Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure.
CONCLUSION: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients. PMID: 27764985 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Helicobacter pylori participates in the pathogenesis of IgA nephropathy.
This study aimed to investigate the risk incidence of IgAN caused by Hp infection. 22 primary IgAN, 20 non-IgA nephropathy (n-IgAN), and 30 healthy controls were included in this study. We found that the rate of IgG anti-Hp seropositivity was significantly improved in IgAN, but the current Hp infection was similar in all groups. The production and underglycosylation of IgA1 tended to increase in IgAN patients with IgG anti-Hp seropositivity. A tendency toward increased the risk of clinical prognosis was seen in IgAN with Hp infection. Hp antigen and CagA were only deposited in renal tubules, and enhanced antigen deposition...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies.
CONCLUSIONS: Our meta-analysis suggested that more than one-quarter of CKD sufferers, especially those who were on dialysis, were plagued by RLS. Higher sensitivity of diagnostic criteria in interview may be valuable for timely treatment. PMID: 27765002 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of hyperbaric oxygen therapy on rhabdomyolysis-induced myoglobinuric acute renal failure in rats.
Authors: Cebi G, Yildiz Ş, Uzun G, Oztas Y, Sabuncuoglu S, Kutlu A, Ilgaz Y, Karatop-Cesur I, Dogan E, Oztas E Abstract Myoglobinuric acute renal failure (MARF) may develop after severe muscle injury. Heme oxygenase-1 (HO-1), a stress-response protein, has been implicated as a protective agent against MARF. We hypothesized that hyperbaric oxygen therapy (HBOT) may alleviate MARF by inducing renal HO-1 expression. Wistar-Albino rats were randomly assigned into three groups: Control (n = 4), MARF (n = 8), MARF + HBO (n = 8). MARF was induced by intramuscular gl...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Etiology, clinical profile and short-term outcome of acute kidney injury in children at a tertiary care pediatric nephrology center in Pakistan.
Authors: Tresa V, Yaseen A, Lanewala AA, Hashmi S, Khatri S, Ali I, Mubarak M Abstract BACKGROUND: The reported prevalence rates and etiologies of acute kidney injury (AKI) are quite variable in different regions of the world. The current study was planned to determine the etiology, clinical profile, and short-term outcome of pediatric AKI at our hospital. METHODS: A prospective, observational study was carried out from April 2014 to March 2015. All pediatric patients (1 month to ≤15 years) diagnosed as AKI using modified pRIFLE criteria were studied and followed for 3 months to document short-term ou...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urinary l-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy.
CONCLUSIONS: l-FABP is a suitable urinary biomarker for predicting the extent of ischemic renal injury. PMID: 27767358 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis.
Authors: Soni H, Adebiyi A Abstract Apoptosis of renal tubular and glomerular cells during kidney disease involves activation of Fas ligand (FasL)-dependent death pathway. The significance of FasL in neonates with septic acute kidney injury (AKI) is unresolved, but an increase in renal FasL production, and/or infiltration of circulating FasL into the kidneys may occur following initial septic insult. Here, we examined whether soluble Fas ligand (sFasL) levels are altered during early phase of septic AKI in neonates. Six hours of polymicrobial sepsis elicited by cecal ligation and puncture (CLP) elevated serum C-rea...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Transapical versus transfemoral approach and risk of acute kidney injury following transcatheter aortic valve replacement: a propensity-adjusted analysis.
Authors: Thongprayoon C, Cheungpasitporn W, Srivali N, Harrison AM, Kittanamongkolchai W, Greason KL, Kashani KB Abstract BACKGROUND: The aim of this study was to compare the incidence of post-procedural acute kidney injury (AKI) and other renal outcomes in patients undergoing transapical (TA) and transfemoral (TF) approaches for transcatheter aortic valve replacement (TAVR). METHODS: All consecutive adult patients undergoing TAVR for aortic stenosis from 1 January 2008 to 30 June 2014 at a tertiary referral hospital were included. AKI was defined based on Kidney Disease Improving Global Outcomes (KDIGO) criter...
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients.
