Evaluation of the international severity score for FMF (ISSF) scores in Turkish children diagnosed with FMF: a single-center experience
ConclusionsISSF appears as a suitable and effective tool for the physicians in the follow-up of the disease severity in pediatric FMF patients.Key Points•Our article is the first study to evaluate ISSF performance in the pediatric population.•International severity score for FMF (ISSF) appears as a suitable and effective tool for the physicians in the follow-up of the disease severity in pediatric FMF patients.•We think that the addition of pathogenic mutations and inheritance model to the ISSF scoring system as important determinants of disease severity, especially when comparing different patients, can be ...
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Investigating the relationship between the severity of periodontitis and rheumatoid arthritis: a cross-sectional study
AbstractObjectivesThis paper evaluates the prevalence and severity of periodontitis (PD) in patients with rheumatoid arthritis (RA), focusing on the link between the severity of PD with RA disease activity/disability scores, the influence of RA treatment on PD, and levels of vitamin D.MethodsA total of 93 RA patients were enrolled in the cross-sectional study and analyzed accordingly as RA-PD (N = 63, 67.8%) and RA-only (N = 30, 32.2%) groups. A number of associations between rheumatological clinical data, i.e., Disease Activity Score (DAS28 CRP), health assessment questionnaires, and PD severity (measured by periodontal o...
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Comparing symptoms, treatment patterns, and quality of life of ankylosing spondylitis and non-radiographic axial spondyloarthritis patients in the USA: findings from a patient and rheumatologist Survey
AbstractObjectivesThe aim of this study was to compare the symptoms, treatment patterns, and quality of life (QoL) of ankylosing spondylitis (AS) patients to non-radiographic axial spondyloarthritis (nr-axSpA) patients in the USA.MethodA cross-sectional survey was conducted with rheumatologists and their consulting patients in the USA from June through August 2018. Patients who had a rheumatologist confirmed diagnosis of AS and nr-axSpA were eligible to participate. Patient demographics, symptoms, and medication use were reported by the rheumatologist, while work disability and QoL measures were reported by the patient. Pa...
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Sexual and mental health of woman suffering from selected connective tissue diseases: an original paper
ConclusionThe study confirms the existence of difficulties in the sexual functioning of women suffering from connective tissue diseases and shows the relationship between sexual and mental health and basic disease. The observed relationships are important information in the treatment and medical care of people with this group of rheumatic diseases.Key Points• The article presents one of the few studies about sexual functioning of Polish population women with connective tissue diseases.• The aim was to assess the sexual and mental health of women with various connective tissue diseases and determine the potential ...
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Synchronous skin lesions in mother and baby with neonatal lupus erythematosus
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

HLA-subtypes B*27 and ankylosing spondylitis features comments on Fellahi ’s article “Are early onset of disease and uveitis affected by HLA- subtypes B*27 in ankylosing spondylitis?”
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Retraction Note: Comparison of the effect of alendronate on lumbar bone mineral density and bone turnover in men and postmenopausal women with osteoporosis
A correction to this paper has been published:https://doi.org/10.1007/s10067-021-05788-3 (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Retraction Note: Effects of alendronate on metacarpal and lumbar bone mineral density, bone resorption, and chronic back pain in postmenopausal women with osteoporosis
This article has been retracted. Please see the Retraction Notice for more detail:https://doi.org/10.1007/s10067-021-05787-4 (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Editorial Expression of Concern: Experience with alendronate treatment for 7  years among Japanese men with osteoporosis or osteopenia and clinical risk factors for fractures
An Editorial Expression of Concern to this paper has been published:https://doi.org/10.1007/s10067-021-05796-3 (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Correction to: Challenging issues in rheumatology: thoughts and perspectives
A Correction to this paper has been published:https://doi.org/10.1007/s10067-021-05798-1 (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 19, 2021 Category: Rheumatology Source Type: research

Natural developing process of immunoglobulin G4-related sialadenitis after submandibular gland excision: a retrospective cohort study
ConclusionsSurgical excision of involved SMG cannot control the disease progression, which is not recommended for treatment of IgG4-RS. Differential diagnosis is crucial in order to prevent irreversible organ loss and relevant salivary gland dysfunction.Key Points•Surgical excision of involved SMG cannot control progression of IgG4-RS. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 18, 2021 Category: Rheumatology Source Type: research

