The effect of hemodialysis on ocular changes in patients with the end-stage renal disease.
Conclusion: Hemodialysis can affect various ocular parameters including SFCT, RAC and RVC, which changed significantly following hemodialysis. Whereas BCVA, IOP and CMT did not change after hemodialysis in ESRD patients. The systemic compensatory mechanisms of the changes in SBP, DBP, body weight following hemodialysis need further study. PMID: 31269848 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of prophylactic use of low molecular weight heparin or aspirin in thromboembolic events in primary membranous nephropathy.
Conclusions: The prophylactic use of LMWH showed no benefits on the incidence of ATEs or VTEs in patients with PMN. Aspirin effectively decreased the incidence of VTEs, without effects on the occurrence of ATEs. PMID: 31269849 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - July 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of oxidative stress-mediated apoptosis in the pathogenesis of uric acid nephropathy.
Authors: Yang L, Chang B, Guo Y, Wu X, Liu L Abstract Objective: By copying the uric acid nephropathy rat model, the oxidative stress injury of mitochondria was caused in renal tubular epithelial cells and the relationship between the injury and the induction of cell apoptosis was identified. Methods: All rats were randomly divided into NC (normal control, NC) group, HUA (high uric acid, HUA) group and GSH (reductive glutathione, GSH) group. The values were quantitatively tested in the kidney tissues, including 24-h urinary protein quantity, serum creatinine, blood uric acid, the MDA (malondialdehyde, MDA) and SOD ...
Source: Renal Failure - July 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Triterpene derivative improves the renal function of streptozotocin-induced diabetic rats: a follow-up study on maslinic acid.
Conclusions: PH-MA is, therefore, a promising multitarget antidiabetic agent that may ameliorate kidney function of diabetic patients at a dose four times lower than the parent compound (MA). PMID: 31234683 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services.
Authors: Garcia-Canton C, Rodenas A, Lopez-Aperador C, Rivero Y, Anton G, Monzon T, Diaz N, Vega N, Loro JF, Santana A, Esparza N Abstract Background: Frailty is an aging-associated state of increased vulnerability, which raises the risk of adverse outcomes. Chronic kidney disease is associated with higher prevalence of frailty. Our aim was to estimate frailty prevalence in a hemodialysis population and its influence on short-term outcomes. Design: Observational prospective longitudinal study of 277 prevalent hemodialysis patients. Frailty was estimated through the Edmonton Frail Scale (EFS). Demographic and clinic...
Source: Renal Failure - June 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients.
Authors: Fayed A, El Nokeety MM, Heikal AA, Sadek KM, Hammad H, Abdulazim DO, Salem MM, Sharaf El Din UA, Vascular Calcification Group (VCG) Abstract Low serum 25 hydroxyvitamin D (25 OH D) is common among chronic kidney disease (CKD) patients. This cross-sectional study is looking for the different factors associated with serum 25 OH D among pre-dialysis CKD. 1624 adult stage 3-5 CKD patients were studied beside 200 normal control subjects. All candidates were tested for body mass index (BMI), estimated glomerular filtration rate (eGFR), calcium (Ca), phosphorus (P), parathormone (PTH), 25 OH D, albumin, and uric ...
Source: Renal Failure - June 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

An optimized 5/6 nephrectomy mouse model based on unilateral kidney ligation and its application in renal fibrosis research.
Authors: Tan RZ, Zhong X, Li JC, Zhang YW, Yan Y, Liao Y, Wen D, Diao H, Wang L, Shen HC Abstract 5/6 Nephrectomy (PNx) on rat and mouse mimics renal failure after loss of kidney function in human, and it has been widely used in CKD researches. However, existing methods for PNx model construction present high mortality of animals after modeling due to hemorrhage and infection in or after surgery. Here, we report a novel and highly efficient PNx modeling method to simulate conventional 5/6 nephrectomy, which significantly reduced the mortality of animals and simplified the modeling procedures. In this novel modeling...
Source: Renal Failure - June 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute toxic kidney injury.
Authors: Petejova N, Martinek A, Zadrazil J, Teplan V Abstract Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nephrotoxic substances, may be community acquired with ingestion or inhalation or nosocomial. Many nephrotoxic plants, animal poisons, medications, chemicals and illicit drugs can induce AKI by varying pathophysiological pathways. Moreover, th...
Source: Renal Failure - June 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Relationship between serum bilirubin levels and mortality in patients on peritoneal dialysis.
