Fight Aging! Newsletter, October 2nd 2017
This study featured two independent experiments. The first established the safety of administering a therapeutic gene delivery vector, BNP116, created from an inactivated virus over three months, into 48 pigs without heart failure through the coronary arteries via catheterization using echocardiography. The second experiment examined the efficacy of the treatment in 13 pigs with severe heart failure induced by mitral regurgitation. Six pigs received the gene and 7 received a saline solution. The researchers determined that the gene therapy was safe and significantly reversed heart failure by 25 percent in the left ventricle and by 20 percent in the left atrium. Heart failure often results in enlarged hearts, and the team found a 10 percent reduction of heart size in the affected animals. Heart failure in the cohort of pigs treated with saline worsened. The research team plans to study the same gene therapy in a human trial starting next year. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure Increased protein phosphatase-1 in heart failure (HF) induces molecular changes deleterious to the cardiac cell. Inhibiting protein phosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown to reverse cardiac dysfunction in a model of ischemic HF. This study sought to determine the therapeutic efficacy of a re-engineered adeno-associated viral vector carrying I-1c (BNP116.I-1c) in...
Publication date: Available online 17 September 2020Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Jinhua Wang, Guili Lian, Li Luo, Tingjun Wang, Changsheng Xu, Huajun Wang, Liangdi Xie
CONCLUSIONS: Animal-encounter fatalities, analyzed by UCD alone, may be underreported. An initiating animal injury, complicated by comorbidities and fatality, may obscure the causal chain, resulting in misreporting UCD. Ongoing training for medical certifiers is recommended, highlighting accurate identification of UCD and contributing causes in the causal chain of death. PMID: 32933400 [PubMed - as supplied by publisher]
CONCLUSION: Oral manifestations of SS, particularly mouth ulcers or sores, trouble speaking, and dysphagia, were strongly associated with worse quality of life. Further study and targeted treatment of these oral manifestations provides the opportunity to improve quality of life in patients with SS. PMID: 32934136 [PubMed - as supplied by publisher]
CONCLUSION: In a multicenter cohort of patients with JIA starting a biologic, one-quarter switched to a second biologic, and the time to switching decreased in recent years. Additional studies should evaluate the outcomes and optimal timing of switching and preferred sequence of biologic use. PMID: 32934124 [PubMed - as supplied by publisher]
CONCLUSION: This exercise confirmed good reliability of HR-pQCT erosion measurements and their ability to detect change over time. PMID: 32934121 [PubMed - as supplied by publisher]
CONCLUSION: The existing Alberta health care system for RA is suboptimal, indicating barriers to accessing specialty care and treatment. The results inform quality improvement initiatives required within the province to meet national standards of care. PMID: 32934120 [PubMed - as supplied by publisher]
PET/MRI helps clinicians stage cancer treatment as well as PET/CT -- and finds...Read more on AuntMinnie.comRelated Reading: PET/MRI ups lesion detection by 15% for some cancers SNMMI 2020: PET/MRI finds location of chronic pain in patients SNMMI 2020: PET/MRI combo tracks osteoarthritis progression PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse
Authors: McGlone PJ, Li LT, Bokshan SL, O'Donnell R, Owens BD Abstract BACKGROUND: Rotator cuff repair (RCR) is a common orthopedic procedure frequently performed in the outpatient setting. Malnutrition, as assessed by preoperative serum albumin
Publication date: Available online 17 September 2020Source: Journal of Arthroscopy and Joint SurgeryAuthor(s): Manit Arora, Sanjay Kumar Bhadada
Psychosocial health may influence the outcomes after total knee arthroplasty (TKA). We investigated the hypothesis that multimodal therapy influences the quality of life and function in patients diagnosed with osteoarthritis of the knee joint. Secondly, in patients who then proceed to have TKA post-multimodal therapy, does the response to the multimodal therapy influence the overall functional outcome of surgery? Patients diagnosed with osteoarthritis of the knee were enrolled in the study and prospectively followed-up. A total of 526 patients were enrolled and available for the study. All participants were enrolled for 12...
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