Immunosuppression in kidney transplant recipients with COVID-19 infection - where do we stand and where are we heading?
Authors: Daoud A, Alqassieh A, Alkhader D, Posadas Salas MA, Rao V, Fülöp T, Soliman KM Abstract The appropriate immunosuppressive regimen in kidney transplant recipients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19) infection remains unclear. The impact of direct virus injury complicated by dysregulated hyperimmune response with overwhelming release of various cytokines in COVID-19 infected subjects contributes to the complexity of management. The largest concern of the practicing clinicians at current time is how to tailor maintenance immune-modulating therapy during active ...
Source: Renal Failure - January 26, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The feasibility of one-stage flexible ureteroscopy lithotripsy in solitary kidney patients with 1-3  cm renal stones and risk factors of renal function changes.
CONCLUSION: It appears that one-stage f-URS without PS could be feasible for 10-30 mm renal stones in solitary kidney patients, and less surgical time might be beneficial to protect renal function. PMID: 33491554 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 26, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prognostic implications of predialysis patients' symptoms in peritoneal dialysis patients.
CONCLUSIONS: Our study demonstrated that nausea and anorexia were the most important predialysis symptoms, which was associated with patients' short- and long-term mortality on PD treatment, respectively. The results indicated that predialysis evaluation and management of symptoms of nausea and anorexia may be a possible way to improve patients' outcome on PD. PMID: 33478321 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 23, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review.
CONCLUSIONS: Evidence identified in this systematic review indicates a relationship between HK and LIDI with mortality in patients with renal disease receiving HD, emphasizing the need for effective monitoring and management to control potassium levels both in emergency and chronic HD settings. PMID: 33478329 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 23, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Chronic kidney disease correlates with MRI findings of cerebral small vessel disease.
Conclusions: Patients with progressive CKD have a higher prevalence and severity of CSVD, which correlates with deterioration of renal function as assessed by decreased eGFR. Thus EGFR may also be of value in the prediction of cerebral small vessel disease. PMID: 33478332 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 23, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury.
Authors: Wang RR, He M, Gui X, Kang Y Abstract BACKGROUND: Acute kidney injury (AKI) is a common complication in traumatic brain injury (TBI) patients and is associated with unfavorable outcome of these patients. We designed this study to explore the value of serum cystatin C, an indicator of renal function, on predicting AKI after suffering TBI. METHODS: Patients confirmed with TBI and hospitalized in the West China Hospital of Sichuan University between January 2015 and December 2019 were included. Patients were divided into two groups according to occurrence of AKI. Univariate and multivariate logistic regre...
Source: Renal Failure - January 23, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies.
This study found significant associations between DR and subsequent DN risk for patients with T2D. Moreover, the predictive value of DR on subsequent DN risk was relatively lower. PMID: 33478336 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 23, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Morning blood pressure surge in early autosomal dominant polycystic kidney disease and its relation with left ventricular hypertrophy.
Authors: Yildiz A, Sag S, Gul CB, Güllülü S, Can FE, Bedir Ö, Aydin MF, Oruç A, Demirel S, Akgür S, Güllülü M, Ersoy A Abstract INTRODUCTION: The activation of the sympathetic nervous system, which usually leads to a swift surge in blood pressure in the morning hours (MBPS) may be the cause of left ventricular hypertrophy (LVH) and endothelial dysfunction (ED) in early autosomal dominant polycystic kidney disease (ADPKD) patients. We studied the association between MBPS and LVH in ADPKD patients with preserved renal functions. METHODS: Patients with ADPKD with pres...
Source: Renal Failure - January 23, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Correlates of objective sleep quality in older peritoneal dialysis patients.
CONCLUSION: Older peritoneal dialysis patients had poor sleep, characterized by low sleep efficiency. Low hemoglobin and high serum phosphorus levels were predictors of poor sleep efficiency and, as such, modifiable factors for clinicians to consider when treating patients with sleep complaints. PMID: 33459122 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 20, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Pro-inflammatory cytokines as potential predictors for intradialytic hypotension.
Authors: Yu J, Chen X, Li Y, Wang Y, Cao X, Liu Z, Shen B, Zou J, Ding X Abstract BACKGROUND: Intradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, the association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate the potential role of pro-inflammatory cytokines in IDH. METHODS: MHD patients starting hemodialysis before January 2016 were enrolled in our retrospective study. Patients' characteristics, laboratory results, and intradialytic BP were ...
Source: Renal Failure - January 20, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Relationship between doses of antihypertensive drugs and left ventricular mass index changes in hemodialysis patients in a Japanese cohort.
Authors: Kitamura F, Yamaguchi M, Katsuno T, Nobata H, Iwagaitsu S, Sugiyama H, Kinashi H, Banno S, Ando M, Kubo Y, Kawade Y, Shigejiro I, Ito Y, Ishimoto T, Ito Y Abstract Left ventricular hypertrophy commonly occurs in dialysis patients and is associated with a risk of developing cardiovascular disease events and all-cause mortality. Although hypertension treatment reduces left ventricular mass index (LVMI) in hemodialysis patients, the relationships of prescription pattern, dose, and changes in the dose of antihypertensive drugs with LVMI have not been completely elucidated. Here, we hypothesized that volume red...
Source: Renal Failure - January 20, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury.
In this study, we investigated whether a 15-PGDH inhibitor can act as a candidate for blocking these two major mechanisms of CIAKI. We established a CIAKI mouse model by injecting a 10 gram of iodine per body weight (gI/kg) dose of iodixanol into each mouse tail vein. A 15-PGDH inhibitor (SW033291), PGE1, or PGE2 were administered to compare the renal functional parameters, histologic injury, vasoconstriction, and renal blood flow changes. In addition, human renal proximal tubular epithelial cells were cultured in a CM-treated medium. SW033291, PGE1, or PGE2 were added to compare any changes in cell viability and apoptosis...
Source: Renal Failure - January 20, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal involvement without infiltration of eosinophil in Kimura's disease.
Authors: Luo Y, Hu XM, Li J, Li HY, Yi XM, Peng QF PMID: 33441037 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 16, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors and outcomes of cardiovascular disease readmission within the first year after dialysis in peritoneal dialysis patients.
Authors: Li J, Huang N, Zhong Z, Joe P, Wang D, Ai Z, Wu L, Jiang L, Huang F Abstract BACKGROUND: In the first year of dialysis, patients are vulnerable to cardiovascular disease (CVD) hospitalization, but knowledge regarding the risk factors and long-term outcomes of cardiovascular readmission within the first year after dialysis in incident continuous ambulatory peritoneal dialysis (CAPD) patients is limited. METHODS: This retrospective cohort study was conducted in incident CAPD patients. The demographic characteristics, laboratory parameters, and CVD readmission were collected and analyzed. The primary outc...
Source: Renal Failure - January 16, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The clinical and immunological features of the post-extracorporeal shock wave lithotripsy anti-glomerular basement membrane disease.
CONCLUSION: Although further exploration is required to prove the causal relationship in this rare condition, our study reminds physicians that patients developing acute renal insufficiency after ESWL should lead to the suspicion of anti-GBM disease and in-time diagnosis and treatment. PMID: 33435789 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 15, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF- κB signaling pathway to improve diabetic nephropathy.
Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy. Ren Fail. 2021 Dec;43(1):128-140 Authors: Liu Y, Liu W, Zhang Z, Hu Y, Zhang X, Sun Y, Lei Q, Sun D, Liu T, Fan Y, Li H, Ding W, Fang J Abstract Diabetic nephropathy (DN) is a common complication of diabetes. Yishen capsule, composed of Chinese herbs, improves the clinical outcome in DN patients. However, its therapeutic potential and underlying mechanisms require further elucidation. Hence, our study aimed to investigate the underlying mechanisms and therapeutic potential ...
Source: Renal Failure - January 13, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute effects of dietary phosphorus intake on markers of mineral metabolism in hemodialysis patients: post hoc analysis of a randomized crossover trial.
