Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria
This study aimed to assess the role of lisinopril, an ACE inhibitor, in reducing proteinuria in SCA patients. Thirty-five patients older than 15 years with known SCA (HbSS or HbS-β0) and a 24-h urinary protein level of 150 mg or more participated in this study. Urine was collected over 24 h to quantify proteinuria. The patients had a mean age of 28.5 ± 6.98 years. The median 24-h urinary protein before treatment was 0.3006 g and that after treatment was 0.150 g (P = 0.01). After a median follow-up of 38 months, 24-h urinary protein decreased in 27 (77%) patients and normalized in 18 (52%) patients. Urinary protein increa...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aamer Aleem Abdulrahman Al-Sultan Abdulkareem Alsuwaida Khalid Alsaleh Farjah Algahtani Abdulkareem Almomen Mohammad Sharif Ghazi S Alotaibi Source Type: research
Repeated human leukocyte antigens eplets, importance of typing the partner
We present a patient with subclinical AMR 1 week post transplantation.CASE REPORT: A 48-year-old, caucasian woman with end-stage kidney disease (ESKD) secondary to autosomal dominant polycystic kidney disease (ADPKD) on peritoneal dialysis was registered in deceased donor waitlist. She was a hypersensitized patient from 3 prior pregnancies with a calculated panel reactive antibody of 93,48%. She was transplanted through kidney paired exchange donation with no evidence of DSA pre transplantation. Surgery and post-op were unremarkable with excellent and immediate graft function. Per protocol DSA levels on the 5th day was DR1...
Source: Transplant Immunology - May 10, 2024 Category: Transplant Surgery Authors: Carolina Dos Reis Ferreira V ítor Martinho da Silva Fernandes Sandra Cristina Ribeiro Tafulo Ana Cerqueira Ana Cristina Braga Rocha Ana Teresa Pires Morais Nunes In ês Passos Castro Neto Ferreira Maria Joana Cunha Santos Ana Teresa Marques Teixeira Pinh Source Type: research
Clinical features and genetic analysis of 15 Chinese children with dent disease
CONCLUSION: Pediatric Dent disease is often misdiagnosed. Protein electrophoresis and genetic testing can help to provide an early and correct diagnosis.PMID:38726999 | DOI:10.1080/0886022X.2024.2349133 (Source: Renal Failure)
Source: Renal Failure - May 10, 2024 Category: Urology & Nephrology Authors: Qian Li Zhenle Yang Ruixian Zang Suwen Liu Lichun Yu Jing Wang Cong Wang Xiaoyuan Wang Shuzhen Sun Source Type: research
Association of Preterm Birth with Adverse Glomerular Disease Outcomes in Children and Adults
CONCLUSIONS: Preterm birth was a risk factor for adverse outcomes in this heterogenous cohort of children and adults with glomerular disease. Adults born preterm were more likely to have an APOL1 high-risk genotype and FSGS. In analyses adjusted for FSGS and APOL1 risk status, there was less remission and faster progression of kidney disease in those born preterm.PMID:38728081 | DOI:10.2215/CJN.0000000000000475 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 10, 2024 Category: Urology & Nephrology Authors: Jaya Isaac Jonathan Troost Yujie Wang Kelly Garrity Frederick Kaskel Rasheed Gbadegesin Kimberly Reidy Source Type: research
Membranoproliferative Glomerulonephritis Type I Associated with Intravenous Immunoglobulin Administration Arising in a Child with X-Linked Agammaglobulinemia: A Case Report and a Reappraisal
Saudi J Kidney Dis Transpl. 2023 Nov 1;34(6):660-665. doi: 10.4103/sjkdt.sjkdt_133_23. Epub 2024 May 9.ABSTRACTIn 1952, X-linked agammaglobulinemia (XLA) was discovered as a rare inherited disorder. It markedly compromises the ability of the body to combat infectious microorganisms. Membranoproliferative glomerulonephritis (MPGN) Type I is characterized by subendothelial immune complex deposits. Patients with XLA can rarely develop immune-complex-induced diseases. Here, we report a case of MPGN Type I in a 12-year-old male patient with a past and family history of XLA. The patient presented with fever, productive cough, vo...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Mahmoud Rezk Abdelwahed Hussein Mashair Babiker Sadaf Asim Mohmmed Elsamwal Source Type: research
Practice Patterns and Approach to Childhood Lupus Nephritis in Saudi Arabia
