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Polyethylene Glycol (PEG) and Electrolytes
Title: Polyethylene Glycol (PEG) and ElectrolytesCategory: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 8/8/2017 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - August 8, 2017 Category: Nutrition Source Type: news

Are Biobetters Better?
Biosimilars and biobetters are both variants of a biologic drug, however, while biosimilars are close copies of the originator, biobetters have been improved, for example, in terms of efficacy, safety, tolerability or dosing regimen.Regulators consider biobetters as new products and so afford them the same patent protection as any originator, however, this means they require the same clinical and non-clinical data packages. Conversely, a reduced clinical data package is an attractive element for the development of biosimilars.Given the cost of development and the time pressure to bring a biobetter to market before biosimil...
Source: EyeForPharma - July 3, 2017 Category: Pharmaceuticals Authors: James Wright Source Type: news

Direct Comparison Favors Electrolyte Bowel Prep Direct Comparison Favors Electrolyte Bowel Prep
Polyethylene glycol is a better bowel preparation than sodium picosulfate plus magnesium citrate, and colonoscopy results are best when prep is spread over 2 days, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 16, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Large-volume Regimen Preferred After Previous Poor Bowel Preparation Large-volume Regimen Preferred After Previous Poor Bowel Preparation
An intensified bowel prep regimen that includes split-dose large-volume polyethylene glycol (PEG) is superior to a similar low-volume PEG (plus ascorbic acid) regimen in patients who had inadequate bowel preparation for a previous colonoscopy.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 6, 2017 Category: Pathology Tags: Pathology & Lab Medicine News Source Type: news

Diuretic Use Increases Colonoscopy Patients ’ Risk of Hypokalemia Diuretic Use Increases Colonoscopy Patients ’ Risk of Hypokalemia
Hypokalemia is not uncommon after low-volume PEG (polyethylene glycol) bowel cleansing, particularly in patients who use diuretics, a new report confirms.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 9, 2017 Category: Consumer Health News Tags: News Source Type: news

GoLytely (Polyethylene Glycol 3350 and Electrolytes Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 21, 2017 Category: Drugs & Pharmacology Source Type: news

Study finds higher complication risk with Cardinal Health ’ s Mynx vascular closure device
A study published last week in The New England Journal of Medicine concluded that patients treated with Cardinal Health (NYSE:CAH)’s Mynx vascular closure device are at higher risk for vascular complications compared to patients that received alternative vascular closure devices. The data also suggested that patients who received the Mynx device were at greater risk for access site bleeding and transfusion compared to their counterparts. The team of researchers analyzed data from 73,124 patients who received Mynx devices after percutaneous coronary intervention procedures with femoral access ...
Source: Mass Device - February 1, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Clinical Trials Vascular Wall Street Beat Cardinal Health Source Type: news

NuLytely (Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 12, 2016 Category: Drugs & Pharmacology Source Type: news

Modification to delivery polymer sidesteps allergic response
Researchers from Duke University have reconfigured the popular drug-delivery polymer, polyethylene glycol, to sidestep dangerous immune responses that have previously halted clinical trials at Duke. The team’s work was published in Nature Biomedical Engineering. Polyethylene glycol, PEG, is a polymer that is found in toothpaste and cosmetics, but is often used in pharmaceuticals. It can be attached to active drugs in the bloodstream, thus slowing the body’s ability to clear them and lengthening the duration that the drug can be useful. But because this polymer is so widely used, many people have developed ...
Source: Mass Device - December 1, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Drug-Device Combinations Pharmaceuticals Research & Development Duke University Source Type: news

Drug delivery modification sidesteps allergic responses
Biomedical engineers have reconfigured a popular drug-delivery technology to evade immune responses that have halted some clinical trials. Polyethylene glycol, commonly known as PEG, is a polymer commonly found in commercial products from toothpaste to cosmetics, and also in pharmaceuticals. PEG is used as a thickener, solvent, softener and moisture-carrier, but it can also be attached to active drugs in the bloodstream to slow the body's clearing of them, greatly lengthening the duration of their effects. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 30, 2016 Category: Science Source Type: news

