Links 10/24/2023
‘Superfog’ near New Orleans blamed for highway crashes that killed at least 7 Associated Press (furzy) California Moves Ahead of the FDA in Banning Common Candy Additives KFF Health News Nanocarriers study shows antibodies against polyethylene glycol in 83% of the German population PhysOrg (fk).…#neworleans #californiamovesahead #fda #physorg #studyclaims #davidl #empresselisabeth #anthonyl #maskswork #universitystudents (Source: Reuters: Health)
Source: Reuters: Health - October 24, 2023 Category: Consumer Health News Source Type: news
Wave of American teens are using laxatives as 'budget Ozempic' as part of TikTok trend - causing shortage of the stool-loosening drugs
Demand is beginning to outstrip supply for polyethylene glycol 3350, the generic name for laxatives in the US like Miralax and Glycolax. Laxatives may give the impression of weight-loss. (Source: the Mail online | Health)
Source: the Mail online | Health - September 11, 2023 Category: Consumer Health News Source Type: news
America is suffering a shortage of LAXATIVES due to surging demand - and recent work trend is partly to blame
Demand is beginning to outstrip supply for polyethylene glycol 3350, the generic name for laxatives like Miralax and Glycolax. An aging population in America is partly to blame. (Source: the Mail online | Health)
Source: the Mail online | Health - September 8, 2023 Category: Consumer Health News Source Type: news
Can ’ t You Just Do a Hydrogen Breath Test?
Discussion
Lactose is a sugar that is commonly found in dairy products. It is digested by the enzyme lactase mainly found on the brush border of the small bowel. Lactase production varies by age and genetics, with infants and young children having a generally higher amount than older children and adults, presumably as they have a more dairy-based diet. There is decreased production starting around 2-3 years of age (i.e. lactase non-persistence). Some people continue to produce lactase at the same levels as infants (i.e. lactase-persistence. “Lactase persistence (lactose tolerance) is seen predominantly in individuals...
Source: PediatricEducation.org - August 14, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
FDA Approves Suflave (polyethylene glycol 3350, sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride) Colonoscopy Preparation that Tastes Similar to a Sports Drink
BRAINTREE, Mass., June 22, 2023 /PRNewswire/ -- Sebela Pharmaceuticals today announced that the U.S. Food and Drug Administration (FDA) granted approval of Suflave™ (polyethylene glycol, sodium sulfate, potassium chloride, magnesium... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - June 22, 2023 Category: Drugs & Pharmacology Source Type: news
What Are Some High or Low FODMAPs Foods?
Discussion
FODMAPs is an acronym standing for fermentable oligosaccharides, disaccharides, monosaccharides and polyols. It is a diet strategy which has shown improvement for some adult patients with functional abdominal pain including some with irritable bowel syndrome. The evidence in pediatrics is murky and more well-designed studies are needed; however such studies are difficult to complete. In general, there are 3 phases to this dietary strategy:
Avoidance of all high FODMAP foods for 2-6 weeks. In some adult studies there has been improvement in 1 week. Especially in the pediatric age group, some people will only res...
Source: PediatricEducation.org - June 12, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage.
Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news
Mining polyethylene glycol-based thermosensitive hydrogel materials: preparation and flame retardant properties - Shao H, Wang Z, Jiang S, Zhang Y, Xi X, Wu Z.
A new type of efficient and anti-extinguishing materials to inhibit coal spontaneous combustion is required because of the current situation of the short activity cycle of existing anti-extinguishing technology. Now, polyethylene glycol (PEG) was used as a... (Source: SafetyLit)
Source: SafetyLit - February 28, 2023 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
What Causes Rectal Prolapse?
Discussion
Rectal prolapse is defined as a herniation of the rectum through the anal verge. In children it is also usually mucosal prolapse and not full thickness. Partial or mucosal prolapse usually is seen as radial folds occurring 1 – 2.5 cm from the anal verge. Full thickness will protrude more than 5 cm. It affects genders equally and occurs most commonly in children under age 4. This is due to vertical course and low position of the anus, looser supporting tissues and less muscular support. These children are more likely to have prolapse but are less likely to have it recur. After age 4 the rectum takes the adu...
Source: PediatricEducation.org - February 28, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Anaphylaxis Case After mRNA Vaccination Traced to Polyethylene Glycol Allergy Anaphylaxis Case After mRNA Vaccination Traced to Polyethylene Glycol Allergy
An undiagnosed polyethylene glycol allergy was at the root of at least one anaphylaxis case associated with an mRNA-based COVID-19 vaccine, a UK report suggests.Reuters Health Information (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - April 13, 2021 Category: Emergency Medicine Tags: Infectious Diseases News Source Type: news
New insights on cause of anaphylaxis following COVID-19 vaccination
(Wiley) On the first day of the UK campaign for COVID-19 vaccination, there were reports of two cases of anaphylaxis a severe, potentially life-threatening allergic reaction within minutes of administration of the Pfizer/BioNTech mRNA vaccine. Subsequently further cases of suspected anaphylaxis to the Pfizer vaccine were reported. A new report published in Clinical& Experimental Allergy reveals that an allergy to the ingredient polyethylene glycol (PEG) is a cause of anaphylaxis to the vaccine. However, this is in the context of millions of doses safely administered. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 7, 2021 Category: Infectious Diseases Source Type: news
Complications and hospital stay after endoscopic retrieval of drug baggies in body stuffers: an observational prospective study - Shabani M, Kefayati M, Hassanian-Moghaddam H, Zamani N, McDonald R.
Body stuffers routinely receive conservative treatment, i.e. administration of the laxative polyethylene glycol for the passage of ingested drug baggies and observation. Endoscopic baggie removal may offer a safe alternative that could result in shorter ho... (Source: SafetyLit)
Source: SafetyLit - March 15, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Nano-micelle packaging CRISPR/Cas9 components enables brain genome editing
(Innovation Center of NanoMedicine) The search of safe and efficient delivery methods of CRISPR/Cas9 is still ongoing. We fabricated nano-micelle co-loading Cas9 mRNA and gRNA in the core, and proved for the first time that RNA-based delivery of CRISPR/Cas9 induces genome editing in mouse brain parenchyma. This was possible because: first, co-loading gRNA with Cas9 mRNA protected gRNA from degradation, and second, polyethylene glycol-covered nano-micelle allowed better diffusion in brain tissue. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 10, 2021 Category: International Medicine & Public Health Source Type: news
BMJ Editorial: Vaccinating against covid-19 in people who report allergies, BMJ
Editorial notes polyethylene glycol (PEG 2000) in the Pfizer-BioNTech vaccine is a known potential allergen. Oxford-AstraZeneca vaccine does not contain PEG2000 but does have polysorbate 80 which may be cross-reactive therefore evaluation by an allergy specialist may be required. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 19, 2021 Category: Consumer Health News Source Type: news
Allergists offer reassurance regarding potential allergic reactions to COVID-19 vaccines
(Massachusetts General Hospital) Reports of possible allergic reactions to COVID-19 vaccines have raised public concern; however, allergists note that allergic reactions to vaccines are rare, and COVID-19 vaccine allergic reactions will have a similarly low rate of occurrence. Individuals with a history of anaphylaxis to an injectable drug or vaccine containing polyethylene glycol or polysorbate should speak with an allergist before getting vaccinated, but patients with severe allergies to foods, oral drugs, latex or venom can safely receive the COVID-19 vaccines. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 31, 2020 Category: International Medicine & Public Health Source Type: news
