Long COVID from rheumatology perspective — a narrative review
AbstractLong-term sequel of acute COVID-19, commonly referred to as long COVID, has affected millions of patients worldwide. Long COVID patients display persistent or relapsing and remitting symptoms that include fatigue, breathlessness, cough, myalgia, arthralgia, sleep disturbance, cognitive impairment and skin rashes. Due to the shared clinical features, laboratory and imaging findings, long COVID could mimic rheumatic disease posing a diagnostic challenge. Our comprehensive literature review will help rheumatologist to be aware of long COVID manifestations and differentiating features from rheumatic diseases to ensure ...
Source: Clinical Rheumatology - January 22, 2022 Category: Rheumatology Source Type: research

Osteitis condensans ilii: prevalence and characteristics of a neglected mimic of sacroiliitis
ConclusionsThe prevalence of OCI observed in our study is consistent with previous literature, and we confirm that it is more frequently retrieved in women. Longitudinal research is warranted to elucidate the evolution, while knowledge about the disorder is needed to raise the awareness of rheumatologists and radiologists and to properly identify and report the condition.Key Points• OCI may mimic sacroiliitis and is a major differential diagnosis of radiographic axial spondyloarthritis.• Prevalence of OCI in our sample is 1.0%, in line with previous literature.• OCI predominantly affects women, and our study...
Source: Clinical Rheumatology - January 22, 2022 Category: Rheumatology Source Type: research

The presence of rheumatological conditions is not a risk factor of long-term post-COVID symptoms after SARS-CoV-2 infection: a multicenter study
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 22, 2022 Category: Rheumatology Source Type: research

Three-dimensional ultrasonographic imaging of Mikulicz ’s disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 22, 2022 Category: Rheumatology Source Type: research

Exploring cannabis use and perspectives among psoriatic disease patients
ConclusionA third of the patients used cannabis within the past year, and 54.3% of users reported the use of cannabis for arthritis pain relief. However, there was no difference in pain scores. Comprehensive education for providers on the current body of evidence and further studies on cannabis use and outcomes in psoriatic disease are needed.Key Points• A third of patients with psoriatic arthritis have used cannabis in the past year.• Most used it for better sleep and control of pain.• There was no difference in pain scores between users and non-users.• IL-23 levels were significantly higher in non-use...
Source: Clinical Rheumatology - January 20, 2022 Category: Rheumatology Source Type: research

Psoriatic arthritis with hyperuricemia: more peripheral, destructive, and challenging to treat
ConclusionPatients with hyperuricemic PsA show poorer response to PsA treatment and have more peripheral and destructive joint damage than normo-uricemic patients.Key Points•Gout and psoriatic arthritis (PsA) can co-exist in the same patient.•Monosodium urate crystals might have a deleterious impact on PsA.•Hyperuricemic PsA is more polyarticular, less frequently axial, and more destructive than normo-uricemic PsA.•PsA with hyperuricemia should lead to more personalized medicine. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 20, 2022 Category: Rheumatology Source Type: research

Asymptomatic SARS-CoV-2 seropositivity: patients with childhood-onset rheumatic diseases versus healthy children
ConclusionWe revealed that patients with childhood-onset rheumatic diseases, even if they receive immunosuppressive medication such as biologic or conventional disease-modifying anti-rheumatic drugs, might have an asymptomatic SARS-CoV-2 infection, similarly to their healthy peers.Key points•Although it has been already known that children are most likely to have asymptomatic SARS-CoV-2 infection, there is a lack of data on the disease course of children with rheumatic disease.•There was no significant difference regarding the asymptomatic SARS-CoV-2 seropositivity rates between healthy children and the patients ...
Source: Clinical Rheumatology - January 19, 2022 Category: Rheumatology Source Type: research

Bone mineral density, vitamin D receptor (VDR) gene polymorphisms, fracture risk assessment (FRAX), and trabecular bone score (TBS) in rheumatoid arthritis patients: connecting pieces of the puzzle
AbstractPurposeTo assess vitamin D receptor (VDR) gene polymorphisms and bone mineral density and to investigate the possible risk factors of osteoporosis and fracture in rheumatoid arthritis (RA).MethodsA total of 97 RA patients and 45 matched controls were enrolled. Serum vitamin D level, VDR genotyping, dual-energy X-ray absorptiometry (DEXA) scan, trabecular bone score (TBS), and fracture risk assessment (FRAX) in 10  years were assessed. Disease activity score (DAS28) and modified health assessment questionnaire (MHAQ) were measured.ResultsThe mean age of the patients was 47.9  ± 8.9 yea...
Source: Clinical Rheumatology - January 19, 2022 Category: Rheumatology Source Type: research

Importance of baseline musculoskeletal ultrasound findings in the prognosis of rheumatoid arthritis
AbstractObjectivesTo investigate the prognostic value of baseline musculoskeletal ultrasound (MSUS) findings for rheumatoid arthritis (RA).MethodWe retrospectively analyzed 138 patients with RA. Patients ’ first MSUS record was considered as the baseline expression. The subsequent MSUS changes that showed alleviation or progression were regarded as the cutoff point. Grayscale ultrasound (GSUS) synovitis, power Doppler ultrasound (PDUS) synovitis, PDUS tenosynovitis (TS), and bone erosion were scor ed using a semi-quantitative scale. According to the ultrasound (US) results of the cutoff point, patients were divided i...
Source: Clinical Rheumatology - January 18, 2022 Category: Rheumatology Source Type: research

Clinical phenotype and cytokine profile of adult IgA vasculitis with joint involvement
ConclusionJoint involvement is frequent in adult IgAV and is associated with more frequent gastrointestinal involvement. Increased plasma IL-1 β levels raise the question of targeting this cytokine in patients with chronic and/or refractory joint involvement.Key Points• Joint involvement in adult IgAV is a frequent manifestation.• Joint involvement is associated with more frequent gastrointestinal manifestations.• Interleukin-1β (IL-1β) might orchestrate joint inflammation in adult IgAV.• IL-1β might be a therapeutic target in patients with chronic and/or refractory joint involvement...
Source: Clinical Rheumatology - January 18, 2022 Category: Rheumatology Source Type: research

New-onset Adult-onset Still ’s disease-like syndrome after ChAdOx1 nCoV-19 vaccination—a case series with review of literature
We report a series of 3 Adult-onset Still ’s disease (AOSD)-like presentations in previously healthy females following vaccination with the ChAdOx1 nCoV-19 vaccine, and also compare them with similar cases reported in literature through a PubMed database search. Our first patient had a high spiking bi-quotidian type of fever with myalgia, sore throat, and arthritis with onset 10-day post-vaccination, with laboratory features of hyper inflammation responding to only naproxen. She was off treatment after 2 months. The second patient, with onset 3-week post-vaccination, had a more severe illness, requiring high dos...
Source: Clinical Rheumatology - January 18, 2022 Category: Rheumatology Source Type: research

Quantitative CT analysis of interstitial pneumonia in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: a single center, retrospective study
This study aimed to assess the utility of quantitative high-resolution computed tomography (HRCT) for determining the clinical course of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis-associated interstitial lung disease (MDA5+ ILD).MethodThis study retrospectively analyzed the data of 34 patients with MDA5+ ILD to determine the association between the clinical findings and extent of ILD via quantitative CT analysis at baseline and short-term follow-up. Quantified HRCT scores were evaluated as the lung severity score (LSS), percentage of opacity, and percentage of high opacity.ResultsThir...
Source: Clinical Rheumatology - January 16, 2022 Category: Rheumatology Source Type: research

Dysfunction of CD27+IgD+ B cells correlates with aggravated systemic lupus erythematosus
AbstractObjectiveThe apoptotic signaling pathway is obviously disordered in systemic lupus erythematosus (SLE). Natural IgM (nIgM) is important in clearing apoptotic cells and preventing them from triggering deleterious autoimmunity. B-1 and innate-like B (ILBs) cells are the main nIgM producers. Human CD27+IgD+ B cells (un-switched memory B cells) are considered ILBs. However, their functional properties in SLE remain undefined.MethodsPeripheral blood sample of 50 SLE patients and 50 healthy controls were collected, and twelve SLE patients were assessed in a follow-up study. The amount of CD27+IgD+ B cell in each populati...
Source: Clinical Rheumatology - January 15, 2022 Category: Rheumatology Source Type: research

Rheumatoid arthritis and myasthenia gravis: a case-based review of the therapeutic options
ConclusionsAlthough the available evidence remains scarce, we consider glucocorticoids, methotrexate, and rituximab as safe and effective options. The role of tumor-necrosis factor inhibitors remains uncertain. Eventually, Janus Kinase inhibitors are a novel interesting option for these patients.Key Points•To date, the only evidence on the treatment of patients with rheumatoid arthritis and concomitant myasthenia gravis derives from case reports.•Based on the review of the available case reports and on the cases we described, we consider glucocorticoids, methotrexate, and rituximab as safe and effective options, ...
Source: Clinical Rheumatology - January 14, 2022 Category: Rheumatology Source Type: research

Annexin A1 and its receptor gene polymorphisms in systemic lupus erythematosus in the Tunisian population
ConclusionOur study showed an association betweenANXA1 >  rs3739959,FPR1 >  rs867228,FPR2 >  rs11666254,FPR2 >  rs17694990 and SLE susceptibility. Our results also showed a strong association between the two ANXA1 studied SNPs and LN which allowed us to suggest these two SNPs as biomarkers of LN development in SLE. Further research is needed to understand by which mechanism the gene variants affect suscept ibility to SLE.Key Points•Lupus erythematosus is an autoimmune disease in which a panoply of factors are implicated•Annexin A1 interaction wit...
Source: Clinical Rheumatology - January 14, 2022 Category: Rheumatology Source Type: research

Validation of the psoriasis epidemiology screening tool (PEST) and the new early arthritis for psoriatic patients (EARP) in pediatric population: pilot study
ConclusionBoth the PEST and EARP questionnaires were easy to use and had high sensitivity for the diagnosis of JPsA in the pediatric population with psoriasis. The PEST questionnaire had a higher specificity than the EARP.Key Points• EARP and PEST are good screening tools for diagnosis of arthritis in pediatric population with psoriasis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 14, 2022 Category: Rheumatology Source Type: research

The manifestation of myositis in tick-borne encephalitis as a prophet of severe disease course: a rare case report
AbstractTick-borne encephalitis (TBE) is one of the most serious neurological tick-transmitted diseases. The initial phase usually occurs with non-specific symptoms such as fever, headache, and muscular pain. The clinical spectrum of the second phase of the disease typically ranges from mild meningitis to severe meningoencephalitis. Our case demonstrates a rare clinical case of acute myositis as manifestation of TBE virus infection. A 33-year-old female was admitted to the Rheumatology centre with a fever followed by proximal muscle pain and weakness. Despite the tick bite history and marginally positive anti-TBE virus IgM...
Source: Clinical Rheumatology - January 13, 2022 Category: Rheumatology Source Type: research

Risk factors for progression of interstitial lung disease in Sj ögren’s syndrome
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 13, 2022 Category: Rheumatology Source Type: research

Fetal exposure to canakinumab: a report of three pregnancies
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 12, 2022 Category: Rheumatology Source Type: research

Illness perception and treatment experience in patients with gout: a descriptive qualitative study
ConclusionThere is a gap between patients ’ anticipation and practical service that is closely linked with subsequent poor gout management among the participants. The findings indicate a need of strengthening health education about gout by considering building nurse-led support groups and developing mobile health applications, as well as addressing the long-term influence of the Chinese alcoholic drinking culture to promote patients’ effective disease management.Key Points• This qualitative study fills a knowledge gap on illness perception and treatment experience among Chinese gout patients, exploring how...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Many people admitted to hospital with a provisional diagnosis of nonserious back pain are subsequently found to have serious pathology as the underlying cause
AbstractTo determine the proportion of patients admitted to the hospital for back pain who have nonserious back pain, serious spinal, or serious other pathology as their final diagnosis. The proportion of nonserious back pain admissions will be used to plan for future ‘virtual hospital’ admissions. Electronic medical record data between January 2016 and September 2020 from three emergency departments (ED) in Sydney, Australia were used to identify inpatient admissions. SNOMED-CT-AU diagnostic codes were used to select ED patients aged 18 and older with an adm itting diagnosis related to nonserious back pain. Th...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Serum levels of fetuin-A as a novel biomarker for disease activity in patients with Takayasu arteritis and granulomatous polyangiitis
ConclusionOur results suggest that serum Fet-A level could be a novel biomarker for assessment of activity status in patients with GPA or TA.Key Points•Serum Fetuin-A is negative acute phase protein and systemic calcification inhibitor synthesized in hepatocytes and secreted by various inflammation.•Serum Fetuin-A was negatively correlated with CRP, BVAS, and ITAS scores and significantly decreased in vasculitis patients with high disease activity.•Serum Fetuin-A could be a promising and useful biomarker for the assessment of disease activity for vasculitis, also that it might also be a predictor of long-ter...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Cardiac manifestations in primary antiphospholipid syndrome and their association to antiphospholipid antibodies ’ types and titers—cross-sectional study of Serbian cohort
ConclusionsCertain cardiac manifestations in PAPS were related to certain aPL type and/or titer levels, imposing confirmation in prospective studies. Preventive actions, comprehending proper anticoagulant/antithrombotic therapy, and intense action against standard atherosclerotic risk factors are of utmost importance in this group of patients.Key Points•In Serbian patients with primary antiphospholipid syndrome (PAPS), prevalence of non-criteria cardiac manifestations was 19.6% and they were significantly related to certain antiphospholipid antibodies and titers.•Lupus anticoagulant was a meaningful predictor of ...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Illness perception and treatment experience in patients with gout: a descriptive qualitative study
ConclusionThere is a gap between patients ’ anticipation and practical service that is closely linked with subsequent poor gout management among the participants. The findings indicate a need of strengthening health education about gout by considering building nurse-led support groups and developing mobile health applications, as well as addressing the long-term influence of the Chinese alcoholic drinking culture to promote patients’ effective disease management.Key Points• This qualitative study fills a knowledge gap on illness perception and treatment experience among Chinese gout patients, exploring how...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Many people admitted to hospital with a provisional diagnosis of nonserious back pain are subsequently found to have serious pathology as the underlying cause
AbstractTo determine the proportion of patients admitted to the hospital for back pain who have nonserious back pain, serious spinal, or serious other pathology as their final diagnosis. The proportion of nonserious back pain admissions will be used to plan for future ‘virtual hospital’ admissions. Electronic medical record data between January 2016 and September 2020 from three emergency departments (ED) in Sydney, Australia were used to identify inpatient admissions. SNOMED-CT-AU diagnostic codes were used to select ED patients aged 18 and older with an adm itting diagnosis related to nonserious back pain. Th...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Serum levels of fetuin-A as a novel biomarker for disease activity in patients with Takayasu arteritis and granulomatous polyangiitis
ConclusionOur results suggest that serum Fet-A level could be a novel biomarker for assessment of activity status in patients with GPA or TA.Key Points•Serum Fetuin-A is negative acute phase protein and systemic calcification inhibitor synthesized in hepatocytes and secreted by various inflammation.•Serum Fetuin-A was negatively correlated with CRP, BVAS, and ITAS scores and significantly decreased in vasculitis patients with high disease activity.•Serum Fetuin-A could be a promising and useful biomarker for the assessment of disease activity for vasculitis, also that it might also be a predictor of long-ter...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

Cardiac manifestations in primary antiphospholipid syndrome and their association to antiphospholipid antibodies ’ types and titers—cross-sectional study of Serbian cohort
ConclusionsCertain cardiac manifestations in PAPS were related to certain aPL type and/or titer levels, imposing confirmation in prospective studies. Preventive actions, comprehending proper anticoagulant/antithrombotic therapy, and intense action against standard atherosclerotic risk factors are of utmost importance in this group of patients.Key Points•In Serbian patients with primary antiphospholipid syndrome (PAPS), prevalence of non-criteria cardiac manifestations was 19.6% and they were significantly related to certain antiphospholipid antibodies and titers.•Lupus anticoagulant was a meaningful predictor of ...
Source: Clinical Rheumatology - January 11, 2022 Category: Rheumatology Source Type: research

The incidence, risk factor, and time to develop rheumatologic diseases after isolated inflammatory eye diseases: a 12-year cohort study
AbstractObjectiveThe incidence, risk factors, and time to diagnosis of rheumatologic disease (RD) in patients with isolated inflammatory eye diseases (IED) were investigated.Material and methodsA 12-year bidirectional cohort study was conducted in IED patients who were tested for antinuclear antibody (ANA) and rheumatoid factor (RF). Patients with prior RD were excluded. Impacts of relevant symptoms, signs, and laboratory investigations were analyzed.ResultsSeventy-five patients presented with IED including scleritis, anterior uveitis (AU), retinal vasculitis (RV), keratopathy, and optic neuritis (OP). AU, RV, keratopathy,...
Source: Clinical Rheumatology - January 10, 2022 Category: Rheumatology Source Type: research

