In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride

Conclusions:
Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404

Received: 22 November 2016
Revised: 04 May 2017
Accepted: 09 May 2017
Published: 22 August 2017
Address correspondence to G. Cortopassi, 1089 Veterinary Medicine Drive, Davis, CA 95616 USA. Phone: [phone]. Email: [e-mail].
The authors declare they have no actual or potential competing financial interests.
Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [e-mail]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

Introduction
Antimicrobial quaternary ammonium salts (QUATS) compounds, such as cetylpyridinium chloride (CPC) and benzalkonium chloride (BAK), have been used in personal care products, such as soaps and body washes, until the recent U.S. Food and Drug Administration...

Source: EHP Research - August 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research