U.S. FDA Approves New Pediatric Formulation of SIRTURO ® (bedaquiline) as Part of Combination Therapy to Treat Children with Pulmonary Multidrug-Resistant Tuberculosis
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received acceler...
Source: Johnson and Johnson - May 27, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Roche launches new blood gas digital solution designed to improve patient care
Basel, 15 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the CE mark availability of Roche v-TAC, a new digital diagnostic solution that allows clinicians to obtain results for arterial blood gas values from patients with respiratory or metabolic abnormalities via a simpler, less invasive venous puncture through the use of a digital algorithm. Blood gas analysis is typically used in hospital point of care (POC) settings, where quick and accurate results are needed. This includes emergency rooms, intensive care units and operating rooms. The analysis provides clinicians with information about a patient &rsquo...
Source: Roche Media News - May 15, 2020 Category: Pharmaceuticals Source Type: news

Roche launches new blood gas digital solution designed to improve patient care
Basel, 15 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the CE mark availability of Roche v-TAC, a new digital diagnostic solution that allows clinicians to obtain results for arterial blood gas values from patients with respiratory or metabolic abnormalities via a simpler, less invasive venous puncture through the use of a digital algorithm. Blood gas analysis is typically used in hospital point of care (POC) settings, where quick and accurate results are needed. This includes emergency rooms, intensive care units and operating rooms. The analysis provides clinicians with information about a patient &rsquo...
Source: Roche Investor Update - May 15, 2020 Category: Pharmaceuticals Source Type: news

Clinical characteristics and predictors of outcomes of hopsitalised patients with Covid-19 in a London NHS trust: a retrospective cohort study
This report is one of the first studies to describe the characteristics and predictors of outcomes for hospitalised Covid-19 patients in the UK. It finds that older age, male sex and admission hypoxia, thrombocytopenia, renal failure, hypoalbuminaemia and raised bilirubin are associated with increased odds of death. Ethnic minority groups were over-represented in the cohort and, compared to white people, people of black ethnicity may be at increased odds of mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 11, 2020 Category: Consumer Health News Source Type: news

Clinical characteristics and predictors of outcomes of hospitalised patients with Covid-19 in a London NHS trust: a retrospective cohort study, Imperial College London
This report is one of the first studies to describe the characteristics and predictors of outcomes for hospitalised Covid-19 patients in the United Kingdom. It finds that older age, male sex and admission hypoxia, thrombocytopenia, renal failure, hypoalbuminaemia and raised bilirubin are associated with increased odds of death. Minority ethnic groups were over-represented in the cohort and, compared to white people, people of black ethnicity may be at increased odds of mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Landmark 30-year study on Crigler-Najjar syndrome underscores the need for new therapies
(Clinic for Special Children) A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjarsyndrome. The study yields novel insights about the pathophysiology of bilirubin encephalopathy, demonstrates principles of effective phototherapy, and provides a framework to judge emerging molecular therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 16, 2020 Category: International Medicine & Public Health Source Type: news

Two-step Screening Strategy for Biliary Atresia in Newborns Shows Promise Two-step Screening Strategy for Biliary Atresia in Newborns Shows Promise
Newborn screening for biliary atresia using direct or conjugated bilirubin measurements has a high diagnostic yield, detecting all known infants with the rare liver disorder in a large cross-sectional study of infants born at 14 Texas hospitals.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 25, 2020 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Low Bilirubin, Normal Alkaline Phosphatase Tied to Better Outcomes of Biliary Cholangitis Low Bilirubin, Normal Alkaline Phosphatase Tied to Better Outcomes of Biliary Cholangitis
Treatment targets for improved survival in primary biliary cholangitis should include low-normal bilirubin and normal alkaline phosphatase levels, a new study suggests.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 18, 2020 Category: Transplant Surgery Tags: Gastroenterology News Source Type: news

What Do You Do For Breast Milk Jaundice?
Discussion Almost all infants in the first few days of life have some elevation of their bilirubin because of the various physiologic changes they undergo in the transition to extra-uterine life. This is a common problem managed by many different inpatient and outpatient healthcare providers. This hyperbilirubinemia is usually unconjugated and resolves in the first 1-2 weeks of life. However, when it does not resolve, health care providers have 3 general paths to follow when considering a cause: inadequate breast milk intake, an underlying organic cause or breast milk jaundice. Inadequate breastfeeding is not uncommon and...
Source: PediatricEducation.org - February 3, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Checkpoint Inhibitors and the Liver, From Efficacy to AEs Checkpoint Inhibitors and the Liver, From Efficacy to AEs
Immune-related adverse events involving the liver may occur with checkpoint inhibitors. Is routine monitoring of AST, ALT and bilirubin recommended?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 20, 2019 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Bilirubin Test
Title: Bilirubin TestCategory: Diseases and ConditionsCreated: 5/2/2016 12:00:00 AMLast Editorial Review: 7/12/2019 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - July 12, 2019 Category: Nutrition Source Type: news

