Therapy with atorvastatin versus rosuvastatin reduces urinary podocytes, podocyte-associated molecules, and proximal tubule dysfunction biomarkers in patients with type 2 diabetes mellitus: a pilot study.
Authors: Vlad A, Vlad M, Petrica L, Ursoniu S, Gadalean F, Popescu R, Vlad D, Dumitrascu V, Gluhovschi G, Gluhovschi C, Velciov S, Bob F, Matusz P, Secara A, Simulescu A, Jianu DC Abstract BACKGROUND: Diabetic nephropathy is a severe complication of Type 2 diabetes. Tubular lesions may play an important role in its early stages. The aim of our study was to determine if atorvastatin protects the podocytes and the proximal tubule in patients with Type 2 diabetes. METHODS: A total of 63 patients with Type 2 diabetes completed this 6-months prospective pilot study. They were randomized to continue rosuvastatin ther...
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Left ventricle ejection fraction may predict mortality in renal transplant patients.
Authors: Ozkul F, Kasim Arik M, Erbiş H, Akbaş A, Yilmaz VT, Barutcu A, Ali Osmanoğlu I, Kocak H Abstract PURPOSE: Mortality is a major problem in renal transplant patients, and appropriate preoperative evaluation is very important. We retrospectively reviewed the left ventricle ejection fraction (LVEF) of renal transplant patients. MATERIAL AND METHODS: The clinical records of 1763 patients who had preoperative LVEF results and who underwent renal transplantation at Akdeniz University Faculty of Medicine during the years 2004-2014 were studied. The LVEF limit was set at 55%. LVEF, age, gender, diabetes mell...
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats.
This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with sitagliptin in experimentally induced diabetic nephropathy. The diabetic rats were treated with coenzyme Q10 or sitagliptin and their concomitant administration. Various parameters of renal function like serum creatinine, urea, uric acid and markers of oxidative stress such as renal malondialdehyde content (MDA), glutathione (GSH) level and superoxide dismutase (SOD), catalase activities were measured. TNF-α, TGF-β, MPO activity and nitrite content were estimated in renal tissue with histopathological observati...
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Efficacy of microwave ablation for severe secondary hyperparathyroidism in subjects undergoing hemodialysis.
Authors: Diao Z, Wang L, Li D, Liu W Abstract Severe secondary hyperparathyroidism (SHPT) is a serious problem in patients undergoing hemodialysis. The efficacy and safety of microwave ablation (MWA), a minimally invasive treatment, for severe SHPT are as yet unclear. To clarify the role of MWA, we administered it to patients with severe SHPT and assessed its efficacy and safety. This was a prospective, single-center, single-arm, clinical trial. We enrolled patients with severe SHPT attending our hemodialysis center who met the inclusion and exclusion criteria. We then assessed primary outcome measures (serum conce...
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

N-acetylcysteine protects against star fruit-induced acute kidney injury.
CONCLUSIONS: Our data show that therapeutic NAC attenuates renal dysfunction in a model of acute oxalate nephropathy following SF ingestion by reducing oxidative stress, oxaluria, and inflammation. This might represent a novel indication of NAC for the treatment of SF-induced AKI. PMID: 27845599 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Establishment and observation of a new and ideal reversible model of PUUO.
CONCLUSIONS: Those findings indicate our procedure generate a successful and reversible PUUO animal model. It is a reliable and simple procedure for generating an animal model for reversible PUUO. The feasibility and significance of the new method was confirmed through ultrasonographic and pathological results. PMID: 27845607 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of Silybum marianum and Taraxacum officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats.
Authors: Karakuş A, Değer Y, Yıldırım S Abstract The protective effect of the extracts of the plants Silybum marianum and Taraxacum officinale by carbon tetrachloride (CCl4) was researched. Sixty-six female Wistar albino rats were divided into six groups: Control, Silybum marianum, Taraxacum officinale, CCl4, Silybum marianum+ CCl4, Taraxacum officinale+CCl4. The Silybum marianum and Taraxacum officinale extracts were administered as 100 mg/kg/day by gavage. The CCl4 was administered as 1.5 mL/kg (i.p.). At the end of the trial period, in the serums obtained from the animals, in the CCl4 gro...
Source: Renal Failure - November 16, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Screening Fabry's disease in chronic kidney disease patients not on dialysis: a multicenter study.
CONCLUSION: Fabry's disease should be considered in the differential diagnosis of chronic kidney disease with unknown etiology even in the absence of symptoms and signs suggestive of Fabry's disease. PMID: 27832731 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - November 14, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of abnormal radiological findings in children aged 2 to 36 months followed by recurrent urinary tract infection: a retrospective study.
This study was enrolled children aged between 2 and 36 months, following-up with the diagnosis of recurrent UTI. All children had ultrasonography (USG) and dimercaptosuccinic acid scanning, 39 of them had underwent on voiding cystourethrography. There were 133 children (87 girls, 46 boys) with the mean age of 32.82 ± 38.10 months included into the study. Forty-three kidney units were normal in ultrasonogram of which seven units had reflux whereas among 35 units with hydronephrosis 22 units had reflux. Sensitivity and specificity presence of hydronephrosis in ultrasonogram for prediction of reflux was 7...
Source: Renal Failure - November 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Efficacy of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome.
Authors: Liu Y, Qu X, Chen W, Zhang Y, Liu L Abstract OBJECTIVE: To assess the safety and clinical efficacy of leflunomide (LEF) and prednisone on refractory nephrotic syndrome (RNS). METHODS: A total of 52 patients with RNS were treated for 24 weeks between 2010 and 2014 in our hospital. In the treated group, 26 patients were treated with LEF and prednisone, and, in the control group, 26 patients were treated with cyclophosphamide (CTX) and prednisone. During the treatment, 24 h urinary protein excretion and the serum levels of albumin and cholesterol, and kidney function were assayed before and after t...
Source: Renal Failure - November 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Neutrophil gelatinase-associated lipocalin in a triphasic rat model of adenine-induced kidney injury.
Authors: Gil A, Brod V, Awad H, Heyman SN, Abassi Z, Frajewicki V Abstract The aim of this study is to investigate whether NGAL, given its advantages over traditional biomarkers, can be used to describe the dynamic characteristics of the renal tubulointerstitial insult caused by adenine. Subsequently, it will be possible to assess NGAL as a biomarker of any acute kidney injury, on top of chronic interstitial disease, if NGAL levels are stable through the chronic phase of our adenine model. Study group rats were fed an adenine diet, and control group rats were fed a regular diet only. Blood and urine samples for ure...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors of acute kidney injury after acute myocardial infarction.
CONCLUSIONS: AKI is a common complication and associated with increased mortality after AMI. Decreased baseline renal function, increased FPG and use of diuretics were common independent risk factors of AKI after AMI. PMID: 27300258 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Human embryonic mesenchymal stem cells alleviate pathologic changes of MRL/Lpr mice by regulating Th7 cell differentiation.
Authors: Yuan L, Xiao ZT, Huang XZ, Wu MJ, Shi H, Liu AF Abstract Recent evidence indicates that mesenchymal stem cells (MSC) derived from early embryonic tissues have better therapeutic ability as compared with adult tissue-derived stem cells. In the present study, we transplanted human early embryonic MSC (hMSC) into MRL/Lpr mice via tail vein injection to observe the therapeutic efficacy of hMSC and their impact on T helper 17 (Th17) cell differentiation in MRL/Lpr mice. Animals in hMSC treatment group received hMSC (1 × 10(6)/200 μL) via the tail vein at the age of 16 and 19 weeks. We fou...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal functional reserve and renal hemodynamics in hypertensive patients.
Authors: Gaipov A, Solak Y, Zhampeissov N, Dzholdasbekova A, Popova N, Molnar MZ, Tuganbekova S, Iskandirova E Abstract The renal functional reserve (RFR) is the ability of the kidneys to increase renal plasma flow and glomerular filtration rate (GFR) in response to protein intake. It is a measure of functional and anatomic integrity of nephrons. It is not known what relation between RFR and kidney Doppler parameters. We aimed to study the relation between the RFR and renal hemodynamic parameters in hypertensive patients with and without nephropathy who had normal kidney function. Twenty-four hypertensive subjects ...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Active CMV and EBV infections in renal transplant recipients with unexplained fever and elevated serum creatinine.
