Longitudinal plasma metabolome patterns and relation to kidney function and proteinuria in pediatric chronic kidney disease
CONCLUSION: We characterized longitudinal plasma metabolomic patterns associated with eGFR and UPCR in a large pediatric CKD population. Many of these metabolite signals have been associated with CKD progression, etiology, and proteinuria in previous CKD Biomarkers Consortium studies. There were also novel metabolite associations with eGFR and proteinuria detected.PMID:38709558 | DOI:10.2215/CJN.0000000000000463 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 6, 2024 Category: Urology & Nephrology Authors: Arthur M Lee Yunwen Xu Jian Hu Rui Xiao Stephen R Hooper Erum A Hartung Josef Coresh Eugene P Rhee Ramachandran S Vasan Paul L Kimmel Bradley A Warady Susan L Furth Michelle R Denburg CKD Biomarkers Consortium Source Type: research
Longitudinal plasma metabolome patterns and relation to kidney function and proteinuria in pediatric chronic kidney disease
CONCLUSION: We characterized longitudinal plasma metabolomic patterns associated with eGFR and UPCR in a large pediatric CKD population. Many of these metabolite signals have been associated with CKD progression, etiology, and proteinuria in previous CKD Biomarkers Consortium studies. There were also novel metabolite associations with eGFR and proteinuria detected.PMID:38709558 | DOI:10.2215/CJN.0000000000000463 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 6, 2024 Category: Urology & Nephrology Authors: Arthur M Lee Yunwen Xu Jian Hu Rui Xiao Stephen R Hooper Erum A Hartung Josef Coresh Eugene P Rhee Ramachandran S Vasan Paul L Kimmel Bradley A Warady Susan L Furth Michelle R Denburg CKD Biomarkers Consortium Source Type: research
GSE218376 Spatiotemporal landscape of kidney tubular responses to glomerular proteinuria
Contributors : Anna Faivre ; Milica Bugarski ; Anna Rinaldi ; Thomas Verissimo ; Imene B Sakhi ; David Legouis ; Sara Correia ; Monika Kaminska ; Delal Dalga ; Pietro E Cipp à ; Sophie de Seigneux ; Andrew HallSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProteinuria is a cardinal feature of glomerular diseases and an important risk factor for tubulo-interstitial damage, progressive decline in kidney function, and cardiovascular complications, but the precise effects of proteinuria on tubules were previously unclear. Here, using an established mouse model of glomerulopath...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Preterm Preeclampsia as an Independent Risk Factor for Thromboembolism in a Large National Cohort
Preterm preeclampsia, a product of vascular dysfunction, is associated with prolonged hospital admission and proteinuria, significant risk factors for thromboembolism in pregnancy. The risk of thromboembolism in preterm preeclampsia warrants further investigation. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 4, 2024 Category: OBGYN Authors: Lara Slesnick, Mary Nicole Nienow-Birch, Calla Holmgren, Rachel Harrison Tags: Original Research: Obstetrics Source Type: research
Efficacy and safety of transarterial chemoembolization combined with targeted therapy and immunotherapy versus with targeted monotherapy in unresectable hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: Current evidence suggests that, on the basis of TACE combined with targeted therapy, the addition of immunotherapy provides better clinical efficacy and survival benefits for unresectable HCC patients, with good tolerability.PMID:38701263 | DOI:10.1097/MD.0000000000038037 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Jingwen Feng Yi Zhao Lin Zhai Jingxu Zhou Source Type: research
Spectrum of renal disease in scleroderma other than scleroderma renal crisis: A review of the literature
CONCLUSION: The spectrum of kidney involvement in SSc can range from asymptomatic reduction of the glomerular filtration rate to life-threatening scleroderma renal crisis. Therefore, it is essential that physicians closely monitor renal function in these patients for any emerging renal dysfunction.PMID:38699985 | DOI:10.5414/CN111243 (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 3, 2024 Category: Urology & Nephrology Authors: Larabe Farrukh Virginia Steen Lee Shapiro Geovani Faddoul Swati Mehta Source Type: research
Nephrotic Syndrome Complicated with Familial Hypocalciuric Hypercalcemia in an Infant: A Case Report and Comprehensive Literature Review
CONCLUSIONS: This case report is the first documenting familial hypocalciuric hypercalcemia in a child with primary nephrotic syndrome and delineates the familial pedigree. While familial hypocalciuric hypercalcemia is infrequent, our findings affirm its generally benign nature. A critical aspect of patient care involves monitoring for potential complications, including acute pancreatitis or chondrocalcinosis. The indispensability of genetic studies in both diagnosis and the differentiation of related conditions is underscored, emphasizing their pivotal role in enhancing our understanding of this rare yet clinically signif...