Incidence and risk factors for vertebral fracture in rheumatoid arthritis: an update meta-analysis
ConclusionsOverall, our study demonstrated an increased risk of VF in patients with RA, suggesting that age, race, BMI, disease activity, and drug therapy may be represented as risk factors contributing to the occurrence of VF in RA.Key Points• RA patients had the increased prevalence and risk of vertebral fracture (VF) as compared to healthy population.• Age, race, BMI, disease activity, and drug therapy might be associated with VF in RA.• Our findings would be helpful for the early evaluation of RA patients with high VF risk. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 10, 2022 Category: Rheumatology Source Type: research

The incidence, risk factor, and time to develop rheumatologic diseases after isolated inflammatory eye diseases: a 12-year cohort study
AbstractObjectiveThe incidence, risk factors, and time to diagnosis of rheumatologic disease (RD) in patients with isolated inflammatory eye diseases (IED) were investigated.Material and methodsA 12-year bidirectional cohort study was conducted in IED patients who were tested for antinuclear antibody (ANA) and rheumatoid factor (RF). Patients with prior RD were excluded. Impacts of relevant symptoms, signs, and laboratory investigations were analyzed.ResultsSeventy-five patients presented with IED including scleritis, anterior uveitis (AU), retinal vasculitis (RV), keratopathy, and optic neuritis (OP). AU, RV, keratopathy,...
Source: Clinical Rheumatology - January 10, 2022 Category: Rheumatology Source Type: research

Incidence and risk factors for vertebral fracture in rheumatoid arthritis: an update meta-analysis
ConclusionsOverall, our study demonstrated an increased risk of VF in patients with RA, suggesting that age, race, BMI, disease activity, and drug therapy may be represented as risk factors contributing to the occurrence of VF in RA.Key Points• RA patients had the increased prevalence and risk of vertebral fracture (VF) as compared to healthy population.• Age, race, BMI, disease activity, and drug therapy might be associated with VF in RA.• Our findings would be helpful for the early evaluation of RA patients with high VF risk. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 10, 2022 Category: Rheumatology Source Type: research

Expert recommendations on early diagnosis and referral of axial spondyloarthritis in the Kingdom of Saudi Arabia
AbstractAxial spondyloarthritis is a chronic inflammatory disorder that primarily involves the axial skeleton (sacroiliac joints and spine), causing stiffness, severe pain and fatigue. In some patients, definitive structural damage of sacroiliac joints is visible on imaging and is known as radiographic axial spondyloarthritis. Some patients do not have a clear radiographic damage of the sacroiliac joints, and this subtype is known as non-radiographic axial spondyloarthritis. Early diagnosis is important for reducing the risk of irreversible structural damage and disability. Management of axial spondyloarthritis is challeng...
Source: Clinical Rheumatology - January 8, 2022 Category: Rheumatology Source Type: research

Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis
ConclusionsOur analysis suggested a causal association between genetically increased plasma omega-3 levels and the increased risk of RA in populations with European ancestry. Thus, to reduce the risk of RA, those of European descent should reduce omega-3 intake.Key Points• No significant pleiotropy or heterogeneity among the omega-3 genetic IVs in RA GWAS datasets.• Genetically increased plasma omega-3 levels enhanced the risk of RA in European lineages. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 8, 2022 Category: Rheumatology Source Type: research

Expert recommendations on early diagnosis and referral of axial spondyloarthritis in the Kingdom of Saudi Arabia
AbstractAxial spondyloarthritis is a chronic inflammatory disorder that primarily involves the axial skeleton (sacroiliac joints and spine), causing stiffness, severe pain and fatigue. In some patients, definitive structural damage of sacroiliac joints is visible on imaging and is known as radiographic axial spondyloarthritis. Some patients do not have a clear radiographic damage of the sacroiliac joints, and this subtype is known as non-radiographic axial spondyloarthritis. Early diagnosis is important for reducing the risk of irreversible structural damage and disability. Management of axial spondyloarthritis is challeng...
Source: Clinical Rheumatology - January 8, 2022 Category: Rheumatology Source Type: research

Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis
ConclusionsOur analysis suggested a causal association between genetically increased plasma omega-3 levels and the increased risk of RA in populations with European ancestry. Thus, to reduce the risk of RA, those of European descent should reduce omega-3 intake.Key Points• No significant pleiotropy or heterogeneity among the omega-3 genetic IVs in RA GWAS datasets.• Genetically increased plasma omega-3 levels enhanced the risk of RA in European lineages. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 8, 2022 Category: Rheumatology Source Type: research