CONCLUSIONS: Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients. PMID: 27767372 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 23, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of serum and urinary carbohydrate antigen 19-9 in predicting renal injury associated with ureteral stone.
This study was designed to evaluate the role of urinary and serum carbohydrate antigen 19-9 (CA19-9) as a biomarker in the assessment of patients with ureteral stone. A total of 38 patients with ureteral stone and hydronephrosis who underwent transurethral lithotripsy (TUL) (Group A) and 24 age-matched healthy controls (Group B) were evaluated in this study. Urinary and serum CA19-9 concentrations were measured in group A patients before TUL as well as 4 and 8 weeks following the operation. Urinary and serum CA19-9 concentrations were also measured in group B participants. Median concentration of urinary and serum CA19-9 w...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Relationship between hepatitis B virus infection and chronic kidney disease in Asian populations: a meta-analysis.
Authors: Cai QC, Zhao SQ, Shi TD, Ren H Abstract PURPOSE: To evaluate the association of Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD). METHODS: We searched Embase, Grateful Med, Ovid, PubMed, and the China Biological Medicine Database. A meta-analysis was performed to assess whether HBV infection plays an independent impact on the development of CKD in the general population. Relative risks of CKD (defined as reduced glomerular filtration rate or proteinuria) according to HBsAg serologic status were studied. RESULTS: Six eligible clinical studies (189,709 individuals in total) ...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Silencing HIF-1 α aggravates growth inhibition and necrosis of proximal renal tubular epithelial cell under hypoxia.
In conclusion, silencing HIF-1α gene could aggravate growth inhibition and necrosis of PTEC under hypoxia. We provide evidence, from the opposite direction, that HIF-1 activation under hypoxia may facilitate adaptation and survival of proximal renal tubular cells, and the beneficial effects may be related to its downstream genes, such as Glut-1 and VEGF. PMID: 27756181 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The characteristics and mortality risk factors for acute kidney injury in different age groups in China-a cross sectional study.
CONCLUSION: The characteristics and mortality factors for AKI vary by age in China. Elderly patients were the primary population with AKI, and the most common type of AKI was pre-renal AKI. Special caution should be taken to the old population in hospitalized patients to prevent the pre-renal AKI. PMID: 27756185 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Endocan and albuminuria in type 2 diabetes mellitus.
CONCLUSION: Patients with macroalbuminuria had lower endocan levels, and increasing UACR was associated with decreasing serum endocan levels. Despite the occurrence of angiogenesis and glomerular hypertrophy in the early phase of diabetic nephropathy, ensuing significant renal injury over time may reduce the expression of endocan. Serum endocan levels may represent a novel marker for nephropathy progression. PMID: 27756187 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Fasudil inhibits tissue factor and plasminogen activator Inhibitor-1 secretion by peripheral blood mononuclear cells in CAPD patients.
Authors: Li W, Chen W, Xie M, Huang H, Su H, Han H, Zhang D, Zhang Y, Yang X, Xu W, Su Y, Wu W, Huang Y, Fu K, Wei J Abstract Disturbances in hemostasis are common complications of kidney diseases and correlate well with cardiovascular mortality. Little is known about the effects of fasudil on tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) expression in peripheral blood mononuclear cells (PBMCs) in CAPD patients. PBMCs were isolated from 13 individuals with CAPD and 13 healthy subjects. After 4 h of incubation with or without LPS (10 ng/mL), TF and PAI-1 mRNA of PBMCs were detected b...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of weight-based vancomycin dosing for hospitalized hemodialysis patients.
CONCLUSION: Simplifying and standardizing vancomycin dosing for hospitalized IHD patients based on weight resulted in 37% of patients achieving goal pre-IHD vancomycin level of 15-20 mg/L with zero patients having a pre-IHD vancomycin level
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF- β1, and collagen-1.
Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-β1, and collagen-1. Ren Fail. 2016 Oct 19;:1-13 Authors: Sadar S, Kaspate D, Vyawahare N Abstract Diabetic nephropathy is a serious microvascular complication and one of the main causes of end-stage renal disease. L-Glutamine (LG) is naturally occurring amino acids with antidiabetic and antioxidant potential. The aim of present investigation was to evaluate the potential of LG against streptozotocin (STZ)-induced diabetic nephropathy (DN) in laboratory rats. DN was induced in male...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Kidney injury molecule-1 in kidney disease.
