How a mom ’s determination – and a UCLA transplant – saved her daughter’s life
It started with a bad cold. It was December 2022, and 4-year-old Raylee Osuna had a cough, stuffy nose and a slight fever. Even though she seemed better after a few days, her mom, Klarissa Hope, had a sense that something was still off.  Several weeks later and despite several medical appointments, Raylee still hadn ’t fully bounced back. On Christmas morning, she looked pale, and Hope brought her to urgent care near their home in Ontario to request that bloodwork and other tests be done. At that point, none of Raylee ’s results showed any cause for concern. “They all kept telling me it was just a virus,” Hope sa...
Source: UCLA Newsroom: Health Sciences - May 9, 2024 Category: Universities & Medical Training Source Type: news

What is the Dose-Response for Maternal Vitamin D Supplementation in Lactating Mothers?
Discussion Vitamin D is an important vitamin for bone formation and mineral homeostasis. Hypocalcemia, hypophosphatemia, osteomalacia, rickets and tetany can all result because of Vitamin D deficiency. Deficiency is caused by inadequate dietary intakes of Vitamin D, inadequate exposure to sunlight or patients with fat malabsorption or renal disease. Even in high sun exposure areas of the world, Vitamin D deficiency can occur because of inadequate exposure due to clothing or cultural practices. Sunscreen blocks sunlight and an SPF (sun protection factor) of 8 blocks 95% of the sun, so there needs to be a careful balance bet...
Source: PediatricEducation.org - April 15, 2024 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Are the Potential Problems with Baby Bottles?
Discussion The basic rules for preparing formula and using baby bottles and cups are the same for any food preparation and presentation. Wash hands with clean water. Wash with hot soapy water, rinse and dry all bottles, cups, nipples, rings or other equipment (including breast pumping equipment). Some people recommend boiling these utensils for 5 minutes as well. For glass bottles, a dishwasher with heated water and hot drying cycle can be used. Remember to include any measuring cups, measuring spoons, can opener, etc. which can also touch the formula. Wash, rinse and dry the top of the formula (or other food) container....
Source: PediatricEducation.org - March 25, 2024 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Humans Rely on Gut Bacteria for an Enzyme that Prevents Jaundice
An absence of bilirubin-producing gut microbes may predispose individuals to some diseases, including inflammatory bowel disease. (Source: The Scientist)
Source: The Scientist - February 16, 2024 Category: Science Tags: News News & Opinion Source Type: news

How Pigs Could Help People Who Need Liver Transplants
In this study, eGenesis scientists used CRISPR to make not one, but 69 edits to the pig genome: three to remove the most pig-like proteins that would activate the human system to reject the liver, seven edits to add human genes to the pig liver, and 59 to inactivate pig retroviruses that could cause problems in humans. “Until CRISPR, there was no way to do that many edits easily,” says Curtis. The future of pig livers This single-patient study is just the beginning of what xenotransplants can achieve, says Shaked. The liver has two major duties in the body: regulating critical enzymes and substances such ...
Source: TIME: Health - January 18, 2024 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthscienceclimate Source Type: news

Bilirubin Reductase Enzyme Makes Urine Yellow
Urobilin has long been linked to urine ' s yellow hue, but the enzyme responsible has eluded scientists for over a century (Source: Disabled World)
Source: Disabled World - January 3, 2024 Category: Disability Tags: Medical Research News Source Type: news

How Late Can You Give Routine Newborn Care?
Discussion Routine newborn screening and treatment is focused on assisting the infant’s transition to extrauterine life, screening for health problems that may or may not be easily identifiable, and preventing acute or chronic health problems. Healthy infants begin with healthy pregnancies including risk factor assessment and screening of mothers. Such routine maternal screening and treatment does or may include glucose tolerance tests, ultrasound examinations, screenings for maternal blood type (with appropriate administration of Rho(D) immunoglobulin if appropriate), Hepatitis B, Neisseria gonorrhea, Chlamydia, Cyt...
Source: PediatricEducation.org - November 20, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