Analysis of children with Henoch –Schonlein purpura secondary to infection
AbstractObjectivesHenoch –Schonlein purpura (HSP) is the most common childhood vasculitis, infection is the most essential inducement. We hypothesized that infection could impact the blood routine characteristics and/or outcome of vasculitis. Thus, we aim to find the most common infectious agent in HSP patients and identi fy convenient indicators to predict renal involvement in HSP patients with infection.MethodWe conducted a retrospective study of 208 HSP children and 98 healthy children. Clinical parameters were compared in those cases.ResultsA total of 68.75% of patients were infected with various pathogens. The m...
Source: Clinical Rheumatology - January 7, 2022 Category: Rheumatology Source Type: research

Effect of JAK inhibitors on high- and low-density lipoprotein in patients with rheumatoid arthritis: a systematic review and network meta-analysis
ConclusionsOur analysis suggests that, at their recommended doses, all five JAK inhibitors lead to an increase in HDL and LDL levels in RA patients. Further long-term research is required to extend these results and understand whether changes in lipid levels in RA patients can affect cardiovascular risk.Key Points• This is the first systematic review and NMA examining the effect of all five clinically approved JAK inhibitors on lipid levels in RA patients.• Recommended doses of JAK inhibitors used for the treatment of RA patients can induce a significant increase in HDL and LDL levels.• Indirect pairwise com...
Source: Clinical Rheumatology - January 7, 2022 Category: Rheumatology Source Type: research

Explaining the gap in the experience of depression among arthritis patients
ConclusionFindings suggest that the absence of paid sick leave is a key determinant for experiencing depressive symptoms among individuals with arthritis. The provision of paid sick leave may reduce report of depressive symptoms among employed arthritis patients in the USA.Key Points• Individuals with arthritis are consistently at greater risk of depression and unemployment as compared to individuals without arthritis.• To date greater emphasis is put on determinants of unemployment, while there is no available data on benefits associated with being employed, such as sick leave, and how it affects mental health.&...
Source: Clinical Rheumatology - January 7, 2022 Category: Rheumatology Source Type: research

Analysis of children with Henoch –Schonlein purpura secondary to infection
AbstractObjectivesHenoch –Schonlein purpura (HSP) is the most common childhood vasculitis, infection is the most essential inducement. We hypothesized that infection could impact the blood routine characteristics and/or outcome of vasculitis. Thus, we aim to find the most common infectious agent in HSP patients and identi fy convenient indicators to predict renal involvement in HSP patients with infection.MethodWe conducted a retrospective study of 208 HSP children and 98 healthy children. Clinical parameters were compared in those cases.ResultsA total of 68.75% of patients were infected with various pathogens. The m...
Source: Clinical Rheumatology - January 7, 2022 Category: Rheumatology Source Type: research

Effect of JAK inhibitors on high- and low-density lipoprotein in patients with rheumatoid arthritis: a systematic review and network meta-analysis
ConclusionsOur analysis suggests that, at their recommended doses, all five JAK inhibitors lead to an increase in HDL and LDL levels in RA patients. Further long-term research is required to extend these results and understand whether changes in lipid levels in RA patients can affect cardiovascular risk.Key Points• This is the first systematic review and NMA examining the effect of all five clinically approved JAK inhibitors on lipid levels in RA patients.• Recommended doses of JAK inhibitors used for the treatment of RA patients can induce a significant increase in HDL and LDL levels.• Indirect pairwise com...
Source: Clinical Rheumatology - January 7, 2022 Category: Rheumatology Source Type: research

Explaining the gap in the experience of depression among arthritis patients
ConclusionFindings suggest that the absence of paid sick leave is a key determinant for experiencing depressive symptoms among individuals with arthritis. The provision of paid sick leave may reduce report of depressive symptoms among employed arthritis patients in the USA.Key Points• Individuals with arthritis are consistently at greater risk of depression and unemployment as compared to individuals without arthritis.• To date greater emphasis is put on determinants of unemployment, while there is no available data on benefits associated with being employed, such as sick leave, and how it affects mental health.&...
Source: Clinical Rheumatology - January 7, 2022 Category: Rheumatology Source Type: research