This study aimed to explore the current practices of pediatric rheumatologists and nephrologists for the diagnosis, management, and monitoring of lupus nephritis (LN) in Saudi Arabia through a survey. Among the 61 respondents, 54.1% were pediatric nephrologists and 49.9% were pediatric rheumatologists. Predominantly, the participating physicians received training either nationally (57%) or in North America (45%). Most of the respondents (77%) did not have a combined rheumatology-nephrology clinic, primarily because of space or time limitations (75%), or a lack of the other specialty (13%). In terms of the decision to reque...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Abdulaziz AlMutairi Sulaiman M Al-Mayouf Jameela Kari Emtenan Basahl Mohammed Nashawi Source Type: research
A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study
This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (&...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aditya Mahaseth Bishnu Pahari Madhav Ghimire Sushil Rayamajhi Source Type: research
Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria
This study aimed to assess the role of lisinopril, an ACE inhibitor, in reducing proteinuria in SCA patients. Thirty-five patients older than 15 years with known SCA (HbSS or HbS-β0) and a 24-h urinary protein level of 150 mg or more participated in this study. Urine was collected over 24 h to quantify proteinuria. The patients had a mean age of 28.5 ± 6.98 years. The median 24-h urinary protein before treatment was 0.3006 g and that after treatment was 0.150 g (P = 0.01). After a median follow-up of 38 months, 24-h urinary protein decreased in 27 (77%) patients and normalized in 18 (52%) patients. Urinary protein increa...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aamer Aleem Abdulrahman Al-Sultan Abdulkareem Alsuwaida Khalid Alsaleh Farjah Algahtani Abdulkareem Almomen Mohammad Sharif Ghazi S Alotaibi Source Type: research
Repeated human leukocyte antigens eplets, importance of typing the partner
We present a patient with subclinical AMR 1 week post transplantation.CASE REPORT: A 48-year-old, caucasian woman with end-stage kidney disease (ESKD) secondary to autosomal dominant polycystic kidney disease (ADPKD) on peritoneal dialysis was registered in deceased donor waitlist. She was a hypersensitized patient from 3 prior pregnancies with a calculated panel reactive antibody of 93,48%. She was transplanted through kidney paired exchange donation with no evidence of DSA pre transplantation. Surgery and post-op were unremarkable with excellent and immediate graft function. Per protocol DSA levels on the 5th day was DR1...
Source: Transplant Immunology - May 10, 2024 Category: Transplant Surgery Authors: Carolina Dos Reis Ferreira V ítor Martinho da Silva Fernandes Sandra Cristina Ribeiro Tafulo Ana Cerqueira Ana Cristina Braga Rocha Ana Teresa Pires Morais Nunes In ês Passos Castro Neto Ferreira Maria Joana Cunha Santos Ana Teresa Marques Teixeira Pinh Source Type: research
Membranoproliferative Glomerulonephritis Type I Associated with Intravenous Immunoglobulin Administration Arising in a Child with X-Linked Agammaglobulinemia: A Case Report and a Reappraisal
Saudi J Kidney Dis Transpl. 2023 Nov 1;34(6):660-665. doi: 10.4103/sjkdt.sjkdt_133_23. Epub 2024 May 9.ABSTRACTIn 1952, X-linked agammaglobulinemia (XLA) was discovered as a rare inherited disorder. It markedly compromises the ability of the body to combat infectious microorganisms. Membranoproliferative glomerulonephritis (MPGN) Type I is characterized by subendothelial immune complex deposits. Patients with XLA can rarely develop immune-complex-induced diseases. Here, we report a case of MPGN Type I in a 12-year-old male patient with a past and family history of XLA. The patient presented with fever, productive cough, vo...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Mahmoud Rezk Abdelwahed Hussein Mashair Babiker Sadaf Asim Mohmmed Elsamwal Source Type: research
Practice Patterns and Approach to Childhood Lupus Nephritis in Saudi Arabia
