Some days you win
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Study on the expressions of NLRP3 gene transcript variants in peripheral blood monocytes of primary gout patients
This study was undertaken to evaluate whether NLRP3 gene transcript variants are involved in the occurrence of PG. A total of 44 acute phase PG (APPG), 52 non-acute phase PG (NAPPG) male patients, and 30 male health control (HC) were involved in this study. We measured NLRP3 and its transcript variants 2, 3, 4, 5, and 1  + 6 expressions in the PBMCs, together with the level of IL-1β in the serum. Further, PBMCs of HC were stimulated with MSU crystals. The levels of NLRP3, NLRP3 gene transcript variants 2, 3, 4 mRNA, and protein expressions were significantly lower in the APPG and NAPPG groups than in the...
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Aberrant T cell subsets and cytokines expression profile in systemic lupus erythematosus
AbstractTo assess T cell subsets and levels of chemokines and cytokines in patients with SLE and determine their relationships between disease activity and organ involvement. Blood samples from SLE patients (n = 24) and healthy controls (n = 36) were analyzed. Frequency of circulating follicular help T cells (Tfh), central memory T cells (Tcm), effector memory T cells (Tem), and naïve T cell subsets was enumerated and their surface markers expression of inducible T cell co-stimulator (ICOS) and programmed death 1(PD-1) protein w as examined by flow cytometry. The disease state in SLE patien...
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Vasculitis associated with immune checkpoint inhibitors —a systematic review
This study sought to evaluate the occurrence and nature of vasculitis associated with cancer treatment using immune checkpoint inhibition (anti-PD-1, anti-PDL-1, and anti-CTLA4). A systematic review of the medical literature was conducted by searching all available clinical data up to February 2018 in several databases and search engines including Cochrane Library, Embase, Google Scholar, Medline, Scopus, Web of Science, andClinicaltrials.gov. Searches included the following FDA-approved anti-PD1 (nivolumab and pembrolizumab), anti-PDL1 (atezolizumab, avelumab, and durvalumab), and anti-CTLA4 (ipilimumab). The vasculitis c...
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Risk of active tuberculosis in patients with inflammatory arthritis receiving TNF inhibitors: a look beyond the baseline tuberculosis screening protocol
This study aimed to assess the incidence of active TB and the efficacy of TB prevention measures used over the years, and to determine risk factors for developing TB, in a single-centre cohort of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) receiving TNFi. Data of all patients in whom treatment with TNFi was initiated in our rheumatology clinic until December 1st 2014 have been retrospectively analysed. The cohort was divided into 3 groups per the mandatory LTBI screening method at baseline: tuberculin skin test (TST) with a positive threshold of either 10  mm (gro...
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Vitamin D level and risk of systemic lupus erythematosus and rheumatoid arthritis: a Mendelian randomization
AbstractThe aim of this study was to examine whether the vitamin D level is causally associated with risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). We performed two-sample Mendelian randomization (MR) analyses using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods on publicly available summary statistics datasets using two vitamin D level genome-wide association studies (GWASs) as exposure and SLE and RA GWASs on people of European descent as outcomes. We selected three independent single-nucleotide polymorphisms located at SSTR4 (rs2207173), GC (rs2282679), an...
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Correction to: The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink
The above article originally published with an error present in the 2nd sentence in the 4th paragraph of the discussion section and is now presented correctly in this article. The remainder of the article remains unchanged. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - August 15, 2018 Category: Rheumatology Source Type: research

Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women
AbstractOur objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses ’ Health Study (NHS, 1984–2014) and 93,572 women in the NHSII (1991–2013); incident RA was confirmed by medical records. Food frequency questionnaires (FFQ) were completed at baseline and approximately every 4 years. Inflammatory dietary pattern was assessed from FFQ data using the Empirical Dietary Inflammatory Pattern (EDIP), including 18 anti-/pro-inflammatory food/beverage groups weighted by...
Source: Clinical Rheumatology - August 14, 2018 Category: Rheumatology Source Type: research

Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients
AbstractTo compare the efficacy of adalimumab (ADA) and infliximab (IFX) in patients with non-infectious intermediate uveitis, posterior uveitis, and panuveitis. Demographic, clinical, instrumental, and therapeutic data from patients enrolled were collected at the start of treatment, at 12-month follow-up, and at the last follow-up assessment. One hundred seven patients (46 females, 187 eyes) were enrolled, 66 (61.7%) treated with ADA and 41 (38.3%) with IFX. Bilateral involvement was observed in 80 cases. The mean follow-up was 26.45  ± 21.71 months for ADA patients and 56.60 ±&thin...
Source: Clinical Rheumatology - August 11, 2018 Category: Rheumatology Source Type: research

Added value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome: lessons learned from year-long routine measurements
AbstractThe international classification criteria for definite antiphospholipid syndrome (APS) include three laboratory measurements: lupus anticoagulant (LA), IgG and IgM isotypes of anti-cardiolipin (aCL) and anti- β2glycoprotein I antibodies (anti-β2GPI). When persistently elevated, they are specific for APS; however, many patients that fulfil clinical criteria may exhibit negative serological results. These “seronegative” APS (SN-APS) are exposed to an increased thrombotic risk. The aims of our cross-s ectional, retrospective study of consecutive autoimmune patients’ samples were to evaluate...
Source: Clinical Rheumatology - August 11, 2018 Category: Rheumatology Source Type: research

Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines
The objective of this paper is to report on the recommendations for the management of patients with RA in the Eastern Mediterranean region. We adapted the 2015 American College of Rheumatology guidelines in two separate waves. We used the adolopment methodology, and followed the 18 steps of the “Guidelines 2.0” comprehensive checklist for guideline development. For each question, we updated the original guidelines’ evidence synthesis, and we developed an Evidence Profile (EP) and an Evidence to Decision (EtD) table. In the first wave, we adoloped eight out of the 15 original question s on early RA. The st...
Source: Clinical Rheumatology - August 10, 2018 Category: Rheumatology Source Type: research

Angiotensin II type 1 receptor gene polymorphism and serum angiotensin-converting enzyme level in Egyptian children with systemic lupus erythematosus
AbstractAngiotensin II, the major effective molecule of the renin-angiotensin system, plays a vital role in the development of systemic lupus erythematosus (SLE). To study angiotensin II type 1 receptor (AT1R) gene polymorphism at (A1166C) in Egyptian children with SLE and its correlation with serum ACE level and SLE manifestations. AT1R gene polymorphism (A1166C) was done in 123 children with SLE in comparison to 100 healthy controls using polymerase chain reaction-based restriction fragment length polymorphism method (PCR-RFLP) and the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARM...
Source: Clinical Rheumatology - August 9, 2018 Category: Rheumatology Source Type: research

Non-albumin proteinuria as a parameter of tubulointerstitial inflammation in lupus nephritis
AbstractTubulointerstitial inflammation (TI) has prognostic significance in the renal outcomes of lupus nephritis. Here, we aimed to determine whether non-albumin proteinuria is associated with TI severity and with the renal response in lupus nephritis. We included patients with biopsy-confirmed lupus nephritis at a tertiary medical center in Korea from January 2011 to April 2017. Patients in whom the urine protein/creatinine ratio (uPCR) and the urine albumin/creatinine ratio (uACR) were measured simultaneously were included. Laboratory data and renal pathology were reviewed. Non-albumin proteinuria was calculated by subt...
Source: Clinical Rheumatology - August 9, 2018 Category: Rheumatology Source Type: research

Epidemiology and management practices for childhood-onset systemic lupus erythematosus patients: a survey in Latin America
AbstractTo assess epidemiology and management practices of Latin America Pediatric Rheumatologists (LAPR) about childhood-onset systemic lupus erythematosus (cSLE). A cross-sectional study was performed in 288 LAPR PANLAR members based on online survey about cSLE practices. The response rate of web-based survey by LAPR was 170/288(59%) and the majority worked in university hospitals (63%). The ACR and/or SLICC classification criteria (99%) and disease activity tools (97%) were almost universally used by LAPR, whereas damage index (70%) and CHAQ (58%) instruments were less frequently used. Laboratory exams, diagnostic imagi...
Source: Clinical Rheumatology - August 9, 2018 Category: Rheumatology Source Type: research

Prevalence, severity, and predictors of dry eye and dry mouth in Chinese patients with primary Sj ögren syndrome
This study aimed to investigate the prevalence, severity, and potential predictors of dry eye/dry mouth among Chinese pSS patients. A cross-sectional study was conducted from the Affiliated Hospital of Nantong University. A series of questionnaires were applied: Ocular Surface Disease Index (OSDI), EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI)-dry mouth items, fatigue severity scale (FSS), the 10 cm visual analog scale (VAS). Laboratory examinations were taken to obtain some bioch emical indicators (i.e., C-reactive protein, erythrocyte sedimentation rate, anti-SSA/SSB antibody). Stepwise logistic/lin...
Source: Clinical Rheumatology - August 9, 2018 Category: Rheumatology Source Type: research

Development of a questionnaire survey to evaluate lower limb function of patients with knee osteoarthritis
This study aimed to develop a self-questionnaire index relevant to lower limb functional assessment reflecting clinical symptoms and activity restrictions associated with activities of daily living (ADL) for patients with knee osteoarthritis. This cross-sectional study enrolled patients with knee osteoarthritis (Kellgren/Lawrence grade  ≥ 1). Participants evaluated clinical symptoms and activity restrictions using self-reported questionnaires. Radiographic evaluation, knee joint range of motion (ROM), and lower limb muscle strength were assessed. Associations between clinical symptoms, activity restriction...
Source: Clinical Rheumatology - August 8, 2018 Category: Rheumatology Source Type: research

Risk of total knee arthroplasty in young and middle-aged adults with ankylosing spondylitis
The objective was to determine the risk of primary total knee arthroplasty (TKA) in young and middle-aged adults with ankylosing spondylitis (AS). We computed arthroplasty rates among US Medicaid recipients age 18 to 64 with AS and a comparison group without AS from 1999 to 2011. Among 14,714 patients with AS and 2,932,641 patients without AS, rates of primary TKA were 1.82-fold higher (95% confidence interval 1.57, 2.10) among patients with AS. The risk of primary TKA is elevated in young and middle-aged adults with AS. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - August 7, 2018 Category: Rheumatology Source Type: research

Stroke and antiphospholipid syndrome —antiphospholipid antibodies are a risk factor for an ischemic cerebrovascular event
AbstractTesting for antiphospholipid antibodies could be an important part in determining the cause of a cerebrovascular event (CVE). Currently, it is also unknown whether antiphospholipid antibodies represent a risk factor for the development of a CVE and whether the selected therapy options are efficacious. So, this study aimed at (1) determining the frequency of patients experiencing a CVE and fulfilling the laboratory criterion for an antiphospholipid syndrome (APS), (2) investigating whether the persistent presence of antiphospholipid antibodies represented a risk factor for a CVE, and (3) focusing on the efficacy of ...
Source: Clinical Rheumatology - August 7, 2018 Category: Rheumatology Source Type: research

MicroRNA expression in the affected skin of adult patients with IgA vasculitis
AbstractIgA vasculitis (IgAV) represents a common systemic vasculitis in pediatric and adult population. Our current knowledge of disease pathogenesis is still very limited, without information on miRNAs in IgAV. The aim of our study was to determine the expression of five pre-selected miRNAs (miRNA-146a-5p, miRNA-148-3p, miRNA-155-5p, miRNA-223-3p, and let-7b) in the affected skin of adult IgAV patients. The study included 65 skin samples from consecutive, untreated IgAV patients (61.5% male, median age 67.6  years, range 29–91), diagnosed between October 2014 and September 2016, and 20 samples of normal skin f...
Source: Clinical Rheumatology - August 6, 2018 Category: Rheumatology Source Type: research