Conclusions: The baseline serum TBil and IBil levels were significantly associated with 5-year all-cause mortality among PD patients. PMID: 31240974 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 28, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A modified relief of unilateral ureteral obstruction model.
Conclusions: Using the method of reimplantation + catheter, a reliable mice model of RUUO can be got. After RUUO, the de-obstructed kidneys are still in damage and fibrosis state. PMID: 31215300 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 21, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Diagnostic value of neutrophil gelatinase-associated lipocalin in diabetic nephropathy: a meta-analysis.
Conclusions: Our findings suggest that NGAL is a potential diagnostic marker for patients with DN and that its diagnostic value for microalbuminuria + macroalbuminuria is superior to that for microalbuminuria. Highlights The first meta-analysis to investigate NGAL diagnostic role in DN. NGAL is valuable for the early diagnosis of DN. The diagnostic value of NGAL in microalbuminuria + macroalbuminuria was much higher. PMID: 31215304 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 21, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Potential role of estradiol in ovariectomy-induced derangement of renal endocrine functions.
Authors: El-Gendy AA, Elsaed WM, Abdallah HI Abstract Menopause is an important physiological event associated with structural and functional changes in the kidneys. An animal model of bilateral ovariectomy was used to study the effects of estrogen depletion, replacement and antiestrogen on renal structure and endocrine function. Sixty female rats were divided into six groups; group I was the control group, the remaining five groups underwent ovariectomy: group II received no treatment. The other groups received estradiol in group III, tamoxifen in group IV, estradiol followed by tamoxifen in group V and tamoxifen ...
Source: Renal Failure - June 21, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of peritoneal dialysis with hemodialysis on survival of diabetic patients with end-stage kidney disease: a meta-analysis of cohort studies.
Conclusion: ESRD patients with diabetes may benefit more from HD than PD. PMID: 31216914 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 21, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China.
Authors: Chen L, Luodelete M, Dong C, Li B, Zhang W, Nie P, Liu J, Chen X, Luo P Abstract Background: To investigate the pathological spectrum of glomerular disease in patients with renal insufficiency (RI) from 2008 to 2017. Methods and results: We calculated the estimated glomerular filtration rate (eGFR) with the Chronic Kidney Disease Epidemiology Collaboration creatinine (CKD-EPI) equation and defined RI as an eGFR
Source: Renal Failure - June 15, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Deletion of discoidin domain receptor 2 attenuates renal interstitial fibrosis in a murine unilateral ureteral obstruction model.
Conclusion: DDR2 might play an important role in the development of RIF; Calcium dobesilate can affect the expression of DDR2 and improve the renal interstitial fibrosis in mice. PMID: 31169440 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes.
Conclusions: In adults with prolonged T1D duration, older age at diagnosis and lower heart rate variability may be associated with DKD. PMID: 31162987 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The association of overhydration with megafistulas in hemodialysis patients.
Authors: Tapolyai M, Faludi M, Berta K, Forró M, Zsom L, Pethő ÁG, Rosivall L, Fülöp T Abstract Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well understood. Methods: We assessed the pre-dialysis bioimpedance spectroscopy-measured percentage of overhydration (OH%) in 13 prevalent dialysis patients with CEF development and negative ...
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Bedside placement of peritoneal dialysis catheters - a single-center experience from Hungary.
Conclusions: In selected cases, particularly in severe diuretic refractory heart failure, PDC placement placed by a nephrologist is feasible with a low rate of complications even in a low-volume center setting. The catheters we placed were all functioning with only minor complications and PD could be started immediately. PMID: 31162993 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Validation of the full-age spectrum equation in the approximation of glomerular filtration rate in Chinese patients with chronic kidney disease.
Authors: Xie P, Li HL, Huang JM, Wei LG Abstract Introduction: To investigate the validity of the full age spectrum (FAS) equation in determining the glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD) and to compare the performance of FAS equation and the technetium-99m-diethylene triamine pentaacetic acid (Tc-99m-DTPA) renal dynamic imaging method. Methods: The GFR was determined by three methods in the same day: (a) Tc-99m-DTPA dual plasma sample clearance method (mGFR); (b) FAS equation (eGFR1); (c) Tc-99m-DTPA renal dynamic imaging method (eGFR2). The mGFR was used as the ref...
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urine NGAL as an early biomarker for diabetic kidney disease: accumulated evidence from observational studies.
Conclusions: Urine NGAL, as the early diagnostic marker of DKD, might have the high diagnostic value, especially in cohort studies. PMID: 31162999 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Is urinary oxalate inversely correlated with glomerular filtration rate in chronic kidney disease?
