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From Ambient to Personal Temperature: Capturing the Experience of Heat Exposure
PDF Version (831 KB) About This Article Published: 22 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Heat exposure can have a wide range of adverse effects on the h...
Source: EHP Research - September 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Estimated Deficiencies Resulting from Reduced Protein Content of Staple Foods: Taking the Cream out of the Crop?
PDF Version (619 KB) About This Article Published: 22 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Projected changes in climate are expected to play a complicated...
Source: EHP Research - September 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Portable Functional Neuroimaging as an Environmental Epidemiology Tool: A How-To Guide for the Use of fNIRS in Field Studies
Conclusion The overarching goal of this paper is to demonstrate the feasibility of employing functional neuroimaging in epidemiological studies regardless of the location or the conditions in which the study is taking place. Critically, this is now possible using readily available, portable fNIRS neuroimaging devices to assess neurobehavioral functioning across multiple domains. Most importantly, in our study, the addition of the fNIRS assessment did not interfere with the goals of the ongoing epidemiological study and was seamlessly integrated into daily operations. This paper provides a set of general guidelines that epi...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells
Conclusions: We propose that the inhibition of chromatin assembly represents a novel mechanism of cell transformation induced by the environmental and occupational chemical carcinogen FA. https://doi.org/10.1289/EHP1275 Received: 25 October 2016 Revised: 19 May 2017 Accepted: 23 May 2017 Published: 21 September 2017 Address correspondence to C. Jin, Dept. of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd., Tuxedo Park, NY 10987 USA. Telephone: (845) 731-3602. Email: Chunyuan.jin@nyumc.org *Current affiliation: Medical School of Nanjing University, Nanjing, China. †Current affil...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Conclusions: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330 Received: 07 November 2016 Revised: 13 July 2017 Accepted: 21 July 2017 Published: 20 September 2017 Address correspondence to C. B. Manzano-Salgado, ISGlobal–Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguader, 8808003 Barcelona, Catalonia, Spain. Phone: +34 932 147 314. Email: cyntia.manzano@isglobal.org Supplemental Material is available online (https...
Source: EHP Research - September 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Integrating Health into Local Climate Response: Lessons from the U.S. CDC Climate-Ready States and Cities Initiative
Conclusion Through relatively small amounts of grant support over the last 6 y, CRSCI has helped local public health agencies in sixteen states and two cities—whose combined population reaches half of the U.S. total—identify critical climate impacts and vulnerable populations. In the process, the program has helped to integrate health more fully into local climate change efforts. As a result of CRSCI support, these local public health agencies—the backbone of public health climate response capacity—have tools to enhance real-life adaptive capacity and increase the effectiveness of existing intervent...
Source: EHP Research - September 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6 –12 Years of Age in Mexico
Conclusions: In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6–12 y. https://doi.org/10.1289/EHP655 Received: 14 June 2016 Revised: 08 May 2017 Accepted: 09 May 2017 Published: 19 September 2017 Please send correspondence to M. Bashash, Dalla Lana School of Public Health, 6th floor, 155 College St., Toronto, Ontario M5R3M7 Canada. Telephone: +1-416-978-6512. Email: m.bashash@utoronto.ca Supplement...
Source: EHP Research - September 19, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

In Memoriam: Herbert L. Needleman
PDF Version (254 KB) About This Article About This Article Supplemental Material Received: 03 August 2017 Accepted: 03 August 2017 Published: 19 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility need...
