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Understanding vitamin D trends in children with non-alcoholic fatty liver disease
(University of Leeds) New research charts vitamin D levels and variations in genes that determine vitamin D status in UK children diagnosed with non-alcoholic fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2018 Category: International Medicine & Public Health Source Type: news

IRE1{alpha} prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. An impaired UPR is associated with hepatic steatosis and nonalcoholic fatty liver disease (NAFLD), which is caused by lipid accumulation in the liver. We found that IRE1α was critical to maintaining lipid homeostasis in the liver by repressing the biogenesis of microRNAs (miRNAs) that regulate lipid mobilization. In mice fed normal chow, the endoribonuclease function of IRE1α processed a subse...
Source: Signal Transduction Knowledge Environment - May 15, 2018 Category: Science Authors: Wang, J.-M., Qiu, Y., Yang, Z., Kim, H., Qian, Q., Sun, Q., Zhang, C., Yin, L., Fang, D., Back, S. H., Kaufman, R. J., Yang, L., Zhang, K. Tags: STKE Research Articles Source Type: news

Gut check: Metabolites shed by intestinal microbiota keep inflammation at bay
(Tufts University) Researchers have elucidated a mechanism by which 'good' bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study, now available in the journal Cell Reports, identified two key metabolites produced by the bacteria in mice that modulate inflammation in the host and could ultimately reduce the severity of non-alcoholic fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 4, 2018 Category: International Medicine & Public Health Source Type: news

Index of NASH for Diagnosis of Steatohepatitis in NAFLD Index of NASH for Diagnosis of Steatohepatitis in NAFLD
This study examined the feasibility of a new non-invasive algorithm for the prediction of NASH--the ION index. Is it useful across different populations of patients with NAFLD?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 3, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Dietary Improvements May Prevent NAFLD Dietary Improvements May Prevent NAFLD
People who make an effort to improve their diet may have a lower risk of non-alcoholic fatty liver disease (NAFDL) than individuals who stick to unhealthy eating habits, a U.S. study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 30, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Eating a lot of processed meat increases your risk of non-alcoholic fatty liver disease and insulin resistance
(Natural News) Researchers have found another reason why eating a lot of processed meat is bad: It increases the risk of non-alcoholic fatty liver disease (NAFLD) and insulin resistance, according to a study published in the Journal of Hepatology. These results add to the increasing amount of evidence on the harmful effects of eating red... (Source: NaturalNews.com)
Source: NaturalNews.com - April 30, 2018 Category: Consumer Health News Source Type: news

BMI Trajectories in Young Adults Predict NAFLD in Middle Age BMI Trajectories in Young Adults Predict NAFLD in Middle Age
Might strategies for weight maintenance through young adulthood be more successful at preventing NAFLD than weight loss later in life?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 26, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Poverty Harms Patients With Diabetes, Fatty Liver Poverty Harms Patients With Diabetes, Fatty Liver
When patients with diabetes and nonalcoholic fatty liver disease cannot consistently afford a healthy diet, the risk for advanced hepatic fibrosis is elevated, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 17, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Gains from online lifestyle intervention similar to group program ’s for liver disease patients
In a cohort of patients with non-alcoholic fatty liver disease (NAFLD), an online lifestyle modification-focused intervention was similarly effective to a group-based program in achieving weight loss and liver enzyme normalization, according to data from an Italian study recently presented at The International Liver Congress in Paris. (Source: mobihealthnews)
Source: mobihealthnews - April 16, 2018 Category: Information Technology Source Type: news

Costs Balloon after Cirrhosis Diagnosis for NAFLD/NASH (CME/CE)
(MedPage Today) -- Experts say study emphasizes importance of identifying patients early (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 16, 2018 Category: Primary Care Source Type: news

