Fatty infiltration in the posterior muscles of the lower extremities as an MRI feature in antimitochondrial antibody –associated myopathy
ConclusionsSevere fatty infiltrations of the AM, SM, BF, soleus, and Gastroc M in the posterior muscles of the lower extremities are dominant MRI features in our patients with AMA-M2-positive IIM. This unique muscle MRI character may be a helpful indicator in clinical practice for patients with AMA-M2-positive IIM.Key Points•Striking involvement and prominent fatty infiltrations of five lower extremity muscles (adductor magnus, semimembranosus, biceps femoris, soleus, and the medial head of the gastrocnemius) are interesting MRI performances.•Severe fatty infiltrations in the posterior muscles of the lower extremities ...
Source: Clinical Rheumatology - January 29, 2024 Category: Rheumatology Source Type: research
Comparative analysis of optical coherence tomography angiography (OCTA) results between Beh çet’s disease patients and a healthy control group
ConclusionAccording to these findings, peripapillary and macular vessel density is affected in BD.Key Points• The study utilized OCTA to compare retinal features in Behçet’s disease (BD) patients and healthy individuals, revealing significant differences in retinal thickness and vessel density.• Ocular BD demonstrated reduced peripapillary vessel density compared to non-ocular BD.• The demonstrated association between ADMA and cIMT in patients with early SSc may suggest a role of NO/ADMA pathway in the initiation of macrovascular injury in SSc. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 29, 2024 Category: Rheumatology Source Type: research
Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study
This study unv eils significant dysregulation of lncRNAs THRIL, HIF1A-AS1, and HOTAIR in TAK patients, underscoring their potential as biomarkers and opening avenues for further research into the mechanistic roles of these lncRNAs in TAK pathogenesis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 29, 2024 Category: Rheumatology Source Type: research
The effect of COVID-19 infection on patients with rheumatic diseases in China
ConclusionsAfter the COVID-19 outbreak in China, the proportion of patients with rheumatic diseases infected with the virus was similar to that of normal individuals. But the clinical symptoms, follow-up treatment requirements, and awareness of the COVID-19 among rheumatic patients were distinct from those among non-rheumatic patients, necessitating the use of individualized diagnosis and treatment plans as well as health advice by medical professionals in clinical work.Key Points• Despite there were different comorbidities and vaccination rates, the rate of COVID-19 infection in patients with rheumatic disease was simil...
Source: Clinical Rheumatology - January 29, 2024 Category: Rheumatology Source Type: research
Validation of new immune and inflammation-related diagnostic biomarkers for RA
ConclusionWe identified immune- and inflammation-related biomarkers in RA based on bioinformatics analysis and screenedTNFSF10,IL1R1,CXCL9,ACVR1B, andIL15 as diagnostic markers for RA.Key Points•TNFSF10, IL1R1, CXCL9, ACVR1B, and IL15 may be new diagnostic biomarkers for RA.•These findings may provide a theoretical basis for early RA diagnosis. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 29, 2024 Category: Rheumatology Source Type: research
Fatty infiltration in the posterior muscles of the lower extremities as an MRI feature in antimitochondrial antibody –associated myopathy
ConclusionsSevere fatty infiltrations of the AM, SM, BF, soleus, and Gastroc M in the posterior muscles of the lower extremities are dominant MRI features in our patients with AMA-M2-positive IIM. This unique muscle MRI character may be a helpful indicator in clinical practice for patients with AMA-M2-positive IIM.Key Points•Striking involvement and prominent fatty infiltrations of five lower extremity muscles (adductor magnus, semimembranosus, biceps femoris, soleus, and the medial head of the gastrocnemius) are interesting MRI performances.•Severe fatty infiltrations in the posterior muscles of the lower extremities ...
Source: Clinical Rheumatology - January 29, 2024 Category: Rheumatology Source Type: research
Effects of a lifestyle intervention on cardiovascular risk factors in systemic lupus erythematosus patients: The study “Living well with lupus”
ConclusionThis 6-month, individualized, lifestyle intervention did not improve cardiovascular risk factors in SLE patients with a high cardiovascular risk profile.Trial Registration:clinicaltrials.gov (NCT04431167).Key Points• This study was the first to investigate the efficacy of a multifaceted lifestyle intervention in SLE patients with a high cardiovascular risk profile.• Our lifestyle intervention did not change cardiometabolic risk score or any other cardiovascular outcomes in the population.• Whether a lifestyle intervention ameliorates other health-related outcomes and wellbeing requires further assessments. ...
Source: Clinical Rheumatology - January 27, 2024 Category: Rheumatology Source Type: research
Correction to: Association between urate-lowering therapy and cardiovascular events in patients with asymptomatic hyperuricemia
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 26, 2024 Category: Rheumatology Source Type: research
Disparities in burden of disease in patients with rheumatoid arthritis across racial and ethnic groups
AbstractTo examine racial/ethnic differences in rheumatoid arthritis (RA) disease burden and change in clinical outcomes over time. We included CorEvitas Rheumatoid Arthritis Registry patients from two time periods (2013 –2015 and 2018–2020). Clinical Disease Activity Index (CDAI) (as a continuous measure and as a dichotomous measure) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) were assessed at each visit. Marginal means and their corresponding 95% confidence interval (CI) by race/ethnicity were estimated for each outcome using adjusted mixed effects linear and logistic regression models. Overall ...
Source: Clinical Rheumatology - January 25, 2024 Category: Rheumatology Source Type: research
Study on the expression changes of lncRNA in patients with systemic lupus erythematosus and its correlation with Treg cells
ConclusionsThe lncRNA expression profiles were changed in SLE patients, the differentially expressed lncRNAs were associated with abnormal number and function of Treg cells in SLE, and Treg-associated lncRNAs were associated with SLE-disease activity, which may affect the expression of STAT5, PLD1, HOPX, RUNX3 and regulate Treg cell function and participate in the pathogenesis and progression of SLE by competitively binding to miRNAs or trans-regulatory mechanism.Key points• Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and systems. lncRNAs may affect Treg cells function by regulat...
Source: Clinical Rheumatology - January 23, 2024 Category: Rheumatology Source Type: research
Phenotype of Takayasu-like vasculitis and cardiopathy in patients with Blau syndrome
ConclusionCardiovascular manifestations is not rare in BS patients. Because of its insidious onset, a systematic and comprehensive assessment of cardiovascular involvement should be performed in newly diagnosed patients with BS. Aggressive initiation of anti-TNF agents may be beneficial to improve the prognosis.Key Points•About 34.2% patients with Blau syndrome developed Takayasu-like vasculitis and/or cardiopathy.•Compared with those without angiocardiopathy, recurrent fever and application of anti-TNF agents were more frequent in BS patients with cardiovascular involvement (p < 0.001, p = 0.015)•Regular...
Source: Clinical Rheumatology - January 22, 2024 Category: Rheumatology Source Type: research