Authors: Yin C, Wang N Abstract Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome....
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Uremic toxins: some thoughts on acrolein and spermine.
Authors: Sindhu KK Abstract Chronic kidney disease (CKD) is characterized by the progressive reduction of glomerular filtration rate and subsequent retention of organic waste compounds called uremic toxins. While patients with CKD are at a higher risk of premature death due to cardiovascular complications, this increased risk cannot be completely explained by classical cardiovascular risk factors such as hypertension, diabetes mellitus, and obesity. Instead, recent research suggests that uremic toxins may play a key role in explaining this marked increase in cardiovascular mortality in patients with CKD. While sper...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Medical student attitudes toward kidney physiology and nephrology: a qualitative study.
Authors: Roberts JK, Sparks MA, Lehrich RW Abstract Interest in nephrology among trainees is waning in the USA. Early perceptions and attitudes to subject matter can be linked to the quality of pre-clinical curricula. We wanted to explore these attitudes in the setting of modern curriculum redesign. We utilized Q methodology to understand first-year medical student attitudes after an innovative kidney physiology curriculum redesign that focuses on blending multiple learning methods. First-year medical students were invited to take a Q sort survey at the conclusion of a kidney physiology course. Students prioritized...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Community-based study on elderly CKD subjects and the associated risk factors.
CONCLUSIONS: The prevalence of CKD is high in the elderly population than that of adult CKD in Shanghai. The most risk factors for elderly CKD patients are similar to the adult population. But hypercholesterolemia as a risk fact of elderly CKD is different from adult CKD. PMID: 27758130 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical significance of different carnitine levels for improving the prognosis of patients undergoing hemodialysis.
Authors: Zhang YM, Zhuo L, Hu J, Cui G, Zhang L, Zhang XL, Li WG Abstract OBJECTIVE: To investigate plasma-free carnitine (Fc), acylcarnitine (Ac), and total carnitine (Tc) levels in patients undergoing hemodialysis (HD), and to explore their clinical significance. METHODS: A total of 20 subjects were in the normal control group and 133 patients undergoing HD were divided into medicated (received carnitine treatment) and non-medicated groups. The medicated group was further divided into three subgroups according to Fc level: Fc = 80-199, 200-299, and ≥ 300 μmol/L. We use...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis.
In this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), IL-6, IL-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (MDA) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, Fas, and Fas ligand (Fas-L)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). In a conclu...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients.
Authors: Wang Z, Wen Y, Liang J, Liang X, Shi W Abstract Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV diastolic function has not been clear. The aim of this study was to investigate the influence of low calcium dialysate on cardiac function in peritoneal dialysis (PD) patients. A total of 60 PD patients were enrolled in this study, with a calcium ...
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion.
CONCLUSION: We, for the first time in the literature, showed that miR-320 is increased in IR injury. miR-320 might be a novel diagnosis and treatment target in renal ischemic reperfusion injury. Also, for the first time, we showed that CAP and TEL cause functional and histopathological recovery and lower miR-146a and miR-320. PMID: 27760486 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Letter to the editor regarding the article "Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis".
Letter to the editor regarding the article "Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis". Ren Fail. 2016 Oct 17;:1 Authors: Besiroglu H, Kadihasanoglu M, Ozbek E PMID: 27748147 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Personality traits and clinical/biochemical course in the first year after kidney transplant.
CONCLUSION: In this study, patients from Cluster 2 exhibited higher eGFR 9 months after the transplant procedure compared to those from Cluster 1. Monitoring these patients over a longer period may provide a better understanding of the relationship between personality traits and clinical course during the post-transplant period. PMID: 27686135 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - October 2, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Metformin-related lactic acidosis: is it a myth or an underestimated reality?