Drug delivery modification sidesteps allergic responses
(Duke University) Duke has developed an altered version of the polyethylene glycol (PEG) polymer used to ferry drugs in the bloodstream that seems to evade PEG antibodies already present in humans due to its common use in consumer goods. The new technology shows excellent efficacy as a drug delivery vehicle, controlling glucose levels in diabetic mice for up to four days when used with a drug that would otherwise work for only six hours. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 30, 2016 Category: Global & Universal Source Type: news

Severe Hyponatremic Encephalopathy following Bowel Prep for Colonoscopy
CONCLUSION This case highlights the need for physicians to be aware of the potential electrolyte disturbances that can occur in susceptible individuals during bowel prep for a colonoscopy. Any patient presenting with acute altered mental status in this setting should receive prompt electrolyte measurements and treatment of hyponatremia with hypertonic saline to help minimize associated morbidity. REFERENCES Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342 (21):1581-1589. Frizelle FA, Colls BM. Hyponatremia and seizures after bowel preparation: report of three cases. Dis Colon Rectum. 2005;48(2):393-396. doi:...
Source: EPMonthly.com - November 25, 2016 Category: Emergency Medicine Authors: Matt McGahen Tags: Uncategorized Source Type: news

Deals this week: Merck, Zydus Cadila Healthcare Limited, AbbVie
Merck& Co and JenKem Technology have entered a distribution agreement to make Jenkem ’s polyethylene glycol (PEG) products available for biomedical applications. (Source: Drug Development Technology)
Source: Drug Development Technology - September 22, 2016 Category: Pharmaceuticals Source Type: news

Are Head Transplants Possible... and Ethical?
During a cold, dreary summer in Switzerland 200 years ago, English author Mary Shelley sat down to write her novel "Frankenstein." The story -- and subsequent adaptations for the screen -- has gripped our imaginations ever since. While reanimating the dead remains a scientific impossibility, scientists are pushing the boundaries of modern medicine closer and closer to Shelley's vision. As they do, the public's uneasiness about the ethical limits of medicine has been stoked. Take, for example, the announcement last year by Italian neuroscientist Dr. Sergio Canavero that he plans to perform the first human head...
Source: Healthy Living - The Huffington Post - September 19, 2016 Category: Consumer Health News Source Type: news

MiraLAX (Polyethylene Glycol 3350 - OTC) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 13, 2016 Category: Drugs & Pharmacology Source Type: news

What Causes Hyperphosphatemia?
Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdo...
Source: PediatricEducation.org - September 12, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Active Prep vs Clear Fluids Before Capsule Endoscopy Active Prep vs Clear Fluids Before Capsule Endoscopy
A clear-fluid diet is just as effective as polyethylene glycol (PEG) or sodium picosulfate plus magnesium (P/MC) as preparation for video capsule endoscopy, and the clear-fluids regimen is better tolerated, researchers say.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - August 2, 2016 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Rant: ultrasound visualization of pills in the stomach will never make sense
Konstantin Shevtsov/shutterstock.com 2 out of 5 stars Accuracy of Trans-Abdominal Ultrasound in a Simulated Massive Acute Overdose. Sullivan S et al.  Am J Emerg Med 2016 Apr 23 [Epub ahead of print] Abstract As soon as emergency portable bedside ultrasound became feasible approximately three decades ago, toxicologists wondered if it would be a useful modality for visualizing pills in the stomach of overdose patients. The answer, clearly, is no it would not. This misguided paper illustrates why. This randomized study had a study group (N=10) and a control group (N=10) ingest 50 enteric-coated placebo capsules plu...
Source: The Poison Review - May 25, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical activated charcoal acute ingestion gastric lavage sonography ultrasound whole bowel irrigation Source Type: news