Authors: Tsai WC, Wu HY, Chiu YL, Yang JY, Pai MF, Wu YR, Lin WY, Hung KY, Chien KL, Hsu SP, Peng YS Abstract BACKGROUND: Long-term dietary phosphorus excess influences disturbances in mineral metabolism, but it is unclear how rapidly the mineral metabolism responds to short-term dietary change in dialysis populations. METHODS: This was a post hoc analysis of a randomized crossover trial that evaluated the short-term effects of low-phosphorus diets on mineral parameters in hemodialysis patients. Within a 9-day period, we obtained a total of 4 repeated measurements for each participant regarding dietary intake p...
Source: Renal Failure - January 13, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Any heart failure treatments associated with worsening renal function in patients admitted due to acute heart failure?
CONCLUSIONS: After examining several heart failure treatments and baseline factors, we found that beta blocker treatment results improvement in kidney function. PMID: 33406953 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 9, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review.
CONCLUSIONS: Specific alterations of gut microbial parameters in patients with CKD were identified. However, a full picture of the gut microbiota could not be drawn from the data due to the differences in methodology, and qualitative and incomplete reporting of different studies. PMID: 33406960 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 9, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

COQ2 mutation associated isolated nephropathy in two siblings from a Chinese pedigree.
CONCLUSION: The 2 cases harboring COQ2compound heterozygous mutations presented with isolated SRNS, with a renal pathology of FSGS and a large quantity of mitochondria with normal contour accumulated within the podocytes. CoQ10 was efficacy in eliminating proteinuria. PMID: 33397173 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 6, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The impact of location and patency of the arteriovenous fistula on quality of life of kidney transplant recipients.
CONCLUSIONS: The influence of persistent PAVF in KTRs seems to be unfavorable, especially when coexisting with CAD or HF. Abbreviations: AVF arteriovenous fistula; BMI body mass index; CAD coronary artery disease; D-AVF distally-located arteriovenous fistula; EC exercise capacity; HD hemodialysis; HF heart failure; KTx kidney transplantation; KTR kidney transplant recipient; LVD-36 Left Ventricle Disfunction - 36; LVEF left ventricle ejection fraction; LVH left ventricle hypertrophy; NYHA New York Heart Association; P-AVF proximally located arteriovenous fistula; PD peritoneal dialysis; PRO patient-reported outcomes; QOL q...
Source: Renal Failure - January 6, 2021 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of clinical factors on trajectory of functional performance in patients undergoing hemodialysis.
This study aimed to investigate the association between clinical factors and temporary changes in functional performance in patients undergoing hemodialysis. METHODS: This was a retrospective, longitudinal observational study conducted from 2015 to 2017. Eight-two patients undergoing hemodialysis in the outpatient clinic were enrolled. Functional performance was measured using the Karnofsky Performance Status (KPS) scale. Collected data for analysis included demographics, laboratory parameters, and KPS scale scores. All participants were grouped into a high KPS cluster and a low KPS cluster based on dynamic changes in ...
Source: Renal Failure - December 24, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Three cases of retained cuff related infection after manual pull removal of peritoneal dialysis catheter.
Authors: Zhang S, Zhang X, Li H, Wei Z, Cao J PMID: 33349099 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 24, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical profile of a Polish cohort of children and young adults with cystinuria.
CONCLUSIONS: The clinical course of cystinuria is similar among patients, regardless of the type of genetic mutation. Most patients require surgery before diagnosis or soon after it. Patients require combined urological and pharmacological treatment for prevention of stone recurrence and renal function preservation. PMID: 33349102 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 24, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease - a fifteen year single center experience.
CONCLUSIONS: Anti-GBM is a rare disease with poor prognosis and varied presentations. Patients with pulmonary-renal syndrome showed severe disease whereas double positive had more of chronic changes. The predictors of poor prognosis include advanced age, oliguria, serum anti-GBM levels, serum creatinine levels, degree of glomerulosclerosis and IFTA. Atypical anti-GBM cases should be kept in mind while evaluating renal biopsies. PMID: 33334228 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 20, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of hemodialysis treatment on saliva flow rate and saliva composition during in-center maintenance dialysis: a cross-sectional study.
