Fight Aging! Newsletter, December 12th 2022

In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging. Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/ Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death or destruction by immune cells. When senescent cells linger, as is increasingly the case with age, they contribute to degenerative aging via their pro-growth, pro-inflammatory signaling, disruptive of tissue structure and function. Researchers have suggested that non-dividing, post-mitotic cells such as neurons can also exhibit a form of senescence, and here evidence is provided for this to be the case. Senescence in supporting cells in the brain, such as microglia and astrocytes, is known to contribute to neurodegeneration. If some neurons are also senescent, producing similar harmful signaling, then these cells will also contribute to the aging of the brain. As cells age, they can undergo cellular senescence, which contributes to tissue dysfunction and age-related disorders. Senescence is also thought to play a role in cellular stress, molecular ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs