Teenager who lost his leg to a bone cancer has a new knee formed from his backwards FOOT
Jacob Bredenhof, 14, from Canada, was found to have cancerous tumours in his thigh. He had the cancer-ridden bone removed, before rotationplasty to replace his knee with his ankle. (Source: the Mail online | Health)
Source: the Mail online | Health - February 25, 2019 Category: Consumer Health News Source Type: news

Teenager's last words before she died of cancer that returned THREE weeks after the all-clear
Daisy Wyatt, 14, of Blackwood, Wales, finished treatment for rare bone cancer in 2016 after diagnosis at 12 years old. But the family were soon told it had spread to her lungs and was incurable. (Source: the Mail online | Health)
Source: the Mail online | Health - February 22, 2019 Category: Consumer Health News Source Type: news

Mark Kelly Isn ’t the First Astronaut to Consider a Political Campaign. But Most Didn’t Have the Right Stuff
Most people go through their entire lives without checking any of the major fame boxes. In a nation of 325 million people, there are only so many NFL quarterbacks, Oscar winners and Nobel laureates. There are only so many astronauts and elected officials, too — so it’s especially rare when someone tries to succeed at both gigs. Mark Kelly, onetime NASA astronaut and husband of former Congresswoman Gabrielle Giffords, is going for just that twofer, with his Feb. 12 announcement that he will run for a U.S. Senate seat in Arizona during the 2020 cycle. Kelly, a Democrat, will be seeking to defeat incumbent GOP Sen...
Source: TIME: Science - February 13, 2019 Category: Science Authors: Jeffrey Kluger Tags: Uncategorized onetime space Source Type: news

The Patient Had Bone Cancer. The Diagnosis Arrived 240 Million Years Too Late.
The fossil of an ancient animal teaches a sad lesson: Cancer has been around for a very, very long time. (Source: NYT Health)
Source: NYT Health - February 7, 2019 Category: Consumer Health News Authors: ASHER ELBEIN Tags: Bone Cancer Tumors Turtles and Tortoises Fossils Paleontology Reptiles Charite Universitatsmedizin (Berlin, Germany) JAMA Oncology (Journal) Museum of Natural History (Berlin, Germany) Berlin (Germany) your-feed-science Source Type: news

A family ’s $1.6 million fight against cancer
The Jacquie Hirsch For A.L.L. Foundation works to promote awareness and testing for bone marrow transplants in the hopes of helping people with bone cancer find a match. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 7, 2019 Category: Pharmaceuticals Authors: Tracey Drury Source Type: news

Case study documents bone cancer in 240-million-year-old stem-turtle
(JAMA Network) This research letter documents bone cancer in a 240-million-year-old stem-turtle from the Triassic period, helping to provide more data about the history of cancer in tetrapod evolution. This is a case study about a highly malignant bone tumor on the femur of a shell-less stem-turtle. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 7, 2019 Category: Cancer & Oncology Source Type: news

Canine Bone Cancer Vaccine Hints at a Human Version
TUESDAY, Feb. 5, 2019 -- An experimental vaccine for bone cancer in dogs could offer a road map for a human version of the treatment, researchers report. More than 10,000 cases of bone cancer in dogs occur in the United States each year. But the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 5, 2019 Category: General Medicine Source Type: news

Canine Bone Cancer Vaccine Hints at a Human Version
Title: Canine Bone Cancer Vaccine Hints at a Human VersionCategory: Health NewsCreated: 2/5/2019 12:00:00 AMLast Editorial Review: 2/5/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - February 5, 2019 Category: Cancer & Oncology Source Type: news

Canine Bone Cancer Vaccine Hints at a Human Version
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - February 5, 2019 Category: Cancer & Oncology Source Type: news

