Human Gut-Associated Natural Killer Cells in Health and Disease

Human Gut-Associated Natural Killer Cells in Health and Disease Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals and virus infections. The functions of NK cells in the gut are much more complex. Gut NK cells are not precisely organized in lymphoid aggregates but rather scattered in the epithelium or in the stroma, where they come in contact with a multitude of antigens derived from commensal or pathogenic microorganisms in addition to components of microbiota. Furthermore, NK cells in the bowel interact with several cell types, including epithelial cells, fibroblasts, macrophages, dendritic cells, and T lymphocytes, and contribute to the maintenance of immune homeostasis and development of efficient immune responses. NK cells have a key role in the response to intestinal bacterial infections, primarily through production of IFNγ, which can stimulate recruitment of additional NK cells from peripheral b...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Publication date: Available online 15 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lisa M. Bartnikas, Michelle F. Huffaker, William J. Sheehan, Watcharoot Kanchongkittiphon, Carter R. Petty, Robert Leibowitz, Michael C. Young, Wanda Phipatanakul
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan, Aliasger K. SalemAbstractThe primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): T. Arun, Suresh K. Verma, Pritam Kumar Panda, R. Justin Joseyphus, Ealisha Jha, Ali Akbari-Fakhrabadi, Pranesh Sengupta, D.K. Ray, V.S. Benitha, K. Jeyasubramanyan, P.V. SatyamAbstractNanomaterial based paints are in current demand in the area of surface protective coatings due to the significant advances made to improve their antibacterial and anticorrosion characteristics. In this work, we have developed magnetic graphene oxide (MGO) paint with the incorporation of cobalt ferrite (CF) and graphene oxide (GO) along with paint...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
A new study finds that patients with autoimmune disease treated with anti- tumor necrosis factor alpha have an increased risk of developing inflammatory bowel disease.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
This study investigated B. cereus levels in fried rice meals in Milan (Italy) and the effect of a post contamination. Spores of three B. cereus (ATCC 14579, clinical isolate GPe2 and an isolate from fried rice R1) were inoculated in fried rice with ham, scrambled egg and peas, then stored at 10 °C and 15 °C for 5 days; the L2 component of haemolysin BL was quantified in the product. In a second trial, inoculated fried rice was submitted to microwave heating (2 min at 600 W) to investigate a possible decrease in bacterial loads. At 15 °C, spores germinated very quickly, followed by a fast growth espe...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
ConclusionsThe result showed that sampling region, fish status, fish species and sampling month were the main factors influencing infection rate. Regulations or guidelines are urgent in China for the control of Anisakis spp. infection in marine fish.
Source: Food Control - Category: Food Science Source Type: research
Authors: Mian A, Singal AK, Bakhshi S, Sood R, Vikram NK, Ray A Abstract A 21-year old female, recently diagnosed with osteosarcoma of right humerus, presented to the emergency with history of fever, productive cough, chest pain and progressive respiratory distress for six days. Initial investigations suggested pneumonia but she did not respond to parenteral antibiotics. CT pulmonary angiogram revealed bilateral pulmonary artery embolism. Thrombolysis was performed using alteplase, which failed to improve the clinical condition. In view of underlying malignancy, a possibility of tumour-embolism was considered and s...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Fatima J, Gupta N, Karoli R, Chandra A, Jagirdaar S, Arora R, Pandey N Abstract Introduction: Visceral abdominal Fat, not Subcutaneous Abdominal Fat better correlates with insulin resistance. Hence the present study was undertaken to study the association of sonographically assessed visceral and subcutaneous abdominal fat with insulin resistance in patients with pre-diabetes. Material and Methods: It was a hospital based cross sectional study done in prediabetes subjects. All the subjects were called fasting overnight and were given a structured questionnaire designed by investigator. Fasting and postp...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: S A, Gurtoo A, M S, Ap MK Abstract Introduction: Health literacy is the degree to which an individual can obtain, process, understand and communicate about health related information to make informed health decisions. Our aim was to study the influence of Diabetic health literacy in affecting the glycemic control in Diabetic patients. Methodology: This is a Cross sectional Analytical study in 200 diabetic patients. Diabetic Knowledge Test developed by Michigan Diabetic Research and Training Center was modified after appropriate permission and was used to measure health literacy. HbA1C was used as a mea...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: We concluded that that patients who develop hypoglycaemia may have an equally bad prognosis or even worse than those who develop hyperglycaemia during the period of critical illness. CGM devices record tissue glucose levels continuously, and may be useful as a 'tissue hypoglycaemia' alert. PMID: 31299838 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
More News: Actemra | Adenocarcinoma | Allergy | Allergy & Immunology | Anatomy | Asthma | Autoimmune Disease | Brain | Cancer | Cancer & Oncology | Carcinoma | Chemotherapy | Child Development | Children | Cholesterol | Clinical Trials | Colon Cancer | Colorectal Cancer | Crohn's Disease | Dermatitis | Dermatology | Diabetes | Diabetes Type 1 | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epithelial Cancer | Food Allergy | Food and Drug Administration (FDA) | Funding | Gastric (Stomach) Cancer | Gastroenteritis | Gastroenterology | Genetics | Hepatocellular Carcinoma | Hormones | Hospitals | Immunotherapy | Infectious Diseases | Inflammatory Bowel Disease | Italy Health | Listeria | Liver | Liver Cancer | Liver Transplant | Men | Metabolic Syndrome | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Neurosurgery | Nutrition | Obesity | Pancreas | Pancreatic Cancer | Parasitic Diseases | Parasitology | Physiology | Probiotics | Psoriasis | Respiratory Medicine | Salmonella | Stelara | Stem Cell Therapy | Stem Cells | Study | Toxicology | Translocation | Transplants | Tuberculosis | Ulcerative Colitis | Undifferentiated Carcinoma | Urology & Nephrology | USA Health | Websites | Yersinia