, a condition in which they stop multiplying and secrete chemicals that negatively affect neighboring cells. Senescent cells accumulate in older donor organs, and have the potential to compromise transpla...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs