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HKBU Chinese medicine scholars develop HKBU Chinese medicine scholars develop
(Hong Kong Baptist University) Chinese Medicine scholars at Hong Kong Baptist University (HKBU) have succeeded in developing a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma (OS). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 10, 2017 Category: International Medicine & Public Health Source Type: news

With three products out, Aratana chases its fourth: a canine cancer drug
With its third FDA-approved drug on the market, Aratana Therapeutics is hunting its next product, a canine cancer immunotherapy treatment. The treatment, called AT-014, would be used to treat bone cancer, or osteosarcoma, in dogs. After a tumor is removed, a vaccine is used to prime the dog’s immune system to target any remaining cancer. Aratana (Nasdaq: PETX) expects to obtain conditional licensure for the treatment from the U.S . Department of Agriculture before the end of 2017, which would… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 7, 2017 Category: Pharmaceuticals Authors: Elise Reuter Source Type: news

Two classes of GGAA-microsatellites in a Ewing sarcoma context
(Nationwide Children's Hospital) In a study published in PLOS ONE, researchers describe two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma. Ewing sarcoma is the second most common pediatric bone malignancy. It is initiated by chromosomal translocation t(11;22)(q24;q12), which creates the fusion protein and oncogenic driver EWS/FLI. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2017 Category: Cancer & Oncology Source Type: news

Just-in-time 3-D implants set to transform tumor surgery
(RMIT University) The project team will combine 3-D printing, robotic surgery and advanced manufacturing to create tailored implants for patients with bone cancer, dramatically improving patient and healthcare outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2017 Category: Cancer & Oncology Source Type: news

Three of the most deadly cancers get critical funding for research
Immunotherapy for leukemia patients has been nothing short of a miracle. Now scientists hope to use that science and other forms of gene therapy to tackle three of the deadliest forms of cancer: glioblastoma (brain cancer), sarcoma (bone cancer) and ovarian cancer. Three scientists have received $1.3 million in critical funding from the Alliance for Cancer Gene Therapy (ACGT), the nation's only nonprofit dedicated exclusively to cell and gene therapies for cancer. (Source: World Pharma News)
Source: World Pharma News - October 18, 2017 Category: Pharmaceuticals Tags: Featured Development Research and Development Source Type: news

Living With Cancer: Cancer Humor
Cracking up may be a better option than breaking down, or so three recent books by young people with cancer suggest. (Source: NYT Health)
Source: NYT Health - October 12, 2017 Category: Consumer Health News Authors: SUSAN GUBAR Tags: Breast Cancer Books and Literature Ewing's Sarcoma (Disease) Comedy and Humor Riggs, Nina (1977-2017) Harrison, Teva (1976- ) Ritvo, Max (1990-2016) Source Type: news

New drug hope for rare bone cancer patients
Patients with a rare bone cancer of the skull and spine - chordoma - could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust. In the largest genomics study of chordoma to date, published today in Nature Communications, scientists show that a group of chordoma patients have mutations in genes that are the target of existing drugs, known as PI3K inhibitors. (Source: World Pharma News)
Source: World Pharma News - October 12, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

New drug hope for rare bone cancer patients
(Wellcome Trust Sanger Institute) Patients with a rare bone cancer of the skull and spine -- chordoma -- could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust. In the largest genomics study of chordoma to date, published today in Nature Communications, scientists show that a group of chordoma patients have mutations in genes that are the target of existing drugs, known as PI3K inhibitors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 12, 2017 Category: Cancer & Oncology Source Type: news

WATCH: Friends 'just keep swimming,' despite blindness and bone cancer
Two teenagers swim together and support each other as one faces progressive blindness and the other fights bone cancer. (Source: ABC News: Health)
Source: ABC News: Health - October 10, 2017 Category: Consumer Health News Tags: GMA Source Type: news

Friends 'just keep swimming' despite blindness and bone cancer
Two teenagers swim together and support each other as they face progressive blindness and bone cancer, respectively. (Source: ABC News: Health)
Source: ABC News: Health - October 10, 2017 Category: Consumer Health News Tags: Health Source Type: news