New precision medicine procedure fights cancer, advances treatment for pets and humans
(University of Missouri-Columbia) In a first-of-its-kind study, scientists at the University of Missouri have helped advance a patient-specific, precision medicine treatment for bone cancer in dogs. By creating a vaccine from a dog's own tumor, scientists worked with ELIAS Animal Health to target specific cancer cells and avoid the toxic side effects of chemotherapy, while also opening the door for future human clinical trials. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2019 Category: International Medicine & Public Health Source Type: news

WATCH: What is Ewing sarcoma?
Ewing sarcoma is a rare type of cancer occurring in the bones or in the soft tissue around the bones. (Source: ABC News: Health)
Source: ABC News: Health - January 28, 2019 Category: Consumer Health News Tags: Health Source Type: news

High-Dose Chemo and Stem-Cell Rescue for Ewing Sarcoma High-Dose Chemo and Stem-Cell Rescue for Ewing Sarcoma
Consolidation high-dose chemotherapy with busulfan and melphalan may better survival in patients with Ewing sarcoma at high risk for relapse.Journal of Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 11, 2019 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Teenage rugby player loses his leg to cancer six years after his mother's death
Olly Liddle, from Whitley Bay near Newcastle, had to have his right leg cut off above the knee because of osteosarcoma, a rare type of cancer in the bone. His mother, Kerrie, died of breast cancer in 2012. (Source: the Mail online | Health)
Source: the Mail online | Health - December 6, 2018 Category: Consumer Health News Source Type: news

Cancer survivor, 25, to have a pioneering operation to REVERSE her early menopause
Adele Stevens, from Reading, is said to be the 'second patient' to undergo ovarian cryopreservation to restore fertility, after chemotherapy for bone cancer gave her the menopause 20 years early. (Source: the Mail online | Health)
Source: the Mail online | Health - November 26, 2018 Category: Consumer Health News Source Type: news

Duke doctor's search for cancer cure lands in unlikely place – studying dogs
Dr. Will Eward spends the first three days of his week treating patients at Duke Cancer Institute, including those facing a rare cancer that starts in the bones called osteosarcoma. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 23, 2018 Category: American Health Authors: Dane Huffman Source Type: news

Duke doctor's search for cancer cure lands in unlikely place – studying dogs
Dr. Will Eward spends the first three days of his week treating patients at Duke Cancer Institute, including those facing a rare cancer that starts in the bones called osteosarcoma. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 23, 2018 Category: Biotechnology Authors: Dane Huffman Source Type: news

Duke doctor's search for cancer cure lands in unlikely place
Dr. Will Eward spends the first three days of his week treating patients at Duke Cancer Institute, including those facing a rare cancer that starts in the bones called osteosarcoma. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 21, 2018 Category: American Health Authors: Dane Huffman Source Type: news

Four-year-old was diagnosed with cancer after doctors dismissed his weeping eye as a cold  
Harri Cooke, from Tewkesbury, Gloucestershire, was a happy toddler before his mother, Carly, 33, noticed he had a weeping eye. He was later diagnosed with Ewing ’s Sarcoma (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news

Four-year-old was diagnosed with cancer after doctors dismissed his weeping eye as a cold 
Harri Cooke, from Tewkesbury, Gloucestershire, was a happy toddler before his mum, Carly, 33, noticed he had a weeping eye. He was later diagnosed with Ewing’s Sarcoma (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news

Man is forced to have his leg amputated after developing cancer
Matthew King, from North Yorkshire, was rushed to Darlington Memorial Hospital where he was diagnosed with Ewing Sarcoma -  a rare form of cancer that typically affects young men. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2018 Category: Consumer Health News Source Type: news

Man is forced to have his leg amputated after developing cancer
Matthew King, from North Yorkshire, was rushed to Darlington Memorial Hospital where he was diagnosed with Ewing Sarcoma - a rare form of cancer that typically affects young men. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2018 Category: Consumer Health News Source Type: news

Alex Huang, M.D., Ph.D., awarded $1.35 million to conduct lifesaving childhood cancer research
(Case Western Reserve University) Leading cancer researcher, Alex Huang M.D., Ph.D., has been awarded a three-year, $1.35 million grant from the St. Baldrick's Foundation and the Osteosarcoma Collaborative to develop new ways to treat osteosarcoma, a rare cancer that begins in the bone. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2018 Category: International Medicine & Public Health Source Type: news

