Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems clear that many of the varied approaches to adjusting the operation of metabolism in ways that (usually modestly) slow aging in animal models achieve this outcome by acting on a set of common underlying mechanisms. For example, a great deal of effort has gone towards the study of autophagy in this context, a response to mild stress that improves cell function by recycling damaged molecular machinery. Upregulation of autophagy appears to be a feature of most of the better studied approaches to slowing aging, and certainly those derived from investigations of calorie restriction.
What do more sophisticated efforts to find commonalities between age-slowing interventions look like? Today's open access paper offers some insight into that question. The authors report on an approach to the analysis of omics data from biological samples taken from mice foll...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
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