Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway

Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Committee of the China–Japan Friendship Hospital. Author Contributions LP and PL designed the experiments. YW, ZS, QW, and YL performed the experiments. XL, TZ, NL, and NZ analyzed and interpreted the data. HZ and QL drafted the manuscript. Funding This work was supported by National Natural Science Foundation of China (81620108031 and 81670758), Beijing Municipal Natural Science Foundation of China (7182147), Capital’s Funds for Health Improvement and Research (2018-2-4062), and Fundamental Research Funds of the Chinese Academy of Medical Sciences (2018RC310023). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be f...
Source: Frontiers in Physiology - Category: Physiology Source Type: research