Source: EHP Research - September 19, 2017 Category: Environmental Health Authors: Web Admin Tags: In Memoriam Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. E...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Lifelong Residential Exposure to Green Space and Attention: A Population-based Prospective Study
Conclusion: Exposure to residential surrounding greenness was associated with better scores on tests of attention at 4–5 y and 7 y of age in our longitudinal cohort. https://doi.org/10.1289/EHP694 Received: 23 June 2016 Revised: 20 July 2017 Accepted: 21 July 2017 Published: 18 September 2017 Address correspondence to P. Dadvand, ISGlobal, Doctor Aiguader, 88, 08003, Barcelona, Spain. Telephone: 34 93 214 7317. Email: payam.dadvand@isglobal.org Supplemental Material is available online (https://doi.org/10.1289/EHP694). The authors declare they have no actual or potential competing financial interests. Note to r...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit ™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY
Conclusions: Potential exposure to Corexit™ EC9527A or EC9500A was associated with a range of health symptoms at the time of the OSRC, as well as at the time of study enrollment, 1–3 y after the spill. https://doi.org/10.1289/EHP1677 Received: 25 January 2017 Revised: 20 June 2017 Accepted: 26 June 2017 Published: 15 September 2017 Address correspondence to D.P. Sandler, Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, 111 TW Alexander Dr., Research Triangle Park, NC 27709-2233 USA. Telephone: 919-541-4668. Email: Dale.Sandler@nih.gov Supplemental Material ...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years
Conclusions: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose–response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314 Received: 02 November 2016 Revised: 23 May 2017 Accepted: 19 June 2017 Published: 15 September 2017 Address correspondence to C. Philippat, Institut for Advanced Biosciences, Site Santé – Allée des Alpes, 38700 La Tronche, France. Phone: +33 4...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Adipogenic Effects and Gene Expression Profiling of Firemaster ® 550 Components in Human Primary Preadipocytes
Conclusions: We found that FM550, and two of its components, induced adipogenesis in human primary preadipocytes. Further, using global gene expression analysis we showed that both TPP and IPTP likely exert their effects through PPARG to induce adipogenesis. In addition, IPTP perturbed signaling pathways that were not affected by TPP. https://doi.org/10.1289/EHP1318 Received: 02 November 2016 Revised: 18 May 2017 Accepted: 23 May 2017 Published: 14 September 2017 Address correspondence to E. Atlas, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, K1A 0K9, Canada...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Changes in Transportation-Related Air Pollution Exposures by Race-Ethnicity and Socioeconomic Status: Outdoor Nitrogen Dioxide in the United States in 2000 and 2010
Conclusions: Findings suggest that absolute NO2 exposure disparities by race-ethnicity decreased from 2000 to 2010, but relative NO2 exposure disparities persisted, with higher NO2 concentrations for nonwhites than whites in 2010. https://doi.org/10.1289/EHP959 Received: 15 August 2016 Revised: 07 June 2017 Accepted: 09 June 2017 Published: 14 September 2017 Please address correspondence to J.D. Marshall, Dept. of Civil, Environmental, and Geo-Engineering, University of Washington, 201 More Hall, Seattle, WA 98195 USA. Telephone: (206) 685-2591. Email: jdmarsh@uw.edu Supplemental Material is available online (https:/...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Randomized Trial of Interventions to Improve Childhood Asthma in Homes with Wood-burning Stoves
Conclusions: Among children with asthma and chronic exposure to woodsmoke, an air-filter intervention that improved indoor air quality did not affect quality-of-life measures. Intent-to-treat analysis did show an improvement in the secondary measure of dPFV. Trial registration: ClincialTrials.gov NCT00807183. https://doi.org/10.1289/EHP849 Received: 21 July 2016 Revised: 13 June 2017 Accepted: 16 June 2017 Published: 13 September 2017 Address correspondence to C.W. Noonan, School of Public and Community Health Sciences, 32 Campus Dr., University of Montana, Missoula, MT 59812 USA. Telephone: (406) 243-4957; Fax: (406...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Children ’s Lead Exposure: A Multimedia Modeling Analysis to Guide Public Health Decision-Making
Conclusions: This methodology advances scientific understanding of the relationship between lead concentrations in drinking water and BLLs in children. It can guide national health-based benchmarks for lead and related community public health decisions. https://doi.org/10.1289/EHP1605 Received: 12 January 2017 Revised: 09 May 2017 Accepted: 18 May 2017 Published: 12 September 2017 Address correspondence to V. Zartarian, 5 Post Office Square, Suite 100, MC ORA 01-3, Boston, MA 02109-3912 USA. Telephone: (617) 918-1541. Email: zartarian.valerie@epa.gov Supplemental Material is available online (https://doi.org/10.1289/...
Source: EHP Research - September 12, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Scientific Challenges in the Risk Assessment of Food Contact Materials
Conclusion: We think that exposures to hazardous substances migrating from FCAs require more attention. We recommend a) limiting the number and types of chemicals authorized for manufacture and b) developing novel approaches for assessing the safety of chemicals in FCAs, including unidentified chemicals that form during or after production. https://doi.org/10.1289/EHP644 Received: 10 June 2016 Revised: 08 June 2017 Accepted: 09 June 2017 Published: 11 September 2017 Address correspondence to J. Muncke, Food Packaging Forum, Staffelstrasse 8, 8045 Zurich, Switzerland. Telephone: 41-44-5155255. Email: jane.muncke@fp-fo...
