Diabetes decreases patency of tunneled catheters in hemodialysis patients after first effective thrombolysis with urokinase.
CONCLUSIONS: Patients with diabetes are at higher risk of recurrent catheter-related thrombosis and therefore may require more aggressive anticoagulation therapy for its prevention. PMID: 30010473 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations.
CONCLUSIONS: It should not be forgotten that one of the causes of systemic complaints linked to acute toxicity exposed to the OP compound of fenthion may be cellular injury to glomerular and tubular structures in the kidneys. PMID: 30012025 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant.
CONCLUSIONS: Our results demonstrated a correlation between the UGT1A9 1399 C > T polymorphism and MPA pharmacokinetics among renal transplant patients. Determination of UGT1A9 polymorphism may help to achieve target of MPA blood concentrations. PMID: 30012031 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy.
Authors: Cho AY, Yoon HJ, Lee KY, Sun IO Abstract OBJECTIVE: The aim of this study was to investigate the clinical characteristics of sepsis-induced acute kidney injury (AKI) in patients undergoing continuous renal replacement therapy (CRRT). METHODS: From 2011 to 2015, we enrolled 340 patients who were treated with CRRT for sepsis at the Presbyterian Medical Center. In all patients, CRRT was performed using the PRISMA platform. We divided these patients into two groups (survivors and non-survivors) according to the 28-day all-cause mortality. We compared clinical characteristics and analyzed the predictors of ...
Source: Renal Failure - July 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A meta-analysis of the association between diabetic patients and AVF failure in dialysis.
Authors: Yan Y, Ye D, Yang L, Ye W, Zhan D, Zhang L, Xiao J, Zeng Y, Chen Q Abstract PURPOSE: The most preferable vascular access for patients with end-stage renal failure needing hemodialysis is native arteriovenous fistula (AVF) on account of its access longevity, patient morbidity, hospitalization costs, lower risks of infection and fewer incidence of thrombotic complications. Meanwhile, according to National Kidney Foundation (NKF)̸Dialysis Out-comes Quality Initiative (DOQI) guidelines, AVF is more used than before. However, a significant percentage of AVF fails to support dialysis therapy due to lack of adeq...
Source: Renal Failure - May 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of combination sildenafil and gemfibrozil on cisplatin-induced nephrotoxicity; role of heme oxygenase-1.
CONCLUSIONS: Combination of sildenafil and gemfibrozil can be used in treatment of cisplatin-induced nephrotoxicity. HO-1 is a promising target for prevention and/or treatment of cisplatin-induced nephrotoxicity. PMID: 29707997 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 2, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy.
This study was determined to explore the effect of acteoside on mesangial injury underlying Th22 cell disorder in IgA nephropathy. Serum Th22 cells and urine total protein of patients with IgA nephropathy were measured before and after six months treatment of Rehmannia glutinosa acteoside or valsartan. Chemotactic assay and co-culture assay were performed to investigate the effect of acteoside on Th22 cell chemotaxis and differentiation. The expression of CCL20, CCL22 and CCL27 were analyzed. To explore the effect of acteoside on mesangial cell injury induced by inflammation, IL-1, IL-6, TNF-α and TGF-β1 were te...
Source: Renal Failure - May 2, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Detection of DKD stage 1 and treatment are essential.
Authors: Futrakul N, Futrakul P PMID: 29667906 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 19, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Management of staghorn renal stones.
Authors: Diri A, Diri B Abstract Staghorn stones are large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system. Although kidney stones are commoner in men, staghorn stones are less often reported in men compared to women and they are usually unilateral. Due to the significant morbidity and potential mortality attributed to staghorn stones, prompt assessment and treatment is mandatory. Conversely, conservative treatment has been shown to carry a mortality rate of 28% in 10-year period and 36% ris...
Source: Renal Failure - April 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Oxidative stress, NOx/l-arginine ratio and glutathione/glutathione S-transferase ratio as predictors of 'sterile inflammation' in patients with alcoholic cirrhosis and hepatorenal syndrome type II.
