Anti-mitochondrial autoantibodies are associated with cardiomyopathy, dysphagia, and features of more severe disease in adult-onset myositis
AbstractWe analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences in myositis patients with AMA. We screened sera from myositis patients including 619 adult- and 371 juvenile-onset dermatomyositis (DM, JDM), polymyositis (PM, JPM), inclusion body myositis (IBM), or amyopathic DM patients and from healthy controls, including 164 adults and 92 children, for AMA by ELISA. Clinical characteristics were compared between myositis patients with and without AMA. AMA were present in 5% of adult myositis patients (16 of 216...
Source: Clinical Rheumatology - April 13, 2021 Category: Rheumatology Source Type: research

Metabolic syndrome and adipokine levels in systemic lupus erythematosus and systemic sclerosis
AbstractIntroductionAims of study were to evaluate the prevalence of metabolic syndrome (MetS) in systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) patients and to evaluate serum level of adipokines in SLE and SSc patients with and without MetS.MethodsFifty SLE patients and 85 SSc patients were enrolled. The diagnosis of MetS was made according to the criteria of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III. Clinical assessment and serum levels of adiponectin and resistin were evaluate in SLE and SSc patients.ResultsPrevalence of MetS was significantly (p
Source: Clinical Rheumatology - April 11, 2021 Category: Rheumatology Source Type: research

HADS-depression score is a mediator for illness perception and daily life impairment in Takayasu ’s arteritis
AbstractIntroduction/objectivesThe aim of this study was to evaluate the relationships among the disease activity, illness perception, daily life performance, anxiety and depression status as potential mediators in Takayasu ’s arteritis (TAK) patients.MethodIn this cross-sectional study, 77 TAK patients were included. Data were collected by a clinical examination and a structured questionnaire regarding patient reported outcome measures (PROMs). Indian Takayasu ’s Arteritis Activity Score2010 (ITAS2010) was used to assess the disease activity (0: inactive vs ≥ 1: active). Illness Perception Questionnaire-Rev...
Source: Clinical Rheumatology - April 11, 2021 Category: Rheumatology Source Type: research

Adverse pregnancy outcomes in women with Beh çet’s disease: population-based registry linkage study in Taiwan
ConclusionsPatients with BD have no significant risks of multiple complications except for puerperal cerebrovascular disease and gestational diabetes during pregnancy. Close monitoring of blood sugar is suggested. Furthermore, neonatal outcomes were not influenced by BD.Key Points•Patients with Beh çet’s disease are at a risk of puerperal cerebrovascular disease and gestational diabetes during pregnancy.•The odds ratio and 95% confidence interval for puerperal cerebrovascular disorders were 12.08 (1.7 –85.9), and those for gestational diabetes were 1.89 (1.1–3.25).•Pregnant patients ...
Source: Clinical Rheumatology - April 9, 2021 Category: Rheumatology Source Type: research

Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment
We present a patient with methotrexate (MTX)-resistant treatment POPP, who had significant resolution of symptoms and inflammatory lesions on post-treatment MRI with secukinumab 150 mg. We also identified 31 cases of POPP (27 males; mean age 44.9 years) in the literature review. There was great toe involvement in 24 cases, and distal interphalangeal (DIP) involvement in 14 cases, with frequent radiographically evident damage. Seventeen of 31 patients received systematic treatment other than biologics, mostly MTX, with no satisfactory results. Anti-TNF agents were used successfully in 5 cases, mostly after disease modifying...
Source: Clinical Rheumatology - April 8, 2021 Category: Rheumatology Source Type: research

Are antiphospholipid antibodies just a common epiphenomenon or are they causative of immune-mediated coagulopathy in COVID-19?
AbstractThe coronavirus disease 2019 (COVID-19) is the largest public health emergency in recent times. A significant number of patients develop a severe form of COVID-19 characterized by coagulopathy, organ failure, and elevated mortality. In addition, an unusually high frequency of antiphospholipid antibodies (aPLs) has been found in patients with COVID-19. These clinical and serological manifestations closely resemble those seen in the antiphospholipid syndrome (APS), especially in its catastrophic form, suggesting a role of aPLs in immune-associated coagulopathy. However, government bodies such as the American Society ...
Source: Clinical Rheumatology - April 7, 2021 Category: Rheumatology Source Type: research

