The serum levels of gasdermin D in uremic patients and its relationship with the prognosis: a prospective observational cohort study
CONCLUSION: Serum GSDMD levels were remarkably elevated in patients with ESKD with moderate/severe calcification. In addition, serum levels of GSDMD could be a potential predictive biomarker of moderate/severe VC and prognosis in patients with ESKD.PMID:38486504 | DOI:10.1080/0886022X.2024.2312534 (Source: Renal Failure)
Source: Renal Failure - March 15, 2024 Category: Urology & Nephrology Authors: XiaPing Zhang Bo Yang Source Type: research

Long-term mortality in patients with end-stage renal disease undergoing hemodialysis and peritoneal dialysis: a propensity score matching retrospective study
CONCLUSIONS: This study found that long-term mortality rates were higher in the PD group than that in the HD group, indicating that HD may be superior to PD.PMID:38482569 | DOI:10.1080/0886022X.2024.2321320 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Pengjie Zhang Liru Xun Nan Bao Ding Tong Bin Duan Du Peng Source Type: research

Efficacy and safety of Mahuang Fuzi and Shenzhuo Decoction for treatment of primary membranous nephropathy: a multicenter prospective trial
CONCLUSIONS: This trial establishes the efficacy of MFSD as a treatment modality for membranous nephropathy. MFSD demonstrates a favorable side effect profile, and remission rates are consistent across patients, irrespective of HIST and age categories.PMID:38482580 | DOI:10.1080/0886022X.2024.2320834 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Naiqian Zhang Hanxue Jiang Haoran Dai Shuxian Huang Qihan Zhao Na Zhang Wenbin Liu Zhaocheng Dong Yu Gao Xuan Dong Yuehong Hu Fanyu Hou Hongliang Rui Qingquan Liu Baoli Liu Source Type: research

Analysis of chronic kidney disease epidemiology in Kazakhstan using nationwide data for 2014-2020 and forecasting future trends of prevalence and mortality for 2030
This study aims to examine the epidemiology of CKD in Kazakhstan and to project future trends in CKD prevalence and mortality by 2030. The retrospective analysis was performed on a database acquired from the Unified National Electronic Health System for 703,122 patients with CKD between 2014 and 2020. During the observation period, 444,404 women and 258,718 men were registered with CKD, 459,900 (66%) were Kazakhs and 47% were older than 50. The incidence rate notably decreased: 6365 people per million population (PMP) in 2014 and 4040 people PMP in 2020. The prevalence changed from 10,346 to 38,287 people PMP, and the mort...
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Gulnur Zhakhina Kamilla Mussina Sauran Yerdessov Arnur Gusmanov Yesbolat Sakko Valdemir Kim Dmitriy Syssoyev Meruyert Madikenova Ainur Assan Zhanat Kuanshaliyeva Duman Turebekov Kuanysh Yergaliyev Bolat Bekishev Abduzhappar Gaipov Source Type: research

The relationship between thiamin, folic acid and cognitive function in a rat model of uremia
Ren Fail. 2024 Dec;46(1):2329257. doi: 10.1080/0886022X.2024.2329257. Epub 2024 Mar 14.ABSTRACTEnd-stage renal disease is a worldwide health burden, but the pathogenesis of uremia-associated cognitive impairment (CI) is poorly recognized. We hypothesized that uremia brings about deficiency of thiamin and folic acid and causes CI by inducing oxidative stress. Therefore, 24 Sprague-Dawley rats were randomly divided into two groups: a 5/6 nephrectomy group (n = 12) and a sham-operated group (n = 12). The Morris water maze was used to assess the cognitive function eight weeks post-surgery, and serum levels of thiamin, folic ac...
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Yifei Lu Chenqi Xu Kewei Xie Bingru Zhao Minzhou Wang Cheng Qian Xuemei Chen Leyi Gu Wangshu Wu Renhua Lu Source Type: research

Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation
CONCLUSION: Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. While the trends discerned from the literature emerging opportunities in diagnostic innovation, renal microcirculation research, and precision medicine interventions, their translation to clinical practice is anticipated to be a deliberate process.PMID:38482598 | DOI:10.1080/0886022X.2024.2329249 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Bing Wang Mengting Xu Sunjing Fu Yingyu Wang Hao Ling Yuan Li Bingwei Li Xueting Liu Qin Ouyang Xiaoyan Zhang Ailing Li Xu Zhang Mingming Liu Source Type: research

TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF- κB signaling pathway
CONCLUSION: TAK-242 can improve oxidative stress, mitochondrial dysfunction, and inflammatory response by inhibiting the activity of TLR4/NF-κB signaling pathway, thereby preventing rats from SA-AKI.PMID:38482886 | DOI:10.1080/0886022X.2024.2313176 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Yan-Mei Xia Yu-Qian Guan Ji-Fang Liang Wei-Dong Wu Source Type: research

Long-term mortality in patients with end-stage renal disease undergoing hemodialysis and peritoneal dialysis: a propensity score matching retrospective study
CONCLUSIONS: This study found that long-term mortality rates were higher in the PD group than that in the HD group, indicating that HD may be superior to PD.PMID:38482569 | DOI:10.1080/0886022X.2024.2321320 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Pengjie Zhang Liru Xun Nan Bao Ding Tong Bin Duan Du Peng Source Type: research

Efficacy and safety of Mahuang Fuzi and Shenzhuo Decoction for treatment of primary membranous nephropathy: a multicenter prospective trial
CONCLUSIONS: This trial establishes the efficacy of MFSD as a treatment modality for membranous nephropathy. MFSD demonstrates a favorable side effect profile, and remission rates are consistent across patients, irrespective of HIST and age categories.PMID:38482580 | DOI:10.1080/0886022X.2024.2320834 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Naiqian Zhang Hanxue Jiang Haoran Dai Shuxian Huang Qihan Zhao Na Zhang Wenbin Liu Zhaocheng Dong Yu Gao Xuan Dong Yuehong Hu Fanyu Hou Hongliang Rui Qingquan Liu Baoli Liu Source Type: research

Analysis of chronic kidney disease epidemiology in Kazakhstan using nationwide data for 2014-2020 and forecasting future trends of prevalence and mortality for 2030
This study aims to examine the epidemiology of CKD in Kazakhstan and to project future trends in CKD prevalence and mortality by 2030. The retrospective analysis was performed on a database acquired from the Unified National Electronic Health System for 703,122 patients with CKD between 2014 and 2020. During the observation period, 444,404 women and 258,718 men were registered with CKD, 459,900 (66%) were Kazakhs and 47% were older than 50. The incidence rate notably decreased: 6365 people per million population (PMP) in 2014 and 4040 people PMP in 2020. The prevalence changed from 10,346 to 38,287 people PMP, and the mort...
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Gulnur Zhakhina Kamilla Mussina Sauran Yerdessov Arnur Gusmanov Yesbolat Sakko Valdemir Kim Dmitriy Syssoyev Meruyert Madikenova Ainur Assan Zhanat Kuanshaliyeva Duman Turebekov Kuanysh Yergaliyev Bolat Bekishev Abduzhappar Gaipov Source Type: research

The relationship between thiamin, folic acid and cognitive function in a rat model of uremia
Ren Fail. 2024 Dec;46(1):2329257. doi: 10.1080/0886022X.2024.2329257. Epub 2024 Mar 14.ABSTRACTEnd-stage renal disease is a worldwide health burden, but the pathogenesis of uremia-associated cognitive impairment (CI) is poorly recognized. We hypothesized that uremia brings about deficiency of thiamin and folic acid and causes CI by inducing oxidative stress. Therefore, 24 Sprague-Dawley rats were randomly divided into two groups: a 5/6 nephrectomy group (n = 12) and a sham-operated group (n = 12). The Morris water maze was used to assess the cognitive function eight weeks post-surgery, and serum levels of thiamin, folic ac...
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Yifei Lu Chenqi Xu Kewei Xie Bingru Zhao Minzhou Wang Cheng Qian Xuemei Chen Leyi Gu Wangshu Wu Renhua Lu Source Type: research

Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation
CONCLUSION: Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. While the trends discerned from the literature emerging opportunities in diagnostic innovation, renal microcirculation research, and precision medicine interventions, their translation to clinical practice is anticipated to be a deliberate process.PMID:38482598 | DOI:10.1080/0886022X.2024.2329249 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Bing Wang Mengting Xu Sunjing Fu Yingyu Wang Hao Ling Yuan Li Bingwei Li Xueting Liu Qin Ouyang Xiaoyan Zhang Ailing Li Xu Zhang Mingming Liu Source Type: research

TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF- κB signaling pathway
CONCLUSION: TAK-242 can improve oxidative stress, mitochondrial dysfunction, and inflammatory response by inhibiting the activity of TLR4/NF-κB signaling pathway, thereby preventing rats from SA-AKI.PMID:38482886 | DOI:10.1080/0886022X.2024.2313176 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Yan-Mei Xia Yu-Qian Guan Ji-Fang Liang Wei-Dong Wu Source Type: research

Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model
CONCLUSIONS: This study provides evidence that the consumption of a HFD induces modifications in the composition and functionality of the gut microbiome in rats, which may serve as a potential mechanism underlying the relationship between obesity and the progression of kidney function decline.PMID:38469667 | DOI:10.1080/0886022X.2024.2328320 (Source: Renal Failure)
Source: Renal Failure - March 12, 2024 Category: Urology & Nephrology Authors: Akehu Alemasi Lijiang Gu Yilun Zhou Source Type: research