Authors: Nickovic VP, Miric D, Kisic B, Kocic H, Stojanovic M, Buttice S, Kocic G Abstract Continuous intake of alcohol leads to liver cirrhosis because of imbalance of oxidative stress/antioxidative defense and chronic 'sterile inflammation'. Hepatorenal syndrome (HRS) is the most severe complication of liver cirrhosis. The aim of our study was to assess: (1) the oxidative stress/antioxidative defense markers such as malondialdehyde (MDA), oxidative glutathione (GSH) and glutathione S-transferase (GST), (2) inflammation [C-reactive protein (CRP)], and (3) nitrate/nitrite levels (NOx) and its substrate L-arginine l...
Source: Renal Failure - April 18, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level.
CONCLUSION: We found that the G allele of chemerin rs17173608 compared to T allele decreased the risk of ESRD, and there was a significant association between chemerin and vaspin variants with plasma MDA level in a sample of the Iranian population. PMID: 29644922 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 15, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of the montreal cognitive assessment and the mini-mental state examination as screening tests in hemodialysis patients without symptoms.
We examined the cognitive function in hemodialysis (HD) patients and compared the Korean versions of the Montreal Cognitive Assessment (K-MoCA) and of the Mini-Mental State Examination (K-MMSE) to identify the better cognitive screening instrument in these patients. Thirty patients undergoing hemodialysis and 30 matched reference group of apparently healthy control were included. All subjects underwent the K-MoCA, K-MMSE and a neuropsychological test battery to measure attention, visuospatial function, language, memory and executive function. All cognitive data were converted to z-scores with appropriate age and education ...
Source: Renal Failure - April 12, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diabetic retinopathy may predict the renal outcomes of patients with diabetic nephropathy.
In this study, we aimed to clarify the relationship between DR and the progression of DN in patients with T2DM. METHODS: In the cross-section study, 250 patients with T2DM and biopsy-proven DN were divided into two groups: 130 in the DN without DR group (DN group) and 120 in the DN + DR group. Logistic regression analysis was performed to identify risk factors for DR. Of the above 250 patients, 141 were recruited in the cohort study who received follow-up for at least 1 year and the influence of DR on renal outcome was assessed using Cox regression. Renal outcome was defined as the progression to end-stag...
Source: Renal Failure - April 12, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A comprehensive analysis of Wnt/ β-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer.
In conclusion, As2O3 may have a significant effect on the Wnt/β-catenin signaling pathway for renal cancer treatment. The potential key DEGs are expected to be used as therapeutic targets. PMID: 29633893 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 12, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

An update on clinical significance of use of THSD7A in diagnosing idiopathic membranous nephropathy: a systematic review and meta-analysis of THSD7A in IMN.
CONCLUSIONS: The prevalence of THSD7A is more common in the PLA2R-negative patients than the IMN patients. Screening for malignancies in THSD7A-positive MN patients is recommended. PMID: 29623759 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 9, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Characteristics of patients with coexisting IgA nephropathy and membranous nephropathy.
Authors: Chen P, Shi SF, Qu Z, Zhao N, Xie XF, Lv JC, Liu LJ, Zhang H Abstract BACKGROUND: Coexistence of IgA nephropathy (IgAN) and membranous nephropathy (MN) in the same patient is rare. Few studies have reported the clinical and pathological features of patients with combined IgAN and MN (IgAN-MN). METHODS: The clinico-pathological features, levels of galactose-deficient IgA1 (Gd-IgA1) and autoantibodies against M-type transmembrane phospholipase A2 receptor (anti-PLA2R) in sera were compared among IgAN-MN, IgAN, and MN patients. RESULTS: Twenty-six patients with biopsy-proven IgAN-MN were enrolled. The...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin.
CONCLUSIONS: Our results demonstrated that ATRA could ameliorate glomerulosclerosis and proteinuria in GS, which may be related to suppressed expression of TRPC6. PMID: 29619864 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up.
In conclusion, KTR without previous vascular events have quite low cardiovascular/CVE rate within 1-year follow-up. VC evaluated as AoAC on pretransplant chest X-ray together with recipient eGFRdischarge could be related to kidney function in one-year follow-up. PMID: 29619867 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients.
Authors: Fayed A, El Nokeety MM, Heikal AA, Abdulazim DO, Naguib MM, Sharaf El Din UAA, Vascular Calcification Group (VCG) Abstract Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many pathologic sequences of CKD. The aim was to evaluate IR in pre-dialysis CKD patients looking for a possible association to mineral metabolism among CKD patients. A total of 100 stage 3-5 CKD patien...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Platelet indices and stroke.
Authors: Yildirim T, Akin F, Altun I, Yildirim SE, Basaran O, Soylu MO PMID: 29619869 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis.
Authors: Liu X, Zhai T, Ma R, Luo C, Wang H, Liu L Abstract OBJECTIVES: Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. METHODS: Pubmed, Embase, the Cochrane library, CBM were searched for randomized controlled trials (RCTs) that assessed the efficiency of lowering serum uric acid therapy on the progression of CKD without language restriction. Summary estimates o...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients.
CONCLUSIONS: Greater ARV was independently associated with increased risk of cardiovascular mortality in HD patients. Age and IDWG were independent related factors for ARV. PMID: 29619872 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of Gelofusine against cRGD-siRNA-induced nephrotoxicity in mice.
Authors: Liao W, Qin Y, Liao L, Cen B, Wu Z, Wei Y, Wang Z, Li G, Ji A Abstract Based on successful targeting to the αvβ3 integrin of cyclic arginine-glycine-aspartic acid (cRGD), cRGD-conjugated small interfering RNA (siRNA) exhibits tumor targeting and has become a new treatment strategy for solid tumors. However, the nephrotoxicity caused by its renal retention limits its clinical application. Here, we evaluated the protective effect of Gelofusine against cRGD-conjugated siRNA-induced nephrotoxicity in mice. Male Kunming mice (six per group) were either co-injected with Gelofusine and cRGD-siRNA or in...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Inhibitory effects of taraxasterol and aqueous extract of Taraxacum officinale on calcium oxalate crystallization: in vitro study.
Authors: Yousefi Ghale-Salimi M, Eidi M, Ghaemi N, Khavari-Nejad RA Abstract OBJECTIVE: We investigated and compared the effects of taraxasterol, aqueous extract of T. officinale (AET) aerial part, and potassium citrate (PC) on calcium oxalate (CaOx) crystallization in vitro. MATERIALS AND METHODS: CaOx crystallization was induced by adding sodium oxalate to synthetic urine. Taraxasterol (2.5, 5, 7.5 and 12.5 μg/mL), extract (1, 2, 4 and 8 mg/mL), and PC (100, 150, 200 and 350 mg/mL) were subjected to anti-crystallization activities. The absorbance and %inhibition of nucleation of CaOx c...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Measurement of daily sodium excretion in patients with chronic kidney disease; special reference to the difference between the amount measured from 24  h collected urine sample and the estimated amount from a spot urine.
Measurement of daily sodium excretion in patients with chronic kidney disease; special reference to the difference between the amount measured from 24 h collected urine sample and the estimated amount from a spot urine. Ren Fail. 2018 Nov;40(1):238-242 Authors: Amano H, Kobayashi S, Terawaki H, Ogura M, Kawaguchi Y, Yokoo T Abstract It is important to grasp a patient's daily sodium intake in the management of chronic kidney disease, as sodium intake is widely recommended at 6 g/day or less. There are multiple equations widely known for estimating the daily sodium excretion from a spot uri...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding.