North American musculoskeletal ultrasound scanning protocol of the hip, knee, ankle, and foot: update of a Delphi consensus study
ConclusionUpdated scanning protocols support modifications reflecting current scanning methods delivered by North American rheumatologists performing point of care ultrasound that may inform educators involved in rheumatology ultrasound.Key Points• The anterior transverse suprapatellar, medial, and lateral longitudinal knee views; the anterior and posterior transverse ankle views; and the lateral longitudinal view hip view were perceived as important to master and perform routinely.• The transverse sacroiliac joint view was suggested to be performed based on practice focus. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 5, 2021 Category: Rheumatology Source Type: research

An elusive mimic of sacroiliitis: diagnostic dilemma for the rheumatologist
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 5, 2021 Category: Rheumatology Source Type: research

Challenging issues in rheumatology: thoughts and perspectives
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 4, 2021 Category: Rheumatology Source Type: research

Does Familial Mediterranean Fever Provoke Atherosclerosis in Children? Evaluation of Arterial Stiffness and Serum Endocan Levels
ConclusionGood disease control could be preventive for atherosclerosis in children with FMF. On the other hand, screening for cardiovascular diseases is essential, particularly for uncontrolled cases.Graphical abstractDistribution of MEFV gene mutationsKey points• Exaggerated inflammation is the prominent feature of FMF attacks; moreover, it is shown that subclinical inflammation might also continue in attack-free periods.• Chronic inflammation contributes to atherosclerotic process in almost all stages by activating endothelial cells, producing reactive oxygen species, and accelerating foam cell and atherosclero...
Source: Clinical Rheumatology - April 4, 2021 Category: Rheumatology Source Type: research

Evaluation of cardiac function and systolic dyssynchrony of fetuses exposed to maternal autoimmune diseases using speckle tracking echocardiography
ConclusionsLV systolic mechanical dyssynchrony in fetuses of mothers with autoimmune antibodies suggests in-utero subclinical damage of the cardiac conduction system.Key points• The left ventricular systolic dyssynchrony was significantly more prolonged in the maternal autoimmune disease (AD) fetuses.• Subclinical damage to the left ventricular conduction system of the fetal heart in maternal AD was observed.• Systolic and diastolic functional of the left and right ventricle were preserved in fetuses exposed to maternal autoimmune disease. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 4, 2021 Category: Rheumatology Source Type: research

Heel fat pad involvement in rheumatoid arthritis: a review and case series
AbstractRheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting not only the synovial joints but also multiple extra-articular sites, including ankle and foot soft tissue. Hindfoot abnormalities usually follow those in the forefoot, with up to 4 out of 10 patients experiencing talalgia during their disease course. Enthesophytosis, retrocalcaneal bursitis, and plantar fasciitis are among the most common etiologies, while heel fat pad abnormalities like subcalcaneal bursitis are rare. Here, we report two cases of subcalcaneal bursitis, and the first case of heel fat pad and subcalcaneal bursa herniat...
Source: Clinical Rheumatology - April 4, 2021 Category: Rheumatology Source Type: research

Evaluation of rheumatoid arthritis and connective tissue disease-related interstitial lung disease with pulmonary physiologic test, HRCT, and patient-based measures of dyspnea and functional disability
AbstractObjectivesWe aim to investigate the relationship between pulmonary function and imaging parameters with symptom-related patient-reported outcome measures (PROs).MethodWe included 65 patients of rheumatoid arthritis (RA) and connective tissue disease (CTD) with and without interstitial lung disease (ILD) into this cross-sectional study. We evaluated the relationship between FVC, DLco, and PROs and compared to HRCT findings. PROs included visual analogue scale for breathing, modified Borg scale, medical research council dyspnea scale, St. George ’s respiratory questionnaire (SGRQ), Leicester cough questionnaire...
Source: Clinical Rheumatology - April 3, 2021 Category: Rheumatology Source Type: research