' Well Done' Red Meat Linked to Liver Disease, Insulin Resistance'Well Done' Red Meat Linked to Liver Disease, Insulin Resistance
People who eat lots of processed and red meat are at increased risk of developing non-alcoholic fatty liver disease and insulin resistance, especially if they like their steak well done, an Israeli study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 13, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Eating red meat boosts the risk of deadly liver disease
Israeli scientists have found the risk of non-alcoholic fatty liver disease is highest for those who enjoy their steak 'well done'. The conclusion was made based on a study of 789 adults. (Source: the Mail online | Health)
Source: the Mail online | Health - April 13, 2018 Category: Consumer Health News Source Type: news

Germany: compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
(European Association for the Study of the Liver) Compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
(European Association for the Study of the Liver) A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

Empagliflozin Trims Liver Fat in Patients With T2D and NAFLD Empagliflozin Trims Liver Fat in Patients With T2D and NAFLD
Dr Kuchay discusses his findings from the E-LIFT study.Endocrine Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 9, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Commentary Source Type: news

PCOS linked to increased liver disease risk
According to a study, published inPLOS Medicine, women with PCOS have double the risk of developing nonalcoholic fatty liver disease.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 6, 2018 Category: Endocrinology Source Type: news

Liver Health Takes a Hit in Kids as Young as 8 Years Old Liver Health Takes a Hit in Kids as Young as 8 Years Old
Children who are obese or overweight in early childhood are at increased risk of developing signs of nonalcoholic fatty liver disease as early as age 8 years, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 5, 2018 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Liver Health Takes a Hit in Young Overweight Children Liver Health Takes a Hit in Young Overweight Children
Children who are obese or overweight in early childhood are at increased risk of developing signs of nonalcoholic fatty liver disease as early as age 8 years, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 5, 2018 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Fatty liver disease: Four ways to avoid the SILENT killer
NON-ALCOHOLIC fatty liver disease is one of the UK ’s biggest killers. But with diet and lifestyle changes, the condition is reversible. Here’s how to avoid the disease and try to beat it if you’ve already been diagnosed. (Source: Daily Express - Health)
Source: Daily Express - Health - April 5, 2018 Category: Consumer Health News Source Type: news

Obesity Can Lead to Liver Damage by Age 8
A new study of 635 children in Massachusetts found that a bigger waist size at age 3 increases the odds that a child will have a marker for liver damage and nonalcoholic fatty liver disease by age 8. (Source: WebMD Health)
Source: WebMD Health - April 4, 2018 Category: Consumer Health News Source Type: news

Obese children are nearly twice as likely to show signs of a life-threatening liver disease
A Columbia University study revealed 35 percent of obese children showed signs of nonalcoholic fatty liver disease, a condition that causes damage similar to that of excessive alcohol consumption. (Source: the Mail online | Health)
Source: the Mail online | Health - April 4, 2018 Category: Consumer Health News Source Type: news

Women with polycystic ovary syndrome at double risk of liver disease
Women with polycystic ovaries having a two-fold increased risk of developing non-alcoholic fatty liver disease, according to UK researchers. (Source: Nursing Times)
Source: Nursing Times - March 29, 2018 Category: Nursing Source Type: news

Empagliflozin Eyed for Fatty Liver Disease in Type 2 Diabetes Empagliflozin Eyed for Fatty Liver Disease in Type 2 Diabetes
The first trial of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes and nonalcoholic fatty liver disease indicates the drug might reduce liver fat, but the results of the small study need replication.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 22, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

High consumption of red and processed meat linked to non-alcoholic fatty liver disease and insulin resistance
(Elsevier) World meat consumption has increased during the last decades, and evidence is mounting that high consumption of red and mainly processed meat is unhealthy to humans and is related to chronic diseases such as cancer, type 2 diabetes, and cardiovascular disease. A new study published in the Journal of Hepatology adds non-alcoholic fatty liver disease (NAFLD) to the list. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 20, 2018 Category: Biology Source Type: news

Gut Microbes Transmit Susceptibility to Nonalcoholic Fatty Liver Disease Progression
Studies have expanded understanding of the role of gut microbes in nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NASH). (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Cell Signaling Pathways Point to Top Notch Solution for Fatty Liver Disease
Notch, a type of cell receptor, may be responsible for fat build up in individuals with nonalcoholic fatty liver disease. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Gastrointestinal hormone can decrease liver fat levels
According to a clinical study, published inThe Lancet, a variant of hormone FGF19 can reduce the liver fat levels of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - March 13, 2018 Category: Endocrinology Source Type: news

