A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models
Progressive kidney diseases are often associated with scarring of the kidney’s filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited forms of FSGS are caused by Rac1-activating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podocytes. Whether TRPC5 activity mediates FSGS onset and progression is unknown. We identified a small molecule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuri...
Source: ScienceNOW - December 7, 2017 Category: Science Authors: Zhou, Y., Castonguay, P., Sidhom, E.-H., Clark, A. R., Dvela-Levitt, M., Kim, S., Sieber, J., Wieder, N., Jung, J. Y., Andreeva, S., Reichardt, J., Dubois, F., Hoffmann, S. C., Basgen, J. M., Montesinos, M. S., Weins, A., Johnson, A. C., Lander, E. S., Ga Tags: Medicine, Diseases reports Source Type: news
What is the Genetic Inheritance of Alport Syndrome?
Discussion Alport Syndrome is a genetic disease classically associated with progressive renal disease often leading to end stage renal disease, variable sensory neuronal deafness and ocular findings (perimacular retinopathy). A. Cecil Alport built on the work of others evaluating families with nephritis and/or hematuria. However he very clearly describes the third generation of a family with an X-linked dominant pattern and also emphasizes the syndrome’s associated deafness. Alport writes: “It will be seen from this that nearly all the children of three generations of one family suffer from hematuria or nep...
Source: PediatricEducation.org - August 28, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
The Effects of Short Sleep Duration on Proteinuria and CKD The Effects of Short Sleep Duration on Proteinuria and CKD
Are short sleepers at a higher risk of developing proteinuria and chronic kidney disease?Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 25, 2017 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice
Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin receptor (APLNR, or APJ), is a circulating hormone secreted by the placenta. Elabela but not Apelin knockout pregnant mice exhibit PE-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis. In mice, infusion of exogenous ELA normalizes hypertension, proteinuria, and birth weight. ELA, ...
Source: ScienceNOW - August 17, 2017 Category: Science Authors: Ho, L., van Dijk, M., Chye, S. T. J., Messerschmidt, D. M., Chng, S. C., Ong, S., Yi, L. K., Boussata, S., Goh, G. H.-Y., Afink, G. B., Lim, C. Y., Dunn, N. R., Solter, D., Knowles, B. B., Reversade, B. Tags: Development reports Source Type: news
Anti-preeclampsia hormone discovered
A study published inScience reports on the discovery of a micropeptide that protects pregnant mice from proteinuria and hypertension, two hallmarks of preeclampsia.The Scientist (Source: Society for Endocrinology)
Source: Society for Endocrinology - July 7, 2017 Category: Endocrinology Source Type: news
YAP-mediated mechanotransduction determines the podocytes response to damage
Podocytes are terminally differentiated cells of the kidney filtration barrier. They are subjected to physiological filtration pressure and considerable mechanical strain, which can be further increased in various kidney diseases. When injury causes cytoskeletal reorganization and morphological alterations of these cells, the filtration barrier may become compromised and allow proteins to leak into the urine (a condition called proteinuria). Using time-resolved proteomics, we showed that podocyte injury stimulated the activity of the transcriptional coactivator YAP and the expression of YAP target genes in a rat model of g...
Source: Signal Transduction Knowledge Environment - April 11, 2017 Category: Science Authors: Rinschen, M. M., Grahammer, F., Hoppe, A.-K., Kohli, P., Hagmann, H., Kretz, O., Bertsch, S., Höhne, M., Göbel, H., Bartram, M. P., Gandhirajan, R. K., Krüger, M., Brinkkoetter, P.-T., Huber, T. B., Kann, M., Wickström, S. Tags: STKE Research Articles Source Type: news
Maternal Smoking During Pregnancy Linked to Child Proteinuria Maternal Smoking During Pregnancy Linked to Child Proteinuria
Women who smoke during pregnancy may be more likely to have children with kidney damage than mothers who steer clear of cigarettes, a study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2016 Category: Consumer Health News Tags: Pediatrics News Source Type: news
Smoking in Pregnancy Tied to Kidney Damage in Kids
THURSDAY, Dec. 22, 2016 -- Children of mothers who smoke during pregnancy may be at increased risk for kidney damage, a new study warns. Researchers looked at test results for excessive protein in the urine (proteinuria) -- which is a sign of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 22, 2016 Category: Journals (General) Source Type: news
Dual-Pathway Inhibitor Targets Glomerular Disease Dual-Pathway Inhibitor Targets Glomerular Disease
A hypertension drug might benefit patients with primary focal segmental glomerulosclerosis, a rare kidney disease characterized by proteinuria, suggest early results from the DUET trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 28, 2016 Category: Consumer Health News Tags: Nephrology News Source Type: news
Three risk factors suggest a reduction in healthy renal function in patients with diabetes
Patients with diabetes and suffering from acute kidney injury (AKI), proteinuria and uncontrolled blood sugar experience a sharp reduction in the number of years they have healthy renal function before being forced onto dialysis, according to researchers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 21, 2016 Category: Science Source Type: news
Three risk factors suggest a reduction in healthy renal function in patients with diabetes
(University of Cincinnati Academic Health Center) Patients with diabetes and suffering from acute kidney injury, proteinuria and uncontrolled blood sugar experience a sharp reduction in the number of years they have healthy renal function before being forced onto dialysis, according to researchers at the University of Cincinnati College of Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2016 Category: Global & Universal Source Type: news