How Late Can You Give Routine Newborn Care?
Discussion Routine newborn screening and treatment is focused on assisting the infant’s transition to extrauterine life, screening for health problems that may or may not be easily identifiable, and preventing acute or chronic health problems. Healthy infants begin with healthy pregnancies including risk factor assessment and screening of mothers. Such routine maternal screening and treatment does or may include glucose tolerance tests, ultrasound examinations, screenings for maternal blood type (with appropriate administration of Rho(D) immunoglobulin if appropriate), Hepatitis B, Neisseria gonorrhea, Chlamydia, Cyt...
Source: PediatricEducation.org - November 20, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What's New in the New Jaundice Guidelines? What's New in the New Jaundice Guidelines?
AAP ' s revised guideline, more than 15 years in the making, expands on monitoring and treatment of newborns 35 or more weeks ' gestation to prevent bilirubin encephalopathy and kernicterus.Medscape Pediatrics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 26, 2023 Category: Consumer Health News Tags: Pediatrics Viewpoint Source Type: news

Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage. Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news

Janssen to Highlight Scientific Advances and Commitment to Transform Cancer Care at ASCO and EHA with More than 90 Presentations Showcasing Robust, Differentiated Portfolio and Pipeline in Hematologic Malignancies and Solid Tumors
This study evaluates an investigational combination regimen of IMBRUVICA® (ibrutinib) plus venetoclax (I+V) for newly diagnosed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), (Abstracts #7535 and #P617, respectively).Advancing the Science of Solid Tumors Through Precision MedicineJanssen’s continued innovation in solid tumors focuses on advancing precision medicine options for patients with biomarker-driven disease who have limited targeted treatment options and moving patients into earlier lines of therapy when treatments may be more effective. Lung CancerAn oral presentation will report ...
Source: Johnson and Johnson - May 18, 2023 Category: Pharmaceuticals Tags: Innovation Source Type: news

Update on IMBRUVICA ® (ibrutinib) U.S. Accelerated Approvals for Mantle Cell Lymphoma and Marginal Zone Lymphoma Indications
HORSHAM, Pa., April 6, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson, in collaboration with its alliance partner, Pharmacyclics, an AbbVie Company, announced today the intent to voluntarily withdraw the U.S. indications for IMBRUVICA® (ibrutinib) for the treatment of patients with mantle cell lymphoma (MCL) who have received at least one prior therapy, and for the treatment of patients with marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy. This decision was made in consultation with the U.S. Food and Drug Administration (FDA), c...
Source: Johnson and Johnson - April 6, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Neonatal Bilirubin Meters Need Better Accuracy Neonatal Bilirubin Meters Need Better Accuracy
Point-of-care meters tended to underestimate neonatal bilirubin levels, compared with conventional laboratory-based quantification.MDedge News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - March 13, 2023 Category: OBGYN Tags: Pediatrics News Source Type: news

Late-Breaking Phase 3 A DUE Data Show Investigational Single Tablet Combination Therapy of Macitentan and Tadalafil Significantly Improves Pulmonary Hemodynamics versus Monotherapy in Patients with Pulmonary Arterial Hypertension (PAH)
RARITAN, NJ, March 6, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the Phase 3 A DUE study (NCT03904693), which showed an investigational once-daily, single tablet combination therapy, also known as fixed dose combination, of macitentan 10 mg and tadalafil 40 mg (M/T STCT), significantly improved pulmonary hemodynamics (blood flow through pulmonary blood vessels) versus macitentan and tadalafil monotherapies in pulmonary arterial hypertension (PAH) patients with World Health Organization (WHO) functional class (FC) II or III.[1] The data were presented today as a Late-...
Source: Johnson and Johnson - March 6, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Smartphone-Based Scleral Imaging Can ID Jaundice in Decompensated Cirrhosis
WEDNESDAY, Jan. 11, 2023 -- Smartphone-based assessment of jaundice in patients with decompensated cirrhosis is feasible and accurate, mirroring levels of bilirubin and its correlations with clinical parameters, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 11, 2023 Category: Pharmaceuticals Source Type: news