The furosemide stress test: current use and future potential
Ren Fail. 2021 Dec;43(1):830-839. doi: 10.1080/0886022X.2021.1906701.ABSTRACTLoop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating pulmonary edema. The naturetic response to a loop diuretic is based on its unique renal pharmacology. Our review article summarizes the pharmacology of furosemide in the intact nephron and discusses how this response might be altered b...
Source: Renal Failure - May 11, 2021 Category: Urology & Nephrology Authors: Blaithin A McMahon Lakhmir S Chawla Source Type: research

Extracellular water/total body water ratio as predictor of mortality in hemodialysis patients
CONCLUSIONS: The post-dialysis ECW/TBW ratio measured by BIS can be a predictor of all-cause and cardiovascular mortality.PMID:33966595 | DOI:10.1080/0886022X.2021.1922442 (Source: Renal Failure)
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: Rosa P érez-Morales Javier Donate-Correa Ernesto Mart ín-Núñez Nayra P érez-Delgado Carla Ferri Aurora L ópez-Montes Alejandro Jim énez-Sosa Juan Francisco Navarro-Gonz ález Source Type: research

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation
Ren Fail. 2021 Dec;43(1):803-810. doi: 10.1080/0886022X.2021.1915801.ABSTRACTHypoxia-induced inflammation is the critical pathological feature of acute kidney injury (AKI). Activation of hypoxia-inducible factor (HIF) signaling is considered as a central mechanism of body adapting to hypoxia. Hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 (Roxadustat) is a first-in-class HIF stabilizer for the treatment of patients with renal anemia. The current study aimed to investigate whether FG-4592 could protect against ischemia/reperfusion (I/R)-induced kidney injury via inhibiting inflammation. Here, efficacy of FG-4...
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: A-Feng Miao Jian-Xiang Liang Lei Yao Jun-Ling Han Li-Juan Zhou Source Type: research

Effects of intensive blood pressure control on mortality and cardiorenal function in chronic kidney disease patients
Ren Fail. 2021 Dec;43(1):811-820. doi: 10.1080/0886022X.2021.1920427.ABSTRACTBACKGROUND: Blood pressure (BP) variability is highly correlated with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). However, appropriate BP targets in patients with CKD remain uncertain.METHODS: We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials (RCTs) of CKD patients who underwent intensive BP management. Kappa score was used to assess inter-rater agreement. A good agreement between the authors was observed to inter-rater reliability of RCTs selection (kappa = 0.77; P = 0.005)...
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: Yong Zhang Jing-Jing Li An-Jun Wang Bo Wang Shou-Liang Hu Heng Zhang Tian Li Yan-Hong Tuo Source Type: research

Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study
Ren Fail. 2021 Dec;43(1):851-859. doi: 10.1080/0886022X.2021.1923527.ABSTRACTPURPOSE: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.METHODS: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group, n = 5923) and at least 60 years (elderly group, n = 1199). The clinical and pathological characteristics of renal biopsy patients in th...
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: Ping Nie Yan Lou Yali Wang Xue Bai Li Zhang Shan Jiang Bing Li Ping Luo Source Type: research

Extracellular water/total body water ratio as predictor of mortality in hemodialysis patients
CONCLUSIONS: The post-dialysis ECW/TBW ratio measured by BIS can be a predictor of all-cause and cardiovascular mortality.PMID:33966595 | DOI:10.1080/0886022X.2021.1922442 (Source: Renal Failure)
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: Rosa P érez-Morales Javier Donate-Correa Ernesto Mart ín-Núñez Nayra P érez-Delgado Carla Ferri Aurora L ópez-Montes Alejandro Jim énez-Sosa Juan Francisco Navarro-Gonz ález Source Type: research

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation
Ren Fail. 2021 Dec;43(1):803-810. doi: 10.1080/0886022X.2021.1915801.ABSTRACTHypoxia-induced inflammation is the critical pathological feature of acute kidney injury (AKI). Activation of hypoxia-inducible factor (HIF) signaling is considered as a central mechanism of body adapting to hypoxia. Hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 (Roxadustat) is a first-in-class HIF stabilizer for the treatment of patients with renal anemia. The current study aimed to investigate whether FG-4592 could protect against ischemia/reperfusion (I/R)-induced kidney injury via inhibiting inflammation. Here, efficacy of FG-4...
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: A-Feng Miao Jian-Xiang Liang Lei Yao Jun-Ling Han Li-Juan Zhou Source Type: research

Effects of intensive blood pressure control on mortality and cardiorenal function in chronic kidney disease patients
Ren Fail. 2021 Dec;43(1):811-820. doi: 10.1080/0886022X.2021.1920427.ABSTRACTBACKGROUND: Blood pressure (BP) variability is highly correlated with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). However, appropriate BP targets in patients with CKD remain uncertain.METHODS: We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials (RCTs) of CKD patients who underwent intensive BP management. Kappa score was used to assess inter-rater agreement. A good agreement between the authors was observed to inter-rater reliability of RCTs selection (kappa = 0.77; P = 0.005)...
Source: Renal Failure - May 10, 2021 Category: Urology & Nephrology Authors: Yong Zhang Jing-Jing Li An-Jun Wang Bo Wang Shou-Liang Hu Heng Zhang Tian Li Yan-Hong Tuo Source Type: research

Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease
CONCLUSION: These finding demonstrate that in addition to older and higher SBP, a high serum IS level is a significant biomarker associated with AS in patients with CKD.PMID:33941031 | DOI:10.1080/0886022X.2021.1921797 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Sheng-Chao Wang Yu-Hsien Lai Chin-Hung Liu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Source Type: research

The 100 top-cited articles in diabetic kidney disease: a bibliometric analysis
CONCLUSIONS: This bibliometric analysis helps in identifying the milestones, inadequacies, classic hotspots, and emerging trends of DKD. Pathogenesis and treatment are core themes in DKD research, while high-quality articles on the prediction and biomarker are insufficient. New analyzing metrics are needed to assess the actual impact of these top-cited articles on clinical practice.PMID:33941037 | DOI:10.1080/0886022X.2021.1919528 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Zineng Huang Huifang Zhang Ying Luo Cong Wei Yuee Zhao Ying Huang Lei Zhang Wei Chen Liyu He Hong Liu Lin Sun Fuyou Liu Li Xiao Source Type: research

Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease
CONCLUSION: These finding demonstrate that in addition to older and higher SBP, a high serum IS level is a significant biomarker associated with AS in patients with CKD.PMID:33941031 | DOI:10.1080/0886022X.2021.1921797 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Sheng-Chao Wang Yu-Hsien Lai Chin-Hung Liu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Source Type: research

The 100 top-cited articles in diabetic kidney disease: a bibliometric analysis
CONCLUSIONS: This bibliometric analysis helps in identifying the milestones, inadequacies, classic hotspots, and emerging trends of DKD. Pathogenesis and treatment are core themes in DKD research, while high-quality articles on the prediction and biomarker are insufficient. New analyzing metrics are needed to assess the actual impact of these top-cited articles on clinical practice.PMID:33941037 | DOI:10.1080/0886022X.2021.1919528 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Zineng Huang Huifang Zhang Ying Luo Cong Wei Yuee Zhao Ying Huang Lei Zhang Wei Chen Liyu He Hong Liu Lin Sun Fuyou Liu Li Xiao Source Type: research

Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease
CONCLUSION: These finding demonstrate that in addition to older and higher SBP, a high serum IS level is a significant biomarker associated with AS in patients with CKD.PMID:33941031 | DOI:10.1080/0886022X.2021.1921797 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Sheng-Chao Wang Yu-Hsien Lai Chin-Hung Liu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Source Type: research