Engagement process for patients with spondyloarthritis: PANLAR early SpA clinics project — centers of excellence
The objective of this work is to propose a care model that is adaptable to the factual realities of Latin America. A systematic search of the literature terms (MeSH) was performed to search associated terms. Taking the model of the REAL-PANLAR project as an example and incorporating some related literature, a model of centers of excellence for SpA in Latin America is proposed that can be reasonably established and implemented. This model proposes 3 types of centers of excellence for SpA according to the level of complexity of each institution, and its criteria are defined based on indicators of structure, processes, and re...
Source: Clinical Rheumatology - July 17, 2021 Category: Rheumatology Source Type: research

Gastrointestinal involvement in IgA vasculitis: a single-center 11-year study on a cohort of 118 children
ConclusionsThe present study describes a large pediatric cohort of GI involvement in IgAV. Steroid treatment should be used when GI manifestations are severe. The association of steroid use with relapse risk is not currently established. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 17, 2021 Category: Rheumatology Source Type: research

Doppler ultrasound impacts response to intravenous tocilizumab in rheumatoid arthritis patients
This study sought to determine if baseline PDUS or its early changes can predict 12-week and 24-week disease activity outcomes, and quantify the need for dose escalation (4 to 8  mg/kg).MethodsFifty-four RA patients starting IV-TCZ were evaluated at baseline, 4, 6, 12, 16, and 24  weeks using 34-joint PDUS (US34-PDUS), clinical disease activity index (CDAI), 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR), ACR 20/50/70, health assessment questionnaire-disability index (HAQ-DI), and PDUS 20/50/70, a novel measure. Logistic regression models e valuated the predictive utility of US34...
Source: Clinical Rheumatology - July 16, 2021 Category: Rheumatology Source Type: research

On the efficacy and safety of rituximab therapy in patients with systemic sclerosis disease: missing points, bottlenecks, over-exaggeration, and discrepancies —comments on the article by Moradzadeh et al.
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 16, 2021 Category: Rheumatology Source Type: research

Simple metabolic markers associated with tophaceous gout
AbstractIntroductionThe relationship between tophaceous gout and metabolic markers is not well understood. The aim of this study was to compare the correlations between different metabolic markers and tophi and evaluate their potential predictive values for tophus.MethodWe analysed the data of gout patients in Beijing Jishuitan Hospital from 2013 to 2020. Ten laboratory indicators (UA, eGFR, underexcretion, GLU, TRIG, HDL-C, ALT, TBIL, γ-GT and UPH) were included to evaluate the relationship between tophaceous gout and metabolic markers.ResultsTophi was present in 14.7% (119/808) of gout patients. UA, eGFR, ALT and &...
Source: Clinical Rheumatology - July 15, 2021 Category: Rheumatology Source Type: research

Incidence, mortality, and national costs of hospital admissions for potentially preventable infections in patients with rheumatoid arthritis
ConclusionInfections, such as influenza, HZV, andS. pneumoniae, remain a common cause of inpatient morbidity and mortality among RA patients. Additionally, the economic burden of these infections is significant. Universal vaccination programs in RA patients, as well as other interventions aiming to improve quality of care of this susceptible population, should be further studied to reduce hospitalizations, cost, morbidity, and mortality.Key Points•Streptococcus pneumoniae, herpes zoster, and influenza infections remain an important preventable cause of hospitalizations among RA patients and carry significant economic ...
Source: Clinical Rheumatology - July 12, 2021 Category: Rheumatology Source Type: research

Carpal tunnel syndrome revealing a fibrolipoma of the median nerve
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 11, 2021 Category: Rheumatology Source Type: research

Characterisation of first metatarsophalangeal joint osteoarthritis using magnetic resonance imaging
ConclusionsOsteophytes, bone marrow lesions, subchondral cysts, effusion-synovitis, joint space narrowing, and cartilage loss are characteristic MRI features of first MTP joint OA. First MTP joint OA is a disease of multiple joint tissues and this has implications for the assessment and management of this condition.Key Points•First metatarsophalangeal joint osteoarthritis is a disease of multiple joint tissues.•Osteophytes, bone marrow lesions, subchondral cysts, effusion-synovitis, joint space narrowing, and cartilage loss are characteristic MRI features of first metatarsophalangeal joint osteoarthritis.•Th...
Source: Clinical Rheumatology - July 9, 2021 Category: Rheumatology Source Type: research