Mircera (Methoxy Polyethylene glycol-epoetin beta) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 9, 2016 Category: Drugs & Pharmacology Source Type: news

Poisoning by polyethylene glycol , an adjuvant for insecticides - Revanna KG, Chandran S, Saiprasad -, Kasaragod A.
BACKGROUND: Accidental poisoning in children with surfactant used as an agriculture adjuvant is uncommon. CASE CHARACTERISTICS: A 7-month-old girl presented with severe respiratory distress 48 hours following ingestion of surfactant, and required intubatio... (Source: SafetyLit)
Source: SafetyLit - February 19, 2016 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

Hypoxia-Responsive Copolymer for siRNA Delivery
A wide variety of nanomedicine has been designed for cancer therapy. Herein, we describe the synthesis and evaluation of a hypoxia-responsive copolymer for siRNA delivery (Perche et al., Angew Chem Int Ed Engl 53:3362–3366, 2014). The synthesis is achieved using established coupling chemistry and accessible purification procedures. A polyelectrolyte-lipid conjugate (polyethyleneimine 1.8 kDa-dioleyl-phosphatidylinositol, PEI-PE) and polyethylene glycol 2000 (PEG) were assembled via the hypoxia-sensitive azobenzene (Azo) unit to obtain the PEG-Azo-PEI-DOPE copolymer. This copolymer can condense siRNA and shows hypoxia...
Source: Springer protocols feed by Imaging/Radiology - October 11, 2015 Category: Radiology Source Type: news

MicroRNA Imaging in Combination with Diagnostic Ultrasound and Bubble Liposomes for MicroRNA Delivery
MicroRNA (miRNA) is expected to play an important role in the diagnosis and therapy of various diseases. In miRNA therapy, the development of delivery tools to the target site is considered to be essential. By using a delivery tool possessing imaging ability, miRNA colocalized with the carrier could be visualized after administration. We prepared polyethylene glycol (PEG)-modified liposomes containing echo-contrast gas, “Bubble liposomes” (BLs), and confirmed that BLs containing cationic lipid were capable of loading miRNA. Furthermore, we also achieved the imaging and delivery of systemically injected miRNA to...
Source: Springer protocols feed by Imaging/Radiology - October 11, 2015 Category: Radiology Source Type: news

Low-Cost Peptide Microarrays for Mapping Continuous Antibody Epitopes
With the increasing need for understanding antibody specificity in antibody and vaccine research, pepscan assays provide a rapid method for mapping and profiling antibody responses to continuous epitopes. We have developed a relatively low-cost method to generate peptide microarray slides for studying antibody binding. Using a setup of an IntavisAG MultiPep RS peptide synthesizer, a Digilab MicroGrid II 600 microarray printer robot, and an InnoScan 1100 AL scanner, the method allows the interrogation of up to 1536 overlapping, alanine-scanning, and mutant peptides derived from the target antigens. Each peptide is tagged wi...
Source: Springer protocols feed by Immunology - September 29, 2015 Category: Allergy & Immunology Source Type: news

polyethylene glycol 3350 (Miralax, Glycolax)
Title: polyethylene glycol 3350 (Miralax, Glycolax)Category: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 9/18/2015 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - September 18, 2015 Category: Nutrition Source Type: news

Management of body packers
This article from Hillingdon Hospital in London — located a mere 4 miles from Heathrow airport — was intended to evaluate the facility’s existing protocol for managing body packers. Although some details of their protocol are not justified or even well-described, in general they align with the trend towards conservative treatment of asymptomatic patients, with observation bowel cleansing agents — they used Picolax (sodium picosulfate with magnesium citrate) or Klean-Prep (polyethylene glycol.) Surgery was reserved for patients showing signs of toxicity from cocaine or heroin, or gastrointestinal obs...
Source: The Poison Review - August 25, 2015 Category: Toxicology Authors: Leon Tags: Medical body packers cocaine Hillingdon Hospital management mules Source Type: news

Malic acid encourages sweet cherry cracking
(American Society for Horticultural Science) Water uptake and fruit cracking in sweet cherries was observed following incubation in polyethylene glycol 6000, real sweet cherry juice extracted from the same batch of fruit, or in artificial juice. A dramatic increase in cracking was observed when sweet cherry fruit was in direct contact with the expressed juice of sweet cherries. The research clearly identified malic acid as the major crack-promoting component in sweet cherry juice. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 29, 2015 Category: Biology Source Type: news

New agent targets ovarian, prostate cancer
A protein linked to polyethylene glycol chains can attach itself to ovarian (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 8, 2015 Category: Radiology Source Type: news

Roche enters into exclusive license agreement with Galenica for the commercialisation of Mircera in the United States
Roche announced today that it has entered into an exclusive licence agreement with Galenica for the commercialisation of Roche's drug Mircera (methoxy polyethylene glycol-epoetin beta) in the US and Puerto Rico. Mircera is a prescription medicine used to treat symptomatic anaemia associated with chronic kidney disease (CKD) in adult patients and represents an ideal complement to the existing product portfolio of Galenica for patients with CKD and iron deficiency. (Source: Roche Investor Update)
Source: Roche Investor Update - May 28, 2015 Category: Pharmaceuticals Source Type: news

Understanding Miralax: The parents’ guide on how to approach constipation
Increase water intake and exercise, adopt and maintain a fiber-rich diet and avoid foods that bind you. These are common ways to find relief from constipation. But sometimes a child needs more to keep the digestive “engines,” (or bowels) moving. To ease the discomfort of chronic childhood constipation, pediatricians often prescribe an over-the-counter laxative called Miralax, the brand name for the generic drug polyethylene glycol 3350. The odorless, tasteless powder is typically mixed with 8 ounces of water or other liquid-of-choice and prescribed to children for use once or twice daily. Common side ...
Source: Thrive, Children's Hospital Boston - March 17, 2015 Category: Pediatrics Authors: Maureen McCarthy Tags: Diseases & conditions Source Type: news

Injectable Nanoparticles Could Protect Injuries from Oxidative Stress
Scientists at Rice University, Baylor College of Medicine and the University of Texas Health Science Center at Houston (UTHealth) Medical School designed methods to validate their 2012 discovery that combined polyethylene glycol-hydrophilic carbon clusters - known as PEG-HCCs - could quickly stem the process of overoxidation that can cause damage in the minutes and hours after an injury. (Source: Disabled World)
Source: Disabled World - February 11, 2015 Category: Disability Tags: Nanotechnology Nanomedicine Source Type: news

Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles
Targeted delivery of therapeutics to the mitochondria of cells without alteration of drug properties can be a vital technique in the treatment of a variety of mitochondrial-dysfunction-related diseases. Herein, we describe a detailed protocol for synthesis and characterization of a functionalized polymer to build mitochondria-targeted nanoparticles (NPs). The block polymer was decorated with a lipophilic triphenylphosphonium (TPP) cation for mitochondrial trafficking of payload-loaded polymeric NPs. TPP-based lipophilic cations have the ability to cross the mitochondrial membrane. A mitochondria-targeted block copolymer po...
Source: Springer protocols feed by Pharmacology/Toxicology - February 5, 2015 Category: Drugs & Pharmacology Source Type: news

Whole bowel irrigation? Don’t just do something, stand there!
3.5 out of 5 stars Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Thanacoody R et al. Clin Toxicol 2015 Jan;53:5-12. Abstract In 1997 the American Academy of Clinical Toxicology (AACT) and the Euroopean Association of Poisons Centre and Clinical Toxicologists (EAPCCT) published a position paper regarding the use of whole bowel irrigation (WBI) for gastrointestinal decontamination in the poisoned patient. The key conclusions were that no evidence existed showing that WBI improved clinical outcome, and that it should not be used routinely but “may be consid...
Source: The Poison Review - January 13, 2015 Category: Toxicology Authors: Leon Tags: Medical gastrointestinal decontamination overdose poisoning polyethylene glycol position paper whole bowel irrigation Source Type: news