Source: EHP Research - September 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Early-Life Phthalate Exposure and Adiposity at 8 Years of Age
Conclusion: In this cohort, we did not find evidence of an obesogenic effect of prenatal phthalate exposure. Positive associations between postnatal MEP and ∑DEHP concentrations depended on the timing of exposure. https://doi.org/10.1289/EHP1022 Received: 29 August 2016 Revised: 17 February 2017 Accepted: 28 February 2017 Published: 11 September 2017 Address Correspondence to J.R. Shoaff, Brown University School of Public Health, Box G-S121-2, Providence, RI 02912 USA. Email: jessica_shoaff@brown.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1022). The authors declare they have no actu...
Source: EHP Research - September 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder
This study focuses on exposures during the index period, defined as the 3 mo before conception, and during pregnancy. The date of conception was calculated by subtracting gestational age (reported by mothers) from the child’s date of birth. Maternal FA intake. Maternal intake of FA and other nutrients was determined using data collected through telephone interviews on intake of multivitamins, prenatal vitamins, nutrient-specific vitamins, cereals, and other fortified foods or supplements (i.e., breakfast shakes and protein bars), for each month of the index period as described previously (Schmidt et al. 2012, 2014)....
Source: EHP Research - September 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

In Utero Exposure to Select Phenols and Phthalates and Respiratory Health in Five-Year-Old Boys: A Prospective Study
Conclusion: Ethyl-paraben, bisphenol A, 2,5-dichlorophenol, and DIDP tended to be associated with altered respiratory health, with ethyl-paraben and bisphenol A exhibiting some consistency across respiratory outcomes. The trends between bisphenol A pregnancy level and increased asthma and bronchiolitis/bronchitis rates in childhood were consistent with a previous cohort study. https://doi.org/10.1289/EHP1015 Received: 25 August 2016 Revised: 12 January 2017 Accepted: 26 January 2017 Published: 08 September 2017 Address correspondence to C. Vernet, Institute for Advanced Biosciences (IAB), Centre de Recherche INSERM&n...
Source: EHP Research - September 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population
Author Affiliations open 1Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA 2Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA 3Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA 4Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA PDF Version (188 KB) Abstract About This Article Supplemental Material Background: Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin ...
Source: EHP Research - September 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Exposure to Road, Railway, and Aircraft Noise and Arterial Stiffness in the SAPALDIA Study: Annual Average Noise Levels and Temporal Noise Characteristics
Conclusions: Long-term exposure to railway noise, particularly in an intermittent nighttime noise environment, and to nighttime noise events, mainly related to road noise, may affect arterial stiffness, a major determinant of cardiovascular disease. Ascertaining noise exposure characteristics beyond average noise levels may be relevant to better understand noise-related health effects. https://doi.org/10.1289/EHP1136 Received: 23 September 2016 Revised: 20 March 2017 Accepted: 31 March 2017 Published: 07 September 2017 Address correspondence to M. Foraster, Swiss Tropical and Public Health Institute, Dept. of Epidemi...
Source: EHP Research - September 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Estimated Changes in Life Expectancy and Adult Mortality Resulting from Declining PM2.5 Exposures in the Contiguous United States: 1980 –2010
Conclusions: Our estimates suggest that declines in PM2.5 exposures between 1980 and 2010 have benefitted public health. https://doi.org/10.1289/EHP507 Received: 13 May 2016 Revised: 19 June 2017 Accepted: 20 June 2017 Published: 06 September 2017 Address correspondence to N. Fann, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Mail drop C539-07; RTP, NC 27711 USA. Phone: (919) 541-0209. Email: Fann.neal@epa.gov Supplemental Material is available online (https://doi.org/10.1289/EHP507). The authors declare they have no actual or potential competing financial interests. The views in this manuscript are ...
Source: EHP Research - September 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Insecticide Use and Breast Cancer Risk among Farmers ’ Wives in the Agricultural Health Study
Conclusion: Use of several organophosphate insecticides was associated with elevated breast cancer risk. However, associations for the women’s and husbands’ use of these insecticides showed limited concordance. Ongoing cohort follow-up may help clarify the relationship, if any, between individual insecticide exposures and breast cancer risk. https://doi.org/10.1289/EHP1295 Received: 28 October 2016 Revised: 25 April 2017 Accepted: 08 May 2017 Published: 06 September 2017 Address correspondence to L. Engel, Dept. of Epidemiology, University of North Carolina, CB #7435, Chapel Hill, NC 27599-7435 USA. Telep...
