Fight Aging! Newsletter, November 18th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Poor Results from an Initial Human Trial of Nicotinamide Mononucleotide How to Start a Biotech Company in the Longevity Industry Cellular Senescence is Important in Zebrafish Fin Regrowth An Interview with Matthew O'Connor, as Underdog Pharmaceuticals Secures Seed Funding Notes on the 2019 Longevity Week Events in London The MicroRNA mir-83 Disrupts Autophagy in Aging Nematode Worms Cardiovascular Aging Contributes to Brain Aging Selectively Removing Mutant Proteins by Binding them to Autophagy Components Greater Waist Circumference, Greater Risk of Dementia Delivery of MALAT1 in Exosomes as a Treatment for Osteoporosis Senescent Cells Mediate the Incidence of Periodontitis in Diabetic Patients Rapamycin Prevents Deterioration in Brain Circulation in Aged Rats The Gut ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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In this study we explored the use of a natural compound rubusoside (RUB) as a solubilizer to enhance the solubility of a fluorescence-labeled C6-Ceramide (NBD C6-Ceramide) and to characterize its pharmacokinetics and tissue distribution in an animal model. RUB significantly enhanced the solubility of NBD C6-Ceramide by forming nanomicelles, and efficiently delivered NBD C6-Ceramide in rats by oral and intravenous administration. RUB loaded 1.96% of NBD C6-Ceramide in the nanomicelles and solubilized it to a concentration of 3.6 mg/mL in water. NBD C6-Ceramide in nanomicelles remained stable in aqueous solutions, all...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Authors: Atzema CL, Jackevicius CA, Chong A, Dorian P, Ivers NM, Parkash R, Austin PC Abstract BACKGROUND: Patients with atrial fibrillation frequently seek emergency care. Rates of guideline-concordant oral anticoagulant therapy for stroke prevention are suboptimal in the community. We assessed the association between prescribing of oral anticoagulants in the emergency department (relative to referral to a longitudinal care provider for treatment initiation) and long-term use of oral anticoagulants. METHODS: This retrospective cohort study performed at 15 hospitals in Ontario, Canada, involved patients aged 65...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Food Composition and AnalysisAuthor(s): Afsaneh Mohajer, Abbas Norouzian Baghani, Parisa Sadighara, Kiandokht Ghanati, Shahrokh NazmaraAbstractIn this current study, the contents of heavy metals including Pb, As, Cr, Cd, Zn, Cu, and Mn in imported rice bran oil in Iran were investigated with microwave digestion method based on an inductively coupled plasma optical emission spectrometry system (ICP-OES). The concentrations range of Pb, Cr, Cd, As, Zn, and Cu in rice bran oil samples were measured as 0.066 - 0.30, 0.008 - 0.014, 0.005 - 0.01, 0.047- 0.01, ...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
In this study, the effects of the addition of various polysaccharides (konjac gum, gellan gum, and curdlan gum) on the rheological and textural properties of calcium sulfate-induced soy protein isolate gels were investigated. The incorporation of konjac gum and curdlan gum at 0.3 and 0.5% (w/v) concentrations and gellan gum at 0.5% concentration significantly enhanced (P 
Source: Food Chemistry - Category: Food Science Source Type: research
In this study, a fluorescence biosensor based on the peroxidase mimicking activity of platinum nanoparticles (Pt NPs) was fabricated for rapid detection of hypoxanthine (Hx), which is a sensitive indicator of the freshness of aquatic products. The fluorescence intensity of the sensing system had a linear relationship with the concentration of Hx in the range of 8–2500 μM, and the limit of detection was as low as 2.88 μM (S/N = 3). Moreover, benefiting from the excellent selectivity of the biosensor, Hx content in fish, shrimp and squid samples could be quickly detected with good recovery rat...
Source: Food Chemistry - Category: Food Science Source Type: research
The objective of this study was to investigate the nutritional functions of highland barley subjected to heat-moisture treatment (HMT) and dry heat treatment (DHT) in vitro and in vivo. In vitro test indicated HMT and DHT play part in the reduced glycemic potency of highland barley. Meanwhile, in vivo results showed that thermally-processed highland barley (THB) supplementation significantly decreased the body weight and serum glucose, improved oxidation resistance and altered the composition of gut microbiota. Bifidobacteria, Fusicatenibacter and Desulfovibrio were identified as types of bacteria that might related to the...
Source: Food Chemistry - Category: Food Science Source Type: research
Authors: Santarosa C, Cord B, Koo A, Bhogal P, Malhotra A, Payabvash S, Minja FJ, Matouk CC Abstract Intracranial high-resolution vessel wall magnetic resonance imaging is an imaging paradigm that complements conventional imaging modalities used in the evaluation of neurovascular pathology. This review focuses on the emerging utility of vessel wall magnetic resonance imaging in the characterization of intracranial aneurysms. We first discuss the technical principles of vessel wall magnetic resonance imaging highlighting methods to determine aneurysm wall enhancement and how to avoid common interpretive pitfalls. We...
Source: Interventional Neuroradiology - Category: Radiology Tags: Interv Neuroradiol Source Type: research
Publication date: Available online 10 December 2019Source: Small Ruminant ResearchAuthor(s): J. Reintke, K. Brügemann, H. Wagner, P. Engel, A. Wehrend, S. KönigAbstractThere is an increasing economic pressure in sheep production. Hence, it is imperative to use all available tools contributing to improvements in lamb survival. In this regard, there is a lack of studies addressing the impact of maternal body condition traits on lamb performances during lactation. Specifically, the focus of the present study was to analyse associations between ewe traits reflecting maternal energy metabolism and lamb body weight (LB...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Authors: Hill BG, Shiva S, Ballinger S, Zhang J, Darley-Usmar VM Abstract It is now becoming clear that human metabolism is extremely plastic and varies substantially between healthy individuals. Understanding the biochemistry that underlies this physiology will enable personalized clinical interventions related to metabolism. Mitochondrial quality control and the detailed mechanisms of mitochondrial energy generation are central to understanding susceptibility to pathologies associated with aging including cancer, cardiac and neurodegenerative diseases. A precision medicine approach is also needed to evaluate the ...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Authors: Aretz I, Jakubke C, Osman C Abstract Mitochondria supply virtually all eukaryotic cells with energy through ATP production by oxidative phosphoryplation (OXPHOS). Accordingly, maintenance of mitochondrial function is fundamentally important to sustain cellular health and various diseases have been linked to mitochondrial dysfunction. Biogenesis of OXPHOS complexes crucially depends on mitochondrial DNA (mtDNA) that encodes essential subunits of the respiratory chain and is distributed in multiple copies throughout the mitochondrial network. During cell division, mitochondria, including mtDNA, need to be ac...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
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