UMN researchers discover important connection between cells in the liver
(University of Minnesota Medical School) University of Minnesota Medical School researchers have made a discovery which could lead to a new way of thinking about how disease pathogenesis in the liver is regulated, which is important for understanding the condition nonalcoholic fatty liver disease (NAFLD), which is incredibly common and growing. It is apparent that about 30 percent of Americans and are at risk to advance to more severe conditions such as nonalcoholic steatohepatitis (NASH), cirrhosis, cardiovascular disease, or even liver cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2018 Category: International Medicine & Public Health Source Type: news

Novel Thyroid Beta Receptor Agonist Cut LDL-C in NAFLD Patients
(MedPage Today) -- Small phase II study also found reductions in liver fat vs placebo (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 13, 2018 Category: Primary Care Source Type: news

Drug-induced Liver Injury in the Context of NAFLD Drug-induced Liver Injury in the Context of NAFLD
This article explores the pathophysiological mechanisms and reciprocity involved in NAFLD and drug-induced steatohepatitis.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 13, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Risks for Most Cancers Higher with NAFLD
(MedPage Today) -- Condition may drive obesity-related cancers (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - November 12, 2018 Category: Endocrinology Source Type: news

Impact of Diabetes on Non-invasive Fibrosis Models in NAFLD Impact of Diabetes on Non-invasive Fibrosis Models in NAFLD
Are non-invasive serum fibrosis models less accurate for diagnosing cirrhosis and predicting future HCC and liver decompensation events in NAFLD patients with diabetes versus those without?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 8, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Recent research suggests that even low exposure to glyphosate can contribute to liver damage
(Natural News) Back in 2015, the American Liver Foundation estimated that at least one in four Americans was living with non-alcoholic fatty liver disease (NAFLD), an illness that can affect even those who drink little or no alcohol. People in their 40s and 50s are most vulnerable, especially those who carry extra weight around their... (Source: NaturalNews.com)
Source: NaturalNews.com - October 29, 2018 Category: Consumer Health News Source Type: news

Clues to the link between obesity and liver cancer-and identification of a new risk group
(Monash University) New research has found a previously overlooked group of obese people may be at risk of developing deadly liver cancer. Most obese individuals who develop liver cancer first develop non-alcoholic fatty liver disease, and then the more severe non-alcoholic steatohepatitis. This can lead to cirrhosis and liver failure. However, this research reveals pathways to the development of liver cancer in obese people that are not reliant on the development of non-alcoholic steatohepatitis or cirrhosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 25, 2018 Category: Cancer & Oncology Source Type: news

Shellfish and tea? Compounds found in both protect you from a progressive form of nonalcoholic fatty liver disease
(Natural News) Sipping tea in between mouthfuls of taurine-rich shellfish sounds like a strange combination. However, Chinese researchers say this is an excellent way to protect your liver from certain diseases. Their new study shows that the combination of taurine and tea polyphenols can prevent the onset of nonalcoholic steatohepatitis (NASH). NASH is the progressive... (Source: NaturalNews.com)
Source: NaturalNews.com - October 24, 2018 Category: Consumer Health News Source Type: news

Liver fat can be quickly and significantly reduced with a gastrointestinal hormone
(Natural News) A study published in The Lancet reported that NGM282, a non-tumorigenic variant of a hormone found in the gastrointestinal tract, was able to reduce the liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). According to researchers, the findings demonstrated the potential of the compound to be used in treating both... (Source: NaturalNews.com)
Source: NaturalNews.com - October 24, 2018 Category: Consumer Health News Source Type: news

10 Ways to Keep Your Heart Healthy
No one ever had fun visiting the cardiologist. ­Regardless of how good the doc might be, it’s always a little scary thinking about the health of something as fundamental as the heart. But there are ways to take greater control—to ensure that your own heart health is the best it can be—even if you have a family history of cardiovascular disease. Although 50% of cardiovascular-disease risk is genetic, the other 50% can be modified by how you live your life, according to Dr. Eugenia Gianos, director of Women’s Heart Health at Lenox Hill Hospital in New York City. “This means you can greatly ...
Source: TIME: Health - October 17, 2018 Category: Consumer Health News Authors: Lisa Lombardi and Jamie Ducharme Tags: Uncategorized Baby Boomer Health heart health Source Type: news

