Assessing the role of Chemokine (C-C motif) ligand 14 in AKI: a European consensus meeting
CONCLUSION: Real world urinary CCL14 use appears to provide improved care options to patients at risk for persistent severe AKI. Experts believe there is a role for CCL14 in AKI management and it may potentially reduce AKI-disease burden. There is, however, an urgent need for evidence on treatment decisions and adjustments based on CCL14 results.PMID:38666354 | DOI:10.1080/0886022X.2024.2345747 (Source: Renal Failure)
Source: Renal Failure - April 26, 2024 Category: Urology & Nephrology Authors: Jay L Koyner Christian Arndt Jaume Baldira Martinez de Irujo S ílvia Coelho Manuel Garcia-Montesinos de la Pe ña Luca di Girolamo Michael Joannidis Pablo Jorge-Monjas Christian Koch Steven Lobaz Alain Meyer Marlies Ostermann Nicoletta Pertica John R Pro Source Type: research
Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage-myofibroblast transition
This study aimed to investigate whether iguratimod could affect renal fibrosis progression. Three different concentrations of iguratimod (30 mg/kg/day, 10 mg/kg/day, and 3 mg/kg/day) were used to intervene in unilateral ureteral obstruction (UUO) model mice. Iguratimod at 10 mg/kg/day was observed to be effective in slowing UUO-mediated renal fibrosis. In addition, stimulating bone marrow-derived macrophages with IL-4 and/or iguratimod, or with TGF-β and iguratimod or SRC inhibitors in vitro, suggested that iguratimod mitigates the progression of renal fibrosis in UUO mice, at least in part, by inhibiting the IL-4/STAT6 s...
Source: Renal Failure - April 26, 2024 Category: Urology & Nephrology Authors: Yueyuan Zhou Zhilan Li Shenyi Yu Xuan Wang Tingting Xie Weiru Zhang Source Type: research
The prevalence of functional dyspepsia using Rome IV questionnaire among chronic kidney disease patients
Conclusion: The prevalence of FD amongst CKD patients is 14.7% with EPS the predominant subtype. Male patients, HCV patients, patients with higher CKD stages and highly impaired eGFR (low eGFR) are more probable to have FD.PMID:38655865 | PMC:PMC11044757 | DOI:10.1080/0886022X.2024.2344651 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: Omar Abdelazim Alshymaa A Hassnine Basma Fathy Ahmed Mgdy Nady Semeda Shereen R Mahmoud Zeinab M Saad Haitham A Mahmoud Source Type: research
Exploring alternatives to laparoscopic renal biopsy: a critical examination of safety, efficacy, and costs
Ren Fail. 2024 Dec;46(1):2343387. doi: 10.1080/0886022X.2024.2343387. Epub 2024 Apr 24.NO ABSTRACTPMID:38655869 | DOI:10.1080/0886022X.2024.2343387 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: David Fernando Torres Cortes Daniela Carrascal Gonzalo Andr és Montaño Rozo Jos é David Cardona Ortegón Oscar Mauricio Rivero Rapalino Source Type: research
Shenkang injection for the treatment of acute kidney injury: a systematic review and meta-analysis
CONCLUSION: The use of SKI in AKI patients may reduce SCr, BUN, CysC, 24-h Upro levels, and APACHE II scores in AKI patients. The incidence of adverse reactions did not differ from that in the control group. Additional rigorous clinical trials will be necessary in the future to thoroughly evaluate and establish the effectiveness of SKI in the treatment of AKI.PMID:38655870 | PMC:PMC11044765 | DOI:10.1080/0886022X.2024.2338566 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: Shengchun Liao Yurou Chen Shuting Wang Chen Wang Chaoyang Ye Source Type: research
Factors associated with post-hospitalization dialysis dependence in ECMO patients who required continuous renal replacement therapy
CONCLUSIONS: AKI requiring CRRT was associated with high mortality in patients receiving ECMO. Nonetheless, most ECMO survivors became dialysis-free before hospital discharge. Variables associated with the need for outpatient dialysis included hyperlipidemia and prolonged need for CRRT during hospitalization.PMID:38655876 | PMC:PMC11044754 | DOI:10.1080/0886022X.2024.2343810 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: Carlos Rodrigo Franco Palacios Rudiona Hoxhaj Catlyn Thigpen Jeffrey Jacob Source Type: research
The prevalence of functional dyspepsia using Rome IV questionnaire among chronic kidney disease patients
Conclusion: The prevalence of FD amongst CKD patients is 14.7% with EPS the predominant subtype. Male patients, HCV patients, patients with higher CKD stages and highly impaired eGFR (low eGFR) are more probable to have FD.PMID:38655865 | DOI:10.1080/0886022X.2024.2344651 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: Omar Abdelazim Alshymaa A Hassnine Basma Fathy Ahmed Mgdy Nady Semeda Shereen R Mahmoud Zeinab M Saad Haitham A Mahmoud Source Type: research
Exploring alternatives to laparoscopic renal biopsy: a critical examination of safety, efficacy, and costs
Ren Fail. 2024 Dec;46(1):2343387. doi: 10.1080/0886022X.2024.2343387. Epub 2024 Apr 24.NO ABSTRACTPMID:38655869 | DOI:10.1080/0886022X.2024.2343387 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: David Fernando Torres Cortes Daniela Carrascal Gonzalo Andr és Montaño Rozo Jos é David Cardona Ortegón Oscar Mauricio Rivero Rapalino Source Type: research
Shenkang injection for the treatment of acute kidney injury: a systematic review and meta-analysis
CONCLUSION: The use of SKI in AKI patients may reduce SCr, BUN, CysC, 24-h Upro levels, and APACHE II scores in AKI patients. The incidence of adverse reactions did not differ from that in the control group. Additional rigorous clinical trials will be necessary in the future to thoroughly evaluate and establish the effectiveness of SKI in the treatment of AKI.PMID:38655870 | DOI:10.1080/0886022X.2024.2338566 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: Shengchun Liao Yurou Chen Shuting Wang Chen Wang Chaoyang Ye Source Type: research
Factors associated with post-hospitalization dialysis dependence in ECMO patients who required continuous renal replacement therapy
CONCLUSIONS: AKI requiring CRRT was associated with high mortality in patients receiving ECMO. Nonetheless, most ECMO survivors became dialysis-free before hospital discharge. Variables associated with the need for outpatient dialysis included hyperlipidemia and prolonged need for CRRT during hospitalization.PMID:38655876 | DOI:10.1080/0886022X.2024.2343810 (Source: Renal Failure)
Source: Renal Failure - April 24, 2024 Category: Urology & Nephrology Authors: Carlos Rodrigo Franco Palacios Rudiona Hoxhaj Catlyn Thigpen Jeffrey Jacob Source Type: research
Complement activation in wasp venom-induced acute kidney injury
In this study, a complement-depleted mouse model was used to investigate the role of complement in wasp venom-induced AKI. Mice were randomly categorized into control, cobra venom factor (CVF), AKI, and CVF + AKI groups. Compared to the AKI group, the CVF + AKI group showed improved pathological changes in kidneys and reduced blood urea nitrogen (BUN) levels. The expression levels of renal complement 3 (C3), complement 5 (C5), complement 1q (C1q), factor B (FB), mannose-binding lectin (MBL), and C5b-9 in AKI group were upregulated compared with the control group. Conversely, the renal tissue expression levels of C3, C5, C1...
Source: Renal Failure - April 21, 2024 Category: Urology & Nephrology Authors: Rui Cheng Liang Xu Jianhua Gong Fanglin Yu Ying Lv Hai Yuan Fengqi Hu Source Type: research
Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study
CONCLUSION: HFR treatment effectively eliminates uremic toxins from the bloodstream of patients undergoing MHD, especially protein-bound toxins and large middle-molecule toxins. Additionally, it retains essential physiological compounds like albumin and branched-chain amino acids, underscoring its commendable safety profile.PMID:38632963 | PMC:PMC11028005 | DOI:10.1080/0886022X.2024.2338929 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Renhua Lu Yan Fang Wangshu Wu Xiaojun Zeng Tingting Liu Yue Qian Yuanyuan Xie Yijun Zhou Leyi Gu Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | PMC:PMC11028022 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study
CONCLUSIONS: High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. ΔNLR might be utilized to facilitate risk stratification and optimize septic AKI management.PMID:38637281 | PMC:PMC11028010 | DOI:10.1080/0886022X.2024.2343818 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Wei Wei Caihong Liu Guojiao Song Letian Yang Jian Li Bo Wang Ting Yin Yingying Yang Liang Ma Ling Zhang Ping Fu Yuliang Zhao Source Type: research
