4,000-Year-Old DNA Identifies Britain's Oldest Known Case of Plague
WEDNESDAY, May 31, 2023 -- Researchers have identified the oldest cases of plague in Britain to date, with DNA that is 4,000 years old. The team from the Francis Crick Institute in London has found three ancient British cases of Yersinia pestis --... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 31, 2023 Category: General Medicine Source Type: news

Oldest evidence of plague in Britain found in 4,000-year-old human remains
Traces of Yersinia pestis bacteria were found in teeth of people buried at bronze age sites in Cumbria and SomersetThe oldest evidence for the plague in Britain has been discovered in 4,000-year-old human remains unearthed at bronze age burial sites in Cumbria and Somerset.Traces ofYersinia pestis bacteria were found in the teeth of individuals at the Levens Park ring cairn monument near Kendal, and Charterhouse Warren in the Mendips, a site where at least 40 men, women and children were buried, dismembered, in a natural shaft.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - May 30, 2023 Category: Science Authors: Ian Sample Science editor Tags: Archaeology Science Infectious diseases UK news Cumbria Microbiology Epidemics Source Type: news

Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
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Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news

Incidence of Infections Caused by Salmonella Reduced in 2021
THURSDAY, Oct. 6, 2022 -- During 2021, there was a decrease in the incidence of infections caused by Salmonella and an increase in incidence of infections caused by Cyclospora, Yersinia, and Vibrio, according to research published in the Oct. 7... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 6, 2022 Category: Pharmaceuticals Source Type: news

Black Death Likely Originated in Central Asia
Genetic testing of people who died in Kyrgyzstan eight years before plague reached Europe reveals an ancient strain of the bacterium Yersinia pestis. (Source: The Scientist)
Source: The Scientist - June 15, 2022 Category: Science Tags: News & Opinion Source Type: news

800-year-old graves pinpoint where the Black Death began
The Syriac engraving on the medieval tombstone was tantalizing: “This is the tomb of the believer Sanmaq. [He] died of pestilence.” Sanmaq, who was buried in 1338 near Lake Issyk Kul in what is now northern Kyrgyzstan, was one of many victims of the unnamed plague. By scrutinizing field notes and more photos from the Russian team that had excavated the graves in the 1880s, historian Philip Slavin found that at least 118 people from Sanmaq’s Central Asian trading community died in the epidemic. Slavin was on the trail of the origin of the Black Death, which devastated Europe a decade after the Kyrgyzstan burials...
Source: ScienceNOW - June 15, 2022 Category: Science Source Type: news

' Black Plague' Was Killing People at Least 5,000 Years Ago
WEDNESDAY, June 30, 2021 -- The Black Death was stalking people thousands of years earlier than previously known, new evidence reveals. The oldest strain of Yersinia pestis -- the bacteria behind the bubonic plague that may have killed as much as... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 30, 2021 Category: General Medicine Source Type: news

This 5,000-year-old man had the earliest known strain of plague
(Cell Press) The oldest strain of Yersinia pestis -- the bacteria behind the plague that caused the Black Death, which may have killed as much as half of Europe's population in the 1300s -- has been found in the remains of a 5,000-year-old hunter-gatherer. A genetic analysis publishing June 29 in the journal Cell Reports reveals that this ancient strain was likely less contagious and not as deadly as its medieval version. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 29, 2021 Category: Infectious Diseases Source Type: news

First evidence that medieval plague victims were buried individually with 'considerable care'
(University of Cambridge) DNA analysis has revealed the presence of 'Yersinia Pestis' - the pathogen that causes plague - in skeletal remains from individual burials in medieval Cambridgeshire, confirming for the first time that not all plague victims were buried in mass graves. Compassion and care were shown to victims even during traumatic times during past pandemics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2021 Category: International Medicine & Public Health Source Type: news

Type III secretion system effectors form robust and flexible intracellular virulence networks
Infections with many Gram-negative pathogens, including Escherichia coli, Salmonella, Shigella, and Yersinia, rely on type III secretion system (T3SS) effectors. We hypothesized that while hijacking processes within mammalian cells, the effectors operate as a robust network that can tolerate substantial contractions. This was tested in vivo using the mouse pathogen Citrobacter rodentium (encoding 31 effectors). Sequential gene deletions showed that effector essentiality for infection was context dependent and that the network could tolerate 60% contraction while maintaining pathogenicity. Despite inducing very different co...
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Ruano-Gallego, D., Sanchez-Garrido, J., Kozik, Z., Nunez-Berrueco, E., Cepeda-Molero, M., Mullineaux-Sanders, C., Naemi-Baghshomali Clark, J., Slater, S. L., Wagner, N., Glegola-Madejska, I., Roumeliotis, T. I., Pupko, T., Fernandez, L. A., Rodriguez-Pato Tags: Engineering, Microbiology, Online Only r-articles Source Type: news

What Causes Joint Pain?
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - October 26, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

We Need to Rethink Our Food System to Prevent the Next Pandemic
Once a dangerous new pathogen is out, as we are seeing, it can be difficult if not impossible to prevent it going global. One as contagious as SARS-CoV-2 has the potential to infect the whole of humanity. Eighty per cent of cases may be benign, but with such a large pool of susceptible hosts, the numbers who experience severe illness and die can still be shockingly high. So the only sensible answer to the question, how do we stop this from happening again, is: by doing all we can to prevent such pathogens infecting humans in the first place. And that means taking a long, hard look at our relationship with the natural world...
Source: TIME: Health - April 13, 2020 Category: Consumer Health News Authors: Laura Spinney Tags: Uncategorized COVID-19 Source Type: news

A forensic evaluation of plague - a re-emerging infectious disease with biowarfare potential - Byard RW.
Plague is an acute infectious disease caused by the gram-negative cocco-bacillus Yersinia pestis. It has been responsible for 200 million deaths throughout history with three major pandemics. There are three forms: bubonic, septicaemic and pneumonic, e... (Source: SafetyLit)
Source: SafetyLit - March 23, 2020 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

Plagues and People – The Coronavirus in a Historical Perspective
By Jan LundiusSTOCKHOLM / ROME, Mar 19 2020 (IPS) The human factor is intimately involved in the origin, spread, and mitigation of the Coronavirus and we cannot afford to ignore that our future existence depends on compassion and cooperation. Response matters! Some quarantined Italians might recall Giovanni Boccaccio´s The Decameron from 1353 in which people escaping the plague are secluded in a villa where they tell stories to each other. Boccaccio introduced his collection of short stories with an eyewitness account of horrifying human suffering in Florence, which in 1348 was struck by a ”pestilence” that every day...
Source: IPS Inter Press Service - Health - March 19, 2020 Category: International Medicine & Public Health Authors: Jan Lundius Tags: Global Headlines Health Humanitarian Emergencies TerraViva United Nations Women's Health Source Type: news

How diarrhea pathogens switch into attack mode at body temperature
(Ruhr-University Bochum) Many bacterial pathogens excrete toxins as soon as they have entered the host in order to suppress its immune response. Researchers at Ruhr-Universit ä t Bochum (RUB) have analysed what happens on the molecular level when the diarrhea pathogen Yersinia pseudotuberculosis switches into attack mode. To this end, they examined so-called RNA thermometers, which signal to the bacteria whether they are in the host. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 20, 2020 Category: Infectious Diseases Source Type: news