Sleeping beauty helps identify genes involved in a fatty liver-associated liver cancer
(Osaka University) Hepatocellular carcinoma, a deadly form of liver cancer, is increasingly being linked to non-alcoholic fatty liver disease; however, the underlying genetic mechanism of disease progression had remained unknown. Using a Sleeping Beauty mutagenesis screen, Osaka University researchers found that Sav1 and downstream components of the Hippo signaling pathway are drivers of the development of liver cancer associated with fatty liver disease. These findings pave the way for liver cancer treatments targeting the Hippo pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 17, 2018 Category: Cancer & Oncology Source Type: news

Web-Based Lifestyle Program Works for Liver Disease Patients
TUESDAY, Oct. 16, 2018 -- Web-based programs may be effective in helping patients make lifestyle changes to control non-alcoholic fatty liver disease (NAFLD), according to a study published in the November issue of the Journal of Hepatology. Arianna... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 16, 2018 Category: Pharmaceuticals Source Type: news

Modest Alcohol Consumption May Reduce Mortality in NAFLD
FRIDAY, Oct. 12, 2018 -- For patients with nonalcoholic fatty liver disease (NAFLD), modest alcohol consumption is associated with a reduction in all-cause mortality, while drinking 1.5 or more drinks per day may increase mortality, according to a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 12, 2018 Category: Pharmaceuticals Source Type: news

Obesity, Weight Gain Linked to Fibrosis Progression in NAFLD Obesity, Weight Gain Linked to Fibrosis Progression in NAFLD
Obesity and weight gain were independently associated with an increased risk for fibrosis progression in patients with nonalcoholic fatty liver disease (NAFLD), a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 4, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Risk of NAFLD in Celiac Patients on a Gluten-free Diet Risk of NAFLD in Celiac Patients on a Gluten-free Diet
Does a gluten-free diet impact the risk of developing nonalcoholic fatty liver disease in patients with celiac disease?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 20, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Big data studies scrutinize links between fatty liver disease and how cells make energy
(American Society for Biochemistry and Molecular Biology) Three recent studies investigate changes in mitochondria, the cell's energy producers, as fatty liver disease (NAFLD) progresses to steatohepatosis (NASH). The first two studies illuminate how mitochondrial energy production stutters and fails; the third describes how changes to the liver during disease progression affect the organ's use of nutrients to produce energy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news

Severe NAFLD Boosts Liver Cancer Risk Severe NAFLD Boosts Liver Cancer Risk
People with advanced cases of nonalcoholic fatty liver disease (NAFLD) may need to be monitored for liver cancer, a large U.S. study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 6, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Severe fatty liver disease boosts risk for liver cancer
(Reuters Health) - People with advanced cases of nonalcoholic fatty liver disease (NAFLD) may need to be watched for liver cancer, a large U.S. study suggests. (Source: Reuters: Health)
Source: Reuters: Health - September 4, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Novel concepts for the diagnosis of fatty liver and personalized treatment
(Deutsches Zentrum fuer Diabetesforschung DZD) Almost one in three adults suffer from non-alcoholic fatty liver. For the affected people this increases the risk of complications such as liver cancer, diabetes, high blood pressure and stroke. In a review article in The Lancet Diabetes& Endocrinology, Nobert Stefan and Hans-Ulrich H ä ring from the DZD and Kenneth Cusi from the University of Florida summarize current research findings and show how this knowledge can be used for personalized risk prognosis and individualized treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 31, 2018 Category: International Medicine & Public Health Source Type: news

NAFLD in Psoriasis: A Consequence of Inflammatory Burden? NAFLD in Psoriasis: A Consequence of Inflammatory Burden?
This review examines the role of chronic, low-grade inflammation in the pathogenesis of NAFLD in patients with psoriasis. Could biological therapies prevent progression of NAFLD in these patients?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 27, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

More protein after weight loss may reduce fatty liver disease
(American Physiological Society) Increasing the amount of protein in the diet may reduce the liver's fat content and lower the risk of diabetes in people with nonalcoholic fatty liver disease (NAFLD). The study is published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 16, 2018 Category: International Medicine & Public Health Source Type: news

Treat your fatty liver disease naturally with a traditional Chinese herbal powder
(Natural News) A traditional Chinese herbal medicine called Sinisan can help treat nonalcoholic fatty liver disease (NAFLD), according to a study published in the journal BMC Complementary and Alternative Medicine. Researchers from Beijing University of Chinese Medicine in China evaluated the beneficial effects of Sinisan on NAFLD. Sinisan is made up of four herbal medicines:... (Source: NaturalNews.com)
Source: NaturalNews.com - August 12, 2018 Category: Consumer Health News Source Type: news

