Clinical characteristics of thrombospondin type-1 domain-containing 7A-associated membranous nephropathy.
Authors: Suzuki T, Han W, Watanabe S, Terashita M, Nakata M, Ichikawa D, Shirai S, Shibagaki Y PMID: 32935600 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 18, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical characteristics and outcome of hemodialysis patients with COVID-19: a large cohort study in a single Chinese center.
Authors: Zou R, Chen F, Chen D, Xu CL, Xiong F Abstract BACKGROUND: Novel coronavirus disease (COVID-19) is spreading rapidly, which poses great challenges to patients on maintenance hemodialysis. Here we report the clinical features of 66 hemodialysis patients with laboratory confirmed COVID-19 infection. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Retrospective, single-center case series of the 66 hemodialysis patients with confirmed COVID-19 from 1 January to 5 March 2020; the final date of follow-up was 25 March 2020. RESULTS: The clinical data were collected from 66 hemodialysis patients with conf...
Source: Renal Failure - September 15, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Sudden onset of nephrotic syndrome in an asymptomatic Fabry patient: a case report.
CONCLUSION: Sudden onset of nephrotic syndrome, although rare, may occur in FD, even as the primary renal manifestation, but this usually suggests additional renal disease. Immunosuppressive treatment should be considered in such FD patient companying with nephrotic syndrome. PMID: 32924720 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - September 15, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats.
CONCLUSION: miR-15a-5p may participate in the endothelial to mesenchymal transition of PF caused by PD through VEGF. PMID: 32909490 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 12, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between low serum prealbumin levels and carpal tunnel syndrome in maintenance hemodialysis patients.
In this study, we focused on the association between low serum prealbumin levels and carpal tunnel syndrome in maintenance hemodialysis (MHD) patients using low-flux dialysis reuse. MATERIALS AND METHODS: Serum prealbumin levels were assessed to determine the association between low serum prealbumin levels and CTS in 373 prevalent MHD patients (the mean age was 45 years old, hemodialysis duration was 46 months). The patients were divided into 2 groups: the CTS group with 44 patients and the non-CTS group with 329 patients. RESULTS: The prevalence of CTS was 11.8%. Serum prealbumin showed a good progno...
Source: Renal Failure - September 12, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical characteristics and risks of Chin às 2019 novel coronavirus patients with AKI: a systematic review and meta-analysis.
Clinical characteristics and risks of Chinàs 2019 novel coronavirus patients with AKI: a systematic review and meta-analysis. Ren Fail. 2020 Nov;42(1):926-931 Authors: Zhang Z, Zhang L, Zha D, Hu C, Wu X PMID: 32875936 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 4, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

IgG deposits in the mesangium and capillary loops predict poor renal outcome in patients with IgA nephropathy: a single-center retrospective study.
Authors: Peng S, Lu W, Jiang X, Xu X, Wu Y Abstract BACKGROUND: Glomerular IgG deposition in patients with IgA nephropathy (IgAN) has been shown to be associated with poor renal survival; however, most published studies to date are too small-scale and inconsistent to provide guidance for clinical practice. METHODS: Based on renal biopsy findings, 742 patients were divided into the following groups: (i) IgA deposition alone (IgA) vs IgA + IgG deposition (IgA + IgG) and (ii) IgG co-deposition confined to the mesangium vs mesangium + capillary loops (CLs). The clinicopatho...
Source: Renal Failure - September 2, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of hypoxia-inducible factor-prolyl hydroxylase inhibitors on anemia in patients with CKD: a meta-analysis of randomized controlled trials including 2804 patients.
Authors: Wang B, Yin Q, Han YC, Wu M, Li ZL, Tu Y, Zhou LT, Wei Q, Liu H, Tang RN, Cao JY, Lv LL, Liu BC Abstract Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are orally active first-in-class new generation drugs for renal anemia. This extensive meta-analysis of randomized controlled trials (RCTs) was designed to provide clear information on the efficacy and safety of HIF-PHIs on anemia in chronic kidney disease (CKD) patients. Searches included PubMed, Web of Science, Ovid MEDLINE, and Cochrane Library database up to October 2019. RCTs of patients with CKD comparing HIF-PHIs with erythropoiesi...
