Analysis of chronic kidney disease epidemiology in Kazakhstan using nationwide data for 2014-2020 and forecasting future trends of prevalence and mortality for 2030
This study aims to examine the epidemiology of CKD in Kazakhstan and to project future trends in CKD prevalence and mortality by 2030. The retrospective analysis was performed on a database acquired from the Unified National Electronic Health System for 703,122 patients with CKD between 2014 and 2020. During the observation period, 444,404 women and 258,718 men were registered with CKD, 459,900 (66%) were Kazakhs and 47% were older than 50. The incidence rate notably decreased: 6365 people per million population (PMP) in 2014 and 4040 people PMP in 2020. The prevalence changed from 10,346 to 38,287 people PMP, and the mort...
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Gulnur Zhakhina Kamilla Mussina Sauran Yerdessov Arnur Gusmanov Yesbolat Sakko Valdemir Kim Dmitriy Syssoyev Meruyert Madikenova Ainur Assan Zhanat Kuanshaliyeva Duman Turebekov Kuanysh Yergaliyev Bolat Bekishev Abduzhappar Gaipov Source Type: research
The relationship between thiamin, folic acid and cognitive function in a rat model of uremia
Ren Fail. 2024 Dec;46(1):2329257. doi: 10.1080/0886022X.2024.2329257. Epub 2024 Mar 14.ABSTRACTEnd-stage renal disease is a worldwide health burden, but the pathogenesis of uremia-associated cognitive impairment (CI) is poorly recognized. We hypothesized that uremia brings about deficiency of thiamin and folic acid and causes CI by inducing oxidative stress. Therefore, 24 Sprague-Dawley rats were randomly divided into two groups: a 5/6 nephrectomy group (n = 12) and a sham-operated group (n = 12). The Morris water maze was used to assess the cognitive function eight weeks post-surgery, and serum levels of thiamin, folic ac...
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Yifei Lu Chenqi Xu Kewei Xie Bingru Zhao Minzhou Wang Cheng Qian Xuemei Chen Leyi Gu Wangshu Wu Renhua Lu Source Type: research
Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation
CONCLUSION: Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. While the trends discerned from the literature emerging opportunities in diagnostic innovation, renal microcirculation research, and precision medicine interventions, their translation to clinical practice is anticipated to be a deliberate process.PMID:38482598 | DOI:10.1080/0886022X.2024.2329249 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Bing Wang Mengting Xu Sunjing Fu Yingyu Wang Hao Ling Yuan Li Bingwei Li Xueting Liu Qin Ouyang Xiaoyan Zhang Ailing Li Xu Zhang Mingming Liu Source Type: research
TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF- κB signaling pathway
CONCLUSION: TAK-242 can improve oxidative stress, mitochondrial dysfunction, and inflammatory response by inhibiting the activity of TLR4/NF-κB signaling pathway, thereby preventing rats from SA-AKI.PMID:38482886 | DOI:10.1080/0886022X.2024.2313176 (Source: Renal Failure)
Source: Renal Failure - March 14, 2024 Category: Urology & Nephrology Authors: Yan-Mei Xia Yu-Qian Guan Ji-Fang Liang Wei-Dong Wu Source Type: research
Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model
CONCLUSIONS: This study provides evidence that the consumption of a HFD induces modifications in the composition and functionality of the gut microbiome in rats, which may serve as a potential mechanism underlying the relationship between obesity and the progression of kidney function decline.PMID:38469667 | DOI:10.1080/0886022X.2024.2328320 (Source: Renal Failure)
Source: Renal Failure - March 12, 2024 Category: Urology & Nephrology Authors: Akehu Alemasi Lijiang Gu Yilun Zhou Source Type: research
Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats
In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both in vivo and in vitro, validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD ...
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Lei Zhang Xingzhi Wang Liang Chang Yiqun Ren Manshu Sui Yuting Fu Lei Zhang Lirong Hao Source Type: research
Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study
CONCLUSIONS: Patients with ICI-AKI were more likely to have impaired renal function at baseline and after treatment with antibiotics. Approximately half of the patients achieved renal recovery.PMID:38466161 | PMC:PMC10930152 | DOI:10.1080/0886022X.2024.2326186 (Source: Renal Failure)
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Ping Zhou Bing Liu Ning Shen Xiaoting Fan Shangwei Lu Zhijuan Kong Ying Gao Zhimei Lv Rong Wang Source Type: research
What came first, atypical hemolytic uremic syndrome or malignant hypertension: a clinical dilemma
Ren Fail. 2024 Dec;46(1):2327484. doi: 10.1080/0886022X.2024.2327484. Epub 2024 Mar 11.NO ABSTRACTPMID:38466192 | PMC:PMC10930089 | DOI:10.1080/0886022X.2024.2327484 (Source: Renal Failure)
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Sidharth Kumar Sethi Savita S Aishwarya Nair Kritika Soni Shyam Bihari Bansal Abhyuday S Rana Rupesh Raina Source Type: research
Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review
Ren Fail. 2024 Dec;46(1):2323160. doi: 10.1080/0886022X.2024.2323160. Epub 2024 Mar 11.ABSTRACTAnti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output. A renal biopsy revealed crescent glomerulonephritis with linea...
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Zewei Chen Dechao Xu Fangzheng Cui Huihui Hou Zhiguo Mao Xiang Gao Source Type: research
External validation of the prediction model of intradialytic hypotension: a multicenter prospective cohort study
CONCLUSION: Externally validated, recalibrated, updated, and presented IDH prediction models may serve as a valuable instrument for evaluating IDH risk in clinical practice. Furthermore, they hold the potential to guide clinical providers in discerning individuals at risk and facilitating judicious clinical intervention decisions.PMID:38466674 | PMC:PMC10930093 | DOI:10.1080/0886022X.2024.2322031 (Source: Renal Failure)
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Yuhe Xiang Guoting Ma Qin Yang Min Cao Wenbin Xu Lin Li Qian Yang Source Type: research
Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats
In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both in vivo and in vitro, validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD ...
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Lei Zhang Xingzhi Wang Liang Chang Yiqun Ren Manshu Sui Yuting Fu Lei Zhang Lirong Hao Source Type: research
Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study
CONCLUSIONS: Patients with ICI-AKI were more likely to have impaired renal function at baseline and after treatment with antibiotics. Approximately half of the patients achieved renal recovery.PMID:38466161 | DOI:10.1080/0886022X.2024.2326186 (Source: Renal Failure)
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Ping Zhou Bing Liu Ning Shen Xiaoting Fan Shangwei Lu Zhijuan Kong Ying Gao Zhimei Lv Rong Wang Source Type: research
What came first, atypical hemolytic uremic syndrome or malignant hypertension: a clinical dilemma
Ren Fail. 2024 Dec;46(1):2327484. doi: 10.1080/0886022X.2024.2327484. Epub 2024 Mar 11.NO ABSTRACTPMID:38466192 | DOI:10.1080/0886022X.2024.2327484 (Source: Renal Failure)
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Sidharth Kumar Sethi Savita S Aishwarya Nair Kritika Soni Shyam Bihari Bansal Abhyuday S Rana Rupesh Raina Source Type: research
Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review
Ren Fail. 2024 Dec;46(1):2323160. doi: 10.1080/0886022X.2024.2323160. Epub 2024 Mar 11.ABSTRACTAnti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output. A renal biopsy revealed crescent glomerulonephritis with linea...
Source: Renal Failure - March 11, 2024 Category: Urology & Nephrology Authors: Zewei Chen Dechao Xu Fangzheng Cui Huihui Hou Zhiguo Mao Xiang Gao Source Type: research