WATCH: Friends "Just Keep Swimming" despite blindness and bone cancer
Two teenagers swim together and support each other as one faces progressive blindness and the other fights bone cancer. (Source: ABC News: Health)
Source: ABC News: Health - October 10, 2017 Category: Consumer Health News Tags: GMA Source Type: news

Two agents deliver knockout punches to Ewing sarcoma
(Georgetown University Medical Center) When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 3, 2017 Category: Cancer & Oncology Source Type: news

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewings sarcoma
Ewing’s sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated in driving most ES cases by modulation of transcription and alternative splicing. The small-molecule YK-4-279 inhibits EWS-FLI1 function and induces apoptosis in ES cells. We aimed to identify both the underlying mechanism of the drug and potential combination therapies that might enhance its...
Source: Signal Transduction Knowledge Environment - October 3, 2017 Category: Science Authors: Zöllner, S. K., Selvanathan, S. P., Graham, G. T., Commins, R. M. T., Hong, S. H., Moseley, E., Parks, S., Haladyna, J. N., Erkizan, H. V., Dirksen, U., Hogarty, M. D., Üren, A., Toretsky, J. A. Tags: STKE Research Articles Source Type: news

i-Fect Delivers Plasmids!
Important for Gene Expression Studies.I have posted many examples of how our customers usei-FectTM  and otherTransfection Solutions for Gene Manipulation Studies. There are also manypublications.Here we feature how i-Fect was used to delivery plasmids to the CNS: Sara Elramah, Mar ía José López-González, Matthieu Bastide, Florence Dixmérias, Olivier Roca-Lapirot, Anne-Cécile Wielanek-Bachelet, Anne Vital, Thierry Leste-Lasserre, Alexandre Brochard, Marc Landry& Alexandre Favereaux.Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone ...
Source: Neuromics - September 21, 2017 Category: Neuroscience Tags: Bone Cancer Pain cancer biology iFect Plasmids Transfection Reagents Source Type: news

i-Fect Deliver Plasmids to the CNS
Important for Gene Expression Studies.I have posted many examples of how our customers usei-FectTM  and otherTransfection Solutions for Gene Manipulation Studies. There are also manypublications.Here we feature how i-Fect was used to delivery plasmids to the CNS: Sara Elramah, Mar ía José López-González, Matthieu Bastide, Florence Dixmérias, Olivier Roca-Lapirot, Anne-Cécile Wielanek-Bachelet, Anne Vital, Thierry Leste-Lasserre, Alexandre Brochard, Marc Landry& Alexandre Favereaux.Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone ...
Source: siRNA and DsiRNA Transfection Efficiency - September 21, 2017 Category: Neuroscience Tags: C iFect Plasmid Transfection Plasmid Vector shRNA plasmids Source Type: news

Jess Quinn who lost her leg to bone cancer talks struggles
Jessica Quinn, from New Zealand, who lost her leg to cancer has opened up about her struggles with body image - and how she was able to bounce back by embracing her  prosthetic limb. (Source: the Mail online | Health)
Source: the Mail online | Health - July 31, 2017 Category: Consumer Health News Source Type: news

Osteosarcoma and Malignant Fibrous Histiocytoma
of Bone (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 31, 2017 Category: General Medicine Source Type: news

Leicester cancer boy heading home after treatment in US
Alex Goodwin, from Rugby, England, was diagnosed with Ewing's Sarcoma last year after months of agony in his joints and muscles. He finished treatment earlier this month and is headed home in August. (Source: the Mail online | Health)
Source: the Mail online | Health - July 28, 2017 Category: Consumer Health News Source Type: news

Elevated cholesterol's link with canine cancer includes a better prognosis
(Oregon State University) Usually thought of as a health detriment, elevated cholesterol may play a role in longer survival times for dogs with a common form of bone cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 25, 2017 Category: Cancer & Oncology Source Type: news

Dogs assist the fight against bone cancer
Comparative oncology, a rapidly-growing field of cancer research, pairs veterinarians with human doctors in the fight against cancer. Because certain cancers in dogs and people share striking similarities, the hope is that a new treatment for dogs, if successful, could be applied to people, too. Susan Spencer reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - July 23, 2017 Category: Consumer Health News Source Type: news