Authors: Hasannia T, Moosavi Movahed SM, Vakili R, Rafatpanah H, Hekmat R, Valizadeh N, Rezaee SA Abstract Proper identification of active cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are helpful for monitoring antiviral treatment in transplant recipients. Qualitative and quantitative CMV, EBV DNA PCR techniques in the context of serological tests are performed for early detection and differentiation of active and latent CMV and EBV infections in renal transplantation. Basically, 129 renal transplanted recipients monitored carefully and hospitalized for unexplained elevated creatinine levels or hig...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal ischemia/reperfusion against nephrectomy for induction of acute lung injury in rats.
CONCLUSION: Acutely accumulated systemic mediators following renal failure in the absence of kidneys vary from those due to combined renal failure with ischemic-reperfused kidneys and consequently they induce ALI with distinct characteristics. PMID: 27484785 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats.
CONCLUSION: It is concluded that NMDA receptor antagonism significantly contributes towards curcumin-mediated protection against I/R-induced AKI. PMID: 27484883 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ischemic post-conditioning attenuates renal ischemic reperfusion injury via down-regulation of toll-like receptor 4 in diabetic rats.
CONCLUSION: Taken together, our results suggest that proper IPO may have protective effect on the ischemic injury mediated by renal I/R, which might be associated with inhibition of TLR4 signaling pathway in diabetic rats. PMID: 27494109 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Non-steroidal anti-inflammatories and the development of analgesic nephropathy: a systematic review.
CONCLUSION: A relationship between non-steroidal anti-inflammatory medicines and the development of CKD has never been proven. Based on the available scientific evidence non-steroidal anti-inflammatory agents do not appear to be implicated in the pathogenesis of AN. PMID: 27494231 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Community-acquired hyperkalemia in elderly patients: risk factors and clinical outcomes.
This study was performed to investigate the risk of CAH in elderly and evaluate the related factors and clinical outcomes. Study design, setting and participants, intervention: Patients (aged ≥65 years) with hyperkalemia were screened. Group 1 (young-old); 65-74 years/old, Group 2 (middle-old); 75-84 years/old, Group 3 (oldest-old); ≥85 years/old, and Group 4 (control group); ≥65 years/old (normal serum potassium levels). The relation between CAH and hospital expenses (HE), the number of comorbid diseases (NCD), and all-cause of mortality rates (MR) were evaluated. We also investigated whether drugs, sex, and NCD ...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between GSTM1, GSTT1, and GSTP1 variants and the risk of end stage renal disease.
Authors: Nomani H, Hagh-Nazari L, Aidy A, Vaisi-Raygani A, Kiani A, Rahimi Z, Bahrehmand F, Shakiba E, Mozaffari HR, Tavilani H, Pourmotabbed T Abstract INTRODUCTION: There are some evidences indicating DNA damage by oxidant and mutant agents has an essential role in the chronic renal failure and end stage renal disease (ESRD). To investigate the possible association of GSTs variants with ESRD, we investigated the frequency of GST- T1, M1, and P1 genotypes, and the level of malondialdehyde (MDA) in patients with ESRD. MATERIALS AND METHODS: The present case-control study consisted of 136 ESRD patients treated w...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of angiotensin-converting enzyme insertion/deletion polymorphism with type 1 diabetic nephropathy: a meta-analysis.
This study aimed to systematically evaluate the effect of an angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism on type 1 diabetic nephropathy (DN). METHODS: Cochrane Library, Embase, PubMed, Science Direct, Web of science, Wanfang data, VIP database, China Knowledge Resource Integrated Database, and SinoMed were searched. A total of 17 case-control studies analyzing ACE I/D polymorphism and type 1 DN risk were included in the present meta-analysis. RESULTS: Overall, a significant increased risk was found in allele comparison (OR = 1.16, 95% CI = 1.05-1.28, p&...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis.
High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis. Ren Fail. 2016 Oct;38(9):1370-1376 Authors: Chimenz R, Lacquaniti A, Colavita L, Chirico V, Fede C, Buemi M, Fede C Abstract BACKGROUND: Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role as precocious marker of peritoneum ...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

18 β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants. Ren Fail. 2016 Oct;38(9):1516-1527 Authors: Abd El-Twab SM, Hozayen WG, Hussein OE, Mahmoud AM Abstract OBJECTIVES: 18β-glycyrrhetinic acid (18β-GA) has multiple beneficial and therapeutic effects. However, its protective roles on methotrexate (MTX)-induced renal injury are not well defined. In the present study, we investigated the possible protective effects of 18β-GA against MTX-induced nephrotoxicity in rats. MATERIALS: 18β-...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urinary kidney injury molecules in children with febrile seizures.