Multidisciplinary approach in the treatment of tendinous foot involvement in rheumatoid arthritis
ConclusionsOur multidisciplinary therapeutic protocol enabled a very significant improvement in tendon involvement. It was well-tolerated, with a high degree of satisfaction, and was easily evaluated using ultrasound. No changes in background medication were necessary.Key Points•Multidisciplinary evaluation of patients with RA is advisable because it improves the treatment management in cases of inflammatory activity and structural abnormalities of the foot.•Comprising orthopedic-podiatric treatment (heel, splints, and suitable footwear) and infiltrations, in terms of clinical, ultrasound, and functional recovery...
Source: Clinical Rheumatology - July 6, 2021 Category: Rheumatology Source Type: research

Thyroid disorders in familial Mediterranean fever: think about AA amyloidosis!
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 6, 2021 Category: Rheumatology Source Type: research

Trends in hospitalizations for vertebral compression fracture in ankylosing spondylitis: data from the National Inpatient Sample 2000 –2014
AbstractAnkylosing spondylitis (AS) patients are at increased risk of vertebral compression fractures (VCF). Our objective was to examine the yearly trend of VCF hospitalizations in AS patients as compared to rheumatoid arthritis (RA) and the general population. National Inpatient Sample (NIS) database (2000 –2014) was used to identify adult (≥ 18 years) hospitalizations, based on validated ICD-9 diagnosis codes. The rate of VCF hospitalizations, as a primary diagnosis, was assessed in three mutually exclusive groups: AS, RA, and the general population. The prevalence of VCF hospitalization was h ighes...
Source: Clinical Rheumatology - July 5, 2021 Category: Rheumatology Source Type: research

Identification of differential key biomarkers in the synovial tissue between rheumatoid arthritis and osteoarthritis using bioinformatics analysis
ConclusionDifferential expression ofCXCL13,CXCL10, andADIPOQ between RA and OA synovial tissue may provide new insights for understanding the RA development and difference between RA and OA.Key Points•Bioinformatics analysis was used to identify the differentially expressed genes in the synovial tissue between rheumatoid arthritis and osteoarthritis.•CXCL13, CXCL10, and ADIPOQ might provide new insight for understanding the differences between RA and OA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 5, 2021 Category: Rheumatology Source Type: research

Ability and willingness to utilize telemedicine among rheumatology patients —a cross-sectional survey
This study aims to assess the patients ’ ability and willingness to utilize telemedicine (TM) along with identifying some of the barriers to a more widespread adoption of TM in rheumatology.Methods An observational, cross-sectional study of patients visiting a rheumatology clinic was conducted in 2018. We used a survey to assess patients ’ attitude on the perceived effectiveness when comparing TM versus in-person visits, as well as patients’ access to technology, distance traveled by the patient to attend the clinic visit, and demographic parameters.ResultsA total of 214 patients were included. Negative...
Source: Clinical Rheumatology - July 4, 2021 Category: Rheumatology Source Type: research

Real-world data on MTX tolerance with regimens used in children versus adults
This study aims to evaluate and compare the frequency of methotrexate intolerance in adult and pediatric patients.MethodsPatients with a rheumatic disease who used oral or parenteral methotrexate for at least 3  months were included in the study. Methotrexate intolerance was assessed using the Methotrexate Intolerance Severity Score (MISS) questionnaire and visual analog scale (VAS). In the pediatric patient group, the MISS questionnaire and VAS assessment were applied to both patients and families.ResultsA total of 200 patients, 100 of whom were children, were enrolled in the study. The mean age for children and adul...
Source: Clinical Rheumatology - July 4, 2021 Category: Rheumatology Source Type: research

Antimalarial drugs —are they beneficial in rheumatic and viral diseases?—considerations in COVID-19 pandemic
AbstractThe majority of the medical fraternity is continuously involved in finding new therapeutic schemes, including antimalarial medications (AMDs), which can be useful in combating the 2019-nCoV: coronavirus disease (COVID-19). For many decades, AMDs have been widely used in the treatment of malaria and various other anti-inflammatory diseases, particularly to treat autoimmune disorders of the connective tissue. The review comprises in vitro and in vivo studies, original studies, clinical trials, and consensus reports for the analysis, which were available in medical databases (e.g., PubMed). This manuscript summarizes ...
Source: Clinical Rheumatology - July 3, 2021 Category: Rheumatology Source Type: research

