Effect of arteriovenous fistula and usage of arm with fistula on bone mineral density in hemodialysis patients.
Authors: Turk AC, Sahin F, Ozkurt S, Tomak L, Guray G Abstract We aimed to determine the incidence of osteoporosis in hemodialysis patients, to evaluate the differences due to arteriovenous fistula on bone mineral density (BMD) and to investigate whether usage of arm with fistula has an effect on BMD. In this cross-sectional study, 96 patients with chronic renal disease undergone to dialysis were included. Place of fistula (radial and brachial) and dominant hand were recorded. All patients were asked to complete Likert's scale in order to determine the frequency of their usage of arm with fistula. Patients were ass...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ameliorative effects of pentoxifylline on NOS induced by diabetes in rat kidney.
Conclusion In conclusion, PTX has a healing effect on this damage by affecting NOS expression. PMID: 26905686 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats.
In conclusion, TAC restores podocyte injury and stabilizes the expression of Cabin1. Cabin1 may become a new target to demonstrate the mechanism of TAC in podocyte injury. PMID: 26905810 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ultrasonographic evaluation of the femoral cartilage thickness in patients with chronic renal failure.
Conclusion In the light of our findings, we imply that patients with CRF have thinner femoral cartilage than healthy controls. This result may support the view that patients with CRF are at increased risk for developing early knee osteoarthritis. Last but not least, clinicians should be aware of the importance of rehabilitation strategies aimed at decreasing onset and progression of knee osteoarthritis in patients with CRF. PMID: 26905953 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Is there a role for urinary podocyte excretion assessment in lupus nephritis?
Conclusions Podocyturia assessment, which was performed by immunofluorescence in this study, can be used as an indicator of disease activity with the advantage of being a urinary biomarker. The levels proved to be higher in patients with lupus nephritis than in the controls and were particularly higher in class IV. PMID: 26906105 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats.
Authors: Chen Z, Liu X, Yu G, Chen H, Wang L, Wang Z, Qiu T, Weng X Abstract Tubulointerstitium inflammation is a common pathway aggravating chronic kidney disease (CKD) progression and the mechanism is partly associated with excessive activation of toll-like receptor 4 (TLR4) in tubulointerstitium. Ozone therapy is demonstrated to alleviate inflammation in some experiments. The aim of this study is to examine whether ozone therapy could ameliorate chronic tubulointerstitium inflammation by suppressing TLR4 in adenine-induced CKD rats. Sprague-Dawley rats were fed with 0.75% adenine-containing diet to induce CKD an...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Serum tumor markers in chronic kidney disease: as clinical tool in diagnosis, treatment and prognosis of cancers.
Authors: Amiri FS Abstract Cancer is singled out as the biggest cause of death in the world, predicted to reach 13.1 million cancer-related deaths by the year 2030. Although there are no specific tumor markers used in cancer screening, some markers can be used to assist in making a diagnosis and determining a prognosis. They can be used to follow in cases where the diagnosis is cancer through monitoring of the disease recurrence and/or evaluating the response to therapy. These markers are not specific as the number increases in multiple cases of cancer. Some markers are positive in a single type of cancer; others a...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis.
Authors: Goknar N, Öktem F, Torun E, Gok O, Demir AD, Kucukkoc M, Kilic U Abstract Polymorphisms in the vitamin D receptor (VDR) gene have recently been reported to be associated with urinary calculi in pediatric and adult cases, but no studies have looked at the youngest period of life. The purpose of this study was to investigate the role of VDR gene polymorphisms in infantile urolithiasis in a Turkish population. We compared a study group of 104 infants (55 girls and 49 boys, mean age 6.94 ± 3.81 months) with a control group of 96 infants (51 girls and 45 boys, mean age 7.51 &plu...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of Gingko biloba extract (EGb 761) on vascular smooth muscle cell calcification induced by β-glycerophosphate.
Effects of Gingko biloba extract (EGb 761) on vascular smooth muscle cell calcification induced by β-glycerophosphate. Ren Fail. 2016 Feb 24;:1-6 Authors: Li EG, Tian J, Xu ZH Abstract Objective To investigate the effects of Gingko biloba extract (EGb 761) on calcification induced by β-glycerophosphate in rat aortic vascular smooth muscle cells. Methods Rat aortic vascular smooth muscle cells were cultured with various concentrations of EGb 761 and β-glycerophosphate for 7 days. Calcium content in the cells, alkaline phosphatase activity, cell protein content, NF-κB activation, and...
Source: Renal Failure - February 27, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Retrograde Intrarenal Surgery is equally efficient and safe in patients with different American Society of Anesthesia physical status.
Conclusions Retrograde Intrarenal Surgery is an effective and safe surgery with high stone-free rates and low morbidity in patients with different ASA physical status. PMID: 26895083 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats.
Authors: Yang P, Li Y, Xu G Abstract Background The roles of antioxidant therapy on non-thyroidal illness syndrome (NTIS) in uremic rats is still unclear. Materials and methods Twenty-four Sprague-Dawley (SD) rats were randomly divided into blank, 5/6 nephrectomy (Nx), pyrrolidine dithiocarbamate (PDTC, 10 mg/100 g), sodium bicarbonate (SB, 0.1 g/100 g), N-acetylcysteine (NAC, 80 mg/100 g) and thyroid hormones (TH, levothyroxine 2 μg/100 g) groups. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), advanced oxidation protein products (AO...
Source: Renal Failure - February 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

MicroRNA-939 down-regulates CD2-associated protein by targeting promoter in HEK-293T cells.
In conclusion, we have identified that miR-939 targets CD2AP promoter sequences and suppresses its gene expression. These findings suggest that miRNAs may mediate podocyte injury via reducing the expression of the SD proteins, such as CD2AP. PMID: 26895305 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 21, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

A novel rodent model of severe renal ischemia reperfusion injury.
Authors: Whalen H, Shiels P, Littlejohn M, Clancy M Abstract Renal ischemia reperfusion injury (IRI) is a major problem, currently without treatments in clinical use. This reflects the failure of animal models to mimic the severity of IRI observed in clinical practice. Most described models lack both the ability to inflict a permanent reduction in renal function and the sensitivity to demonstrate the protective efficacy of different therapies in vivo. To test novel cell-based therapies, we have developed a model of renal IRI in Fisher 344 rats. Animals were subjected to 120 min of unilateral warm ischemia, d...
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Factors related to fatigue in Chinese patients with end-stage renal disease receiving maintenance hemodialysis: a multi-center cross-sectional study.
This study aimed to assess fatigue in hemodialysis patients and to investigate risk factors of fatigue in Chinese patients receiving maintenance hemodialysis (MHD) in China. Methods Eligible patients completed questionnaires including demographic information, a Chinese version of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), the Family APGAR Index (APGAR), the medical outcomes study health status-Social Functioning subscale (SF-36,SocF), and the Pittsburgh sleep quality index (PSQI). Laboratory parameters were abstracted by medical records review. The multiple linear regression model was use...
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Prevalence and risk factors for pulmonary arterial hypertension in end-stage renal disease patients undergoing continuous ambulatory peritoneal dialysis.
Authors: Zhang L, Zhao S, Ma J, Gong J, Qiu G, Ren Y, Zen Y, Shi Y Abstract BACKGROUND: Pulmonary arterial hypertension (PAH) is a major complication in renal failure patients, but very little information is available on the cardiovascular parameters in these patients. The prevalence and risk factors for PAH were systematically evaluated in patients with end-stage renal diseases (ESRD) undergoing continuous ambulatory peritoneal dialysis (CAPD). METHODS: Between January 2010 and January 2014, 177 ESRD patients (85 males and 92 females) undergoing CAPD therapy were recruited. General data, biochemical parameters...
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Inhalation of mercury vapor can cause the toxic effects on rat kidney.
In this study, the effects of mercury intake on kidney in rats were searched. For the this purpose; we used 24 adult female Wistar albino rats (200 g in weight) obtained from Experimental Research and Application Center of Atatürk University with ethical approval. Besides, they were placed into a specially designed glass cage. Along this experiment for 45 days, subjects were exposed to (1 mg/m(3)/day) mercury vapor. However, no application was used for the control subjects. At the end of the experiment, kidney samples were obtained from all subjects and processed for routine light microscopic level and s...