Efficacy and safety of rituximab therapy in patients with systemic sclerosis disease (SSc): systematic review and meta-analysis
AbstractThe clinical benefits of rituximab in systemic sclerosis (SSc) are still contentious. The present meta-analysis aimed to systematically assess rituximab ’s safety and efficacy profile in SSc patients. A systematic online query was performed in PubMed, Scopus, Web of Science, and Embase. The studies on the application of rituximab for patients with SSc were reviewed comprehensively for over two years. In terms of efficacy profile, mRSS, MS, LVEF, s PAP, FVC, DLCO, TLC, FEV, DAS, severity activity, HAQ-DI and SF36 were assessed for organ involvement and quality of life. The level of biological and immunological...
Source: Clinical Rheumatology - April 2, 2021 Category: Rheumatology Source Type: research

Enthesitis may be one of the signs of severe disease in familial Mediterranean fever
In this study, we have evaluated the association between the enthesitis, enthesitis score and disease severity in FMF patients.MethodsWe enrolled 238 FMF patients that fulfilled the modified Tel-Hashomer criteria. We assessed the presence of enthesitis at the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) defined sites with standard palpation method. Then, FMF patients dichotomised two groups as enthesitis group and controls. Herein, we evaluated the enthesis extensity with MASES. FMF disease severity was determined via the international severity scoring system for FMF (ISSF). Firstly, we have compared demograp...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Clinical and imaging findings suggestive of histopathological immunoglobulin G4-related disease: a single-center retrospective study
AbstractObjectiveTo investigate the clinical and imaging features predicting the histopathological diagnosis of immunoglobulin G4 (IgG4)-related disease (IgG4RD) in patients with suspected IgG4RD on computed tomography (CT).MethodsWe retrospectively reviewed the medical records of 178 patients with CT findings suspicious of IgG4RD from January 2015 to December 2017. Patients who underwent tissue biopsy were included to evaluate the association between patient characteristics and histopathological diagnosis of IgG4RD. The histopathological diagnosis was classified into IgG4RD and non-IgG4RD. Clinical, laboratory, and imagin...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Echocardiographic study of juvenile dermatomyositis patients: new insights from speckle-tracking-derived strain
ConclusionsLV 2DST detected early systolic myocardial compromise in asymptomatic pediatric JDM patients, with preserved EF. Longitudinal strain impairment was associated with disease activity and cumulative damage, whereas circumferential strain impairment was associated exclusively with cumulative damage.Key Points:• Serious cardiac involvement is rare but has been associated with death in juvenile dermatomyositis.• Two-dimensional speckle tracking stands out for the identification of subclinical myocardial compromise in juvenile dermatomyositis.• Longitudinal strain impairment is associated with disease ac...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Fibromyalgia in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: prevalence and screening
AbstractObjectiveTo explore the prevalence, clinical characteristics, and screening strategy for fibromyalgia (FM) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.MethodsA total of 313 patients from a cohort of 354 SAPHO patients volunteered to participate in this study. Demographic, clinical and laboratory data were collected at baseline. Acute-phase reactants during the last 3  months were obtained. Patient-reported outcomes (PROs) and FM evaluation were recorded by questionnaires.ResultsA total of 57 (18.2%) patients met the 2016 research criteria for FM. Compared to those ...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Characteristics and trends in diagnosis of Kawasaki disease outside the usual age range
ConclusionsThe proportion of KD outside the usual age range did not increase over time. Older and younger children have different clinical and laboratory characteristics.Key Points•The number of patients outside the usual age increased over time, but the proportion of these patients did not increase.• Patients aged 0 to 2 months and ≥ 10 years had more delayed diagnoses in their respective age groups.• Younger children had more cases of incomplete KD and abnormal laboratory parameters, while older children had longer duration of fever and were more difficult to diagnose promptly. (Source:...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

The effect of intravenous golimumab on health-related quality of life and work productivity in adult patients with active ankylosing spondylitis: results of the phase 3 GO-ALIVE trial
ConclusionsIn patients with AS, IV golimumab produced sustained improvements in HRQoL and productivity through 1  year, which correlated with improvements in disease activity and functioning.ClinicalTrials.gov registry number is NCT02186873.Key Points•Intravenous (IV) golimumab resulted in clinically important improvement in general and ankylosing spondylitis-specific health-related quality of life (HRQoL) and productivity outcomes in patients with ankylosing spondylitis (AS) as early as week 8 and maintained improvement through 1  year•Improvements in HRQoL and productivity outcomes in these patients w...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Cultural adaptation and validation of the Systemic Sclerosis Quality of Life questionnaire into Arabic language
AbstractBackground and objectivesSystemic sclerosis (SSc) is a chronic connective tissue disease affecting all quality of life (QoL) parameters. In addition to clinical assessment, QoL measures should be included in patient assessment. There is no Arabic tool specific for assessing QoL in Arabic SSc patients; therefore, this work was designed to translate the SScQoL questionnaire, culturally adapt and check its reliability and validity.MethodBased on the principle of translation and cross-cultural adaptation in other language, the SScQoL questionnaire was translated into Arabic. Correlation of SScQoL scores for 50 patients...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Characteristics and outcome of a first acute myocardial infarction in patients with ankylosing spondylitis
ConclusionsPatients with AS tend to have a higher comorbidity burden at admission for first AMI. The mortality after a first AMI due to cardiovascular-related causes does not seem to be elevated, despite an increased overall mortality during days 31 –365 among patients with AS compared with the general population.Key Points• The all-cause mortality after a first AMI was higher in patients with AS.• Mortality after a first AMI due to CVD-related causes does not seem to be elevated for patients with AS.• In patients with AS suffering a first AMI, more attention should be given to other comorbidities caus...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Non-radiographic axial spondyloarthritis in Tunisia: main characteristics and detailed comparison with ankylosing spondylitis
ConclusionThe non-radiographic axial spondyloarthritis is characterized mainly by a marked female prevalence, a higher enthesitis prevalence, and a better physical function.Key points:• Patients with nr-axSpA in Tunisia are more frequently female and have shorter disease duration compared with those with AS.• Peripheral manifestations were similar between nr-axSpA and AS patients except for enthesitis which were more frequent within nr-axSpA patients.• The disease activity is similar between the 2 groups of axSpA but the physical function is better within nr-axSpA patients. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Rheumatoid lung nodules with “feeding-vessel” sign
We describe a woman with long-standing rheumatoid arthritis with subcutaneous and pulmonary nodules. Computed tomography of the chest show ed “feeding-vessel” sign. There was no evidence of infection, malignancy, or vasculitis. She was treated for rheumatoid lung nodulosis with rituximab with which she improved remarkably. To the best of our knowledge, “feeding-vessel” sign in rheumatoid lung nodules has never been reported bef ore. This case highlights the fact that “feeding-vessel” sign is not specific for pulmonary infections. It can rarely be seen in rheumatoid lung nodulosis. (Sourc...
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Pseudotumour cerebri in lupus
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 9, 2021 Category: Rheumatology Source Type: research

Prevalence of liver fibrosis by Fibroscan in patients on long-term methotrexate therapy for rheumatoid arthritis
ConclusionsLong-term MTX therapy in RA was associated with increased liver stiffness on Fibroscan.Key Points•Fibroscan is a useful tool for monitoring MTX-induced liver fibrosis.•Liver fibrosis as evidenced by increased liver stiffness on Fibroscan is prevalent among patients on long-term MTX therapy for RA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 8, 2021 Category: Rheumatology Source Type: research

Identification of differentially expressed genes in synovial tissue of osteoarthritis based on a more robust integrative analysis method
ConclusionsSeventy DEGs were finally identified with a more robust integrative analysis method.JUN,IL6,VEGFA,MYC, andEGR1 were identified as hub genes in the development of OA.Key Points• 76 overlapping DEGs were detected from the intersection of DEGs in GSE55457, GSE12021, and GSE55235.• 242 DEGs were identified by integrating four series using Sva package.• 72 common DEGs were finally identified based on the overlapping DEGs and the integrated DEGs.• JUN, IL6, VEGFA, MYC, and EGR1 were identified as hub genes in the development of OA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 6, 2021 Category: Rheumatology Source Type: research

Patient-controlled outpatient follow-up on demand for patients with rheumatoid arthritis: a 2-year randomized controlled trial
This study aims to compare a patient-controlled outpatient follow-up system, Open Outpatient Clinic Programme (OOCP), with traditional scheduled routine follow-up (TSRF) regarding patient satisfaction and disease activity markers in RA patients.MethodIn a 2-year randomized controlled trial, RA patients were allocated to OOCP or TSRF. OOCP patients had no scheduled appointments but were allowed acute appointments with their rheumatologist and had access to nurse-led consultations and a telephone helpline. Appointments for the TSRF group were scheduled according to routine procedures (clinical parameters: DAS-28, C-reactive ...
Source: Clinical Rheumatology - March 6, 2021 Category: Rheumatology Source Type: research

The impact of SARS-CoV-2 coronavirus infection in patients with systemic lupus erythematosus from a single center in Catalonia
AbstractObjectiveTo evaluate the incidence and characteristics of SARS-CoV-2 infection among patients with systemic lupus erythematosus (SLE) and to compare it to that described in the general population.MethodsFor 5 weeks, we carried out a cross-sectional study consisting of telephone interviews of SLE patients. We collected epidemiological data, symptoms suggesting COVID-19, results of nasopharyngeal swabs, and ongoing treatments. In those patients who required hospital admission, clinical, radiological, and laboratory features, and outcome were investigated.ResultsFour hundred patients with SLE completed the survey. Ove...
Source: Clinical Rheumatology - March 6, 2021 Category: Rheumatology Source Type: research

Systemic sclerosis is associated with lower limb vascular stiffness and microvascular impairment: results from a prospective study
AbstractObjectiveSystemic sclerosis (SSc) is a connective tissue disease characterized by microangiopathy. Peripheral arterial disease, increasingly studied during SSc, is responsible for digital ulcers, associated with a high risk of amputation. The aim of our study was to assess the frequency of lower limb arterial impairment in SSc patients by measuring ankle-brachial index (ABI), toe pressure (TP), and toe-brachial index (TBI).MethodsSystemic sclerosis patients were included prospectively during 1 year in Tenon and Saint-Antoine Hospitals, Paris. Clinical and biological data were recorded. For each patient, ABI, TP, an...
Source: Clinical Rheumatology - March 6, 2021 Category: Rheumatology Source Type: research

Prevalence of pediatric Kashin-Beck disease in Tibet
We examined association between site involvement and severity of KBD using chi-square test.ResultsWe recruited 13,573 children (mean age = 9.3 years, 48.40% girls) with a response rate of 95.81%. The overall prevalence of radiographic KBD was 0.26%. Luolong County had the highest prevalence (0.69%), followed by Bianba (0.26%), Basu (0.24%), Mangkang (0.14%), Zuogong (0.14%), Dingqing (0.07%), and Chaya (0.00%). A higher risk of radiographic KBD was associated with older age (P for trend
Source: Clinical Rheumatology - March 5, 2021 Category: Rheumatology Source Type: research

Effects of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in patients with rheumatoid arthritis: a randomized double-blind placebo-controlled trial
AbstractObjectiveConsidering the pathologic significance of inflammation and oxidative stress in rheumatoid arthritis (RA) as well as the antioxidant, anti-inflammatory and hypolipidemic effects of melatonin, the current research is designed to investigate the effect of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in RA patients.MethodsIn this randomized double-blind, placebo-controlled trial, 64 RA cases were selected and randomly assigned into 2 groups to take 6 mg/day melatonin or placebo for 12 weeks. Before and after trial, serum malondialdehyde (MDA), total a...
Source: Clinical Rheumatology - March 5, 2021 Category: Rheumatology Source Type: research