Are We Underdosing Patients With Ewing Sarcoma?
A new study evaluated whether busulfan and melphalan improve EFS and OS when given after vincristine, ifosfamide, doxorubicin, and etoposide induction. (Source: CancerNetwork)
Source: CancerNetwork - October 25, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Time to Rethink Chemo Doses in High-Risk, Localized Ewing Sarcoma?
A new study evaluated whether busulfan and melphalan improve EFS and OS when given after vincristine, ifosfamide, doxorubicin, and etoposide induction. (Source: CancerNetwork)
Source: CancerNetwork - October 23, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

WATCH: Purdue superfan inspires team's unlikely win over Ohio State
Tyler Trent, 20, a Purdue sophomore, has terminal bone cancer and was invited by the team to address the players in the locker room. (Source: ABC News: Health)
Source: ABC News: Health - October 22, 2018 Category: Consumer Health News Tags: GMA Source Type: news

New clinical trials seek treatments for canine cancers, may offer clues on human cancers
(Tufts University) Two studies into deadly cancers in dogs are now underway, offered through the newly formed Clinical Trials Office at Cummings Veterinary Medical Center at Tufts University. Dogs with spontaneous osteosarcoma, as well as dogs with mast cell tumors and solid tumors, may be eligible for enrollment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 11, 2018 Category: Cancer & Oncology Source Type: news

'My jaw was reconstructed from my shoulder'
When Jen Taylor was diagnosed with bone cancer, she underwent 16 hours of surgery. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 28, 2018 Category: Consumer Health News Source Type: news

Brave eight-year-old boy battles second bout of brain cancer since he was just two
Jaxon Dugger, eight, from Hollis, Oklahoma, was fist diagnosed with Ewing sarcoma when he was just two years old. Three months after being declared cancer-free, his tumor returned. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2018 Category: Consumer Health News Source Type: news

Dancer, 12, who lost leg to rare bone cancer undergoes operation to turn her ankle into a KNEE
Delaney Unger, 12, from Selden, New York, was diagnosed with osteosarcoma, a type of bone cancer, in December 2016 and was told that part of her leg would need to be amputated. (Source: the Mail online | Health)
Source: the Mail online | Health - September 10, 2018 Category: Consumer Health News Source Type: news

Children's bone cancers could remain hidden for years before diagnosis
(Wellcome Trust Sanger Institute) Scientists have discovered that some childhood bone cancers start growing years before they are diagnosed. Researchers at the Wellcome Sanger Institute, UK and Hospital for Sick Children (SickKids), Canada discovered large-scale genetic rearrangements in Ewing Sarcomas and other children's cancers, and showed these can take years to form. The study in Science will help unravel causes of childhood cancers and could help find ways to diagnose and treat these cancers earlier in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 30, 2018 Category: Cancer & Oncology Source Type: news

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors
Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between EWSR1, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when EWSR1-ETS fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex, loop-like rearrangements, a process called chromoplexy, rather than by simple reciprocal translocations. These loops always contained the disease-defining fusion at the center, but they disrupted multiple additional genes....
Source: ScienceNOW - August 30, 2018 Category: Science Authors: Anderson, N. D., de Borja, R., Young, M. D., Fuligni, F., Rosic, A., Roberts, N. D., Hajjar, S., Layeghifard, M., Novokmet, A., Kowalski, P. E., Anaka, M., Davidson, S., Zarrei, M., Id Said, B., Schreiner, L. C., Marchand, R., Sitter, J., Gokgoz, N., Brun Tags: Genetics, Medicine, Diseases, Online Only r-articles Source Type: news