Authors: Visconti L, Cernaro V, Ferrara D, Costantino G, Aloisi C, Amico L, Chirico V, Santoro D, Noto A, David A, Buemi M, Lacquaniti A Abstract Metformin, belonging to a class of drugs called biguanides, is the recommended first-line treatment for overweight patients with type 2 diabetes mellitus. It has multiple mechanisms of action, such as reduction of gluconeogenesis, increases peripheral uptake of glucose, and decreases fatty acid oxidation. However, a potential serious complication, defined metformin-associated lactic acidosis (MALA), is related to increased plasma lactate levels, linked to an elevated plas...
Source: Renal Failure - October 2, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of Silodosin as a new medical expulsive therapy for ureteral stones: a meta-analysis.
Authors: Ding H, Ning Z, Dai Y, Shang P, Yang L Abstract To evaluate the efficacy of Silodosin as a medical expulsive therapy of ureteral stones, we searched PubMed, EMBASE, the Cochrane Library, and CBM up to June 2015. All randomized controlled trials (RCTs) were identified in which patients were randomized to receive Silodosin versus placebo or other therapies for ureteral stones. Outcome measures assessed were overall stone expulsion rate (primary) and expulsion time, analgesics times, and the incidence of additional treatment and regarding treatment complications (secondary). Two authors independently assessed...
Source: Renal Failure - October 2, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.
CONCLUSIONS: Our data indicate that AGM has a protective effect against cisplatin-induced nephrotoxicity. Therefore, it may improve the therapeutic index of cisplatin. In addition, the early renal damage induced by cisplatin and protective effects of AGM against cisplatin nephrotoxicity was accurately demonstrated with 99mTc-DMSA renal scintigraphy. PMID: 27604130 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - September 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Alterations in morphology and hepatorenal indices in rats subacutely exposed to bitumen extract.
In this study, bitumen obtained from a seepage source in Agbabu, the town of first discovery, was used in sub-acute toxicity studies in a rat experimental model, in order to assess potential health risks posed to local populace sequel to full exploitation of bitumen. Dosages were chosen to accommodate low to high cases of environmental exposures. Male Wistar rats were administered, per os, dosages of bitumen extract at 5, 3, 2, and 1 mg/kg body weight. Following euthanasia 28 days later, histological findings revealed severe portal congestion and cellular infiltration in the liver, while in the kidney there were pro...
Source: Renal Failure - September 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Amelioration of cisplatin-induced acute kidney injury by recombinant neutrophil gelatinase-associated lipocalin.
Authors: Ma Q, Devarajan SR, Devarajan P Abstract We investigated the protective effect and mechanism of neutrophil gelatinase-associated lipocalin (NGAL) in a murine model of cisplatin-induced nephrotoxicity. Male Swiss-Webster mice were assigned to four groups (n = 10 in each group). Control mice received vehicle only. Mice in the experimental group were given a single intraperitoneal injection of cisplatin (20 mg/kg) to induce nephrotoxicity, and were divided into three groups. The first group received 100 μL of saline only via tail vein at the time of cisplatin administration. The...
Source: Renal Failure - September 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of mutant lactobacilli on serum creatinine and urea nitrogen concentrations and renal pathology in 5/6 nephrectomized rats.
Authors: Wang F, Jiang YS, Liu F Abstract OBJECTIVES: To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS: Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model group, a wide-type Lactobacilli group (L.B group), and a Mutant Lactobacilli group (Mut-L.B group). The rats in the Model, LB and Mut-L.B groups underwent 5/6 nephrectomy. Eight weeks after administration, 24-h urine, orbital blood and digestive secretions...
Source: Renal Failure - September 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical outcomes with a systolic blood pressure lower than 120  mmHg in older patients with high disease burden.
Clinical outcomes with a systolic blood pressure lower than 120 mmHg in older patients with high disease burden. Ren Fail. 2016 Sep 8;:1-6 Authors: Franco Palacios CR, Haugen EN, Thompson AM, Rasmussen RW, Goracke N, Goyal P Abstract BACKGROUND: The target blood pressure in older patients is controversial. Recent studies provided clinical evidence supporting a target systolic blood pressure 50 years at high risk of cardiovascular events. METHODS: Retrospective study of 380 consecutive patients ≥60 years with stages 1-5 pre-dialysis chronic kidney disease seen between January 2013 and Nove...