On The Horizon: How dogs may help fight bone cancer
Veterinarians team up with cancer doctors in the field of comparative oncology to find a cure for osteosarcoma (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - July 22, 2017 Category: Consumer Health News Source Type: news

Tumor-targeting drug shows potential for treating bone cancer patients
(University of Texas M. D. Anderson Cancer Center) The treatment of osteosarcoma, the most common tumor of bone, is challenging. A study led by The University of Texas MD Anderson Cancer Center found a drug known as bone metastasis-targeting peptidomimetic (BMTP-11) has potential as a new therapeutic strategy for this devastating illness. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 12, 2017 Category: International Medicine & Public Health Source Type: news

Guildford teen discovers 'pulled muscle' was bone cancer
Faye Lucas, 19, from Guildford, put off going to the doctors  for more than 12 months as she put her difficulty bending her leg down to a strain. Doctors discovered she had a form of osteosarcoma. (Source: the Mail online | Health)
Source: the Mail online | Health - July 11, 2017 Category: Consumer Health News Source Type: news

Promising new therapeutic approach for debilitating bone disease
(Garvan Institute of Medical Research) Australian researchers have demonstrated that a new type of therapeutic could greatly reduce bone disease in patients with the bone cancer, multiple myeloma. Multiple myeloma is a cancer that develops in bone, causing progressive bone destruction, bone fractures, and often devastating pain. Unlike existing treatments, this new approach rebuilds bone tissue, making it more resistant to fractures.This treatment could greatly reduce the debilitating pain of bone damage, transforming the prognosis for myeloma patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 29, 2017 Category: International Medicine & Public Health Source Type: news

The Brisbane boy with an upside down foot
Jonty Oddy, from Brisbane, Australia, was an active four-year-old, when he suddenly started limping as he walked. Doctors discovered his pained stemmed from an osteosarcoma. (Source: the Mail online | Health)
Source: the Mail online | Health - June 27, 2017 Category: Consumer Health News Source Type: news

What is bone cancer? Symptoms could be mistaken for THIS common condition
BONE cancer is a rare type of cancer - it affects just over 500 people every year. (Source: Daily Express - Health)
Source: Daily Express - Health - June 23, 2017 Category: Consumer Health News Source Type: news

Existing drugs could benefit patients with bone cancer, genetic study suggests
(Wellcome Trust Sanger Institute) A subgroup of patients with osteosarcoma -- a form of bone cancer -- could be helped by an existing drug, suggest scientists from the Wellcome Trust Sanger Institute and their collaborators. In the largest genetic sequencing study of osteosarcoma to date, scientists discovered that 10 percent of patients with a genetic mutation in particular growth factor signalling genes may benefit from existing drugs, known as IGF1R inhibitors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 23, 2017 Category: Cancer & Oncology Source Type: news

Why Was a Teenager with Bone Cancer Buried on Witch Hill in 1300 AD
Report identifies bone tumor in upper right arm of adolescent buried around 1300 AD at a site in western Panama called Cerro Brujo or Witch Hill (Source: Disabled World)
Source: Disabled World - June 2, 2017 Category: Disability Tags: Anthropology Source Type: news

Why was a teenager with bone cancer buried on Witch Hill in Panama?
(Smithsonian Tropical Research Institute) Likely the first bone tumor from an ancient skeleton in Central America is reported by Smithsonian archaeologists and colleagues. The starburst-shaped tumor is in the upper right arm of the skeleton of an adolescent buried in about 1300 AD in a trash heap at a site in western Panama called Cerro Brujo or Witch Hill. The reason for what appears to be a ritual burial in this abandoned pre-Colombian settlement is unknown. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2017 Category: Cancer & Oncology Source Type: news

CPRIT grant brings personalized-modeling expert to Rice
(Rice University) Thanks to a new $5 million recruitment grant from the Cancer Prevention and Research Institute of Texas, bone cancer patients facing difficult pelvic surgeries in the Texas Medical Center could soon benefit from Rice University research that will use personalized computer models to predict surgical outcomes for patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 18, 2017 Category: International Medicine & Public Health Source Type: news

