Platelet-leukocyte aggregates - a predictor for acute kidney injury after cardiac surgery
Ren Fail. 2021 Dec;43(1):1155-1162. doi: 10.1080/0886022X.2021.1948864.ABSTRACTBACKGROUND: Acute kidney injury (AKI) is one of the most common complications after cardiac surgery. However, effective biomarker used for early diagnosis of AKI has not been identified. Platelet-leukocyte aggregates (PLAs) participate in inflammation and coagulation, leading to vascular lesions and tissue destruction. We designed a prospective study to assess whether PLAs can serve as a good biomarker for early diagnosis of AKI after cardiac surgery.METHODS: Patients with rheumatic heart disease scheduled to undergo valve replacement surgery we...
Source: Renal Failure - July 16, 2021 Category: Urology & Nephrology Authors: Shenghan Yang Xunbei Huang Juan Liao Qin Li Si Chen Chaonan Liu Liqin Ling Jing Zhou Source Type: research

The landscape of renal replacement therapy in Veterans Affairs Medical Center intensive care units
CONCLUSIONS: Within the VA system, ICU-related RRT practice is quite varied. Variation in processes of care, prescription authority, nursing care coordination, medication management, and safety practices present opportunities for developing cross-cutting measures of quality of intensive care RRT that are agnostic of modality choice.PMID:34261420 | DOI:10.1080/0886022X.2021.1949347 (Source: Renal Failure)
Source: Renal Failure - July 15, 2021 Category: Urology & Nephrology Authors: Chandan Vangala Maulin Shah Natasha N Dave Layth Al Attar Sankar D Navaneethan Venkat Ramanathan Susan Crowley Wolfgang C Winkelmayer Source Type: research

Early prediction of acute kidney injury after liver transplantation by scoring system and decision tree
CONCLUSION: Five intraoperative and post-operative factors are independently associated with post-LT AKI rather than pre-operative factors, which indicates that operation technique and post-operative management may more important for the prevention of post-LT AKI. The scoring system and decision tree model could complement each other, and provide quantitative and intuitive prediction tools for clinical practice of early detection of post-LT AKI.PMID:34261422 | DOI:10.1080/0886022X.2021.1945462 (Source: Renal Failure)
Source: Renal Failure - July 15, 2021 Category: Urology & Nephrology Authors: Wang Xin Wang Yi Hui Liu Liu Haixia Lin Dongdong Yingmin Ma Guangming Li Source Type: research

The Effect of Smoking on Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease Patients with Preserved Renal Function
CONCLUSIONS: Patients with ADPKD had more impaired endothelial function and subclinical atherosclerosis compared with control subjects. Smoking may increase the risk of subclinical atherosclerosis in ADPKD patients.PMID:34256663 | DOI:10.1080/0886022X.2021.1949348 (Source: Renal Failure)
Source: Renal Failure - July 14, 2021 Category: Urology & Nephrology Authors: Cuma Bulent Gul Abdulmecit Yildiz Saim Sag Aysegul Oruc Alparslan Ersoy Sumeyye Gullulu Source Type: research

Divergence between serum creatine and cystatin C in estimating glomerular filtration rate of critically ill COVID-19 patients
Ren Fail. 2021 Dec;43(1):1104-1114. doi: 10.1080/0886022X.2021.1948428.ABSTRACTBACKGROUND: The clinical use of serum creatine (sCr) and cystatin C (CysC) in kidney function evaluation of critically ill patients has been in continuous discussion. The difference between estimated glomerular filtration rate calculated by sCr (eGFRcr) and CysC (eGFRcysc) of critically ill COVID-19 patients were investigated in this study.METHODS: This is a retrospective, single-center study of critically ill patients with COVID-19 admitted in intensive care unit (ICU) at Wuhan, China. Control cases were moderate COVID-19 patients matched in ag...
Source: Renal Failure - July 9, 2021 Category: Urology & Nephrology Authors: Yanan Liu Peng Xia Wei Cao Zhengyin Liu Jie Ma Ke Zheng Limeng Chen Xuewang Li Yan Qin Xuemei Li Source Type: research

A validation study of UCSD-Mayo risk score in predicting hospital-acquired acute kidney injury in COVID-19 patients
CONCLUSIONS: We validated the performance of UCSD-Mayo risk score in predicting hospital-acquired AKI in COVID-19 patients was excellent except for patients from ICU or patients with mechanical ventilation.PMID:34233570 | DOI:10.1080/0886022X.2021.1948429 (Source: Renal Failure)
Source: Renal Failure - July 8, 2021 Category: Urology & Nephrology Authors: Zhengying Fang Chenni Gao Yikai Cai Lin Lu Haijin Yu Hafiz Muhammad Jafar Hussain Zijin Chen Chuanlei Li Wenjie Wei Yuhan Huang Xiang Li Shuwen Yu Yinhong Ji Qinjie Weng Yan Ouyang Xiaofan Hu Jun Tong Jian Liu Mingyu Liu Xiaoman Xu Yixin Zha Zhiyin Ye Tin Source Type: research

Peritoneal transport status and first episode of peritonitis: a large cohort study
This study aimed to explore the relationship between peritoneal transport status and the first episode of peritonitis, as well as the prognosis of patients undergoing continuous ambulatory peritoneal dialysis (CAPD).METHOD: A retrospective cohort study was conducted, analyzing data of CAPD patients from 1st January 2009, to 31st December 2017. Baseline data within 3 months after PD catheter placement was recorded. Cox multivariate regression analysis was performed to determine the risk factors for the first episode of peritonitis, technique failure and overall mortality.RESULTS: A total of 591 patients were included in our...
Source: Renal Failure - July 8, 2021 Category: Urology & Nephrology Authors: Jing Hu Hao Zhang Bin Yi Source Type: research

Predialysis predictors for identifying patients requiring dialysis at a higher glomerular filtration rate
CONCLUSIONS: For patients with heart failure, low serum albumin level, high BUN/Cr ratio, or hyperuricemia, clinicians can provide predialysis counseling in advance and consider early creation of vascular access.PMID:34219598 | DOI:10.1080/0886022X.2021.1940202 (Source: Renal Failure)
Source: Renal Failure - July 5, 2021 Category: Urology & Nephrology Authors: Junseok Jeon Hye Ryoun Jang Wooseong Huh Yoon-Goo Kim Dae Joong Kim Jung Eun Lee Source Type: research

Dominant factors of the phosphorus regulatory network differ under various dietary phosphate loads in healthy individuals
CONCLUSIONS: Variations in dietary phosphorus intake led to changes in the central factors involved in phosphorus metabolism.PMID:34193019 | DOI:10.1080/0886022X.2021.1945463 (Source: Renal Failure)
Source: Renal Failure - July 1, 2021 Category: Urology & Nephrology Authors: Guoxin Ye Jiaying Zhang Zhaori Bi Weichen Zhang Minmin Zhang Qian Zhang Mengjing Wang Jing Chen Source Type: research

Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway
In this study, a mouse model of sepsis-induced AKI, generated by cecal ligation and puncture operation, was used to investigate the protective effects of THC and the role of SIRT1. Histological manifestation and TUNEL analysis were observed to determine the severity of kidney damage. Levels of BUN, SCr, KIM-1, and UAlb/Cr were calculated to assess the renal function. Expressions of IL-1β, IL-6, and TNF-α were measured to evaluate the inflammatory response. MDA content, SOD, GSH, CAT, and GPx activities and DHE staining were analyzed to estimate the degree of oxidative stress. Protein expressions of SIRT1, Ac-p65...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Lu Li Xiaoxi Liu Shasha Li Qingyan Wang Hongru Wang Menglu Xu Yanxin An Source Type: research

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery
In this study, we applied a composite index of neutrophil-lymphocyte * platelet ratio (NLPR), and explore the significance of the dynamics of perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI).METHODS: During July 1st and December 31th 2019, participants were prospectively derived from the 'Zhongshan Cardiovascular Surgery Cohort'. NLPR was determined using neutrophil counts, lymphocyte and platelet count at the two-time points. Dose-response relationship analyses were applied to delineate the non-linear odds ratio (OR) of CSA-AKI in different NLPR levels. Then NLPRs were integrated i...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Yang Li Zhouping Zou Yunlu Zhang Bowen Zhu Yichun Ning Bo Shen Chunsheng Wang Zhe Luo Jiarui Xu Xiaoqiang Ding Source Type: research

Different kidney function trajectory patterns before dialysis in elderly patients: clinical implications and outcomes
Conclusions. There are different patterns of eGFR trajectories before dialysis initiation in the elderly, that may help to identify those who are more likely to experience an accelerated decline in kidney function, with impact on pre ESKD care and in the mortality risk after dialysis.PMID:34187290 | DOI:10.1080/0886022X.2021.1945464 (Source: Renal Failure)
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Josefina Santos Pedro Oliveira Milton Severo Lu ísa Lobato Ant ónio Cabrita Isabel Fonseca Source Type: research

Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy
Ren Fail. 2021 Dec;43(1):1063-1075. doi: 10.1080/0886022X.2021.1944875.ABSTRACTIt is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-ap...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Xueling Xu Huifang Wang Dandan Guo Xiaofei Man Jun Liu Junying Li Congjuan Luo Ming Zhang Li Zhen Xuemei Liu Source Type: research

Is it safe to receive kidneys from deceased kidney donors tested positive for covid-19 infection?
Ren Fail. 2021 Dec;43(1):1060-1062. doi: 10.1080/0886022X.2021.1931319.NO ABSTRACTPMID:34187293 | DOI:10.1080/0886022X.2021.1931319 (Source: Renal Failure)
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Hatem Ali Mahmoud Mohamed Miklos Z Molnar Nithya Krishnan Source Type: research

Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients
CONCLUSION: Urinary L-FABP variation at 6 h after admission was significantly associated with 14-day mortality.PMID:34187294 | DOI:10.1080/0886022X.2021.1943439 (Source: Renal Failure)
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Ginga Suzuki Ryo Ichibayashi Saki Yamamoto Hibiki Serizawa Yoshimi Nakamichi Masayuki Watanabe Mitsuru Honda Source Type: research

Prognosis of severe drug-induced acute interstitial nephritis requiring renal replacement therapy
Ren Fail. 2021 Dec;43(1):1020-1027. doi: 10.1080/0886022X.2021.1942914.ABSTRACTOBJECTIVE: Drug-induced acute interstitial nephritis (DAIN) is often associated with improved outcomes, whereas some patients may still progress to chronic kidney disease (CKD). The aim of this study was to evaluate the prognosis of patients with severe DAIN requiring renal replacement therapy (RRT) at baseline, and to explore the risk factors of progression to CKD.METHODS: We performed a retrospective study of patients with severe DAIN confirmed by renal biopsies in our center over a 10 years period, all the patients received RRT at presentatio...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Li Huang Shaoshan Liang Jianhua Dong Wenjing Fan Caihong Zeng Ti Zhang Shuiqin Cheng Yongchun Ge Source Type: research

Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway
In this study, a mouse model of sepsis-induced AKI, generated by cecal ligation and puncture operation, was used to investigate the protective effects of THC and the role of SIRT1. Histological manifestation and TUNEL analysis were observed to determine the severity of kidney damage. Levels of BUN, SCr, KIM-1, and UAlb/Cr were calculated to assess the renal function. Expressions of IL-1β, IL-6, and TNF-α were measured to evaluate the inflammatory response. MDA content, SOD, GSH, CAT, and GPx activities and DHE staining were analyzed to estimate the degree of oxidative stress. Protein expressions of SIRT1, Ac-p65...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Lu Li Xiaoxi Liu Shasha Li Qingyan Wang Hongru Wang Menglu Xu Yanxin An Source Type: research

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery
In this study, we applied a composite index of neutrophil-lymphocyte * platelet ratio (NLPR), and explore the significance of the dynamics of perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI).METHODS: During July 1st and December 31th 2019, participants were prospectively derived from the 'Zhongshan Cardiovascular Surgery Cohort'. NLPR was determined using neutrophil counts, lymphocyte and platelet count at the two-time points. Dose-response relationship analyses were applied to delineate the non-linear odds ratio (OR) of CSA-AKI in different NLPR levels. Then NLPRs were integrated i...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Yang Li Zhouping Zou Yunlu Zhang Bowen Zhu Yichun Ning Bo Shen Chunsheng Wang Zhe Luo Jiarui Xu Xiaoqiang Ding Source Type: research