Source: Renal Failure - September 2, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Elevated expression of HDAC6 in clinical peritoneal dialysis patients and its pathogenic role on peritoneal angiogenesis.
In this study, we analyzed the expression of HDAC6 in the peritoneum from patients with non-PD and PD-related peritonitis and dialysis effluent from stable PD patients. Our study revealed that HDAC6 expressed highly in the peritoneum with peritonitis and co-stained with α-smooth muscle actin (α-SMA), a biomarker of the myofibroblast. And the level of HDAC6 in the dialysate increased with time and positively correlated with transforming growth factor-β1 (TGF-β1), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), and negatively with cancer antigen 125 (CA125). In vitro, blockading HDAC...
Source: Renal Failure - September 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Collapsing glomerulopathy in a patient of Indian descent in the setting of COVID-19.
Authors: Deshmukh S, Zhou XJ, Hiser W PMID: 32862747 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Impact of renal function on patients with acute coronary syndromes: 15,593 patient-years study.
Authors: Kuźma Ł, Małyszko J, Kurasz A, Niwińska MM, Zalewska-Adamiec M, Bachórzewska-Gajewska H, Dobrzycki S Abstract INTRODUCTION: Coexistence of chronic kidney disease (CKD) in the case of acute coronary syndromes (ACS) significantly worsens the outcomes. AIM: The aim of our study was to assess renal function impact on mortality among patients with ACS. MATERIALS AND METHODS: The study was based on records of 21,985 patients hospitalized in the Medical University of Bialystok in 2009-2015. Inclusion criteria were ACS. Exclusion criteria were: death within 24 h of admission, eGFR
Source: Renal Failure - September 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Relationship between serum uric acid and all-cause mortality in dialysis patients: like being in wonderland, disoriented.
Authors: Zhao Y, Zhang L, Fan J, Zhao Z, Song L PMID: 32847412 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Response to the letter to the editor by Dr. Tadashi Yoshida: "long noncoding RNAs: new players regulating vascular calcification?"
Response to the letter to the editor by Dr. Tadashi Yoshida: "long noncoding RNAs: new players regulating vascular calcification?" Ren Fail. 2020 11;42(1):865-866 Authors: Guo W, Liu W PMID: 32847455 [PubMed - indexed for MEDLINE] (Source: Renal Failure)
Source: Renal Failure - August 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prediction models for acute kidney injury in patients with gastrointestinal cancers: a real-world study based on Bayesian networks.
CONCLUSION: BNs model not only delineates the qualitative and quantitative relationship between AKI and its associated factors but shows the more robust generalizability in AKI prediction. PMID: 32838613 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 26, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Successful treatment of anti-EPO antibody associated refractory anemia with hypoxia-inducible factor prolyl hydroxylase inhibitor.
Authors: Zhang H, Huang Z, He L, Yuan F, Sun L, Liu F, Xiao L PMID: 32814474 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 22, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Could KIM-1 and NGAL levels predict acute kidney injury after paracentesis? - preliminary study.
CONCLUSION: Kidney injury markers, especially serum NGAL, may be useful for the early detection of AKI. However, further research is required to determine if biomarkers of kidney injury may help identify patients with cirrhosis who would most likely benefit from early AKI prevention and treatment. PMID: 32808849 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 20, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hypocomplementemia is associated with more severe renal disease and worse renal outcomes in patients with ANCA-associated vasculitis: a retrospective cohort study.
This study evaluated the value of serum and kidney deposited C3 in predicting renal outcomes in AAV. METHODS: This was a retrospective study of 47 patients with AAV, who were categorized according to their serum C3 levels as hypo- or normo-complementemic and to those with positive or negative kidney biopsy immunofluorescence (IF) for C3. Baseline characteristics as well as progression to end-stage renal disease (ESRD) between the 2 groups were compared. RESULTS: In total, 23% (11/47) were hypo-complementemic; these patients were older (74 vs. 65 years, p = 0.013), had higher creatinine levels (...
Source: Renal Failure - August 15, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Biomarker evidence for distal tubular damage but cortical sparing in hospitalized diabetic patients with acute kidney injury (AKI) while on SGLT2 inhibitors.
CONCLUSIONS: Increased urinary and serum NGAL indicates that ATI, principally affecting distal tubular segments, may develop in some of the patients hospitalized with an acute illness and AKI while on SGLT2i. It is suggested that intensified medullary hypoxia by SGLT2i might be detrimental in this injury. By contrast, concomitantly unaltered KIM-1 might reflect improved cortical oxygenation by SGLT2i, and may explain an overall reduced risk of AKI with SGLT1i in large series. The independent potential of SGLT2i to inflict medullary hypoxic damage should be explored further. PMID: 32787602 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 15, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum Sphingosine-1-phosphate level and peritonitis in peritoneal dialysis patients.
Authors: Bai Q, Guo HX, Su CY, Han QF, Wang T, Tang W Abstract BACKGROUND: Given the important role of Sphingosine-1-phosphate (S1P) in maintaining the hemostasis in intestinal barrier function and regulation of inflammation and immune, we hypothesize that S1P might be a biomarker to predict peritonitis in peritoneal dialysis (PD) patients. METHODS: In this case-control study, 78 stable, continuous ambulatory peritoneal dialysis patients were enrolled and followed for the episode of PD associated peritonitis. Patients were divided into two groups by whether or not they had peritonitis during follow-up: non-peri...
Source: Renal Failure - August 15, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Early diagnosis and successful treatment of cytomegalovirus peritonitis in children with primary nephrotic syndrome: case series and literature review.
We report four cases of primary nephrotic syndrome complicated with CMV peritonitis. Four cases all diagnosed by RT-PCR of ascites (659-455 000 copies/mL). We mainly discusses the diagnosis and treatment of CMV peritonitis without gut perforation. PMID: 32757688 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 13, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors and outcomes of prolonged recovery from delayed graft function after deceased kidney transplantation.
CONCLUSION: Decreased donor terminal eGFR is a risk factor for prolonged recovery from DGF after deceased kidney transplantation. Prolonged DGF recovery time is associated with reduced graft function at 1-year post-transplant, and poor transplant outcome. PMID: 32772773 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 13, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Proton pump inhibitors may hinder hypophosphatemic effect of lanthanum carbonate, but not of ferric citrate hydrate or sucroferric oxyhydroxide, in hemodialysis patients.
Authors: Minakuchi H, Yoshida T, Kaburagi N, Fujino T, Endo S, Takemitsu TY, Yamashita N, Itoh H, Oya M Abstract Because end-stage renal disease patients undergoing hemodialysis frequently take acid suppressants for the treatment or prevention of gastrointestinal diseases, it is important to clarify the drug-interactions between acid suppressants and phosphate binders on the control of serum phosphate levels. In the present study, we examined whether the phosphate-lowering effects of three phosphate binders, lanthanum carbonate (LC), ferric citrate hydrate (FCH), and sucroferric oxyhydroxide (SFOH), were affected b...
Source: Renal Failure - August 13, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Dialysis-specific factors and incident atrial fibrillation in hemodialysis patients.
Authors: Baek SD, Jeung S, Kang JY, Jeon KH Abstract BACKGROUND: Atrial fibrillation (AF) is common in end-stage renal disease patients. Besides the traditional risk factors, we aimed to find dialysis-specific factors for developing incident AF. METHODS: From March 2017 to August 2018, we retrospectively reviewed all outpatient-based prevalent hemodialysis patients in our artificial kidney room, and they were followed up until August 2019. Dialysate calcium concentration (3 versus 2.5 mEq/L), time length (4 versus 3.5 h), frequency (thrice weekly versus twice weekly), dialyzer size (effective surfac...
Source: Renal Failure - August 13, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of seasonal factors on the incidence of peritoneal dialysis-associated peritonitis.
Authors: Zeng Y, Jiang X, Feng S, Jiang L, Wang Z, Shen H, Jiang S Abstract OBJECTIVES: To investigate the effects of climatic variables on peritoneal dialysis-associated peritonitis (PDAP) among patients receiving PD, such as seasonal variations in temperature and humidity. METHODS: A retrospective analysis was performed on PD patients, from 1 January 2011, to 31 December 2019. We evaluated the influence of seasonal factors on peritonitis rates and outcomes. RESULTS: Over the 9-year study period, 667 peritonitis episodes occurred, in 401 PD patients. Diarrhea-associated peritonitis occurred more frequently...