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Min Yu Mei Xue Xiaoyan Fan Chunlin Gao Zhengkun Xia Source Type: research
Spectrum of renal disease in scleroderma other than scleroderma renal crisis: A review of the literature
CONCLUSION: The spectrum of kidney involvement in SSc can range from asymptomatic reduction of the glomerular filtration rate to life-threatening scleroderma renal crisis. Therefore, it is essential that physicians closely monitor renal function in these patients for any emerging renal dysfunction.PMID:38699985 | DOI:10.5414/CN111243 (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 3, 2024 Category: Urology & Nephrology Authors: Larabe Farrukh Virginia Steen Lee Shapiro Geovani Faddoul Swati Mehta Source Type: research
Nephrotic Syndrome Complicated with Familial Hypocalciuric Hypercalcemia in an Infant: A Case Report and Comprehensive Literature Review
CONCLUSIONS: This case report is the first documenting familial hypocalciuric hypercalcemia in a child with primary nephrotic syndrome and delineates the familial pedigree. While familial hypocalciuric hypercalcemia is infrequent, our findings affirm its generally benign nature. A critical aspect of patient care involves monitoring for potential complications, including acute pancreatitis or chondrocalcinosis. The indispensability of genetic studies in both diagnosis and the differentiation of related conditions is underscored, emphasizing their pivotal role in enhancing our understanding of this rare yet clinically signif...
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Min Yu Mei Xue Xiaoyan Fan Chunlin Gao Zhengkun Xia Source Type: research
Spectrum of renal disease in scleroderma other than scleroderma renal crisis: A review of the literature
CONCLUSION: The spectrum of kidney involvement in SSc can range from asymptomatic reduction of the glomerular filtration rate to life-threatening scleroderma renal crisis. Therefore, it is essential that physicians closely monitor renal function in these patients for any emerging renal dysfunction.PMID:38699985 | DOI:10.5414/CN111243 (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 3, 2024 Category: Urology & Nephrology Authors: Larabe Farrukh Virginia Steen Lee Shapiro Geovani Faddoul Swati Mehta Source Type: research
Nephrotic Syndrome Complicated with Familial Hypocalciuric Hypercalcemia in an Infant: A Case Report and Comprehensive Literature Review
CONCLUSIONS: This case report is the first documenting familial hypocalciuric hypercalcemia in a child with primary nephrotic syndrome and delineates the familial pedigree. While familial hypocalciuric hypercalcemia is infrequent, our findings affirm its generally benign nature. A critical aspect of patient care involves monitoring for potential complications, including acute pancreatitis or chondrocalcinosis. The indispensability of genetic studies in both diagnosis and the differentiation of related conditions is underscored, emphasizing their pivotal role in enhancing our understanding of this rare yet clinically signif...
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Min Yu Mei Xue Xiaoyan Fan Chunlin Gao Zhengkun Xia Source Type: research
Spectrum of renal disease in scleroderma other than scleroderma renal crisis: A review of the literature
CONCLUSION: The spectrum of kidney involvement in SSc can range from asymptomatic reduction of the glomerular filtration rate to life-threatening scleroderma renal crisis. Therefore, it is essential that physicians closely monitor renal function in these patients for any emerging renal dysfunction.PMID:38699985 | DOI:10.5414/CN111243 (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 3, 2024 Category: Urology & Nephrology Authors: Larabe Farrukh Virginia Steen Lee Shapiro Geovani Faddoul Swati Mehta Source Type: research
Nephrotic Syndrome Complicated with Familial Hypocalciuric Hypercalcemia in an Infant: A Case Report and Comprehensive Literature Review
CONCLUSIONS: This case report is the first documenting familial hypocalciuric hypercalcemia in a child with primary nephrotic syndrome and delineates the familial pedigree. While familial hypocalciuric hypercalcemia is infrequent, our findings affirm its generally benign nature. A critical aspect of patient care involves monitoring for potential complications, including acute pancreatitis or chondrocalcinosis. The indispensability of genetic studies in both diagnosis and the differentiation of related conditions is underscored, emphasizing their pivotal role in enhancing our understanding of this rare yet clinically signif...
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Min Yu Mei Xue Xiaoyan Fan Chunlin Gao Zhengkun Xia Source Type: research
Remission induced by renal protective therapy in nephrotic syndrome with thin basement membrane in an older patient: a case report
ConclusionsThis case illustrated the novel outcomes of combining medical treatment without steroid use for nephrotic syndrome with thin glomerular basement membrane disease. At the time of writing this report, the patient ’s renal function was stable and she was free of edema, although moderate proteinuria and occult hematuria persisted. The final diagnosis was uncertain because of the lack of genetic investigation; however, the response to the aforementioned medical treatment suggests the effectiveness of the supp ortive therapy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 3, 2024 Category: General Medicine Source Type: research
Renal histiocytic fibrillary inclusions in a patient with new-onset proteinuria and monoclonal gammopathy
(Source: Virchows Archiv)
Source: Virchows Archiv - May 3, 2024 Category: Pathology Source Type: research