Does leflunomide have a role in giant cell arteritis? An open-label study
AbstractGlucocorticoid monotherapy has been the mainstay treatment of giant cell arteritis (GCA) for decades. We aimed to evaluate the role of leflunomide as a steroid-sparing agent in GCA. This open-label study included incipient GCA patients followed for at least 48  weeks at a single secondary/tertiary rheumatology centre. At the time of diagnosis, patients received glucocorticoids. At week 12 of follow-up, leflunomide 10 mg qd was recommended as an adjunctive therapy to all patients without contraindications. The decision to start the leflunomide was patien t-dependent. The number of relapses, a cumulative gl...
Source: Clinical Rheumatology - August 6, 2018 Category: Rheumatology Source Type: research

Goals of gout treatment: a patient perspective
AbstractTo assess the goals of gout treatment from a patient perspective, a convenience sample of consecutive patients with doctor-diagnosed gout seen at a community-based outpatient clinic were invited. Sex-stratified nominal groups were conducted until saturation was achieved. Responses were collected verbatim, discussed, and rank-ordered by each participant. Thirty-six patients with doctor-diagnosed gout participated in 12 nominal groups: 6 male only, 5 female only, and 1 group with both. Mean age was 61.9  years (SD, 12.3); mean gout duration was 13.3 years (SD, 12.5); 53% were men, 64% African-American, 42% ...
Source: Clinical Rheumatology - August 4, 2018 Category: Rheumatology Source Type: research

Structural damage progression in patients with early rheumatoid arthritis treated with methotrexate, baricitinib, or baricitinib plus methotrexate based on clinical response in the phase 3 RA-BEGIN study
In conclusion, patients achieving versus not achieving sustained DAS28-hsCRP ≤ 3.2 or SDAI score ≤ 11 were less likely to show structural damage progression, irr espective of treatment. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - August 4, 2018 Category: Rheumatology Source Type: research

Preventive effect of tumor necrosis factor inhibitors versus nonsteroidal anti-inflammatory drugs on uveitis in patients with ankylosing spondylitis
AbstractTo compare the preventive effect of tumor necrosis factor (TNF) inhibitors (anti-TNF antibody and soluble TNF receptor fusion protein (TNFR)) and nonsteroidal anti-inflammatory drugs (NSAIDs) on uveitis in patients with ankylosing spondylitis (AS). This retrospective cohort study included all AS patients (n = 1055) who have been treated with either TNF inhibitor or NSAIDs at the Seoul National University Hospital from 2004 to 2016. Treatment episodes of each patient were assigned to anti-TNF antibody (n = 517), TNFR (n = 341), and NSAID (n = 704) groups. The i...
Source: Clinical Rheumatology - August 4, 2018 Category: Rheumatology Source Type: research

Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis
This study examined whether coffee consumption is causally associated with osteoarthritis. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) and weighted median estimates, and the MR-Egger regression method were performed. The publicly available summary statistical datasets of coffee consumption genome-wide association studies (GWASs) meta-analyses on coffee intake from eight Caucasian cohorts (n = 18,176), GWAS meta-analyses of predominately regular-type coffee consumers of European ancestry (n = up to 91,462), and a GWAS in 7410 patients with osteoarthritis in the arcO...
Source: Clinical Rheumatology - August 3, 2018 Category: Rheumatology Source Type: research

