Effect of interleukin-1 antagonists on the quality of life in familial Mediterranean fever patients
AbstractBackgroundFamilial Mediterranean fever (FMF) patients suffer from chronic complications of disease such as AA amyloidosis, chronic arthritis, and spondylitis. Reduced quality of life (QoL) is a feature of chronic diseases but it is also impaired in patients with FMF. Despite the regular use of colchicine at a maximal dose, about 10% of patients do not respond well or resistant to colchicine (crFMF). IL-1 inhibitors have been shown to be effective in controlling attacks in crFMF patients. Herein, we aimed to investigate QoL changes of crFMF patients with IL-1 inhibitors.MethodsAll patients were prospectively monitor...
Source: Clinical Rheumatology - December 10, 2018 Category: Rheumatology Source Type: research

Macrophage activation syndrome in a patient with axial spondyloarthritis on adalimumab
We describe a case of a patient with axial spondyloarthritis (axSpA) treated with adalimumab, who presented with MAS. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry
ConclusionsPrevalence of PAH was lower than expected (3.7%). Probability of having elevated esPAP was higher among patients with dSSc and among those with ATA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Risk factors for progression and prognosis of rheumatoid arthritis –associated interstitial lung disease: single center study with a large sample of Chinese population
ConclusionsIn RA-ILD patients, anti-CCP antibody high titer positive and DLCO%
Source: Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Outcome of pregnancy in women with psoriatic arthritis compared to healthy controls
ConclusionsPsA patients do not have more infertility or worse pregnancy outcomes compared to healthy controls. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Steroid-free remission in lupus: myth or reality; an observational study from a tertiary referral centre
AbstractObjectiveWhether maintaining steroid-free remission is feasible in Indian patients with systemic lupus erythematosus (SLE).MethodsIn 148 patients with SLE including 78 lupus nephritis (LN) previously put into remission, steroid therapy was gradually tapered off.ResultsPatients received glucocorticoids for median 1855  days (interquartile range (IQR) 901–2834) before discontinuing. Median duration of follow-up was 539 days (IQR 266.25–840.75). Flare occurred in 31 patients (20.9%; 95% confidence interval (CI) 15.17–28.19, renal flare in 12.16% (18/148, 95% CI 7.83–18.41)). Most of t...
Source: Clinical Rheumatology - December 6, 2018 Category: Rheumatology Source Type: research

A new scoring system to predict Kawasaki disease with coronary artery lesions
ConclusionsThe independent risk factors for acute and subacute KD combined with CAL, including being a boy, long fever duration, IVIGR, low ALB, elevated EO, and MO. Joint of parameters (total fever duration ≥ 8 days, delayed diagnosis, and ALB ≤ 35.9 g/L) can be used to predict the occurrence of CAL in KD patients ≤ 6 months old. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - December 6, 2018 Category: Rheumatology Source Type: research

Dendritic cells in the pathogenesis of ankylosing spondylitis and axial spondyloarthritis
AbstractThe interaction of dendritic cells (DCs) with the human microbiome, with distorted handling of the microbiota or its products via the direct effect of HLA B27, probably represents the initial element in the chain of events leading to the development of clinical axial spondyloarthritis. The mechanism of disease extension onto the skeleton and other tissues involved, such as uvea, may also involve migratory DCs. Finally, the role of DCs in the initiation of the inflammatory tissue response with activation of the IL-17 axis has been demonstrated. Further, some initial data suggests the possible connection of DCs with ...
Source: Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Anti-RNP/Sm antibodies in patients with systemic lupus erythematosus and its role in thrombosis: a case-control study
AbstractObjectiveTo validate the association of thrombotic events with positive lupus anticoagulant (LA) and co-presence of anti-RNP/Sm, as well as the diagnostic accuracy of this combination of antibodies for thrombosis.MethodsCase-control study of patients with systemic lupus erythematosus (SLE) who presented thrombosis after SLE diagnosis and controls with SLE without thrombosis. Comorbidities, traditional risk factors, clinical variables, and treatment were evaluated. Antiphospholipid (aPL) and anti-RNP/Sm antibodies were determined.ResultsSixty-three cases and 63 controls were studied, 88% women, median age of 40 &nbs...
Source: Clinical Rheumatology - December 4, 2018 Category: Rheumatology Source Type: research

