Serum NGAL and FGF23 may have certain value in early diagnosis of CIN.
CONCLUSIONS: NGAL and FGF23 may have certain value in early diagnosis of CIN. PMID: 30278796 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical and pathologic characteristics of pauci-immune anti-myeloperoxidase antibody associated glomerulonephritis with nephrotic range proteinuria.
CONCLUSIONS: Pauci-immune ANCA GN with nephrotic proteinuria do not have more severe hypoalbuminemia, hypercoagulability or hyperlipidemia than patients without nephrotic proteinuria. Non-selective proteinuria might be the reason. However, pauci-immune ANCA GN with nephrotic proteinuria have more prevalent crescentic category in histopathology, higher incidence of AKI, gross hematuria and poorer renal prognosis despite of good sensitivity to therapy of proteinuria. PMID: 30278797 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil.
Authors: Brito DJA, Dos Santos EM, Dias RSC, Calado IL, Silva GEB, Lages JS, Monteiro Júnior FDC, Dos Santos AM, Salgado Filho N Abstract Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine ...
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Which is the most powerful adverse factor for autogenous access patency between diabetes and high arterial calcification burden?
Authors: Georgiadis GS, Argyriou C, Kantartzi K, Georgakarakos EI PMID: 30278807 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between MPO-463G   >  A polymorphism and chronic kidney disease: a meta-analysis.
CONCLUSIONS: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed. PMID: 30278820 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro.
CONCLUSIONS: ApI pretreatment can protect renal function against I/R injury and prevent renal tubular cells from apoptosis in vivo and in vitro which might through PI3K/Akt mediated mitochondria-dependent apoptosis signaling pathway. PMID: 30278824 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease.
CONCLUSIONS: Hemodialysis procedure contributes to inflammation and oxidative stress. PMID: 30277113 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
CONCLUSION: The expression of MALAT1 is increased in renal ischemia-reperfusion injury. It is likely that MALAT1 inhibits the hypoxia-induced inflammatory response through the NF-κB pathway. PMID: 30277425 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical and genetic analysis of distal renal tubular acidosis in three Chinese children.
CONCLUSIONS: We report the clinical and molecular characteristics of dRTA patients from China. The four novel mutations detected in our study extend the spectrum of gene mutations associated with primary dRTA. Furthermore, our study confirms the effect of early treatment in improving growth for dRTA patient and provides insight into the effects of rhGH on dRTA patients who were diagnosed late and exhibiting a persistent growth delay despite appropriate therapy. PMID: 30230413 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 20, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway.
In this study, we planned to clarify the mechanism of mTOR regulation of podocyte autophagy and the effect of rapamycin (RAPA). METHODS: All rats were randomly divided into normal control group (n = 8), DN group (n = 8), and RAPA group (n = 8). Blood and urine samples were collected at the 4th, 8th, and 12th weeks of the experiment. The serum creatinine (Scr), urine volume levels, and the 24 h urine protein (UP) levels were examined. The nephrin, podocin, mTOR, ribosomal S6 kinase 1 (S6K1), and autophagy marker light chain 3 (LC3II) expression levels were evaluated by im...
Source: Renal Failure - September 13, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum phosphate level at initiation of dialysis is associated with all-cause mortality: a multicenter prospective cohort study.
Authors: Owaki A, Inaguma D, Aoyama I, Inaba S, Koide S, Ito E, Takahashi K, Hayashi H, Hasegawa M, Yuzawa Y, AICOPP group Abstract INTRODUCTION: As glomerular filtration rate (GFR) decreases, serum phosphate level increases. Previous reports indicated that serum phosphate level was associated with mortality in patients on dialysis. However, few reports have examined the association using dialysis initiation as the baseline period. METHODS: This was a multicenter prospective cohort analysis including 1492 patients. Patients were classified into four quartiles based on the serum phosphate level at dialysis initi...
Source: Renal Failure - August 30, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study.
This study investigated the antioxidant effects of whortleberry against cisplatin-induced nephrotoxicity in rats. MATERIAL AND METHODS: This study included 48 female Sprague-Dawley rats weighing 263.68 ± 8.29 g. The rats were divided into the following six groups, with eight rats in each group: control, ethanol control, whortleberry control, cisplatin control, 16 mg/kg cisplatin +100 mg/kg whortleberry, and 16 mg/kg cisplatin +200 mg/kg whortleberry groups. Biochemical analysis was performed by measuring total oxidant status and total antioxidant status, histopath...