What Are Common Presentations for Budd-Chairi in Adolescents?
Discussion Budd-Chiari syndrome (BCS) is a rare liver disease caused by hepatic venous outflow obstruction (HVOTO). The obstruction can be anywhere from the small intrahepatic veins up to the inferior vena cava junction with the right atrium. The liver parenchyma itself is not directly affected but becomes compromised because of the increased hepatic sinusoidal pressure over time. The causes include: prothrombic events (35% of cases such as Protein C or Protein S deficiency, Factor V Leiden or antithrombin deficiency), myeloproliferative conditions, oral contraceptive use, and local factors. BCS can occur in any age but i...
Source: PediatricEducation.org - July 8, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Two Variables Accurately Predict Rebound Hyperbilirubinemia Two Variables Accurately Predict Rebound Hyperbilirubinemia
Two variables, gestational age at phototherapy initiation and the difference between starting threshold and post-phototherapy total serum bilirubin (TSB), accurately predict rebound hyperbilirubinemia in infants, researchers report.Reuters Health Information (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - June 14, 2019 Category: Pediatrics Tags: Ob/Gyn & Women ' s Health News Source Type: news

What Does the Liver Do?
Discussion The liver is one of the largest organs in the body, weighing just over 3 pounds in an adult. It is found in the upper right abdomen, under the right dome of the diaphragm. Grossly, it has asymmetric lobes with the right being larger than the left. The lobes are separated by a fibrous connective tissue band that also anchors the liver in the abdominal cavity. The gallbladder is located on the inferior surface of the liver and stores bile, which is then released into the duodenum. Microscopically, the liver cells are arranged in lobules with canals carrying blood vessels and bile ducts. At any moment about 10-13% ...
Source: PediatricEducation.org - April 1, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Doctors Make Mistakes. A New Documentary Explores What Happens When They Do —and How to Fix It
People accept it as fact: that to err is human. Every misstep is an opportunity to learn and improve. But when the mistakes are made by doctors, lives can be compromised, or even lost. Among malpractice claims, about 30% are due to diagnostic errors, according to a report by Coverys, a malpractice services provider. In the U.S. in 2017, surgeons either operated on the wrong patient, the wrong site or performed the wrong procedure 95 times, according to the Joint Commission, which accredits and certifies many healthcare systems in the country. To Err is Human, a new documentary from 3759 Films and Tall Tale Productions that...
Source: TIME: Health - January 24, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Health Care Source Type: news

Misinterpretation of Jaundice Meters Triggers a Recall
Draeger Medical Systems is recalling its Jaundice Meter JM-103 and JM-105 models after some users have misinterpreted display messages that have resulted in serious injuries, according to an FDA notice. The Jaundice Meters are used to measure bilirubin in newborns. Specifically, the JM-103 model displays three blinking dashes (---) and the JM-105 meter displays dash-zero-dash (-0-) when the bilirubin level in the patient is higher than the maximum level of detection. Measurement of high bilirubin indicates a need for immediate medical evaluation. Some users have interpreted the two display messages as indicating a low...
Source: MDDI - June 25, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Regulatory and Compliance Source Type: news

Jaundice Overview Video Jaundice Overview Video
Jaundice is a condition where the skin and eyes take on a yellowish color due to increased levels of bilirubin in the bloodstream. Find out more in this video.Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 25, 2018 Category: Consumer Health News Tags: Med Students Commentary Source Type: news

Medical News Today: This 'natural antioxidant' may protect heart health
Bilirubin, a byproduct of red blood cell breakdown, may speak to cardiovascular health, researchers argue. Further studies should investigate mechanisms. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 21, 2018 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

Natural antioxidant bilirubin may improve cardiovascular health
(Emory Health Sciences) A recent analysis of health data from almost 100,000 veterans, both with and without HIV infection, found that within normal ranges, higher levels of bilirubin in the blood were associated with lower rates of heart failure, heart attack and stroke. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 18, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: How to get rid of yellow eyes
Yellow eyes can result from damage to the liver, pancreas, or gallbladder. These organs help to filter bilirubin, a yellow compound, from the blood. While most cases require medical attention, we look at whether home remedies can be safe and effective. Learn about the causes and treatments of yellow eyes here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 9, 2018 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Bilirubin test
(Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - January 12, 2018 Category: Consumer Health News Source Type: news

