Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study
AbstractObjectivesTo determine the prevalence of clinical manifestations and incidence rate of cardiopulmonary complications in a comparison between men and women with early SSc.MethodsAn inception cohort of early-SSc patients at the Rheumatology Clinic, Maharaj Nakorn Chiang Mai Hospital, between January 2010 and June 2016, was used. All patients were assessed for clinical manifestations and underwent ECG, echocardiography, and HRCT at the study entry and then annually.ResultsOne hundred and fifteen patients (46 male, 90  dcSSc) with a mean (SD) disease duration of 11.6 months (8.8) at cohort entry were enrolled...
Source: Clinical Rheumatology - April 19, 2019 Category: Rheumatology Source Type: research

Oral health –related quality of life among individuals with rheumatoid arthritis
ConclusionRA individuals had a more negative perception of their OHRQoL compared with individuals with no RA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 19, 2019 Category: Rheumatology Source Type: research

Elusive trochanteric bursitis relief
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 19, 2019 Category: Rheumatology Source Type: research

Causes of fetal third-degree atrioventricular block and use of hydroxychloroquine in pregnant women with Ro/La antibodies
ConclusionsAll congenital AVB diagnosed at our hospital without cardiac malformations were associated with a maternal rheumatologic disease/antibodies. Therefore, if a AVB is diagnosed in a newborn without structural heart disease, the mother should be studied for an autoimmune disease. We found a high prevalence of AVB among mothers with anti-Ro/La antibodies. Although not statistically significant, AVBs in mothers with Ro/La antibodies were numerically more frequent in those not using hydroxychloroquine.Key Points• Although structural heart malformations were the predominant cause of third-degree AVB, autoimmune AVB...
Source: Clinical Rheumatology - April 17, 2019 Category: Rheumatology Source Type: research

Value of serum procalcitonin for the diagnosis of bacterial septic arthritis in daily practice in rheumatology
AbstractIntroduction/objectivesSeptic arthritis is a diagnostic and therapeutic emergency because of a high morbidity and mortality. Nevertheless, the etiologic diagnosis is often difficult. The aim of our study was to determine if serum procalcitonin was a discriminatory biomarker in case of arthritis of undetermined etiology.MethodPatients were separated in five groups: gouty arthritis, calcium pyrophosphate deposition arthritis, osteoarthritis or post-traumatic arthritis ( “mechanical” arthritis), chronic inflammatory rheumatic arthritis, and septic arthritis. Levels of serum white blood cells, C-reactive pr...
Source: Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research

Mortality in patients with systemic lupus erythematosus in Colombia: a case series
ConclusionThe main causes of death included SLE activity refractory to immunosuppressive treatment, and nosocomial bacterial infections. The patients who died had persistently high SLEDAI scores, types IV and VI LN, associated antiphospholipid syndrome, and persistent hypocomplementemia, requiring severe immunosuppression and prolonged hospitalization. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2019 Category: Rheumatology Source Type: research

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review
AbstractHypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. It has been reported to accompany certain infections such as hepatitis B, hepatitis C, infectious mononucleosis, and coxsackie group A. However, it has never bee...
Source: Clinical Rheumatology - April 13, 2019 Category: Rheumatology Source Type: research

Think autoimmunity, breath autoimmunity, and learn autoimmunity
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 12, 2019 Category: Rheumatology Source Type: research

A misdiagnosed case of antisynthetase syndrome complicated by myocarditis: when the cardiologist deals with rheumatology
We report a case of a 56-year-old woman with an alleged diagnosis of an acute coronary syndrome that was later correctly identified in our Cardiology Unit as antisynthetase syndrome (AS) with inflammatory cardiac involvement. In this case report, we focus on clinical features of this rare autoimmune disease aiming to provide useful tips to achieve correct differential diagnosis according to updated international guidelines and recommendations, especially in cases of concurrent disease-related myocarditis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 11, 2019 Category: Rheumatology Source Type: research

Seasonal variations of Google searches for joint swelling: implications for patient-reported outcomes
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 11, 2019 Category: Rheumatology Source Type: research

Correction to: Predictors of abatacept retention over 2 years in patients with rheumatoid arthritis: results from the real-world ACTION study
The article listed above was initially published with incorrect copyright information. Upon publication of this Correction, the copyright of this article changed to “The Author(s)”. The original article has been corrected. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 11, 2019 Category: Rheumatology Source Type: research

Validation of the Chinese version of joint protection self-efficacy scale in patients with rheumatoid arthritis
ConclusionThis is the first study to adapt and validate the JP-SES into Chinese for use in patients with RA. Our research showing that the CJP-SES has a good construct validity, internal consistency, and test –retest reliability. This scale can help doctors and nurses to assess the self-efficacy of patients with RA.Trial registrationClinicalTrials.gov Identifier: TJYY-YLS-036 (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 10, 2019 Category: Rheumatology Source Type: research

Infliximab for the treatment of refractory polyarteritis nodosa
We describe herein the patients ’ characteristics, clinical manifestations, severity and response to infliximab treatment and review the current literature. Complete remission was defined as the absence of features of active disease and withdrawal of prednisone therapy. Significant improvement was defined as clinical improvement and prednisone dose reduction of at least 50% or a 50% reduction in immune modulatory medications other than prednisone. After 4 months of treatment, 8/9 (89%) patients achieved significant improvement, with two of them achieving complete remission. We suggest that anti-TNF agents, and i...
Source: Clinical Rheumatology - April 10, 2019 Category: Rheumatology Source Type: research

Burden of comorbidities in South Africans with systemic lupus erythematosus
AbstractIntroductionTo investigate the prevalence and spectrum of comorbidities in South Africans with systemic lupus erythematosus (SLE).Patients and methodsA nested case-control study of a known alive group (AG) and deceased group (DG) of 200 and 40 patients, respectively, matched for age and sex, attending a tertiary Lupus Clinic. Comorbidities that were documented included, but not restricted to, those listed in the Charlson comorbidity index (CCI). Lupus disease severity was assessed using the lupus severity index (LSI).ResultsPatients were mainly black female (94%), and the median age (IQR) and median disease duratio...
Source: Clinical Rheumatology - April 8, 2019 Category: Rheumatology Source Type: research

Brief report: the disability of chronic chikungunya arthritis
AbstractIn 50% of patients, chikungunya fever (CHIKF) is followed by arthritic pain that is often chronic, painful, and disabling. To better define the spectrum of pain and disability in chronic CHIK arthritis (CCA), we evaluated 35 consecutive CCA patients seen in a Brazilian rheumatology clinic, using a pain Visual Analog Scale and the Health Assessment Questionnaire Disability Index. In our patients, pain and disability levels were of the same magnitude as are seen in other serious rheumatic diseases. The mean score for 19 patients with moderate disability was 1.42 ± 0.20 (median 1.37). The median HAQ-DI s...
Source: Clinical Rheumatology - April 8, 2019 Category: Rheumatology Source Type: research

Correction to: Risk of adverse outcomes in patients with rheumatoid arthritis hospitalized for stroke —a cross-sectional study
The authors of the published version of this article incorrectly presented the affiliation of Li-Chin Sung. The revised affiliation is now presented correctly in this article. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 6, 2019 Category: Rheumatology Source Type: research

Extractable synovial fluid in inflammatory and non-inflammatory arthritis of the knee
AbstractIntroduction/objectivesWe hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) would mobilize occult extractable fluid and improve arthrocentesis success.MethodsSixty-seven consecutive knees with RA and 186 knees with OA and were included. Conventional arthrocentesis was performed and success and volume (milliliters) determined; the needle was left intraarticularly, and mechanical compression was applied with an elastomeric knee brace. Arthrocentesis was then resumed until fluid return ceased. Fluid was characterized as to volume and cell counts.ResultsIn the RA, knee mechanical compres...
Source: Clinical Rheumatology - April 5, 2019 Category: Rheumatology Source Type: research