Source: Renal Failure - August 13, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between serum alkaline phosphatase and renal outcome in patients with type 2 diabetes mellitus.
In conclusion, an elevated ALP level was independently associated with poor renal outcome in patients with type 2 diabetes mellitus and nephrotic-range proteinuria after multivariate adjustment. PMID: 32781868 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 13, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Asymmetric dimethylarginine compartmental behavior during high-flux hemodialysis.
CONCLUSION: This study suggests that ADMA may present a multicompartmental distribution that cannot be representatively reflected by the urea kinetics model. PMID: 32727241 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Factors associated with hepatitis C antibody seroconversion after transplantation of kidneys from hepatitis C infected donors to hepatitis C na ïve recipients.
CONCLUSIONS: HCV antibody should not be considered routine screening for presence of infection in previously HCV naïve kidney transplant recipients receiving kidneys from HCV-infected donors, as only a modest percentage have antibody despite active viremia. The assessment of HCV viral load should be routine in all transplant recipients receiving organs from public health service increased risk donors. PMID: 32729359 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - August 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Monocyte counts are negatively associated with ankle-brachial index values in non-dialysis-dependent chronic kidney disease patients.
Authors: Kim MS, Oh DJ Abstract Our aim was to determine which leukocyte subtypes are most relevant to ankle-brachial index (ABI) values in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD). The study included 79 NDD-CKD patients aged 62.84 ± 12.09 years (63.33% men; 26.67% patients with diabetes) and 21 age-matched normal controls. According to the estimated glomerular filtration rate (eGFR) calculated by the CKD-Epidemiology Collaboration equation (CKD-EPI), we classified the study population into 2 groups (21 subjects with NDD-CKD with an eGFR 60-89 mL/min/1...
Source: Renal Failure - July 30, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

When the COVID-19 pandemic changed the follow-up landscape of chronic kidney disease: a survey of real-world nephrology practice.
Authors: Chen G, Zhou Y, Xia J, Yao J, Zheng K, Qin Y, Li X Abstract BACKGROUND: Patients with chronic kidney disease (CKD) require specialized management. However, the current situation of CKD management is unclear during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the influence of the COVID-19 on kidney patients' follow-ups. METHODS: In April 2020, we included patients who underwent kidney biopsy from January 2017 to December 2019 in a referral center of China, and then initiated a survey via telephone on different aspects of follow-up during the COVID-19 pandemic. We collected a...
Source: Renal Failure - July 30, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Regional citrate anticoagulation versus low molecular weight heparin anticoagulation for continuous venovenous hemofiltration in patients with severe hypercalcemia: a retrospective cohort study.
CONCLUSIONS: In patients with severe hypercalcemia who underwent CVVH, RCA more effectively decreased calcium levels and had a superior filter lifespan and no obvious adverse events compared with LMWH. Further prospective, randomized, controlled studies are warranted to obtain robust evidence. PMID: 32718221 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 30, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High uric acid or low uric acid which is better for hemodialysis patients?
Authors: Wang W, Liu W, Zhao Z, Zhao Y, Zhao C PMID: 32722978 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - July 30, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study.
CONCLUSIONS: Compared with the reported general population, the HD patients are susceptible to COVID-19 infection, especially older men and those with other underlying diseases. Moreover, HD patients have more severe infection and inflammation with less symptoms and worse outcome. COVID-19 infection can cause dialysis patients lower immunity, stronger inflammation, malnutrition, and internal environment disorder. Neutrophils/lymphocytes ratio does not reflect the severity of the HD patients with COVID-19. PMID: 32722980 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - July 30, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of prognosis and nephrotoxicity in patients treated with colistin in intensive care unit.
Authors: Gunay E, Kaya S, Baysal B, Yuksel E, Arac E Abstract INTRODUCTION: Nephrotoxicity is the most important adverse effect of colistin therapy. We investigated the frequency of nephrotoxicity, risk factors related to nephrotoxicity, and its relationship with mortality in patients who received intravenous colistin in intensive care units (ICUs). MATERIALS AND METHODS: We retrospectively reviewed the data of patients who received intravenous colistin in ICUs between 2011 and 2017. Acute kidney injury (AKI) diagnosis and staging were made based on the Kidney Disease Improving Global Outcome criteria. RESU...