This study aimed to explore the current practices of pediatric rheumatologists and nephrologists for the diagnosis, management, and monitoring of lupus nephritis (LN) in Saudi Arabia through a survey. Among the 61 respondents, 54.1% were pediatric nephrologists and 49.9% were pediatric rheumatologists. Predominantly, the participating physicians received training either nationally (57%) or in North America (45%). Most of the respondents (77%) did not have a combined rheumatology-nephrology clinic, primarily because of space or time limitations (75%), or a lack of the other specialty (13%). In terms of the decision to reque...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Abdulaziz AlMutairi Sulaiman M Al-Mayouf Jameela Kari Emtenan Basahl Mohammed Nashawi Source Type: research
A Comparison of the Spot Urine Protein-Creatinine Ratio with 24-h Urinary Protein for Quantification of Proteinuria: A Hospital-based Cross-sectional Study
This study included Nepalese patients aged 2-83 years, with a mean age of 36.56 years (standard deviation: 20.78). The number of males was slightly higher than females, and the male-female ratio was 1.26:1. Hypertension was present in 44.3% of patients, diabetes was present in 20% of patients, 74.3% of patients were suffering from acute glomerulonephritis with various causes, and 12.9% of patients had chronic kidney disease. A linear relationship existed between the spot urine P-CR and the 24-h UTP, with a correlation coefficient of 0.877 (P <0.01). The correlation was suboptimal at higher levels of protein excretion (&...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aditya Mahaseth Bishnu Pahari Madhav Ghimire Sushil Rayamajhi Source Type: research
Response to Lisinopril in Patients with Sickle Cell Anemia and Proteinuria
This study aimed to assess the role of lisinopril, an ACE inhibitor, in reducing proteinuria in SCA patients. Thirty-five patients older than 15 years with known SCA (HbSS or HbS-β0) and a 24-h urinary protein level of 150 mg or more participated in this study. Urine was collected over 24 h to quantify proteinuria. The patients had a mean age of 28.5 ± 6.98 years. The median 24-h urinary protein before treatment was 0.3006 g and that after treatment was 0.150 g (P = 0.01). After a median follow-up of 38 months, 24-h urinary protein decreased in 27 (77%) patients and normalized in 18 (52%) patients. Urinary protein increa...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Aamer Aleem Abdulrahman Al-Sultan Abdulkareem Alsuwaida Khalid Alsaleh Farjah Algahtani Abdulkareem Almomen Mohammad Sharif Ghazi S Alotaibi Source Type: research
Repeated human leukocyte antigens eplets, importance of typing the partner
We present a patient with subclinical AMR 1 week post transplantation.CASE REPORT: A 48-year-old, caucasian woman with end-stage kidney disease (ESKD) secondary to autosomal dominant polycystic kidney disease (ADPKD) on peritoneal dialysis was registered in deceased donor waitlist. She was a hypersensitized patient from 3 prior pregnancies with a calculated panel reactive antibody of 93,48%. She was transplanted through kidney paired exchange donation with no evidence of DSA pre transplantation. Surgery and post-op were unremarkable with excellent and immediate graft function. Per protocol DSA levels on the 5th day was DR1...
Source: Transplant Immunology - May 10, 2024 Category: Transplant Surgery Authors: Carolina Dos Reis Ferreira V ítor Martinho da Silva Fernandes Sandra Cristina Ribeiro Tafulo Ana Cerqueira Ana Cristina Braga Rocha Ana Teresa Pires Morais Nunes In ês Passos Castro Neto Ferreira Maria Joana Cunha Santos Ana Teresa Marques Teixeira Pinh Source Type: research
Membranoproliferative Glomerulonephritis Type I Associated with Intravenous Immunoglobulin Administration Arising in a Child with X-Linked Agammaglobulinemia: A Case Report and a Reappraisal
Saudi J Kidney Dis Transpl. 2023 Nov 1;34(6):660-665. doi: 10.4103/sjkdt.sjkdt_133_23. Epub 2024 May 9.ABSTRACTIn 1952, X-linked agammaglobulinemia (XLA) was discovered as a rare inherited disorder. It markedly compromises the ability of the body to combat infectious microorganisms. Membranoproliferative glomerulonephritis (MPGN) Type I is characterized by subendothelial immune complex deposits. Patients with XLA can rarely develop immune-complex-induced diseases. Here, we report a case of MPGN Type I in a 12-year-old male patient with a past and family history of XLA. The patient presented with fever, productive cough, vo...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 10, 2024 Category: Urology & Nephrology Authors: Mahmoud Rezk Abdelwahed Hussein Mashair Babiker Sadaf Asim Mohmmed Elsamwal Source Type: research