Authors: Soni H, Kaminski D, Gangaraju R, Adebiyi A Abstract Acute kidney injury (AKI), a significant complication of cisplatin chemotherapy is associated with reactive oxygen species (ROS)-dependent renal cell death, but the cellular targets of ROS in cisplatin nephrotoxicity are not fully resolved. Here, we investigated cisplatin-induced oxidative renal damage and tested the hypothesis that ROS-dependent shedding of death activator Fas ligand (FasL) occurs in cisplatin nephropathy. We show that intraperitoneal injection of sulfobutyl ether-β-cyclodextrin (Captisol™)-solubilized cisplatin elevated the l...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.
CONCLUSIONS: Our findings support the clinical Treg defects in CKD patients with glomerular diseases, and the rationale of evaluating low-dose IL-2 treatment for selectively modulating CD4+ Tregs. PMID: 29619880 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Salvia przewalskii extract of total phenolic acids inhibit TLR4 signaling activation in podocyte injury induced by puromycin aminonucleoside in vitro.
CONCLUSIONS: SPE protects podocytes from PAN-induced injury at least partly through inhibiting TLR4 signaling. SPE is as strong as tacrolimus in inhibiting TLR4 signaling in podocytes. PMID: 29619899 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of mitofilin in left ventricular hypertrophy in hemodialysis patients.
Authors: Wu QS, He Q, He JQ, Chao J, Wang WY, Zhou Y, Lou JZ, Kong W, Chen JF Abstract Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to investigate the relationship between mitofilin and LVH in HD patients. A total of 98 HD patients and 32 healthy controls were included in the study. Serum N-terminal proBNP (NT-proBNP), endothelin-1 (ET-1), an...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Etiological analysis of graft dysfunction following living kidney transplantation: a report of 366 biopsies.
CONCLUSIONS: A biopsy is helpful for the diagnosis of graft dysfunction. De novo or recurrent renal disease, represented by IgAN, is a major cause of graft dysfunction following living kidney transplantation. PMID: 29619905 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Low lean tissue mass can be a predictor of one-year survival in hemodialysis patients.
CONCLUSIONS: Sarcopenia defined as decreased LTI, is a relatively common condition among patients undergoing maintenance hemodialysis, it can also be associated with a lower one-year survival rate. Decreased lean tissue mass can be associated with old age, lower IGF-1 levels and higher IL-6 levels. Body composition assessment may provide prognostic data for hemodialysis patients. PMID: 29620449 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Kinetics of carnitine concentration after switching from oral administration to intravenous injection in hemodialysis patients.
In this study, the mode of carnitine administration was changed from oral to IV in 17 hemodialysis (HD) patients, and the treatment was discontinued after 1 year. We found that the levels of total carnitine (TC), free-carnitine (FC), and acyl-carnitine (AC) significantly increased after 3 months of switching to IV administration (p 
Source: Renal Failure - April 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Does neutrophil to lymphocyte ratio demonstrate deterioration in renal function?
CONCLUSIONS: The NLR may constitute a practical predictor of CKD besides Cr in patients who had undergone partial or radical nephrectomy. PMID: 29616601 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Predictive role of endothelin in left ventricular remodeling of chronic kidney disease.
Authors: Peng T, Li X, Hu Z, Yang X, Ma C Abstract BACKGROUND: In chronic kidney disease (CKD), endothelin-1 (ET-1) always increases and there are changes in cardiac ultrasonography. In the present study, we aimed at investigating the role of serum ET-1 in predicting cardiac complications in patients with CKD. METHODS: The level of serum ET-1 was measured by enzyme-linked immunosorbent assay (ELISA) and cardiac ultrasonography was performed in enrolled patients. Indexes of heart failure, such as left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter, were meas...
Source: Renal Failure - March 29, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A novel uromodulin mutation in autosomal dominant tubulointerstitial kidney disease: a pedigree-based study and literature review.