Source: Renal Failure - August 23, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Low-intensity pulsed ultrasound in combination with SonoVue induces cytotoxicity of human renal glomerular endothelial cells via repression of the ERK1/2 signaling pathway.
CONCLUSIONS: LIPUS combined with SonoVue induces cytotoxicity of HRGECs via repression of the ERK1/2 signaling pathway. PMID: 30122107 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 22, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro.
This study aimed to explore the protective effects of DIM on renal fibrosis. Unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models were established. The models were then treated with DIM for the assessment of its anti-fibrotic effects and mechanisms. Results of HE and Masson staining showed that DIM reduced kidney injury and production of interstitial collagens fibrosis. CTS also inhibited expression of fibronectin, collagen-1 but retain E-cadherin in the UUO model. Furthermore, DIM suppressed local fibroblast activation, as ev...
Source: Renal Failure - August 14, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors for BK virus infection in living-donor renal transplant recipients: a single-center study from China.
Authors: Li P, Cheng D, Wen J, Xie K, Li X, Ni X, Ji S, Chen J Abstract OBJECTIVES: BK virus (BKV) infection has become one of the main complications in renal transplant recipients (RTRs) with the arrival of newer potent immunosuppressive agents. However, reports on the epidemiology of BKV infection and risk factors in Chinese population after renal transplantation are scarce. METHODS: From June 2015 to July 2016, living-donor renal transplant recipients (LDRTRs) who routinely received the quantitative BKV DNA testing of urine and plasma samples using quantitative real-time polymerase chain reaction (PCR) for t...
Source: Renal Failure - July 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urinary protein and renal prognosis in idiopathic membranous nephropathy: a multicenter retrospective cohort study in Japan.
Authors: Yamaguchi M, Ando M, Katsuno T, Tsuboi N, Maruyama S Abstract BACKGROUND: Several studies have revealed a relationship between proteinuria and renal prognosis in idiopathic membranous nephropathy (IMN). The benefit of achieving subnephrotic proteinuria (
Source: Renal Failure - July 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Safety and efficacy of retrograde intrarenal surgery for the treatment of renal stone in solitary kidney patients.
CONCLUSION: RIRS is a safe and effective procedure for the treatment of renal stones in patients with solitary kidneys. RIRS did not adversely affect renal function at either the short-term or the long-term follow-up. PMID: 30040518 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 25, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions.
Authors: Ceylan B, Ozansoy M, Kılıç Ü, Yozgat Y, Ercan Ç, Yıldız P, Aslan T Abstract OBJECTIVE: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. METHODS: Twenty-eight Wistar rats were divided into four groups comprised of control, colistin, NAC, and colistin-NAC co-treatment, respectively. Serum creatinine and urine N-acetyl-β-d-glucosaminidase (NAG) levels were measured at different time intervals. Histological changes, apoptosis, total oxidant and antioxidant status, a...
Source: Renal Failure - July 24, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Are there any new reliable markers to detect renal injury in obese children?
Authors: Bostan Gayret Ö, Taşdemir M, Erol M, Tekin Nacaroğlu H, Zengi O, Yiğit Ö Abstract AIM: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. METHODS: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were...
Source: Renal Failure - July 24, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diabetes decreases patency of tunneled catheters in hemodialysis patients after first effective thrombolysis with urokinase.
CONCLUSIONS: Patients with diabetes are at higher risk of recurrent catheter-related thrombosis and therefore may require more aggressive anticoagulation therapy for its prevention. PMID: 30010473 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations.
CONCLUSIONS: It should not be forgotten that one of the causes of systemic complaints linked to acute toxicity exposed to the OP compound of fenthion may be cellular injury to glomerular and tubular structures in the kidneys. PMID: 30012025 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant.
CONCLUSIONS: Our results demonstrated a correlation between the UGT1A9 1399 C > T polymorphism and MPA pharmacokinetics among renal transplant patients. Determination of UGT1A9 polymorphism may help to achieve target of MPA blood concentrations. PMID: 30012031 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy.