MicroRNA-132, miR-146a, and miR-155 as potential biomarkers of methotrexate response in patients with rheumatoid arthritis
AbstractIntroductionRheumatoid arthritis (RA) patients have high expression levels of hsa-miR-132-3p, hsa-miR-146a-5p, and hsa-miR-155-5p in peripheral blood. We studied if baseline blood levels of these microRNAs (miRNAs) could predict response to methotrexate (MTX).MethodsRA patients (the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria) with active disease (disease-modifying anti-rheumatic drug (DMARD) –naïve and Disease Activity Score 28 (DAS28)>  3.2) were enrolled. They were treated with MTX by gradually increasing dose up to 25 mg/week. After 4 ...
Source: Clinical Rheumatology - December 3, 2018 Category: Rheumatology Source Type: research

Treating psoriatic arthritis to target: discordance between physicians and patients ’ assessment, non-adherence, and restricted access to drugs precluded therapy escalation in a real-world cohort
This study aimed to analyze factors precluding treatment optimization in a T2T strategy conducted in a real-world cohort of PsA patients. A retrospective cross-sectional study nested in a cohort was conducted. Medical records of patients ≥ 18 years old, fulfilling CASPAR criteria and with at least one visit in the PsA clinic, were reviewed. Demographic data, current medication, and minimal disease activity (MDA) criteria were recorded. Reasons for the non-escalation of therapy in patients who were not classified as MDA were rep orted as absolute and relative frequencies. In the 8-month period, 131 visits (co...
Source: Clinical Rheumatology - December 3, 2018 Category: Rheumatology Source Type: research

Foot functions in ankylosing spondylitis
In this study, foot functions of ankylosing spondylitis (AS) patients were analyzed with clinical and radiological features.MethodSixty-two AS patients and 39 age-matched, gender-matched, and body mass index (BMI) –matched healthy volunteers were included in this study. Acute-phase reactant levels of participants were recorded. The disease activity and functionality were assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). F oot functional index (FFI) and timed up and go test (TUG) were performed by the same educated nurse. Radiograph...
Source: Clinical Rheumatology - December 3, 2018 Category: Rheumatology Source Type: research

Correction to: the efficacy and safety of total glucosides of peony in the treatment of primary Sj ögren’s syndrome: a multi-center, randomized, double-blinded, placebo-controlled clinical trial
The authors regret that the Fig.  1 in the original version of this article contained an error. In the left column, 211 cases in the TGP group should be followed up for 8 weeks before 12 weeks. The correct figure presented in this article. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - December 3, 2018 Category: Rheumatology Source Type: research

The effect of extra-articular manifestations on tumor necrosis factor- α inhibitor treatment duration in patients with ankylosing spondylitis: nationwide data from the Korean College of Rheumatology BIOlogics (KOBIO) registry
AbstractTumor necrosis factor- α inhibitor (TNFi) therapy has shown to be remarkably effective for treating ankylosing spondylitis (AS); however, nearly 30% of AS patients every year either stop TNFi therapy or switch to a different TNFi due to inefficacy or adverse effects. The goal of this study was to identify predictors of T NFi treatment duration, including extra-articular manifestations, using a nationwide registry in Korea. Data obtained from the Korean College of Rheumatology Biologics (KOBIO) registry, a nationwide, multi-center database representing 58 tertiary care hospitals in Korea. Demographics, clinica...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients
This study investigated the impact of seven polymorphisms in genes of folate transport and (de)glutamation pathway on methotrexate polyglutamate levels and response in patients with rheumatoid arthritis. This prospective study included patients with rheumatoid arthritis. They were treated with methotrexate (up to 25  mg per week) for 24 weeks and categorized by EULAR response criteria into responders (good and moderate) and non-responders. Using real-time Taqman discrimination assay, SNPs were genotyped—rs1045642 (ABCB1 3435C>T), rs1128503 (ABCB1 1236C>T), rs10106 (FPGS 1994A>G), rs1544105 (FPGS G&...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Clinical description of patients with cytoplasmic discrete dots pattern (lysosome) on indirect immunofluorescence on HEp-2 cells
In conclusion, cytoplasmic discrete dot pattern is an uncommon finding and its clinical value is uncertain. However, in our study, 53% of the pat ients had an autoimmune disease. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