FDA Questioning Miralax Use in Kids (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM At the request of the FDA, scientists are studying how children metabolize the active ingredient in the adult laxative polyethylene glycol … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 7, 2015 Category: Primary Care Source Type: news

Polyethylene Glycol (PEG) and Electrolytes
Title: Polyethylene Glycol (PEG) and ElectrolytesCategory: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 11/19/2014 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - November 19, 2014 Category: Nutrition Source Type: news

A phase change storage material that may be used in the fire resistance of building structure - Wang P, Li N, Zhao C, Wu L, Han G.
This study prepared polyethylene glycol/silicon dioxide composite, a kind of form-stable phase change material. The composites can be made into mortar which is able to adhere to the surface of building structure and absorb the fire heat. This paper aims to... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 15, 2014 Category: Global & Universal Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Hydrolytically Degradable Polyethylene Glycol (PEG) Hydrogel: Synthesis, Gel Formation, and Characterization
Degradable tight-mesh hydrogel scaffolds are a promising cell carrier for neural transplantation because they can match the stiffness of the native tissue, decrease immunogenicity of the transplant, and degrade over time as the new tissue forms. Here we describe the synthesis and gel formation of a hydrolytically degradable polyethylene glycol (PEG) hydrogel, where the mild gelation conditions allow for cell encapsulation prior to gel formation. We also describe how to measure swelling ratio and mass loss of the hydrogel over time in order to assess hydrogel degradation. (Source: Springer protocols feed by Neuroscience)
Source: Springer protocols feed by Neuroscience - November 4, 2014 Category: Neuroscience Source Type: news

Mircera (Methoxy Polyethylene glycol-epoetin beta) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 16, 2014 Category: Drugs & Pharmacology Source Type: news

polyethylene glycol 3350 (Miralax, GoLytely)
Title: polyethylene glycol 3350 (Miralax, GoLytely)Category: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 10/2/2014 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - October 2, 2014 Category: Drugs & Pharmacology Source Type: news

polyethylene glycol 3350 (Miralax, GoLytely)
Title: polyethylene glycol 3350 (Miralax, GoLytely)Category: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 10/2/2014 12:00:00 AM (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - October 2, 2014 Category: Gastroenterology Source Type: news

What Causes Abdominal Distention?
Discussion Constipation generally is defined as infrequent or painful defecation. It often is due to passing large hard stool infrequently which causes painful defecation and then withholding behaviors. As stool withholding continues, the rectum dilates and gradually accommodates with the normal defecation urge disappearing. Chronic rectal distension results in both loss of rectal sensitivity, and loss of urge to defecate, which can lead to encopresis. Abdominal distention because of stool retention occurs frequently. Treatment includes colonic evacuation, establishing regular bowel habits, eating a balanced diet with diet...
Source: PediatricEducation.org - July 21, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Proteomic Approaches to Identify Cold-Regulated Plasma Membrane Proteins
Plasma membrane is the primary determinant of freezing tolerance in plants because of its central role in freeze–thaw cycle. Changes in the plasma membrane proteins have been one of the major research areas in plant cold acclimation. To obtain comprehensive profiles of the plasma membrane proteomes and their changes during the cold acclimation process, a plasma membrane purification method using a dextran–polyethylene glycol two polymer system and a mass spectrometry-based shotgun proteomics method using nano-LC-MS/MS for the plasma membrane proteins are described. The proteomic results obtained are further app...
Source: Springer protocols feed by Plant Sciences - May 27, 2014 Category: Biology Source Type: news