Source: EHP Research - September 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Application of Adverse Outcome Pathways to U.S. EPA ’s Endocrine Disruptor Screening Program
Conclusions: A variety of biological systems affect apical end points used in regulatory risk assessments, and without mechanistic data, an endocrine mode of action cannot be determined. Because the EDSP was designed to consider mode of action, toxicity pathway and AOP concepts are a natural fit. Pathway frameworks have diverse applications to endocrine screening and testing. An estrogen pathway example is presented, and similar approaches are being used to evaluate alternative methods and develop predictive models for androgen and thyroid pathways. https://doi.org/10.1289/EHP1304 Received: 31 October 2016 Revised: 13 ...
Source: EHP Research - September 1, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice
Conclusions: These data demonstrate the critical role of neural AR in courtship vocalizations and raises the possibility that the vulnerability of this signaling pathway to exposure to endocrine disrupters may be detrimental for courtship communication and mating in several species. https://doi.org/10.1289/EHP1443 Received: 01 December 2016 Revised: 08 June 2017 Accepted: 09 June 2017 Published: 01 September 2017 Address correspondence to S. Mhaouty-Kodja, INSERM U1130, CNRS UMR 8246, Université P. & M. Curie, 7 quai St Bernard, Bât A 3ème étage 75005, Paris, France. Phone: +331 44 27 9...
Source: EHP Research - September 1, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis
Conclusions: Our results provide suggestive evidence of the potential for environmental exposure to phthalates and/or BPA to disrupt circulating vitamin D levels in pregnancy. https://doi.org/10.1289/EHP1178 Received: 03 October 2016 Revised: 10 May 2017 Accepted: 12 May 2017 Published: 31 August 2017 Address correspondence to J.D. Meeker, Dept. of Environmental Health Sciences, University of Michigan School of Public Health, 1835 SPH I, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029 USA. Telephone: (734) 764-7184. Email: meekerj@umich.edu Supplemental Material is available online (https://doi.org/10.1289/EH...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Association of Long-Term Exposure to Transportation Noise and Traffic-Related Air Pollution with the Incidence of Diabetes: A Prospective Cohort Study
We examined the influence of transportation noise exposure over a 5-y period (1994–1998) on incident diabetes cases in a population-based prospective cohort study (n=380,738) of metropolitan Vancouver (BC) residents who were 45–85 y old, with 4-y of follow-up (1999–2002). Annual average transportation noise (Lden), air pollution [black carbon, particulate matter with aerodynamic diameter 10% of the population was of South Asian ethnicity, and nearly one-half of the sample lived in neighborhoods where>10% of the population was of Chinese ethnicity. All covariates were significantly associated with all o...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology
Conclusions: Our findings indicate that the transformation of the field of toxicology is partly implemented, but significant barriers to acceptance and adoption remain. https://doi.org/10.1289/EHP1435 Received: 29 November 2016 Revised: 15 June 2017 Accepted: 17 June 2017 Published: 30 August 2017 Address correspondence to P. Allard, Institute for Society and Genetics, 3360 Life Science Building, University of California, Los Angeles, Los Angeles, CA 90095 USA. Telephone: (310) 825-5257. Email: pallard@ucla.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1435). The authors declare they have ...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case –Control Study in California
Conclusions: Contrary to expectation, higher PBDE concentrations were associated with decreased odds of ASD and ID, though not in girls. These findings require confirmation but suggest potential sexual dimorphism in associations with prenatal exposure to BFRs. https://doi.org/10.1289/EHP1079 Received: 09 September 2016 Revised: 18 May 2017 Accepted: 25 May 2017 Published: 30 August 2017 Address correspondence to K. Lyall, 3200 Market St., Suite 560, A.J. Drexel Autism Institute, Philadelphia, PA 19104 USA. Telephone: (215) 571-3215. Email: kld98@drexel.edu Supplemental Material is available online (https://doi.org/10...
Source: EHP Research - August 30, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Exposure to Mercury: Associations with Global DNA Methylation and Hydroxymethylation in Cord Blood and in Childhood
Conclusions: Prenatal mercury exposure was associated with lower %-5hmC genomic content and a corresponding increase in the ratio of %-5mC to %-5hmC in cord blood. This association was persistent in early but not midchildhood blood. Our results demonstrate the potential malleability of epigenetic modifications associated with mercury exposure in utero. https://doi.org/10.1289/EHP1467 Received: 06 December 2016 Revised: 04 May 2017 Accepted: 19 May 2017 Published: 29 August 2017 Address correspondence to A. Cardenas, Dept. of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Pa...