International position paper on the appropriate use of uricosurics with the introduction of lesinurad
AbstractOver the last 70  years, pharmacotherapy in gout with urate-lowering drugs has consisted of four drugs only: In 1952, a mild uricosuric probenecid became available, the xanthine oxidase inhibitor Allopurinol in 1964, and the latter became the most frequently used urate-lowering drug worldwide; in the Eurozone, the uricosuric benzbromarone was welcomed in 1977. Only in 2002, the potent non-purine xanthine oxidase inhibitor febuxostat was introduced. In many countries, uricosurics such as probenecid and benzbromarone have not been available up to now, and these days, the new uricosuric lesinurad is the first ur ...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Comparison of the construct validity and reproducibility of four different types of patient-reported outcome measures (PROMs) in patients with rheumatoid arthritis
AbstractPatient-reported outcome measures (PROMs) are increasingly used in the assessment of patients with rheumatoid arthritis (RA). The aim of this study was to assess the construct validity and reproducibility of four types of PROMs (numerical rating scale (NRS), visual analogue scale (VAS), verbal rating scale (VRS), and Likert scale). In addition, patients ’ preference for one of these PROMs was measured. Patients with stable RA and no change in pain medication or steroid medication (n = 211) were asked to complete a questionnaire directly following, and 5 days after their outpatient visit. Th...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members ’ survey 2017
AbstractPolymyalgia rheumatica and giant cell arteritis are relatively common, but under research inflammatory rheumatological conditions. This survey aimed to ascertain the matters in which patients feel they need support with these conditions and appraise how the Charity PMRGCAuk currently supports these needs and could do so in the future. PMRGCAuk members (n = 910) were invited to complete an on-line survey. The survey requested the respondent’s history of PMR and or GCA, their perceived priorities for support for people with PMR and or GCA and views on the services already provided by the Charity. ...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Fibromyalgia and small fiber neuropathy: the plot thickens!
AbstractSeveral groups of investigators have described the presence of small fiber neuropathy in fibromyalgia patients. This writing discusses how this new finding could renovate fibromyalgia concept, diagnosis, and treatment. Predominant rheumatology thinking proposes fibromyalgia as a “centralized pain syndrome.” An alternative hypothesis views fibromyalgia as a stress-related dysautonomia with neuropathic pain features. Dorsal root ganglia may be the key autonomic-nociceptive short-circuit sites. The recent recognition of small fiber neuropathy in a large subgroup of fibromy algia patients reinforces the dys...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Hemodynamic heterogeneity of connective tissue disease patients with borderline mean pulmonary artery pressure and its distinctive characters from those with normal pulmonary artery pressure: a retrospective study
AbstractTo clarify whether patients with connective tissue disease (CTD)-associated borderline mean pulmonary artery pressure (mPAP) have distinctive hemodynamic characteristics from those with normal mPAP and whether pathogenesis is as heterogeneous as manifest pulmonary hypertension (PH). Seventy-five CTD patients who underwent right heart catheterization (RHC) from 2008 through 2016 were retrospectively analyzed. We compared between-group differences in clinical and hemodynamic findings: normal mPAP (n = 35), borderline mPAP (n = 15), and PH (n = 25). A therapeutic intervention ...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