On Biotech: Aratana primes puppy pharma pipeline
Even as Aratana Therapeutics ramps up marketing for its current portfolio, the Leawood company continues to move new treatments for Fido through its development pipeline. The star of the company’s May 9 investor call was Galliprant, a canine osteoarthritis treatment on its way to becoming a blockbuster. But Aratana’s plans include another treatment for more severe osteoarthritis cases, in addition to an immunotherapy treatment for bone cancer. “Lately, a lot of the focus at Aratana has been… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - May 11, 2017 Category: Health Management Authors: Elise Reuter Source Type: news

On Biotech: Aratana primes puppy pharma pipeline
Even as Aratana Therapeutics ramps up marketing for its current portfolio, the Leawood company continues to move new treatments for Fido through its development pipeline. The star of the company’s May 9 investor call was Galliprant, a canine osteoarthritis treatment on its way to becoming a blockbuster. But Aratana’s plans include another treatment for more severe osteoarthritis cases, in addition to an immunotherapy treatment for bone cancer. “Lately, a lot of the focus at Aratana has been… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 11, 2017 Category: Biotechnology Authors: Elise Reuter Source Type: news

A protein, a 'molecular staple' and CRISPR to develop an Ewing sarcoma model
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing sarcoma. The technique, based on CRISPR and described in the pages of Stem Cell Reports, makes it possible to generate cellular models to analyze the mechanisms underlying the origin and progression of this and other diseases, as well as the search for new treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 10, 2017 Category: International Medicine & Public Health Source Type: news

Tumor Lysis Syndrome in an Extraskeletal Osteosarcoma Tumor Lysis Syndrome in an Extraskeletal Osteosarcoma
Tumor lysis syndrome is a major oncological emergency, usually associated with treatment of hematological tumors. What precipitated it in this patient, and how was it treated?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 5, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

What Charlotte Rae's Cancer Plan Reveals About Medical Decisions Late In Life
Actress Charlotte Rae, 91, has revealed that she was just diagnosed with bone cancer. And like many who get a diagnosis of a serious illness at an advanced age, her first decision wasn’t what the best treatment plan might be but rather whether she should seek treatment at all. “At the age of 91, I have to make up my mind,” she told People magazine. “I’m not in any pain right now. I’m feeling so terrific and so glad to be above ground.” Rae, who was treated for pancreatic cancer several years ago, added, “Now I have to figure out whether I want to go have treatment again ...
Source: Healthy Living - The Huffington Post - April 28, 2017 Category: Consumer Health News Source Type: news

​FDA approves Radius Health osteoporosis drug, but adds cancer warning
The FDA on Friday approved an osteoporosis drug made by Waltham-based Radius Health, but added a so-called "black box" warning that the treatment had increased the risk of bone cancer in rats. Radius (Nasdaq: RDUS) is hoping that abaloparatide, which will be sold under the brand name Tymlos, will eventually take on Forteo, an osteoporosis treatment sold by Eli Lilly (NYSE: LLY) that generated $1.5 billion in sales last year. Forteo has the same warning, which states that the drug increa sed the risk… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 28, 2017 Category: Biotechnology Authors: Max Stendahl Source Type: news

​FDA approves Radius Health osteoporosis drug, but adds cancer warning
The FDA on Friday approved an osteoporosis drug made by Waltham-based Radius Health, but added a so-called "black box" warning that the treatment had increased the risk of bone cancer in rats. Radius (Nasdaq: RDUS) is hoping that abaloparatide, which will be sold under the brand name Tymlos, will eventually take on Forteo, an osteoporosis treatment sold by Eli Lilly (NYSE: LLY) that generated $1.5 billion in sales last year. Forteo has the same warning, which states that the drug increa sed the risk… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - April 28, 2017 Category: American Health Authors: Max Stendahl Source Type: news