Source: EHP Research - August 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Value of Traditional Ecological Knowledge for the Environmental Health Sciences and Biomedical Research
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - August 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Updated Global Estimates of Respiratory Mortality in Adults ≥ 30 Years of Age Attributable to Long-Term Ozone Exposure
Conclusions: These findings suggest that the potential magnitude of health benefits of air quality policies targeting O3, health co-benefits of climate mitigation policies, and health implications of climate change-driven changes in O3 concentrations, are larger than previously thought. https://doi.org/10.1289/EHP1390 Received: 17 November 2016 Revised: 19 June 2017 Accepted: 20 June 2017 Published: 28 August 2017 Address correspondence to C.S. Malley, Stockholm Environment Institute, Environment Dept., Environment Building, Wentworth Way, University of York, York, YO10 5NG, UK. Telephone: 44 1904 323685. Email: chri...
Source: EHP Research - August 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Arsenic and Obesity: A Comparison of Urine Dilution Adjustment Methods
Conclusions: Our findings suggest that arsenic exposure is not associated with obesity, and that urinary creatinine and osmolality may be colliders on the causal pathway from arsenic exposure to obesity, as common descendants of hydration and body composition. In studies of urinary biomarkers and obesity or obesity-related outcomes, alternative metrics such as urinary flow rate or analytic strategies such as covariate-adjusted standardization should be considered. https://doi.org/10.1289/EHP1202 Received: 07 October 2016 Revised: 21 March 2017 Accepted: 30 March 2017 Published: 28 August 2017 Address correspondence t...
Source: EHP Research - August 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study
Author Affiliations open 1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China 2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA 3Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA 4Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA 5Department of Biostatistics, Harvard T.H. Chan School of Public Hea...
Source: EHP Research - August 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Urinary Concentrations of Organophosphate Flame Retardant Metabolites and Pregnancy Outcomes among Women Undergoing in Vitro Fertilization
Conclusions: Using IVF to investigate human reproduction and pregnancy outcomes, we found that concentrations of some urinary PFR metabolites were negatively associated with proportions of successful fertilization, implantation, clinical pregnancy, and live birth. https://doi.org/10.1289/EHP1021 Received: 26 August 2016 Revised: 10 April 2017 Accepted: 02 June 2017 Published: 25 August 2017 Address correspondence to C. Carignan, Department of Environmental Health, Building 1, 14th Floor, 665 Huntington Avenue, Boston, MA 02115 USA. Phone: (617) 432-4572. Email: carignan@hsph.harvard.edu Supplemental Material is avail...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

A Method for Identifying Prevalent Chemical Combinations in the U.S. Population
Conclusions: We demonstrated how FIM can be used in conjunction with biomonitoring data to narrow a large number of possible chemical combinations down to a smaller set of prevalent chemical combinations. https://doi.org/10.1289/EHP1265 Received: 24 October 2016 Revised: 17 April 2017 Accepted: 19 April 2017 Published: 24 August 2017 Address correspondence to D.F. Kapraun, National Center for Computational Toxicology, U.S. Environmental Protection Agency, Mail Drop D143-02, 109 T.W. Alexander Dr., Research Triangle Park, NC 27711 USA. Phone: (919) 541-4045. Fax: (919) 541-1194. Email: kapraun.dustin@epa.gov Supplemen...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Erratum: “Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation”
PDF Version (176 KB) About This Article Received: 26 June 2017 Revised: 26 June 2017 Accepted: 29 June 2017 Published: 24 August 2017 Environ Health Perspect 125(6):067002 (2017), https://doi.org/10.1289/EHP347 Address correspondence to R. Gondalia, University of North Carolina, Dept. of Epidemiology, 137 East Franklin Street, Chapel Hill, NC 27514 USA. Phone: (919) 966-1967. Fax: (919) 966-6650. Email: rahgonda@unc.edu Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP&n...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Erratum Source Type: research

Toward Consistent Methodology to Quantify Populations in Proximity to Oil and Gas Development: A National Spatial Analysis and Review
Conclusions: The well inventory guidelines we present provide an improved methodology for hydrocarbon proximity studies by acknowledging the importance of both conventional and unconventional well counts as well as the relative exposure risks associated with different primary production categories (e.g., oil, wet gas, dry gas) and developmental stages of wells. https://doi.org/10.1289/EHP1535 Received: 21 December 2016 Revised: 30 May 2017 Accepted: 05 June 2017 Published: 23 August 2017 Address correspondence to S.B.C. Shonkoff, 1440 Broadway, Suite 205, Oakland, CA 94612 USA. Phone: (510) 899-9706. Email: sshonkoff...