Authors: Güneş A, Ece A, Akça H, Aktar F, Mete Ş, Samanci S, Uluca Ü, Şen V, Tan İ, Kaplan İ Abstract OBJECTIVE: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time. METHODS: The study included 28 children with FS and 34 age and gender matched hea...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical and pathological analysis of IgA nephropathy with chronic renal failure.
CONCLUSION: IgA nephropathy with chronic renal failure usually occurred in young adults, and it had severe clinical condition and pathological changes, while there was no significant relationship between them. PMID: 27558026 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.
CONCLUSIONS: Our data indicate that AGM has a protective effect against cisplatin-induced nephrotoxicity. Therefore, it may improve the therapeutic index of cisplatin. In addition, the early renal damage induced by cisplatin and protective effects of AGM against cisplatin nephrotoxicity was accurately demonstrated with 99mTc-DMSA renal scintigraphy. PMID: 27604130 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Alterations in morphology and hepatorenal indices in rats subacutely exposed to bitumen extract.
In this study, bitumen obtained from a seepage source in Agbabu, the town of first discovery, was used in sub-acute toxicity studies in a rat experimental model, in order to assess potential health risks posed to local populace sequel to full exploitation of bitumen. Dosages were chosen to accommodate low to high cases of environmental exposures. Male Wistar rats were administered, per os, dosages of bitumen extract at 5, 3, 2, and 1 mg/kg body weight. Following euthanasia 28 days later, histological findings revealed severe portal congestion and cellular infiltration in the liver, while in the kidney there were pro...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Amelioration of cisplatin-induced acute kidney injury by recombinant neutrophil gelatinase-associated lipocalin.
Authors: Ma Q, Devarajan SR, Devarajan P Abstract We investigated the protective effect and mechanism of neutrophil gelatinase-associated lipocalin (NGAL) in a murine model of cisplatin-induced nephrotoxicity. Male Swiss-Webster mice were assigned to four groups (n = 10 in each group). Control mice received vehicle only. Mice in the experimental group were given a single intraperitoneal injection of cisplatin (20 mg/kg) to induce nephrotoxicity, and were divided into three groups. The first group received 100 μL of saline only via tail vein at the time of cisplatin administration. The...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of mutant lactobacilli on serum creatinine and urea nitrogen concentrations and renal pathology in 5/6 nephrectomized rats.
Authors: Wang F, Jiang YS, Liu F Abstract OBJECTIVES: To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS: Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model group, a wide-type Lactobacilli group (L.B group), and a Mutant Lactobacilli group (Mut-L.B group). The rats in the Model, LB and Mut-L.B groups underwent 5/6 nephrectomy. Eight weeks after administration, 24-h urine, orbital blood and digestive secretions...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical outcomes with a systolic blood pressure lower than 120  mmHg in older patients with high disease burden.
Clinical outcomes with a systolic blood pressure lower than 120 mmHg in older patients with high disease burden. Ren Fail. 2016 Oct;38(9):1364-1369 Authors: Franco Palacios CR, Haugen EN, Thompson AM, Rasmussen RW, Goracke N, Goyal P Abstract BACKGROUND: The target blood pressure in older patients is controversial. Recent studies provided clinical evidence supporting a target systolic blood pressure 50 years at high risk of cardiovascular events. METHODS: Retrospective study of 380 consecutive patients ≥60 years with stages 1-5 pre-dialysis chronic kidney disease seen between January 2013...
Source: Renal Failure - November 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Identification of crucial miRNAs and the targets in renal cortex of hypertensive patients by expression profiles.
CONCLUSION: Three crucial genes were identified in hypertensive kidney, such as COL12A1, ASPN, and SCN2A. ASPN might co-function with COL12A1, and they both might be the targets of miR-21. SCN2A might be a novel target of miR-30e and miR-374b. However, more experiments are needed to validate these results. PMID: 27802793 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - November 4, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Xuezhikang ameliorates contrast media-induced nephropathy in rats via suppression of oxidative stress, inflammatory responses and apoptosis.
