Hydroxychloroquine significantly decreases the risk of preeclampsia in pregnant women with autoimmune disorders: a systematic review and meta-analysis
AbstractThis meta-analysis aimed to investigate whether hydroxychloroquine (HCQ) intervention could decrease the incidence of preeclampsia and other maternal and fetal outcomes among pregnant women with autoimmune disorders. PubMed, EMBASE, Web of Science, and the Cochrane databases were searched from inception until January 2022. Data on maternal or fetal outcomes of the control and hydroxychloroquine treatment groups were gathered and analyzed. Pooled odds ratio (OR) with 95% confidence intervals (CIs) were determined. Cochran ’sQ test,I2 statistics, leave-one-out analysis, Baujat plot analysis, GOSH plot analysis, and...
Source: Clinical Rheumatology - February 2, 2023 Category: Rheumatology Source Type: research

Development and assessment of the Quality of Life Instruments for Chronic Diseases-Gout (QLICD-GO) (V2.0)
ConclusionsThe QLICD-GO (V2.0) has good reliability, validity, and responsiveness. The instrument comprehensively and objectively reflects the quality of life of patients with gout, and it can be used to assess treatment regimens developed by medical staff.Key Points• The QLICD-GO (V2.0) has been developed for patients with gout based upon the foundation of the QLICD-GM.• The QLICD-GO reflects the clinical signs and symptoms, drug-related side effects, and psychological changes specific to patients with gout.• Based on the assessment results, the QLICD-GO (V2.0) has good reliability, validity, and responsiveness.• ...
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Assessment of fore-, mid-, and rear-foot alignment and their association with knee symptoms and function in patients with knee osteoarthritis
ConclusionsKnee symptoms were significantly associated with midfoot alignment in patients with medial knee OA. This suggests that lower navicular height in patients with medial knee OA may relate with the alleviation of knee symptoms.Key Points• In patients with medial knee OA, midfoot alignment was significantly associated with knee symptoms in patients with medial knee OA; however, knee function was not associated with foot alignment.• Lower navicular height in patients with medial knee OA may relate with the alleviation of knee symptoms. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Predictors of response of rituximab in rheumatoid arthritis by weighted gene co-expression network analysis
ConclusionsBANK1 can be used as a potential biomarker to predict the response of RTX treatment in RA patients.Key Points• Identifying the hub genes BANK1 as a potential biomarker to predict the response of RTX treatment in RA patients and confirming it in validation data.• Using the WGCNA approach and LASSO analyses to identify the BANK1 in a data set consisting of two GEO data merged and assessing the correlations between BANK1 and immune infiltration by CIBERSORT algorithm. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Renal tubular acidosis and associated factors in patients with primary Sj ögren’s syndrome: a registry-based study
ConclusionsDelayed diagnosis and decreased kidney function are common in pSS patients with RTA. pSS should be considered in patients with RTA, and early recognition and treatment may be useful in slowing the deterioration of renal function in patients with pSS-RTA.Key Points•pSS patients with RTA have earlier disease onset and higher disease activity than pSS patients without RTA, but the diagnosis was frequently delayed.•Decreased kidney function are common in pSS patients with RTA.•Sj ögren’s syndrome should be considered in young female patients with unexplained RTA, whereas RTA should be screened in pSS patien...
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Analysis of the risk factors for  end‑stage renal disease and mortality in ANCA-associated vasculitis: a study from a single center of the Chinese Rheumatism Data Center
ConclusionThese findings suggest that high initial serum creatinine, a high initial BVAS score, and the need for dialysis were independent risk factors for the progression of ESRD in AAV patients.  Alveolar hemorrhage, interstitial lung disease, and low initial EGFR were independent risk factors for death.Key Points•The risk factors for ESRD in AAV determined in this study are high initial serum creatinine, a high initial BVAS score, and the need for dialysis.•The risk factors for mortality in AAV are alveolar hemorrhage, interstitial lung disease, and low initial EGFR. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

JAK-STAT signaling pathway-related gene single nucleotide polymorphisms and susceptibility to ankylosing spondylitis in eastern Chinese Han population
ConclusionThese findings indicated that JAK-STAT signaling pathway-related gene single nucleotide polymorphisms may be associated with AS susceptibility in eastern Chinese Han population.Key Points• The T allele of rs6718902 on the STAT1 gene may be a protective agent for male AS patients.• STAT1 rs1547550 GG + CG and GG genotypes were observed to be connected with a risk of male AS patients. However, STAT1 rs6718902 TT + CT and TT genotypes reduced the susceptibility risk of male AS patients compared to wild-type CC.• The JAK1 genes rs2230588, rs2780815, and rs310241 may affect disease functional status in f...
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Calcium carbonates are novel positive birefringent crystals in synovial fluid
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Correction to: Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Genital ulcers in acute Epstein-Barr virus infection mimicking Behcet ’s disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 25, 2023 Category: Rheumatology Source Type: research

Development and assessment of the Quality of Life Instruments for Chronic Diseases-Gout (QLICD-GO) (V2.0)
ConclusionsThe QLICD-GO (V2.0) has good reliability, validity, and responsiveness. The instrument comprehensively and objectively reflects the quality of life of patients with gout, and it can be used to assess treatment regimens developed by medical staff.Key Points• The QLICD-GO (V2.0) has been developed for patients with gout based upon the foundation of the QLICD-GM.• The QLICD-GO reflects the clinical signs and symptoms, drug-related side effects, and psychological changes specific to patients with gout.• Based on the assessment results, the QLICD-GO (V2.0) has good reliability, validity, and responsiveness.• ...
Source: Clinical Rheumatology - January 24, 2023 Category: Rheumatology Source Type: research

Assessment of fore-, mid-, and rear-foot alignment and their association with knee symptoms and function in patients with knee osteoarthritis
ConclusionsKnee symptoms were significantly associated with midfoot alignment in patients with medial knee OA. This suggests that lower navicular height in patients with medial knee OA may relate with the alleviation of knee symptoms.Key Points• In patients with medial knee OA, midfoot alignment was significantly associated with knee symptoms in patients with medial knee OA; however, knee function was not associated with foot alignment.• Lower navicular height in patients with medial knee OA may relate with the alleviation of knee symptoms. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 24, 2023 Category: Rheumatology Source Type: research

Predictors of response of rituximab in rheumatoid arthritis by weighted gene co-expression network analysis
ConclusionsBANK1 can be used as a potential biomarker to predict the response of RTX treatment in RA patients.Key Points• Identifying the hub genes BANK1 as a potential biomarker to predict the response of RTX treatment in RA patients and confirming it in validation data.• Using the WGCNA approach and LASSO analyses to identify the BANK1 in a data set consisting of two GEO data merged and assessing the correlations between BANK1 and immune infiltration by CIBERSORT algorithm. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 24, 2023 Category: Rheumatology Source Type: research

Renal tubular acidosis and associated factors in patients with primary Sj ögren’s syndrome: a registry-based study
ConclusionsDelayed diagnosis and decreased kidney function are common in pSS patients with RTA. pSS should be considered in patients with RTA, and early recognition and treatment may be useful in slowing the deterioration of renal function in patients with pSS-RTA.Key Points•pSS patients with RTA have earlier disease onset and higher disease activity than pSS patients without RTA, but the diagnosis was frequently delayed.•Decreased kidney function are common in pSS patients with RTA.•Sj ögren’s syndrome should be considered in young female patients with unexplained RTA, whereas RTA should be screened in pSS patien...
Source: Clinical Rheumatology - January 24, 2023 Category: Rheumatology Source Type: research