Evaluation of a lateral flow assay –based IFN-γ release assay as a point-of-care test for the diagnosis of latent tuberculosis infection
ConclusionsThe ichroma ™ IGRA-TB could be used as a point-of-care test for LTBI screening in IMID patients before starting biologics, especially in resource-limited settings.Key Points• The ichroma™ IGRA-TB is an automated fluorescence lateral flow assay–based IGRA.• The test has advantages like short turn-around time, low-cost, and ease of use.• The ichroma™ IGRA-TB showed high agreement with the QuantiFERON-TB Gold In-Tube in patients with chronic immune-mediated inflammatory diseases before starting biologics. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 5, 2021 Category: Rheumatology Source Type: research

Juvenile dermatomyositis with gingival vasculopathy
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 4, 2021 Category: Rheumatology Source Type: research

Transbronchial lung cryobiopsy for connective tissue disease –related interstitial lung disease and interstitial pneumonia with autoimmune features: a single center retrospective case series
ConclusionTBLC can add extra diagnostic value by effectively identifying specific types of histology for patients with suspected CTD-ILD or IPAF, with a procedure that is safe from adverse events.Key Points•Transbronchial lung cryobiopsy has been introduced recently for diagnosing interstitial lung disease.•Transbronchial lung cryobiopsy was found to be effective and safe in the diagnosis for patients with suspected interstitial lung disease. It can be used as a preferred method for biopsy when the clinical-radiological diagnosis is uncertain. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 3, 2021 Category: Rheumatology Source Type: research

The effect of intravenous golimumab on health-related quality of life and work productivity in patients with active psoriatic arthritis: results of the Phase 3 GO-VIBRANT trial
ConclusionIV golimumab resulted in early and sustained improvements in HRQoL and productivity from Week 8 through 1 year in patients with PsA. HRQoL and productivity improvements were associated with improvements in disease activity and patient functional capability.Key Points•In patients with active psoriatic arthritis (PsA), intravenous (IV) golimumab improved health-related quality of life (HRQoL) and productivity as early as 8 weeks and maintained improvement through 1 year•Improvements in HRQoL and productivity outcomes in patients with PsA treated with IV golimumab were associated with improvements in disea...
Source: Clinical Rheumatology - March 2, 2021 Category: Rheumatology Source Type: research

Cutaneous manifestations are frequent and diverse among patients with rheumatoid arthritis and impact their quality of life: a cross-sectional study in a cohort of patients with recent-onset disease
ConclusionsCutaneous manifestations are frequent in RA patients and have the potential to impact the emotional component of health-related quality of life.Key Points• Up to 77% of the RA patients with substantial follow-up, from a recent-onset disease cohort, had cutaneous manifestations; these were primarily RA-nonspecific findings, whereas 13.1% had RA-specific findings.• Skin-health concerns and age were associated with cutaneous involvement; meanwhile, increased age and Dermatology Life Quality Index (DLQI) score were associated with a higher number of cutaneous findings/patient.• Reduced dermatological ...
Source: Clinical Rheumatology - March 2, 2021 Category: Rheumatology Source Type: research

Utilization of acute gout prophylaxis in the real world: a retrospective database cohort analysis
AbstractObjectiveDetermine the real-world incidence of acute gout prophylaxis (AGP) prescribing when a xanthine oxidase inhibitor (XOI) is initiated and describe characteristics of AGP prescribing.MethodsRetrospective cohort analysis from 2007 to 2017 using medical and prescription claims from an administrative database (IQVIA ™ Health Plan Claims Database) among adult patients with a diagnosis of gout. Primary endpoint was the proportion of patients receiving AGP among all patients newly initiated on XOI therapy. Secondary endpoints included incidence proportions of acute flare and of XOI discontinuation among patie...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Interleukin 6, interleukin 17, disease-related and contextual factor association with depression, and its severity in patients with rheumatoid arthritis
ConclusionDepression is frequent in RA and is strongly associated to elevated serum IL-6, IL-17, CRP levels, and disease activity-related factors.Key Points• RA patients are at increased risk of developing depression, particularly if their level of disease activity scores, serum IL-6, and IL-17 levels increases.• Patient characteristics associated with depression in RA include living without family, without employments, and with co-morbid hypertension, while RA disease factors are pain, functional disability, and high disease activity.• A multidisciplinary cooperative approach to RA patient care with regular...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