Tiny bilirubin-filled capsules could improve survival of transplanted pancreatic cells
(North Carolina State University) By encapsulating bilirubin within tiny nanoparticles, researchers from North Carolina State University and the Ohio State University have improved the survival rates of pancreatic islet cells in vitro in a low-oxygen environment. The work has implications for the treatment of Type 1 diabetes in both canine and human patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 18, 2017 Category: International Medicine & Public Health Source Type: news

Photoacoustic imaging and photothermal cancer therapy using BR nanoparticles
(The Korea Advanced Institute of Science and Technology (KAIST)) Sangyong Jon, a professor in the Department of Biological Sciences at KAIST, and his team developed combined photoacoustic imaging and photothermal therapy for cancer by using Bilirubin (BR) nanoparticles.The team expects this research, which shows high biocompatibility as well as outstanding photoacoustic imaging and photothermal therapy, to be an appropriate system in the field of treatment for cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 25, 2017 Category: Cancer & Oncology Source Type: news

How Common Are Twins?
Discussion Twinning is the conception and development of more than one zygote during one pregnancy. Monozygotic (MZ) twins arise from one zygote that then splits to form two embryos so that the twins are necessarily of the same gender (male-male or female-female). Dizygotic (DZ) twinning arises from the development of two independent zygotes and therefore the genders may be the same or different (male-male, female-female or male-female). Increased risks of spontaneous DZ twinning includes increased maternal age, parity and gravity, family history including familial clustering, maternal obesity and overweight and smoking. ...
Source: PediatricEducation.org - September 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

HealthWatch: Cancer-Detecting App; First-Time Dads Getting Older
BOSTON (CBS) — Pancreatic cancer usually has a poor prognosis, often because it’s caught too late, but could your smartphone one day give you an early warning? Researchers at the University of Washington are developing the BiliScreen app, which will allow people to screen themselves for pancreatic cancer and other diseases by snapping a selfie. The Biliscreen app in use. (WBZ-TV) One of the earliest signs of pancreatic cancer, and other conditions like hepatitis, is jaundice or yellowing of the eyes, which is caused by a build-up of a pigment called bilirubin in the blood. This BiliScreen app uses the smartphon...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 31, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Syndicated Local Fathers HealthWatch Mallika Marshall Pancreatic Cancer Source Type: news

The Scary But Rare Risk Linked To Exclusive Breastfeeding
This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.  -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Healthy Living - The Huffington Post)
Source: Healthy Living - The Huffington Post - March 8, 2017 Category: Consumer Health News Source Type: news

Former NICU Baby Sports Helmet With Totally Fitting Phrase
A viral photo of a preemie wearing a special helmet is spreading a beautiful message of hope and determination. On Monday, a mom named Lori shared a photo of her 8-month-old daughter with the popular Facebook group, Pantsuit Nation. In the photo, the baby wears a cranial helmet with the words “Nevertheless she persisted.” In the caption, Lori dedicated the post to her fellow NICU parents.  “My little girl was born with some health issues that resulted in some pretty intense interventions that ended up saving her,” she wrote. “We were told by the doctors some pretty scary news ... we...
Source: Healthy Living - The Huffington Post - March 1, 2017 Category: Consumer Health News Source Type: news

Severe newborn jaundice could be preventable, mouse study shows
A protein that inhibits the enzyme that breaks down bilirubin in newborns has now been identified by researchers. Methods that block this inhibitor, and thus restore the enzyme ’s activity, could provide a new therapeutic approach for preventing or treating severe newborn jaundice. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 6, 2017 Category: Science Source Type: news

Severe newborn jaundice could be preventable, mouse study shows
(University of California - San Diego) In a mouse study, researchers at University of California San Diego School of Medicine have identified a protein that inhibits the enzyme that breaks down bilirubin in newborns. Methods that block this inhibitor, and thus restore the enzyme's activity, could provide a new therapeutic approach for preventing or treating severe newborn jaundice. The study is published Feb. 6 by the Proceedings of the National Academy of Sciences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2017 Category: Global & Universal Source Type: news

