Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway

In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy. Introduction Nonalcoholic fatty liver disease (NAFLD) has become a worldwide health concern due to the increased incidence of obesity and diabetes. In addition, NAFLD is closely associated with the risk factors of coronary heart disease, such as metabolic syndrome, diabetes mellitus, and dyslipidemia, which are considered to be the leading causes of death (Wiest et al., 2017). Although our understanding of the pathogenesis of NAFLD has significantly improved, there is still no effective medication for this disease that is approved by FDA (Neuschwander-Tetri et al., 2015). Thus, development of new therapeutic strategies capable of alleviating NALFD is urgently needed. Lipid homeostasis is maintained by the balance between lipid synthesis and lipid metabolism, and the latter is critical for the progression of hepatic steatosis (Zhang et al., 2015). Autophagy is a genetically programmed, evolutionarily conserved catabolic process that promotes cell survival and modulates intracellular homeostasis (Piekarski et al., 2018). Autophagy has many other pathophysiological functions in lipid metabolism aside from removing intracellular pathogens and damaged cell organelles, such as preventing hepatic steatosis by facilitating the hydrolysis of intracellular lipids, as found in recent studies (Liu et al., 2015; Huang et al., 2017). After being activated by ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Conclusions: The constantly increasing prevalence of NAFLD in the general population can contribute to a growing role of NAFLD/NASH in HCC epidemiology. Moreover, some particular challenges specific for patients with liver steatosis may impede proper HCC diagnosis, treatment and follow-up. PMID: 31631714 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Beylacq L, Baer E, Choquet O, Dupre HL, Capdevila X Abstract BACKGROUND: Ultrasound-guided axillary block is widely used in daily practice for upper limb orthopedic surgery. A simple, safe, efficacious and time-saving technique is mandatory to optimize surgical turnover and costs. In this perspective, we compared, in a randomized, single-blinded study, a standardized perifascial technique and the selective perineural technique. METHODS: Forty-two patients scheduled for elective hand surgery were randomly assigned to receive 20 ml of 10 mg/mL mepivacaïne, either selectively around each of the radia...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
CONCLUSIONS: Although consumption of a WPND was associated with a larger estimated GV in this pilot study, a larger study is necessary to conclude whether patients must fast longer than 2 hours after consumption of a WPND. PMID: 31630511 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
CONCLUSIONS: Perioperative, i.v. lidocaine administration influences postoperative serum concentrations of endocannabinoids and NAEs in children. PMID: 31630508 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Catheter use in regional anesthesia: pros &cons. Minerva Anestesiol. 2019 Oct 14;: Authors: Capdevila X, Iohom G, Choquet O, Delaney P, Apan A Abstract Continuous peripheral nerve blocks refer to a local anesthetic solution administered via perineurally placed catheters in an effort to extend the benefits of a single-shot peripheral nerve block. They offer several advantages in the postoperative period including excellent analgesia, reduced opioid consumption and associated side effects, enhanced rehabilitation and improved patient satisfaction. The current trend towards less invasive, one-day surg...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Romagnoli S, Franchi F, Ricci Z Abstract Individual response to sedatives and hypnotics is characterized by high variability and the identification of a personalized dose during anesthesia in the operating room and during sedation in the intensive care unit may have beneficial effects. Although the brain is the main target of general intravenous and inhaled anesthetic agents, electroencephalography (EEG) is not routinely utilized to explore cerebral response to sedation and anesthesia probably because EEG trace reading is complex and requires encephalographers' skills. Automated processing algorithms (proc...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
CONCLUSIONS: In elderly individuals with T1DM, we found associations between dLOC and cognition overall and in men but not women. Underlying sex differences should be considered in future research or interventions on psychosocial characteristics for cognition. PMID: 31633555 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
CLINICS IN PERINATOLOGY
Source: Clinics in Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Authors: special issue: “Focus on pediatric nephrology”, Sestito S, Falvo F, Sallemi A, Petrisano M, Scuderi MG, Tarsitano F, D'Angelo G, Betta P, Roppa K, Parisi F, Pensabene L, Fede C, Chimenz R, Concolino D Abstract Anderson-Fabry Disease (AFD) is a rare, X-linked inborn error of glycosphingolipid catabolism caused by a deficient or absent activity of the lysosomal enzyme, α-galactosidase A, resulting in the progressive multisystem lysosomal accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3). Among the wide spectrum of clinical signs and symptoms and the life-threatening com...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: special issue: “Focus on pediatric nephrology”, Scuderi MG, Spampinato G, Milazzo G, Betta P, Fusco M, Arena S, Falsaperla M, Chimenz R, Di Benedetto V Abstract Pelviureteric junction obstruction (PUJO) due to intrinsic or extrinsic causes is a common problem in childhood. Extrinsic compression by a lower pole-crossing blood vessel can present symptomatically in older children. In these cases, laparoscopies Vascular Hitch can represent a valid alternative to pyeloplasty dismembered. We analyzed the data of 4 children affected by extrinsic PUJO treated at our institution with the laparoscopic Va...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
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