Authors: Xue C, Zhou C, Xu J, Zhang L, Yu S PMID: 31163001 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Conclusions: Niban protein is involved in apoptosis regulation in HK-2 cells, and most likely via caspase-dependent pathway. PMID: 31163002 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

FFNT25 ameliorates unilateral ureteral obstruction-induced renal fibrosis.
In this study, we administered FFNT25 to rats following unilateral ureteral obstruction (UUO) to investigate its anti-fibrosis mechanism. Thirty-two Sprague-Dawley rats were randomly divided into four groups: (1) control (normal rats), (2) sham-operated, (3) UUO-operated + vehicle, and (4) UUO-operated + FFNT25. Two weeks after UUO, the rats were gavaged with either FFNT25 (20.6 mg/kg/day) or vehicle for two weeks. Serum, urine, and kidney samples were collected at the end of the study. FFNT25 reduced levels of renal fibrosis and decreased mRNA and protein levels of extracellular matrix (...
Source: Renal Failure - May 31, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High sensitivity Troponin-I levels in asymptomatic hemodialysis patients.
Authors: Tarapan T, Musikatavorn K, Phairatwet P, Takkavatakarn K, Susantitaphong P, Eiam-Ong S, Tiranathanagul K Abstract Reduction in renal clearance and removal by hemodialysis adversely affect the level and utility of high-sensitivity troponin I (hsTnI) for diagnosis of acute myocardial infarction (AMI) in hemodialysis (HD) patients. Furthermore, HD process itself might cause undesirable myocardial injury and enhance post HD hsTnI levels. This comparative cross-sectional study was conducted to compare the hsTnI levels between 100 asymptomatic HD patients and their 107 matched non-chronic kidney disease (CKD) po...
Source: Renal Failure - May 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1.
Authors: Liu Y, Wu Y, Diao Z, Guo W, Liu W Abstract BACKGROUND: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there is an urgent need to identify therapeutic targets to control the progression of cardiovascular disease. Apoptosis of aortic smooth muscle cells can promote cardiovascular disease, but the role of parathyroid hormone (PTH) and sirtuin 1 in the pathophysiology of apoptosis is still unclear. METHODS: Cultured human aortic smooth muscle cells (HASMCs) were stimulated with 10-6, 10-8, or 10-10 mol/L PTH for different days, apoptosis was measured b...
Source: Renal Failure - May 22, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of exercise training on cardiovascular risk factors in kidney transplant recipients: a systematic review and meta-analysis.
Authors: Chen G, Gao L, Li X Abstract BACKGROUND: Whether exercise can improve cardiovascular health in kidney transplant recipients (KTRs) is unclear. Therefore, we performed a systematic review of the effects of exercise on cardiovascular risk factors in this population setting. METHODS: Randomized control trials (RCTs) evaluating the impact of exercise on major clinical outcomes in KTRs were identified by searches in Cochrane CENTRAL, PubMed, EMBASE, OVID and CBM updated to December 2018. The main outcomes of interest were blood pressure, lipid profile, blood glucose level, arterial stiffness, kidney functio...
Source: Renal Failure - May 22, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Factors associated with late presentation of patients with chronic kidney disease in nephrology consultation in Cameroon-a descriptive cross-sectional study.
Authors: Marie Patrice H, Joiven N, Hermine F, Jean Yves B, Folefack François K, Enow Gloria A Abstract BACKGROUND: Late presentation (LP) of chronic kidney disease (CKD) patients to nephrologist is a serious problem worldwide with persistent high prevalence despite known benefits of early nephrology care. OBJECTIVE: Determine the prevalence and factors associated with LP of CKD patients to nephrologists in Cameroon. METHODS: A cross-sectional study from October 2015 to May 2016 at the nephrology units of the Douala General and Laquintinie hospitals, including all consenting incident CKD patients. Da...
Source: Renal Failure - May 22, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of body composition monitoring for assessment of nutritional status in hemodialysis patients.
CONCLUSIONS: LTI is a predictor of mortality, and its predictive power was not affected when FTI, SGA, and hydration status were included in the multivariate analysis. However, SGA may not be adequate to identify patients at a risk of death among Chinese hemodialysis patients. PMID: 31057002 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renal injury in obese children.
Authors: Kawada T PMID: 31057014 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy.