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Pretransplant uric acid levels may be predictive for prognosis of renal transplant donors.
Conclusion Pretransplant serum UA levels can give important clues regarding the renal functions of the donors during the postoperative period. PMID: 26888379 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Autosomal dominant polycystic kidney disease and coronary artery dissection or aneurysm: a systematic review.
Conclusion and relevance Clinical disparities may suggest a different mechanism of aneurysm formation compared to the population without ADPKD. Nevertheless, lack of access to data of one patient and text of one article limited our conclusions. Coronary aneurysms and dissections represent a source of coronary syndromes and death in ADPKD. Mutation of ADPKD-related genes may predispose to coronary abnormalities, especially aneurysms. Further analysis regarding this association is necessary. PMID: 26888492 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of lipid profile with serum PON1 concentration in patients with chronic kidney disease.
This study intends to compare the association between lipid profile and serum PON1 levels in renal failure (RF) and hemodialysis (HD) patients. Serum lipids, HDL-subclasses and PON1 concentration were evaluated in 90 patients with CKD, divided into groups: RF (n = 46) and HD (n = 44), and in 30 normal individuals (control group). The results showed that PON1 was significantly lower in HD patients than in RF and controls (p 
Source: Renal Failure - February 19, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Acute kidney injury in pregnancy--a single center experience.
CONCLUSION: AKI in pregnancy was common in postpartum period and sepsis being the commonest cause. PMID: 26338215 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Do the variations in renal pelvic angles play a role in the formation of renal stone? A computed tomography study.
In this study, we aimed to investigate the effect of variations in renal pelvic angle on urinary calculi development. MATERIALS AND METHODS: A total of 2456 unenhanced abdominal CT scans were retrospectively evaluated and 262 kidneys of 131 patients were compared. Patients included in this study were identified and qualified as follows: Having unilateral calculi, having no calculi or a history of calculi in contra-lateral side and having totally normal renal morphology. RESULTS: The mean angle of kidneys with calculi was 55 ± 9°, while the average angle measurement was 61 ±&th...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The relation between neutrophil-lymphocyte ratio and acute kidney injury.
Authors: Balta S, Uslu AU, Unlu M, Demirkol S, Ozturk C PMID: 26338440 [PubMed - indexed for MEDLINE] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

L-Carnitine inhibits eryptosis induced by uremic serum and the related mechanisms.
Authors: Sun Y, Liu G, Li X, Shi Y, Guan G Abstract OBJECTIVE: To investigate whether L-carnitine (LC) inhibits eryptosis induced by uremic serum and the related mechanism. METHODS: One percent erythrocyte suspension was cultured by three kinds of mediums in vitro, which was included in the control group (Group C, phosphate buffered saline [PBS]), the uremic serum group (Group U, 30% uremic serum + 70% PBS) and the LC group (Group L, 30% uremic serum + 70% PBS + 200 umol/L LC), respectively. Erythrocytes were collected at 24 and 48 h, respectively. Phosphatidylserine (PS) was estimated from Annexin-V-binding an...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association and interaction analysis of excess weight and chronic kidney disease for cardiovascular autonomic neuropathy in the general Chinese population.
CONCLUSION: Our findings suggest that BMI is independently associated with CAN and offer evidence to support the hypothesis that excess weight and CKD have significant positive interactions on CAN. PMID: 26360668 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Potential biomarkers associated with diabetic glomerulopathy through proteomics.
Authors: Hsu YC, Lei CC, Ho C, Shih YH, Lin CL Abstract Diabetic nephropathy (DN) is characterized by the development of progressive glomerulosclerotic lesions gradually leading to an increasing loss of functioning kidney parenchyma. Relatively little proteomic research of isolated glomeruli of experimental animal models has been done so far. Isolated glomerular proteomics is an innovative tool that potentially detects simultaneous expressions of glomeruli in diabetic pathological contexts. We compared the isolated glomerular profiles of rats with and without diabetes. The proteins in the aliquots of glomeruli were...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Early stage of vascular disease and diabetic kidney disease: an under-recognized entity.