Source: Renal Failure - September 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Health related quality of life in 2002 and 2015 in patients undergoing hemodialysis: a single center study.
Authors: Knudsen Sde P, Eidemak I, Molsted S Abstract Health related quality of life (HRQOL) has become a recognized outcome in studies of the treatment of patients undergoing hemodialysis (HD). The aim of this study was to assess changes in HRQOL reported by two different samples of patients undergoing HD in the same dialysis center in 2002 and 2015. Two samples of patients from the same Danish dialysis center completed the HRQOL questionnaire Kidney Disease Quality of Life version 1.3 in 2002 (n = 71) and 2015 (n = 81), respectively. The associations between KDQOL summery scores and th...
Source: Renal Failure - September 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urinary kidney injury molecules in children with febrile seizures.
Authors: Güneş A, Ece A, Akça H, Aktar F, Mete Ş, Samanci S, Uluca Ü, Şen V, Tan İ, Kaplan İ Abstract OBJECTIVE: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time. METHODS: The study included 28 children with FS and 34 age and gender matched hea...
Source: Renal Failure - August 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinical and pathological analysis of IgA nephropathy with chronic renal failure.
CONCLUSION: IgA nephropathy with chronic renal failure usually occurred in young adults, and it had severe clinical condition and pathological changes, while there was no significant relationship between them. PMID: 27558026 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - August 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association between GSTM1, GSTT1, and GSTP1 variants and the risk of end stage renal disease.
Authors: Nomani H, Hagh-Nazari L, Aidy A, Vaisi-Raygani A, Kiani A, Rahimi Z, Bahrehmand F, Shakiba E, Mozaffari HR, Tavilani H, Pourmotabbed T Abstract INTRODUCTION: There are some evidences indicating DNA damage by oxidant and mutant agents has an essential role in the chronic renal failure and end stage renal disease (ESRD). To investigate the possible association of GSTs variants with ESRD, we investigated the frequency of GST- T1, M1, and P1 genotypes, and the level of malondialdehyde (MDA) in patients with ESRD. MATERIALS AND METHODS: The present case-control study consisted of 136 ESRD patients treated w...
Source: Renal Failure - August 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of angiotensin-converting enzyme insertion/deletion polymorphism with type 1 diabetic nephropathy: a meta-analysis.
This study aimed to systematically evaluate the effect of an angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism on type 1 diabetic nephropathy (DN). METHODS: Cochrane Library, Embase, PubMed, Science Direct, Web of science, Wanfang data, VIP database, China Knowledge Resource Integrated Database, and SinoMed were searched. A total of 17 case-control studies analyzing ACE I/D polymorphism and type 1 DN risk were included in the present meta-analysis. RESULTS: Overall, a significant increased risk was found in allele comparison (OR = 1.16, 95% CI = 1.05-1.28, p&...
Source: Renal Failure - August 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis.
High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis. Ren Fail. 2016 Aug 8;:1-7 Authors: Chimenz R, Lacquaniti A, Colavita L, Chirico V, Fede C, Buemi M, Fede C Abstract BACKGROUND: Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role as precocious marker of peritoneum damage du...
Source: Renal Failure - August 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

18 β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants. Ren Fail. 2016 Aug 8;:1-12 Authors: Abd El-Twab SM, Hozayen WG, Hussein OE, Mahmoud AM Abstract OBJECTIVES: 18β-glycyrrhetinic acid (18β-GA) has multiple beneficial and therapeutic effects. However, its protective roles on methotrexate (MTX)-induced renal injury are not well defined. In the present study, we investigated the possible protective effects of 18β-GA against MTX-induced nephrotoxicity in rats. MATERIALS: 18β-GA (50 a...
Source: Renal Failure - August 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ischemic post-conditioning attenuates renal ischemic reperfusion injury via down-regulation of toll-like receptor 4 in diabetic rats.