The incidence of idiopathic inflammatory myopathies in the adult Slovenian population
AbstractIdiopathic Inflammatory myopathies (IIM) are rare disorders. The aim of our study was to determine the incidence of IIM in a well-defined Slovenian region. This retrospective study was conducted at the Department of Rheumatology, University Medical Centre Ljubljana, the only secondary/tertiary rheumatology center in a region with a population of 704,342 adults. We identified potential IIM cases by searching the electronic patient records for ICD-10 codes M33, M35.1, M35.8, M60, G72, G73, and J84. We included incipient IIM cases between January 2010 and December 2017, who were at the time of the diagnosis, residents...
Source: Clinical Rheumatology - August 2, 2018 Category: Rheumatology Source Type: research

Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis
AbstractImmunoglobulin A vasculitis (IgAV) is an immune complex, small vessel vasculitis with dominant IgA deposits in vessel walls, predominantly affecting the pediatric population. However, adults frequently have more severe gastrointestinal tract (GIT) and renal involvements as compared to children. Our aim was to study serological and cellular biomarkers to support clinicians in their diagnosis and the course of IgAV in adult patients. This cross-sectional study included 62 adult IgAV patients and 53 healthy blood donors (HBDs). Demographic and clinical data, as well as routine laboratory tests, were meticulously analy...
Source: Clinical Rheumatology - August 2, 2018 Category: Rheumatology Source Type: research

Antiphospholipid antibodies in adult IgA vasculitis: observational study
AbstractWe evaluated the occurrence of antiphospholipid antibodies (aPLs) in acute adult IgA vasculitis (IgAV), and potential correlations with IgAV clinical presentation. We determined lupus anticoagulants (LAs) and IgG, IgM, and IgA isotypes of anticardiolipin antibodies (aCL), antibodies against β2-glycoprotein I (aβ2GPI) and against the phosphatidylserine-prothrombin complex (aPS/PT) in prospectively collected, histologically proven IgAV, diagnosed for the first time between January 2013 and February 2018 at our secondary/tertiary rheumatology center. During the 62 months, we determined aPLs in 125 IgAV ...
Source: Clinical Rheumatology - August 2, 2018 Category: Rheumatology Source Type: research

The incidence rate and the early management of rheumatoid arthritis in Slovenia
AbstractEpidemiological data for rheumatoid arthritis (RA) differ according to ethnicity and geographical region. Moreover, despite of clear RA management guidelines, the implementation of treat-to-target (T2T) strategy often remains incomplete. Our objectives were to determine the incidence rate of RA, the clinical characteristics, and the level of adherence to the T2T guidelines in Slovenia. We analyzed prospectively the collected data of adult patients diagnosed with RA from 2014 through 2016 at the Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia. The department provides rheumatology...
Source: Clinical Rheumatology - August 2, 2018 Category: Rheumatology Source Type: research

