The predictive value of crescents in the disease progression of lupus nephritis based on the 2018 International Society of Nephrology/Renal Pathology Society Revision System: a large cohort study from China.
Conclusion: We proposed that the crescents were not uncommon and had important clinical significance in lupus nephritis. The cutoff point of crescents as prognosticator might be nearly 7.39%. PMID: 32054387 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Successful treatment of cholesterol crystal embolism with anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody: a case report.
Conclusion: Evolocumab may have a beneficial effect on renal involvement in patients with CCE. PMID: 32046605 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A long journey for acute kidney injury biomarkers.
Authors: Oh DJ Abstract Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on underlying conditions. However, it has only marginally declined over the past 25 years. Previous authoritative publications have been pointed out that the lack of useful biomarkers for AKI has limited progress in improving the outcomes of this disorder. The purpose of this paper is to review the recent biomarkers involved in the early detection of AKI and main reasons for the failure to identify new AKI biomar...
Source: Renal Failure - February 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Changes in cardiac output with hemodialysis relate to net volume balance and to inferior vena cava ultrasound collapsibility in critically ill patients.
Authors: Kaptein MJ, Kaptein JS, Nguyen CD, Oo Z, Thwe PP, Thu MB, Kaptein EM Abstract Cardiac output may increase after volume administration with relative intravascular volume depletion, or after ultrafiltration (UF) with relative intravascular volume overload. Assessing relative intravascular volume using respiratory/ventilatory changes in inferior vena cava (IVC) diameters may guide volume management to optimize cardiac output in critically ill patients requiring hemodialysis (HD) and/or UF.We retrospectively studied 22 critically ill patients having relative intravascular volume assessed by IVC Collapsibility ...
Source: Renal Failure - February 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ureteral anastomosis with a polyimide stent in rat kidney transplantation.
Conclusions: The current anastomosis method with polyimide stent causes minimal damage to the ureteral walls and minimizes the possibility of stent migration. Therefore, this method of ureteral anastomosis with the polyimide stent should be explored for its potential benefits in more animal kidney transplantation models, thus providing an alternative for the clinical setting. PMID: 32052680 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Greetings to the readers.
Authors: Fülöp T PMID: 32053032 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between carnitine deficiency and the erythropoietin resistance index in patients undergoing peritoneal dialysis: a cross-sectional observational study.
In this study, the prevalence of carnitine deficiency and the clinical factors associated with carnitine deficiency were investigated in 60 patients undergoing PD. The median age of the patients was 62.5 years (52.5-72.5 years), the proportion of male sex was 44/60 (73.3%), and the median PD period was 24 months (12-45 months). Carnitine deficiency (acyl carnitine/free carnitine ratio>0.4) was detected in 56/60 (93%) patients. Multiple regression analysis showed that the erythropoietin resistance index was independently associated with carnitine deficiency (β = 0.283, p&thi...
Source: Renal Failure - February 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High-dose ulinastatin to prevent late-onset acute renal failure after orthotopic liver transplantation.
Conclusions: Higher dose of ulinastatin (1.6 million U/d) might be preferable to prevent LARF after OLT, and it may contribute to the enhancement of early multiple organ recovery and thus attenuate the incidence of LARF. PMID: 31984833 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.
Conclusion: In developed countries, LND can be diagnosed as early as 3 days after birth. However, diagnosis in the present case was delayed due to the rarity of the disease and the limited number of facilities in Indonesia that offer genetic counseling. Late diagnosis of LND leads to ESRD and irreversible abnormalities. This is the first case of LND presenting with a unique clinical presentation of tophus burst reported in Indonesia. PMID: 31985336 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy.