CONCLUSION: XZK's therapeutic effect is similar, or even better than atorvastatin at the same effectual dose in some parts. PMID: 27800691 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - November 2, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Study of the role of tumor necrosis factor- α (-308 G/A) and interleukin-10 (-1082 G/A) polymorphisms as potential risk factors to acute kidney injury in patients with severe sepsis using high-resolution melting curve analysis.
Study of the role of tumor necrosis factor-α (-308 G/A) and interleukin-10 (-1082 G/A) polymorphisms as potential risk factors to acute kidney injury in patients with severe sepsis using high-resolution melting curve analysis. Ren Fail. 2016 Oct 27;:1-6 Authors: Hashad DI, Elsayed ET, Helmy TA, Elawady SM Abstract RATIONAL: Septic acute kidney injury (AKI) is a prevalent complication in intensive care units with an increased incidence of complications. OBJECTIVE: The aim of the present study was to assess the use of high-resolution melting curve (HRM) analysis in investigating w...
Source: Renal Failure - November 1, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renoprotective effect of Bacopa monnieri via inhibition of advanced glycation end products and oxidative stress in STZ-nicotinamide-induced diabetic nephropathy.
This study was designed to evaluate the effect of alcohol and hydroalcohol extract of Bacopa monnieri and stigmasterol isolated from B. monnieri in the treatment of DN. Diabetes was induced in male wistar rats by streptozotocin (65 mg/kg i.p.) 15 min after nicotinamide (230 mg/kg, i.p.) administration. After 30 days, the rats were treated with different doses of extracts (100, 200, and 400 mg/kg) and stigmasterol (5 and 10 mg/kg) for 45 days to analyze their nephroprotective effect and produced significant attenuation in the serum glucose level, uric acid, creatinine, and lipid levels. Mo...
Source: Renal Failure - October 28, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of histopathologic and clinical features on allograft survival in renal transplant patients with antibody-mediated rejection.
CONCLUSIONS: Serum creatinine at time of biopsy, tubulitis, intimal arteritis and interstitial infiltration were significantly associated with graft survival. Antibody-mediated rejection is associated with reduced long-term graft survival. PMID: 27776435 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Impact of acute kidney injury on renal allograft survival.
CONCLUSION: Renal transplant recipients have high risk for AKI and it hampers long-term graft survival. PMID: 27776444 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Quality of life, clinical outcome, personality and coping in chronic hemodialysis patients.
Authors: D'Onofrio G, Simeoni M, Rizza P, Caroleo M, Capria M, Mazzitello G, Sacco T, Mazzuca E, Panzino MT, Cerantonio A, Segura-Garcia C, Andreucci M, De Fazio P, Fuiano G Abstract RATIONAL: Our aim was to investigate the quality of life (QoL) in 103 patients undergoing chronic hemodialysis (HD) in an integrated assessment of clinical, personological, and adaptation parameters, also in a non-urban context. OBJECTIVES: We collected data from all chronic HD patients attending four HD units. Clinical status was assessed by Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines and by Age-adjusted Charlson...
Source: Renal Failure - October 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Potassium supplementation and long-term outcomes in chronic peritoneal dialysis patients with end-stage renal disease: a propensity score matching study.
Authors: Zhang YF, Wang Q, Su YY, Yang S, Guo J, Luo J, Tang JM, Li HY Abstract OBJECTIVE: In this retrospective matched-cohort study, the association between potassium supplementation and long-term outcomes was determined. METHODS: Chronic peritoneal dialysis (PD) patients, aged ≥ 16 years, being referred to four PD centers in China, with serum potassium levels ≤ 3.5 mEq/L on three consecutive monthly in Q4 2008 and without receiving oral potassium supplementation in the prior three months were included in this study. Patients were divided into two groups, either to receive (test group) or ...
Source: Renal Failure - October 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy.
CONCLUSION: Treatment using BM-MSCs is determined to be definitely effective in cases of diabetes and diabetic nephropathy. PMID: 27774826 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors of severe peritoneal sclerosis in chronic peritoneal dialysis patients.
In this study, we searched for possible risk factors of EPS. Data were collected from two PD centers covering period 1995-2012 and comprised 464 patients. Control group defined as PD patients stayed on PD>42 month (n = 122), and case group was 12 confirmed EPS patients. Associations were analyzed using linear regression analysis. Prevalence and incidence of EPS were 2.59% and 8.9% with an incidence of 0.7% patient-years, respectively. The age at start of PD in EPS patients (32.75 ± 10.8 year) was significantly lower compared with control group (49.61 ± 16.18 year, ...