This study aimed to investigate the unique prognostic, clinical, and renal histopathological characteristics of patients with idiopathic membranous nephropathy (IMN) with different levels of proteinuria. METHODS: This retrospective observational study included 190 IMN patients with low levels of proteinuria (low group), 193 IMN patients with medium levels of proteinuria (medium group), and 123 IMN patients with high levels of proteinuria (high group) treated between September 2006 and November 2015. Prognostic and baseline clinical and histopathological data were compared among the three groups. Poor prognostic events ...
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy.
Authors: Liu Y, Zheng J, Jia J, Li H, Hu S, Lin Y, Yan T Abstract BACKGROUND: Recent genomewide association study suggested that the top single-nucleotide polymorphism, rs978056, in HECW1 gene (which encodes HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) associated with the levels of galactose-deficient IgA1 (Gd-IgA1) in IgA nephropathy (IgAN). However, HECW1 expression in IgAN has not yet been examined. METHODS: In the following study, we have enrolled 40 patients with IgAN and 40 healthy controls. The expression level of HECW1, as well as plasma levels of Gd-IgA1 and IgA1, were determined de...
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Cadmium regulates von Willebrand factor and occludin expression in glomerular endothelial cells of mice in a TNF- α-dependent manner.
CONCLUSIONS: These results suggest that TNF-α acts to balance homeostasis of glomerular endothelium after Cd treatments. PMID: 31057027 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy.
CONCLUSION: We found that rapamycin has protective effects in the IgA nephropathy rat model in a dose-dependent manner. In addition, the result of western blot assay suggested that rapamycin may display its therapeutic effects through interfering the AKT-mTOR-p70S6K signaling pathway. PMID: 31057050 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of iodine contrast-induced acute kidney injury via different injection routes using BOLD-MRI.
CONCLUSIONS: The renal injury induced by 1.0 g iodine/kg iodixanol through renal artery injection was more significant than that caused by the same dose of femoral artery and auricular vein injection, while similar to that caused by 2.0 g iodine/kg femoral artery injection. PMID: 31057054 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The incidence of acute kidney injury following cardiac arrest and cardiopulmonary resuscitation in a rat model.
CONCLUSION: The incidence of AKI in rats was high after suffering from CA and CPR, but renal function improved with the prolongation of ROSC time, indicating the ability of the kidney to self-repair. PMID: 31014141 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The association between chronic musculoskeletal pain and clinical outcome in chronic kidney disease patients: a prospective cohort study.
CONCLUSION: The CKD patients with chronic MS pain was independently and significantly associated with all-cause mortality, but not independently and significantly associated with CKD progression and composite endpoints. The inflammatory marker-hs-CRP was similar between CKD patients with and without chronic MS pain. PMID: 31014149 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.
CONCLUSION: Renal function was a strong determinant of NLR in cardiovascular outpatients. NLR elevation due to renal impairment is caused by distortion of the hematopoietic process in bone marrow. IS plays a significant role in these processes. PMID: 31014150 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis.
CONCLUSIONS: The pooled prevalence of CAC is highly prevalent. CAC is independently associated with all-cause and cardiovascular mortality risk as well as cardiovascular events among CKD patients. In view of the high heterogeneity, larger clinical trials are still needed. PMID: 31014155 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Autophagy activity and expression pattern of autophagy-related markers in the podocytes of patients with lupus nephritis: association with pathological classification.
Authors: Jin J, Tu Q, Gong J, Zhao L, Liang S, He Q Abstract OBJECTIVE: To identify the significance of autophagy in lupus nephritis (LN). METHODS: The number of autophagosomes in podocytes was counted and the expression of multiple molecular markers associated with autophagy was evaluated in LN specimens: in renal biopsy specimens from 90 patients with LN and 15 healthy controls, autophagosomes in podocytes were counted using transmission electron microscopy and the expression levels of four autophage related proteins including Beclin-1, microtubule-associated protein light chain 3 (LC3), autophagy-related gen...
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effectiveness of cinacalcet: a randomized, open label study in chronic hemodialysis patients with severe secondary hyperparathyroidism.
CONCLUSIONS: The effectiveness of cinacalcet were still obviously demonstrated even in chronic HD patients with severe SHPT. In addition, the improvements of bone markers and FGF-23, and stabilization of vascular calcification were observed. Therefore, cinacalcet can provide salutary effects on CKD-MBD in severe SHPT and might be an initially effective PTH-lowering therapy prior to surgical parathyroidectomy as well as an alternative treatment in the patients unsuitable for surgery. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov: NCT02056730. Date of registration: February 4, 2014. PMID: 31014177 [PubMed - in proc...
