Practice Patterns and Approach to Childhood Lupus Nephritis in Saudi Arabia
This study aimed to explore the current practices of pediatric rheumatologists and nephrologists for the diagnosis, management, and monitoring of lupus nephritis (LN) in Saudi Arabia through a survey. Among the 61 respondents, 54.1% were pediatric nephrologists and 49.9% were pediatric rheumatologists. Predominantly, the participating physicians received training either nationally (57%) or in North America (45%). Most of the respondents (77%) did not have a combined rheumatology-nephrology clinic, primarily because of space or time limitations (75%), or a lack of the other specialty (13%). In terms of the decision to reque...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Abdulaziz AlMutairi Sulaiman M Al-Mayouf Jameela Kari Emtenan Basahl Mohammed Nashawi Source Type: research
A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study
This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (&...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aditya Mahaseth Bishnu Pahari Madhav Ghimire Sushil Rayamajhi Source Type: research
Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria
This study aimed to assess the role of lisinopril, an ACE inhibitor, in reducing proteinuria in SCA patients. Thirty-five patients older than 15 years with known SCA (HbSS or HbS-β0) and a 24-h urinary protein level of 150 mg or more participated in this study. Urine was collected over 24 h to quantify proteinuria. The patients had a mean age of 28.5 ± 6.98 years. The median 24-h urinary protein before treatment was 0.3006 g and that after treatment was 0.150 g (P = 0.01). After a median follow-up of 38 months, 24-h urinary protein decreased in 27 (77%) patients and normalized in 18 (52%) patients. Urinary protein increa...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aamer Aleem Abdulrahman Al-Sultan Abdulkareem Alsuwaida Khalid Alsaleh Farjah Algahtani Abdulkareem Almomen Mohammad Sharif Ghazi S Alotaibi Source Type: research
Membranoproliferative Glomerulonephritis Type I Associated with Intravenous Immunoglobulin Administration Arising in a Child with X-Linked Agammaglobulinemia: A Case Report and a Reappraisal
Saudi J Kidney Dis Transpl. 2023 Nov 1;34(6):660-665. doi: 10.4103/sjkdt.sjkdt_133_23. Epub 2024 May 9.ABSTRACTIn 1952, X-linked agammaglobulinemia (XLA) was discovered as a rare inherited disorder. It markedly compromises the ability of the body to combat infectious microorganisms. Membranoproliferative glomerulonephritis (MPGN) Type I is characterized by subendothelial immune complex deposits. Patients with XLA can rarely develop immune-complex-induced diseases. Here, we report a case of MPGN Type I in a 12-year-old male patient with a past and family history of XLA. The patient presented with fever, productive cough, vo...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Mahmoud Rezk Abdelwahed Hussein Mashair Babiker Sadaf Asim Mohmmed Elsamwal Source Type: research
Practice Patterns and Approach to Childhood Lupus Nephritis in Saudi Arabia
This study aimed to explore the current practices of pediatric rheumatologists and nephrologists for the diagnosis, management, and monitoring of lupus nephritis (LN) in Saudi Arabia through a survey. Among the 61 respondents, 54.1% were pediatric nephrologists and 49.9% were pediatric rheumatologists. Predominantly, the participating physicians received training either nationally (57%) or in North America (45%). Most of the respondents (77%) did not have a combined rheumatology-nephrology clinic, primarily because of space or time limitations (75%), or a lack of the other specialty (13%). In terms of the decision to reque...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Abdulaziz AlMutairi Sulaiman M Al-Mayouf Jameela Kari Emtenan Basahl Mohammed Nashawi Source Type: research
A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study
This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (&...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aditya Mahaseth Bishnu Pahari Madhav Ghimire Sushil Rayamajhi Source Type: research
Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria
This study aimed to assess the role of lisinopril, an ACE inhibitor, in reducing proteinuria in SCA patients. Thirty-five patients older than 15 years with known SCA (HbSS or HbS-β0) and a 24-h urinary protein level of 150 mg or more participated in this study. Urine was collected over 24 h to quantify proteinuria. The patients had a mean age of 28.5 ± 6.98 years. The median 24-h urinary protein before treatment was 0.3006 g and that after treatment was 0.150 g (P = 0.01). After a median follow-up of 38 months, 24-h urinary protein decreased in 27 (77%) patients and normalized in 18 (52%) patients. Urinary protein increa...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aamer Aleem Abdulrahman Al-Sultan Abdulkareem Alsuwaida Khalid Alsaleh Farjah Algahtani Abdulkareem Almomen Mohammad Sharif Ghazi S Alotaibi Source Type: research