The 100 top-cited articles in diabetic kidney disease: a bibliometric analysis
CONCLUSIONS: This bibliometric analysis helps in identifying the milestones, inadequacies, classic hotspots, and emerging trends of DKD. Pathogenesis and treatment are core themes in DKD research, while high-quality articles on the prediction and biomarker are insufficient. New analyzing metrics are needed to assess the actual impact of these top-cited articles on clinical practice.PMID:33941037 | DOI:10.1080/0886022X.2021.1919528 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Zineng Huang Huifang Zhang Ying Luo Cong Wei Yuee Zhao Ying Huang Lei Zhang Wei Chen Liyu He Hong Liu Lin Sun Fuyou Liu Li Xiao Source Type: research

Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease
CONCLUSION: These finding demonstrate that in addition to older and higher SBP, a high serum IS level is a significant biomarker associated with AS in patients with CKD.PMID:33941031 | DOI:10.1080/0886022X.2021.1921797 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Sheng-Chao Wang Yu-Hsien Lai Chin-Hung Liu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Source Type: research

The 100 top-cited articles in diabetic kidney disease: a bibliometric analysis
CONCLUSIONS: This bibliometric analysis helps in identifying the milestones, inadequacies, classic hotspots, and emerging trends of DKD. Pathogenesis and treatment are core themes in DKD research, while high-quality articles on the prediction and biomarker are insufficient. New analyzing metrics are needed to assess the actual impact of these top-cited articles on clinical practice.PMID:33941037 | DOI:10.1080/0886022X.2021.1919528 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Zineng Huang Huifang Zhang Ying Luo Cong Wei Yuee Zhao Ying Huang Lei Zhang Wei Chen Liyu He Hong Liu Lin Sun Fuyou Liu Li Xiao Source Type: research

Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease
CONCLUSION: These finding demonstrate that in addition to older and higher SBP, a high serum IS level is a significant biomarker associated with AS in patients with CKD.PMID:33941031 | DOI:10.1080/0886022X.2021.1921797 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Sheng-Chao Wang Yu-Hsien Lai Chin-Hung Liu Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Source Type: research

The 100 top-cited articles in diabetic kidney disease: a bibliometric analysis
CONCLUSIONS: This bibliometric analysis helps in identifying the milestones, inadequacies, classic hotspots, and emerging trends of DKD. Pathogenesis and treatment are core themes in DKD research, while high-quality articles on the prediction and biomarker are insufficient. New analyzing metrics are needed to assess the actual impact of these top-cited articles on clinical practice.PMID:33941037 | DOI:10.1080/0886022X.2021.1919528 (Source: Renal Failure)
Source: Renal Failure - May 4, 2021 Category: Urology & Nephrology Authors: Zineng Huang Huifang Zhang Ying Luo Cong Wei Yuee Zhao Ying Huang Lei Zhang Wei Chen Liyu He Hong Liu Lin Sun Fuyou Liu Li Xiao Source Type: research

Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: We found that statin use in patients with CKD may slow CKD progression by lowering urinary albumin and protein excretions or increasing creatinine clearance. Further large-scale RCTs should be conducted to evaluate the long-term effects of statins on renal outcomes. Abbreviations: CKD: chronic kidney disease; RCT: randomized controlled trials; WMD: weighted mean differences; CI: confidence intervals; ACEI: angiotensin-converting enzyme inhibitors; eGFR: estimated glomerular filtration rate.PMID:33926359 | DOI:10.1080/0886022X.2021.1915799 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Lin Zhao Shu Li Ying Gao Source Type: research

Reply to 'Is one-stage f-URS without prior stenting really safe for solitary kidney patients with 1-3  cm renal stones?'
Ren Fail. 2021 Dec;43(1):779-780. doi: 10.1080/0886022X.2021.1915333.NO ABSTRACTPMID:33928828 | DOI:10.1080/0886022X.2021.1915333 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Yang Pan Gang Chen Source Type: research

Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: We found that statin use in patients with CKD may slow CKD progression by lowering urinary albumin and protein excretions or increasing creatinine clearance. Further large-scale RCTs should be conducted to evaluate the long-term effects of statins on renal outcomes. Abbreviations: CKD: chronic kidney disease; RCT: randomized controlled trials; WMD: weighted mean differences; CI: confidence intervals; ACEI: angiotensin-converting enzyme inhibitors; eGFR: estimated glomerular filtration rate.PMID:33926359 | DOI:10.1080/0886022X.2021.1915799 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Lin Zhao Shu Li Ying Gao Source Type: research

Reply to 'Is one-stage f-URS without prior stenting really safe for solitary kidney patients with 1-3  cm renal stones?'
Ren Fail. 2021 Dec;43(1):779-780. doi: 10.1080/0886022X.2021.1915333.NO ABSTRACTPMID:33928828 | DOI:10.1080/0886022X.2021.1915333 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Yang Pan Gang Chen Source Type: research

Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: We found that statin use in patients with CKD may slow CKD progression by lowering urinary albumin and protein excretions or increasing creatinine clearance. Further large-scale RCTs should be conducted to evaluate the long-term effects of statins on renal outcomes. Abbreviations: CKD: chronic kidney disease; RCT: randomized controlled trials; WMD: weighted mean differences; CI: confidence intervals; ACEI: angiotensin-converting enzyme inhibitors; eGFR: estimated glomerular filtration rate.PMID:33926359 | DOI:10.1080/0886022X.2021.1915799 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Lin Zhao Shu Li Ying Gao Source Type: research

Reply to 'Is one-stage f-URS without prior stenting really safe for solitary kidney patients with 1-3  cm renal stones?'
Ren Fail. 2021 Dec;43(1):779-780. doi: 10.1080/0886022X.2021.1915333.NO ABSTRACTPMID:33928828 | DOI:10.1080/0886022X.2021.1915333 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Yang Pan Gang Chen Source Type: research

Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: We found that statin use in patients with CKD may slow CKD progression by lowering urinary albumin and protein excretions or increasing creatinine clearance. Further large-scale RCTs should be conducted to evaluate the long-term effects of statins on renal outcomes. Abbreviations: CKD: chronic kidney disease; RCT: randomized controlled trials; WMD: weighted mean differences; CI: confidence intervals; ACEI: angiotensin-converting enzyme inhibitors; eGFR: estimated glomerular filtration rate.PMID:33926359 | DOI:10.1080/0886022X.2021.1915799 (Source: Renal Failure)
Source: Renal Failure - April 30, 2021 Category: Urology & Nephrology Authors: Lin Zhao Shu Li Ying Gao Source Type: research

A pilot study of thiamin and folic acid in hemodialysis patients with cognitive impairment
This study aimed to explore the effectiveness of thiamin and folic acid supplementation on the improvement of the cognitive function in patients with maintenance hemodialysis.METHOD: In the present study, we randomly assigned patients undergoing hemodialysis who had the Montreal Cognitive Assessment (MoCA) score lower than 26 to treatment group (n = 25, thiamin 90 mg/day combined with folic acid 30 mg/day) or control group (n = 25, nonintervention). All subjects were followed up for 96 weeks. The primary outcome was the improvement of the MoCA score. The secondary outcomes included homocysteine level, survival and safety.R...
Source: Renal Failure - April 29, 2021 Category: Urology & Nephrology Authors: Renhua Lu Yan Fang Yijun Zhou Miaolin Che Jianxiao Shen Qian Liu Haifen Zhang Shuting Pan Yan Lin Qin Wang Shan Mou Zhaohui Ni Leyi Gu Source Type: research

Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis
Conclusions: Multiple factors could affect the risk of mortality in PD patients.PMID:33913381 | DOI:10.1080/0886022X.2021.1918558 (Source: Renal Failure)
Source: Renal Failure - April 29, 2021 Category: Urology & Nephrology Authors: Jialing Zhang Xiangxue Lu Han Li Shixiang Wang Source Type: research

Apo A1/Apo B ratio and acute coronary syndrome among peritoneal dialysis patients
Ren Fail. 2021 Dec;43(1):737-742. doi: 10.1080/0886022X.2021.1918556.ABSTRACTBACKGROUND: Acute coronary syndrome (ACS) is prevalent in continuous ambulatory peritoneal dialysis (CAPD) patients. However, the association between the apoprotein profile and ACS is not well known. Therefore, we aimed to investigate the relationship between apoproteins and ACS in CAPD patients.METHODS: Eighty-one CAPD patients were included in this retrospective study. The primary endpoint was ACS. Predictors were baseline apoprotein levels, particularly the ratio of apoprotein A1 (Apo A1)/apoprotein B (Apo B). Cox regression was used to determi...
Source: Renal Failure - April 29, 2021 Category: Urology & Nephrology Authors: Tianlei Chen Min Yang Source Type: research

Clinical outcomes, quality of life, and costs evaluation of peritoneal dialysis management models in Shanghai Songjiang District: a multi-center and prospective cohort study
Conclusions: Compared with conventional management, community-based FCH management achieved similar outcomes, improved psychological health, reduced medical budgets, and thus had a good social prospect.PMID:33913395 | DOI:10.1080/0886022X.2021.1918164 (Source: Renal Failure)
Source: Renal Failure - April 29, 2021 Category: Urology & Nephrology Authors: Xiaoyan Ma Min Tao Yan Hu Lunxian Tang Jiasun Lu Yingfeng Shi Hui Chen Si Chen Yi Wang Binbin Cui Lin Du Weiwei Liang Guansen Huang Xun Zhou Andong Qiu Shougang Zhuang Xiujuan Zang Na Liu Source Type: research

Anti-glomerular basement membrane disease mediated by IgG and IgA: a case report
CONCLUSIONS: This is the first case report of anti-GBM disease mediated by IgG and IgA. If the clinical presentation and histopathological findings are suggestive of atypical anti-GBM disease, alternative laboratory tests such as Western blotting analysis can be used to confirm the diagnosis.PMID:33913397 | DOI:10.1080/0886022X.2021.1914658 (Source: Renal Failure)
Source: Renal Failure - April 29, 2021 Category: Urology & Nephrology Authors: Guming Zou Haitao Lu Li Zhuo Wanzhong Zou Wenge Li Source Type: research

Retrospective analysis of < em > Tripterygium wilfordii < /em > polyglycoside combined with angiotensin receptor blockers for the treatment of primary membranous nephropathy with sub-nephrotic proteinuria
CONCLUSIONS: These data demonstrate that TWG may be a promising treatment for PMN patients with sub-nephrotic proteinuria, whether anti-PLA2R antibody is positive or negative.PMID:33904354 | DOI:10.1080/0886022X.2021.1918555 (Source: Renal Failure)
Source: Renal Failure - April 27, 2021 Category: Urology & Nephrology Authors: Yuanyuan Guo Ningning Guo Jin Wang Ruiqiang Wang Lin Tang Source Type: research

Correlation analysis between expression of histone deacetylase 6 and clinical parameters in IgA nephropathy patients
Ren Fail. 2021 Dec;43(1):684-697. doi: 10.1080/0886022X.2021.1914657.ABSTRACTBACKGROUND: It has been demonstrated that histone deacetylase 6 (HDAC6) is involved in various kidney diseases in experimental study. However, correlation between HDAC6 and clinical parameters in IgA nephropathy (IgAN) patients is still unknown.METHODS: A total of 46 human kidney biopsy specimens with IgAN were selected as observation group, specimens of normal renal cortex tissue that was not affected by the tumor from patients with renal carcinoma (n = 7) served as control. We investigated the relationship between HDAC6 and clinical parameters i...
Source: Renal Failure - April 26, 2021 Category: Urology & Nephrology Authors: Yan Hu Minghua Shang Yingfeng Shi Min Tao Weijie Yuan Lunxian Tang Xiaoyan Ma Binbin Cui Hui Chen Xun Zhou Shougang Zhuang Na Liu Source Type: research

Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study
This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR).METHODS: Australian Diabetes, Obesity and Lifestyle (AusDiab) study participants were asked to complete a birthweight questionnaire. The associations between birthweight and eGFR were determined.RESULTS: A total of 4502 reported information related to their birthweight, with the other responders did not provide a value. The birthweight of the participants ranged from 0.4 to 7.0 kg with a mean-(SD) of 3.37 (0.7) kg. The mean (95%CI) birthweight was lower for females, 3.28 (0.6) kg, when compared to males, 3.5 (0.7) kg. E...
Source: Renal Failure - April 26, 2021 Category: Urology & Nephrology Authors: Issa Al Salmi Suad Hannawi Source Type: research

Comparison of outcomes of peritoneal dialysis between patients after failed kidney transplant and transplant-na ïve patients: a meta-analysis of observational studies
CONCLUSION: Patients with kidney transplant failure initiating PD do not have an increased risk of mortality, technique failure, or peritonitis as compared to transplant-naïve patients initiating PD. Further studies are needed to evaluate the impact of prior and ongoing immunosuppression on PD outcomes.PMID:33896379 | DOI:10.1080/0886022X.2021.1914659 (Source: Renal Failure)
Source: Renal Failure - April 26, 2021 Category: Urology & Nephrology Authors: Xiaohua Meng Weifei Wu Shuang Xu Zhiqun Cheng Source Type: research

Self-reported snoring is associated with chronic kidney disease in obese but not in normal-weight Chinese adults
CONCLUSIONS: Snoring appears to be independently associated with CKD in obese but not in normal-weight Chinese adults.PMID:33896382 | DOI:10.1080/0886022X.2021.1915332 (Source: Renal Failure)
Source: Renal Failure - April 26, 2021 Category: Urology & Nephrology Authors: Ziyun Jiang Jun Qin Kai Liang Ruxing Zhao Fei Yan Xinguo Hou Chuan Wang Li Chen Source Type: research

MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone
Ren Fail. 2021 Dec;43(1):676-683. doi: 10.1080/0886022X.2021.1915800.ABSTRACTAIM: MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate levels of miRNA 21 and miRNA 155 in RH and their relationships with aldosterone.METHOD: Thirty-two normotensive patients, 30 newly diagnosed HT patients, and 20 RH patients were included in the stu...
Source: Renal Failure - April 23, 2021 Category: Urology & Nephrology Authors: Sonat P ınar Kara Gulsum Ozkan Ahsen Y ılmaz Nergiz Bayrak çı Sava ş Güzel Elif Geyik Source Type: research

Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells
CONCLUSION: Considering that TLR3 signaling is implicated, at least in part, in LN pathogenesis, our results suggest that anti-malarial agents exert a protective effect against the development of inflammation in GECs, as postulated in LN. Interestingly, CQ is a rather powerful inhibitor compared with HCQ on TLR3 signaling-induced chemokine expression in GECs. In turn, these findings may further support the theory that the use of HCQ is safer than CQ in a clinical setting. However, further detailed studies are needed to confirm our preliminary findings.PMID:33820486 | PMC:PMC8032345 | DOI:10.1080/0886022X.2021.1908901 (Source: Renal Failure)
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Riko Sato Tadaatsu Imaizumi Tomomi Aizawa Shojiro Watanabe Koji Tsugawa Shogo Kawaguchi Kazuhiko Seya Tomoh Matsumiya Hiroshi Tanaka Source Type: research

All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats
In conclusion, low expression of Angpt-1 was associated with the RIF disease and ATRA treatment can increase the Angpt-1 and alleviate the RIF lesion in UUO rats.PMID:33820492 | PMC:PMC8032328 | DOI:10.1080/0886022X.2021.1910046 (Source: Renal Failure)
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Zhiqing Zhong Hong-Yan Li Hongzhen Zhong Wenshan Lin Shujun Lin Tianbiao Zhou Source Type: research

Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey
Ren Fail. 2021 Dec;43(1):651-657. doi: 10.1080/0886022X.2021.1910045.ABSTRACTBullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. The skin injury was likely to be a trigger of BP in all the three PD patients. Nifedipine and icodextrin exposures were possible factors directly or indirectly affecting the onset of BP, because they were common in the three ca...
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Kohkichi Morimoto Tadashi Yoshida Naoki Washida Kiyotaka Uchiyama Takashin Nakayama Hiroshi Itoh Mototsugu Oya Source Type: research

Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells
CONCLUSION: Considering that TLR3 signaling is implicated, at least in part, in LN pathogenesis, our results suggest that anti-malarial agents exert a protective effect against the development of inflammation in GECs, as postulated in LN. Interestingly, CQ is a rather powerful inhibitor compared with HCQ on TLR3 signaling-induced chemokine expression in GECs. In turn, these findings may further support the theory that the use of HCQ is safer than CQ in a clinical setting. However, further detailed studies are needed to confirm our preliminary findings.PMID:33820486 | PMC:PMC8032345 | DOI:10.1080/0886022X.2021.1908901 (Source: Renal Failure)
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Riko Sato Tadaatsu Imaizumi Tomomi Aizawa Shojiro Watanabe Koji Tsugawa Shogo Kawaguchi Kazuhiko Seya Tomoh Matsumiya Hiroshi Tanaka Source Type: research

All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats
In conclusion, low expression of Angpt-1 was associated with the RIF disease and ATRA treatment can increase the Angpt-1 and alleviate the RIF lesion in UUO rats.PMID:33820492 | PMC:PMC8032328 | DOI:10.1080/0886022X.2021.1910046 (Source: Renal Failure)
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Zhiqing Zhong Hong-Yan Li Hongzhen Zhong Wenshan Lin Shujun Lin Tianbiao Zhou Source Type: research

Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey
Ren Fail. 2021 Dec;43(1):651-657. doi: 10.1080/0886022X.2021.1910045.ABSTRACTBullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. The skin injury was likely to be a trigger of BP in all the three PD patients. Nifedipine and icodextrin exposures were possible factors directly or indirectly affecting the onset of BP, because they were common in the three ca...
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Kohkichi Morimoto Tadashi Yoshida Naoki Washida Kiyotaka Uchiyama Takashin Nakayama Hiroshi Itoh Mototsugu Oya Source Type: research

Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells
CONCLUSION: Considering that TLR3 signaling is implicated, at least in part, in LN pathogenesis, our results suggest that anti-malarial agents exert a protective effect against the development of inflammation in GECs, as postulated in LN. Interestingly, CQ is a rather powerful inhibitor compared with HCQ on TLR3 signaling-induced chemokine expression in GECs. In turn, these findings may further support the theory that the use of HCQ is safer than CQ in a clinical setting. However, further detailed studies are needed to confirm our preliminary findings.PMID:33820486 | DOI:10.1080/0886022X.2021.1908901 (Source: Renal Failure)
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Riko Sato Tadaatsu Imaizumi Tomomi Aizawa Shojiro Watanabe Koji Tsugawa Shogo Kawaguchi Kazuhiko Seya Tomoh Matsumiya Hiroshi Tanaka Source Type: research

All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats
In conclusion, low expression of Angpt-1 was associated with the RIF disease and ATRA treatment can increase the Angpt-1 and alleviate the RIF lesion in UUO rats.PMID:33820492 | DOI:10.1080/0886022X.2021.1910046 (Source: Renal Failure)
Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Zhiqing Zhong Hong-Yan Li Hongzhen Zhong Wenshan Lin Shujun Lin Tianbiao Zhou Source Type: research