Challenges in treatment and diagnosis of forgotten/encrusted double-J ureteral stents: the largest single-center experience.
CONCLUSIONS: Forgotten/encrusted DJS may lead to complications in a range of urinary system infections, up to a loss of renal function. They can be safely and successfully removed, and the renal function can be preserved by endourologic techniques, starting with the least invasive procedures in centers highly experienced. PMID: 27089423 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 20, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A diagnostic dilemma: lupus nephritis or renal polyarteritis nodosa?
Authors: Bhushan S, Abreo K, Rodziewicz N, Gu X, Singh N Abstract Lupus nephritis and renal polyarteritis nodosa (PAN) are two distinct disorders that rarely overlap. Herein, we describe a patient who was initially diagnosed with lupus nephritis based on her clinical presentation, proteinuria, hematuria, positive anti-nuclear antibody, and a kidney biopsy. A month later, the patient presented with left flank pain and weakness. A CT scan of the abdomen and pelvis showed a perinephric hematoma and the renal arteriogram revealed numerous microaneurysms within the kidney consistent with renal PAN. This case elucidates ...
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of calcium channels blockers and inhibitors of the renin-angiotensin system on renal outcomes and mortality in patients suffering from chronic kidney disease: systematic review and meta-analysis.
CONCLUSIONS: CCBs did not increase all-cause mortality incidence in patients with CKD though they displayed weaker renoprotective, compared to ACEIs or ARBs therapy. Our results suggest the combination of a CCB and an ACEI or ARB should be a preferable antihypertensive therapy in patients with CKD, considering their higher effect in decreasing blood pressure and fewer adverse metabolic problems caused. PMID: 27055479 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Consumption of nitrate containing vegetables and the risk of chronic kidney disease: Tehran Lipid and Glucose Study.
In this study, we investigated the association of nitrate-containing vegetables (NCVs) and the risk of chronic kidney disease (CKD). METHODS: We evaluated 1546 eligible adult participants of the Tehran Lipid and Glucose Study (TLGS), at baseline (2006-2008) and again after 3 years (2009-2011). Dietary intake was collected using the validated semi-quantitative food frequency questionnaire. Nitrate-containing vegetables and its categories including high-, medium-, and low-nitrate vegetables were defined. Estimated glomerular filtration rate (eGFR) and CKD were defined. Association between NCVs and CKD in the cross-sectio...
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Urinary markers of acute kidney injury in newborns with perinatal asphyxia.
Authors: Oncel MY, Canpolat FE, Arayici S, Alyamac Dizdar E, Uras N, Oguz SS Abstract BACKGROUND: Acute kidney injury (AKI) affects up to 60% of severely asphyxiated neonates. The diagnosis of AKI can be and is further challenged by a lack of good biomarkers. We studied the role of novel markers for AKI, neutrophil gelatinase-associated lipocalin (NGAL), interleukin-8 (IL-18), Netrin-1 (NTN-1), and sodium hydrogen exchanger isoform 3 (NHE3) on development and early diagnosis of AKI in newborns with perinatal asphyxia (PA). METHODS: Forty-one newborns with a diagnosis of PA (15 with AKI and 26 without AKI) and 2...
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The possible role of interleukin-33 as a new player in the pathogenesis of contrast-induced nephropathy in diabetic rats.
CONCLUSION: The release of IL-33 from necrotic cells might induce autophagy, which can further balance the effects of increased apoptosis secondary to CN in DKD. PMID: 27055881 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The association of the Klotho polymorphism rs9536314 with parameters of calcium-phosphate metabolism in patients on long-term hemodialysis.
CONCLUSIONS: The results obtained may indicate that there is no association between the KL polymorphism and FGF23 concentration in patients undergoing long-term. PMID: 27055909 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction.
Authors: Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS, Bodhankar SL Abstract BACKGROUND: Gentamicin (GM) is the commonly used antibiotics against Gram-negative infection, but the nephrotoxic potential of drug limit its clinical interest. The aim of this study was to investigate the protective effect of berberine (BER) against GM-induced nephrotoxicity and possible underlying mechanisms. MATERIAL AND METHODS: The rats were divided into various group, namely normal, GM-control, GM + BER (10, 20, and 40 mg/kg). Nephrotoxicity was induced by intraperitoneal administration of GM ...
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Modification of the Schwartz equations for children increases their accuracy at eGFR > 60 mL/min/1.73 m(2).
CONCLUSIONS: Modifications of Schwartz equations at GFR > 60 ml/min/1.73m(2) significantly improves the accuracy of calculating eGFR. The 3-markers equation is more accurate and should be employed frequently. PMID: 27056090 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

MicroRNA-206 and its down-regulation of Wilms'Tumor-1 dictate podocyte health in adriamycin-induced nephropathy.
CONCLUSIONS: Over expression of miR-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for FSGS and miR-206 may be a potential therapeutic target. PMID: 27056206 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Abnormal circadian blood pressure regulation in children with nocturnal enuresis.
Authors: Yüce Ö, Bayrakçi US, Gülleroğlu K, Baskın E Abstract INTRODUCTION: To investigate autonomic nervous system function in enuretic children by performing ambulatory blood pressure monitor (ABPM) for 24 h. METHODS: Twenty-eight children ranging in age from 6 to 15 years with primary nocturnal enuresis and 27 age-matched healthy controls were enrolled and they get 24 h ABPM. Hypertension was defined as standard deviation score (SDS) > 1.64 (i.e.,>95th percentile) adjusted for gender and height. Urinalysis, urine electrolyte levels, urinary culture, a...
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of Ligustrazine on rat peritoneal mesothelial cells treated with lipopolysaccharide.
Authors: Zhang H, Li D, Li Z, Song Y Abstract The apoptosis of peritoneal mesothelial cells (PMCs) and peritoneal fibrosis may induce failure of peritoneal membrane function. The study explored the changes of apoptosis and fibrosis in PMCs under lipopolysaccharides (LPS) culture and investigated whether Ligustrazine can affect LPS-induced apoptosis and fibrosis. We found that exposure of rat PMCs to 5 mg·L(-1) LPS for 24 h resulted in a significant induction of apoptosis and increased levels in Reactive oxygen species, and caspase-3 activity. Fibronectin, Collagen I, p-p38, and matrix metallopr...
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparing long-term outcomes between early and delayed initiation of peritoneal dialysis following catheter implantation.
CONCLUSION: Compared to the patients who started peritoneal dialysis 14 days or more after catheter implantation, the patients who started earlier did not have an increased risk of peritonitis, peritoneal dialysis technique failure and mortality. PMID: 27056580 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 9, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The efficacy of theophylline in preventing cisplatin-related nephrotoxicity in patients with cancer.
Authors: Karademir LD, Dogruel F, Kocyigit I, Yazici C, Unal A, Sipahioglu MH, Oymak O, Tokgoz B Abstract OBJECTIVE: Cisplatin is a potent antineoplastic agent used and its major limiting side effect is nephrotoxicity. The aims of the study are early detection of acute kidney injury (AKI) with biomarkers and investigation of the potential nephron-protective effects of theophylline. METHODS: Glomerular filtration rates (GFR), neutrophil gelatinase-associated lipocalin (NGAL), cystatin C were measured at 5th day of treatment in all of the patients. In addition, these parameters were measured repeatedly after the ...
Source: Renal Failure - April 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?
Authors: Sarkar T, Singh NP, Kar P, Husain SA, Kapoor S, Pollipalli SK, Kumar A, Garg N Abstract BACKGROUND: Hypertension is one of the important contributing factors linked with both causation and development of kidney disease. It is a multifactorial, polygenic, and complex disorder due to interaction of several risk genes with environmental factors. The present study was aimed to explore genetic polymorphism in ACE-1 gene as a risk factor for CKD among hypertensive patients. METHODS: Three hundred patients were enrolled in the study. Ninety were hypertensive patients with CKD taken as cases, whereas 210 hyper...
Source: Renal Failure - April 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
CONCLUSIONS: This markedly decreased ARE activity in CKD patients, which could not be explained by the anemia alone, may have a role in the pathogenesis of increased atherosclerosis in such patients. Still further studies are needed to certain this. PMID: 27050633 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - April 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Clinicopathological features and risk factors analysis of IgA nephropathy associated with acute kidney injury.
Authors: Zhang L, Li J, Yang S, Huang N, Zhou Q, Yang Q, Yu X Abstract OBJECTIVE: The aim of this work is to investigate the distinctive clinicopathological characteristics of AKI in Chinese IgAN population and possible risk factors for AKI. METHODS: We performed a retrospective analysis of 1512 patients with biopsy-proven primary IgAN in the period 2006 through 2011 in The First Affiliated Hospital of Sun Yat-sen University. AKI was defined as 2012 KDIGO (Kidney Diseases: Improving Global Outcomes) criteria, and the patients were divided into AKI group (n = 145) and non-AKI group (n =&thin...
Source: Renal Failure - April 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-β1-Smad3 pathway.
This study investigated whether oxymatrine (OMT) treatment can ameliorate renal interstitial fibrosis in unilateral ureteral obstruction (UUO) mice model. Moreover, the potential mechanisms of such treatment were analyzed. Twenty-four C57/BL6 mice were randomly divided into three groups, namely sham group, vehicle plus unilateral ureteral obstruction (UUO)-treated group, and 100 mg/kg/d OMT plus UUO-treated group. All mice were euthanized seven days after surgery, and their kidneys were harvested. Renal injury, fibrosis, expression of proinflammatory cytokines, and the transforming growth factor-β1/Smads (TGF-&...
Source: Renal Failure - April 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1.
Authors: Adil M, Kandhare AD, Ghosh P, Venkata S, Raygude KS, Bodhankar SL Abstract CONTEXT: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid possesses multiple pharmacological properties such as antioxidant, anti-inflammatory, analgesic and anti-hyperlipidemic activity. OBJECTIVE: To evaluate the effect of naringin against the APAP-induced hepatic and renal toxicity. MATERIALS AND METHODS: Male Wistar albino rats (180-220 g) were divided into various groups, and toxicity was induced by APAP ...
Source: Renal Failure - April 8, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Indoxyl sulfate promotes vascular smooth muscle cell calcification via the JNK/Pit-1 pathway.
Authors: Wu Y, Han X, Wang L, Diao Z, Liu W Abstract We determined the effect of indoxyl sulfate (IS) on Pit-1 expression and the role of Pit-1 in IS-induced osteoblastic differentiation and calcification of vascular smooth muscle cells (VSMCs). To assess osteoblastic differentiation and Pit-1 expression, VSMCs were incubated with various concentrations of IS for different durations. Phosphonoformic acid (PFA), a competitive inhibitor of Pit-1, was used to verify the role of Pit-1. Western blot analysis and quantitative real-time polymerase chain reaction (PCR) were performed to assess Pit-1 protein and mRNA levels...
Source: Renal Failure - March 25, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Sclerostin levels in uremic patients: a link between bone and vascular disease.
Authors: Bruzzese A, Lacquaniti A, Cernaro V, Ricciardi CA, Loddo S, Romeo A, Montalto G, Costantino G, Torre F, Pettinato G, Salamone I, Aloisi C, Santoro D, Buemi M Abstract Sclerostin is a marker of low-turnover bone disease in end stage renal disease patients. The aim of this study was to evaluate serum sclerostin in uremic patients, analyzing its behavior during a single hemodialysis session. Twenty-one adult patients on intermittent hemodialysis treatment were enrolled. Acetate Free Bio-filtration (AFB) was the technique employed. Uremic patients were characterized by higher levels of serum sclerostin when co...
Source: Renal Failure - March 25, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Endoplasmic reticulum stress and its effects on renal tubular cells apoptosis in ischemic acute kidney injury.