This study presented a novel UMOD mutation in an ADTKD pedigree and reviewed studies in Chinese population. The index patient is a 16-year-old girl with hypertension, hyperuricemia and normal serum creatinine level. Four affected and six unaffected members were available for genetic screen. The mutation analysis was performed by next-generation sequencing and direct sequencing. A literature research was conducted to review Chinese ADTKD-UMOD cases. MEDLINE and Chinese Biomedicine Databases were searched with 'uromodulin', 'juvenile gout' and their related terms. Genetic sequencing revealed a de novo mutation within exon 3 ...
Source: Renal Failure - March 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Synergistic action of inflammation and lipid dysmetabolism on kidney damage in rats.
In this study, Wistar rats were randomized into four groups: normal diet + saline (Group N), high-fat diet (HF)+ saline (Group HF), normal diet + adriamycin (Group ADR), HF + adriamycin (Group ADR + HF). After 10 weeks of feeding, rats in each group were randomly sacrificed. We found that the protein content of urine in ADR and ADR + HF groups were significantly higher than that of group N and HF while the serum levels of total protein and albumin in the ADR and ADR + HF groups decreased correspondingly. The serum levels of tr...
Source: Renal Failure - March 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of accepted and unaccepted living kidney donors: one-center experience.
CONCLUSIONS: During an average of 101 months of follow-up mortality of accepted LD did not differ significantly as compared to the age standardized Serbian population and none of them developed ESRD. In examination of potential LD, the use of accurate and precise methods for kidney function estimation and the evaluation of risk for ESRD and mortality as well as treatment of modifiable contraindications for kidney donation are necessary. PMID: 29575953 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 28, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Recording blood pressure and eGFR in primary care after the Belgrade screening study.
CONCLUSIONS: Under-recording of blood pressure and eGFR in primary care health centers suggests lack of adherence to current guidelines and insufficient care of CKD patients. This implies the necessity for continuous education of physicians. PMID: 29565226 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - March 23, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Idiopathic sudden sensorineural hearing loss in dialysis patients.
Authors: Kang SM, Lim HW, Yu H Abstract Although sudden sensorineural hearing loss (SSNHL) affects chronic kidney disease (CKD) patients more frequently than non-CKD patients, few reports have described SSNHL in dialysis patients. We aimed to review the characteristics of SSNHL in chronic dialysis patients and evaluate treatment responses to steroid therapy. We retrospectively reviewed the records of dialysis patients diagnosed with idiopathic SSNHL at Asan Medical Center between January 2000 and December 2014. Pure tone and speech audiometry analyzes were performed before and 2 weeks and 2 months aft...
Source: Renal Failure - March 23, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Investigation of mechanisms of mesenchymal stem cells for treatment of diabetic nephropathy via construction of a miRNA-TF-mRNA network.
CONCLUSIONS: RPS27A, RPLP0 and ETF1 may be potential targets for MSCs on the treatment of DN. Highlights RPS27A and RPLP0 may be important genes in the treatment of MSCs for DN. TF EIF3M may play a key role in the treatment of MSCs for DN. MiR-150 and miR-134 may be essential microRNAs in the treatment of MSCs for DN. PMID: 29532746 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 15, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Correction to: Shu, et al., HIV/AIDS-related hyponatremia: an old but still serious problem.
Authors: PMID: 29461123 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 21, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

N-terminal-pro-B-type-natriuretic peptide associated with 2-year mortality from both cardiovascular and non-cardiovascular origins in prevalent chronic hemodialysis patients.
Authors: Kawagoe C, Sato Y, Toida T, Nakagawa H, Yamashita Y, Fukuda A, Iwatsubo S, Fujimoto S Abstract N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) was a predictive marker of cardiovascular disease (CVD)-related death in chronic dialysis patients. NT-proBNP was also correlated with markers of inflammation, malnutrition and protein-energy wasting. We hypothesized whether NT-proBNP was also associated with non-CVD death in chronic dialysis patients. A prospective observational study for incidence of death in chronic dialysis patients was conducted. Prevalent chronic dialysis patients (n = 1310...