Source: Renal Failure - July 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum elabela and apelin levels during different stages of chronic kidney disease.
Authors: Lu X, Liu S, Luan R, Cui W, Chen Y, Zhang Y, Lu Y, Zhang H, Shi L, Miao L, Xu F Abstract PURPOSE: The association of serum elabela (ELA) and apelin with the progression of chronic kidney disease (CKD) is unknown. We determined if serum ELA and apelin levels were associated with CKD stage. METHODS: This observational study involved 60 CKD patients and 20 healthy, age-, race-, and gender-matched controls. The participants were grouped according to renal function as follows: normal control group, CKD1 group (stage-1 CKD, 20 patients), CKD3 group (stage-3 CKD, 20 patients), and CKD5 group (stage-5 CKD, 20 ...
Source: Renal Failure - July 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

COVID-19: a novel menace for the practice of nephrology and how to manage it with minor devastation?
Authors: Ulu S, Gungor O, Gok Oguz E, Hasbal NB, Turgut D, Arici M Abstract Coronavirus disease 19 (COVID-19) became a nightmare for the world since December 2019. Although the disease affects people at any age; elderly patients and those with comorbidities were more affected. Everyday nephrologists see patients with hypertension, chronic kidney disease, maintenance dialysis treatment or kidney transplant who are also high-risk groups for the COVID-19. Beyond that, COVID-19 or severe acute respiratory syndrome (SARS) due to infection may directly affect kidney functions. This broad spectrum of COVID-19 influence on...
Source: Renal Failure - July 29, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Role of promoting inflammation of Kr üppel-like factor 6 in acute kidney injury.
CONCLUSION: These results suggest that (1) KLF6 might be a novel biomarker for early diagnosis of AKI and (2) KLF6 may play a role in promoting inflammation in AKI. PMID: 32698645 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 24, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Peritoneal dialysis outcomes in patients with nephrotic syndrome: a propensity score-matched cohort study.
CONCLUSIONS: Our study indicates that PD may be considered as a long-term renal replacement therapy for patients with ESRD and baseline NS. PMID: 32686569 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 22, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Outcomes of primary membranous nephropathy based on serum anti-phospholipase A2 receptor antibodies and glomerular phospholipase A2 receptor antigen status: a retrospective cohort study.
This study examined the prognosis of patients with PMN according to their serum anti-PLA2R antibody (SAb) and glomerular PLA2R antigen (GAg) status. METHODS: Patients diagnosed with PMN were included retrospectively. Patients were grouped according to their PLA2R status into the SAb-/GAg-, SAb-/GAg+, and SAb+/GAg + groups. Baseline data, renal biopsy results, treatment, and clinical data were compared among the groups. Cox univariable and multivariable analyses examined the factors related to complete remission (CR). RESULTS: A total of 114 patients were enrolled; 10 (9%) in the SAb-/GAg-, 23 (20%) in...
Source: Renal Failure - July 19, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

SOFA score is superior to APACHE-II score in predicting the prognosis of critically ill patients with acute kidney injury undergoing continuous renal replacement therapy.
CONCLUSIONS: The SOFA score showed a higher accuracy of mortality prediction in critically ill patients with AKI undergoing CRRT than the APACHE-II score. PMID: 32660294 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Glomerular C4 deposition and glomerulosclerosis predict worse renal outcomes in Chinese patients with IgA nephropathy.
Authors: Yang Y, Tang X, Yang Y, Li X, Li L, Huang K, Li Y, Li J, Fu P Abstract BACKGROUND: Immunoglobulin A nephropathy (IgAN) is a clinical and pathological syndrome with heterogenous manifestation and progression. Complement activation is involved in the disease. However, the clinical significance of C4 deposition in IgAN is obscure. METHODS: A multicenter retrospective study was conducted in biopsy-proven IgAN patients. Based on mesangial C4 deposition, patients were divided into two groups. The baseline clinical data and immunopathological phenotypes were compared. The composite endpoint was defined as eGF...