Source: Renal Failure - October 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Which echocardiographic parameter is a better marker of volume status in hemodialysis patients?
CONCLUSION: Our results showed a correlation between IVCDimin and BIA parameters before HD. So, it seems that IVCDimin can be a good parameter for determining the volume status of HD patients. However, further studies, with larger sample size and with a prospective study design, are required to confirm these results. PMID: 27764980 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Luteolin ameliorates colistin-induced nephrotoxicity in the rat models.
CONCLUSION: The results obtained from this study demonstrated us that luteolin was capable of preventing colistin-induced nephrotoxicity and that this effect was significant at histopathological level. PMID: 27764981 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Familial juvenile hyperuricemic nephropathy as rare cause of dialysis-dependent chronic kidney disease-a series of cases in two families.
Authors: Kaminska-Pajak KA, Dyga K, Adamczyk P, Szczepańska M, Zaniew M, Beck B, Tkaczyk M Abstract Hyperuricemia is a common symptom in adult population. It usually accompanies the chronic kidney disease. Less frequently, it is a primary phenomenon causing later serious clinical consequences. Familial juvenile hyperuricemic nephropathy (FJHN) is one of the hereditary conditions associated with high levels of serum uric acid and leading to dialysis in young adult age. It results from mutation in the UMOD gene, encoding the uromodulin protein, that is, Tamm-Horsfall protein. The aim of this paper was to present two...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

End-stage renal disease adherence questionnaire: translation and validation to the portuguese language.
In conclusion, our results showed that PESRD-AQ, which presented an acceptable reliability and validity, is a valid tool to be used for adherence evaluation by Portuguese-speaking dialysis patients. PMID: 27764984 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure.
CONCLUSION: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients. PMID: 27764985 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Helicobacter pylori participates in the pathogenesis of IgA nephropathy.
This study aimed to investigate the risk incidence of IgAN caused by Hp infection. 22 primary IgAN, 20 non-IgA nephropathy (n-IgAN), and 30 healthy controls were included in this study. We found that the rate of IgG anti-Hp seropositivity was significantly improved in IgAN, but the current Hp infection was similar in all groups. The production and underglycosylation of IgA1 tended to increase in IgAN patients with IgG anti-Hp seropositivity. A tendency toward increased the risk of clinical prognosis was seen in IgAN with Hp infection. Hp antigen and CagA were only deposited in renal tubules, and enhanced antigen deposition...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies.
CONCLUSIONS: Our meta-analysis suggested that more than one-quarter of CKD sufferers, especially those who were on dialysis, were plagued by RLS. Higher sensitivity of diagnostic criteria in interview may be valuable for timely treatment. PMID: 27765002 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of hyperbaric oxygen therapy on rhabdomyolysis-induced myoglobinuric acute renal failure in rats.
Authors: Cebi G, Yildiz Ş, Uzun G, Oztas Y, Sabuncuoglu S, Kutlu A, Ilgaz Y, Karatop-Cesur I, Dogan E, Oztas E Abstract Myoglobinuric acute renal failure (MARF) may develop after severe muscle injury. Heme oxygenase-1 (HO-1), a stress-response protein, has been implicated as a protective agent against MARF. We hypothesized that hyperbaric oxygen therapy (HBOT) may alleviate MARF by inducing renal HO-1 expression. Wistar-Albino rats were randomly assigned into three groups: Control (n = 4), MARF (n = 8), MARF + HBO (n = 8). MARF was induced by intramuscular gl...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Etiology, clinical profile and short-term outcome of acute kidney injury in children at a tertiary care pediatric nephrology center in Pakistan.
Authors: Tresa V, Yaseen A, Lanewala AA, Hashmi S, Khatri S, Ali I, Mubarak M Abstract BACKGROUND: The reported prevalence rates and etiologies of acute kidney injury (AKI) are quite variable in different regions of the world. The current study was planned to determine the etiology, clinical profile, and short-term outcome of pediatric AKI at our hospital. METHODS: A prospective, observational study was carried out from April 2014 to March 2015. All pediatric patients (1 month to ≤15 years) diagnosed as AKI using modified pRIFLE criteria were studied and followed for 3 months to document short-term ou...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research