Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
« Back to Top
Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells acts to maintain a more dysfunctional, inflamed metabolism. This is well known by now, and numerous biotech companies in the first wave of development of senolytic treatments to selectively destroy senescent cells are in varying stages of preclinical and clinical development. Meanwhile, the off-label use of dasatinib and quercetin, a low-cost senolytic therapy that is neither developed nor promoted by any company, continues to look promising based on the slow progression of clinical trials.
Cellular senescence is implicated in ageing and associated with a broad spectrum of age-related diseases. Importantly, a cell can initiate the senescence program irrespective of the organism's age. Various stress signals, including those defined as ageing hallmarks and alterations leading to cancer development, oncogene activation, or loss of cancer-suppressive f...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More News: Alzheimer's | Amnesia | Biotechnology | Bipolar | Bolivia Health | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Cardiovascular | Clinical Trials | Covid Vaccine | COVID-19 | Dementia | Dengue Fever | Diabetes | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Education | Endocrinology | Environmental Health | Epidemics | Epidemiology | Flu Pandemic | Gastroschisis Repair | Gene Therapy | Genetics | Greece Health | Heart | Heart Attack | Heart Disease | Heart Failure | Heart Transplant | Hypertension | Immunotherapy | Influenza | Influenza Vaccine | Ischemic Stroke | Kidney Transplant | Learning | Liver | Liver Transplant | Lung Transplant | Mania | Men | Mitochondrial Disease | Molecular Biology | Multiple Sclerosis | Neurology | Neuroscience | New Zealand Health | Nutrition | Obesity | Obsessive Compulsive Disorder | Pandemics | Pathology | Penicillin | Peripheral Vascular Disease (PVD) | Research | Science | Scotland Health | Sports Medicine | Statistics | Stem Cell Therapy | Stem Cells | Stroke | Study | Training | Universities & Medical Training | Urology & Nephrology | Vaccines | Veterinary Vaccinations | Warnings | Zika Virus