Authors: Futrakul N, Chanakul A, Futrakul P, Deekajorndech T Abstract Early stage of vascular disease and diabetic kidney disease (DKD stages 1 and 2) has been under-recognized, under common practice worldwide. The lack of sensitive diagnostic marker leads to late diagnosis and a progression of underlying vascular disease associated with chronic renal ischemia, which eventually intensifies the magnitude of DKD damage. Treatment at this late stage fails to correct the renal ischemia, or restore renal function, due to the altered vascular homeostasis associated with an impaired nitric oxide production. In contrast to...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Glomerular and tubular functions in children with different forms of beta thalassemia.
CONCLUSIONS: Although all types of beta thalassemia patients should be closely monitored to prevent further decrease in renal functions, the patients with TI should be considered to have a higher risk of glomerular and tubular deterioration as well as TM. PMID: 26365703 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of melatonin on diclofenac sodium treated rat kidney: a stereological and histopathological study.
In this study, we aimed to investigate the effect of diclofenac sodium (DS) and melatonin (MEL) on kidney of the prenatally administered rats. MATERIALS AND METHODS: Pregnant rats were divided into the control, physiological saline, DS, and DS + MEL groups. All injections were given beginning from the 5th day after mating to the 15th day of the pregnancy. Physical dissector and Cavalieri principle were used to estimate the numerical density and total number of glomeruli and the volumetric parameters of kidney, respectively. RESULTS: Our stereological results indicated that DS application during the pr...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effects of Panax notoginseng saponins on the cytokines and peritoneal function in rats with peritoneal fibrosis.
CONCLUSION: PNS is capable of improving peritoneal function in subjects with PDF exposure and can possibly applied in patients with PD after further verification. PMID: 26371362 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The use of intravesical hyaluronic acid for recurrent urinary tract infections in children: a case-series study.
CONCLUSIONS: IHA administration is considered as an effective treatment modality which significantly reduces the prevalence of or even provides complete recovery from recurrent UTIs in childhood. Therefore, it is believed that this approach can be used as a promising alternative to widespread use of antibiotics in this patient group. PMID: 26375508 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study.
CONCLUSIONS: SORO-ESRD accounted for 149 (10%) of 1461 incident ESRD patients. There was no gender disparity. The older population was more susceptible. Ninety-nine percent (99%) of SORO-ESRD patients started their first hemodialysis treatment via a dialysis catheter, a major negative impact on AV fistula first programs. ATN was the leading pathologic diagnosis. We conclude that SORO-ESRD contributes significantly to incident ESRD here in the USA including renal allograft loss. Efforts to reduce AKI incidence or renoprevention demand more attention and priority. PMID: 26375630 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Associations among time-average mineral values, mortality and cardiovascular events in hemodialysis patients.
This study examines the associations among mineral values and clinical outcomes from a single medical center. METHODS: Adult patients who initiate hemodialysis in Taoyuan General Hospital from 2008 to 2013 were enrolled. We examined these associations using baseline and time-average model. The clinical outcomes included mortality, major adverse cardiovascular events (MACE) and cardiovascular events. We also examined the association between achieve K/DOQI guidelines' targets and clinical outcomes. RESULTS: From a total of 284 hemodialysis patients, none of the baseline mineral values is associated with mortality and...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Central hemodynamics, vascular stiffness, and nocturia in patients with type 2 diabetes.
In conclusion, central hemodynamic parameters and markers of vascular stiffness may be related with nocturia in patients with T2DM. PMID: 26381594 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study.
Authors: Moraes C, Borges NA, Barboza J, Barros AF, Mafra D Abstract Chronic physical exercises may be beneficial to modulate appetite hormones as acyl-ghrelin (orexigenic) and obestatin (anorexigenic) in chronic kidney disease (CKD) patients; however, there are no data about the effects of acute exercises on these hormones. Thus, the aim of the present study was to assess the effect of acute resistance exercise on appetite hormones (acyl-ghrelin and obestatin) of patients undergoing hemodialysis (HD). Twenty-five patients (44.7 ± 12.9 years, 68% women) on regular HD program were enrolled into ...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Analysis of gene mutations in PKD1/PKD2 by multiplex ligation-dependent probe amplification: some new findings.