Authors: Xu Y, Guo M, Jiang W, Dong H, Han Y, An XF, Zhang J Abstract Ischemia is the most frequent cause of acute kidney injury (AKI), which is characterized by apoptosis of renal tubular cell. A common result of ischemia in AKI is dysfunction of endoplasmic reticulum (ER), which causes the protein-folding capacity to lag behind the protein-folding load. The abundance of misfolded proteins stressed the ER and results in induction of the unfolded protein response (UPR). While the UPR is an adaptive response, over time it can result in apoptosis when cells are unable to recover quickly. Recent research suggests that...
Source: Renal Failure - March 25, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model.
Authors: Karahan MA, Yalcin S, Aydogan H, Büyükfirat E, Kücük A, Kocarslan S, Yüce HH, Taskın A, Aksoy N Abstract Curcumin and dexmedetomidine have been shown to have protective effects in ischemia-reperfusion injury on various organs. However, their protective effects on kidney tissue against ischemia-reperfusion injury remain unclear. We aimed to determine whether curcumin or dexmedetomidine prevents renal tissue from injury that was induced by hind limb ischemia-reperfusion in rats. Fifty rats were divided into five groups: sham, control, curcumin (CUR) group (200 mg/kg curcumin,...
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study.
Conclusion Treatment using MZR in combination with methylprednisolone and entecavir in HBV-positive nephrotic syndrome patients displays significant efficacy with a low incidence of adverse reactions. PMID: 26983690 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Correlation of bioelectrical impedance analysis phase angle with changes in oxidative stress on end-stage renal disease patients, before, during, and after dialysis.
In this study, the correlation of the PhA with parameters of oxidative stress is attempted for the first time. We evaluated parameters of oxidative status as total antioxidant capacity (TAC) in erythrocytes (RBCs) and plasma of patients with ESRD undergoing hemodialysis with low flux synthetic polysulfone membranes. Measurements were recorded from 30 patients (16 men and 14 women) aged 64 ± 14 years before, during, and after dialysis, and in 15 healthy volunteers aged 56 ± 12 years The PhA was obtained by BIA. The plasma TAC increased significantly (41%, p 
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Paricalcitol may improve oxidative DNA damage on experimental amikacin-induced nephrotoxicity model.
This study aimed to investigate the possible protective effect of paricalcitol on experimental amikacin-induced nephrotoxicity model in rats. Wistar albino rats (n = 32) were allocated into four equal groups of eight each, the control (Group C), paricalcitol (Group P), amikacin-induced nephrotoxicity (Group A), and paricalcitol-treated amikacin-induced nephrotoxicity (Group A + P) groups. Paricalcitol was given intra-peritoneally at a dose of 0.4 μg/kg/d for 5 consecutive days prior to induction of amikacin-induced nephrotoxicity. Intra-peritoneal amikacin (1.2 g/kg) was used to...
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Assessed value of high-sensitivity cardiac troponin T for cardiovascular disease among CKD patients.
Authors: Sun L, Tan X, Cao X, Zou J Abstract Objective To analyze the relationship between serum high-sensitivity cardiac troponin T (hs-cTnT) and cardiovascular disease (CVD) among non-dialysis chronic kidney disease (CKD) patients, and to further explore its value of evaluating and predicting CVD in this population. Methods Five hundred and fifty-seven non-dialysis CKD patients were involved in this cross-sectional study. The relationship between serum hs-cTnT and CVD was analyzed using comparison between groups and regression analysis, and its value on assessing cardiac structure and function was evaluated by RO...
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

CTGF mediates high-glucose induced epithelial-mesenchymal transition through activation of β-catenin in podocytes.
Conclusion CTGF and β-catenin are involved in the EMT of podocytes in diabetes. CTGF mediates high-glucose induced EMT through activation of β-catenin in podocytes. CTGF inhibition may protect podocytes from EMT in diabetes. PMID: 26984259 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Biochemical and histopathological responses of the Swiss albino mice treated with uranyl nitrate and its recovery.