How should we manage low-dose methotrexate-induced pancytopenia in patients with rheumatoid arthritis?
AbstractLow-dose methotrexate (ld-MTX) that is administered during rheumatoid arthritis (RA) treatment has hematological adverse effects such as pancytopenia, although rare. Although well-established and widely used for hematological adverse effects caused by high-dose MTX, leucovorin (folinic acid) treatment does not have an agreed-upon administration for ld-MTX-induced pancytopenia. Here, we aimed to figure out whether there was any difference in response time between the regimens with and without folinic acid prescribed to our patients who developed pancytopenia while on MTX therapy, and to identify risk factors for its...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Foot function in rheumatoid arthritis patients: a cross-sectional study
AbstractRheumatoid arthritis (RA) is a chronic disease that affects mainly small joints from hands and feet. The aims of this study were to analyze the prevalence of foot involvement in a sample of Brazilian RA patients and to explore the influence of disease variables such as inflammatory activity, serological, and epidemiological profile in this type of involvement. One hundred RA patients and 100 healthy controls paired for gender, age, and body mass index answered the FFI-BR (Foot Functional Index –Brazilian version) that evaluates foot function. RA patients had epidemiological and clinical data collection upon d...
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Safety of the concomitant use of methotrexate and a prophylactic dose of trimethoprim-sulfamethoxazole
The objective of this study was to investigate risk factors for cytopenia when a prophylactic dose of trimethoprim-sulfamethoxazole (TMP-SMX) was co-administered with methotrexate (MTX). Patients who received MTX with or without a prophylactic dose of TMP-SMX were included. Patients who received a therapeutic dose of TMP-SMX were excluded. The MTX-alone and MTX with TMP-SMX groups (MTX group and MTX + TMP-SMX group, respectively) were matched in a 4:1 ratio according to age, creatinine level, mean corpuscular volume and MTX dose. Cytopenia was defined as a haemoglobin level decrease by>  2 g/dl, platelet count of
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Association of CD26/dipeptidyl peptidase IV mRNA level in peripheral blood mononuclear cells with disease activity and bone erosion in rheumatoid arthritis
This study demonstrated that CD26 mRNA expression in rheumatoid arthritis patients is associated with disease activity and bone erosion, suggesting a potential role for this molecule in the immunopathology of rheumatoid arthritis and bone erosion. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

The potential role of Ets-1 and miR-326 in CD19 + B cells in the pathogenesis of patients with systemic lupus erythematosus
ConclusionsOur results suggest that miR-326 might promote B cells differentiation by targeting Ets-1, a negative regulator of B cells differentiation and therefore participate in the pathogenesis of SLE. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 19, 2018 Category: Rheumatology Source Type: research

Severe necrotizing myositis associated with long term anti-neoplastic efficacy following nivolumab plus ipilimumab combination therapy
We report a case of severe necrotizing myositis which occurred in a patient treated with N + I combination for mCRC MSI-H. A 61-year-old woman was diagnosed with mCRC MSI-H andBRAFV600E mutated with synchronous liver, pleural, and lymph nodes metastases. After she failed to respond to standard chemotherapy (two lines with 5-fluorouracil, oxaliplatin, and irinotecan + bevacizumab), she received in a clinical trial (CheckMate 142), nivolumab 3  mg/kg, and ipilumumab 1 mg/kg every 3 weeks [4]. One week after the second infusion, she developed rapidly extending proximal muscles weakness associated with diffuse e...
Source: Clinical Rheumatology - November 19, 2018 Category: Rheumatology Source Type: research