Liver Test Guidelines Updated by ACG Liver Test Guidelines Updated by ACG
Updated ACG liver test guidelines are the first to include specific ranges for normal ALT levels, provide stepwise algorithms for evaluating abnormal ALT, AST, alkaline phosphatase, bilirubin levels.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 12, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Medical News Today: High Bilirubin Levels: Symptoms and Tests
Bilirubin is produced when red blood cells break down. Learn about tests to measure bilirubin and what happens to the body when bilirubin levels are high. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 9, 2017 Category: Consumer Health News Tags: Blood / Hematology Source Type: news

Sepsis Gets an Upgrade
Conclusion “These updated definitions and clinical criteria should clarify long-used descriptors and facilitate earlier recognition and more timely management of patients with sepsis or at risk of developing it. This process, however, remains a work in progress. As is done with software and other coding updates, the task force recommends that the new definition be designated Sepsis-3. With the 1991 and 2001 iterations being recognized as Sepsis-1 and Sepsis-2, respectively, to emphasize the need for future iterations.” Clinical Take Home Points Sepsis = Life-threatening organ dysfunction caused by a dysregulat...
Source: EPMonthly.com - December 31, 2016 Category: Emergency Medicine Authors: Matt McGahen Tags: Uncategorized Source Type: news

Bilirubin Levels and Oxidative Stress in ATV/r vs EFV ART Bilirubin Levels and Oxidative Stress in ATV/r vs EFV ART
A new study explores the changes in bilirubin and oxidative stress biomarkers among HIV-infected patients after ART initiation with atazanavir or an efavirenz-based regimen. How do they compare?HIV Medicine (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - November 23, 2016 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Transcutaneous Bilirubin Testing Is Feasible in Neonates Transcutaneous Bilirubin Testing Is Feasible in Neonates
Transcutaneous bilirubinometry (TcB) is feasible and safe for evaluation of jaundiced neonates, researchers report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2016 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Jaundice could be a sign of THIS serious illness - but what causes the skin to go yellow?
JAUNDICE is a health condition caused by a build up of a substance called bilirubin in the blood and tissue in the body. (Source: Daily Express - Health)
Source: Daily Express - Health - September 2, 2016 Category: Consumer Health News Source Type: news

Bilirubinometers Inaccurate in Black African Neonates Bilirubinometers Inaccurate in Black African Neonates
Transcutaneous bilirubinometers significantly overestimate serum bilirubin and may result in overtreatment in black African neonates, researchers from Nigeria report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 31, 2016 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Obeticholic Acid Effective in Primary Biliary Cholangitis Obeticholic Acid Effective in Primary Biliary Cholangitis
Obeticholic acid reduces alkaline phosphatase and total bilirubin levels in patients with primary biliary cholangitis, according to results from the POISE study.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 24, 2016 Category: Surgery Tags: Gastroenterology News Source Type: news

Bilirubin contributes to immune suppression after islet transplants
(Cell Transplantation Center of Excellence for Aging and Brain Repair) Stress and injury can cause up to a 70 percent loss of transplanted islet cells within 72 hours after transplantation. Bilirubin, an antioxidant, was used successfully as a supplement to suppress the immune response to allograft islet transplantation and also significantly decrease islet cell death after the cells had been isolated and undergone nutrient deprivation and hypoxic (low oxygen) stress. Bilirubin supplementation could improve outcomes after allograft islet cell transplantation to treat type 1 diabetes. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 11, 2016 Category: Biology Source Type: news

Bilirubin (Bilirubin Test)
Title: Bilirubin (Bilirubin Test)Category: Diseases and ConditionsCreated: 5/2/2016 12:00:00 AMLast Editorial Review: 5/3/2016 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - May 3, 2016 Category: Nutrition Source Type: news

Make the Diagnosis: Smear Savvy
(MedPage Today) -- Case Findings: A 45-year old male patient with no significant past medical history presents with recurrent fevers, fatigue, arthralgias, and general malaise that have persisted for the past two months. He denies any weight loss, nausea, vomiting, abdominal pain, or headaches. He is a Boy Scout leader who spent the summer chaperoning at a Boy Scout camp. A physical examination shows fever, scleral icterus, and mild hepatosplenomegaly. Laboratory studies reveal anemia, elevated lactate dehydrogenase, thrombocytopenia, elevated total bilirubin, low haptoglobin, reticulocytosis, elevated liver enzymes, a...
Source: MedPage Today Public Health - April 21, 2016 Category: American Health Source Type: news

Your NEJM Group Today: Opioid Clinical Pearls, Bilirubin Decision Rules, Colorado Family Medicine Opportunities (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:Now@NEJM … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - April 6, 2016 Category: Primary Care Source Type: news

