In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride

Conclusions: Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404 Received: 22 November 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 22 August 2017 Address correspondence to G. Cortopassi, 1089 Veterinary Medicine Drive, Davis, CA 95616 USA. Phone: (530) 304-6810. Email: gcortopassi@ucdavis.edu. The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Introduction Antimicrobial quaternary ammonium salts (QUATS) compounds, such as cetylpyridinium chloride (CPC) and benzalkonium chloride (BAK), have been used in personal care products, such as soaps and body washes, until the recent U.S. Food and D...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

Related Links:

Publication date: February 2020Source: Alter, Volume 14, Issue 1Author(s):
Source: ALTER - European Journal of Disability Research - Category: Disability Source Type: research
In this study we tried to explore Diazepam as a repurposed drug and tested it in Neuroblastoma (Neuro 2a) cells. Diazepam loaded Poly Lactic Acid Nanoparticles were developed (D-PLA-NPs) using nanoprecipitation method. Entrapment efficiency was found to be ± 99.7% and drug loading was ± 12.88%. The particle size developed was 188.8 nm and zeta potential was −25.6 millivolt. Dissolution profiles were studied in PBS (pH 7.4) or simulated media, almost 50% release was observed within 6 h. In vitro, cytotoxicity was analyzed using MTT assay where dose-dependent cytotoxicity was observed for developed D-PLA-NPs.
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
In this study, we present the effect of doping of sodium (Na) in nickel oxide nanocrystals synthesized using the co-precipitation method. The samples are characterized using X-ray diffraction (XRD) and analyzed further with the help of Raman and Fourier transform infrared (FTIR) spectroscopic data. The XRD peaks, calculated crystallite size, dislocation density, strain and FTIR and Raman spectroscopic data is compared for the samples with the different doping concentrations. The crystal growth is explained on the basis of the recorded data. The experimental data is in good agreement mutually and, with the earlier reports.
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
This article reviews the application of an alternative method, functional near-infrared spectroscopy (fNIRS), to the study of cerebral oxygenation changes in MCI and dementia. We synthesized 36 fNIRS studies that examined hemodynamic changes during both the resting state and the execution of tasks of word retrieval, memory, motor control, and visuospatial perception in MCI and dementia. This qualitative review reveals that (amnestic) MCI and AD patients have disrupted frontal and long-range connectivity in the resting state compared to individuals with normal cognition (NC). These patients also exhibit reduced frontal oxyg...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Conclusions: Detection of the second messengers IP1, cAMP, and calcium, can be used to reliably analyze GPCR activation in intact islets. PMID: 32082084 [PubMed]
Source: Biological Procedures Online - Category: Molecular Biology Authors: Tags: Biol Proced Online Source Type: research
Publication date: Available online 22 February 2020Source: NeuroImageAuthor(s): Ima Trempler, Paul-Christian Bürkner, Nadiya El-Sourani, Ellen Binder, Paul Reker, Gereon R. Fink, Ricarda I. SchubotzAbstractThe brain's sensitivity to and accentuation of unpredicted over predicted sensory signals plays a fundamental role in learning. According to recent theoretical models of the predictive coding framework, dopamine is responsible for balancing the interplay between bottom-up input and top-down predictions by controlling the precision of surprise signals that guide learning.Using functional MRI, we investigated whether ...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 22 February 2020Source: Clinica Chimica ActaAuthor(s): Samsul Arefin, Sarah Buchanan, Sam Hobson, Julia Steinmetz, Shno Alsalhi, Paul G Shiels, Karolina Kublickiene, Peter StenvinkelAbstractUnder normal physiological conditions, free radical generation and antioxidant defences are balanced, and reactive oxygen species (ROS) usually act as secondary messengers in a plethora of biological processes. However, when this balance is impaired, oxidative stress develops due to imbalanced redox homeostasis resulting in cellular damage. Oxidative stress is now recognized as a trigger of cellular se...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: Available online 22 February 2020Source: Obesity Research &Clinical PracticeAuthor(s): Xia Meng, Duo Huang, Hua Ao, Xinyu Wang, Xiao GaoAbstractIntroductionGrowing researches have shown that obese/overweight and healthy weight individuals exhibit different neural responses to food-related stimuli. Accordingly, researchers proposed several theories to explain these differences. Hereon, meta-analyses were conducted using activation likelihood estimation (ALE) to verify these theories and specify the reason of overeating from two aspects.Materials and MethodsPubmed, Web of Science and Neurosynth were sea...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
Conclusion: The results suggest that traditional herbal combination may safely improve glycemic control in type II diabetic patients with no significant adverse effect. PMID: 32081056 [PubMed - as supplied by publisher]
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
Authors: Girish P, Jayanthi M, Gitanjali B, Manikandan S, Rajan S Abstract BACKGROUND: The medical and social impact of being overweight, as well as the difficulty in making long-term changes in diet, physical activity, and pitfalls associated with allopathic management, lure obese individuals to over-the-counter weight-loss herbal products (WHPs). However, the safety of herbals is questionable, as reports from all over the world suggest adulteration with synthetic weight loss agents. OBJECTIVE: The present study was carried out to develop a rapid and sensitive method to screen potential weight loss adulterants...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
More News: Academia | Alzheimer's | Antimicrobial Resistance | Autism | Biochemistry | Biology | Bone Cancers | Brain | Brain Cancers | Breast Carcinoma | Breast Needle Aspiration | Cancer | Cancer & Oncology | Cancer of the Uterus | Carcinoma | Cardiology | Chemistry | Chemotherapy | Chia | Child Development | Children | Chloride | Databases & Libraries | Dermatology | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epithelial Cancer | Estradiol | Ganglions | Genetics | Health Management | Heart | Hepatocellular Carcinoma | Hormones | Insulin | Legislation | Liver | Liver Cancer | Luxembourg Health | Men | Mitochondria | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Obesity | Opthalmology | Oral Cancer | Osteosarcoma | Ovarian Cancer | Ovaries | Parkinson's Disease | Penicillin | Perinatology & Neonatology | Poisoning | Reproduction Medicine | Respiratory Medicine | Science | Sodium | Statistics | Study | Toxicology | Urology & Nephrology | Veterinary Research | Vitamin A