Evaluation of body composition monitoring for assessment of nutritional status in hemodialysis patients.
CONCLUSIONS: LTI is a predictor of mortality, and its predictive power was not affected when FTI, SGA, and hydration status were included in the multivariate analysis. However, SGA may not be adequate to identify patients at a risk of death among Chinese hemodialysis patients. PMID: 31057002 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal injury in obese children.
Authors: Kawada T PMID: 31057014 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy.
This study aimed to investigate the unique prognostic, clinical, and renal histopathological characteristics of patients with idiopathic membranous nephropathy (IMN) with different levels of proteinuria. METHODS: This retrospective observational study included 190 IMN patients with low levels of proteinuria (low group), 193 IMN patients with medium levels of proteinuria (medium group), and 123 IMN patients with high levels of proteinuria (high group) treated between September 2006 and November 2015. Prognostic and baseline clinical and histopathological data were compared among the three groups. Poor prognostic events ...
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy.
Authors: Liu Y, Zheng J, Jia J, Li H, Hu S, Lin Y, Yan T Abstract BACKGROUND: Recent genomewide association study suggested that the top single-nucleotide polymorphism, rs978056, in HECW1 gene (which encodes HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) associated with the levels of galactose-deficient IgA1 (Gd-IgA1) in IgA nephropathy (IgAN). However, HECW1 expression in IgAN has not yet been examined. METHODS: In the following study, we have enrolled 40 patients with IgAN and 40 healthy controls. The expression level of HECW1, as well as plasma levels of Gd-IgA1 and IgA1, were determined de...
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Cadmium regulates von Willebrand factor and occludin expression in glomerular endothelial cells of mice in a TNF- α-dependent manner.
CONCLUSIONS: These results suggest that TNF-α acts to balance homeostasis of glomerular endothelium after Cd treatments. PMID: 31057027 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy.
CONCLUSION: We found that rapamycin has protective effects in the IgA nephropathy rat model in a dose-dependent manner. In addition, the result of western blot assay suggested that rapamycin may display its therapeutic effects through interfering the AKT-mTOR-p70S6K signaling pathway. PMID: 31057050 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of iodine contrast-induced acute kidney injury via different injection routes using BOLD-MRI.
CONCLUSIONS: The renal injury induced by 1.0 g iodine/kg iodixanol through renal artery injection was more significant than that caused by the same dose of femoral artery and auricular vein injection, while similar to that caused by 2.0 g iodine/kg femoral artery injection. PMID: 31057054 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The incidence of acute kidney injury following cardiac arrest and cardiopulmonary resuscitation in a rat model.
CONCLUSION: The incidence of AKI in rats was high after suffering from CA and CPR, but renal function improved with the prolongation of ROSC time, indicating the ability of the kidney to self-repair. PMID: 31014141 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The association between chronic musculoskeletal pain and clinical outcome in chronic kidney disease patients: a prospective cohort study.
CONCLUSION: The CKD patients with chronic MS pain was independently and significantly associated with all-cause mortality, but not independently and significantly associated with CKD progression and composite endpoints. The inflammatory marker-hs-CRP was similar between CKD patients with and without chronic MS pain. PMID: 31014149 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.
CONCLUSION: Renal function was a strong determinant of NLR in cardiovascular outpatients. NLR elevation due to renal impairment is caused by distortion of the hematopoietic process in bone marrow. IS plays a significant role in these processes. PMID: 31014150 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis.
CONCLUSIONS: The pooled prevalence of CAC is highly prevalent. CAC is independently associated with all-cause and cardiovascular mortality risk as well as cardiovascular events among CKD patients. In view of the high heterogeneity, larger clinical trials are still needed. PMID: 31014155 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Autophagy activity and expression pattern of autophagy-related markers in the podocytes of patients with lupus nephritis: association with pathological classification.
Authors: Jin J, Tu Q, Gong J, Zhao L, Liang S, He Q Abstract OBJECTIVE: To identify the significance of autophagy in lupus nephritis (LN). METHODS: The number of autophagosomes in podocytes was counted and the expression of multiple molecular markers associated with autophagy was evaluated in LN specimens: in renal biopsy specimens from 90 patients with LN and 15 healthy controls, autophagosomes in podocytes were counted using transmission electron microscopy and the expression levels of four autophage related proteins including Beclin-1, microtubule-associated protein light chain 3 (LC3), autophagy-related gen...
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effectiveness of cinacalcet: a randomized, open label study in chronic hemodialysis patients with severe secondary hyperparathyroidism.
CONCLUSIONS: The effectiveness of cinacalcet were still obviously demonstrated even in chronic HD patients with severe SHPT. In addition, the improvements of bone markers and FGF-23, and stabilization of vascular calcification were observed. Therefore, cinacalcet can provide salutary effects on CKD-MBD in severe SHPT and might be an initially effective PTH-lowering therapy prior to surgical parathyroidectomy as well as an alternative treatment in the patients unsuitable for surgery. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov: NCT02056730. Date of registration: February 4, 2014. PMID: 31014177 [PubMed - in proc...
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of Staphylococcus nasal colonization and HIV in end-stage renal failure patients undergoing peritoneal dialysis.
This study evaluated the effects of HIV infection on nasal carriage of Staphylococcus aureus, staphylococcal peritonitis, and catheter infection rates in patients with end-stage renal failure managed with continuous ambulatory peritoneal dialysis (CAPD). METHODS: Sixty HIV-positive and 59 HIV-negative CAPD patients were enrolled and followed up for up to 18 months. S. aureus nasal carriage (detected by nasal swab culture), Staphylococcal peritonitis (diagnosed by clinical presentation, and CAPD effluent Staphylococcal culture and white blood cell count ≥100 cells/µL), and catheter infections (including ...
Source: Renal Failure - April 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Authors: Sukkummee W, Jittisak P, Wonganan P, Wittayalertpanya S, Chariyavilaskul P, Leelahavanichkul A Abstract Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in functions of drug-metabolizing enzymes in the liver and functions of intestinal drug transporters. We compared the defect on mouse CYP3A11 (human CYP3A4 representative) in liver and intestine along with several intestinal drug transporters (MDR1a, MRP2, and...
Source: Renal Failure - April 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of anti-peritoneal fibrotic effects between an mTORC1-specific blocker and a PI3K/mTOR dual-blocker.
CONCLUSION: RAPA did not up-regulate p-Akt in a negative feedback fashion. Both drugs effectively inhibited peritoneal fibrosis. PMID: 30982374 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 16, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Glomerular expression of matrix metalloproteinases in systemic lupus erythematosus in association with activity index and renal function.
Authors: Adamidis KN, Kopaka ME, Petraki C, Charitaki E, Apostolou T, Christodoulidou C, Nikolopoulou N, Giatromanolaki A, Vargemesis V, Passadakis P Abstract PURPOSE: The aim of this study was to examine the expression of matrix metalloproteinases (MMPs) MMP-1, MMP-2, MMP-3, MMP-9, and their specific tissue inhibitor TIMP-1 in kidney biopsies of patients with lupus nephritis (LN) and to investigate the relationship between MMPs, activity index, and renal function at the time of kidney biopsy. METHODS: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in...
Source: Renal Failure - April 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification.
Authors: Wang C, Tang Y, Wang Y, Li G, Wang L, Li Y Abstract Vascular calcification (VC) is a pathological process characterized by abnormal deposition of calcium phosphate, hydroxyapatite and other mineral substances in the vascular wall. Hyperphosphorus is an important risk factor associated with VC in the general population and patients with chronic kidney disease (CKD). However, there is still a lack of early biomarkers for hyperphosphorus induced VC. We established a calcific rat aorta vascular smooth muscle cells (RASMCs) model by stimulating with β-glycerophosphate. Then we performed label-free quantita...
Source: Renal Failure - April 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China.
Authors: Yang Y, Zhou W, Wang Y, Zhou R Abstract OBJECTIVE: To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference. METHODS: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR)
Source: Renal Failure - April 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renoprotective effect of oral rehydration solution III in exertional heatstroke rats.
CONCLUSION: ORS III could alleviate the kidney injury in EHS rats. PMID: 30942115 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease.
CONCLUSION: The present study demonstrated that a high NLR was associated with poor renal outcomes, suggesting that NLR may be a useful marker for prognostic prediction in patients with CKD. PMID: 30942116 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of glycemic status on the performance of cystatin C for acute kidney injury detection in the critically ill.
CONCLUSION: Glycemic status has no significant impact on the accuracy of sCysC for AKI detection in critically ill adults and a higher optimal cutoff value of sCysC for AKI detection should be considered in diabetic patients. PMID: 30942122 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Incidence, risk factors, and clinical outcomes of acute kidney injury associated with acute pyelonephritis in patients attending a tertiary care referral center.
Authors: Jeon DH, Jang HN, Cho HS, Lee TW, Bae E, Chang SH, Park DJ Abstract Acute kidney injury (AKI) associated with acute pyelonephritis (APN) rarely has been reported. The aim of this study was to evaluate the incidence and risk factors of AKI associated with APN. We retrospectively reviewed the medical records of 403 patients over 18-year old age hospitalized for APN management from October 2009 to September 2014 in tertiary care referral center. Demographic data, clinical symptoms and signs, and laboratory findings were gathered from the medical records and analyzed. The mean age of patients was 57 years...
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of bone marrow mesenchymal stem cells modified with klotho on renal ischemia-reperfusion injury.
CONCLUSIONS: BMSCs transfected with Klotho gene can further ameliorate RIRI. The possible mechanism may be attributed to the upregulation of SOD in NRK-52E caused by Klotho-FoxO1 axis. PMID: 30942135 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Refractory secondary hyperparathyroidism in waiting list for parathyroidectomy: who we should operate first in a quaternary hospital in Brazil regarding survival.
CONCLUSIONS: Patients with severe SHPT are at increased risk of death while waiting for PTX. Clinical events like fracture were not used to prioritize patients beyond consecutive order. Therefore, optimizing priority criteria for PTX may result in improved survival in this population. PMID: 30942649 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model.
CONCLUSIONS: Omega-3 FA supplementation decreased erythrocyte membrane oleic acid content by modulating SCD-1 and Elovl-6 expression in the kidney and liver of CsA-induced rats. PMID: 30943799 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Intermedin protects HUVECs from ischemia reperfusion injury via Wnt/ β-catenin signaling pathway.
Intermedin protects HUVECs from ischemia reperfusion injury via Wnt/β-catenin signaling pathway. Ren Fail. 2019 Nov;41(1):159-166 Authors: Wang Y, Wu Z, Tian J, Mi Y, Ren X, Kang J, Zhang W, Zhou X, Wang G, Li R Abstract Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP) superfamily and a pro-angiogenic factor. In the present study, we identified activation of the Wnt/β-catenin signaling pathway by IMD. Adding CoCl2 HUVECs was used to establish an in vitro model. The migration of HUVECs was measured by wound healing assays and transwell migration assays. Capillary form...
Source: Renal Failure - April 2, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prophylactic laparoscopic omentopexy: a new technique for peritoneal dialysis catheter placement.
CONCLUSION: Laparoscopic PD catheter insertion using omentopexy can decrease catheter obstruction and migration. PMID: 30909767 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The value of combined hemodynamic, respiratory and intra-abdominal pressure monitoring in predicting acute kidney injury after major intraabdominal surgeries.
Authors: Kopitkó C, Medve L, Gondos T Abstract BACKGROUND: The incidence of postoperative acute kidney injury (AKI) is predominantly determined by renal hemodynamics. Beside arterial blood pressure, the role of factors causing a deterioration of venous congestion (intraabdominal pressure, central venous pressure, mechanical ventilation) has emerged. The value of combined hemodynamic, respiratory and intra-abdominal pressure (IAP) monitoring in predicting postoperative acute kidney injury has received only limited exploration to date. METHODS: Data were collected for adult patients admitted after major ab...
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Robot-assisted radical nephrectomy for primary renal mesenchymal chondrosarcoma: case report and literature review.
Authors: Deng W, Zhou J, Liu X, Chen L, Guo G, Fu B Abstract As an extremely rare malignant neoplasm, only 12 mesenchymal chondrosarcoma (MC) arising in kidney have been reported to date. Herein, we reported a case of primary renal MC resected with robot assistance, which has not been reported before. According to the cases reported in English literature, we analyzed the characteristics of this rare malignancy and systematically review its treatment. PMID: 30909775 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Phosphate supplementation for hypophosphatemia during continuous renal replacement therapy in adults.
CONCLUSION: Phosphate supplementation effectively corrected CRRT-induced hypophosphatemia in critically ill patients with an acute kidney injury. The use of 2 mmol/L phosphate is appropriate in patients with CRRT-induced hypophosphatemia, but a different concentration could be required to prevent hypophosphatemia at the start of CRRT. PMID: 30909778 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Carotid intima-media thickness is an independent predictor of all-cause mortality and cardiovascular morbidity in patients with diabetes mellitus type 2 and chronic kidney disease.
Authors: Roumeliotis A, Roumeliotis S, Panagoutsos S, Theodoridis M, Argyriou C, Tavridou A, Georgiadis GS Abstract BACKGROUND: Intima-Media-Thickness of the carotid artery wall (cIMT) is a strong predictor of cardiovascular (CV) disease. The aim of this study was to investigate the significance of cIMT as an independent prognostic factor for CV morbidity and mortality in patients with chronic kidney disease (CKD) and diabetes mellitus type 2 (DM2). METHODS: The study included 142 diabetic patients in different stages of CKD. Patients were categorized into two groups according to low (≤0.86 mm) or hig...
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Successful transplantation of kidneys from deceased donors with terminal acute kidney injury.
Authors: Domagala P, Gorski L, Wszola M, Kieszek R, Diuwe P, Goralski P, Drozdowski J, Ostaszewska A, Gozdowska J, Ciszek M, Trzebicki J, Durlik M, Paczek L, Chmura A, Kwiatkowski A Abstract BACKGROUND: There are many doubts with regards to accepting deceased kidneys with acute kidney injury (AKI) for transplantation. PURPOSE: The aim of this study was to present the 5-years outcome of kidney transplantation cases where deceased donors developed AKI before organ procurement. METHODS: Two hundred twenty-six deceased renal transplants were analyzed. Data regarding donors and recipients were collected. Termina...
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility.
Authors: Aihara S, Yamada S, Oka H, Kamimura T, Nakano T, Tsuruya K, Harada A Abstract BACKGROUND: Eldecalcitol (ELD) is an active vitamin D3 analog that is widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction of ELD is hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia. MATERIALS AND METHODS: We retrospectively reviewed the medical records at our hospital for cases of hypercalcemia-induced AKI between April 2013 and February 2018. Among them, we focused on patients who developed AKI secondary to ELD-in...
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Single dose oral ranolazine pharmacokinetics in patients receiving maintenance hemodialysis.
CONCLUSIONS: Data on ranolazine dosing in patients receiving maintenance hemodialysis is almost non-existent. Given the extent of pharmacokinetic variability observed with the 500 mg and 1000 mg oral doses of ranolazine, neither can be recommended as a starting dose in patients receiving maintenance hemodialysis. Guided by the information gained form this study about the extent of hemodialytic drug clearance, further multi-dose clinical trials of ranolazine are needed to optimize therapeutic outcomes in this patient population. PMID: 30909832 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Kidney injury molecule-1 expression predicts structural damage and outcome in histological acute tubular injury.
CONCLUSION: The uKIM-1 level corresponds with the severity of renal histological damage and can be a potential reliable predictor of adverse renal outcomes in ATI patients. Moreover, combining uKIM-1 and sKIM-1 can increase the sensitivity and specificity of the diagnosis of severe ATI. PMID: 30909833 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Kimura's disease with membranoproliferative glomerulonephritis: a case report with literature review.
Authors: Su S, Chen X, Li J, Yu J, Zhang L Abstract BACKGROUND: Kimura's disease is a rare disease and its etiology is still unclear. Here we reported a case with lymphadenopathy complicated with secondary membranoproliferative glomerulonephritis. CASE PRESENTATION: A 46-year-old Chinese man presented with bilateral tumor-like nodules over his neck during the past 6 months and developed edema for 15 days. His blood pressure was 145/90 mmHg, multiple 1 × 1 cm masses were found over bilateral post-auricular and submandibular areas, along with trace edema of the lowe...
Source: Renal Failure - March 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response.
Authors: Deng F, Zhang J, Li Y, Wang W, Hong D, Li G, Feng J Abstract Immunoglobulin A nephropathy (IgAN) is characterized by mesangial IgA and IgG co-deposition. As the clinical course of IgAN is highly variable, a lot of patients will eventually develop to end-stage renal disease (ESRD) within years. Hirudin, a potent and specific thrombin inhibitor, has been reported to treat IgAN with hematuria, but the mechanism is unclear. Our study aims to explore the potential of hirudin and the underlying mechanism in the treatment of IgAN. The establishment of IgAN model was set up in rats through oral and intravenous imm...
Source: Renal Failure - March 20, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Greetings to the readers.
Authors: Fülöp T PMID: 30747027 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal structural image processing techniques: a systematic review.
CONCLUSIONS: A medical image analysis method should provide an auto-adaptive and no external-human action dependency. In addition, since medical systems should have special characteristics such as high accuracy and reliability then clinical validation is highly recommended. New high-quality studies based on Moore neighborhood contour tracking method for glomeruli segmentation and using powerful texture analysis techniques such as the local binary pattern are recommended. PMID: 30747036 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis.
Authors: Jang HN, Park HJ, Cho HS, Bae E, Lee TW, Chang SH, Park DJ Abstract Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the prognosis. We used LODS score to predict prognosis of AKA. We retrospectively reviewed the medical records of 46 patients who were diagnosed as AKA in our hospital. The mean LODS score was 6.3. The probability of mortality based on the LODS score was...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease - a randomized double blind crossover study.
CONCLUSIONS: Statin may have a small but potentially beneficial effect on serum hepcidin, which may lead to improvement of anemia control in CKD patients. PMID: 30741616 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hemoglobin targets for the anemia in patients with dialysis-dependent chronic kidney disease: a meta-analysis of randomized, controlled trials.
This article aims to establish the suitable hemoglobin in order to provide clinical guidance. METHODS: MEDLINE, EmBase, the Cochrane Library and other databases were searched with both MeSH terms and keywords to gather randomized controlled trials that assessed all-cause mortality, cardiovascular events, fistula thrombosis, infectious diseases and transfusion among dialysis-dependent patients using erythropoiesis-stimulating agents. The meta-analysis was accomplished via Revman 5.3 version. FINDINGS: Totally, nine eligible studies were included, with study subjects involving 3228 patients. There was a significantly...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats.
Authors: Zhang J, Tang L, Li GS, Wang J Abstract The present study aimed to explore the protective mechanism of curcumin-precondition in renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided into Sham, IRI, and Curcumin groups (n = 10). The model of IRI was induced by clamping the left renal artery for 45 min followed by 24 h reperfusion with the contralateral nephrectomy. ELISA was used to examine the expression of Cr, BUN, IL-8, TNF-α, and IL-6 in the serum; RT-PCR was used to detect the mRNA level of IL-8,TNF-α, and IL-6 in the kidney; ...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The incidence, risk factors, and clinical outcomes of acute kidney injury (staged using the RIFLE classification) associated with intravenous acyclovir administration.
Authors: Lee EJ, Jang HN, Cho HS, Bae E, Lee TW, Chang SH, Park DJ Abstract Intravenous (IV) acyclovir is commonly administered medication for viral infection but is well known for its nephrotoxicity. However, there was no study for incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV acyclovir administration. We retrospectively reviewed the medical records of 287 patients who were medicated IV acyclovir from January 2008 to May 2013 in Gyeongsang National University Hospital. All had documented medical histories and underwent medical review. Demographic data, risk factors,...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The cartonectin levels at different stages of chronic kidney disease and related factors.
Authors: Yavuz YC, Altınkaynak K, Sevinc C, Ozbek Sebin S, Baydar I Abstract INTRODUCTION: Cartonectin was defined as a new adipokine released from rat and human adipocyte tissues, which is also known as CORS 26 or CTRP3 protein. Although there are several studies investigating the effects of cartonectin with obesity, anti-inflammatory mechanisms, and cardioprotective effects, there is no study about the effects of cartonectin in patients with chronic kidney disease yet. We aimed to investigate cartonectin levels in predialysis and dialysis patient groups, in other words, at different stages of chronic kidney dise...
Source: Renal Failure - February 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Review of the efficacy of AST-120 (KREMEZIN ®) on renal function in chronic kidney disease patients.
Review of the efficacy of AST-120 (KREMEZIN®) on renal function in chronic kidney disease patients. Ren Fail. 2019 Nov;41(1):47-56 Authors: Asai M, Kumakura S, Kikuchi M Abstract AST-120 (KREMEZIN®) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces. Uremic toxins such as indoxyl sulfate and p-cresyl sulfate are abundant in the blood of chronic kidney disease (CKD) patients and are related to the progression of both CKD and cardiovascular disease. AST-120 was approved in Japan i...
Source: Renal Failure - February 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats.
Authors: Lee TW, Bae E, Kim JH, Jang HN, Cho HS, Chang SH, Park DJ Abstract The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intragastrically injected for control group. ABGE was intragastrically injected for garlic group. Ten mg/kg of colistin was intraperitoneally injected for 6 consecutive days for colistin group. One percent of ABGE was done 30&thinsp...
Source: Renal Failure - February 6, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Authors: Hou J, Ding J, Li L, Peng Y, Gao X, Guo Z Abstract Sirtuin 1 (SIRT1), an NAD+-dependent deacylase, has been identified to be associated with renal tubular inflammatory conditions and metabolic disorders, which are risk factors of nephrolithiasis. To further confirm the role of the SIRT1 in kidney stone formation, the expression of SIRT1 was analyzed based on a mouse model and the genetic polymorphisms of SIRT1 gene was compared between patients with kidney stones and controls. The calcium oxalate (CaOx) crystal-induced renal injury model was established to analyzed the expression of SIRT1 in the kidney tis...
Source: Renal Failure - February 6, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of prophylactic antibiotics before peritoneal dialysis catheter implantation on the clinical outcomes of peritoneal dialysis patients.
CONCLUSIONS: Our study does not show any beneficial effect of antibiotic prophylaxis in reducing the postoperative peritonitis. PMID: 30706749 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 3, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research