Genotype –phenotype associations in familial Mediterranean fever: a study of 500 Egyptian pediatric patients
ConclusionThis study encompasses the largest group of Egyptian pediatric FMF up to date to explore their genotype –phenotype associations. Our results support the notion that the genotype influences the phenotype as regards clinical manifestations, disease severity, and colchicine response.Key Points:• This study encompasses the largest group of Egyptian pediatric patients affected by FMF up to date to explore their genotype–phenotype associations.• Our results support the notion that the genotype influences the phenotype as regards the clinical manifestations, the disease severity, and the response t...
Source: Clinical Rheumatology - January 6, 2022 Category: Rheumatology Source Type: research

The disease burden of axial spondyloarthritis: through a gendered lens
ConclusionsaxSpA adversely impacts HRQoL regardless of gender, but women seeking care for axSpA may experience greater challenges reaching a diagnosis. It is essential that providers recognize impaired HRQoL among men and women with axSpA. Future studies with larger sample sizes are needed to identify aspects of HRQoL to adequately address people with axSpA.Key Points•While men waited on average a year longer to tell their healthcare provider about their symptoms, the diagnostic delay is 2 years longer for women.•Women and men with axSpA have similar experiences regarding impacts on their health-related quality o...
Source: Clinical Rheumatology - January 6, 2022 Category: Rheumatology Source Type: research

Indications and risk factors for hospitalization in patients with primary Sj ögren syndrome: experience from a tertiary center in Turkey
In this study, it was aimed to reveal the hospitalization reasons for patients diagnosed with primary Sj ögren syndrome (pSS) and potentially associated factors in a tertiary health center.MethodOne hundred and sixty-three pSS patients who regularly attended their follow-ups between January 2010 and May 2021 were included in the study. These patients ’ reasons for hospitalization, duration of hospitalization, and numbers of presenting to the hospital were recorded. The demographic, clinical and serological characteristics of the hospitalized and non-hospitalized patients were compared.ResultsHospitalization occu...
Source: Clinical Rheumatology - January 6, 2022 Category: Rheumatology Source Type: research

Genotype –phenotype associations in familial Mediterranean fever: a study of 500 Egyptian pediatric patients
ConclusionThis study encompasses the largest group of Egyptian pediatric FMF up to date to explore their genotype –phenotype associations. Our results support the notion that the genotype influences the phenotype as regards clinical manifestations, disease severity, and colchicine response.Key Points:• This study encompasses the largest group of Egyptian pediatric patients affected by FMF up to date to explore their genotype–phenotype associations.• Our results support the notion that the genotype influences the phenotype as regards the clinical manifestations, the disease severity, and the response t...
Source: Clinical Rheumatology - January 6, 2022 Category: Rheumatology Source Type: research

The disease burden of axial spondyloarthritis: through a gendered lens
ConclusionsaxSpA adversely impacts HRQoL regardless of gender, but women seeking care for axSpA may experience greater challenges reaching a diagnosis. It is essential that providers recognize impaired HRQoL among men and women with axSpA. Future studies with larger sample sizes are needed to identify aspects of HRQoL to adequately address people with axSpA.Key Points•While men waited on average a year longer to tell their healthcare provider about their symptoms, the diagnostic delay is 2 years longer for women.•Women and men with axSpA have similar experiences regarding impacts on their health-related quality o...
Source: Clinical Rheumatology - January 6, 2022 Category: Rheumatology Source Type: research

Indications and risk factors for hospitalization in patients with primary Sj ögren syndrome: experience from a tertiary center in Turkey
In this study, it was aimed to reveal the hospitalization reasons for patients diagnosed with primary Sj ögren syndrome (pSS) and potentially associated factors in a tertiary health center.MethodOne hundred and sixty-three pSS patients who regularly attended their follow-ups between January 2010 and May 2021 were included in the study. These patients ’ reasons for hospitalization, duration of hospitalization, and numbers of presenting to the hospital were recorded. The demographic, clinical and serological characteristics of the hospitalized and non-hospitalized patients were compared.ResultsHospitalization occu...
Source: Clinical Rheumatology - January 6, 2022 Category: Rheumatology Source Type: research

Comment on: Can Raynaud ’s phenomenon be defined as a subtype of primary Sjögren’s syndrome? Comments on “Clinical features and risk factors of Raynaud’s phenomenon in primary Sjögren’s syndrome” Reply
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 4, 2022 Category: Rheumatology Source Type: research