Fight Aging! Newsletter, September 30th 2019

In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e., autophagy, SC differentiation) in skeletal muscle that is likely to contribute to sarcopenia and age-related attenuation of adaptive responses to exercise. Altered Calcium Transport in Aging Mitochondria is Maladaptive https://www.fightaging.org/archives/2019/09/altered-calcium-transport-in-aging-mitochondria-is-maladaptive/ Mitochondria are the power plants of the cell, responsible for packaging energy store molecules used to power cellular processes. There are hundreds of them in any given cell, the descendants of ancient symbiotic bacteria. They replicate by fission, like bacteria, and carry a remnant of their original DNA. Mitochondrial function declines with age, a problem that appears to stem from an imbalance in mitochondrial fission that in turn impairs the ability of the cell to clear out worn and malfunctioning mitochondria via...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: December 2019Source: Journal of Adolescence, Volume 77Author(s): Rachel Widome, Aaron T. Berger, Kathleen M. Lenk, Darin J. Erickson, Melissa N. Laska, Conrad Iber, Gudrun Kilian, Kyla WahlstromAbstractIntroductionShort sleep duration is exceedingly common among adolescents and has implications for healthy youth development. We sought to document associations between adolescents’ sleep duration and characteristics of their schedules, behaviors, and wellbeing.MethodsWe used data from the baseline wave (9th grade year) of the START study, a cohort of 2134 students in five Minnesota high schools to ass...
Source: Journal of Adolescence - Category: Child Development Source Type: research
CONCLUSION: The etiology of chronic groin pain post hernia repair is related in part to nerve injury. This is supported by the high frequency of sensory symptoms and numbness in these patients. However other factors including the role of tissue injury and inflammatory postoperative changes need to be considered. KEY WORDS: Chronic postoperative pain, Inguinal hernia repair, Open surgery, Laparoscopic surgery. PMID: 31719216 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Conclusion: Most nonthermal physical treatments are unable to sterilize thoroughly, thereby resulting in suppressed or sublethally injured microbial cells instead of killing them completely. This poses food safety hazards since microorganisms may re-grow at post-processing stage as favorable conditions are available again. Studying the mechanism of these responses on microorganisms may help us to do better in anticipating possible risks during food processing and preventing potential food safety incidents.
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
ConclusionsNatural active food-derived ingredients are marketed as having several benefits on the skin. Their incorporation in food supplements and cosmetics is a reality already marketed. The truth about the benefits of food ingredients in cosmetics is not always properly discussed. The trend of “beauty from within” by oral supplementation is now accompanying the other trend that is “from the kitchen table to the skin”, that refers to the possibility to create cosmetics with the ordinary ingredients one have in the kitchen.Graphical abstract
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): M.A. Augustin, L. Sanguansri, E.M. Fox, L. Cobiac, M.B. ColeAbstractBackgroundFruits and vegetables are an excellent source of nutrients, with numerous health benefits. Most consumers are not meeting the daily recommended intake of fruits and vegetables. Yet, a significant amount of fruits and vegetables that is produced is wasted. There are opportunities to recover the wasted fruits and vegetables for manufacturing value-added products to improve the sustainability of healthy diets and reduce the environmental footp...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): Ryoiti KiyamaAbstractBackgroundGreen tea is produced from the tea plant Camellia sinensis without fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea consti...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
In this study, the effect of pH (3–8), ionic strength (I, 0.01–1 M), protein particle concentration (C, 0.5%–2%), and dispersed phase volume fraction (Φ, 0.25–0.8) on the efficacy of hordein-based colloidal nanoparticles in the stabilization of Pickering structures was investigated. Colloidal particles were synthesized via anti-solvent method. Depending on pH and I, the average size and zeta-potential of hordein particles ranged from 425 to around 4000 nm, and +27.5 to −15.63 mV, respectively. The intense aggregation of particles at pH close to isoelectric point and also at hig...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
The objective of this paper is to synthesise current knowledge on ALK rearrangement and its impact on the management of advanced NSCLC. Several inhibitors of the tyrosine kinase of ALK (crizotinib, ceritinib, alectinib) have been approved as first line therapies in patients with advanced ALK positive NSCLC, which are associated with a better median progression-free survival than conventional chemotherapy. Unfortunately, the emergence of drug resistance leads to tumor progression. In patients with oligoprogressive disease if local ablative therapy can be effected, continuing with the same ALK tyrosine kinase inhibitor is on...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
This study not only determined the primary reason for the atypical IBD epidemic, but also remind us of the urgency for developing new vaccines against novel variant IBDV.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 15 November 2019Source: Veterinary MicrobiologyAuthor(s): Xian-Wei Wang, Mi Wang, Jing Zhan, Qian-Yu Liu, Lin-lin Fang, Chen-yao Zhao, Ping Jiang, Yu-Feng Li, Juan BaiAbstractSince late 2010, highly virulent PEDV G2-genotype strains have emerged globally extracting heavy losses on the pork industries of numerous countries. We investigated the characteristics of a field strain of PEDV (PEDV strain SH) isolated from a piglet with severe diarrhea on a farm in Shanghai China. Whole genome sequencing and analysis revealed that the SH strain belonged to subtype G2a and has a unique 12-aa deleti...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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