Good quick review of bupropion toxicity, but . . . whole bowel irrigation? Seriously??
2.5 out of 5 stars Bupropion Abuse and Overdose. Stall N et al. CMAJ 2014 Apr 28 [Epub ahead of print] No abstract available online This one-page précis is part of CMAJ‘s “Five Things To Know About _______” series. The key points include: Bupropion blocks reuptake of dopamine and norepinephrine, and also blocks the action of acetylcholine at nicotinic receptors. Burpropion is abused recreationally for its mild cocaine-like “high.” Routes of bupropion abuse include snorting, ingestion, and intravenous injection. Brupropion lowers the threshold for seizures, which may be d...
Source: The Poison Review - May 9, 2014 Category: Toxicology Authors: Leon Tags: Medical abuse bupropion overdose seizures Source Type: news

Nicotiana tabacum : PEG-Mediated Plastid Transformation
Stable plastid transformation in Nicotiana tabacum has been achieved by using two different methods, the biolistic method, using a particle gun, and the polyethylene glycol (PEG)-mediated transformation. PEG-mediated plastid transformation involves the treatment of isolated protoplasts (plant cells without cell wall) with PEG in the presence of DNA. We have previously shown that in Nicotiana tabacum both methods are equally efficient. The PEG-mediated transformation efficiencies range between 20 and 50 plastid transformants per experiment (106 viable treated protoplasts). One advantage of the PEG method is that no expensiv...
Source: Springer protocols feed by Plant Sciences - March 6, 2014 Category: Biology Source Type: news

Plastid Transformation in Lettuce (Lactuca sativa L.) by Polyethylene Glycol Treatment of Protoplasts
A detailed protocol for PEG-mediated plastid transformation of Lactuca sativa cv. Flora, using leaf protoplasts, is described. Successful plastid transformation using protoplasts requires a large number of viable cells, high plating densities, and an efficient regeneration system. Transformation was achieved using a vector that targets genes to the trnI/trnA intergenic region of the lettuce plastid genome. The aadA gene, encoding an adenylyltransferase enzyme that confers spectinomycin resistance, was used as a selectable marker. With the current method, the expected transformation frequency is 1–2 spectinomycin-resi...
Source: Springer protocols feed by Plant Sciences - March 6, 2014 Category: Biology Source Type: news

Consumer Information on: ReSure® Sealant - P130004
ReSure Sealant prevents leakage from a cut (incision) in the cornea. It is made of two solutions, a polyethylene glycol solution and a trilysine amine solution. It is applied to a corneal incision using an applicator. (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - January 15, 2014 Category: Medical Equipment Source Type: news

Pediatric leukemia patients benefit from less painful drug delivery
Children with acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful intramuscular injection for more than 40 years, research suggests.Researchers looked at the four-year, event-free survival and toxicity of E. coli L-asparaginase delivered via IV in its polyethylene glycol (PEG)-conjugated formulation or through IM injection in its native formulation. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 12, 2013 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Molecular Targeted Viral Nanoparticles as Tools for Imaging Cancer
Viral nanoparticles (VNPs) are a novel class of bionanomaterials that harness the natural biocompatibility of viruses for the development of therapeutics, vaccines, and imaging tools. The plant virus, cowpea mosaic virus (CPMV), has been successfully engineered to create novel cancer-targeted imaging agents by incorporating fluorescent dyes, polyethylene glycol (PEG) polymers, and targeting moieties. Using straightforward conjugation strategies, VNPs with high selectivity for cancer-specific molecular targets can be synthesized for in vivo imaging of tumors. Here we describe the synthesis and purification of CPMV-based VNP...
Source: Springer protocols feed by Biotechnology - November 20, 2013 Category: Biotechnology Source Type: news

NuLytely (Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 7, 2013 Category: Drugs & Pharmacology Source Type: news

GoLytely (Polyethylene Glycol 3350 and Electrolytes Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 4, 2013 Category: Drugs & Pharmacology Source Type: news