Systemic sclerosis-rheumatoid arthritis overlap syndrome complicated with Sweet ’s syndrome
AbstractHerein, we report a case of a 34-year-old woman with systemic sclerosis (SSc)-rheumatoid arthritis (RA) overlap syndrome (OS) complicated with Sweet ’s syndrome. OS has been defined as entities satisfying classification criteria of at least two connective tissue diseases (CTD) occurring at the same or at different times in the same patient. The CTD include RA, SSc, systemic lupus erythematosus (SLE), polymyositis, and dermatomyositis. Sweet’ s syndrome also known as acute febrile neutrophilic dermatosis was first described by Robert Sweet in 1964. Sweet’s syndrome is characterized by fever, neutro...
Source: Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink
AbstractTo estimate the incidence, prevalence, and survival of systemic sclerosis in the United Kingdom. We conducted a historical cohort study using data from the Clinical Practice Research Datalink (CPRD). We calculated the incidence and survival of systemic sclerosis between 1994 and 2013 and examined its association with age, sex, and socioeconomic status. We calculated point prevalence on 1 July 2013 and examined its association with the same exposures. We identified 1327 cases with incident systemic sclerosis. Annual incidence was 19.4 per million person-years between 1994 and 2013. The incidence was 4.7 times higher...
Source: Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Differences in daily objective physical activity and sedentary time between women with self-reported fibromyalgia and controls: results from the Canadian health measures survey
AbstractPhysical activity and sedentary behaviors are important modifiable factors that influence health and quality of life in women with fibromyalgia. The purpose of this study was to compare objectively assessed physical activity and sedentary time in women self-reporting fibromyalgia with a control group. Data were drawn from the Canadian Health Measures Survey cycles 1, 2, and 3 conducted by Statistics Canada. We included women aged 18 to 79  years with complete accelerometer data. We performed one-way analyses of covariance (adjusted-for socio-demographic and health factors) to determine mean differences in phys...
Source: Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real-life clinical practice: a nationwide multicenter retrospective observational study
AbstractA few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting. Demographic, clinical, and therapeutic data from patients treated with ANA and CAN were retrospectively collected and analyzed. Four hundred and seventy five patients were enrolled; ANA and CAN were prescribed in 421 and 105 treatment courses, respectively. During a mean follow-up of 24.39  ± 27.04 months, 89 adverse events (AE) were recorded; 13 ...
Source: Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Correction to: First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study
When first published, this article inadvertently listed the RESCLE investigators individually within the author list. The names should instead have been listed within the Acknowledgements section only. The corrected author list and the updated Acknowledgements section are presented in this Correction. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Intravenous cyclophosphamide pulse therapy in interstitial lung disease associated with systemic sclerosis in a retrospective open-label study: influence of the extent of inflammation on pulmonary function
AbstractInterstitial lung disease (ILD) is the primary cause of death in patients with systemic sclerosis (SSc). It is thought that chronic inflammation is a key component in SSc-ILD. Treatment, such as cyclophosphamide (CYC), targets this inflammation. We hypothesized that treatment with CYC might be more effective in the inflammatory phase. Therefore, we analyzed whether the extent of inflammation, as assessed by the proportion of ground glass compared to fibrosis, SSc disease duration, the extent of ILD, or baseline diffusion capacity of the lungs (DLCO)  0.05). Forty-four patients completed 12 cycles of CYC. For...
Source: Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Clinical characteristics and risk factors of infections in patients with systemic lupus erythematosus
AbstractTo investigate the clinical characteristics of infection in SLE patients and analyze the risk factors of infection. A retrospective analysis method was used and the data were collected from 173 case times of 142 hospitalized patients. We found the incidence rate of infections in SLE was 50.7%. The most common infection sites were lungs, followed by upper respiratory tracts and urinary tracts. The most common pathogens were bacteria, followed by fungi. The infection-associated risk factors were duration of hospitalization, lupus activity state, the use of high-dose corticosteroids and immunosuppressive agents, the l...
Source: Clinical Rheumatology - July 9, 2018 Category: Rheumatology Source Type: research

Development and effect of antibodies to anakinra during treatment of severe CAPS: sub-analysis of a long-term safety and efficacy study
AbstractAnakinra is an effective, well-tolerated, long-term anti-inflammatory treatment for cryopyrin-associated periodic syndromes (CAPS), yet evidence shows that it can induce the development of anti-drug antibodies (ADA). This analysis aims to determine ADA occurrence in CAPS patients and elucidate their effects on anakinra dosing and drug efficacy. A post hoc analysis was performed on data from a long-term safety and efficacy study in patients with severe CAPS. Patients were initiated on an anakinra dose of 1.0 –2.4 mg/kg once daily subcutaneously, which was increased (in 0.5–1.0 mg/kg increments)...
Source: Clinical Rheumatology - July 7, 2018 Category: Rheumatology Source Type: research

Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in Beh çet’s disease: which and when to use?
In this study, we investigated NLR and PLR in patients with BD as a marker of disease activity and its association with different clinical manifestations. The study included 23 BD patients; their mean age was (32.5 ± 6.76) and M:F ratio was 16:7. Complete blood picture was done for all patients. NLR and PLR were compared in both active and inactive BD patients and its relation w ith different clinical manifestations was assessed. NLR was higher in active BD patients than in inactive BD patients (P   0.05). Both ratios were not affected by the presence of neurologic deficits nor previous v...
Source: Clinical Rheumatology - July 7, 2018 Category: Rheumatology Source Type: research

Diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus: a meta-analysis
AbstractTo systematically evaluate the diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus (SLE). Studies were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and China Biology Medicine (CBM) disc database, and languages were limited in English and Chinese. QUADAS-2 tool was applied to assess the quality of eligible studies. Random-effect model was applied to calculate pooled effects of miRNAs on diagnosing SLE. Subgroup analysis was used to explore the sources of heterogeneity. All data were calculated and analyzed by Meta-Disc 1.4 and RevMan 5.3 softw...
Source: Clinical Rheumatology - July 6, 2018 Category: Rheumatology Source Type: research

An epidemiological study of the prevalence rate of inflammatory back pain and axial spondyloarthritis in a university in the south of China
AbstractInflammatory back pain (IBP) is an important clinical feature for axial spondyloarthritis (SpA). Yet, little is known about their prevalences in China. We conducted an epidemiological study in a university to detect the prevalences of IBP and axial SpA according to the Assessment of SpondyloArthritis International Society (ASAS) criteria. We investigated 3770 participants from South China Agricultural University by face-to-face questionnaires and evaluated the prevalences of chronic low back pain (CLBP) and IBP. In addition, 333 students including all IBP patients volunteered to do HLA-B27 test, and we performed X-...
Source: Clinical Rheumatology - July 4, 2018 Category: Rheumatology Source Type: research

Oral cyclophosphamide in treatment of patients with refractory idiopathic inflammatory myopathies: a retrospective observational study
We report the first cohort study of PO CYC use in IIM patients with severe , treatment refractory disease. Further trials are needed to verify these results as well as to evaluate long-term safety outcomes. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 3, 2018 Category: Rheumatology Source Type: research

Women who had appendectomy have increased risk of systemic lupus erythematosus: a nationwide cohort study
AbstractThe appendix is involved in immune function, and an appendectomy may alter the immune system. Studies evaluating the relationship between previous appendectomy and the risk of systemic lupus erythematosus (SLE) are lacking. This nationwide cohort study investigated the incidence and risk of SLE in patients who underwent appendectomy. Patients aged>  20 years who received appendectomy from 2000 to 2011 were identified from the National Health Insurance Research Database and assigned to the appendectomy cohort. Patients without appendectomy were randomly selected from the NHIRD and assigned to the cont...
Source: Clinical Rheumatology - July 3, 2018 Category: Rheumatology Source Type: research

Prevalence and factors associated with disturbed sleep in outpatients with ankylosing spondylitis
AbstractSleep disturbance is prevalent among patients with ankylosing spondylitis (AS) and is considered a multifactorial issue. The study was designed to investigate sleep disturbance and its associated factors in AS outpatients in Southwest China. Patients were recruited by convenience sampling in this cross-sectional study. The Pittsburgh Sleep Quality Index (PSQI), the Bath AS Disease Activity Index (BASDAI), the Bath AS Functional Index (BASFI), the Bath AS Patient Global Score (BAS-G), and the Hospital Anxiety and Depression Scale (HADS) were used to assess sleep quality, disease activity, function status, global wel...
Source: Clinical Rheumatology - July 3, 2018 Category: Rheumatology Source Type: research

The impact of hypermobility spectrum disorders on musculoskeletal tissue stiffness: an exploration using strain elastography
AbstractHypermobility spectrum disorders (HSDs) are conditions associated with chronic joint pain and laxity. HSD ’s diagnostic approach is highly subjective, its validity is not well studied, and it does not consider many of the most commonly affected joints. Strain elastography (SEL) reflects musculoskeletal elasticity with sonographic images. The study explored the impact of HSD on musculoskeletal elastici ty using SEL. A cross-sectional design compared 21 participants with HSD against 22 controls. SEL was used to assess the elasticity of the deltoid, biceps brachii, brachioradialis, rectus femoris, and gastrocnem...
Source: Clinical Rheumatology - July 3, 2018 Category: Rheumatology Source Type: research