Authors: Yu G, Qian X, Wu Y, Li X, Chen J, Xu J, Qi J Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a serious genetic disorder that can lead to chronic renal disease. Protein dysfunction caused by mutations in the genes polycystic kidney disease 1 (PKD1) and polycystic kidney disease 2 (PKD2) is an important factor in the pathogenesis of ADPKD. In the present study, 30 Chinese patients with confirmed diagnosis of ADPKD, based on ultrasound or computerized tomography (CT) findings were selected, and the exon copy numbers of PKD1 and PKD2 were determined using multiplex ligation-dependent probe amp...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

MCP-1 and soluble TWEAK levels are independently associated with coronary artery disease severity in patients with chronic kidney disease.
Authors: Akdoğan MF, Azak A, Denizli N, Huddam B, Koçak G, Gücün M, Tatlısu MA, Demirci R, Yılmaz B, Dikeç M, Bakırtaş M, Akdağ İ, Duranay M Abstract PURPOSE: Patients diagnosed with chronic kidney disease (CKD) have a greater rate of cardiovascular mortality when compared with the general population. The soluble form of TNF-like weak inducer of apoptosis (TWEAK) and monocyte chemoattractan protein 1 (MCP-1) play important roles in cellular proliferation, migration and apoptosis. The current study aimed to analyze whether soluble TWEAK (sTWEAK) and MCP-1 levels are associated with the...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato- and nephrotoxicity in mice.
Authors: Al-Sayed E, Abdel-Daim MM, Kilany OE, Karonen M, Sinkkonen J Abstract The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained from Bauhinia hookeri was investigated against CCl4-induced acute hepatorenal toxicity in mice. BHPF was administered (100, 200 and 400 mg/kg/day) for 5 days, then CCl4 was administered. BHPF pretreatment significantly (p 
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Assessment of fractional excretion of urea for early diagnosis of cardiac surgery associated acute kidney injury.
Authors: Varela CF, Greloni G, Schreck C, Bratti G, Medina A, Marenchino R, Pizarro R, Belziti C, Rosa-Diez G Abstract BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiac surgery (CS). Recently, neutrophil gelatinase-associated lipocalin (NGAL) was shown to predict AKI development earlier than serum creatinine, but it is not widely used in clinical practice. Fractional excretion of urea (FeU) has been referred to as a useful tool to discriminate between prerenal and established AKI. The aim of our study is to evaluate the sensitivity and specificity of FeU, in the early diagnosis of AKI in ...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of two different high-flux dialysis membranes on insulin resistance in non-diabetic end-stage renal disease patients.
CONCLUSION: The two different types of high-flux dialysis membranes used for HD have different effects on insulin sensitivity. Compared to the PS membrane, PPP high-flux membrane decreased insulin resistance by increasing insulin sensitivity among non-diabetic ESRF patients. PMID: 26399977 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Role of ERK1/2 and JNK phosphorylation in iodine contrast agent-induced apoptosis in diabetic rat kidneys.
This study aimed to investigate molecular mechanisms of contrast media-induced apoptosis in diabetic rat kidneys, especially the involvement of ERK1/2 and JNK signal pathways. METHODS: Diabetic Sprague-Dawley rats were induced by intraperitoneal injection of streptozotocin. Ten weeks later the normal and diabetic rats were administered high-osmolar contrast media (HOCM; meglumine diatrizoate) or normal saline (10 mL/kg) injection for 2 consecutive days. At 24 h after the operation, the rats were sacrificed, the blood samples were collected for examining serum creatinine and the kidneys were collected for ...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis.
CONCLUSION: Our results suggest that NAC decreases the incidence of contrast-induced nephropathy among patients with pre-existing renal insufficiency. The benefit was not existed in patients with diabetes. PMID: 26458505 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The effect of music therapy during shockwave lithotripsy on patient relaxation, anxiety, and pain perception.
