Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury
CONCLUSION: This study elucidated the role of cuproptosis in AKI and revealed the association between CRGs and infiltrated immune cells through comprehensive bioinformatic techniques. The six-gene cuproptosis-related signature exhibited remarkable predictive efficiency for AKI.PMID:38538321 | DOI:10.1080/0886022X.2024.2325035 (Source: Renal Failure)
Source: Renal Failure - March 27, 2024 Category: Urology & Nephrology Authors: Yajing Li Yingxue Ding Source Type: research
RfxCas13d-mediated inhibition of < em > Circ1647 < /em > alleviates renal fibrosis via PI3K/AKT signaling pathway
CONCLUSION: Our study suggests that Circ1647 plays a significant role in renal fibrosis by mediating the PI3K/AKT signaling pathway. RfxCas13d-mediated inhibition of Circ1647 may serve as a therapeutic target for renal fibrosis in CKD.PMID:38527916 | PMC:PMC10964833 | DOI:10.1080/0886022X.2024.2331612 (Source: Renal Failure)
Source: Renal Failure - March 25, 2024 Category: Urology & Nephrology Authors: Yufang Ni Hongmin Zhang Qianwen Xian Wenjie Qin Hongwei Su Li Wang Jianchun Li Source Type: research
RfxCas13d-mediated inhibition of < em > Circ1647 < /em > alleviates renal fibrosis via PI3K/AKT signaling pathway
CONCLUSION: Our study suggests that Circ1647 plays a significant role in renal fibrosis by mediating the PI3K/AKT signaling pathway. RfxCas13d-mediated inhibition of Circ1647 may serve as a therapeutic target for renal fibrosis in CKD.PMID:38527916 | DOI:10.1080/0886022X.2024.2331612 (Source: Renal Failure)
Source: Renal Failure - March 25, 2024 Category: Urology & Nephrology Authors: Yufang Ni Hongmin Zhang Qianwen Xian Wenjie Qin Hongwei Su Li Wang Jianchun Li Source Type: research
Recent advances in the application of Mendelian randomization to chronic kidney disease
CONCLUSION: This review not only presents the recent achievements of MR in CKD research but also illuminates the path forwards, underscoring critical unanswered questions and proposing future research directions in this dynamic field.PMID:38522953 | DOI:10.1080/0886022X.2024.2319712 (Source: Renal Failure)
Source: Renal Failure - March 24, 2024 Category: Urology & Nephrology Authors: Chaofan Wen Lanlan Chen Dan Jia Ziqi Liu Yidan Lin Guan Liu Shuo Zhang Baoshan Gao Source Type: research
The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study
CONCLUSION: Elevated MHR level was independently associated with the presence of CKD, suggesting that it might serve as a useful clinical tool for risk stratification, offering valuable insights to inform preventive and therapeutic approaches for clinicians in their routine medical practice.PMID:38522954 | PMC:PMC10962299 | DOI:10.1080/0886022X.2024.2331614 (Source: Renal Failure)
Source: Renal Failure - March 24, 2024 Category: Urology & Nephrology Authors: Lingling Xu Dongling Li Zongwei Song Jin Liu Yang Zhou Junwei Yang Ping Wen Source Type: research
Effect of angiotensin-converting enzyme inhibitors < em > versus < /em > that of angiotensin receptor blockers on survival in patients undergoing hemodialysis: a nationwide observational cohort study
CONCLUSIONS: Our study found that patients receiving ACEI and ARB had comparable survival. However, patients receiving ARB had better survival in the subgroups of patients with DM or heart disease, and patients receiving ACEI had better survival in the subgroup of young patients or patients without diabetes or heart disease.PMID:38522955 | PMC:PMC10962295 | DOI:10.1080/0886022X.2024.2313173 (Source: Renal Failure)
Source: Renal Failure - March 24, 2024 Category: Urology & Nephrology Authors: Seok Hui Kang Gui Ok Kim Bo Yeon Kim Eun Jung Son Jun Young Do Source Type: research
Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention
Ren Fail. 2024 Dec;46(1):2331062. doi: 10.1080/0886022X.2024.2331062. Epub 2024 Mar 21.ABSTRACTCardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may resu...
Source: Renal Failure - March 22, 2024 Category: Urology & Nephrology Authors: Xutao Yang Li Zhu Hong Pan Yi Yang Source Type: research
Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention
Ren Fail. 2024 Dec;46(1):2331062. doi: 10.1080/0886022X.2024.2331062. Epub 2024 Mar 21.ABSTRACTCardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may resu...
Source: Renal Failure - March 22, 2024 Category: Urology & Nephrology Authors: Xutao Yang Li Zhu Hong Pan Yi Yang Source Type: research
Machine learning model and nomogram to predict the risk of heart failure hospitalization in peritoneal dialysis patients
CONCLUSIONS: We developed and validated a novel method to predict the risk factors of HF and all-cause mortality that integrates readily available clinical, laboratory, and electrocardiographic variables to predict the risk of HF among PD patients.PMID:38494197 | PMC:PMC10946267 | DOI:10.1080/0886022X.2024.2324071 (Source: Renal Failure)
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Liping Xu Fang Cao Lian Wang Weihua Liu Meizhu Gao Li Zhang Fuyuan Hong Miao Lin Source Type: research
Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf- κb pathway
Ren Fail. 2024 Dec;46(1):2330629. doi: 10.1080/0886022X.2024.2330629. Epub 2024 Mar 17.ABSTRACTAcetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased lev...
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Yachen Si Lulu Liu Yinyin Zhang Hongxia Li Tingting Zhao Su Liu Xuejun Sun Jin Cheng Hongtao Lu Source Type: research
Machine learning model and nomogram to predict the risk of heart failure hospitalization in peritoneal dialysis patients
CONCLUSIONS: We developed and validated a novel method to predict the risk factors of HF and all-cause mortality that integrates readily available clinical, laboratory, and electrocardiographic variables to predict the risk of HF among PD patients.PMID:38494197 | PMC:PMC10946267 | DOI:10.1080/0886022X.2024.2324071 (Source: Renal Failure)
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Liping Xu Fang Cao Lian Wang Weihua Liu Meizhu Gao Li Zhang Fuyuan Hong Miao Lin Source Type: research
Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf- κb pathway
Ren Fail. 2024 Dec;46(1):2330629. doi: 10.1080/0886022X.2024.2330629. Epub 2024 Mar 17.ABSTRACTAcetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased lev...
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Yachen Si Lulu Liu Yinyin Zhang Hongxia Li Tingting Zhao Su Liu Xuejun Sun Jin Cheng Hongtao Lu Source Type: research