Authors: Yu IC, Liu CY, Fang JT Abstract AIM: To analyze changes in saliva flow rate and clinical measures from unstimulated whole saliva (UWS) among patients undergoing hemodialysis for end-stage kidney disease (ESKD). BACKGROUND: Chronic hemodialysis causes changes in blood chemistry as well as dry mouth, due to removal of excess fluids. UWS is used to examine saliva flow rate as an indicator of mouth dryness. Whether UWS can be used to measure changes in clinical variables following hemodialysis has not been explored. DESIGN: A cross-sectional quantitative study. METHODS: Patients with ESKD were recr...
Source: Renal Failure - December 18, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Sustained remission of rapidly progressive post-transplant immunoglobulin A nephropathy by treatment with tonsillectomy following steroid pulse therapy: a case report.
Authors: Yamashiro A, Yamada M, Kihara Y, Konno O, Iwamoto H, Oda T PMID: 33327834 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 18, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High ultrafiltration rate induced intradialytic hypotension is a predictor for cardiac remodeling: a 5-year cohort study.
Authors: Yu J, Chen X, Li Y, Wang Y, Liu Z, Shen B, Teng J, Zou J, Ding X Abstract BACKGROUND: Intradialytic-hypotension (IDH) is a common complication of hemodialysis. High ultrafiltration rate (UFR) might lead to IDH. However, the relationships between UFR, IDH, and cardiac remodeling among hemodialysis patients in the long-term have not been deeply explored. METHODS: This retrospective cohort study collected clinical and echocardiographic data. Patients were enrolled from 1 January 2014 to 31 March 2014 and were followed-up for 5-year. Those who suffered from more than four hypotensive events during three mo...
Source: Renal Failure - December 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Elevated atherogenic index and higher triglyceride increase risk of kidney function decline: a 7-year cohort study in Chinese adults.
This study explored whether lipid disorders or an elevated atherogenic index of plasma (AIP, a risk factor for cardiovascular diseases) could predict major kidney function decline. METHODS: We conducted a retrospective 7-year cohort study of 3712 Chinese adults followed up between 2010 and 2017. Major kidney function decline was defined as a ≥ 30% reduction in the estimated glomerular filtration rate (eGFR) from baseline. Multivariable logistic regression models were used to evaluate the relationship between lipid profiles and major kidney function decline. Smoking habits, waist circumference, and phys...
Source: Renal Failure - December 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diagnostic value of TWEAK for predicting active lupus nephritis in patients with systemic lupus erythematosus: a systematic review and meta-analysis.
CONCLUSIONS: Our results suggest that TWEAK might be a potential biomarker for patients with active LN. Future cross-sectional and longitudinal studies are needed to confirm its diagnostic value, as well as to establish more definite cutoff for active LN. PMID: 33307926 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical features and outcome of maintenance hemodialysis patients with COVID-19 from a tertiary nephrology care center in Romania.
CONCLUSIONS: In conclusion, we observed a high mortality rate among maintenance hemodialysis patients hospitalized for COVID-19. Anemia, lower serum albumin and lower basal oxygen saturation at admission were factors associated with poor prognosis. PMID: 33307933 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Physical activity and renal function in the Italian kidney transplant population.
CONCLUSIONS: Penchant for PA is more frequent among male and younger KTRs. Moreover, in our group of Italian KTRs, active patients revealed higher eGFR values and preserved kidney function over time, up to 10-years of follow-up. PMID: 33256487 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 3, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review.
Authors: Zhou S, Xu J, Xue C, Yang B, Mao Z, Ong ACM Abstract OBJECTIVES: A meta-analysis and systematic review was conducted on kidney-related outcomes of three recent pandemics: SARS, MERS, and COVID-19, which were associated with potentially fatal acute respiratory distress syndrome (ARDS). METHODS: A search of all published studies until 16 June 2020 was performed. The incidence/prevalence and mortality risk of acute and chronic renal events were evaluated, virus prevalence, and mortality in preexisting hemodialysis patients was investigated. RESULTS: A total of 58 eligible studies involving 13452 hospi...