Girl With Cancer Receives American Girl Doll With Prosthetic Leg Like Hers
After losing her leg to cancer, a 10-year-old girl found companionship in a special doll with the same condition. In November 2016, Dylan Probe was diagnosed with a type of bone cancer called Ewing’s sarcoma. The fourth-grader had to undergo chemotherapy and on March 17, had her right leg amputated below the knee.   Throughout Dylan’s battle with cancer, photographer Sherina Welch has documented her journey in the hospital. Following the surgery, Welch decided to surprise the brave little girl with an American Girl doll that has a prosthetic leg just like hers. Welch ordered the doll from a company c...
Source: Healthy Living - The Huffington Post - April 14, 2017 Category: Consumer Health News Source Type: news

Cancer survivor climbing a mountain using crutches
A bone cancer survivor has told BBC 5 live she climbed a mountain on crutches (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 14, 2017 Category: Consumer Health News Source Type: news

Adventurer diagnosed with rare form of bone cancer
Adventurer Nikki Bradley, 30, from Ireland was diagnosed with a rare form of bone cancer which means she must use crutches when out exploring. (Source: the Mail online | Health)
Source: the Mail online | Health - April 9, 2017 Category: Consumer Health News Source Type: news

' Jumonji' protein key to Ewing's sarcoma rampage
A new study pinpoints a protein that may be essential to Ewing's sarcoma metastasis -- when researchers knocked down the protein KDM3A in Ewing's sarcoma tumor cells, one of a family known as Jumonji proteins, they also inhibited the cancer's metastatic ability. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 24, 2017 Category: Science Source Type: news

'Jumonji' protein key to Ewing's sarcoma rampage
(University of Colorado Anschutz Medical Campus) A University of Colorado Cancer Center study published in the journal Oncogene pinpoints a protein that may be essential to Ewing's sarcoma metastasis -- when researchers knocked down the protein KDM3A in Ewing's sarcoma tumor cells, one of a family known as Jumonji proteins, they also inhibited the cancer's metastatic ability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 24, 2017 Category: Cancer & Oncology Source Type: news

Early Bone Cancer Symptoms
Title: Early Bone Cancer SymptomsCategory: Doctor's& Expert's views on SymptomsCreated: 7/2/2013 12:00:00 AMLast Editorial Review: 3/17/2017 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - March 17, 2017 Category: Cancer & Oncology Source Type: news

Mechanism triggering spread of prostate cancer to bones found
A researcher has found a way that prostate cancer cells hijack the body's bone maintenance, facilitating the spread of bone cancers present in some 90 percent of prostate-cancer fatalities. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 13, 2017 Category: Science Source Type: news

WSU researcher finds mechanism triggering spread of prostate cancer to bones
(Washington State University) A Washington State University researcher has found a way that prostate cancer cells hijack the body's bone maintenance, facilitating the spread of bone cancers present in some 90 percent of prostate-cancer fatalities. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 13, 2017 Category: Cancer & Oncology Source Type: news

On The Horizon: How dogs may help fight bone cancer
Veterinarians team up with cancer doctors in the field of comparative oncology to find a cure for osteosarcoma (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - March 12, 2017 Category: Consumer Health News Source Type: news

Dogs assist the fight against bone cancer
Comparative oncology, a rapidly-growing field of cancer research, pairs veterinarians with human doctors in the fight against cancer. Because certain cancers in dogs and people share striking similarities, the hope is that a new treatment for dogs, if successful, could be applied to people, too. Susan Spencer reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - March 12, 2017 Category: Consumer Health News Source Type: news

Make the Diagnosis: High-Tech Cancer Care
(MedPage Today) -- Case Findings: A 22-year-old male patient faces a total femur amputation after a diagnosis of Ewing's sarcoma. However, a surgeon was able to preserve his ability to walk. What was the strategy? (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - March 6, 2017 Category: Hematology Source Type: news

Ewing Sarcoma Survivors At Increased Risk for Subsequent Malignancies
Survivors of childhood Ewing sarcoma have substantial risk for late mortality and subsequent neoplasms, according to a long-term follow-up study. (Source: CancerNetwork)
Source: CancerNetwork - March 3, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: News Sarcoma Source Type: news

Bone Cancer Facts
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 27, 2017 Category: Journals (General) Source Type: news