Modern myths about cancer – from ‘chemicals’ in food to wifi
The idea that lifestyle changes have made the disease more common is a gross exaggeration – but increasingly prevalent. We separate fact from fictionCancer is not up there withthe most likely explanations for what caused the mass extinction 66m years ago of the T rex and the triceratops. That said, at leastone species of dinosaur suffered from blood-vessel tumours – anda 1.7m-year-old toe with bone cancer was discovered in 2016 at a South African world heritage site.Cancer may have been more common in ancient times than we will ever know, because fossilisation will have obliterated most evidence of the disease....
Source: Guardian Unlimited Science - August 20, 2018 Category: Science Authors: Naomi Elster Tags: Cancer research Health & wellbeing Society Medical research Science Life and style Source Type: news

MGH team defines the mechanisms of action of key genetic abnormality in Ewing sarcoma
(Massachusetts General Hospital) A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma -- the second most common bone cancer in children and young adults -- unleashes tumor growth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 2, 2018 Category: Cancer & Oncology Source Type: news

Modeling chemotherapy-induced stress to identify rational combination therapies in the DNA damage response pathway
Cells respond to DNA damage by activating complex signaling networks that decide cell fate, promoting not only DNA damage repair and survival but also cell death. We have developed a multiscale computational model that quantitatively links chemotherapy-induced DNA damage response signaling to cell fate. The computational model was trained and calibrated on extensive data from U2OS osteosarcoma cells, including the cell cycle distribution of the initial cell population, signaling data measured by Western blotting, and cell fate data in response to chemotherapy treatment measured by time-lapse microscopy. The resulting mecha...
Source: Signal Transduction Knowledge Environment - July 24, 2018 Category: Science Authors: Alkan, O., Schoeberl, B., Shah, M., Koshkaryev, A., Heinemann, T., Drummond, D. C., Yaffe, M. B., Raue, A. Tags: STKE Research Articles Source Type: news

Medical News Today: What is osteosarcoma?
Osteosarcoma is a type of bone cancer that often affects the shinbone, thighbone, or upper arm. Doctors are currently unsure of the causes, but genetics may play a role. Treatment includes chemotherapy and surgery. The outlook depends on if and how far cancerous cells have spread. Learn more about osteosarcoma here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 23, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Emma Neagu had her foot fitted backwards after having bone cancer
Emma Neagu, now 14, from Toronto, was diagnosed with a form of bone cancer known as osteosarcoma in 2016. The teen endured nine months of grueling chemotherapy. (Source: the Mail online | Health)
Source: the Mail online | Health - July 23, 2018 Category: Consumer Health News Source Type: news

Gymnast, 14, chose to have her foot removed and refitted backwards after developing bone cancer
Emma Neagu, now 14, from Toronto, was diagnosed with a form of bone cancer known as osteosarcoma in 2016. The teen endured nine months of grueling chemotherapy. (Source: the Mail online | Health)
Source: the Mail online | Health - July 23, 2018 Category: Consumer Health News Source Type: news

Products of omega-3 fatty acid metabolism may have anticancer effects, study shows
(University of Illinois at Urbana-Champaign) A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer's growth and spread, University of Illinois researchers report in a new study in mice. In mice with tumors of osteosarcoma - a bone cancer that is notoriously painful and difficult to treat -- endocannabinoids slowed the growth of tumors and blood vessels, inhibited the cancer cells from migrating and caused cancer cell death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 13, 2018 Category: International Medicine & Public Health Source Type: news

Olathe biotech moves dog cancer treatment closer to market
A Kansas City-area animal health company is ramping up its efforts to take its cancer immunotherapy treatment to market. Elias Animal Health, a subsidiary of Olathe-based TVAX Biomedical Inc., applied for a conditional licensure of its treatment for dogs with bone cancer through the U.S. Department of Agriculture’s Center for Veterinary Biologics. Elias recently completed preliminary studies of its osteosarcoma treatment and will enroll for a pivotal study as the next step. On Thursday, the… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 14, 2018 Category: American Health Authors: Elise Reuter Source Type: news