Polycystic ovary syndrome: epidemiologic assessment of prevalence of systemic rheumatic and autoimmune diseases
AbstractBackgroundPolycystic ovary syndrome (PCOS) causes anovulation and hyperandrogenism. Hormonal imbalance is known to contribute to systemic autoimmune diseases.ObjectiveTo examine the frequency of certain rheumatic diseases in PCOS.MethodsThis retrospective study utilized and analyzed electronic medical records from January 2004 through February 2020. A diagnosis of PCOS and specified rheumatic diseases was searched using ICD-9 and ICD-10 codes. A total of 754 adult patients with PCOS and 1,508 age- and body mass index –matched patients without PCOS were included. Frequencies of the rheumatic diseases were comp...
Source: Clinical Rheumatology - July 3, 2021 Category: Rheumatology Source Type: research

Depression and anxiety might not be increased during COVID-19 pandemic in patient with axial spondyloarthritis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 3, 2021 Category: Rheumatology Source Type: research

A bibliometric analysis of rheumatology and COVID-19 researches
ConclusionsBibliometric analysis of rheumatology and COVID-19 can be useful to future studies because it provides a general perspective on the studies. This study provides an insight into the development of publications on rheumatology during the COVID-19 pandemic.Key Points•Covid-19 has substantial impact on rheumatology.•There many studies about rheumatology and COVID-19. But there is no study about bibliometric analysis of these studies.•This study provides a general perspective of the studies about rheumatology and COVID-19.•This study aims to inform the efforts to improve the studies about rheumato...
Source: Clinical Rheumatology - July 2, 2021 Category: Rheumatology Source Type: research

Platelet distribution width is highly associated with thrombotic events in primary antiphospholipid syndrome
The objective of this study was to evaluate the association between platelet indices and thrombotic events in patients with primary APS.MethodsThis single-center cross-sectional study included 207 consecutive patients with APS treated at our institution between 2010 and 2019. Results of blood tests were recorded retrospectively from medical records.ResultsOf the included patients, 135 (65.2%) were female and 72 (34.8%) were male. They were classified into thrombotic (n = 150) or non-thrombotic (n = 57) groups. PDW, mean platelet volume, and large platelet ratio were significantly higher in the t...
Source: Clinical Rheumatology - July 2, 2021 Category: Rheumatology Source Type: research

Genicular nerve block in rheumatoid arthritis: a randomized clinical trial
ConclusionGNB is a new promising local therapy for RA to control pain, improve function, and alleviate inflammation of the knee joint. Although it has a relatively short-term effect, yet it has outperformed the steroid effect.Key Points•Knee monoarthritis treatment in rheumatoid arthritis is always challenging•GNB has been approved for the treatment of pain in knee osteoarthritis•GNB in this study was able to control active knee arthritis and this effect persisted longer thane intra-articular steroid injection (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 2, 2021 Category: Rheumatology Source Type: research

Comparative effectiveness of mycophenolate mofetil versus cyclophosphamide in systemic sclerosis-related interstitial lung disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 2, 2021 Category: Rheumatology Source Type: research

Correction to: Advanced glycation end products, advanced oxidation protein products, and ferric reducing ability of plasma in patients with rheumatoid arthritis: a focus on activity scores
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - July 1, 2021 Category: Rheumatology Source Type: research