Mallinckrodt starts enrolment in Phase lV trial of acthar gel to treat FSGS
Global specialty biopharmaceutical company Mallinckrodt has enrolled patients for its Phase lV clinical trial, PODOCYTE, of acthar gel (repository corticotropin injection) for inducing remission of proteinuria due to treatment-resistant or treatment-… (Source: Drug Development Technology)
Source: Drug Development Technology - May 17, 2016 Category: Pharmaceuticals Source Type: news
Utility of Screening for Proteinuria, Glucosuria, and UTI Throughout Pregnancy With Urine Dipstick for Family Medicine OB Patients at an Academic Center (Pamela Kum MSIV)
(Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)
Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded - January 19, 2016 Category: Primary Care Source Type: news
Your NEJM Group Today: Proteinuria & Kidney Mass; Antidepressants Overprescribed?; California Hospitalist Opportunities (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Case Record: … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 17, 2015 Category: Primary Care Source Type: news
Blood Pressure, Proteinuria Reduction Key in IgA NephropathyBlood Pressure, Proteinuria Reduction Key in IgA Nephropathy
For the majority of patients with IgA nephropathy, optimal supportive care is as protective against loss of renal function over time as immunosuppression, data from the STOP-IgAN show. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 12, 2015 Category: Consumer Health News Tags: Nephrology News Source Type: news
How Long Do Creatine Kinase Levels Remain Elevated After Exercise?
Discussion Acute rhabdomyolysis is an emergency that can cause acute renal failure (especially acute tubular necrosis caused by myoglobinemia) and electrolyte abnormalities. Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed. Acute exertional rhabdomyolysis or unrecognized muscle injury can occur in underconditioned persons and even trained athletes who increase their exertion or exercise. Being unaccustomed to the ambient conditions such as heat, humidity and sun can also increase fluid loss and the risk of muscle injury. An overview and differential diagnosis of rhab...
Source: PediatricEducation.org - April 13, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
What Causes Proteinuria?
Discussion Proteinuria occurs relatively often in pediatric practice with 5-15% of school children having transient proteinuria, the most common cause. However, proteinuria can be a sign of kidney disease. Therefore, it is important to evaluate the proteinuria in light of the clinical situation. A good history and physical examination along with a full urinalysis and/or BUN and creatinine, or urine protein/creatinine ratio may be all that is necessary. Another patient with edema, hypertension or hematuria needs a fuller evaluation and treatment. Proteinuria is usually categorized into three groups to assist with evaluation...
Source: PediatricEducation.org - August 18, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Proteinuria often undertreated in hospital settings
Read the full story on MD Consult: Proteinuria often undertreated in hospital settings (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - May 7, 2014 Category: Journals (General) Source Type: news
Proteinuria Often Untreated in Hospital
LAS VEGAS (MedPage Today) -- Although it's easily managed, proteinuria often goes untreated in the hospital, researchers reported here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 24, 2014 Category: Cardiology Source Type: news
Closer to detecting preeclampsia: Biomarkers found in urine, blood
Researchers have found a set of biomarkers in urine and serum samples that were different between women with preeclampsia, women with normal pregnancies and women who were not pregnant. These biomarkers tell the story of what is happening to the metabolism of women who have developed preeclampsia. Preeclampsia is a disease of pregnancy that has its origins in insufficient development of the placenta during the first trimester, but usually only presents itself close to term, causing high blood pressure (hypertension) and proteins in the urine (proteinuria) of the affected women. The syndrome can be dangerous for both mother...
Source: ScienceDaily Headlines - March 17, 2014 Category: Science Source Type: news
Soft drinks and sugar in the diet may have negative effects on the kidneys
Two new studies highlight the potential negative effects that soft drinks and sugar can have on kidney health. Results of these studies were presented at ASN Kidney Week 2013 at the Georgia World Congress Center in Atlanta, GA. In one study, researchers led by Ryohei Yamamoto, MD, PhD (Osaka Univ Graduate School of Medicine, in Japan) found that consuming at least two soft drinks per day is linked with proteinuria - or increased excretion of protein in the urine, which is a hallmark of kidney dysfunction... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 12, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news
Orencia Slows Proteinuria in Renal Disease (CME/CE)
ATLANTA (MedPage Today) -- Proteinuria resolved partly or completely in a small group of patients with focal segmental glomerulosclerosis treated with abatacept, according to a study reported here. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 9, 2013 Category: Primary Care Source Type: news
New pre-eclampsia test 'shows promise'
Conclusion The researchers say this is the largest and first prospective study to look at PIGF levels in women with suspected pre-eclampsia. Overall, this study provides early positive findings of a diagnostic test for use in pregnant women with suspected pre-eclampsia. The researchers point out that it is known that plasma PIGF levels normally decline in the latter part of the third trimester (weeks 29 to 40), which reduces the PIGF test performance after 35 weeks gestation. All new screening and diagnostic tests need to weigh up the benefits against the risks. The benefits of the test could include earlier de...
Source: NHS News Feed - November 5, 2013 Category: Consumer Health News Tags: Pregnancy/child Source Type: news
A high-fat diet induces preeclampsia-like symptoms in pregnant rats
Preeclampsia is a relatively common pregnancy disorder, characterized by primary hypertension and proteinuria. In patients with severe preeclampsia, eclampsia can develop, causing nervous system symptoms and signs. In the clinic, some patients with preeclampsia suffer from eclampsia even with minimal blood pressure changes. Thus, the pathogenesis of hypertensive encephalopathy cannot fully explain the epilepsy-like attacks in eclampsia patients. We know that changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 11, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news
Protein In The Urine Linked To Life Expectancy
Pee in a cup and you might get a clue as to how much longer you will live. A new report published online today in the National Kidney Foundation's American Journal of Kidney Diseases shows a strong correlation between levels of protein in the urine, or proteinuria, and mortality. "Our report shows that both men and women with higher levels of proteinuria had substantially reduced life expectancy in comparison to people with relatively low levels of proteinuria," said the report's lead author, Dr. Tanvir Chowdhury Turin of the University of Calgary... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 3, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news
Horizon scanning: Drisapersen linked to serious side effects and hospitalisation according to safety data from trial investigating the drug in Duchenne muscular dystrophy
Source: BioSpace Area: News BioSpace reports that patients enrolled in an early stage trial investigating the use of drisapersen (GSK-2402968) in Duchenne muscular dystrophy (DMD) have been hospitalised due to kidney toxicity and low platelet counts. The report is based on data presented at a research meeting in Rome. GlaxSmithKline (GSK) has released some safety data from early stage clinical trials previously too and these mainly reported cases of proteinuria and decreased thrombocytes. According to the BioSpace report, four DMD) patients treated with drisapersen required hospitalisation due to thrombocytopenia and &qu...
Source: NeLM - News - March 1, 2013 Category: Drugs & Pharmacology Source Type: news
Meta-analysis: Efficacy and safety of dual blockade of the renin-angiotensin system
The objective of the current systematic review and meta-analysis was to compare the long term efficacy of dual RAS blockade (any two of ACE inhibitors, angiotensin receptor blockers, or aliskiren) with monotherapy, and to evaluate adverse events in patients receiving dual therapy compared with monotherapy. A systematic literature search (PubMed, Embase, Cochrane central register of controlled trials; Jan 1990-Aug 2012; no language restriction) identified 33 RCTs (total n=68,405; 71% men) reporting the outcomes of ... (Source: NeLM - Cardiovascular Medicine)
Source: NeLM - Cardiovascular Medicine - January 29, 2013 Category: Cardiology Source Type: news
IGFBP2 predicts renal function in diabetes
This study by Narayanan and colleagues points towards a potential new clinical biomarker for the long-term outcome of diabetic kidney disease. The IGF family of proteins has been repeatedly implicated in the development of diabetic nephropathy, a major complication of diabetes and the most common end-stage renal disease. In a cohort of 436 type 2 diabetics, Narayanan and colleagues found that a high IGFBP2 concentration at baseline was associated with a decreased glomerular filtration rate over an 8-year period and an increase in proteinuria, indicative of longitudinal deterioration in renal function. Narayanan et al. (201...
Source: Society for Endocrinology - January 8, 2013 Category: Endocrinology Source Type: news
Preeclampsia: Pathophysiology, Management, and Maternal and Fetal Sequelae
Preeclampsia is a unique, complicated problem of pregnancy that is prevalent worldwide. The maternal effects of severe disease may involve multiple organ systems. Consequences of disease for the infant include possible prematurity, fetal growth restriction, placental abruption, or intrauterine fetal demise. In addition, long-term effects of disease have been studied in both mothers and children. Although the exact cause of preeclampsia is not fully understood, increasing evidence points to abnormal placentation and an imbalance of antiangiogenic factors. Specifically, soluble Fms-like tyrosine kinase-1 has been investigate...
Source: NeoReviews recent issues - January 1, 2013 Category: Pediatrics Authors: McDonnold, M., Olson, G. Tags: Fetus and Newborn Infant Articles Source Type: news
KCA-ASCO Young Investigator Award
KCA and the and the ASCO Grants Selection Committee announce the selection of the 2007 Young Investigator Award: Patricia Tang, MD, Princess Margaret Hospital Abstract With the advent of anti-angiogenic therapies (AAT) for cancer treatment, a number of adverse effects have been identified in patients; importantly these include proteinuria (due to disruption of the glomerular filtration barrier) and hypertension. Hypertension appears to be a class effect of AAT, whereas proteinuria has been reported with bevacizumab, VEGF Trap, and AZD2171. The physiological mechanisms underlying the hypertension ...
Source: Kidney Cancer Association - March 4, 2007 Category: Urology & Nephrology Source Type: news