Source: Renal Failure - February 20, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Obesity, acute kidney injury and mortality in patients with sepsis: a cohort analysis.
This study is retrospective including 456 adult patients with sepsis admitted to the Division of Intensive Medicine of the Centro Hospitalar Lisboa Norte (Lisbon, Portugal) between January 2008 and December 2014. Obesity was defined as a body mass index of 30 kg/m2 or higher. The Kidney Disease Improving Global Outcomes classification was used to diagnose and classify patients developing AKI. AKI occurred in 87.5% of patients (19.5% with stage 1, 22.6% with stage 2 and 45.4% with stage 3). Obese patients developed AKI more frequently than non-obese patients (92.8% versus 85.5%, p = .035; unadjusted OR ...
Source: Renal Failure - February 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Correction to: Lenihan, et al., MDRD-Estimated GFR at One Year Post-Renal Transplant is a Predictor of Long-Term Graft Function.
Authors: PMID: 29363390 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 25, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of health-related quality of life in hemolytic uraemic syndrome patients treated with eculizumab: a systematic evaluation on basis of EMPRO.
CONCLUSIONS: Evidence from present investigation support that eculizumab significantly improves HRQoL in patients with aHUS furthermore, EQ-5 D and VAS instrument should be recommended for assessing HRQoL in them. However, selection of PRO instrument for determination of QoL in HUS entirely depend upon the study requirements. PMID: 29363392 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 25, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis.
Authors: Hwang SD, Lee JH, Lee SW, Kim JK, Kim MJ, Song JH Abstract Overhydration and sarcopenia, related to an individual's nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to ...
Source: Renal Failure - January 21, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Assessment of preeclampsia risk by use of serum ionized magnesium-based equation.
Authors: Kreepala C, Kitporntheranunt M, Sangwipasnapaporn W, Rungsrithananon W, Wattanavaekin K Abstract BACKGROUND: Preeclampsia is a common medical complication in pregnancy. It has been reported to be associated with decreased serum magnesium levels. However, there has not been evidence demonstrating utilization of change in magnesium for prediction of preeclampsia. The purpose of this study was to develop magnesium fraction-based equations which took other significant clinical risk factors into consideration for prediction of preeclampsia. METHODS: We collected serum total and ionized magnesium ionized mag...
Source: Renal Failure - January 11, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of cholesterol overload on mouse kidney and kidney-derived cells.
CONCLUSIONS: These findings suggest that the increased cholesterol load on kidney contribute to the decrease of megalin and the overloaded cholesterol is taken into the renal tubule epithelial cells, causing suppression on cell proliferation, which may be the cause of kidney damage. PMID: 29304720 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - January 8, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism.
This study aimed to investigate the association of gastrointestinal (GI) adverse events of cinacalcet with gallstones in the hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). A total of 23 HD patients under the treatment with cinacalcet and 101 control patients were enrolled in this cross-sectional study. We investigated the prevalence of gallstones and the association of GI adverse events of cinacalcet with gallstones. The prevalence of gallstones was significantly higher in the HD patients with cinacalcet compared with the controls (47.8% vs. 15.8%). The longer time on HD, hypercalcemia, hyperp...
Source: Renal Failure - January 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Intensified treatment of hyperphosphatemia associated with reduction in parathyroid hormone in patients on maintenance hemodialysis.
This study investigated the therapeutic effect of intensive phosphorus-lowering therapy on intact-parathyroid hormone (iPTH) levels in hemodialysis patients. METHODS: Ninety-five hemodialysis patients with serum phosphorus ≥1.78 mmol/L and iPTH ≥300 pg/dL were apportioned to either the treatment or control group (n = 43 and 52, respectively) based on patient commitment to treatment. The treatment group was given phosphorus-lowering therapies with phosphate binders (lanthanum, sevelamer or/and calcium reagent) combined with dietary phosphate restriction and intensified hemodialysis. The...
Source: Renal Failure - January 5, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research