Correction to: Late-onset Pneumocystis jirovecii pneumonia (PJP) in patients with ANCA-associated vasculitis
The family name of the corresponding author on this article was incorrectly spelled as “El Hakem Matraiah”. The correct spelling should have been “El Hakem Metraiah”. This is now presented correctly in this article. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 3, 2018 Category: Rheumatology Source Type: research

The best cardiovascular risk calculator to predict carotid plaques in rheumatoid arthritis patients
AbstractAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in patients with rheumatoid arthritis (RA). Chronic inflammation and traditional risk factors increase cardiovascular risk (CVR) in these patients. Several CVR calculators are used in general population and in RA patients to predict cardiovascular outcomes and tailor therapy but the precision of these calculators in RA patients has yet to be determined. The aim of this study is to determine which risk calculator correlates best with carotid ultrasound (US) findings, specifically carotid plaque (CP) and carotid intima-media thickness (CIMT)...
Source: Clinical Rheumatology - July 2, 2018 Category: Rheumatology Source Type: research

Rituximab for refractory rapidly progressive interstitial lung disease related to anti-MDA5 antibody-positive amyopathic dermatomyositis
AbstractTo report our experience in using rituximab (RTX) for treating refractory rapidly progressive interstitial lung disease (RP-ILD) complicating anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab)-positive amyopathic dermatomyositis (ADM). Medical records of four ADM patients with refractory RP-ILD treated with RTX therapy were reviewed retrospectively. All four patients were tested positive for anti-MDA5 Ab and failed to respond to high-dose systemic steroid and other intensive immunosuppressive therapies. Respiratory symptoms, lung function tests, and high-resolution computed tomography (HRCT) of...
Source: Clinical Rheumatology - June 18, 2018 Category: Rheumatology Source Type: research

Brief communication: use of the minimal important difference for a meta-analysis on exercise and anxiety in adults with arthritis
The objective of this study was to use the more recently developed and clinically relevant minimal important difference (MID) approach to examine this association. Data from a previous meta-analysis of 14 randomized controlled trials representing 926 initially enrolled adults ≥ 18 years of age (539 exercise, 387 control) was used to calculate the ES using the MID approach. Minimal important difference data were derived from previously reported anchor-based values that represented the different instruments used to assess anxiety. Effect sizes were pooled using the in verse heterogeneity (IVhet) model. Overall...
Source: Clinical Rheumatology - June 18, 2018 Category: Rheumatology Source Type: research

Correction to: Regional differences in baseline disease activity and remission rates following golimumab treatment for RA: results from the GO-MORE trial
The original publication contains two areas which require correcting. None of these errors change the results or conclusions of the article, but the authors wish to highlight the areas of change to the reader. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - June 18, 2018 Category: Rheumatology Source Type: research

Advances in the diagnosis and treatment of Sjogren ’s syndrome
This article reviews the recent classification criteria for primary SS and briefly discusses the conventional and novel therapies of the disease. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - June 18, 2018 Category: Rheumatology Source Type: research

Late-onset Pneumocystis jirovecii pneumonia (PJP) in patients with ANCA-associated vasculitis
AbstractImmunosuppression in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is complicated by increasing risk of infections including opportunistic infections like Pneumocystis jirovecii pneumonia (PJP). Available evidence on risk factors and indications for prophylaxis in AAV is derived from PJP occurring early in the course of AAV. In this retrospective study, we characterized the profile of PJP in patients with AAV. PJP cases were identified retrospectively based on positive polymerase chain reaction test from electronic record followed by confirmation from medical records over a 10-year period....
Source: Clinical Rheumatology - June 18, 2018 Category: Rheumatology Source Type: research