Post-Transplant Fatty Liver Disease on the Rise (CME/CE)
(MedPage Today) -- Over 25% of liver-transplanted patients had new-onset NAFLD (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - March 10, 2018 Category: Gastroenterology Source Type: news

Gastrointestinal hormone measurably improved symptoms of non-alcoholic fatty liver disease
(University of California - San Diego) Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The findings represent an important proof-of-concept for the compound as there are currently no Food and Drug Administration-approved treatments for NAFLD and NASH. (Source: EurekAle...
Source: EurekAlert! - Medicine and Health - March 8, 2018 Category: International Medicine & Public Health Source Type: news

Diagnostic Performance of Noninvasive Fibrosis Tests in NAFLD Diagnostic Performance of Noninvasive Fibrosis Tests in NAFLD
What factors may impact the diagnostic performance of noninvasive fibrosis tests in patients with nonalcoholic fatty liver disease? Does accuracy differ across various NAFLD subgroups?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 1, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Texas A & M-led collaborative study takes aim at non-alcoholic fatty liver disease
(Texas A&M AgriLife Communications) Texas A&M University System researchers in collaboration with the Department of Veterans Affairs and Baylor Scott& White Research Institute have completed a study identifying one of the mechanisms leading to the development of non-alcoholic fatty liver disease, or NAFLD, providing new possibilities for prevention and treatment of the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2018 Category: International Medicine & Public Health Source Type: news

Prolonged Opioids Common After Bariatric Surgery: Gastro Endo News Report
(MedPage Today) -- Also, the importance of reliable noninvasive tests for diagnosing NAFLD (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - February 21, 2018 Category: Surgery Source Type: news

Histological Disease Severity in Lean Patients With NAFLD Histological Disease Severity in Lean Patients With NAFLD
How do histological features associated with disease severity differ in lean-NAFLD versus overweight/obese-NAFLD patients?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 16, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Medical News Today: Fish oil may not be as healthful as you think, study finds
A new study finds that lifelong intake of fish or sunflower oil may damage the liver in a way that increases the risk of non-alcoholic fatty liver disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2018 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Medical News Today: Kiwi compound may prevent non-alcoholic fatty liver disease
Research suggests that a compound found in kiwi and celery may prevent fatty liver in offspring born to mothers who ate a high-fat diet in pregnancy. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 28, 2018 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Survival After HCC Treatment Among Patients With/Without NAFLD Survival After HCC Treatment Among Patients With/Without NAFLD
This study aimed to identify overall survival differences after receipt of curative treatment for NAFLD and non-NAFLD-HCC, stratified by curative treatment modality.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 26, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

BU researcher awarded NIH grant to continue research on non-alcoholic fatty liver disease
(Boston University School of Medicine) Michelle T. Long, MD, assistant professor of medicine at Boston University School of Medicine (BUSM) and a gastroenterologist at Boston Medical Center (BMC), recently was a awarded nearly $1 million dollars from the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). The five-year grant will continue to fund her research on non-alcoholic fatty liver disease (NAFLD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2018 Category: International Medicine & Public Health Source Type: news

Liver disease solutions proven to be safe and effective
(Natural News) Non-alcoholic fatty liver disease (NAFLD), the presence of excess fat in the liver, is approaching epidemic proportions – with experts estimating the prevalence at 20 to 30 percent worldwide. And, since NAFLD is strongly linked to being overweight, the alarming rise of liver disease is expected to continue. But, according to natural health... (Source: NaturalNews.com)
Source: NaturalNews.com - January 24, 2018 Category: Consumer Health News Source Type: news

Powerful food-derived antioxidant can halt, prevent fatty liver disease in mice
(University of Colorado Anschutz Medical Campus) As obesity continues to rise in the US, non-alcoholic fatty liver disease (NAFLD) has become a major public health issue, increasingly leading to cancer and liver transplants. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 22, 2018 Category: International Medicine & Public Health Source Type: news

