Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway

In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy. Introduction Nonalcoholic fatty liver disease (NAFLD) has become a worldwide health concern due to the increased incidence of obesity and diabetes. In addition, NAFLD is closely associated with the risk factors of coronary heart disease, such as metabolic syndrome, diabetes mellitus, and dyslipidemia, which are considered to be the leading causes of death (Wiest et al., 2017). Although our understanding of the pathogenesis of NAFLD has significantly improved, there is still no effective medication for this disease that is approved by FDA (Neuschwander-Tetri et al., 2015). Thus, development of new therapeutic strategies capable of alleviating NALFD is urgently needed. Lipid homeostasis is maintained by the balance between lipid synthesis and lipid metabolism, and the latter is critical for the progression of hepatic steatosis (Zhang et al., 2015). Autophagy is a genetically programmed, evolutionarily conserved catabolic process that promotes cell survival and modulates intracellular homeostasis (Piekarski et al., 2018). Autophagy has many other pathophysiological functions in lipid metabolism aside from removing intracellular pathogens and damaged cell organelles, such as preventing hepatic steatosis by facilitating the hydrolysis of intracellular lipids, as found in recent studies (Liu et al., 2015; Huang et al., 2017). After being activated by ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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