Fight Aging! Newsletter, January 8th 2024

This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction. Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group. The SG function and structural tissue remodeling by the saPRP were investigated with naturally aged mice. The mice were divided into three groups: 3 months old (3 M), 22 months old (22 M), and 22 months old treated with saPRP (22 M + saPRP). Salivary flow rate and lag time were significantly improved in 22 M + saPRP group compared to 22 M group. The histologic examinations showed the significant proliferation of acinar cells in the SG of the 22 M + saPRP group. A decrease of senescence, apoptosis, and inflammation was observed by western blot in the 22 M + saPRP group. « Back to Top Methionine Restriction Extends Life in Flies https://www.fightaging.org/archives/2024/01/methionine-restriction-extends-life-in-flies/ A sizable fraction of the benefits to health and life span resulting from the practice of calor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs