Recurrent miscarriage and low-titer antiphospholipid antibodies
ConclusionNoteworthy distinctions in laboratory parameters were identified between the low-titer and medium-high titer groups. However, when appropriately treated, the fetal-maternal outcomes were comparable in both groups. Timely intervention by clinicians is imperative to enhance pregnancy outcomes in patients experiencing recurrent miscarriage with low levels of aPL.Key Points•This study challenges the conventional belief that only the higher antiphospholipid antibodies (aPL) titers directly correlated with worse pregnancy outcomes, which emphasized the importance of patients with low titer positive aPL-positive RM.â€...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Commentary on the respiratory infection risk in primary Sj ögren’s syndrome complicated with interstitial lung disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Regarding the association between innate immune function with disease activity in systemic lupus erythematosus patients
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Real respiratory infection risk in  primary Sjögren’s syndrome complicated with interstitial lung disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Commentary on “Digital gangrene in systemic sclerosis patients: not only due to the microvascular disease’’
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Commentary on the factors with liver fibrosis in rheumatoid arthritis patients treated with methotrexate
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Asymmetric darkened knuckles with subclinical myopathy revealed anti-Mi2b positive dermatomyositis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
ANCA-associated vasculitis presenting with isolated neurological manifestations in a patient with cocaine abuse: a case report and literature review
We present a unique case of AAV with isolated neurological manifestations presenting with multiple cranial neuropathies, leptomeningeal enhancement on imaging and histopathologic evidence of small-vessel vasculitis in the leptomeninges and brain and extensive dural fibrosis in a patient with cocaine abuse. The patient ’s progressive neurological deficits were controlled after starting immunosuppression with rituximab and prednisone. We also reviewed the literature to provide the diagnostic overview of AAV and evaluate intervention options. To our knowledge, this is the first case of AAV with isolated neurologic al manife...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Increased inferior vena cava wall thickness as a sign of extensive venous inflammation in Beh çet’s Disease
ConclusionThis study shows that venous wall inflammation is not limited to lower extremity veins and is also present in IVC walls of BD patients regardless of IVC involvement. Vascular wall inflammation is probably a widespread vascular event of all venous walls in BD.Key Points• Venous wall inflammation is not limited to lower extremity veins and is present also in IVC wall in Behçet’s disease.• Extensive venous wall inflammation in Behçet’s disease includes large venous structures despite not being clinically involved. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity
ConclusionsWhile Type 2 SLE symptoms are common in SLE, our findings suggest that patients with active nephritis experience significant Type 2 SLE symptoms that may be ameliorated as nephritis improves. We also observed that non-nephritis patients had a similar burden of Type 2 SLE symptoms as patients with active nephritis, despite having on average lower Type 1 SLE activity. Therefore, the etiology of Type 2 SLE symptoms is likely multifactorial and may be driven by inflammatory and non-inflammatory biopsychosocial factors.Key Points• Patients with active nephritis experienced significant Type 2 symptoms that may be am...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Association of congestive heart failure with mortality in individuals with rheumatoid arthritis: a cohort study
ConclusionsIn this cohort study of US adults with RA, CHF was significantly associated with an increased risk of all-cause or CVD-related death. This finding underscores the importance of CHF in the management of patients with RA and may provide future information on maintaining the health status of patients with RA.Key messages•The study findings demonstrate a significant increase in overall mortality and cardiovascular mortality among individuals with RA who develop CHF.•This knowledge can assist healthcare professionals in identifying high-risk patients who could benefit from targeted monitoring and early interventi...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Identification and verification of inflammatory biomarkers for primary Sj ögren’s syndrome
ConclusionFour inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were explored, and the underlying regulatory mechanisms and targeted drugs associated with these biomarkers were preliminarily investigated according to a series of bioinformatics methods based on the online datasets of pSS, which provided a reference for understanding the pathogenesis of pSS.Key Points•Inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were firstly identified in Sj ögren’s syndrome based on LASSO and SVM-RFE analyses.•CXCL10, EIF2AK2 and LY6E were prominently positively correlated with immature B c...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Recurrent miscarriage and low-titer antiphospholipid antibodies
ConclusionNoteworthy distinctions in laboratory parameters were identified between the low-titer and medium-high titer groups. However, when appropriately treated, the fetal-maternal outcomes were comparable in both groups. Timely intervention by clinicians is imperative to enhance pregnancy outcomes in patients experiencing recurrent miscarriage with low levels of aPL.Key Points•This study challenges the conventional belief that only the higher antiphospholipid antibodies (aPL) titers directly correlated with worse pregnancy outcomes, which emphasized the importance of patients with low titer positive aPL-positive RM.â€...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Commentary on the respiratory infection risk in primary Sj ögren’s syndrome complicated with interstitial lung disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
Regarding the association between innate immune function with disease activity in systemic lupus erythematosus patients
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