Ankle pain in rheumatoid arthritis: comparison of clinical and sonographic findings
AbstractTo describe the prevalence and distribution of clinical and ultrasound (US) pathological findings at ankle level and to compare them, in patients with rheumatoid arthritis (RA). This is a descriptive, cross-sectional study assessing patients diagnosed with RA according to the 2010 ACR criteria, who were recruited consecutively and independently of disease status or treatment and of the presence of pain at ankle level. Clinical and US findings were acquired by two independent rheumatologists. US assessments were performed according to the EULAR and OMERACT indications. A total of 224 ankles of 112 RA patients were e...
Source: Clinical Rheumatology - April 2, 2019 Category: Rheumatology Source Type: research

Incidence and risk factors of new-onset hypertrophic pachymeningitis in patients with anti-neutrophil antibody-associated vasculitis: using logistic regression and classification tree analysis
AbstractObjectivesHypertrophic pachymeningitis (HP) is a rare complication in patients with anti-neutrophil antibody-associated vasculitis (AAV); its clinical features, incidence, and risk factors remain unknown. We aimed to clarify the prevalence, clinical features, and factors associated with new-onset HP in patients with AAV.MethodA retrospective cohort study involving 93 patients with AAV was conducted. HP incidence between patients with granulomatosis with polyangiitis (GPA) and those with microscopic polyangiitis (MPA) was compared to investigate risk factors associated with HP. We performed only univariate analysis ...
Source: Clinical Rheumatology - March 19, 2019 Category: Rheumatology Source Type: research

Association between hyperuricemia and nontraditional adiposity indices
AbstractBackgroundThe association between several novel adiposity indices and hyperuricemia is inconclusive. Therefore, we aimed to investigate this association so as to provide theoretical support for the management of hyperuricemia in overweight/obese individuals.MethodsA cross-sectional study was carried out among 174,698 adults. The values of body adiposity index (BAI), conicity index (CI), a body shape index (ABSI), body roundness index (BRI), visceral adiposity index (VAI), lipid accumulation product (LAP) index, and cardiometabolic index (CMI) were divided into four quartiles, and multivariate logistic analysis was ...
Source: Clinical Rheumatology - March 19, 2019 Category: Rheumatology Source Type: research

Combined immunosuppressive treatment (CIST) in lupus nephritis: a multicenter, randomized controlled study
This study was aimed to seek higher remission rate of lupus nephritis using a combined strategy.MethodA 24-week trial was conducted in 17 rheumatology or nephrology centers in China. A total of 191 lupus nephritis patients were randomized to follow a combined immunosuppressive treatment (CIST) with intravenous cyclophosphamide, an oral immunosuppressive agent, namely mycophenolate mofetil, azathioprine or leflunomide, and hydroxychloroquine (n = 95), or receive intravenous cyclophosphamide alone (n = 96) for 24 weeks. Glucocorticoid was given to both groups. The primary end point was a comp...
Source: Clinical Rheumatology - March 19, 2019 Category: Rheumatology Source Type: research

Comparison Between INSPIRE and Domjan method for measuring lumbar lateral flexion in patients of psoriatic arthritis (PsA) and correlation with radiographic damage
ConclusionBoth INSPIRE and Domjan methods correlate well as measures of SLF in PsA and correlate with radiographic damage. Therefore, the simpler INSPIRE method may be used to measure SLF in PsA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 19, 2019 Category: Rheumatology Source Type: research

