Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced insulin/IGF-1 signaling.
Transplantion of Glial Progenitor Cells Regenerates Myelin in a Mouse Model of Multiple Sclerosis
https://www.fightaging.org/archives/2020/06/transplantion-of-glial-progenitor-cells-regenerates-myelin-in-a-mouse-model-of-multiple-sclerosis/
Disabling conditions result when the myelin sheathing of nerves is sufficiently degraded, such as via a malfunctioning immune system attacking the body's own tissues, as is the case for multiple sclerosis. All of us suffer loss of myelin with aging to some degree however, due to damage and dysfunction in the oligodendrocyte cell populations responsible for maintaining myelin. There is evidence for this specific issue to contribute to age-related cognitive decline. Thus treatments that focus on boosting remyelination are of general interest: if safe, they should probably be appl...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
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