Systemic lupus erythematosus and Atopic dermatitis: A two sample Mendelian randomization study
ConclusionOur research finds that SLE is a contributing factor to the development of AD, providing valuable insights into the pathogenesis and prevention of both diseases.Key Points• Currently, there is no research that clearly indicates a causal relationship between SLE and AD. This study, for the first time, identified a positive causal relationship between SLE and AD.• The results of this study contribute to our understanding of the pathogenesis and treatment strategies for SLE and AD, providing some guidance for future clinical practice. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 13, 2024 Category: Rheumatology Source Type: research
Comparison of bone mineral density of osteoporotic and osteopenia menopausal women treated with oral bisphosphonates before stopping the treatment and 1 year after drug holiday period
ConclusionIn general, it can be said that DH can reduce FN and LS T-scores. The results indicated a significant reduction in BMD after the DH period for both the osteoporosis and osteopenia groups in the early months. Also, the effect of DH in osteoporosis patients was more compared to the osteopenia individuals, which could have implications for their treatment approach, and also its effect on bone health.Key Points• The DH can reduce FN and LS T-scores• The BMD reduced after the DH period for both the osteoporosis and osteopenia groups• After 1 year of stopping bisphosphonate treatment, the average of FN and LS BMD...
Source: Clinical Rheumatology - February 13, 2024 Category: Rheumatology Source Type: research
Systemic lupus erythematosus and Atopic dermatitis: A two sample Mendelian randomization study
ConclusionOur research finds that SLE is a contributing factor to the development of AD, providing valuable insights into the pathogenesis and prevention of both diseases.Key Points• Currently, there is no research that clearly indicates a causal relationship between SLE and AD. This study, for the first time, identified a positive causal relationship between SLE and AD.• The results of this study contribute to our understanding of the pathogenesis and treatment strategies for SLE and AD, providing some guidance for future clinical practice. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 13, 2024 Category: Rheumatology Source Type: research
Prognostic factors of fungal infection in anti-melanoma differentiation-associated gene 5 antibody-positive associated interstitial lung disease
ConclusionFungal infection is associated with an increased mortality in MDA5-ILD. The serum albumin level and corticosteroid dose should be taken into consideration when treating MDA5-ILD.Key Points• This study showed fungal infection is associated with an increased mortality in MDA5-ILD. In MDA5-ILD patients with fungal infection, the presence of decreased serum albumin level and high-dose corticosteroid therapy were identified as predictors for mortality. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research
Optimal time of starting tocilizumab in acute phase of adult-onset Still ’s disease and comparison of its efficacy with that of methotrexate: a case series and a review of the literature
We examined the significance of TCZ in terms of therapeutic efficacy, reduction in glucocorticoid usage, and safety in patients with AOSD.•We compared the therapeutic efficacy of TCZ with that of MTX, which is often used to treat glucocorticoid-resistant AOSD.•TCZ is undoubtedly a valuable treatment option for AOSD, especially when administered at relapse, suggesting both high safety and good efficacy. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research
Classifying systemic lupus erythematosus using laboratory items alone: a preliminary study
ConclusionIncorporating laboratory items alone was clinically feasible to help identify SLE. SLERPI and SLICC-2012, using laboratory items alone, were more worthwhile to promote in the clinic compared with EULAR/ACR-2019.Key Points• Laboratory items play a crucial role in the SLE classification criteria, and incorporating laboratory items alone was clinically feasible to help in the identification of SLE.• The SLERPI and SLICC-2012, using laboratory items alone, were more worthwhile to promote in the clinic compared with EULAR/ACR-2019, and the combination of the two could furtherimprove the sensitivity.• The relativ...
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research
Prognostic factors of fungal infection in anti-melanoma differentiation-associated gene 5 antibody-positive associated interstitial lung disease
ConclusionFungal infection is associated with an increased mortality in MDA5-ILD. The serum albumin level and corticosteroid dose should be taken into consideration when treating MDA5-ILD.Key Points• This study showed fungal infection is associated with an increased mortality in MDA5-ILD. In MDA5-ILD patients with fungal infection, the presence of decreased serum albumin level and high-dose corticosteroid therapy were identified as predictors for mortality. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research
Optimal time of starting tocilizumab in acute phase of adult-onset Still ’s disease and comparison of its efficacy with that of methotrexate: a case series and a review of the literature
We examined the significance of TCZ in terms of therapeutic efficacy, reduction in glucocorticoid usage, and safety in patients with AOSD.•We compared the therapeutic efficacy of TCZ with that of MTX, which is often used to treat glucocorticoid-resistant AOSD.•TCZ is undoubtedly a valuable treatment option for AOSD, especially when administered at relapse, suggesting both high safety and good efficacy. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research
Classifying systemic lupus erythematosus using laboratory items alone: a preliminary study
ConclusionIncorporating laboratory items alone was clinically feasible to help identify SLE. SLERPI and SLICC-2012, using laboratory items alone, were more worthwhile to promote in the clinic compared with EULAR/ACR-2019.Key Points• Laboratory items play a crucial role in the SLE classification criteria, and incorporating laboratory items alone was clinically feasible to help in the identification of SLE.• The SLERPI and SLICC-2012, using laboratory items alone, were more worthwhile to promote in the clinic compared with EULAR/ACR-2019, and the combination of the two could furtherimprove the sensitivity.• The relativ...
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research
Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet
AbstractAutoimmune thyroid disease (AITD) is the most prevalent autoimmune disease. It shares multiple genetic, clinical, and serologic characteristics with rheumatoid arthritis (RA). Although frequently described as a classic form of single-organ autoimmunity, the AITD disease burden in a subset of patients extends well beyond the thyroid gland. This review explores the complex interaction between the two diseases and the clinical consequences when they overlap. Beyond the well-known effects of AITD on thyroid function in RA, there is mounting evidence of the association of both conditions impacting the presentation and o...
Source: Clinical Rheumatology - February 10, 2024 Category: Rheumatology Source Type: research
Impact of subcutaneous belimumab on disease activity, patient satisfaction, and metabolic profile in long-lasting systemic lupus erythematosus
ConclusionSubcutaneous BEL was effective in improving disease activity and proteinuria in patients with chronic disease while reducing PSL. Reduction in PSL by BEL also improved lipid status, which could synergistically reduce cardiovascular risk in SLE.Key Points• Significant reduction of disease activity, proteinuria, and prednisolone was observed in patients using subcutaneous belimumab.• Patient satisfaction was higher in terms of side effects in subcutaneous belimumab compared with prednisolone.• Reduction in prednisolone by belimumab contributed to the improvement of lipid status and would reduce the cardiovasc...
Source: Clinical Rheumatology - February 9, 2024 Category: Rheumatology Source Type: research
Diagnostic value of contrast-enhanced ultrasound in the activity of idiopathic retroperitoneal fibrosis: a retrospective study
ConclusionCEUS has good diagnostic value for IRPF disease activity.Key points• Thickness and contrast-enhanced ultrasound score were significantly higher in the active group than those in inactive group (P < 0.001).• With thickness of 4 mm and contrast-enhanced ultrasound 2 score as optimal cut-off values, the sensitivity and specificity were 89.86%, 81.01% and 52.17%, 100.00%, respectively.• During follow-up, when the disease progressed, the change of CEUS score was earlier than the change of thickness. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 8, 2024 Category: Rheumatology Source Type: research
