Drug Repurposing Study Could Identify New Mesothelioma Treatments
The next breakthrough in the treatment of malignant mesothelioma may be quietly underway. An international research team based at Temple University in Philadelphia recently identified four drug compounds – already being used safely for noncancerous conditions – that have shown impressive potential for treating mesothelioma. They were part of a novel drug repurposing project aimed at uncovering much-needed options for mesothelioma patients. “Mesothelioma has shown resistance to all current treatments, including immunotherapy. Novel combinations are badly needed now,” Dr. Antonio Giordano, director of Sbarro He...
Source: Asbestos and Mesothelioma News - July 6, 2022 Category: Environmental Health Authors: Fran Mannino Tags: Clinical Trials/Research/Emerging Treatments Mesothelioma Source Type: news

Outcomes of CMS-mandated fluid administration among fluid-overloaded patients with sepsis: A systematic review and meta-analysis
The outcomes of large-volume IVF administration to septic shock patients with comorbid congestive heart failure (CHF) and/or end-stage renal disease (ESRD) are uncertain and widely debated in the existing literature. Despite this uncertainty, CMS continues to recommend that 30 ml/kg of an intravenous crystalloid solution be administered to patients in septic shock starting within 3 h of presentation. We performed a systematic review and meta-analysis to assess the relationship between adherence to this guideline and outcomes among patients whose underlying comorbidities present a risk of fluid overload. (Source: Current Aw...
Source: Current Awareness Service for Health (CASH) - June 10, 2022 Category: Consumer Health News Source Type: news

How Healthcare Fails the Homeless How Healthcare Fails the Homeless
Many of the things that kill the homeless are the same that sicken and kill others -- liver disease, congestive heart failure, substance abuse. But the system isn ' t equipped to handle the problems.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 30, 2022 Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

Slash health: 'I was fortunate. I didn’t die' - guitarist on drug-induced heart disease
LEGENDARY guitarist Slash, born Saul Hudson, made his name as part of hard rock band Guns N' Roses. Having reached the height of his fame in the 1990s, Slash struggled with both drugs and alcohol addiction, a habit that would severely damage his long-term health as back in 2001, he was diagnosed with cardiomyopathy, a form of congestive heart failure. (Source: Daily Express - Health)
Source: Daily Express - Health - April 22, 2022 Category: Consumer Health News Source Type: news

Congestive Heart Failure
kls117@duke.eduWed, 04/06/2022 - 16:22 Treatment PageCongestive Heart Failure ProvidersRicha Agarwal, MDAdam D. DeVore, MD, MHSG. Michael Felker, MD, MHSMarat Fudim, MD, MHSStephen J. Greene, MDAdrian F. Hernandez, MD, MHSChristopher L. Holley, MD, PhDRavi Karra, MD, MHSJason N. Katz, MD, MHSMichel G. Khouri, MDRobert J. Mentz, MDKishan S. Parikh, MDChetan B. Patel, MDPaul B. Rosenberg, MDStuart D. Russell, MDMichael A. Blazing, MDNathan M. Allen, AGPNP-CDennis M. Abraham, MDMargaret "Midge" Bowers, DNP, FNP-BCCarolyn L. Lekavich, PhD, ANP-CKevin D. Cox, FNP-BCStephanie G. Barnes, MSN, AGPCNP-BC, PCCNKhyati Baxi, MDG...
Source: dukehealth.org: Health Tips - April 6, 2022 Category: Primary Care Authors: kls117 at duke.edu Source Type: news

What Are Potential Physical Examination Findings for Patients with Atrioventricular Canal Defects?
Discussion Atrioventricular canal defects (AVCD) are a heterogeneous range of congenital heart defects (CHD) arising from malformations of intracardiac septal development. Essentially the location where the 4 corners of the 2 atria and 2 ventricula meet is abnormally formed. There is partial or complete fusion of the mitral and tricuspid valves along with atrial (ASD) and ventricular septal defects (VSD). Fusion of the endocardial cushions occurs around 4-5 weeks gestation. The anatomy for an individual is bespoke as the variations of the valve leaflets, chordal attachments and variations in ASD and VSD are numerous. This ...
Source: PediatricEducation.org - March 21, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