Authors: Sangeetha Vijayan P, Rekha PD, Dinesh U, Arun AB Abstract Uranium is a radioactive heavy metal ubiquitous in the natural environment. In its chemical form, it is known to induce nephrotoxicity both in human and in animals. Its toxicity is dose and time dependent, also varies with form of uranium. In the present study, we assessed the nephrotoxicity induced by a single dose of uranyl nitrate (UN) in mice at different time intervals and recovery from its toxicity. Two doses of 2 and 4 mg/kg body weight of uranyl nitrate was injected intraperitoneally and animals were sacrificed after 1, 3, 5, 14, and ...
Source: Renal Failure - March 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Septic acute kidney injury in critically ill patients - a single-center study on its incidence, clinical characteristics, and outcome predictors.
The objective of this study is to examine the incidence, clinical characteristics, and outcome (90-day mortality) of critically ill Chinese patients with septic AKI. Methods Patients admitted to the ICU of a regional hospital from 1 January 2011 to 31 December 2013 were included, excluding those on chronic renal replacement therapy. AKI was defined using KDIGO criteria. Patients were followed till 90 days from ICU admission or death, whichever occurred earlier. Demographics, diagnosis, clinical characteristics, and outcome were analyzed. Results In total, 3687 patients were included and 54.7% patients developed AKI. Sepsis...
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells.
Authors: Kurt AH, Bozkus F, Uremis N, Uremis MM Abstract Nephrotoxicity is an important problem during methotrexate (MTX) treatment, which has been widely used for the treatment of several cancer types. Females are less susceptible to kidney diseases; however, the reason for this condition has not to be fully clarified. But sex hormones such as estrogen may have a protective effect on the kidney. We aimed to evaluate the possible protective role of estrogen on the MTX-induced renal epithelial cell death. Primary renal proximal tubular epithelial cells (RPTEC) were incubated with MTX (1, 10 and 100 μM), ei...
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of propolis on methotrexate-induced kidney injury in the rat.
Conclusions It was found that methotrexate gives rise to serious damage in the kidney and propolis is a potent antioxidant agent in preventing kidney injury. PMID: 26981953 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion.
Conclusions These results suggest that RPEC reduces the dysfunction and injury associated with I/R of the kidney. This technique reduced the pro-inflammatory cytokine in the kidney. RPEC could be a promising strategy against I/R-induced acute kidney injury partly by down-regulation of inflammatory mediators. PMID: 26982574 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Amikacin induced renal damage and the role of the antioxidants on neonatal rats.
In this study, on neonatal rats, we aimed to investigate the effects of erythropoietin and vitamin E on AK induced nephrotoxicity. A total of 35 newborn Wistar Albino rats were divided into four groups: (1) injected with saline (serum physiological was administered to placebo controls), (2) injected with AK (1200 mg/kg), (3) injected with AK + vitamin E (150 mg/kg), (4) injected with AK + erythropoietin (EPO) (300 IU/kg/day). In renal tissue, AK levels were significantly high in all groups except the control. Tissue malondialdehyde (MDA) and nitric oxide (NO) levels were sta...
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of serum cysteine-rich protein 61 and cystatin C levels for assessment of acute kidney injury after cardiac surgery.
Authors: Mosa OF, Skitek M, Kalisnik JM, Jerin A Abstract Objective The occurrence of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) can lead to morbidity and mortality. We hypothesized that cysteine-rich protein 61 (CYR61) and cystatin C (CysC) may be potential novel biomarkers of AKI after cardiopulmonary bypass. Methods Patients were classified into AKI and non-AKI group depending on serum creatinine. Levels of creatinine, CysC, and CYR61 were measured at five time-points before and within 48 h after the surgery. Results Fifty patients were included in the study. Serum creatinine pre-operati...
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of interleukin 18-607A/C and -137C/G polymorphisms with oxidative stress in renal transplant recipients.
Conclusion Our results indicate that the IL-18-137 GG and -607 CC genotypes contribute to higher IL-18 levels; however, the influence of these polymorphisms on oxidative stress has not been observed. PMID: 26983036 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Higher risk of urothelial carcinoma in the upper urinary tract than in the urinary bladder in hemodialysis patients.