Different kidney function trajectory patterns before dialysis in elderly patients: clinical implications and outcomes
Conclusions. There are different patterns of eGFR trajectories before dialysis initiation in the elderly, that may help to identify those who are more likely to experience an accelerated decline in kidney function, with impact on pre ESKD care and in the mortality risk after dialysis.PMID:34187290 | DOI:10.1080/0886022X.2021.1945464 (Source: Renal Failure)
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Josefina Santos Pedro Oliveira Milton Severo Lu ísa Lobato Ant ónio Cabrita Isabel Fonseca Source Type: research

Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy
Ren Fail. 2021 Dec;43(1):1063-1075. doi: 10.1080/0886022X.2021.1944875.ABSTRACTIt is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-ap...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Xueling Xu Huifang Wang Dandan Guo Xiaofei Man Jun Liu Junying Li Congjuan Luo Ming Zhang Li Zhen Xuemei Liu Source Type: research

Is it safe to receive kidneys from deceased kidney donors tested positive for covid-19 infection?
Ren Fail. 2021 Dec;43(1):1060-1062. doi: 10.1080/0886022X.2021.1931319.NO ABSTRACTPMID:34187293 | DOI:10.1080/0886022X.2021.1931319 (Source: Renal Failure)
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Hatem Ali Mahmoud Mohamed Miklos Z Molnar Nithya Krishnan Source Type: research

Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients
CONCLUSION: Urinary L-FABP variation at 6 h after admission was significantly associated with 14-day mortality.PMID:34187294 | DOI:10.1080/0886022X.2021.1943439 (Source: Renal Failure)
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Ginga Suzuki Ryo Ichibayashi Saki Yamamoto Hibiki Serizawa Yoshimi Nakamichi Masayuki Watanabe Mitsuru Honda Source Type: research

Prognosis of severe drug-induced acute interstitial nephritis requiring renal replacement therapy
Ren Fail. 2021 Dec;43(1):1020-1027. doi: 10.1080/0886022X.2021.1942914.ABSTRACTOBJECTIVE: Drug-induced acute interstitial nephritis (DAIN) is often associated with improved outcomes, whereas some patients may still progress to chronic kidney disease (CKD). The aim of this study was to evaluate the prognosis of patients with severe DAIN requiring renal replacement therapy (RRT) at baseline, and to explore the risk factors of progression to CKD.METHODS: We performed a retrospective study of patients with severe DAIN confirmed by renal biopsies in our center over a 10 years period, all the patients received RRT at presentatio...
Source: Renal Failure - June 30, 2021 Category: Urology & Nephrology Authors: Li Huang Shaoshan Liang Jianhua Dong Wenjing Fan Caihong Zeng Ti Zhang Shuiqin Cheng Yongchun Ge Source Type: research

ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040 (Source: Renal Failure)
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research

Peritoneal dialysis-related peritonitis caused by gram-negative organisms: ten-years experience in a single center
Ren Fail. 2021 Dec;43(1):993-1003. doi: 10.1080/0886022X.2021.1939050.ABSTRACTOBJECTIVES: Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference for clinical diagnosis, treatment and prevention.METHODS: A retrospective analysis was performed examining patients who developed peritoneal dialysis-related peritonitis (PDRP) from 1 January 2009 to 31 December 2018.RESULTS: Among 898 PD patients, 677 episodes of peritonitis occurred in 344 patients. Over 10 years, the proportion of gram-negative bacterial peritonitis increased from 0% to 26.15% (p = .045). E. co...
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Ying Zeng Linsen Jiang Ying Lu Zhi Wang Kai Song Huaying Shen Sheng Feng Source Type: research

Untargeted serum metabolomics and tryptophan metabolism profiling in type 2 diabetic patients with diabetic glomerulopathy
Ren Fail. 2021 Dec;43(1):980-992. doi: 10.1080/0886022X.2021.1937219.ABSTRACTDiabetic glomerulopathy (DG) remains the prevalent microvascular complication and leading cause of shortened lifespan in type-2 diabetes mellitus (T2DM) despite improvement in hyperglycemia control. Considering the pivotal role of kidney in metabolism, using untargeted metabolomic techniques to globally delineate the serum metabolite profiles will help advance understanding pathogenetic underpinnings of renal biopsy-confirmed DG from the perspective of metabolism specifically. Fourteen pathologically diagnosed DG patients secondary to T2DM and 14 ...
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Fanliang Zhang Ruixue Guo Wen Cui Li Wang Jing Xiao Jin Shang Zhanzheng Zhao Source Type: research

Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome
Ren Fail. 2021 Dec;43(1):1004-1011. doi: 10.1080/0886022X.2021.1942913.ABSTRACTBACKGROUND AND OBJECTIVES: The impact of acute kidney injury (AKI) on the progression of renal function in idiopathic membranous nephropathy (iMN) with nephrotic syndrome (NS) patients have not yet been reported, we sought to investigate the incidence, clinical features and prognosis of AKI in iMN with NS patients and determine clinical predictors for progression from AKI to advanced chronic kidney disease (CKD) stage.METHODS: We analyzed clinical and pathological data of iMN with NS patients retrospectively collected from Jan 2012 to Dec 2018. ...
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Tianxin Chen Ying Zhou Xinxin Chen Bo Chen Jingye Pan Source Type: research

ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040 (Source: Renal Failure)
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research

Peritoneal dialysis-related peritonitis caused by gram-negative organisms: ten-years experience in a single center
Ren Fail. 2021 Dec;43(1):993-1003. doi: 10.1080/0886022X.2021.1939050.ABSTRACTOBJECTIVES: Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference for clinical diagnosis, treatment and prevention.METHODS: A retrospective analysis was performed examining patients who developed peritoneal dialysis-related peritonitis (PDRP) from 1 January 2009 to 31 December 2018.RESULTS: Among 898 PD patients, 677 episodes of peritonitis occurred in 344 patients. Over 10 years, the proportion of gram-negative bacterial peritonitis increased from 0% to 26.15% (p = .045). E. co...
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Ying Zeng Linsen Jiang Ying Lu Zhi Wang Kai Song Huaying Shen Sheng Feng Source Type: research

Untargeted serum metabolomics and tryptophan metabolism profiling in type 2 diabetic patients with diabetic glomerulopathy
Ren Fail. 2021 Dec;43(1):980-992. doi: 10.1080/0886022X.2021.1937219.ABSTRACTDiabetic glomerulopathy (DG) remains the prevalent microvascular complication and leading cause of shortened lifespan in type-2 diabetes mellitus (T2DM) despite improvement in hyperglycemia control. Considering the pivotal role of kidney in metabolism, using untargeted metabolomic techniques to globally delineate the serum metabolite profiles will help advance understanding pathogenetic underpinnings of renal biopsy-confirmed DG from the perspective of metabolism specifically. Fourteen pathologically diagnosed DG patients secondary to T2DM and 14 ...
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Fanliang Zhang Ruixue Guo Wen Cui Li Wang Jing Xiao Jin Shang Zhanzheng Zhao Source Type: research

Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome
Ren Fail. 2021 Dec;43(1):1004-1011. doi: 10.1080/0886022X.2021.1942913.ABSTRACTBACKGROUND AND OBJECTIVES: The impact of acute kidney injury (AKI) on the progression of renal function in idiopathic membranous nephropathy (iMN) with nephrotic syndrome (NS) patients have not yet been reported, we sought to investigate the incidence, clinical features and prognosis of AKI in iMN with NS patients and determine clinical predictors for progression from AKI to advanced chronic kidney disease (CKD) stage.METHODS: We analyzed clinical and pathological data of iMN with NS patients retrospectively collected from Jan 2012 to Dec 2018. ...
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Tianxin Chen Ying Zhou Xinxin Chen Bo Chen Jingye Pan Source Type: research

ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040 (Source: Renal Failure)
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research