The Amazing Johnathan Dead at 63 from Congestive Heart Failure
Comedian The Amazing Johnathan is dead at the age of 63 after battling heart issues for years. #congestiveheartfailure #amazingjohnathandead #comedian #amazingjohnathan (Source: Reuters: Health)
Source: Reuters: Health - February 23, 2022 Category: Consumer Health News Source Type: news

New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Data at ASCO GU Demonstrate Longstanding Leadership in Prostate Cancer and Commitment to Advancing Potential New Therapeutic Options for Genitourinary Cancers
Raritan, NJ, Feb. 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that 17 presentations will be featured at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place in San Francisco and virtually from February 17-19. Building on its long-term leadership in prostate cancer, Janssen is committed to advancing innovative treatments and transforming patient experiences, while focusing on research that may drive better outcomes for people across the genitourinary cancer spectrum. Data to be presented include Phase 3 results for the selective ...
Source: Johnson and Johnson - February 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Cardiovascular Disease in Pregnancy
Cardiovascular disease remains a major contributor to rising maternal morbidity and mortality. Both the pregnant woman and fetus are exposed to many potential complications as a result of the physiologic changes of pregnancy. These changes can exacerbate existing cardiac disease, as well as lead to the development of de novo issues during gestation, delivery, and the postnatal period. For women with preexisting cardiac disease, including congenital malformations, valvular disease, coronary artery disease, and aortopathies, it is crucial that they receive multidisciplinary evaluation, counseling, and optimization before con...
Source: NeoReviews recent issues - November 1, 2021 Category: Pediatrics Source Type: news

What is Refeeding Syndrome?
Discussion Anorexia nervosa is an eating disorder with an intense fear of being overweight (i.e. distorted body image), and self-starvation and excessive weight loss. It is more common in women (1.2%) than men (0.2%) but can be seen in both genders. Risk factors include high-intelligence, perfectionism/inflexibility, anxiety, activities where thinner body types are expected (e.g. dancer, diver, gymnast, long-distance runner, volleyball player, etc.) Other eating disorders include bulimia nervosa (i.e. cycles of binge eating and then purging), binge eating disorder (i.e. purging), orthorexia (i.e. obsessions with healthful ...
Source: PediatricEducation.org - October 25, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

ERLEADA ® (apalutamide) Oral Presentations Demonstrate Importance of Prostate Specific Antigen (PSA) as Key Efficacy Indicator and Show Strong Patient Adherence Rates
September 11, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data demonstrating robust prostate-specific antigen (PSA) response and strong adherence rates in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) treated with ERLEADA® (apalutamide) in the real-world clinical setting. The strong PSA response was also seen in a separate post-hoc analysis that showed a correlation between rapid and deep PSA response and prolonged survival in both metastatic castration-sensitive prostate cancer (mCSPC) and nmCRPC. The post-hoc analysis also suppor...
Source: Johnson and Johnson - September 12, 2021 Category: Pharmaceuticals Source Type: news

Janssen Demonstrates Commitment to Advancing Science and Innovation in the Treatment of Solid Tumors at ESMO Annual Congress
September 8, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than ten data presentations from its lung cancer, bladder cancer and prostate cancer portfolio and pipeline will be featured during the European Society for Medical Oncology (ESMO) Annual Congress 2021 virtual meeting, September 16–21. Further details about these data and the science Janssen is advancing will be made available throughout ESMO via the Janssen Oncology Virtual Newsroom.“With a diverse oncology portfolio and pipeline spanning bladder cancer, lung cancer and prostate cancer, Janssen...
Source: Johnson and Johnson - September 8, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Striving to Deliver Better Outcomes: Janssen to Showcase Commitment to Advancing Science for Genitourinary Cancers at AUA 2021
August 31, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today multiple company-sponsored presentations in prostate and bladder cancers will be highlighted at the virtual 2021 American Urological Association Annual Meeting (AUA 2021), September 10-13. “Janssen maintains a strong commitment to advancing innovation and new therapeutic options for patients with genitourinary malignancies. As the treatment of genitourinary cancers becomes more complex, we continue to work with urologists and their teams to improve outcomes for patients across the continuum of disease,” sai...
Source: Johnson and Johnson - August 31, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Sleep Apnea Doubles Odds for Sudden Death
New research shows sleep apnea may also increase the risk for high blood pressure, coronary artery disease and congestive heart failure. (Source: WebMD Health)
Source: WebMD Health - August 3, 2021 Category: Consumer Health News Source Type: news