Even Light Drinking May Make Fatty Liver Disease Worse Even Light Drinking May Make Fatty Liver Disease Worse
People non-alcoholic fatty liver disease (NAFLD) may still need to avoid alcohol if they want to prevent their liver damage from getting worse, a Korean study suggests. The researchers examined data on 58,927 Korean young and middle aged adults with NAFLD who had low levels of fibrosis. After following half of these patients for at least 8.3 years, 5,630 people had progressed from low to more ...Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 10, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Diet Heavy in Meat Boosts NAFLD Risk (CME/CE)
(MedPage Today) -- Large study shows 40% increased risk in overweight, elderly patients (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - August 5, 2018 Category: Endocrinology Source Type: news

Mixed Results with MRI for Liver Triglycerides in NAFLD (CME/CE)
(MedPage Today) -- Proton density fat fraction MRI correlated with steatosis grade; suboptimal for advanced fibrosis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 25, 2018 Category: Primary Care Source Type: news

Increased Plasma Proneurotensin Levels Identify NAFLD Increased Plasma Proneurotensin Levels Identify NAFLD
A new study investigates the relationship between plasma proneurotensin levels and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.Journal of Clinical Endocrinology & Metabolism (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 23, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

TGen-led study shows DNA methylation related to liver disease among obese patients
(The Translational Genomics Research Institute) A TGen-led team has identified how DNA methylation is associated with a condition known as non-alcoholic fatty liver disease (NAFLD), which can lead to liver cirrhosis and death, and is one of the leading indicators for liver transplants. In one of the most exacting studies of its kind, TGen scientists found evidence that DNA methylation has a role in the initiation of NAFLD-related fibrosis, according to a study published in the journal Clinical Epigenetics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2018 Category: International Medicine & Public Health Source Type: news

Economic burden of fatty liver disease in US is $32 billion annually, new study finds
(Intermountain Medical Center) Nonalcoholic fatty liver disease, or NAFLD, which affects roughly 100 million Americans, costs the United States healthcare system $32 billion annually, according to a first-of-its-kind study by Intermountain Healthcare researchers on the economic impact of the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 3, 2018 Category: International Medicine & Public Health Source Type: news

Fatty liver disease symptoms: Are you at risk? These four signs could lead to organ damage
FATTY liver disease is a condition with several types - non-alcoholic fatty liver disease is one of the main types. This is usually caused by being very overweight. But before being diagnosed, what are the symptoms to look out for, and are you at risk? (Source: Daily Express - Health)
Source: Daily Express - Health - June 21, 2018 Category: Consumer Health News Source Type: news

Liver Cancer Doubled in High-Income Countries Liver Cancer Doubled in High-Income Countries
Rates of liver cancer have doubled since the 1990s in high-income countries and are largely due to infection with hepatitis B and C, as well as nonalcoholic fatty liver disease.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 18, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

High Costs for Diagnosis, Care of Nonalcoholic Fatty Liver Disease
MONDAY, June 11, 2018 -- The health care costs associated with nonalcoholic fatty liver disease (NAFLD) are considerable, especially at first diagnosis, according to a study published online May 18 in Hepatology. Alina M. Allen, M.D., from the Mayo... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2018 Category: Pharmaceuticals Source Type: news

Text Messaging Approach Improves Weight Loss in NAFLD Text Messaging Approach Improves Weight Loss in NAFLD
This study evaluated the efficacy of a text messaging intervention to improve weight loss and disease management in patients with NAFLD.Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 11, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Too young for such an "old" condition: 8-year-olds now being diagnosed with nonalcoholic fatty liver disease
(Natural News) Adults who have an unhealthy lifestyle are often diagnosed with nonalcoholic fatty liver disease (NAFLD). But according to a study, there is an alarming link “between childhood obesity and juvenile liver health problems.” The study on children involved researchers from Harvard Medical School based on Project Viva of Massachusetts. It confirmed a connection between childhood obesity and... (Source: NaturalNews.com)
Source: NaturalNews.com - June 6, 2018 Category: Consumer Health News Source Type: news

NAFLD Is a Growing Problem NAFLD Is a Growing Problem
Recent guidance from the American Association for the Study of Liver Diseases for the evaluation and management of patients with nonalcoholic fatty liver disease is profiled.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 18, 2018 Category: Consumer Health News Tags: Gastroenterology Expert Column Source Type: news

Understanding vitamin D trends in children with non-alcoholic fatty liver disease
(University of Leeds) New research charts vitamin D levels and variations in genes that determine vitamin D status in UK children diagnosed with non-alcoholic fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2018 Category: International Medicine & Public Health Source Type: news