Source: Renal Failure - July 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Emerging medical therapies in crush syndrome - progress report from basic sciences and potential future avenues.
Authors: Li N, Wang X, Wang P, Fan H, Hou S, Gong Y Abstract Crush injury is a disease that is commonly found in victims of earthquakes, debris flows, mine disasters, explosions, terrorist attacks, local wars, and other accidents. The complications that arise due to the crush injury inflicted on victims give rise to crush syndrome (CS). If not treated in time, the mortality rate of CS is very high. The most important measure that can be taken to reduce mortality in such situations is to immediately start treatment. However, the traditional treatment methods such as fluid resuscitation, diuresis, and hemodialysis ar...
Source: Renal Failure - July 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Extreme hyperuricemia is a risk factor for infection-related deaths in incident dialysis patients: a multicenter prospective cohort study.
Authors: Yoshida H, Inaguma D, Koshi-Ito E, Ogata S, Kitagawa A, Takahashi K, Koide S, Hayashi H, Hasegawa M, Yuzawa Y, Tsuboi N Abstract INTRODUCTION: There are few studies on the association between serum uric acid (UA) level and mortality in incident dialysis patients. We aimed to clarify whether the serum UA level at dialysis initiation is associated with mortality during maintenance dialysis. METHODS: We enrolled 1486 incident dialysis patients who participated in a previous multicenter prospective cohort study in Japan. We classified the patients into the following five groups according to their serum UA ...
Source: Renal Failure - July 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Does rabbit anti-thymocyte globulin dose and antiviral prophylaxis alter the risk of the development of PTLD in renal transplant population?
Authors: Mohamed M, Ghonim MA, Abouzeid MM, Salas MAP PMID: 32662315 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 16, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Inquiry into the short- and long-term effects of Roux-en-Y gastric bypass on the glomerular filtration rate.
Authors: Friedman AN, Considine RV, Quinney SK Abstract Bariatric surgery is known to attenuate glomerular hyperfiltration over the long term and thereby protect the kidney from mechanical damage. Whether this effect is directly related to weight loss or is independent of weight as are some of its other beneficial metabolic effects is not known. We explored this question in a preliminary study that directly measured glomerular filtration rate (GFR) before, immediately after, and again many months after Roux-en-Y gastric bypass after large weight loss had occurred. We simultaneously measured stimulated circulat...
Source: Renal Failure - July 14, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Thrombolytic therapy for haemodialysis catheter dysfunction - value for money?
Authors: Yaxley J, Kurtkoti J, Stockwell L PMID: 32635778 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 10, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Red blood cell distribution width and peritoneal dialysis-associated peritonitis prognosis.
Conclusions: A Higher baseline level of RDW was significantly associated with a greater rate of treatment failure among PDAP episodes independent of other potential predictors. PMID: 32611209 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 4, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Nomenclature for kidney function and disease: executive summary and glossary from a Kidney Disease: Improving Global Outcomes (KDIGO) consensus conference.
Authors: Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Cheung M, Jadoul M, Winkelmayer WC PMID: 32619132 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - July 4, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The impact of switching to mTOR inhibitor-based immunosuppression on long-term non-melanoma skin cancer incidence and renal function in kidney and liver transplant recipients.
Conclusions: In this study, the conversion of maintenance immunosuppression from calcineurin inhibitors to mTOR inhibitors for clinical indications did appear to reduce the incidence of NMSC in kidney and liver transplant recipients. PMID: 32605413 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 3, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Shear wave elastography findings in Immunoglobulin A Nephropathy patients: is it more specific and sensitive for interstitial fibrosis or interstitial fibrosis/tubular atrophy?
Conclusions: YM which measured SWE is highly specific and sensitive in the diagnosis of IF, but not for IFTA in IgAN patients. Therefore, progression for IF in IgAN may be followed by SWE. PMID: 32597278 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 2, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum C-reactive protein to albumin ratio and mortality associated with peritoneal dialysis.
Conclusions: In patients undergoing PD, an increase in serum CAR is independently associated with increased risk for all-cause mortality. PMID: 32602387 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 2, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research