The frequency of infections in patients with juvenile idiopathic arthritis on biologic agents: 1-year prospective study
AbstractIntroductionThe most effective and concurrently the safest treatment regimen selection is important to provide early control of juvenile idiopathic arthritis (JIA) and to have an acceptable quality of life. The effectivity of biologic agents as well as standard disease-modifying drugs is well documented in treatment of JIA. In spite of their high benefit, these drugs have the risk of serious infections. Herein, we conducted a prospective study to investigate the infectious complications of biologic agents in patients diagnosed with JIA.MethodsPatients on biologic treatment regimen were examined by the pediatric inf...
Source: Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Potential uses of an infodemiology approach for health-care services for rheumatology
ConclusionInfodemiology provides preliminary information that could help in generating hypotheses, assessing health-care interventions, or even in providing patient-centered care. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Association of work instability with fatigue and emotional status in patients with ankylosing spondylitis: comparison with healthy controls
AbstractIntroduction/ObjectiveAnkylosing spondylitis (AS) is usually seen in among younger person of working age and carries a significant economic burden. It was aimed to explore the relation of work instability with fatigue, depression, and anxiety in working AS patients comparing with healthy controls.MethodThis case-control study was conducted on working 61 AS patients and 40 sex-age-matched working healthy controls. The data were collected using Visual analogue scale-pain, Bath AS Disease Activity Index, Bath AS Functional Index, Bath AS Metrology Index in patients; and Beck Depression Inventory, Beck Anxiety Inventor...
Source: Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Optimal care for systemic sclerosis patients: recommendations from a patient-centered and multidisciplinary mixed-method study and working conference
ConclusionIn this mixed-method study, broad-based consensus was achieved and recommendations were developed to improve health care for SSc patients. The approach, recommendations, and challenges summarized in this paper can be of use for health care professionals and other actors involved in patients with rare, chronic, and multisystem conditions. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Utility of neutrophil CD64 and serum TREM-1 in distinguishing bacterial infection from disease flare in SLE and ANCA-associated vasculitis
AbstractBacterial and opportunistic infections are a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis owing to treatment with immunosuppressants. Commonly used laboratory tests are unreliable in differentiating infection from active disease patients. Fc receptor (Fc γR1 or CD64) expression on neutrophils and soluble TREM-1 (triggering receptor expressed on monocytes) are potential biomarkers of bacterial infections. Our aim was to measure the clinical usefulness of quantitative CD64 measurement on neutrophil...
Source: Clinical Rheumatology - November 16, 2018 Category: Rheumatology Source Type: research

A note from the Editor
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 16, 2018 Category: Rheumatology Source Type: research

Sclerostin rather than Dickkopf-1 is associated with mSASSS but not with disease activity score in patients with ankylosing spondylitis
ConclusionIn the present study, the expressions of serum DKK-1 and sclerostin were independent of disease activity. Sclerostin was negatively correlated with the mSASSS, which suggests that sclerostin may be a potential marker indicating the spine ossification process in AS. The specific mechanism remains to be investigated. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 15, 2018 Category: Rheumatology Source Type: research

Correction to: Psoriasis in systemic lupus erythematosus: a single-center experience
Prof. Ari Polachek on of the author of the published version of this article missed to add his second affiliation which is the Department of Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. The new affiliation is now added and presented correctly in this article. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 14, 2018 Category: Rheumatology Source Type: research

Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial
ConclusionsCompared with cyclophosphamide, low-dose leflunomide in combination with prednisone showed both effectiveness and safety in the induction therapy of proliferative lupus nephritis in Chinese patients. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 13, 2018 Category: Rheumatology Source Type: research

Subcutaneous tocilizumab alone or with a csDMARD in rheumatoid arthritis patients: subanalysis of Italian data from a multicenter phase IIIb/IV trial
AbstractTo assess, in a setting close to real life, the efficacy and safety of weekly subcutaneous tocilizumab (TCZ-SC) 162  mg, alone or with a conventional synthetic DMARD (csDMARD), in moderate-to-severe RA patients with inadequate response to DMARDs or anti-TNFα drugs. This national, multicenter, open-label, phase IIIb trial is part of an umbrella study (TOZURA). Patients were treated for 52 weeks followed by 8 w eeks drug-free to evaluate immunogenicity. The primary end point was the Clinical Disease Activity Index (CDAI) change from baseline at weeks 2 and 24. Other efficacy parameters, including...
Source: Clinical Rheumatology - November 12, 2018 Category: Rheumatology Source Type: research

Validation of a new symptom outcome for knee osteoarthritis: the Ambulation Adjusted Score for Knee pain
ConclusionAASK is simple to assess using existing validated questionnaires. AASK performs well in individuals with and without OA and should be considered in clinical trials and observational studies of early knee OA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 12, 2018 Category: Rheumatology Source Type: research