Rheumatology health care providers ’ views and practices on obesity and smoking cessation management in rheumatoid arthritis
ConclusionMost rheumatology HCPs understood the implications of cigarette smoking and obesity in RA and accepted responsibility in addressing these issues. However, they lacked the time, training, confidence, and knowledge of local resources to do so effectively. There is a need to bridge this gap.Key Points•Training through medical and nursing school as well as residency on weight management and smoking cessation counselling was nearly unanimously described as poor or fair.•Most rheumatology health care providers understood the implications of cigarette smoking and obesity in rheumatoid arthritis and accepted re...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Time-trends in cocaine, hallucinogen, amphetamine, and sedative/anxiolytic/hypnotic use disorder hospitalizations in rheumatic diseases: a national time-trends study
This study ’s objective was to examine the frequency and rates of common drug/substance use disorder hospitalizations in five MSDs, namely gout, osteoarthritis, fibromyalgia, rheumatoid arthritis, and low back pain. This was achieved by using the diagnostic codes for cocaine, hallucinogen, amphetamine, or AS H use disorder hospitalization in five MSDs in the US National Inpatient Sample from 1998 to 2014. Cocaine, hallucinogen, amphetamine, or ASH use disorder hospitalizations per 1 million NIS total hospitalizations for five MSDs in 2013–2014 were as follows, respectively: gout, 10.2, 0.1, 2.8, and 1 .5; osteo...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infa...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Mycophenolate in idiopathic inflammatory myositis: outcome data of a large South Asian cohort
ConclusionMycophenolate is an effective treatment  option in IIM patients with and without co-existing ILD. Presence of Gottron’s rash and absence of pericardial effusion were found to be predictors of favourable clinical outcome in this largest single-centre study.Key points•This largest single-centre study of South Asian adult patients with idiopathic inflammatory myositis showed good clinical outcome and survival with combination treatment regimen consisting of upfront immunosuppressant especially mycophenolate mofetil or sodium (MMF/MMS) along with tapering doses of steroids.•Absence of pericardial...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Drug retention of sarilumab, baricitinib, and tofacitinib in patients with rheumatoid arthritis: the ANSWER cohort study
ConclusionsAfter adjustment by potent confounders, SAR, BAR, and TOF showed similar discontinuation rates due to lack of effectiveness and toxic adverse events.Key Points• This is the first retrospective multicenter study that aimed to clarify the retention rates and reasons for discontinuation of SAR, BAR, and TOF in patients with RA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Cutaneous vasculitis in lupus treated with IV immunoglobulin
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients
ConclusionThis study increases the number of known JIA risk loci and provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis. The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that confer susceptibility to JIA in Estonian patients.Key Points•Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease with heterogeneous presentation and genetic predisposition.•Present genome-wide association study for Estonian JIA patients is ...
Source: Clinical Rheumatology - June 8, 2021 Category: Rheumatology Source Type: research

Coincident Kikuchi-Fujimoto ’s disease and adult-onset Still’s disease: report of a patient from an uncommonly affected population and case-directed systematic review
AbstractKikuchi-Fujimoto's disease (KFD) and adult-onset Still ’s disease (AOSD) are rare idiopathic inflammatory conditions of unknown etiology. Ten prior instances of KFD and AOSD occurring together have been reported in the medical literature. These overlaps, together with certain distinguishing clinical and laboratory characteristics in these co-occurrenc es, offer insight into the pathophysiology of both of these rare disorders. Too, examination of these cases may help improve the diagnostic evaluation and care of patients afflicted with these rare diseases. We therefore report an additional patient with KFD and...
Source: Clinical Rheumatology - June 7, 2021 Category: Rheumatology Source Type: research

Performances of single tube nested polymerase chain reaction and GeneXpert ultra on Formalin fixed paraffin embedded tissues in the diagnosis of tuberculous spondylodiscitis
ConclusionNested PCR and GeneXpert ultra on formalin fixed paraffin embedded tissues are useful tools for the diagnosis of tuberculous spondylodiscitis, especially for cases where microbiological investigations were not carried out. Both techniques have excellent specificity but single tube nested PCR is more sensitive.Key Points• Molecular techniques are routinely performed on fresh tissues• GeneXpert and nested PCR on formalin fixed paraffin embedded tissues are reliable for the diagnosis of tuberculous spondylodiscitis• Nested PCR is more sensitive than Genexpert for diagnosing tuberculous spondylodisciti...
Source: Clinical Rheumatology - June 7, 2021 Category: Rheumatology Source Type: research

Clinical features and outcomes of 76 patients with COVID-19-related multi-system inflammatory syndrome in children
ConclusionAlthough there is a wide clinical variability among the patients with MIS-C, we suggest that those with older age and lower initial serum albumin levels merit close monitoring due to their higher risk for PICU admission.Key Points•Although there is a wide variability regarding the management process among clinicians, MIS-C is a rare, severe, less understood complication of COVID-19 that may cause rapid clinical deterioration in the patients.•Clinicians should be aware of this condition in children with persistent fever and a family history of COVID-19.•Older age and low serum albumin levels are the...
Source: Clinical Rheumatology - June 5, 2021 Category: Rheumatology Source Type: research

