The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients
CONCLUSION: Elevated PDW is independently associated with all-cause and cardiovascular mortality in PD patients.PMID:38343320 | PMC:PMC10863511 | DOI:10.1080/0886022X.2023.2300730 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Chunyu Lu Shuiqin Cheng Wenjing Fan Zhihong Zhang Jinquan Wang Source Type: research
Diagnostic value of multi-parameter ultrasound evaluation in sepsis complicated by acute kidney injury
CONCLUSION: High RI values increase the risk of sepsis-induced AKI, whereas low MPUS may reduce it. RI showed high diagnosis values for sepsis complicated with AKI.PMID:38344995 | PMC:PMC10863507 | DOI:10.1080/0886022X.2024.2313861 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Liu Wang Xiang Wang Source Type: research
The role of computed tomography in the diagnosis of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis
Ren Fail. 2024 Dec;46(1):2312214. doi: 10.1080/0886022X.2024.2312214. Epub 2024 Feb 12.NO ABSTRACTPMID:38344999 | PMC:PMC10863510 | DOI:10.1080/0886022X.2024.2312214 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Aomei Li Longkai Li Fujia Guo Dan Zhou Wei Yang Wengting Cui Shuran Wu Lin Li Changqing Yu Hongli Lin Source Type: research
Assessment of urine CCL2 as a potential diagnostic biomarker for acute kidney injury and septic acute kidney injury in intensive care unit patients
In this study, we investigated the potential of plasma and urine CCL2 levels as diagnostic markers for AKI and SAKI in 216 ICU patients. Our findings revealed significant differences in plasma (p < 0.01) and urine CCL2 (p < 0.0001) levels between AKI and non-AKI patients in the ICU. Notably, urine CCL2 demonstrated promising predictive value for AKI, exhibiting high specificity and sensitivity (AUC = 0.8976; p < 0.0001). Furthermore, we observed higher urine CCL2 levels in SAKI compared to non-septic AKI (p < 0.001) and urine CCL2 could also differentiate SAKI from non-septic AKI (AUC = 0.7597; p < 0.0001). ...
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Yuan Peng Qin Wang Fang Jin Tao Tao Qihong Qin Source Type: research
Ultra-processed food consumption and the risk of incident chronic kidney disease: a systematic review and meta-analysis of cohort studies
CONCLUSIONS: High-dose UPF intake was associated with an increased risk of incident CKD. However, the underlying mechanisms remain unknown. Thus, more standardized clinical studies and further exploration of the mechanisms are needed in the future.PMID:38345016 | PMC:PMC10863522 | DOI:10.1080/0886022X.2024.2306224 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Bingjie Xiao Jinxian Huang Linyi Chen Yujie Lin Jianghong Luo Huifen Chen Lizhe Fu Fang Tang Wenwei Ouyang Yifan Wu Source Type: research
Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients
CONCLUSION: Our results have shown that in KT patients, despite the recovery of kidney function, the TAC reduced but did not normalize oxidative stress levels in long-term therapy, and the TAC effect significantly depends on the concentration used.PMID:38345031 | PMC:PMC10863538 | DOI:10.1080/0886022X.2024.2313863 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Mariam Ammar Soumaya Yaich Ahmed Hakim Hanen Ghozzi Zouheir Sahnoun Mohamed Ben Hmida Khaled Zghal Lobna Ben Mahmoud Source Type: research
Comparison of the Watson formula and bioimpedance spectroscopy for measuring body volume and calculating kt/V in patients with peritoneal dialysis
Ren Fail. 2024 Dec;46(1):2313360. doi: 10.1080/0886022X.2024.2313360. Epub 2024 Feb 12.ABSTRACTThere were significant differences between Vwat and Vbis and between Kt/Vwat and Kt/Vbis. Kt/Vwat may underestimate small-solute dialysis adequacy in most cases. Kt/Vbis instead of Kt/Vwat could be accounted for in creating individualized dialysis prescriptions if the patient has no obvious clinical symptoms.PMID:38345032 | PMC:PMC10863529 | DOI:10.1080/0886022X.2024.2313360 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Sixiu Liu Yuan Feng Qingyan Zhang Jian Lu Nan Li Ying Liu Chunming Jiang Source Type: research
Kr üppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition
This study tested the hypothesis that the Krüppel-like factor 4 (KLF4)/miR-101/Collagen alpha-1X (COL10A1) axis could inhibit epithelial-mesenchymal transition (EMT) and renal fibrosis after AKI in a mouse model of ischemia-reperfusion (I/R)-induced renal fibrosis and HK-2 cells by gene silencing, overexpression, immunofluorescence, immunohistochemistry, real-time quantitative PCR, Western blotting, dual-luciferase reporter assay, fluorescence in situ hybridization (FISH) and ELISA. Compared with the Sham group, I/R induced renal tubular and glomerular injury and fibrosis, and increased the levels of BUN, serum Scr and ne...