Authors: Akbas A, Gulpinar MT, Sancak EB, Karakan T, Demirbas A, Utangac MM, Dede O, Sancaktutar AA, Simsek T, Sahin B, Resorlu B Abstract OBJECTIVES: To research the effect of listening to music during shock wave lithotripsy (SWL) on the patient's pain control, anxiety levels, and satisfaction. PATIENTS AND METHODS: The study comprised 400 patients from three hospitals. Half of patients listened to music during their first SWL session but not during their second session. The other half had no music for the first session but the second session was accompanied by music. During all sessions, with and without musi...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Efficacy of triptolide on the apoptosis of tonsillar mononuclear cells from patients with IgA nephropathy.
CONCLUSION: TMCs from IgAN patients may be in a state of inhibited apoptosis mediated by Bcl-2 family proteins, which may be reversed by TP treatment. PMID: 26460503 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The association of urolithiasis and androgenetic alopecia.
CONCLUSIONS: We determined a significant correlation between vertex pattern and total alopecia with urolithiasis in patients younger than 60 years old. PMID: 26460579 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Sulfasalazine-induced renal injury in rats and the protective role of thiol-reductants.
Authors: Heidari R, Taheri V, Rahimi HR, Shirazi Yeganeh B, Niknahad H, Najibi A Abstract Sulfasalazine is widely used for inflammatory-mediated disorders in human. Renal damage is a serious adverse effect accompanied sulfasalazine administration. No specific therapeutic option is available against this complication so far. Oxidative stress seems to play a role in sulfasalazine-induced renal injury. Current investigation was designed to evaluate the effect of N-acetyl cysteine (NAC) and dithiothreitol (DTT) as thiol reductants against sulfasalazine-induced renal injury in rats. Oral administration of sulfasalazine ...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Potential biomarkers for the early detection of acute kidney injury after percutaneous nephrolithotripsy.
This study aims to investigate the role of urinary biomarkers in the determination of the potential risks of renal parenchymal tubular damage in adult patients who underwent percutaneous nephrolithotomy (PNL) with the indication of renal stone. A randomized and prospective controlled study was performed between June and December 2013. We enrolled 29 consecutive patients with renal calculi > 2 cm and who underwent PNL, as well as 47 healthy control subjects. Urine samples, including 2 h before surgery, 2 and 24 h after surgery were collected from the patient group. Freshly voided urine samples were c...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Associations between endothelial nitric oxide synthase polymorphisms and risk of diabetic nephropathy: an updated meta-analysis.
CONCLUSION: Our comprehensive meta-analysis suggests that three polymorphisms of eNOS may be the increased risk factors of DN development, especially in Asian population and T2DM group. PMID: 26489520 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Outcomes of acute kidney injury patients with and without cancer.
Authors: Juwon L, Jang G, Kim S, Kim D, Lee J, Park H, Lee J, Kim S, Kim Y, Kim SY, Yang JW, Gwoo S, Kim YN, Shin HS, Jung Y, Rim H Abstract Incidence of AKI in hospitalized patients with cancer is increasing, but there have been few studies on AKI in patients with cancer. We conducted a retrospective cohort study in a South Korean tertiary care hospital. A total of 2211 consecutive patients (without cancer 61.5%; with cancer 38.5%) were included over a 140-month period. Predictors of all-cause death were examined using the Kaplan-Meier method and the Cox proportional hazards model. The main contributing factors of...
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Readmissions related to antihypertensive medications used in chronic hemodialysis.
CONCLUSIONS: Antihypertensive medications continue to play an important role in the hemodialysis population. This study suggests that drug class and quantity of antihypertensives do not alter readmission rate in the setting of fluid overload. PMID: 26512432 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Grape seed proanthocyanidin extract protects human umbilical vein endothelial cells from indoxyl sulfate-induced injury via ameliorating mitochondrial dysfunction.
CONCLUSION: These results suggest that GSPE prevents HUVECs from indoxyl sulfate-induced injury by ameliorating mitochondrial dysfunction and may be a promising agent for treating uremia toxin-induced injury. PMID: 26512753 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 18, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research