Efficacy of mycophenolate mofetil versus cyclophosphamide in systemic sclerosis-related interstitial lung disease: a systematic review and meta-analysis
ConclusionsThe efficacy of MMF with respect to FVC and DLco improvement is comparable to that of CYC, and MMF is preferred on the basis of the occurrence of adverse events.Key Points• A systematic review and meta-analysis was conducted to compare the efficacy and adverse events of mycophenolate mofetil and cyclophosphamide in patients with systemic sclerosis-related interstitial lung disease.• The efficacy of MMF with respect to FVC and DLco improvement is comparable to that of CYC, and MMF is preferred on the basis of the occurrence of adverse events. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - June 2, 2021 Category: Rheumatology Source Type: research

Incidence of autoimmune diseases in people living with HIV compared to a matched population: a cohort study
The objective of this paper is to estimate incidence and relative risk of autoimmune conditions in patients living with HIV compared to an HIV-negative matched population. We conducted a retrospective study in the medico-administrative database of the province of Qu ébec, Canada. All HIV-positive patients treated with antiretrovirals were matched to up to 4 HIV-negative controls for age, sex, and period of follow-up. The following autoimmune conditions were identified using medical billing codes: vasculitis, hematological (immune thrombocytopenic purpura and i mmune hemolytic anemia), ankylosing spondylitis, psorias...
Source: Clinical Rheumatology - May 14, 2021 Category: Rheumatology Source Type: research

Risk of progression of idiopathic pulmonary fibrosis to connective tissue disease: a long-term observational study in 527 patients
AbstractObjectiveConnective tissue disease (CTD) might occur during the course of idiopathic pulmonary fibrosis (IPF). Clinical factors associated with CTD development in IPF patients have still not been identified. We investigated which antibodies have a significant association with the development of CTD during the clinical course of IPF.MethodsWe retrospectively reviewed the records of 527 patients with a first diagnosis of IPF between January 2007 and March 2014 and investigated the time to CTD development after IPF diagnosis in these patients.ResultsCTD developed in 15 patients at a median of 2.1 years (range 1.2 &nda...
Source: Clinical Rheumatology - May 14, 2021 Category: Rheumatology Source Type: research

Dysregulated microRNA expression in rheumatoid arthritis families —a comparison between rheumatoid arthritis patients, their first-degree relatives, and healthy controls
ConclusionsWe confirm that microRNAs seem to be involved in the development of RA, and that the expression pattern in FDR is partly overlapping with RA patients. The contribution of single microRNAs in relation to the complex network including all microRNAs and other molecules is still to be revealed.Key Points• Expression levels of miR-22-3p, miR-26b-5p, miR-142-3p, and miR-155 were significantly altered in RA patients compared to those in controls.• In first-degree relatives, a significant trend with an intermediate microRNA expression in FDR was observed for the same four microRNAs. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - May 14, 2021 Category: Rheumatology Source Type: research

Anti-phospholipid syndrome leading to digital ischaemia and rare organ complications in systemic sclerosis and related disorders
We describe 5 cases that highlight the varied breadth of clinical manifestations of APS in the context of SSc and related disorders. These cases range from uncomplicated Raynaud ’s phenomenon, digital ulceration/necrosis, critical digital ischaemia/gangrene and rare internal organ complications of APS in SSc-spectrum disorders. To our knowledge, our cases include the first reported case of secondary APS contributing to digital necrosis in the context of RACAND syndrome (R aynaud’s phenomenon, anti-centromere antibodies and necrosis of the digits) and the first reported case of secondary APS in SSc causing poste...
Source: Clinical Rheumatology - May 14, 2021 Category: Rheumatology Source Type: research

Anti-vinculin antibodies in scleroderma (SSc): a potential link between autoimmunity and gastrointestinal system involvement in two SSc  cohorts
AbstractBackgroundSystemic sclerosis (SSc) is an autoimmune disorder and commonly presents with vascular system involvement and motility disorders in the gastrointestinal (GI) tract. Vinculin is a cytoskeletal protein that plays major roles in cell-cell adhesion and is expressed in the neuromuscular apparatus of the gut. Antibodies to vinculin have been identified as a biomarker of irritable bowel syndrome (IBS). Our aim was to evaluate serum anti-vinculin antibodies in patients with SSc.MethodsPatients were recruited from two SSc centers: group I (GI-enriched group), University of Leeds, UK, and Group II (vascular predomi...
Source: Clinical Rheumatology - May 14, 2021 Category: Rheumatology Source Type: research

Postpartum depression in Mexican women with autoimmune rheumatic diseases
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - May 14, 2021 Category: Rheumatology Source Type: research