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Jingying Zhao Xiuli Wang Yubin Wu Chengguang Zhao Source Type: research
Cardiovascular and renal safety outcomes of hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat for anemia patients with chronic kidney disease: a systematic review and meta-analysis
Ren Fail. 2024 Dec;46(1):2313864. doi: 10.1080/0886022X.2024.2313864. Epub 2024 Feb 12.ABSTRACTThis systematic review and meta-analysis were conducted to evaluate the cardiac and kidney-related adverse effects of roxadustat for the treatment of anemia in CKD patients. 18 trials with a total of 8806 participants were identified for analysis. We employed a fixed-effects model for analysis. The pooled result revealed no significant difference in the risk of occurrence of cardiac disorders when comparing CKD patients receiving roxadustat with the placebo (RR = 1.049; CI [0.918 to 1.200]) or ESA (RR = 1.066; CI [0.919 to 1.235]...
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Lei Tian Mengdi Wang Mengchao Liu Yanyu Pang Jingwen Zhao Bingjie Zheng Yutong Wang Wenjing Zhao Source Type: research
Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023
This study uses the bibliometric method to identify the evolutionary development and recent hotspots of hypertensive nephropathy. The Web of Science Core Collection database was used to extract publications on hypertensive nephropathy from January 2000 to November 2023. CiteSpace was used to capture the patterns and trends from multi-perspectives, including countries/regions, institutions, keywords, and references. In total, 557 publications on hypertensive nephropathy were eligible for inclusion. China (n = 208, 37.34%) was the most influential contributor among all the countries. Veterans Health Administration (n = 19, 3...
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Lan Wang Jingyu Wang Yuemiao Zhang Hong Zhang Source Type: research
Impact of electronic AKI alert/care bundle on AKI inpatient outcomes: a retrospective single-center cohort study
CONCLUSIONS: AKI order set use led to improvements in all-cause mortality and renal function, but longer LOS, among AKI patients at WSH.PMID:38345055 | PMC:PMC10863540 | DOI:10.1080/0886022X.2024.2313177 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Michael Chen-Xu Christopher Kassam Emma Cameron Szymon Ryba Vivian Yiu Source Type: research
Elevated ALOX12 in renal tissue predicts progression in diabetic kidney disease
This study aims to identify the main differentially expressed genes in DKD from transcriptome sequencing results and analyze their diagnostic value. The present study sequenced db/m mouse and db/db mouse to determine the ALOX12 genetic changes related to DKD. After preliminary validation, ALOX12 levels were significantly elevated in the blood of DKD patients, but not during disease progression. Moreover, urine ALOX12 was increased only in macroalbuminuria patients. Therefore, to visualize the diagnostic efficacy of ALOX12 on the onset and progression of renal injury in DKD, we collected kidney tissue from patients for immu...
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Meixi Wang Jingjing Wang Jinni Wang Yonggui Wu Xiangming Qi Source Type: research
Influencing factors of clinical efficacy of roxadustat among hemodialysis patients
CONCLUSIONS: Age, blood trough concentration of roxadustat, and baseline Hb level were independent influencing factors of the response to roxadustat in hemodialysis patients.PMID:38345059 | PMC:PMC10863536 | DOI:10.1080/0886022X.2024.2308701 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Wenhui Wu Nan Hu Xiurong Li Jia Di Hua Zhou Hongyan Niu Min Yang Source Type: research
Value of original and modified pathological scoring systems for prognostic prediction in paraffin-embedded donor kidney core biopsy
CONCLUSIONS: Scoring systems could predict allograft prognosis in paraffin-embedded CB with ten more glomeruli. A simple and pragmatic scoring system should include GS, IF, TA and AH, with weights assigned based on predictive capacity for prognosis. Replacing GS scores with tubulointerstitial scores could significantly improve the predictive capacity of eGFR. The conclusion should be further validated in frozen section.PMID:38345067 | PMC:PMC10863519 | DOI:10.1080/0886022X.2024.2314630 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Jinghong Tan Huanxi Zhang Longshan Liu Jun Li Qian Fu Yan Li Chenglin Wu Ronghai Deng Jiali Wang Bowen Xu Wenfang Chen Shicong Yang Changxi Wang Source Type: research
External Validation of the International Prognosis Prediction Model of IgA Nephropathy
CONCLUSIONS: Both prognostic risk evaluation models for IgAN exhibited remarkable discrimination, sound calibration, and acceptable clinical utility.PMID:38345077 | PMC:PMC10863512 | DOI:10.1080/0886022X.2024.2313174 (Source: Renal Failure)
Source: Renal Failure - February 12, 2024 Category: Urology & Nephrology Authors: Lichao Hu Yi Fang Jiaxin Huang Jin Liu Lingling Xu Weichun He Source Type: research