Authors: Guo Y, Wu X, Liu L, Zhang H, Yang L, Chen W Abstract Objective: To evaluate the clinical efficacy and safety of leflunomide (LEF) combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy (PMN) and changes in anti-PLA2R antibody titers after treatment.Methods: Sixty patients with nephrotic syndrome, biopsy-proven MN and anti-PLA2R antibody positivity were included in this study conducted from December 2017 to February 2019. The patients were randomly divided into an experimental group (n = 30) and a control group (n = 30). The patients in the ...
Source: Renal Failure - January 22, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum osteoprotegerin level is positively associated with peripheral artery disease in patients with peritoneal dialysis.
Authors: Lin WC, Tsai JP, Lai YH, Lin YL, Kuo CH, Wang CH, Hsu BG Abstract Osteoprotegerin (OPG) is a potential biomarker of cardiovascular disease complications and severity. Peripheral arterial disease (PAD) is associated with an increased risk of death in patients on peritoneal dialysis (PD). Therefore, this study aimed to evaluate the relationship between serum OPG levels and PAD by measuring the ankle-brachial index (ABI) of patients on PD. A commercial enzyme-linked immunosorbent assay kit was used to measure OPG values. Left or right ABI values of
Source: Renal Failure - January 19, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.
Authors: Ma H, Ouyang C, Huang Y, Xing C, Cheng C, Liu W, Yuan D, Zeng M, Yu X, Ren H, Yuan Y, Zhang L, Xu F, Cui Y, Ren W, Huang H, Qian H, Fan B, Wang N Abstract Purpose: Microwave ablation (MWA) is feasible for severe renal secondary hyperparathyroidism (SHPT) and primary hyperparathyroidism (PHPT) patients ineligible for parathyroidectomy (PTX). Here we compared the clinical manifestations and characteristics of parathyroid glands in these two groups, and summarized the techniques, safety and efficacy of MWA.Methods: Baseline clinical characteristics, ablation-related techniques, adverse events/complications, a...
Source: Renal Failure - January 15, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Coronary artery bypass grafting vs. drug-eluting stent implantation in patients with end-stage renal disease requiring dialysis.
Authors: Wang Z, Gong Y, Fan F, Yang F, Qiu L, Hong T, Huo Y Abstract Objectives: To evaluate the optimal revascularization strategy for patients with coronary artery disease (CAD) and end stage renal disease (ESRD) in the drug-eluting stent (DES) era.Methods: One hundred and twelve patients with ESRD treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) were enrolled from 2007 to 2017. All patients were dialysis-dependent, of which 26 received CABG and 86 underwent PCI. The primary endpoint was all-cause mortality. Secondary endpoints were major adverse cardiovascular even...
Source: Renal Failure - January 12, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between epidermal growth factor (EGF) and EGF receptor gene polymorphisms and end-stage renal disease and acute renal allograft rejection in a Korean population.
Conclusion: Our findings suggest that SNPs in the EGF and EGFR gene may be associated with the risk of ESRD and AR development in the Korean population. PMID: 31906817 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 8, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models.
Conclusion: These results suggested that embryonic metanephroi can grow into tissues with mature kidney structure under acute nephrotoxic, and the graft microenvironment was effective in inhibiting the progression of AKI, which provides a new approach for the treatment of acute renal injury. PMID: 31900008 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 5, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Timing of initiation of renal replacement therapy in acute kidney injury: an updated meta-analysis of randomized controlled trials.
Authors: Zhang L, Chen D, Tang X, Li P, Zhang Y, Tao Y Abstract Purpose: The results from randomized controlled trials (RCTs) concerning the timing of initiation of renal replacement therapy (RRT) for patients with acute kidney injury (AKI) are still inconsistent.Materials and methods: We searched for RCTs, as well as relevant references, focusing on the timing of RRT for AKI patients in the Medline, Embase, Cochrane Library, Google Scholar and Chinese databases from their inception to December 2018.Results: We included 18 RCTs from 1997 to 2018 involving 2856 patients. Pooled analyses of all RCTs showed no signifi...
Source: Renal Failure - January 4, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of the performance of a chemiluminescence assay and an ELISA for detection of anti-GBM antibodies.
Conclusions: The detection of anti-GBM antibodies with CIA demonstrated good sensitivity and specificity and was in good agreement with our homemade ELISA, which seems better than the commercial ELISA in suspected anti-GBM disease patients. The three assays performed in parallel in the diagnosis of anti-GBM disease patients. PMID: 31885301 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acquired long QT syndrome in chronic kidney disease patients.
Authors: Liu P, Wang L, Han D, Sun C, Xue X, Li G Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The prevalence of acquired long QT syndrome (aLQTS) is high, and various acquired conditions contribute to the prolonged QT interval in patients with CKD. More notably, the prolonged QT interval in CKD is an independent risk factor...
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of hydrocortisone on the 28-day mortality of patients with septic acute kidney injury.
Authors: Ying P, Yang C, Wu X, Cai Q, Xin W Abstract Objectives: To evaluate the efficacy of hydrocortisone in patients with septic acute kidney injury (SAKI).Methods: This retrospective cohort study consisted of all consecutive patients with SAKI who were admitted to the Taizhou First People's Hospital from March 2016 to February 2018. The patients who were treated with usual care including antibiotics, fluid resuscitation, and blood glucose control were regarded as the control group, and those received add-on hydrocortisone by the clinicians' discretion was considered in the intervention group. Hydrocortisone was...
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Greetings to the readers.
Authors: Fülöp T PMID: 31880212 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The relationship between hemodialysis mortality and the Chinese medical insurance type.
Authors: Yao X, Chen S, Lei W, Shi N, Lin W, Du X, Zhang P, Chen J Abstract Objectives: In China, there are two major medical insurance models: the Urban Basic Medical Insurance (UBMI) and the New Cooperative Medical Scheme (NCMS). The aim of the present study was to evaluate the association of the medical insurance type of patients undergoing hemodialysis (HD) with their survival.Methods: We retrospectively analyzed the end-stage renal disease adult patients initiating HD between January 2010 and December 2014 in Zhejiang province, followed up through 31 December 2015. Patients who had received HD for over 3&thins...
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High glucose and TGF- β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.
High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells. Ren Fail. 2019 Nov;41(1):762-769 Authors: Huang F, Guo Y, Wang L, Jing L, Chen Z, Lu S, Fu R, Tian L Abstract There are seven endoplasmic reticulum (ER)-resident selenoproteins in human body and they can regulate the inflammation, oxidative stress, and ER stress. We established transforming growth factor-β1 (TGF-β1) or high glucose (HG) induced human mesangial cells (HMCs) fibronectin expression model in vitro. Next, the expression changes of seven ER-...
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of mortality between peritoneal dialysis and hemodialysis in polycystic kidney disease.
Authors: Fang X, Kang M, Chen D, Shen L PMID: 31880215 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Assessment of variation in B-cell receptor heavy chain repertoire in patients with end-stage renal disease by high-throughput sequencing.
Authors: Wang L, Dai Y, Liu S, Lai L, Yan Q, Chen H, Zhang J, Sui W Abstract Background/Aims: End-stage renal disease (ESRD), characterized by progressive loss of rental function during the disease course, has been reported to be correlated with immune dysregulation. To date, a majority of previous studies on immune response to ESRD have been focused on the T-cell response. This prospective study was to assess the B-cell receptor (BCR) heavy chain repertoire in ESRD patients.Materials and methods: A total of 10 ESRD patients and six healthy controls were prospectively enrolled in this study. BCR immunoglobulin heav...
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between longer hospitalization and development of de novo donor specific antibodies in simultaneous liver-kidney transplant recipients.
Conclusion: Longer hospitalization is significantly associated with the development of de novo DSA in SLKT. PMID: 31875761 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal microvascular lesions in lupus nephritis.
Authors: Ding Y, Tan Y, Qu Z, Yu F Abstract Renal microvascular lesions, common in lupus nephritis (LN), are associated with long-term poor outcomes. There are mainly five pathological types of renal microvascular lesions in LN: (1) vascular immune complex deposits (ICD), (2) arteriosclerosis (AS), (3) thrombotic microangiopathy (TMA), (4) non-inflammatory necrotizing vasculopathy (NNV), and (5) true renal vasculitis (TRV). The pathogenesis of renal microvascular lesions in LN remains to be elucidated. The activation and dysfunction of endothelial cells, in addition to the contribution of immune system dysfunction,...
Source: Renal Failure - December 22, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Thromboelastography versus bleeding time for risk of bleeding post native kidney biopsy.
Conclusions: TEG abnormalities in patients with renal dysfunction are variable and fail to predict bleeding during kidney biopsy. The decision to administer DDAVP as a preventive measure during these procedures should be based on clinical judgment only. PMID: 31842662 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effects of vascular access types on the survival and quality of life and depression in the incident hemodialysis patients.
Authors: Kim DH, Park JI, Lee JP, Kim YL, Kang SW, Yang CW, Kim NH, Kim YS, Lim CS Abstract Background: Although arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis (HD), the association between vascular access types and quality of life is not well-known. We investigated the relationships between HD vascular access types and all-cause mortality, health-related quality of life (HRQOL) and the degree of depression in a large prospective cohort.Methods: A total of 1461 patients who newly initiated HD were included. The initial vascular access types were classified into AVF, arteriovenous graf...
Source: Renal Failure - December 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical risk factors and outcomes of massive ascites accumulation after discontinuation of peritoneal dialysis.
Authors: Chang MS, Chen NC, Hsu CY, Huang CW, Lee PT, Chou KJ, Fang HC, Chen CL Abstract Background: Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD), with high morbidity and mortality that requires an early diagnosis for effective treatment. PD withdrawal and bacterial peritonitis are important triggers for the onset of EPS. However, few studies have focused on cases of PD withdrawal without a clinical diagnosis of peritonitis, cirrhosis, or carcinomatosis. We aimed to compare the clinical characteristics and computed tomography (CT) images of patients with or without ...
Source: Renal Failure - December 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical outcomes following the surgery of new autologous arteriovenous fistulas proximal to the failed ones in end-stage renal disease patients: a retrospective cohort study.
Conclusions: The study revealed that the primary and secondary patiencies of the surgery of new AVF proximal to the failed ones were ideal operations to restore failed forearm AVF. PMID: 31814501 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 11, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of acute kidney injury with frailty in elderly population: a systematic review and meta-analysis.
Conclusion: In conclusion, the available best evidence support an association between frailty and AKI among elder patients, thus relevant interventions should be taken among elderly under potential risk of AKI. PMID: 31809623 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal involvement in a silicosis patient - case report and literature review.
Authors: Chen FF, Tang HY, Yu F, Que CL, Zhou FD, Wang SX, Wang GF, Zhao MH Abstract A 43-year-old Chinese man with a silicosis history was admitted to our hospital due to bilateral lower extremity edema for 1 year, exacerbating with hematuria for 2 months. He started working as a coal miner 30 years ago, and was diagnosed as silicosis 3 months ago. Lab tests revealed hematuria 3+, proteinuria 3+, and a serum creatinine value 2.47 mg/dl on routine check. He was diagnosed with focal proliferative IgA nephropathy (IgAN) and acute tubulo-interstitial nephritis by renal biopsy. He was...
Source: Renal Failure - December 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Impact of pretreatment with carnitine and tadalafil on contrast-induced nephropathy in CKD patients.
Conclusions: These results indicate that carnitine and PDE-5 inhibitors may comprise potential therapeutic maneuvers for CIN. PMID: 31797710 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 6, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Correction.
Authors: PMID: 31771388 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between Helicobacter pylori infection and kidney damage in patients with peptic ulcer.
Authors: Pan W, Zhang H, Wang L, Zhu T, Chen B, Fan J Abstract Background: Helicobacter pylori (H. pylori) is relevant to several renal diseases. Our previous research indicates that cytotoxin-associated gene A (CagA) of H. pylori increases secretion of serum immunoglobulin A1 (IgA1) and induces the underglycosylation of IgA1, one of the key factors causing IgA nephropathy. Here, we aimed to study the correlation between H. pylori infection and kidney damage in patients with peptic ulcer, and evaluate the effect of H. pylori eradication on kidney damage.Methods: 14C-urea breath test and rapid urease tests were appl...
Source: Renal Failure - November 23, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Obesity is associated with Henoch-Sch önlein Purpura Nephritis and development of end-stage renal disease in children.
Obesity is associated with Henoch-Schönlein Purpura Nephritis and development of end-stage renal disease in children. Ren Fail. 2019 Nov;41(1):1016-1020 Authors: Zheng X, Chen Q, Chen L Abstract Objectives: To explore the association of obesity with the occurrence of Henoch-Schönlein Purpura Nephritis (HSPN) and development of end-stage renal disease (ESRD) in children with Henoch-Schönlein Purpura (HSP).Methods: This was a retrospective study of 446 pediatric patients with diagnosed HSP. All patients' demographic characteristics, clinical features, and laboratory data were collected fro...
Source: Renal Failure - November 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Endoplasmic reticulum stress participates in the pathophysiology of mercury-caused acute kidney injury.
This study aimed to determinate if HgCl2 causes an AKI course with temporary activation of ERS and if this mechanism is involved in kidney cell death. Male mice were intoxicated with 5 mg/kg HgCl2 and sacrificed after 24, 48, 72, and 96 h of mercury administration. The kidneys of euthanized mice were used to assess the renal function, oxidative stress, redox environment, antioxidant enzymatic system, cell death, and reticulum stress markers (PERK, ATF-6, and IRE1α pathways). The results indicate temporary-dependent renal dysfunction, oxidative stress, and an increase of glutathione-dependent enzymes inv...
Source: Renal Failure - November 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Tight junction protein expression from peritoneal dialysis Effluent.
Conclusion: In PD patients, expression of peritoneal TJ proteins can be estimated from the dialysis effluent and may be used as novel peritoneal biomarkers. PMID: 31724477 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 16, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors and outcomes of acute kidney injury in ventilated newborns.
This study aimed to investigate the occurrence and risk factors of acute kidney injury (AKI) in ventilated newborns.Methods: In total, 139 newborns receiving mechanical ventilation (MV) were reviewed in this retrospective study. The demographic and clinical data were collected. Then, the independent risk factors for AKI were evaluated using univariate and multivariate logistic regression analyses.Results: The incidence rate of AKI was 15.11% (21/139) in ventilated newborns. Univariate analysis showed significant differences in gestational age, birth weight, Apagar scores, the highest oxygen concentration, serum creatinine ...
Source: Renal Failure - November 11, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of anti-C5 antibody on recuperation from ischemia/reperfusion-induced acute kidney injury.
Conclusion: In I/R-induced AKI, the monoclonal anti-C5 complement factor ameliorates intra renal complement activation, decreases local and systemic inflammation and may improve GFR. PMID: 31662004 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 1, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis.
In conclusion, our meta-analysis indicated that AHR rs2066853 gene polymorphism might be associated with an increased susceptibility to oligoasthenotspermia. PMID: 31662023 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 1, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of mammalian target of rapamycin pathway in the pathogenesis of pauci-immune glomerulonephritis.
Conclusion: Our results suggest that mTOR pathway may play role in the pathogenesis of pauci-immune glomerulonephritis, besides targeting this signaling may be an alternative option for those patients. PMID: 31658846 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 30, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Statement of Retraction: The relationship between hemodialysis mortality and the Chinese medical insurance type.
Authors: PMID: 31658849 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 30, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The miR-15a-5p-XIST-CUL3 regulatory axis is important for sepsis-induced acute kidney injury.
Conclusion: The miR-15a-5p-XIST-CUL3 regulatory axis was related to the pathogenesis of sepsis-induced AKI. Highlights Totally, 31 miRNAs were dysregulated between disease and control groups. MiR-15a-5p, miR-15b-5p, and miR-16-5p were involved in mTOR signaling pathway. MiR-16-5p and miR-29b-3p were implicated in PI3K-Akt signaling pathway. The miR-15a-5p-XIST-CUL3 axis was critical for sepsis-induced AKI. PMID: 31658856 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 30, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical outcomes of botulinum toxin A management for neurogenic detrusor overactivity: meta-analysis.
Authors: Wu SJ, Xu YQ, Gao ZY, Wang ZP, Zhao F, Liu L, Wang S Abstract The aim of this work was to evaluate the efficacy and safety of botulinum toxin A (BTX-A) treatment in patients with neurogenic detrusor overactivity. PUBMED, EMBASE, and Cochrane Library were identified on 13 May 2017 to identify relevant randomized controlled trials. All data obtained were analyzed using Stata 12.0. Five randomized controlled trials were included in this study. Compared to placebo, the BTX-A groups had significantly fewer urinary incontinence (UI) episodes per day and per week (BTX-A with 300 U for frequency of UI per d...
Source: Renal Failure - October 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Plasma triglyceride levels and central obesity predict the development of kidney injury in Chinese community older adults.
Authors: Cao Y, Sun G, Liu R, Sun A, Zhang Q, Li Y, Wang L, Chao X, Zhou X, Zhang S, Chen R Abstract Objective: Despite the achievement of blood glucose, blood pressure targets, the risk for kidney injury remains high among older adults. This observational retrospective study investigated whether high TG or high WC contribute to this high residual risk for kidney injury. Methods: A total of 843 elderly from Dongli Community, Tianjin, China, we selected 666 individuals with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and negative microalbuminuria completing a 3-year fol...
Source: Renal Failure - October 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Intrarenal resistive index conundrum: systemic atherosclerosis versus renal arteriolosclerosis.
Authors: Ștefan G, Florescu C, Sabo AA, Stancu S, Mircescu G Abstract Background: We aimed to evaluate the relationship between biopsy-proven kidney lesions, subclinical markers of atherosclerosis and intrarenal resistive index (RRI) in chronic kidney disease (CKD) patients. Methods: This cross-sectional, single-center study prospectively enrolled 44 consecutive CKD patients (57% male gender, 54.1 (95%CI, 49.7-58.6) years, median eGFR 28.1 (15.0-47.7) mL/min) diagnosed by renal biopsy during 6 months in our clinic. RRI, carotid intima-media thickness (IMT), Kauppila score for abdominal aortic calcification ...
Source: Renal Failure - October 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10  years.
Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years. Ren Fail. 2019 Nov;41(1):914-920 Authors: Huang PP, Shu DH, Su Z, Luo SN, Xu FF, Lin F Abstract Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years. Methods: A case-control study was carried out. Seventy-seven ESRF patients with the pr...
Source: Renal Failure - October 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of laboratory parameters and symptoms after parathyroidectomy in dialysis patients with secondary hyperparathyroidism.
Conclusion: PTX is a safe and effective therapy for treating SHPT that is refractory to medical therapies and accompanied by related signs and symptoms in dialysis patients. All three operative techniques were effective in controlling SHPT. PMID: 31573378 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 3, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF- κB, TGF-β and TRPC6.
Conclusion: The combination use of leflunomide and benazepril could improve the renal function and reduce the renal injury of DN rats and could reduce the levels of NF-κb, TGF-β and TRPC6 in both DN rats and high-glucose induced RMCs. PMID: 31552773 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research