Podocytic infolding glomerulopathy: two new cases with connective tissue disease and literature review
We present two new cases of PIG with connective tissue disease (CTD), one with primary Sj ögren’s syndrome and the other with systemic lupus erythematosus (SLE), and make a systemic review of the literature. In the entire 31 patients of PIG, 24 (77.42%) were women and seven (22.58%) were men, with an average age of 41.2 ± 15.2 (ranging from 14 to 79) years old. Almost two-thirds of patients (67.74%) were diagnosed with CTD, in which 76.19% were SLE. All patients presented with proteinuria and six (19.35%) patients were accompanied with hematuria. Serum creatinine was elevated in six (19.35%)...
Source: Clinical Rheumatology - March 16, 2019 Category: Rheumatology Source Type: research

Risk factors of relapse in pulmonary sarcoidosis treated with corticosteroids
ConclusionsThis study provided useful information that the relapse and associated risk factors should be taken into considerations when determining treatment strategies for patients with pulmonary sarcoidosis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 15, 2019 Category: Rheumatology Source Type: research

Associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis patients, and comparison of PON1 activity in patients and controls: a meta-analysis
AbstractObjectivesWe reviewed the associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis (RA) patients and compared PON1 activity between RA patients and controls.MethodsWe conducted a meta-analysis of PON1 Q192R and L55M polymorphism and RA risk data and determined the associations between PON1 Q192R polymorphism and PON1 activity in RA patients. We also compared serum/plasma PON1 activity levels in RA patients and controls.ResultsTwelve studies were included in this meta-analysis. No association was observed between RA and the PON1 192R allele in any study sub...
Source: Clinical Rheumatology - March 13, 2019 Category: Rheumatology Source Type: research

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases
AbstractMycobacterium bovis Bacillus Calmette-Gu érin (BCG) instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. We made a review ofM. bovis BCG vertebral osteomyelitis after instillations for bladder cancer using PubMed search. We added three new French cases. Twenty-seven cases of BCG vertebral osteomyelitis had been reported on PubMed. Of the 30 cases, all were male, averaging 73.4  ± 8.7 years old. Median time between diagnosis a...
Source: Clinical Rheumatology - March 13, 2019 Category: Rheumatology Source Type: research

Serum interleukin-21 positivity could indicate the current activity of antineutrophil cytoplasmic antibody-associated vasculitis: a monocentric prospective study
AbstractInterleukin-21 (IL-21) is a pleotropic cytokine that plays an important role in the regulation of both innate and adaptive immune responses. In the present study, we investigated whether serum IL-21 positivity is associated with disease activity in patients with all variants of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Sixty patients with AAV from a monocentric prospective cohort were enrolled from November 2016 to May 2018 in this study. On the day of visit, clinical manifestations including Birmingham vasculitis activity score (BVAS) were assessed, routine laboratory tests were perfo...
Source: Clinical Rheumatology - March 12, 2019 Category: Rheumatology Source Type: research

The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies
ConclusionsPM/DM patients had high frequencies of MSAs. Several MSAs were independent factors in determining unique clinical phenotypes. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 12, 2019 Category: Rheumatology Source Type: research

Rebuttal letter to Dr. Fallahi ’s letter about our manuscript “Axial spondyloarthritis in the USA: diagnostic challenges and missed opportunities.” Clin Rheumatol. 2018 Dec 26. https://doi.org/10.1007/s10067-018-4397-3
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 12, 2019 Category: Rheumatology Source Type: research

Polymorphisms of human glucocorticoid receptor gene in systemic lupus erythematosus: a single-centre result
ConclusionThe increased and decreased sensitivity associated withGR BclI and A3669G polymorphisms could have a pathogenic significance in SLE especial with the central nervous system and psychiatric symptoms. Improving our knowledge on the importance ofGR polymorphisms may reveal their pathophysiologic and therapeutic consequences. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 9, 2019 Category: Rheumatology Source Type: research

Broad-range 16  s rDNA PCR in synovial fluid does not improve the diagnostic performance of septic arthritis in native joints in adults: cross-sectional single-center study in 95 patients
Conclusions16  s rDNA PCR in the synovial fluid does not improve the diagnostic performance of septic arthritis on native adult joints, particularly for Gram-positive cocci infections. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 8, 2019 Category: Rheumatology Source Type: research

Detection of rheumatoid arthritis from hand radiographs using a convolutional neural network
ConclusionUsing only pixel information on hand radiographs, a multi-layer CNN architecture with online data augmentation was designed. The performance metrics such as accuracy, error rate, sensitivity, specificity, and precision state shows that the network is promising in diagnosing rheumatoid arthritis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 8, 2019 Category: Rheumatology Source Type: research

Disease activity is associated with cognitive impairment in patients with rheumatoid arthritis
AbstractObjectiveTo investigate the association between disease activity and cognitive impairment in patients with rheumatoid arthritis (RA).MethodsA total of 464 patients from the rheumatoid arthritis registry of two academic centers, Siriraj and Phramongkutklao hospitals, were included. Demographic, clinical, and laboratory data related to disease activity and functional status were collected. Cognitive function was assessed using the Thai version of the Montreal Cognitive Assessment (MoCA-T). Subjects were classified as cognitively impaired if they scored less than 25.ResultsMost subjects (85%) were female with a mean a...
Source: Clinical Rheumatology - March 8, 2019 Category: Rheumatology Source Type: research

How much gloom is in groans? Depression and its determinants in Nigerian patients with knee osteoarthritis: a multi-center cross-sectional study
AbstractObjectivesTo determine the prevalence of depression and its determinants among Nigerian patients with knee osteoarthritis (OA).MethodsTwo hundred and fifty patients satisfying the American College of Rheumatology classification criteria for knee OA were recruited from five centers. Pain was assessed using Western Ontario and McMaster Universities Index (WOMAC) pain subscale, functional status was determined by Steinbrokers criteria, radiographic knee OA was graded using Kellgren –Lawrence criteria, depression was determined using the Patient Health Questionnaire (PHQ-9), sleep quality by the Pittsburgh Sleep ...
Source: Clinical Rheumatology - March 7, 2019 Category: Rheumatology Source Type: research

The efficacy and safety of antithrombotic therapy in patients with positive antiphospholipid antibodies receiving invasive procedures: experience from a single tertiary center
ConclusionsAggressive antithrombotic therapy was associated with fewer thrombotic events in aPL-positive patients receiving invasive procedures, but might contribute to an increased bleeding rate, especially in large open surgeries. This study justifies more caution in prophylactic antithrombotic therapy in periprocedural aPL-positive patients. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 7, 2019 Category: Rheumatology Source Type: research

Letter to the editor: “The association of CD40 polymorphism (rs1883832C/T) and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients”
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 7, 2019 Category: Rheumatology Source Type: research

Validation of Turkish version of the Scleroderma Health Assessment Questionnaire
The objective of this study was to perform an adaptation and validation of a Turkish version of the SHAQ.MethodWe validated psychometric properties of the scale with 70 consecutive systemic sclerosis (SSc) patients, who fulfilled the 2013 ACR/EULAR classification criteria for SSc. We evaluated test –retest reliability with the intraclass correlation coefficient (ICC), discriminant validity by stratifying patients according to organ involvements and disease subtypes, and convergent validity by testing the correlation between SHAQ and related components of Short Form 36 version 2 (SF-36v2). In ternal consistency of the...
Source: Clinical Rheumatology - March 6, 2019 Category: Rheumatology Source Type: research

Facilitating patient-centered care: the development of illustrated multidimensional patient-reported outcome measures for children/adolescents with juvenile idiopathic arthritis
AbstractObjectivesTo assess the validity, reliability, comprehensibility, and responsiveness to change of an illustrated child/parent  multidimensional patient-reported outcome measures (PROMs) questionnaire which can assess construct outcome measures of children with juvenile inflammatory arthritis.MethodsA total of 122 children with juvenile idiopathic arthritis were included in this work in a multicenter study. The questionnaire included seven categories: (1) functional ability; (2) health-related quality of life; (3) disease activity measures: pain, global assessment, fatigue, and morning stiffness; (4) self-rep...
Source: Clinical Rheumatology - March 5, 2019 Category: Rheumatology Source Type: research

MEFV gene mutations in children with Henoch –Schönlein purpura and their correlations—do mutations matter?
ConclusionHenoch –Schönlein purpura in patients with homozygous exon 10MEFV mutations seems to be more severe than that in patients carrying other mutations. In patients with exon 10MEFV mutations, Henoch –Schönlein purpura might be considered as an associated presentation of familial Mediterranean fever rather than a separate clinical entity.Key points•p.M694V mutation is more common in Henoch –Schönlein purpura than in the general population.•p.E148Q variants have no impact on clinical symptoms and laboratory findings in Henoch –Schönlein purpura patients.•The ma...
Source: Clinical Rheumatology - March 2, 2019 Category: Rheumatology Source Type: research

Detection of Familial Mediterranean Fever attacks by using a connected activity tracker and assessment of impact of attacks to daily physical activities: a pilot study
ConclusionsFMF attacks significantly impair the physical activity of patients. Activity tracking may be a reasonable method to document FMF attacks. This might prevent errors due to memory bias and help accurately identify and treat patients with FMF. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 2, 2019 Category: Rheumatology Source Type: research

Effects of interaction between varus thrust and ambulatory physical activity on knee pain in individuals with knee osteoarthritis: an exploratory study with 12-month follow-up
This study aimed to examine the interaction effect between ambulatory physical activity (PA) and varus thrust on knee pain in individuals with knee osteoarthritis (OA).MethodSubjects (n = 207; mean age: 73.1 years, 71.5% women) in orthopedic clinics with diagnosed knee OA (Kellgren/Lawrence grade ≥ 1) were enrolled in this 12-month observational cohort study. Participants underwent gait observation for varus thrust assessment and pedometer-based ambulatory PA measurements at baseline and 12-month follow-up. Knee pain intensity was assessed using the Japanese Knee Osteoarthritis Measure pain sub...
Source: Clinical Rheumatology - March 1, 2019 Category: Rheumatology Source Type: research

The association of CD40 polymorphism (rs1883832C/T) and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients
AbstractBackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disorder of unknown etiology. Considerable evidence supports a genetic basis for susceptibility to SLE. Genetic and functional data suggested the CD40 receptor (CD40) and CD40 ligand (CD40L) as strong candidate genes for SLE.AimTo investigate whether CD40 gene rs1883832 C/T single-nucleotide polymorphism (SNP) and/or soluble CD40 (sCD40) are associated with SLE in the Egyptian population.Subjects and methodsThe study included a hundred SLE patients, and a fifty age- and gender-matched healthy control subjects. CD40 gene rs1883832 C/T genotyping wa...
Source: Clinical Rheumatology - February 27, 2019 Category: Rheumatology Source Type: research

Evaluation of treatment adherence in patients with Beh çet’s disease: its relation to disease manifestations, patients’ beliefs about medications, and quality of life
AbstractIntroduction/objectivesDespite its importance, adherence to treatment has not been sufficiently studied in Beh çet’s disease (BD). The aim of this study was to evaluate medication adherence in BD using the Compliance Questionnaire of Rheumatology (CQR) and factors potentially affecting it.MethodThis cross-sectional study included 67 consecutive BD patients including 57 (85%) males with a mean age of 35.1  ± 9.27 years and mean disease duration of 129 ± 91 months. The cumulative clinical manifestations, the Behçet’s Disease Current Activit...
Source: Clinical Rheumatology - February 27, 2019 Category: Rheumatology Source Type: research