Source: Renal Failure - April 26, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of Staphylococcus nasal colonization and HIV in end-stage renal failure patients undergoing peritoneal dialysis.
This study evaluated the effects of HIV infection on nasal carriage of Staphylococcus aureus, staphylococcal peritonitis, and catheter infection rates in patients with end-stage renal failure managed with continuous ambulatory peritoneal dialysis (CAPD). METHODS: Sixty HIV-positive and 59 HIV-negative CAPD patients were enrolled and followed up for up to 18 months. S. aureus nasal carriage (detected by nasal swab culture), Staphylococcal peritonitis (diagnosed by clinical presentation, and CAPD effluent Staphylococcal culture and white blood cell count ≥100 cells/µL), and catheter infections (including ...
Source: Renal Failure - April 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Authors: Sukkummee W, Jittisak P, Wonganan P, Wittayalertpanya S, Chariyavilaskul P, Leelahavanichkul A Abstract Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in functions of drug-metabolizing enzymes in the liver and functions of intestinal drug transporters. We compared the defect on mouse CYP3A11 (human CYP3A4 representative) in liver and intestine along with several intestinal drug transporters (MDR1a, MRP2, and...
Source: Renal Failure - April 19, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of anti-peritoneal fibrotic effects between an mTORC1-specific blocker and a PI3K/mTOR dual-blocker.
CONCLUSION: RAPA did not up-regulate p-Akt in a negative feedback fashion. Both drugs effectively inhibited peritoneal fibrosis. PMID: 30982374 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 16, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Glomerular expression of matrix metalloproteinases in systemic lupus erythematosus in association with activity index and renal function.
Authors: Adamidis KN, Kopaka ME, Petraki C, Charitaki E, Apostolou T, Christodoulidou C, Nikolopoulou N, Giatromanolaki A, Vargemesis V, Passadakis P Abstract PURPOSE: The aim of this study was to examine the expression of matrix metalloproteinases (MMPs) MMP-1, MMP-2, MMP-3, MMP-9, and their specific tissue inhibitor TIMP-1 in kidney biopsies of patients with lupus nephritis (LN) and to investigate the relationship between MMPs, activity index, and renal function at the time of kidney biopsy. METHODS: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in...
Source: Renal Failure - April 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification.
Authors: Wang C, Tang Y, Wang Y, Li G, Wang L, Li Y Abstract Vascular calcification (VC) is a pathological process characterized by abnormal deposition of calcium phosphate, hydroxyapatite and other mineral substances in the vascular wall. Hyperphosphorus is an important risk factor associated with VC in the general population and patients with chronic kidney disease (CKD). However, there is still a lack of early biomarkers for hyperphosphorus induced VC. We established a calcific rat aorta vascular smooth muscle cells (RASMCs) model by stimulating with β-glycerophosphate. Then we performed label-free quantita...
Source: Renal Failure - April 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China.
Authors: Yang Y, Zhou W, Wang Y, Zhou R Abstract OBJECTIVE: To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference. METHODS: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR)
Source: Renal Failure - April 12, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Renoprotective effect of oral rehydration solution III in exertional heatstroke rats.
CONCLUSION: ORS III could alleviate the kidney injury in EHS rats. PMID: 30942115 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease.
CONCLUSION: The present study demonstrated that a high NLR was associated with poor renal outcomes, suggesting that NLR may be a useful marker for prognostic prediction in patients with CKD. PMID: 30942116 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The influence of glycemic status on the performance of cystatin C for acute kidney injury detection in the critically ill.
CONCLUSION: Glycemic status has no significant impact on the accuracy of sCysC for AKI detection in critically ill adults and a higher optimal cutoff value of sCysC for AKI detection should be considered in diabetic patients. PMID: 30942122 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Incidence, risk factors, and clinical outcomes of acute kidney injury associated with acute pyelonephritis in patients attending a tertiary care referral center.
Authors: Jeon DH, Jang HN, Cho HS, Lee TW, Bae E, Chang SH, Park DJ Abstract Acute kidney injury (AKI) associated with acute pyelonephritis (APN) rarely has been reported. The aim of this study was to evaluate the incidence and risk factors of AKI associated with APN. We retrospectively reviewed the medical records of 403 patients over 18-year old age hospitalized for APN management from October 2009 to September 2014 in tertiary care referral center. Demographic data, clinical symptoms and signs, and laboratory findings were gathered from the medical records and analyzed. The mean age of patients was 57 years...
Source: Renal Failure - April 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research