Genetic discovery will help clinicians identify aggressive versus benign bone tumors
(Wellcome Trust Sanger Institute) The first genetic marker for the bone tumor, osteoblastoma, has been discovered by scientists at the Wellcome Sanger Institute and their collaborators. Whole-genome and transcriptome sequencing of human bone tumors revealed that a genetic change that affects the transcription factor, FOS, is a hallmark mutation of osteoblastoma. The results, published in Nature Communications, will help clinicians correctly distinguish benign osteoblastoma tumors from aggressive osteosarcoma tumors and direct the correct treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 12, 2018 Category: Cancer & Oncology Source Type: news

Bone cancer symptoms: Watch out for these less common arthritis-like symptoms
BONE cancer symptoms include aching within the bones, which can be mistaken for arthritis. However, there are also three other symptoms, according to the NHS. (Source: Daily Express - Health)
Source: Daily Express - Health - May 26, 2018 Category: Consumer Health News Source Type: news

Medical News Today: What could cause bone pain?
People may feel aches or pains in their bones for a variety of reasons. Many people worry when they experience bone pain because it can be a sign of bone cancer. For this reason, prompt diagnosis is essential. Learn more about bone pain symptoms, the signs of cancer, and when to see a doctor. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2018 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Innovative vaccine offers canine cancer patients a shot at a longer, happier life
(University of Pennsylvania) Nicola Mason of the School of Veterinary Medicine is leading a multi-institutional clinical trial evaluating an immunotherapy approach to treat dogs with osteosarcoma, a cancer of the bone. A new $775,000 grant from the Morris Animal Foundation will help her build on her past successes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 1, 2018 Category: Cancer & Oncology Source Type: news

Girl has leg reattached backwards after cancer surgery
Amelia Eldred who lost her limb to bone cancer has rare procedure which could allow her to dance again. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 25, 2018 Category: Consumer Health News Source Type: news

New connections: Ewings sarcomas driver is its Achilles heel
Several studies identify drug combinations that target or exploit the EWS-FLI1 fusion protein to kill Ewing’s sarcoma cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 24, 2018 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news

The inspirational reason girl, 7, who lost her leg to cancer had her limb attached BACKWARDS
Amelia Eldred, 7, from Tamworth, had her left leg amputated because of a rare form of bone cancer, but her lower leg has been reattached so her ankle can act as a knee when she gets a prosthetic leg. (Source: the Mail online | Health)
Source: the Mail online | Health - April 20, 2018 Category: Consumer Health News Source Type: news

Morris Animal Foundation awards $775K to test osteosarcoma immunotherapy vaccine in dogs
(Morris Animal Foundation) Morris Animal Foundation has awarded a $775,000 grant to the University of Pennsylvania to test a vaccine that could improve longevity and quality of life for dogs with the deadly bone tumor, osteosarcoma. The research team will conduct clinical trials to evaluate a novel immunotherapy treatment which combines a molecule expressed by cancer cells with a modified live form of the bacteria Listeria monocytogenes. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 17, 2018 Category: Biology Source Type: news

Pregnant woman, 29, diagnosed with terminal cancer after scan 17 weeks into her first pregnancy
Laura King, a nursery director from Surrey, beat breast cancer in 2017. After the all-clear, she and her husband decided to start a family. Weeks later, she was diagnosed with secondary bone cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - April 13, 2018 Category: Consumer Health News Source Type: news

A potential new therapeutic target for Ewing sarcoma
(IDIBELL-Bellvitge Biomedical Research Institute) IDIBELL researchers correlate EphA2 membrane receptor with the metastatic capacity of tumors in Ewing sarcoma.Ewing sarcoma is the second most frequent bone cancer among children and adolescents, and it is characterized by its aggressiveness and tendency to metastasize.Researchers are currently working on nanoengineering a molecule capable of blocking EphA2 and deliver drugs in a targeted manner.Research was possible thanks to the backing of Alba P é rez Foundation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 5, 2018 Category: Cancer & Oncology Source Type: news