Source: Renal Failure - December 3, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

'I hear and I forget. I see and I remember. I do and I understand.'- incorporating high-fidelity medical simulation into the undergraduate nephrology course.
CONCLUSION: Medical simulation is a valuable constituent of the nephrology course. Putting greater emphasis on practical aspects from the beginning of training may enable students to benefit more from simulation modules. PMID: 33243066 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 28, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The research status and prospect of Periostin in chronic kidney disease.
Authors: Jia YY, Yu Y, Li HJ Abstract The continuous accumulation of extracellular matrix will eventually lead to glomerular sclerosis, interstitial fibrosis, tubular atrophy and vascular sclerosis, which are involved in the progression of chronic kidney disease (CKD). If these processes can be discovered early and effective interventions given in time, the progression of kidney disease may be delayed. Therefore, exploring new biomarkers and therapeutic targets that can identify CKD at an early stage is urgently needed. In recent years, studies have shown that urine periostin may be used as a marker of early renal ...
Source: Renal Failure - November 27, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Tamibarotene inhibit the accumulation of fibrocyte and alleviate renal fibrosis by IL-17A.
Authors: Li L, Luo R, Yang Y, Cheng Y, Ge S, Xu G Abstract Renal fibrosis is a common pathological process in the progression of chronic kidney disease. Accumulating evidence suggests that interleukin-17A (IL-17A) and fibrocytes play crucial roles in the pathogenesis of fibrosis. However, the role of IL-17A in the regulation of renal fibrocytes in renal fibrosis has rarely been reported. Here, we report that the plasma IL-17A level is increased in immunoglobulin A nephropathy (IgAN) patients and is correlated with clinical parameters. Using a mouse model of unilateral ureteral obstruction (UUO), we found that both ...
Source: Renal Failure - November 21, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal allograft surveillance with allospecific T-cytotoxic memory cells.
CONCLUSION: Allospecific T-cytotoxic memory cells distinguished primary RTR with quiescent allografts from those with dysfunction. With serial surveillance measures, this test system may facilitate decisions to manage immunosuppression in RTR. PMID: 33203287 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 20, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

What is the relationship between sclerostin and cardiovascular events in hemodialysis patients?
Authors: Zhao Y, Wang W, Dong Z PMID: 33198549 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 18, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Value of the high-sensitivity troponin T assay for diagnosis of acute myocardial infarction in patients with and without renal insufficiency.
Authors: Hsu CK, Wu IW, Chen YT, Peng CH, Tseng YJ, Chen YC, Hung MJ, Kao YC Abstract BACKGROUND: Cardiac troponins are important markers for diagnosis of acute myocardial infarction (AMI) in general population; however, chronically-elevated troponins levels are often seen in patients with renal insufficiency, which reduce their diagnostic accuracy. The aim of our study was to access the diagnostic values of initial high-sensitive cardiac troponin T (hs-cTnT) and relative change of hs-cTnT for AMI in patients with and without renal insufficiency. METHODS: Cardiac care unit patients with elevated hs-cTnT levels ...
Source: Renal Failure - November 17, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Indoxyl sulfate and high-density lipoprotein cholesterol in early stages of chronic kidney disease.
This study was designed to explore the potential relationship between IS and HDL-c levels in early stages of CKD population. METHODS: Patients of CKD stage 1-3 were enrolled in this cross-sectional study. Correlations between HDL-c and IS levels were investigated among various clinicopathological variables through independent samples t test and multivariate logistic regression. RESULTS: A total of 205 CKD patients (96 men) aged 43.27 ± 13.80 years old were included in this research. There were 96 patients (46 men) in CKD stage1 and 109 (50 men) in CKD stage 2 or stage 3. IS levels were s...
Source: Renal Failure - November 17, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical features, risk factors, and clinical burden of acute kidney injury in older adults.
Conclusion: AKI occurs in>25% of older adults in the geriatric ward. In addition to traditional risk factors, dementia and tumors were risk factors for AKI in older adults. AKI is closely related to a poor prognosis. PMID: 33191852 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 17, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Event- and time-based prospective memory in hemodialysis patients.
Authors: Wang B, Li M, Tang F, Wang Y, Han Y, Lu W, Zhang L, Zhang L, Ni W, Zhang L, Zhang L Abstract OBJECTIVE: The present study investigated whether hemodialysis (HD) patients exhibit future memory impairment (PM; the capability of remembering to perform expected future actions) and exploring relevant factors of PM task performance. METHODS: Sixty HD patients and 60 healthy controls matched by age are enrolled in the Mini-Mental State Examination (MMSE), Finger Span Test (DST), Oral Fluency Test (VFT), Ray Auditory Oral Learning Test (RAVLT), Received Stroop Color Word Interference Test (SCWT), and event-bas...
Source: Renal Failure - November 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diabetes is a risk factor for high-dose methotrexate-associated AKI in lymphoma patients.
CONCLUSIONS: Patients with T2D have a higher sensitivity to AKI when administrated with HDMTX. This conclusion addresses safety concerns for making chemotherapy regimen for this population. PMID: 33164656 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 11, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Incidence of and risk factors for post-parathyroidectomy hungry bone syndrome in patients with secondary hyperparathyroidism.
This study aims to determine the incidence and risk factors of post-parathyroidectomy HBS in dialysis patients with secondary hyperparathyroidism (SHPT). METHODS: A retrospective cohort study was conducted, and medical records of patients with SHPT requiring parathyroidectomy between January 2014 and January 2020 were reviewed. HBS was defined as the requirement of intravenous calcium administration due to hypocalcemia-related symptoms and/or reductions in serum calcium concentration (
Source: Renal Failure - November 6, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The gut microbiome in differential diagnosis of diabetic kidney disease and membranous nephropathy.
CONCLUSION: The composition of the gut microbiome appears to differ considerably between patients with DKD and those with MN. Thus, microbiome-based markers could be used as an alternative tool to distinguish DKD and MN. PMID: 33121301 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A visual risk assessment tool for acute kidney injury after intracranial aneurysm clipping surgery.
CONCLUSION: The novel nomogram model can serve as a promising predictive tool to improve the identification of AKI among those who underwent intracranial aneurysm clipping surgery. PMID: 33115300 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 31, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The incidence of cytomegalovirus infection after deceased-donor kidney transplantation from hepatitis-C antibody positive donors to hepatitis-C antibody negative recipients.
CONCLUSION: The incidence of CMV infection was similar in recipients who received HCVAb D + and HCVAb D - KT. Further studies are needed to assess this association in KT from HCV nucleic acid positive donors. PMID: 33100098 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 28, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Neutrophil-to-lymphocyte ratio in relation to the risk of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis.
CONCLUSION: NLR is a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease. PMID: 33081569 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 22, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hepatitis C virus and carpal tunnel syndrome in hemodialysis patients: a single center cross-sectional study.
This study aimed at evaluating the association of HCV infection with CTS. METHODS: Using a cross-sectional design, anthropometric and laboratory data were collected. Serum β2-microglobulin, HCV antibody and HCV-RNA were measured. CTS was diagnosed according to clinical manifestation, electrophysiological test or ultrasonography. The related factors for CTS were analyzed by multivariate logistic regression. RESULTS: This study included 113 participants, of whom 33 (29.2%) patients were positive for HCV antibody and 18 (15.9%) were positive for HCV antibody and HCV-RNA. Thirty-two (28.3%) patients were diagnosed...
Source: Renal Failure - October 21, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of hyperuricemia and serum uric acid lowering therapy with mortality in hemodialysis patients.
DISCUSSION: In contrast to the general population, hyperuricemia is not associated with increased mortality in patients undergoing hemodialysis. Moreover, xanthine oxidase inhibition was not associated with a survival benefit in this analysis. These data do not support the use of SUA lowering medication in hemodialysis patients with asymptomatic hyperuricemia. PMID: 33076736 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 21, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research