Source: EHP Research - August 24, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants
Conclusions: Our estimates corroborate reports from several recent epidemiological studies of associations between PBDE exposures and neurobehavioral outcomes, and they support the inclusion of BDE-209 in the persistent organic pollutant (POP) convention as well as the need for strategies to reduce exposures to PBDE mixtures, including maximum residue limits for PBDEs in food and measures for limiting the release of PBDEs from consumer waste. https://doi.org/10.1289/EHP826 Received: 18 July 2016 Revised: 06 May 2017 Accepted: 09 May 2017 Published: 23 August 2017 Address correspondence to A. Kortenkamp, Brunel Univer...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride
Conclusions: Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404 Received: 22 November 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 22 August 2017 Address correspondence to G. Cortopassi, 1089 Veterinary Medicine Drive, Davis, CA 95616 USA. Phone: (530)...
Source: EHP Research - August 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice
Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329 Received: 04 November 2016 Revised: 11 April 2017 Accepted: 13 April 2017 Published: 21 August 2017 Address correspondence to D. deCatanzaro, Dept. of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main St. West, Hamilton ON L8S 4K1, Canada. Telephone: (905) 525-9140, ext. 23014. Email: decatanz@mcmaster.ca Supplemental Material is available online (https://doi.org/10.1289/EHP...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study
We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men. Methods: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004–2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Air Pollution and Risk of Parkinson ’s Disease in a Large Prospective Study of Men
Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD in men. https://doi.org/10.1289/EHP259 Received: 01 April 2016 Revised: 07 November 2016 Accepted: 10 November 2016 Published: 18 August 2017 Address correspondence to N. Palacios, Dept. of Public Health, University of Massachusetts, Lowell; Lowell, Massachusetts. Telephone: 617-304-4254. Email: natalia_palacios@uml.edu Statistical analysis was done by N.P. and K.C.F. The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensu...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Review of Epidemiological Studies of Drinking-Water Turbidity in Relation to Acute Gastrointestinal Illness
Conclusions: The observed associations suggest a detectable incidence of waterborne AGI from drinking water in the systems and time periods studied. However, some discrepant results indicate that the association may be context specific. Combining turbidity with seasonal and climatic factors, additional water quality measures, and treatment data may enhance predictive modeling in future studies. https://doi.org/10.1289/EHP1090 Received: 12 September 2016 Revised: 24 February 2017 Accepted: 27 February 2017 Published: 17 August 2017 Address correspondence to A.J. De Roos, Nesbitt Hall, Room 658, 3215 Market St., Philad...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Outdoor Light at Night and Breast Cancer Incidence in the Nurses ’ Health Study II
Conclusions: Although further work is required to confirm our results and to clarify potential mechanisms, our findings suggest that exposure to residential outdoor light at night may contribute to invasive breast cancer risk. https://doi.org/10.1289/EHP935 Received: 08 August 2016 Revised: 17 March 2017 Accepted: 20 March 2017 Published: 17 August 2017 Address correspondence to P. James, 401 Park Dr., 3rd Floor West, Boston, MA 02215 USA. Telephone: (617) 525-2567; Email: pjames@hsph.harvard.edu Supplemental Material is available online (https://doi.org/10.1289/EHP935). The authors declare they have no actual or pot...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Adaptation to Climate Change: A Comparative Analysis of Modeling Methods for Heat-Related Mortality
Conclusions: Researchers should carefully consider how to model adaptation because it is a source of uncertainty that can be greater than the uncertainty in emissions and climate modeling. We recommend absolute threshold shifts and reductions in slope. https://doi.org/10.1289/EHP634 Received: 09 June 2016 Revised: 15 September 2016 Accepted: 24 October 2016 Published: 16 August 2017 Address correspondence to S.N. Gosling, School of Geography, University of Nottingham, Nottingham NG7 2RD, UK. Telephone: +44(0)115 951 5437. Email: simon.gosling@nottingham.ac.uk Supplemental Material is available online (https://doi.org...
Source: EHP Research - August 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research