Fight Aging! Newsletter, August 21st 2023

This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., frailty index ≥0.25) than in non-frail participants. This study shows the association between serum CAP2 concentration and frailty status for the first time, highlighting the potential of CAP2 as a biomarker for age-associated accumulation of deficits. « Back to Top Immune Function as an Important Mediator of the Benefits of Calorie Restriction https://www.fightaging.org/archives/2023/08/immune-function-as-an-important-mediator-of-the-benefits-of-calorie-restriction/ Calorie restriction is the practice of adopting up to a 40% reduction in calorie intake versus an ad libitum diet, while still obtaining optimal micronutrient levels. It is perhaps the most studied of all interventions known to slow aging and extend healthy life span in short-lived species, but equally there is still much that we do not know about how i...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs