Greetings to the readers.
Authors: Fülöp T PMID: 30747027 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal structural image processing techniques: a systematic review.
CONCLUSIONS: A medical image analysis method should provide an auto-adaptive and no external-human action dependency. In addition, since medical systems should have special characteristics such as high accuracy and reliability then clinical validation is highly recommended. New high-quality studies based on Moore neighborhood contour tracking method for glomeruli segmentation and using powerful texture analysis techniques such as the local binary pattern are recommended. PMID: 30747036 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 14, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis.
Authors: Jang HN, Park HJ, Cho HS, Bae E, Lee TW, Chang SH, Park DJ Abstract Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the prognosis. We used LODS score to predict prognosis of AKA. We retrospectively reviewed the medical records of 46 patients who were diagnosed as AKA in our hospital. The mean LODS score was 6.3. The probability of mortality based on the LODS score was...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease - a randomized double blind crossover study.
CONCLUSIONS: Statin may have a small but potentially beneficial effect on serum hepcidin, which may lead to improvement of anemia control in CKD patients. PMID: 30741616 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hemoglobin targets for the anemia in patients with dialysis-dependent chronic kidney disease: a meta-analysis of randomized, controlled trials.
This article aims to establish the suitable hemoglobin in order to provide clinical guidance. METHODS: MEDLINE, EmBase, the Cochrane Library and other databases were searched with both MeSH terms and keywords to gather randomized controlled trials that assessed all-cause mortality, cardiovascular events, fistula thrombosis, infectious diseases and transfusion among dialysis-dependent patients using erythropoiesis-stimulating agents. The meta-analysis was accomplished via Revman 5.3 version. FINDINGS: Totally, nine eligible studies were included, with study subjects involving 3228 patients. There was a significantly...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats.
Authors: Zhang J, Tang L, Li GS, Wang J Abstract The present study aimed to explore the protective mechanism of curcumin-precondition in renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided into Sham, IRI, and Curcumin groups (n = 10). The model of IRI was induced by clamping the left renal artery for 45 min followed by 24 h reperfusion with the contralateral nephrectomy. ELISA was used to examine the expression of Cr, BUN, IL-8, TNF-α, and IL-6 in the serum; RT-PCR was used to detect the mRNA level of IL-8,TNF-α, and IL-6 in the kidney; ...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The incidence, risk factors, and clinical outcomes of acute kidney injury (staged using the RIFLE classification) associated with intravenous acyclovir administration.
Authors: Lee EJ, Jang HN, Cho HS, Bae E, Lee TW, Chang SH, Park DJ Abstract Intravenous (IV) acyclovir is commonly administered medication for viral infection but is well known for its nephrotoxicity. However, there was no study for incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV acyclovir administration. We retrospectively reviewed the medical records of 287 patients who were medicated IV acyclovir from January 2008 to May 2013 in Gyeongsang National University Hospital. All had documented medical histories and underwent medical review. Demographic data, risk factors,...
Source: Renal Failure - February 13, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The cartonectin levels at different stages of chronic kidney disease and related factors.
Authors: Yavuz YC, Altınkaynak K, Sevinc C, Ozbek Sebin S, Baydar I Abstract INTRODUCTION: Cartonectin was defined as a new adipokine released from rat and human adipocyte tissues, which is also known as CORS 26 or CTRP3 protein. Although there are several studies investigating the effects of cartonectin with obesity, anti-inflammatory mechanisms, and cardioprotective effects, there is no study about the effects of cartonectin in patients with chronic kidney disease yet. We aimed to investigate cartonectin levels in predialysis and dialysis patient groups, in other words, at different stages of chronic kidney dise...
Source: Renal Failure - February 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Review of the efficacy of AST-120 (KREMEZIN ®) on renal function in chronic kidney disease patients.
Review of the efficacy of AST-120 (KREMEZIN®) on renal function in chronic kidney disease patients. Ren Fail. 2019 Nov;41(1):47-56 Authors: Asai M, Kumakura S, Kikuchi M Abstract AST-120 (KREMEZIN®) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces. Uremic toxins such as indoxyl sulfate and p-cresyl sulfate are abundant in the blood of chronic kidney disease (CKD) patients and are related to the progression of both CKD and cardiovascular disease. AST-120 was approved in Japan i...
Source: Renal Failure - February 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats.
Authors: Lee TW, Bae E, Kim JH, Jang HN, Cho HS, Chang SH, Park DJ Abstract The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intragastrically injected for control group. ABGE was intragastrically injected for garlic group. Ten mg/kg of colistin was intraperitoneally injected for 6 consecutive days for colistin group. One percent of ABGE was done 30&thinsp...
Source: Renal Failure - February 6, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Authors: Hou J, Ding J, Li L, Peng Y, Gao X, Guo Z Abstract Sirtuin 1 (SIRT1), an NAD+-dependent deacylase, has been identified to be associated with renal tubular inflammatory conditions and metabolic disorders, which are risk factors of nephrolithiasis. To further confirm the role of the SIRT1 in kidney stone formation, the expression of SIRT1 was analyzed based on a mouse model and the genetic polymorphisms of SIRT1 gene was compared between patients with kidney stones and controls. The calcium oxalate (CaOx) crystal-induced renal injury model was established to analyzed the expression of SIRT1 in the kidney tis...
Source: Renal Failure - February 6, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of prophylactic antibiotics before peritoneal dialysis catheter implantation on the clinical outcomes of peritoneal dialysis patients.
CONCLUSIONS: Our study does not show any beneficial effect of antibiotic prophylaxis in reducing the postoperative peritonitis. PMID: 30706749 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 3, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study.
CONCLUSIONS: Our results mostly showed a new trend that the diagnosis of IgA nephropathy was not increasing and the prevalence of membranous nephropathy had increased, becoming the second most common type of primary glomerulonephritis. Key POINTS Distinguished with other domestic studies, IgA nephropathy did not show a trend of continuous growth although it still had about the half proportion of PGN, whereas membranous nephropathy kept rising and became the second common PGN. Concerning SGN, LN peaked in the younger-age and middle-age groups with a significant female prevalence, DN, BANS and SV had a male predominance peak...
Source: Renal Failure - December 1, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors analysis for hyperuricemic nephropathy among CKD stages 3-4 patients: an epidemiological study of hyperuricemia in CKD stages 3-4 patients in Ningbo, China.
CONCLUSIONS: These results showed SUA and other characteristics contributed to HN morbidity in CKD 3-4 patients. PMID: 30489209 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - December 1, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis.
CONCLUSIONS: This is the first study showing a comprehensive pathological description of the chronic features of the murine NTN model and that inhibiting the RAS pathway show a significant effect on functional and morphological parameters. PMID: 30403908 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 9, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Wider intraoperative glycemic fluctuation increases risk of acute kidney injury after pediatric cardiac surgery.
Authors: Hu GH, Duan L, Jiang M, Zhang CL, Duan YY Abstract OBJECTIVE: The association between poor intraoperative glycemic control and postoperative acute kidney injury (AKI) in adult cardiac surgery has been observed, but data in the pediatrics remain unknown. We performed a hypothesis that intraoperative hyperglycemia and/or wider glycemic fluctuation were associated with the incidence of postoperative AKI in pediatric cardiac surgery. METHODS: A retrospective study was performed in pediatrics who underwent cardiac surgery from 2013 to 2016. Perioperative glycemic data up to 48 hours after surgery wer...
Source: Renal Failure - November 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Reducing the occurrence rate of catheter dysfunction in peritoneal dialysis: a single-center experience about CQI.
Authors: Hu J, Liu Z, Liu J, Zhang H Abstract To reduce the occurrence rate of peritoneal dialysis (PD) catheter dysfunction caused by catheter displacement or plugging, this study screened all patients with peritoneal dialysis catheterization from 2002 to 2015 from the Third Xiangya Hospital of Central South University. There were 256 patients before continuous quality improvement (CQI) (from 2002 to 2007) and 813 patients after CQI (from 2008 to 2015). The occurrence rate of catheter dysfunction was 5.9% in the preCQI group: seven cases were associated with peritonitis, six cases were involved in omentum wrapping...
Source: Renal Failure - November 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Impact of acute kidney injury in donors on renal graft survival: a systematic review and Meta-Analysis.
Authors: Zheng YT, Chen CB, Yuan XP, Wang CX Abstract The acute kidney injury (AKI) of deceased donors was an important strategy to address donor shortage. This meta-analysis was conducted to explore the clinical effect of kidney transplantation from donors with AKI. PubMed, Embase, and Cochrane Library were searched through July 2017. Fourteen cohort studies, involving a total of 15,345 donors, were included. Studies were pooled, and the hazard ratio (HR), relative risk (RR), weighted mean difference (WMD), and their corresponding 95% confidence interval (CI) were calculated. The present meta-analysis showed no si...
Source: Renal Failure - November 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Vegetarian diet may ameliorate uremic pruritus in hemodialysis patients.
Authors: Tseng CY, Wu TT, Lai CW, Lin HJ, Chou CY, Chang CT, Chen HC Abstract OBJECTIVES: Systemic inflammation has been reported to be associated with uremic pruritus (UP). Although a vegetarian diet can reduce systemic inflammation in hemodialysis patients, the effect of vegetarian diet on UP is not clear. The purpose of the study was to know the possible effects of vegetarian diet on UP. METHODS: A cross-sectional study was done to compare the severity of UP and blood levels of systemic inflammatory markers between vegetarian and non-vegetarian hemodialysis patients. Six non-vegetarian patients with uremic p...
Source: Renal Failure - November 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective potential of Angelica sinensis polysaccharide extract against ethylene glycol-induced calcium oxalate urolithiasis.
Authors: Wang S, Li X, Bao J, Chen S Abstract PURPOSE: To evaluate a Angelica sinensis polysaccharide aqueous extract as a preventive agent in experimentally induced urolithiasis using in- vitro and vivo models. MATERIAL AND METHODS: Angelica sinensis polysaccharide was investigated in vitro to determine its antilithiatic effects on the formation and morphology of calcium oxalate (CaOx) crystals and was analyzed in vivo to determine its ability to prevent CaOx urolithiasis in rats subjected to ethylene glycol-induced urolithiasis. Potassium citrate administration was used in the positive control group. The urol...
Source: Renal Failure - November 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Significance of M2 macrophage in tubulointerstitial disease secondary to primary Sjogren's disease.
CONCLUSION: M2 macrophages are involved in acute tubular injury in patients with primary Sjogren's disease. Early intervention can improve renal function of tubulointerstitial injury secondary to primary Sjogren's disease. PMID: 30396309 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Baicalein protects renal tubular epithelial cells againsthypoxia-reoxygenation injury.
Authors: Chen C, Cai C, Lin H, Zhang W, Peng Y, Wu K Abstract BACKGROUND: To investigate the protective effects and mechanism of baicalein (BAI), a naturally occurring flavonoid, against hypoxia-reoxygenation (HR) injury in renal tubular epithelial cells (HK-2). METHODS: Cultured human renal proximal tubular cell line HK-2 was exposed to 24 h of hypoxia (5% CO2, 1% O2, and 94% N2), followed by 12 h of reoxygenation (5% CO2, 21% O2, and 74% N2). HK-2 cells were divided into three groups: control, HR, and HR-BAI (0.3 µg/ml). Reactive oxygen species (ROS) were measured and cell apoptosis...
Source: Renal Failure - November 4, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of environmental factors on clinical pathological changes of patients with immunoglobulin A nephropathy from different areas of China.
CONCLUSION: It was found that differential environment, life habits and patterns in the two investigated areas obviously may influence the variable characteristics of IgAN patients. PMID: 30373437 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 1, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The association between the red cell distribution width and diabetic nephropathy in patients with type-2 diabetes mellitus.
Authors: Zhang J, Zhang R, Wang Y, Li H, Han Q, Wu Y, Wang S, Guo R, Wang T, Li L, Liu F Abstract BACKGROUND: Red cell distribution width (RDW) has been reported to be involved in metabolic syndrome and cardiovascular events. Patients with diabetic nephropathy (DN) are often found to be with high level of RDW. The aim of this study was to explore whether RDW was associated with DN severity and progression in patients with type-2 diabetes mellitus (T2DM). METHODS: A total of 175 T2DM patients with biopsy-proven DN were enrolled. The baseline clinical and pathologic data of these patients was extracted from the m...
Source: Renal Failure - October 30, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Decreased expression of transforming growth factor- β1 and α-smooth muscle actin contributes to the protection of lotensin against chronic renal failure in rats.
CONCLUSIONS: Lotensin protects against advanced chronic kidney disease in rats with 5/6 Nx through the downregulation of TGF-β1 and α-SMA. PMID: 30371125 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 30, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis.
Authors: Stefanidis I, Tziastoudi M, Tsironi EE, Dardiotis E, Tachmitzi SV, Fotiadou A, Pissas G, Kytoudis K, Sounidaki M, Ampatzis G, Mertens PR, Liakopoulos V, Eleftheriadis T, Hadjigeorgiou GM, Santos M, Zintzaras E Abstract An association study was conducted to investigate the relation between 14 variants of glucose transporter 1 gene (SLC2A1) and the risk of type 2 diabetes (T2DM) leading to nephropathy. We also performed a meta-analysis of 11 studies investigating association between diabetic nephropathy (DN) and SLC2A1 variants. The cohort included 197 cases (T2DM with nephropathy), 155 diseased controls (T2...
Source: Renal Failure - October 26, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Peritoneal dialysis in Sichuan province of China - report from the Chinese National Renal Data System.
CONCLUSION: Our results, representing the first largest report of peritoneal dialysis in the Southwest of China, indicated increasing numbers of patients receiving peritoneal dialysis, which will require need for medical resource. PMID: 30343613 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 23, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Proteomics investigation of the changes in serum proteins after high- and low-flux hemodialysis.
CONCLUSIONS: Serum protein levels differentially changed after high- and low-flux HD. Long-term effects should be observed in future studies. PMID: 30284957 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 6, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum NGAL and FGF23 may have certain value in early diagnosis of CIN.
CONCLUSIONS: NGAL and FGF23 may have certain value in early diagnosis of CIN. PMID: 30278796 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical and pathologic characteristics of pauci-immune anti-myeloperoxidase antibody associated glomerulonephritis with nephrotic range proteinuria.
CONCLUSIONS: Pauci-immune ANCA GN with nephrotic proteinuria do not have more severe hypoalbuminemia, hypercoagulability or hyperlipidemia than patients without nephrotic proteinuria. Non-selective proteinuria might be the reason. However, pauci-immune ANCA GN with nephrotic proteinuria have more prevalent crescentic category in histopathology, higher incidence of AKI, gross hematuria and poorer renal prognosis despite of good sensitivity to therapy of proteinuria. PMID: 30278797 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil.
Authors: Brito DJA, Dos Santos EM, Dias RSC, Calado IL, Silva GEB, Lages JS, Monteiro Júnior FDC, Dos Santos AM, Salgado Filho N Abstract Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine ...
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Which is the most powerful adverse factor for autogenous access patency between diabetes and high arterial calcification burden?
Authors: Georgiadis GS, Argyriou C, Kantartzi K, Georgakarakos EI PMID: 30278807 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between MPO-463G   >  A polymorphism and chronic kidney disease: a meta-analysis.
CONCLUSIONS: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed. PMID: 30278820 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro.
CONCLUSIONS: ApI pretreatment can protect renal function against I/R injury and prevent renal tubular cells from apoptosis in vivo and in vitro which might through PI3K/Akt mediated mitochondria-dependent apoptosis signaling pathway. PMID: 30278824 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease.
CONCLUSIONS: Hemodialysis procedure contributes to inflammation and oxidative stress. PMID: 30277113 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
CONCLUSION: The expression of MALAT1 is increased in renal ischemia-reperfusion injury. It is likely that MALAT1 inhibits the hypoxia-induced inflammatory response through the NF-κB pathway. PMID: 30277425 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical and genetic analysis of distal renal tubular acidosis in three Chinese children.
CONCLUSIONS: We report the clinical and molecular characteristics of dRTA patients from China. The four novel mutations detected in our study extend the spectrum of gene mutations associated with primary dRTA. Furthermore, our study confirms the effect of early treatment in improving growth for dRTA patient and provides insight into the effects of rhGH on dRTA patients who were diagnosed late and exhibiting a persistent growth delay despite appropriate therapy. PMID: 30230413 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 20, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway.
In this study, we planned to clarify the mechanism of mTOR regulation of podocyte autophagy and the effect of rapamycin (RAPA). METHODS: All rats were randomly divided into normal control group (n = 8), DN group (n = 8), and RAPA group (n = 8). Blood and urine samples were collected at the 4th, 8th, and 12th weeks of the experiment. The serum creatinine (Scr), urine volume levels, and the 24 h urine protein (UP) levels were examined. The nephrin, podocin, mTOR, ribosomal S6 kinase 1 (S6K1), and autophagy marker light chain 3 (LC3II) expression levels were evaluated by im...
Source: Renal Failure - September 13, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum phosphate level at initiation of dialysis is associated with all-cause mortality: a multicenter prospective cohort study.
Authors: Owaki A, Inaguma D, Aoyama I, Inaba S, Koide S, Ito E, Takahashi K, Hayashi H, Hasegawa M, Yuzawa Y, AICOPP group Abstract INTRODUCTION: As glomerular filtration rate (GFR) decreases, serum phosphate level increases. Previous reports indicated that serum phosphate level was associated with mortality in patients on dialysis. However, few reports have examined the association using dialysis initiation as the baseline period. METHODS: This was a multicenter prospective cohort analysis including 1492 patients. Patients were classified into four quartiles based on the serum phosphate level at dialysis initi...
Source: Renal Failure - August 30, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study.
This study investigated the antioxidant effects of whortleberry against cisplatin-induced nephrotoxicity in rats. MATERIAL AND METHODS: This study included 48 female Sprague-Dawley rats weighing 263.68 ± 8.29 g. The rats were divided into the following six groups, with eight rats in each group: control, ethanol control, whortleberry control, cisplatin control, 16 mg/kg cisplatin +100 mg/kg whortleberry, and 16 mg/kg cisplatin +200 mg/kg whortleberry groups. Biochemical analysis was performed by measuring total oxidant status and total antioxidant status, histopath...
Source: Renal Failure - August 23, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Low-intensity pulsed ultrasound in combination with SonoVue induces cytotoxicity of human renal glomerular endothelial cells via repression of the ERK1/2 signaling pathway.
CONCLUSIONS: LIPUS combined with SonoVue induces cytotoxicity of HRGECs via repression of the ERK1/2 signaling pathway. PMID: 30122107 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 22, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro.
This study aimed to explore the protective effects of DIM on renal fibrosis. Unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models were established. The models were then treated with DIM for the assessment of its anti-fibrotic effects and mechanisms. Results of HE and Masson staining showed that DIM reduced kidney injury and production of interstitial collagens fibrosis. CTS also inhibited expression of fibronectin, collagen-1 but retain E-cadherin in the UUO model. Furthermore, DIM suppressed local fibroblast activation, as ev...
Source: Renal Failure - August 14, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors for BK virus infection in living-donor renal transplant recipients: a single-center study from China.
Authors: Li P, Cheng D, Wen J, Xie K, Li X, Ni X, Ji S, Chen J Abstract OBJECTIVES: BK virus (BKV) infection has become one of the main complications in renal transplant recipients (RTRs) with the arrival of newer potent immunosuppressive agents. However, reports on the epidemiology of BKV infection and risk factors in Chinese population after renal transplantation are scarce. METHODS: From June 2015 to July 2016, living-donor renal transplant recipients (LDRTRs) who routinely received the quantitative BKV DNA testing of urine and plasma samples using quantitative real-time polymerase chain reaction (PCR) for t...
Source: Renal Failure - July 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urinary protein and renal prognosis in idiopathic membranous nephropathy: a multicenter retrospective cohort study in Japan.
Authors: Yamaguchi M, Ando M, Katsuno T, Tsuboi N, Maruyama S Abstract BACKGROUND: Several studies have revealed a relationship between proteinuria and renal prognosis in idiopathic membranous nephropathy (IMN). The benefit of achieving subnephrotic proteinuria (
Source: Renal Failure - July 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Safety and efficacy of retrograde intrarenal surgery for the treatment of renal stone in solitary kidney patients.
CONCLUSION: RIRS is a safe and effective procedure for the treatment of renal stones in patients with solitary kidneys. RIRS did not adversely affect renal function at either the short-term or the long-term follow-up. PMID: 30040518 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 25, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions.
Authors: Ceylan B, Ozansoy M, Kılıç Ü, Yozgat Y, Ercan Ç, Yıldız P, Aslan T Abstract OBJECTIVE: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. METHODS: Twenty-eight Wistar rats were divided into four groups comprised of control, colistin, NAC, and colistin-NAC co-treatment, respectively. Serum creatinine and urine N-acetyl-β-d-glucosaminidase (NAG) levels were measured at different time intervals. Histological changes, apoptosis, total oxidant and antioxidant status, a...
Source: Renal Failure - July 24, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Are there any new reliable markers to detect renal injury in obese children?
Authors: Bostan Gayret Ö, Taşdemir M, Erol M, Tekin Nacaroğlu H, Zengi O, Yiğit Ö Abstract AIM: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. METHODS: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were...
Source: Renal Failure - July 24, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diabetes decreases patency of tunneled catheters in hemodialysis patients after first effective thrombolysis with urokinase.
CONCLUSIONS: Patients with diabetes are at higher risk of recurrent catheter-related thrombosis and therefore may require more aggressive anticoagulation therapy for its prevention. PMID: 30010473 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations.
CONCLUSIONS: It should not be forgotten that one of the causes of systemic complaints linked to acute toxicity exposed to the OP compound of fenthion may be cellular injury to glomerular and tubular structures in the kidneys. PMID: 30012025 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant.
CONCLUSIONS: Our results demonstrated a correlation between the UGT1A9 1399 C > T polymorphism and MPA pharmacokinetics among renal transplant patients. Determination of UGT1A9 polymorphism may help to achieve target of MPA blood concentrations. PMID: 30012031 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research