FDA releases February 2016 510(k) clearances
February 2016 510(k) Clearances 510(k) summaries or 510(k) statements for final decisions rendered during the period February 2016. TOTAL 510(k)s THIS PERIOD 224 TOTAL WITH SUMMARIES 213 TOTAL WITH STATEMENTS 11 February 2016 510(k) Clearances 510(K) SUMMARIES OR 510(K) STATEMENTS FOR FINAL DECISIONS RENDERED DURING THE PERIOD February 2016 DEVICE: ANI Monitor MDOLORIS MEDICAL SYSTEMS SAS 510(k) NO: K142969(Traditional) ATTN: MATHILDE COLLET PHONE NO : 011 333 62092081 6, RUE DU PR LAGUESSE SE DECISION MADE: 23-FEB-16 LILLE FR 59037 510(k) SUMMARY AVAILABLE FROM FDA DEVICE: DBSWIN and VistaEasy Imaging Software Durr Dental...
Source: Mass Device - April 5, 2016 Category: Medical Equipment Authors: MassDevice Tags: 510(k) Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news

Test your USMLE Step 2 readiness with this most missed question
If you’re gearing up to take the United States Medical Licensing Examination® (USMLE®) Step 2, this series is for you. Each month, we’re giving you an exclusive scoop on the most missed USMLE Step 2 test prep questions and expert strategies to help you beat them. Check out this month’s most challenging question, and view an expert video explanation of the answer from Kaplan Medical. Think you have what it takes to rise above your peers? Test your USMLE knowledge below. Ready. Set. Go. This month’s question that stumped most students: A 22-year-old African immigrant presents to the hos...
Source: AMA Wire - March 26, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news

Can We Use a Transcutaneous Bilirubin Reading After Phototherapy?
Discussion Unconjugated hyperbilirubinemia in the newborn is a normal occurence. After birth the infant must rely on its own relatively immature liver to detoxify metabolites, the infant’s gastrointestinal tract also is not yet working as well for excretion, the infant is usually slightly fluid deficient before breastfeeding and/or bottle feeding are well established, and there is increased breakdown of red blood cells as the fetus has a higher hemoglobin than an infant and thus an infant is relatively hemoconcentrated. The total bilirubin rises from 1.5 mg/dL to 6.5 mg/dL (+ or -2.5 mg/dL) over the first 3-4 days of...
Source: PediatricEducation.org - March 21, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

International Perspectives: Clinical Kernicterus in Preterm Infants in Japan
In recent years, clinical kernicterus has been diagnosed in preterm infants on the basis of motor (kinetic) disorders such as choreoathetosis and dystonia, impairment in auditory neuropathy-type hearing, and abnormal pallidal signals on head magnetic resonance imaging. In Japan, it is currently estimated that at least 8 to 9 cases of kernicterus (approximately 2 per 1,000 cases) occur annually in preterm infants of less than 30 weeks’ gestation. Therefore, there is an urgent need to revise our jaundice management approach in preterm infants. Two major characteristics of Japanese preterm infants who develop clinical k...
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Morioka, I., Nakamura, H., Iwatani, S., Wong, R. J., Iijima, K. Tags: Pediatric Drug Labeling Update Articles Source Type: news

What Serotypes Cause the Most Group B Streptococcal Disease?
Patient Presentation A 30-minute old, 39 2/7 week gestation female was admitted to the newborn nursery. The past medical history showed she was born to a G2P1 now 2, 28 year old mother who had received appropriate prenatal care. Her pregnancy had been complicated by group B streptococcus (GBS) positive vaginal colonization, but negative for GBS bacturia. She had rupture of membranes 7 hours prior to vaginal delivery and had received 2 doses of ampicillin at 6.5 and 3 hours prior to delivery. She had no intrapartum fever. Apgars were 8 and 9. The family history showed some diabetes and heart disease. The 2.5 year old sibli...
Source: PediatricEducation.org - February 22, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

What Are Current Treatments for Postpartum Depression?
Discussion Postpartum depression affects 10 to 20% of women after delivery, but less than half of these women are detected. Postpartum depression is defined as major depressive episodes with symptom onset during pregnancy or in the first four weeks following delivery. There is recognition that symptoms may begin later after delivery but the mother would not be diagnosed with PPD. PPD is distinct from postpartum blues which occur in 50 to 80% of new mothers. They occur within 1 to 2 days of delivery and resolve within 10-14 days of delivery. Symptoms include anxiety, depression, irritability, tearfulness, poor sleep, and a...
Source: PediatricEducation.org - February 15, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news