IRE1{alpha} prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. An impaired UPR is associated with hepatic steatosis and nonalcoholic fatty liver disease (NAFLD), which is caused by lipid accumulation in the liver. We found that IRE1α was critical to maintaining lipid homeostasis in the liver by repressing the biogenesis of microRNAs (miRNAs) that regulate lipid mobilization. In mice fed normal chow, the endoribonuclease function of IRE1α processed a subse...
Source: Signal Transduction Knowledge Environment - May 15, 2018 Category: Science Authors: Wang, J.-M., Qiu, Y., Yang, Z., Kim, H., Qian, Q., Sun, Q., Zhang, C., Yin, L., Fang, D., Back, S. H., Kaufman, R. J., Yang, L., Zhang, K. Tags: STKE Research Articles Source Type: news

Gut check: Metabolites shed by intestinal microbiota keep inflammation at bay
(Tufts University) Researchers have elucidated a mechanism by which 'good' bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study, now available in the journal Cell Reports, identified two key metabolites produced by the bacteria in mice that modulate inflammation in the host and could ultimately reduce the severity of non-alcoholic fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 4, 2018 Category: International Medicine & Public Health Source Type: news

Index of NASH for Diagnosis of Steatohepatitis in NAFLD Index of NASH for Diagnosis of Steatohepatitis in NAFLD
This study examined the feasibility of a new non-invasive algorithm for the prediction of NASH--the ION index. Is it useful across different populations of patients with NAFLD?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 3, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Dietary Improvements May Prevent NAFLD Dietary Improvements May Prevent NAFLD
People who make an effort to improve their diet may have a lower risk of non-alcoholic fatty liver disease (NAFDL) than individuals who stick to unhealthy eating habits, a U.S. study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 30, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Eating a lot of processed meat increases your risk of non-alcoholic fatty liver disease and insulin resistance
(Natural News) Researchers have found another reason why eating a lot of processed meat is bad: It increases the risk of non-alcoholic fatty liver disease (NAFLD) and insulin resistance, according to a study published in the Journal of Hepatology. These results add to the increasing amount of evidence on the harmful effects of eating red... (Source: NaturalNews.com)
Source: NaturalNews.com - April 30, 2018 Category: Consumer Health News Source Type: news

BMI Trajectories in Young Adults Predict NAFLD in Middle Age BMI Trajectories in Young Adults Predict NAFLD in Middle Age
Might strategies for weight maintenance through young adulthood be more successful at preventing NAFLD than weight loss later in life?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 26, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Poverty Harms Patients With Diabetes, Fatty Liver Poverty Harms Patients With Diabetes, Fatty Liver
When patients with diabetes and nonalcoholic fatty liver disease cannot consistently afford a healthy diet, the risk for advanced hepatic fibrosis is elevated, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 17, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Gains from online lifestyle intervention similar to group program ’s for liver disease patients
In a cohort of patients with non-alcoholic fatty liver disease (NAFLD), an online lifestyle modification-focused intervention was similarly effective to a group-based program in achieving weight loss and liver enzyme normalization, according to data from an Italian study recently presented at The International Liver Congress in Paris. (Source: mobihealthnews)
Source: mobihealthnews - April 16, 2018 Category: Information Technology Source Type: news

Costs Balloon after Cirrhosis Diagnosis for NAFLD/NASH (CME/CE)
(MedPage Today) -- Experts say study emphasizes importance of identifying patients early (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 16, 2018 Category: Primary Care Source Type: news

' Well Done' Red Meat Linked to Liver Disease, Insulin Resistance'Well Done' Red Meat Linked to Liver Disease, Insulin Resistance
People who eat lots of processed and red meat are at increased risk of developing non-alcoholic fatty liver disease and insulin resistance, especially if they like their steak well done, an Israeli study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 13, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Eating red meat boosts the risk of deadly liver disease
Israeli scientists have found the risk of non-alcoholic fatty liver disease is highest for those who enjoy their steak 'well done'. The conclusion was made based on a study of 789 adults. (Source: the Mail online | Health)
Source: the Mail online | Health - April 13, 2018 Category: Consumer Health News Source Type: news

Germany: compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
(European Association for the Study of the Liver) Compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
(European Association for the Study of the Liver) A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

Empagliflozin Trims Liver Fat in Patients With T2D and NAFLD Empagliflozin Trims Liver Fat in Patients With T2D and NAFLD
Dr Kuchay discusses his findings from the E-LIFT study.Endocrine Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 9, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Commentary Source Type: news

PCOS linked to increased liver disease risk
According to a study, published inPLOS Medicine, women with PCOS have double the risk of developing nonalcoholic fatty liver disease.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 6, 2018 Category: Endocrinology Source Type: news