CONCLUSION: Taken together, our results suggest that proper IPO may have protective effect on the ischemic injury mediated by renal I/R, which might be associated with inhibition of TLR4 signaling pathway in diabetic rats. PMID: 27494109 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - August 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Non-steroidal anti-inflammatories and the development of analgesic nephropathy: a systematic review.
CONCLUSION: A relationship between non-steroidal anti-inflammatory medicines and the development of CKD has never been proven. Based on the available scientific evidence non-steroidal anti-inflammatory agents do not appear to be implicated in the pathogenesis of AN. PMID: 27494231 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - August 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Community-acquired hyperkalemia in elderly patients: risk factors and clinical outcomes.
This study was performed to investigate the risk of CAH in elderly and evaluate the related factors and clinical outcomes. Study design, setting and participants, intervention: Patients (aged ≥65 years) with hyperkalemia were screened. Group 1 (young-old); 65-74 years/old, Group 2 (middle-old); 75-84 years/old, Group 3 (oldest-old); ≥85 years/old, and Group 4 (control group); ≥65 years/old (normal serum potassium levels). The relation between CAH and hospital expenses (HE), the number of comorbid diseases (NCD), and all-cause of mortality rates (MR) were evaluated. We also investigated whether drugs, sex, and NCD ...
Source: Renal Failure - August 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Active CMV and EBV infections in renal transplant recipients with unexplained fever and elevated serum creatinine.
Authors: Hasannia T, Moosavi Movahed SM, Vakili R, Rafatpanah H, Hekmat R, Valizadeh N, Rezaee SA Abstract Proper identification of active cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are helpful for monitoring antiviral treatment in transplant recipients. Qualitative and quantitative CMV, EBV DNA PCR techniques in the context of serological tests are performed for early detection and differentiation of active and latent CMV and EBV infections in renal transplantation. Basically, 129 renal transplanted recipients monitored carefully and hospitalized for unexplained elevated creatinine levels or hig...
Source: Renal Failure - August 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal ischemia/reperfusion against nephrectomy for induction of acute lung injury in rats.
CONCLUSION: Acutely accumulated systemic mediators following renal failure in the absence of kidneys vary from those due to combined renal failure with ischemic-reperfused kidneys and consequently they induce ALI with distinct characteristics. PMID: 27484785 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - August 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats.
CONCLUSION: It is concluded that NMDA receptor antagonism significantly contributes towards curcumin-mediated protection against I/R-induced AKI. PMID: 27484883 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - August 5, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A novel factor for primary arteriovenous fistula failure: hyperinsulinism.
DISCUSSION: Insulin resistance or hyperinsulinism may be a significant cause of pAVFF, which emphasizes the role of endothelium in fistula dysfunction. PMID: 27466042 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - July 30, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum indoleamine 2,3 dioxygenase and tryptophan and kynurenine ratio using the UPLC-MS/MS method, in patients undergoing peritoneal dialysis, hemodialysis, and kidney transplantation.
This study investigated the level and activity of IDO and determined oxidative balance by calculating the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). We enrolled 60 kidney disease patients, including 20 on peritoneal dialysis (PD group), 19 on hemodialysis (HD group), and 21 with kidney transplantation (KT group), as well as 21 control group. RESULTS: IDO levels were increased in the PD, HD, and KT groups compared to the control group. The concentration of kynurenine was significantly increased in the PD group compared to the other groups (p 
Source: Renal Failure - July 30, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal functional reserve and renal hemodynamics in hypertensive patients.
Authors: Gaipov A, Solak Y, Zhampeissov N, Dzholdasbekova A, Popova N, Molnar MZ, Tuganbekova S, Iskandirova E Abstract The renal functional reserve (RFR) is the ability of the kidneys to increase renal plasma flow and glomerular filtration rate (GFR) in response to protein intake. It is a measure of functional and anatomic integrity of nephrons. It is not known what relation between RFR and kidney Doppler parameters. We aimed to study the relation between the RFR and renal hemodynamic parameters in hypertensive patients with and without nephropathy who had normal kidney function. Twenty-four hypertensive subjects ...
Source: Renal Failure - July 30, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research