The relationship between JAK2 (V617F) mutation and dermatomyositis —a case report and literature review
AbstractThe JAK family (JAK1, JAK2, JAK3, and TYK2) have recently emerged as a potential therapeutic management in controlling severe and refractory dermatomyositis. Meanwhile, the progress in the discovery of JAK blockers is significant, with an increasing number of selective JAK inhibitors reported and some are in or prepare for clinical trials. However, the importance of each JAK in dermatomyositis is unclear, which is critical for a comprehensive understanding of dermatomyositis and significant for forming mechanism-based strategy. Here, we presented a case with clinically amyopathic dermatomyositis and essential throm...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

The influence of prior opioid use on healthcare utilization and recurrence rates for non-surgical patients seeking initial care for patellofemoral pain
ConclusionsPrior opioid utilization was associated with a greater number of recurrent episodes of knee pain and higher downstream medical costs compared with individuals without prior opioid use. For individuals with prior opioid utilization, opioids with higher risk of misuse or dependency (Schedule II or III) resulted in greater medical costs (for any reason) and recurrent episodes compared to the use of lower-risk opioids (Schedule IV).Key Points•Patients with prior opioid use had much greater knee-related medical costs compared to patients without prior opioid use.•Patients with prior opioid use were more lik...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Does hand involvement in systemic sclerosis limit completion of patient-reported outcome measures?
The objective of this analysis is to examine whether the severity of systemic sclerosis (SSc)-hand involvement influences patient-reported outcome measure (PROM) completion rate in a US cohort of early disease. Participants included SSc patients with less than 5 years disease duration consented and enrolled in the Collaborative, National, Quality, and Efficacy Registry (CONQUER) between June 2018 and December 2019. Participants ’ socio-demographics, hand clinical features (severe modified Rodnan skin score, presence of small joint contractures, acro-osteolysis, calcinosis, and digital ulcers), and completion rates of...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Dose tapering of biologic agents in patients with rheumatoid arthritis —results from a cohort study in Germany
AbstractObjectiveTo assess the association of demographic and clinical factors with the clinical decision of tapering biologic disease modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) in daily practice.MethodsAll RA patients receiving bDMARDs were documented by 14 rheumatologists when presenting in 9 specialized private practices. Statistical analyses employed multivariable logistic models for dose reduction with the covariates age, gender, disease duration until bDMARD start, smoking status, disease activity, comorbidity, functional capacity, radiographic damage, concomitant methotrexate ...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Vasculitis beyond aortitis in IgG4-related disease (IgG4-RD): case report and review of the literature
AbstractIgG4-related disease (IgG4-RD) can affect almost every tissue/organ. Vascular involvement in the setting of IgG4-RD is increasingly being recognized with most of the cases pertaining patients with aortitis and/or periaortitis with or without aneurysm formation. However, it is now evident that other vessels like iliac arteries, coronary arteries, carotids, and others can also be affected being often underdiagnosed. Vascular involvement is expressed as vessel wall thickening, while aneurysm formation is also occasionally seen. Although histopathological findings are the cornerstone in the diagnosis of IgG4-RD, imagin...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Acknowledgement to Referees 2020
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Does healthcare regime affiliation influence the clinical outcomes of patients with rheumatoid arthritis?
This study aimed to compare the disease outcomes of patients with RA, based on their healthcare regime affiliation.MethodsA retrospective observational study of Colombian patients with RA in three outpatient services of different regimes: Contributory (CR, workers and their families with a monthly income above a yearly defined threshold, approximately US$ 220, who allocate a percentage of their income to financing the national health fund and to get access to healthcare services), subsidized (SR, a vulnerable population with a monthly income below the threshold, who have access to healthcare through the national health fun...
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Cutaneous features of anti-TIF1- γ-associated dermatomyositis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Characteristics and evolution of 38 patients with rheumatic diseases and COVID-19 under DMARD therapy
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Sonozaki syndrome in the spotlight of imaging
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research

Localized conjunctival amyloidosis due to familial Mediterranean fever
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2021 Category: Rheumatology Source Type: research