Conclusion Patients with ESRD on HD are at a high risk of developing UC, especially UTUC in Taiwan. They will be paid more frequent to check urine analysis, urine cytology, and upper urinary tract survey. PMID: 26956094 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - March 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Cyclocarya paliurus extract alleviates diabetic nephropathy by inhibiting oxidative stress and aldose reductase.
This study investigated the protective effect of the aqueous extract from leaves of Cyclocarya paliurus (Batal.) Iljinsk (ACP) on DN by inhibiting oxidative stress and aldose reductase (AR) activity. ACP was obtained by hot water extraction. The in vitro antioxidant capability and AR inhibition of ACP were investigated by employing various established systems. DN rats were used to assess the reno-protective effect of ACP. Results showed that the polysaccharide and total polyphenol contents of ACP were (479.3 ± 19.8) mg/g and (38.3 ± 2.3) mg/g, respectively. ACP exhibited strong ant...
Source: Renal Failure - March 10, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Laparoscopic versus traditional peritoneal dialysis catheter insertion: a meta analysis.
The objective of this study is to compare the catheter-related complications as well as catheter survival between laparoscopic and traditional surgery in peritoneal dialysis catheter insertion. RESULTS: Five randomized controlled trials and 11 cohort studies were identified. Meta-analysis showed laparoscopic catheter is superior to traditional surgery in terms of controlling catheter migration (OR 0.17, 95% CI 0.08-0.33; p 
Source: Renal Failure - March 6, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Brachiobasilic fistulae: an upper limb autologous option for everyone?
Authors: Hameed H, Aitken E, Al-Moasseb Z, Kingsmore D Abstract Purpose Autologous arteriovenous fistulae (AVF) are the vascular access option of choice. However, Brachiobasilic fistula (BBF) are complex procedures with variable outcomes reported in the literature. Our aim was to evaluate outcomes and morbidity associated with BBF in our population. Methods Retrospective analysis of prospectively collected data was undertaken for all 51 BBF created in our institution between January 2010 and March 2013. These were compared to an age and sex-matched group of brachiocephalic fistula (BCF) created over a similar time ...
Source: Renal Failure - March 1, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Regulation of eIF2α expression and renal interstitial fibrosis by resveratrol in rat renal tissue after unilateral ureteral obstruction.
This study was performed to assess the effect of resveratrol on the expression of eukaryotic initiation factor 2α (eIF2α) and activating transcription factor 4 (ATF4) in renal tissues of rats with unilateral ureteral obstruction (UUO). Methods Using UUO animal model, after 14 days of surgery, pathological changes were detected by HE staining, renal tubular damage index, renal interstitial collagen deposition area were evaluated by Masson staining, in situ cell apoptosis in renal tissue was analyzed by TUNEL assay, and protein expression of eIF2α and ATF4 in renal tissue was analyzed using western blot det...
Source: Renal Failure - March 1, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute renal failure in Ebola viral disease: does new immunomodulation concept by statin acceptable for management?
Authors: Wiwanitkit V PMID: 26915267 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 29, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats.
Authors: Wang M, Weng X, Guo J, Chen Z, Jiang G, Liu X Abstract Purpose The purpose of this study is to assess the potential effects of metformin on the development of EMT and tubulointerstitial fibrosis 12 weeks after acute renal ischemia-reperfusion. Methods Male Sprague-Dawley rats were randomly assigned to four groups: Sham, IRI, transient administration of metformin (TAM), and continuous administration of metformin (CAM). Metformin was administered i.p. at a dose of 125 μg kg (- 1) d( - 1) 3 d prior to suffering from IRI (TAM), or from 3 d before suffering from IRI to 12 w...
Source: Renal Failure - February 29, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective effect of syringic acid on kidney ischemia-reperfusion injury.
The objective of the present study was to determine whether preischemic administration of syringic acid (SA) would attenuate renal ischemia-reperfusion injury (IRI). Rats were divided into three groups: Sham group; IR group; and IR + SA group. The effects of SA were examined using biochemical parameters including serum ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tissue superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA). The apoptosis status and histopathological changes were evaluated...