CIGB-814, an altered peptide ligand derived from human heat-shock protein 60, decreases anti-cyclic citrullinated peptides antibodies in patients with rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a chronic T cell-mediated autoimmune disease. Serum autoantibodies against cyclic citrullinated peptides (anti-CCP) are significant markers for diagnosis and prognosis of this disease. Induction of immune tolerance as therapeutic approach for RA constitutes a current research focal point. In this sense, we carried out a phase I clinical trial in RA patients with a new therapeutic candidate (called CIGB-814); which induced mechanisms associated with restoration of peripheral tolerance in preclinical studies. CIGB 814 is an altered peptide ligand (APL), derived from a CD4+ T cell epitope ...
Source: Clinical Rheumatology - November 10, 2018 Category: Rheumatology Source Type: research

Should a patient with rheumatoid arthritis be a kidney donor?
AbstractWe cared for a woman with sero-positive rheumatoid arthritis (RA), in clinical remission on oral methotrexate (MTX) and hydroxychloroquine, who wished to donate a kidney to a brother with end-stage renal disease (ESRD). We could find scant literature about this unusual clinical circumstance, and therefore review pertinent aspects of renal disease in RA, perioperative medical management, maintenance of disease remission, outcomes for RA patients who have donated kidneys, and relevant ethical issues. Renal complications in RA are not uncommon, with as many as 50% of patients at risk of reduced eGFR. This reflects ant...
Source: Clinical Rheumatology - November 8, 2018 Category: Rheumatology Source Type: research

S100A12 and vascular endothelial growth factor can differentiate Blau syndrome and familial Mediterranean fever from systemic juvenile idiopathic arthritis
AbstractObjectivesSystemic juvenile idiopathic arthritis (sJIA) has recently become regarded as one of the autoinflammatory syndromes (AIS). However, other AIS, such as familial Mediterranean fever (FMF) and Blau syndrome, have been initially misdiagnosed as sJIA because of the clinical similarities. Making the correct diagnosis in the early stage of these AIS is desirable. Therefore, we evaluated serum S100A12 and vascular endothelial growth factor (VEGF) levels to determine if they could be biomarkers for differentiating these AIS.MethodSerum S100A12 and VEGF levels were examined in patients with Blau syndrome (n ...
Source: Clinical Rheumatology - November 8, 2018 Category: Rheumatology Source Type: research

Autoantibody and metalloproteinase activity in early arthritis
ConclusionsOur results suggest that a-CEP-1 may help in differentiation between RF( −) RA and UA. a-CEP-1 and a-Sa may be useful while diagnosing EIA. a-CarP may be used in differentiation of RA RF(−) and UA. However, a follow-up study is needed to evaluate the prognostic value of analyzed antibodies. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 7, 2018 Category: Rheumatology Source Type: research

The effect of methotrexate versus other disease-modifying anti-rheumatic drugs on serum drug levels and clinical response in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors
AbstractTo investigate the effect of concomitant conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) with adalimumab or infliximab on maintaining serum drug and clinical outcomes after the first year of treatment in patients with rheumatoid arthritis (RA). Second, to assess the influence of methotrexate (MTX) dose on these outcomes. Ninety-two patients with RA starting infliximab (n = 67) or adalimumab (n = 25) tumor necrosis factor inhibitor (TNFi) with available drug levels and clinical improvement assessment (European League Against Rheumatism [EULAR] response) after 12&n...
Source: Clinical Rheumatology - November 6, 2018 Category: Rheumatology Source Type: research

Letter to editor: New onset/recurrence of inflammatory arthralgia/spondyloarthritis in patients treated with vedolizumab for intestinal bowel disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 5, 2018 Category: Rheumatology Source Type: research