Novartis becomes latest big-name collaborator for Chapel Hill company
On the heels of collaborations with Bristol-Myers Squibb (NYSE: BMY) and Allergan (NYSE: AGN), Chapel Hill-based clinical data company Target PharmaSolutions ’ latest collaboration is with Novartis (NYSE: NVS). Novartis will collaborate with Target on its NASH study, focused on patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). The study will ultimately enroll 15,000 patients.  While financial terms of the new collaboration are not being disclosed,… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - January 10, 2018 Category: American Health Authors: Jennifer Henderson Source Type: news

SHG Reveals Subtle Differences in Adult and Pediatric NAFLD SHG Reveals Subtle Differences in Adult and Pediatric NAFLD
A novel imaging system can reveal subtle differences in pediatric and adult patterns of steatofibrosis not captured by other methods.American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 10, 2018 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Significant Burden of NAFLD With Advanced Fibrosis in the US Significant Burden of NAFLD With Advanced Fibrosis in the US
This report assessed prevalence and predictors of significant and advanced hepatic fibrosis among US adults with NAFLD.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 5, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Noninvasive Tests for NAFLD Are Unreliable in South Asians Noninvasive Tests for NAFLD Are Unreliable in South Asians
Blood-test-based non-invasive tests for non-alcoholic fatty liver disease (NAFLD) are unreliable alternatives to liver biopsy in South Asians, new research suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 28, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Non-alcoholic fatty disease liver disease associated with higher cardiovascular risk
Results presented during the American Heart Association Scientific Sessions report that non-alcoholic fatty liver disease may have a role in cardiovascular risk.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 22, 2017 Category: Endocrinology Source Type: news

FDA Approves MRI Software for Fatty Liver Disease Screening FDA Approves MRI Software for Fatty Liver Disease Screening
The diagnosis of nonalcoholic fatty liver disease, which can rapidly progress to cirrhosis or liver cancer, could become easier with new multiparametric MRI software.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 4, 2017 Category: Consumer Health News Tags: Radiology News Source Type: news

Non-invasive Tools for Diagnosis of Liver Fibrosis in NAFLD Non-invasive Tools for Diagnosis of Liver Fibrosis in NAFLD
Can serial use of non-invasive methods such as evaluation of imaging studies, clinical scores, and biochemical markers accurately diagnose advanced liver fibrosis in patients with NAFLD?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 4, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

FDA Clearance For Perspectum Diagnostics' LiverMultiScan(TM) Means More Patients Can Benefit From Access To State-Of-The-Art Non-Invasive Diagnostic Aid For Liver Disorders
More patients can benefit from non-invasive assessment of the liver through expanded compatibility with MRI systems LiverMultiScan™ comprehensive analysis allows the clinician to visualize heterogeneous liver tissue and assist in clinical decision-makin... Diagnostics, Radiology, FDA Perspectum Diagnostics, LiverMultiScan, NAFLD (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 27, 2017 Category: Pharmaceuticals Source Type: news

New Treatments in Non-alcoholic Fatty Liver Disease New Treatments in Non-alcoholic Fatty Liver Disease
An improved understanding of the mechanisms behind NAFLD has led to new approaches to pharmacotherapy. This review presents an overview of current and investigational therapeutics.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 27, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Trends and Outcomes of NAFLD-HCC After Liver Resection Trends and Outcomes of NAFLD-HCC After Liver Resection
This review examined temporal trends for prevalence, clinical characteristics and outcomes of NAFLD-related HCC. Do these differ from HCC that developed in patients with other chronic liver diseases?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 22, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Ground-breaking € 34 million project to develop better test for liver disease
(European Association for the Study of the Liver) A pioneering European research project aims to lead to new diagnostic tests to assess patients with non-alcoholic fatty liver disease (NAFLD) and identify those most at risk for developing severe inflammation and liver scarring. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 21, 2017 Category: International Medicine & Public Health Source Type: news