Source: Renal Failure - February 29, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The efficacy and safety of dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus patients with severe renal impairment: a meta-analysis.
Authors: Chen M, Liu Y, Jin J, He Q Abstract Aims/introduction Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agents, and have been increasingly and widely used in the treatment of diabetes mellitus (DM). However, information of DPP-4 inhibitors in type 2 DM patients with severe renal impairment (RI) is limited. Our study aimed to assess the efficacy and safety of DPP-4 inhibitors as compared to placebos or other hypoglycemic drugs in type 2 DM patients with severe RI. Materials and methods A meta-analysis was conducted to examine the literature comparing the effects of...
Source: Renal Failure - February 29, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Lipoic acid does not improve renal function markers in 5/6 nephrectomy model: possible role of Nrf2 inactivation.
Authors: Lo SM, Dal Lin FT, Soares MF, Hauser AB, Pecoits-Filho R, Nakao LS Abstract Chronic kidney disease (CKD) progression and complications are associated with increased oxidative stress, as well as with Nrf2 inactivation. Lipoic acid (LA) has been considered an inducer of Nrf2 antioxidant response. We tested whether oral administration of LA provides beneficial effects in experimental CKD in rats. Wistar rats underwent 5/6 nephrectomy (CKD group) or sham laparotomy. Seven days later, CKD group was divided into three subgroups that received: (i) LA continuously in the drinking water (100 mg/kg/day), (ii)...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Evaluation of the ability of bone marrow derived cells to engraft the kidney and promote renal tubular regeneration in mice following exposure to cisplatin.
Authors: Bataille A, Galichon P, Wetzstein M, Legouis D, Vandermeersch S, Rondeau E, Hertig A Abstract It has been suggested that bone marrow derived stem cells have the ability to engraft the kidney and improve the outcome of severe acute kidney injury (AKI) in mice exposed to high doses of cisplatin, providing hope for cancer patients in whom irreversible renal damage occasionally occurs following the use of this highly effective anti-tumor drug. We tested the therapeutic potential of bone marrow derived cells injected during the acute phase (day 3 after cisplatin administration) of experimentally-induced AKI in ...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Safety and cardiovascular effects of mineralocorticoid receptor antagonists for patients receiving hemodialysis: a systematic review and meta-analysis.
Conclusion It is safe to use low dose mineralocorticoid receptor antagonists on patients receiving hemodialysis, at the end of each session of hemodialysis, and close monitoring of serum potassium levels and possible side effects is necessary. The cardiovascular actions still need to be explored and large scale RCTs are in progress. PMID: 26905224 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of long-term pre- and post-natal exposure to 2.45 GHz wireless devices on developing male rat kidney.
Effects of long-term pre- and post-natal exposure to 2.45 GHz wireless devices on developing male rat kidney. Ren Fail. 2016 Feb 24;:1-10 Authors: Kuybulu AE, Öktem F, Çiriş İM, Sutcu R, Örmeci AR, Çömlekçi S, Uz E Abstract Purpose The aim of the present study was to investigate oxidative stress and apoptosis in kidney tissues of male Wistar rats that pre- and postnatally exposed to wireless electromagnetic field (EMF) with an internet frequency of 2.45 GHz for a long time. Methods The study was conducted in three groups of rats which were pre-natal, ...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effect of arteriovenous fistula and usage of arm with fistula on bone mineral density in hemodialysis patients.
Authors: Turk AC, Sahin F, Ozkurt S, Tomak L, Guray G Abstract We aimed to determine the incidence of osteoporosis in hemodialysis patients, to evaluate the differences due to arteriovenous fistula on bone mineral density (BMD) and to investigate whether usage of arm with fistula has an effect on BMD. In this cross-sectional study, 96 patients with chronic renal disease undergone to dialysis were included. Place of fistula (radial and brachial) and dominant hand were recorded. All patients were asked to complete Likert's scale in order to determine the frequency of their usage of arm with fistula. Patients were ass...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research