First-degree relatives of axial spondyloarthritis patients of the pre-SpA cohort would consider using medication in a preventive setting
AbstractTo study the willingness of first-degree relatives of axial spondyloarthritis (axSpA) patients to use preventive medication. First-degree relatives of HLA-B27-positive axSpA patients (pre-SpA cohort) (n = 106) completed a survey including scenarios varying in disease risk, side effects, and treatment effect of hypothetical preventive medication and questions about their perceived risk of developing SpA and assessment of the severity of SpA. The willingness to use preventive medication was 63.2 –91.5% (with 30–70% SpA risk, respectively) and declined to 27.4–51.9% respectively, when s...
Source: Clinical Rheumatology - February 27, 2019 Category: Rheumatology Source Type: research

Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis
This study provides further evidence of dysregulation of gene expression at various levels of the Wnt signaling pathway in dcSSc. Moreover, principal component analysis showed two distinct patient clusters of gene expression, which co-segregated with the presence or absence of clinical inflammatory features, and may reflect different pathological pathways in dcSSc. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 27, 2019 Category: Rheumatology Source Type: research

Neurosonological and cognitive screening for evaluation of systemic sclerosis patients
AbstractObjectiveAssessment of cerebrovascular hemodynamics, third ventricle diameter (as a proxy of brain atrophy) by transcranial sonography (TCS), and screening of cognitive performance by the Symbol Digit Modalities Test (SDMT) in systemic sclerosis (SSc) patients.MethodsA total of 38 SSc patients recruited from the outpatient clinic of the Rheumatology Department, Kasr Alainy Hospital, Cairo University, and 51, age- and sex-matched, healthy controls were included in the study. TCS was used to assess the mean flow velocity (MFV), pulsatility index (PI) of the anterior, middle, and posterior cerebral arteries bilaterall...
Source: Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Elevated circulating T cell subsets and cytokines expression in patients with rheumatoid arthritis
ConclusionsElevated circulating T cell subsets and cytokines expression profile were observed in RA patients. IL-6, MCP-1, and IL-1 β were significantly increased in RA, and PD1+ICOS+ TEM, PD1+ICOS+ TCM, and PD1+ICOS+ Tfh cell subsets were positively correlated with disease activity DAS28. Therefore, PD1+ICOS+ TEM, PD1+ICOS+ TCM, and PD1+ICOS+ Tfh cells might serve an important role in the progression of RA. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Prevalence of frailty and its associated factors in patients with rheumatoid arthritis: a cross-sectional analysis
AbstractObjectivesThe aims of the present research were to assess the prevalence of frailty and its potential associated factors in a cohort of adult patients with rheumatoid arthritis (RA).MethodsConsecutive RA patients and healthy controls were assessed according to the Survey of Health, Ageing and Retirement in Europe Frailty Instrument (SHARE-FI), and classified as frail, pre-frail, or non-frail. Chi-square, analysis of variance (ANOVA), and multinomial logistic regression analyses were used to test the prognostic value of frailty for the outcomes of interest.ResultsTwo hundred and ten consecutive RA patients (65.7% fe...
Source: Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

When brucellosis met the Assessment of SpondyloArthritis international Society classification criteria for spondyloarthritis: a comparative study
AbstractObjectivesTo distinguish brucellosis patients fulfilling the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for spondyloarthritis (SpA) from SpA patients.MethodsBrucellosis patients diagnosed from September 2012 to December 2017 who met the ASAS classification criteria for SpA were analyzed with clinical characteristics and laboratory and imaging examinations. Axial or peripheral SpA patients were respectively included into the comparative analysis with a 4:1 ratio.ResultsTwenty-two brucellosis (10 axial and 12 peripheral) patients (male, 16 cases; 72.72%; mean (S.D.) age, 40.2...
Source: Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Effect of flaxseed poultice compress application on pain and hand functions of patients with hand osteoarthritis
ConclusionsIn addition to pharmacological treatment, flaxseed poultice compress intervention is recommended to be used as a nursing intervention for reducing pain and increasing hand functions for patients with hand OA in cooperation with the physicians and other health professionals. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research