IL-6 receptor inhibition is not associated with body weight or composition: Mendelian randomisation study
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 2, 2024 Category: Rheumatology Source Type: research
Underutilization of ambulatory blood pressure monitoring in locally and nationally representative samples of patients with childhood-onset systemic lupus erythematosus
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 22, 2024 Category: Rheumatology Source Type: research
Patient perceptions on switching from reference product adalimumab to biosimilar adalimumab-atto
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 22, 2024 Category: Rheumatology Source Type: research
Acute longus colli calcific tendinitis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 22, 2024 Category: Rheumatology Source Type: research
Underutilization of ambulatory blood pressure monitoring in locally and nationally representative samples of patients with childhood-onset systemic lupus erythematosus
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2024 Category: Rheumatology Source Type: research
Patient perceptions on switching from reference product adalimumab to biosimilar adalimumab-atto
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2024 Category: Rheumatology Source Type: research
Acute longus colli calcific tendinitis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 19, 2024 Category: Rheumatology Source Type: research
Modifying loading during gait leads to biochemical changes in serum cartilage oligomeric matrix protein concentrations in a subgroup of individuals with anterior cruciate ligament reconstruction
ConclusionThese data suggest that manipulating lower limb loading in ACLR patients who habitually exhibit an acute increase in sCOMP following walking results in improved biochemical changes linked to cartilage health.Key Points• This study assesses the mechanistic link between lower limb load modification and joint tissue biochemistry at acute and delayed timepoints.• Real-time biofeedback provides a paradigm to experimentally assess the mechanistic link between loading and serum biomarkers.• Manipulating peak loading during gait resulted in a metabolic effect of lower sCOMP concentrations in a subgroup of ACLR indi...
Source: Clinical Rheumatology - February 15, 2024 Category: Rheumatology Source Type: research
Development of a novel clinimetric tool: PAtient Reported Disease Activity Index in Rheumatoid Arthritis (PARDAI-RA) by PANLAR, for the assessment of patients living with rheumatoid arthritis
ConclusionIn this article, we present a new clinimetric tool developed based on expert consensus and on data retrieved from our search. Disease activity can be better assessed by combining various data sources, such as clinical, laboratory, and self-reported outcomes. These variables were included in our novel clinimetric tool.Key Points•The goal of treatment of RA is to achieve the best possible control of inflammation, or even remission; therefore, disease management should include systematic and regular evaluation of inflammation and health status.•Clinimetric tools evaluate a series of variables (e.g., symptoms, fu...
Source: Clinical Rheumatology - February 14, 2024 Category: Rheumatology Source Type: research
A rare twist: COVID-19 infection masquerading as IgA vasculitis in a hemophilia a patient
We report a 23-year-old man who was previously diagnosed with severe hereditary hemophilia A. He presented to our hospital with classic symptoms of IgA vasculitis, complaining of petechiae and purpura in his limbs, fatigue, body aches, poor oral intake, abdominal pain, and watery non-bloody diarrhea. He did not present with respiratory symptoms or fever typical of COVID-19 infection. Abnormal blood tests were mildly elevated C-reactive protein, elevated d-dimers, and low Factor VIII activity. Extensive immunological tests were negative. CT abdomen with contrast was unremarkable. A skin biopsy strongly indicated IgA vasculi...
Source: Clinical Rheumatology - February 14, 2024 Category: Rheumatology Source Type: research
Development of a novel clinimetric tool: PAtient Reported Disease Activity Index in Rheumatoid Arthritis (PARDAI-RA) by PANLAR, for the assessment of patients living with rheumatoid arthritis
ConclusionIn this article, we present a new clinimetric tool developed based on expert consensus and on data retrieved from our search. Disease activity can be better assessed by combining various data sources, such as clinical, laboratory, and self-reported outcomes. These variables were included in our novel clinimetric tool.Key Points•The goal of treatment of RA is to achieve the best possible control of inflammation, or even remission; therefore, disease management should include systematic and regular evaluation of inflammation and health status.•Clinimetric tools evaluate a series of variables (e.g., symptoms, fu...
Source: Clinical Rheumatology - February 14, 2024 Category: Rheumatology Source Type: research
A rare twist: COVID-19 infection masquerading as IgA vasculitis in a hemophilia a patient
We report a 23-year-old man who was previously diagnosed with severe hereditary hemophilia A. He presented to our hospital with classic symptoms of IgA vasculitis, complaining of petechiae and purpura in his limbs, fatigue, body aches, poor oral intake, abdominal pain, and watery non-bloody diarrhea. He did not present with respiratory symptoms or fever typical of COVID-19 infection. Abnormal blood tests were mildly elevated C-reactive protein, elevated d-dimers, and low Factor VIII activity. Extensive immunological tests were negative. CT abdomen with contrast was unremarkable. A skin biopsy strongly indicated IgA vasculi...
Source: Clinical Rheumatology - February 14, 2024 Category: Rheumatology Source Type: research
Comparison of bone mineral density of osteoporotic and osteopenia menopausal women treated with oral bisphosphonates before stopping the treatment and 1 year after drug holiday period
ConclusionIn general, it can be said that DH can reduce FN and LS T-scores. The results indicated a significant reduction in BMD after the DH period for both the osteoporosis and osteopenia groups in the early months. Also, the effect of DH in osteoporosis patients was more compared to the osteopenia individuals, which could have implications for their treatment approach, and also its effect on bone health.Key Points• The DH can reduce FN and LS T-scores• The BMD reduced after the DH period for both the osteoporosis and osteopenia groups• After 1 year of stopping bisphosphonate treatment, the average of FN and LS BMD...
Source: Clinical Rheumatology - February 13, 2024 Category: Rheumatology Source Type: research