Membranoproliferative Glomerulonephritis Type I Associated with Intravenous Immunoglobulin Administration Arising in a Child with X-Linked Agammaglobulinemia: A Case Report and a Reappraisal
Saudi J Kidney Dis Transpl. 2023 Nov 1;34(6):660-665. doi: 10.4103/sjkdt.sjkdt_133_23. Epub 2024 May 9.ABSTRACTIn 1952, X-linked agammaglobulinemia (XLA) was discovered as a rare inherited disorder. It markedly compromises the ability of the body to combat infectious microorganisms. Membranoproliferative glomerulonephritis (MPGN) Type I is characterized by subendothelial immune complex deposits. Patients with XLA can rarely develop immune-complex-induced diseases. Here, we report a case of MPGN Type I in a 12-year-old male patient with a past and family history of XLA. The patient presented with fever, productive cough, vo...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Mahmoud Rezk Abdelwahed Hussein Mashair Babiker Sadaf Asim Mohmmed Elsamwal Source Type: research
Practice Patterns and Approach to Childhood Lupus Nephritis in Saudi Arabia
This study aimed to explore the current practices of pediatric rheumatologists and nephrologists for the diagnosis, management, and monitoring of lupus nephritis (LN) in Saudi Arabia through a survey. Among the 61 respondents, 54.1% were pediatric nephrologists and 49.9% were pediatric rheumatologists. Predominantly, the participating physicians received training either nationally (57%) or in North America (45%). Most of the respondents (77%) did not have a combined rheumatology-nephrology clinic, primarily because of space or time limitations (75%), or a lack of the other specialty (13%). In terms of the decision to reque...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Abdulaziz AlMutairi Sulaiman M Al-Mayouf Jameela Kari Emtenan Basahl Mohammed Nashawi Source Type: research
A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study
This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (&...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aditya Mahaseth Bishnu Pahari Madhav Ghimire Sushil Rayamajhi Source Type: research
Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria
This study aimed to assess the role of lisinopril, an ACE inhibitor, in reducing proteinuria in SCA patients. Thirty-five patients older than 15 years with known SCA (HbSS or HbS-β0) and a 24-h urinary protein level of 150 mg or more participated in this study. Urine was collected over 24 h to quantify proteinuria. The patients had a mean age of 28.5 ± 6.98 years. The median 24-h urinary protein before treatment was 0.3006 g and that after treatment was 0.150 g (P = 0.01). After a median follow-up of 38 months, 24-h urinary protein decreased in 27 (77%) patients and normalized in 18 (52%) patients. Urinary protein increa...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aamer Aleem Abdulrahman Al-Sultan Abdulkareem Alsuwaida Khalid Alsaleh Farjah Algahtani Abdulkareem Almomen Mohammad Sharif Ghazi S Alotaibi Source Type: research
Camrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study
ConclusionCamrelizumab plus famitinib demonstrated favorable benefits in PFS and OS, along with manageable safety profiles, in patients with advanced NSCLC who progressed after platinum-doublet chemotherapy and immunotherapy. This finding warrants further exploration. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - May 10, 2024 Category: Cancer & Oncology Source Type: research
Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series
ConclusionOur findings highlight the rare co-occurrence of Fanconi syndrome and cryoglobulinemia in clinical practice. Despite the lack of causal evidence, the coexistence of Fanconi syndrome and tubulointerstitial injury is also noteworthy in patients with cryoglobulinemia, underscoring the importance of thorough evaluation and tailored management in patients presenting with overlapping renal manifestations.Key Points• Patients with mixed cryoglobulinemia can clinically present with tubulointerstitial injury, specifically manifesting as Fanconi syndrome.• In addition to typical symptoms of Fanconi syndrome, these pati...
Source: Clinical Rheumatology - May 10, 2024 Category: Rheumatology Source Type: research
Evaluation of an algorithm based on quantitative assays of glomerular parameters (albuminuria and urinary IgG) for proteinuria typing
Ann Biol Clin (Paris). 2024 Apr 1;82(2):201-213. doi: 10.1684/abc.2024.1887. Online ahead of print.ABSTRACTThe first orientation test for proteinuria typing is electrophoresis. However, this technique has several drawbacks, such as delayed turnaround time and subjective readings. Some laboratories therefore use quantitative assays of glomerular markers combined with tubular markers. However, the cost of reagents and the instability of certain markers are significant drawbacks for some peripheral laboratories. The aim of this study is to evaluate the implementation of an algorithm based on parameters that can be used by all...
Source: Annales de Biologie Clinique - May 9, 2024 Category: Biochemistry Authors: Ihsane Benlyamani Nathalie Rousseau Christine Lombard Emmanuel Villar Matthieu Pecquet Source Type: research