Is knee osteoarthritis related to coffee drinking? A nationwide cross-sectional observational study
AbstractAimsCoffee is one of the most consumed beverages globally, and coffee consumption is increasing. Osteoarthritis (OA), the most common musculoskeletal disease in the elderly, is also becoming more prevalent. Coffee is associated with various diseases, but there has not yet been a study of the relationship between coffee and knee OA. Therefore, we investigated this relationship in elderly Koreans.MethodsData from 2012 to 2013 were collected from the Korea National Health and Nutrition Examination Survey. We included 2302 participants in our study: 897 men and 1405 women. Participants with knee OA were defined as thos...
Source: Clinical Rheumatology - November 5, 2018 Category: Rheumatology Source Type: research

Long-term pulmonary outcomes and mortality in idiopathic inflammatory myopathies associated with interstitial lung disease
ConclusionsCMP 3m, severe infections, delay in diagnosis, heliotrope erythema, and Raynaud ’s phenomenon were identified as factors of poor prognosis in different IIM associated with ILD. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - November 3, 2018 Category: Rheumatology Source Type: research

The relationship between bristol rheumatoid arthritis fatigue scales and disease activity of patients with rheumatoid arthritis
AbstractFatigue is a symptom that affects the 40 –80% of patients with rheumatoid arthritis (RA) and impairs the quality of life. The aim of this study was to assess multidimensional fatigue scales, the Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAF-MDQ) and the Bristol Rheumatoid Arthritis Fatigue Numerical Rating Sca le (BRAF-NRS) and to evaluate their relationship with disease activity in Turkish RA patients. The study included 180 patients with RA. The Disease Activity Score (DAS28), Clinical Disease Activity Index (CDAI), and Simplified Disease Activity Index (SDAI) were used to evalua...
Source: Clinical Rheumatology - October 23, 2018 Category: Rheumatology Source Type: research

Parathyroid hormone is a determinant of serum Dickkopf-1 levels in ankylosing spondylitis
AbstractAvailable studies reported contradictory results about serum levels Dickkopf-1 (DKK1), an inhibitor of Wnt signaling in patients with ankylosing spondylitis (AS). In previous studies, we observed in other conditions that parathyroid hormone (PTH) serum levels were an important determinant of DKK1 serum levels. The aim of the present study was to investigate it in patients with AS. We recruited 71 patients diagnosed with AS. Levels of C-reactive protein (CRP), DKK1, PTH, 25OH-vitamin D, and bone turnover markers (intact N-propeptide of type I collagen, P1NP, and C-terminal telopeptide of type I collagen, CTX) were m...
Source: Clinical Rheumatology - October 23, 2018 Category: Rheumatology Source Type: research

Serum-soluble folate receptor β as a biomarker for the activity of rheumatoid arthritis synovitis and the response to anti-TNF agents
This study aims to develop a sandwich ELISA system for the measurement of soluble folate receptor β (sFRβ) and evaluate whether base line levels of serum sFRβ are a biomarker for the activity of RA synovitis and the response to anti-TNF agents. Serum sFRβ from normal controls (41 samples), patients with OA (29 samples), and patients with RA (27 samples) and synovial fluid sFRβ from patients with RA (17 samples) were measured by sandwich ELISA, using anti-FRαβ and anti-FRβ antibodies as capture and detection antibodies, respectively. Baseline levels of serum sFRβ before therapy ...
Source: Clinical Rheumatology - October 23, 2018 Category: Rheumatology Source Type: research

Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis
AbstractThe cannabinoid (CB) receptor 2, primarily expressed in immune cells, was shown to play important immune-regulatory functions. In particular, the CB2-R63 functional variant has been shown to alter the ability of the CB2 receptor to exert its inhibitory function on T lymphocytes. The aim of this study was to investigate the association between a common dinucleotide polymorphism, Q63R, in the cannabinoid receptor 2 gene (CNR2) and rheumatoid arthritis (RA) in the Lebanese population. One hundred five unrelated Lebanese RA patients and one hundred five controls from different Lebanese governorates were recruited in th...
Source: Clinical Rheumatology - October 23, 2018 Category: Rheumatology Source Type: research