Authors: Cho AY, Yoon HJ, Lee KY, Sun IO Abstract OBJECTIVE: The aim of this study was to investigate the clinical characteristics of sepsis-induced acute kidney injury (AKI) in patients undergoing continuous renal replacement therapy (CRRT). METHODS: From 2011 to 2015, we enrolled 340 patients who were treated with CRRT for sepsis at the Presbyterian Medical Center. In all patients, CRRT was performed using the PRISMA platform. We divided these patients into two groups (survivors and non-survivors) according to the 28-day all-cause mortality. We compared clinical characteristics and analyzed the predictors of ...
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A meta-analysis of the association between diabetic patients and AVF failure in dialysis.
Authors: Yan Y, Ye D, Yang L, Ye W, Zhan D, Zhang L, Xiao J, Zeng Y, Chen Q Abstract PURPOSE: The most preferable vascular access for patients with end-stage renal failure needing hemodialysis is native arteriovenous fistula (AVF) on account of its access longevity, patient morbidity, hospitalization costs, lower risks of infection and fewer incidence of thrombotic complications. Meanwhile, according to National Kidney Foundation (NKF)̸Dialysis Out-comes Quality Initiative (DOQI) guidelines, AVF is more used than before. However, a significant percentage of AVF fails to support dialysis therapy due to lack of adeq...
Source: Renal Failure - May 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1.
CONCLUSIONS: Combination of sildenafil and gemfibrozil can be used in treatment of cisplatin-induced nephrotoxicity. HO-1 is a promising target for prevention and/or treatment of cisplatin-induced nephrotoxicity. PMID: 29707997 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 2, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy.
This study was determined to explore the effect of acteoside on mesangial injury underlying Th22 cell disorder in IgA nephropathy. Serum Th22 cells and urine total protein of patients with IgA nephropathy were measured before and after six months treatment of Rehmannia glutinosa acteoside or valsartan. Chemotactic assay and co-culture assay were performed to investigate the effect of acteoside on Th22 cell chemotaxis and differentiation. The expression of CCL20, CCL22 and CCL27 were analyzed. To explore the effect of acteoside on mesangial cell injury induced by inflammation, IL-1, IL-6, TNF-α and TGF-β1 were te...
Source: Renal Failure - May 2, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Detection of DKD stage 1 and treatment are essential.
Authors: Futrakul N, Futrakul P PMID: 29667906 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 19, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Management of staghorn renal stones.
Authors: Diri A, Diri B Abstract Staghorn stones are large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system. Although kidney stones are commoner in men, staghorn stones are less often reported in men compared to women and they are usually unilateral. Due to the significant morbidity and potential mortality attributed to staghorn stones, prompt assessment and treatment is mandatory. Conversely, conservative treatment has been shown to carry a mortality rate of 28% in 10-year period and 36% ris...
Source: Renal Failure - April 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Oxidative stress, NOx/l-arginine ratio and glutathione/glutathione S-transferase ratio as predictors of 'sterile inflammation' in patients with alcoholic cirrhosis and hepatorenal syndrome type II.
Authors: Nickovic VP, Miric D, Kisic B, Kocic H, Stojanovic M, Buttice S, Kocic G Abstract Continuous intake of alcohol leads to liver cirrhosis because of imbalance of oxidative stress/antioxidative defense and chronic 'sterile inflammation'. Hepatorenal syndrome (HRS) is the most severe complication of liver cirrhosis. The aim of our study was to assess: (1) the oxidative stress/antioxidative defense markers such as malondialdehyde (MDA), oxidative glutathione (GSH) and glutathione S-transferase (GST), (2) inflammation [C-reactive protein (CRP)], and (3) nitrate/nitrite levels (NOx) and its substrate L-arginine l...
Source: Renal Failure - April 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level.
CONCLUSION: We found that the G allele of chemerin rs17173608 compared to T allele decreased the risk of ESRD, and there was a significant association between chemerin and vaspin variants with plasma MDA level in a sample of the Iranian population. PMID: 29644922 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 15, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of the montreal cognitive assessment and the mini-mental state examination as screening tests in hemodialysis patients without symptoms.
We examined the cognitive function in hemodialysis (HD) patients and compared the Korean versions of the Montreal Cognitive Assessment (K-MoCA) and of the Mini-Mental State Examination (K-MMSE) to identify the better cognitive screening instrument in these patients. Thirty patients undergoing hemodialysis and 30 matched reference group of apparently healthy control were included. All subjects underwent the K-MoCA, K-MMSE and a neuropsychological test battery to measure attention, visuospatial function, language, memory and executive function. All cognitive data were converted to z-scores with appropriate age and education ...
Source: Renal Failure - April 12, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diabetic retinopathy may predict the renal outcomes of patients with diabetic nephropathy.
In this study, we aimed to clarify the relationship between DR and the progression of DN in patients with T2DM. METHODS: In the cross-section study, 250 patients with T2DM and biopsy-proven DN were divided into two groups: 130 in the DN without DR group (DN group) and 120 in the DN + DR group. Logistic regression analysis was performed to identify risk factors for DR. Of the above 250 patients, 141 were recruited in the cohort study who received follow-up for at least 1 year and the influence of DR on renal outcome was assessed using Cox regression. Renal outcome was defined as the progression to end-stag...
Source: Renal Failure - April 12, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A comprehensive analysis of Wnt/ β-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer.
In conclusion, As2O3 may have a significant effect on the Wnt/β-catenin signaling pathway for renal cancer treatment. The potential key DEGs are expected to be used as therapeutic targets. PMID: 29633893 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 12, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

An update on clinical significance of use of THSD7A in diagnosing idiopathic membranous nephropathy: a systematic review and meta-analysis of THSD7A in IMN.
CONCLUSIONS: The prevalence of THSD7A is more common in the PLA2R-negative patients than the IMN patients. Screening for malignancies in THSD7A-positive MN patients is recommended. PMID: 29623759 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 9, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Characteristics of patients with coexisting IgA nephropathy and membranous nephropathy.
Authors: Chen P, Shi SF, Qu Z, Zhao N, Xie XF, Lv JC, Liu LJ, Zhang H Abstract BACKGROUND: Coexistence of IgA nephropathy (IgAN) and membranous nephropathy (MN) in the same patient is rare. Few studies have reported the clinical and pathological features of patients with combined IgAN and MN (IgAN-MN). METHODS: The clinico-pathological features, levels of galactose-deficient IgA1 (Gd-IgA1) and autoantibodies against M-type transmembrane phospholipase A2 receptor (anti-PLA2R) in sera were compared among IgAN-MN, IgAN, and MN patients. RESULTS: Twenty-six patients with biopsy-proven IgAN-MN were enrolled. The...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin.
CONCLUSIONS: Our results demonstrated that ATRA could ameliorate glomerulosclerosis and proteinuria in GS, which may be related to suppressed expression of TRPC6. PMID: 29619864 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up.
In conclusion, KTR without previous vascular events have quite low cardiovascular/CVE rate within 1-year follow-up. VC evaluated as AoAC on pretransplant chest X-ray together with recipient eGFRdischarge could be related to kidney function in one-year follow-up. PMID: 29619867 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients.
Authors: Fayed A, El Nokeety MM, Heikal AA, Abdulazim DO, Naguib MM, Sharaf El Din UAA, Vascular Calcification Group (VCG) Abstract Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many pathologic sequences of CKD. The aim was to evaluate IR in pre-dialysis CKD patients looking for a possible association to mineral metabolism among CKD patients. A total of 100 stage 3-5 CKD patien...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Platelet indices and stroke.
Authors: Yildirim T, Akin F, Altun I, Yildirim SE, Basaran O, Soylu MO PMID: 29619869 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis.
Authors: Liu X, Zhai T, Ma R, Luo C, Wang H, Liu L Abstract OBJECTIVES: Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. METHODS: Pubmed, Embase, the Cochrane library, CBM were searched for randomized controlled trials (RCTs) that assessed the efficiency of lowering serum uric acid therapy on the progression of CKD without language restriction. Summary estimates o...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients.
CONCLUSIONS: Greater ARV was independently associated with increased risk of cardiovascular mortality in HD patients. Age and IDWG were independent related factors for ARV. PMID: 29619872 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of Gelofusine against cRGD-siRNA-induced nephrotoxicity in mice.
Authors: Liao W, Qin Y, Liao L, Cen B, Wu Z, Wei Y, Wang Z, Li G, Ji A Abstract Based on successful targeting to the αvβ3 integrin of cyclic arginine-glycine-aspartic acid (cRGD), cRGD-conjugated small interfering RNA (siRNA) exhibits tumor targeting and has become a new treatment strategy for solid tumors. However, the nephrotoxicity caused by its renal retention limits its clinical application. Here, we evaluated the protective effect of Gelofusine against cRGD-conjugated siRNA-induced nephrotoxicity in mice. Male Kunming mice (six per group) were either co-injected with Gelofusine and cRGD-siRNA or in...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Inhibitory effects of taraxasterol and aqueous extract of Taraxacum officinale on calcium oxalate crystallization: in vitro study.
Authors: Yousefi Ghale-Salimi M, Eidi M, Ghaemi N, Khavari-Nejad RA Abstract OBJECTIVE: We investigated and compared the effects of taraxasterol, aqueous extract of T. officinale (AET) aerial part, and potassium citrate (PC) on calcium oxalate (CaOx) crystallization in vitro. MATERIALS AND METHODS: CaOx crystallization was induced by adding sodium oxalate to synthetic urine. Taraxasterol (2.5, 5, 7.5 and 12.5 μg/mL), extract (1, 2, 4 and 8 mg/mL), and PC (100, 150, 200 and 350 mg/mL) were subjected to anti-crystallization activities. The absorbance and %inhibition of nucleation of CaOx c...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Measurement of daily sodium excretion in patients with chronic kidney disease; special reference to the difference between the amount measured from 24  h collected urine sample and the estimated amount from a spot urine.
Measurement of daily sodium excretion in patients with chronic kidney disease; special reference to the difference between the amount measured from 24 h collected urine sample and the estimated amount from a spot urine. Ren Fail. 2018 Nov;40(1):238-242 Authors: Amano H, Kobayashi S, Terawaki H, Ogura M, Kawaguchi Y, Yokoo T Abstract It is important to grasp a patient's daily sodium intake in the management of chronic kidney disease, as sodium intake is widely recommended at 6 g/day or less. There are multiple equations widely known for estimating the daily sodium excretion from a spot uri...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding.
Authors: Soni H, Kaminski D, Gangaraju R, Adebiyi A Abstract Acute kidney injury (AKI), a significant complication of cisplatin chemotherapy is associated with reactive oxygen species (ROS)-dependent renal cell death, but the cellular targets of ROS in cisplatin nephrotoxicity are not fully resolved. Here, we investigated cisplatin-induced oxidative renal damage and tested the hypothesis that ROS-dependent shedding of death activator Fas ligand (FasL) occurs in cisplatin nephropathy. We show that intraperitoneal injection of sulfobutyl ether-β-cyclodextrin (Captisol™)-solubilized cisplatin elevated the l...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.
CONCLUSIONS: Our findings support the clinical Treg defects in CKD patients with glomerular diseases, and the rationale of evaluating low-dose IL-2 treatment for selectively modulating CD4+ Tregs. PMID: 29619880 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Salvia przewalskii extract of total phenolic acids inhibit TLR4 signaling activation in podocyte injury induced by puromycin aminonucleoside in vitro.
CONCLUSIONS: SPE protects podocytes from PAN-induced injury at least partly through inhibiting TLR4 signaling. SPE is as strong as tacrolimus in inhibiting TLR4 signaling in podocytes. PMID: 29619899 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of mitofilin in left ventricular hypertrophy in hemodialysis patients.
Authors: Wu QS, He Q, He JQ, Chao J, Wang WY, Zhou Y, Lou JZ, Kong W, Chen JF Abstract Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to investigate the relationship between mitofilin and LVH in HD patients. A total of 98 HD patients and 32 healthy controls were included in the study. Serum N-terminal proBNP (NT-proBNP), endothelin-1 (ET-1), an...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Etiological analysis of graft dysfunction following living kidney transplantation: a report of 366 biopsies.
CONCLUSIONS: A biopsy is helpful for the diagnosis of graft dysfunction. De novo or recurrent renal disease, represented by IgAN, is a major cause of graft dysfunction following living kidney transplantation. PMID: 29619905 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Low lean tissue mass can be a predictor of one-year survival in hemodialysis patients.
CONCLUSIONS: Sarcopenia defined as decreased LTI, is a relatively common condition among patients undergoing maintenance hemodialysis, it can also be associated with a lower one-year survival rate. Decreased lean tissue mass can be associated with old age, lower IGF-1 levels and higher IL-6 levels. Body composition assessment may provide prognostic data for hemodialysis patients. PMID: 29620449 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research