Chronic kidney disease among human immunodeficiency virus positive patients on antiretroviral therapy in sub-Saharan Africa: A systematic review and meta-analysis.
Abstract Human immunodeficiency virus (HIV)-infected patients are at risk for renal disease as a consequence of complications of antiretroviral treatment. Particularly, the complication of kidney disease is high in patients who switched to Tenofovir Disoproxil Fumarate. The treatment is associated with nephrotoxicity, decrease in glomerular filtration rate, leading to kidney disease. This review focused on assessing the effect of antiretroviral therapy (ART) on kidney function among HIV-positive patients. Initially, the study protocol was registered on Prospero and given a unique identification number of CRD420180...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Baynes HW, Negash M, Geremew D, Getaneh Z Tags: Saudi J Kidney Dis Transpl Source Type: research

Continuous renal replacement therapy: Principles, modalities, and prescription.
Abstract The mortality rate of critically ill patients with severe acute kidney injury (AKI) remains high. The associated sepsis and septic shock, as well as the presence of multiorgan failure, further increase the risk of death. Renal replacement therapy (RRT) represents the cornerstone of the management of severe AKI. Continuous RRT (CRRT) has been considered the predominant form of dialysis in the intensive care unit due to its accurate volume control, steady acid-base, and electrolyte correction and achievement of hemodynamic stability. This narrative review covers an introduction to CRRT, its physiologic prin...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Karkar A Tags: Saudi J Kidney Dis Transpl Source Type: research

Quality of life in living kidney donors: A single-center experience at the king abdulaziz medical city.
Abstract Chronic kidney disease (CKD) results in irreversible decline in renal function, which ultimately progresses to end-stage renal disease (ESRD). Transplantation is the treatment of choice for ESRD, and this is possible only if donor kidneys are available. Several doubts can appear in the minds of donors and among general public regarding the quality of life (QOL) after donation which can affect the willingness to donate. Therefore, we aimed to assess the QOL in living kidney donors in King Abdulaziz Medical City, Riyadh, Saudi Arabia using the kidney disease QOL instrument short form (KDQOL-SF). This was a ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Alhussain BM, Alqubaisi AK, Omair A, O'hali WA, Abdullah KO, Altamimi AR Tags: Saudi J Kidney Dis Transpl Source Type: research

Nonadherence to dialysis among saudi patients - Its prevalence, causes, and consequences.
Abstract Dialysis nonadherence among Saudi hemodialysis (HD) patients has not been studied previously. We study its prevalence, causes, and consequences. All chronic HD patients at our center were enrolled. Their demographics as well as levels of hemoglobin (Hb), Kt/v, potassium, and phosphate; dialysis type; dialysis vintage; duration; and shift were recorded. Nonadherence, defined as missed dialysis session or patient-derived shortening of the dialysis session by>10 min at least once over a month's period, was recorded. We analyzed the relationship of nonadherence to emergency room visits, hospitalizations, i...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Alhawery A, Aljaroudi A, Almatar Z, Alqudaimi AA, Al Sayyari AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Peritoneal dialysis for the prevention of fluid overload in infants after cardiac surgery - A systematic review and meta-analysis.
The objective is to compare peritoneal dialysis with standard care therapy for the prevention of fluid overload in infants after cardiac surgery. We searched published literature through the major database up to December 2017. Randomized controlled trials (RCTs), quasi-randomized trials, and observational studies were included in the study. The primary outcome measures were as follows: all-cause mortality and duration of hospitalization. Of the 392-citation retrieved, full text of 7 was finally assessed for eligibility. Of these, a total of five studies (RCTs = 3, and observational studies = 2) were included. There was no ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Bhatt GC, Das RR, Chaudhary B, Satapathy AK, Malik S Tags: Saudi J Kidney Dis Transpl Source Type: research

How informed are the Saudi public about the value of organ donation: A community-based cross-sectional study.
Abstract Organ transplantation is often the ideal option for some end-stage organ diseases. However, organ donation is not keeping pace with growing demand for it. Saudi Arabia has one of the widest gaps between supply and demand with respect to transplants, estimated at 2-4 per million population. The purpose of this study is to survey the public's perceptions and opinion about organ donation and transplants in general. This is a cross-sectional study targeting the age group of 18-60 years as they represent potential organ donors in any community. An Arabic-language questionnaire was distributed online. The quest...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Alnasyan AY, Aldihan KA, Albassam AA, Alhusain FA, Al Tamimi AR Tags: Saudi J Kidney Dis Transpl Source Type: research

Infection associated relapses in children with nephrotic syndrome: A short-term outcome study.
Abstract Children with nephrotic syndrome (NS) encounter multiple episodes of relapses associated/triggered by an episode of infection. The primary objective of this study was to find the proportion of infection associated relapses that resolve on the treatment of acute infection over an observation period of two weeks in children with NS. This prospective observational study enrolled 45 children with steroid-sensitive NS presenting with an infection associated relapse during the study period (February 2015 to February 2016). Baseline information and examination findings of all children were recorded. Biochemical ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Manta M, Singh S Tags: Saudi J Kidney Dis Transpl Source Type: research

The impact of gender matching between donor and recipient on the outcome of kidney transplant patients: A retrospective study.
Abstract The influence of donor and recipient gender on patients postkidney transplant (KT) is still controversial, and literature data do not present unanimous conclusions. We were concerned with the gender impact on the outcome of kidney transplantation at the level of acute rejection (AR), graft function represented by serum creatinine level, delayed graft function (DGF), graft survival, and infection rate. The impact of gender matching between donors and recipients was studied in 299 KT recipients performed in the Transplantation Unit, Middle East Institute of Health, Bsalim, Lebanon, between November 1998 and...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Abou-Jaoude MM, El-Helou E, Nasser HA, Kansoun AH Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparing diabetic and nondiabetic emphysematous pyelonephritis and evaluating predictors of mortality.
Abstract Mortality among patients with emphysematous pyelonephritis (EPN) has reduced from 78% to 21%, yet it is one of the most serious urologic emergencies. This prospective observational study aims to study and compare clinical profile, management, and outcomes in diabetic and nondiabetic patients with EPN. All patients of EPN admitted to emergency medical services were included in the study. Patients were grouped into diabetic and nondiabetic EPN, and the eventual predictors of mortality were assessed. The mean age of patients was 55.43 years, with 36 (65.7%) female patients. Mortality was found to be 18.86%. ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Kamath SU, Patil B, Shelke U, Patwardhan SK Tags: Saudi J Kidney Dis Transpl Source Type: research

Tubulointerstitial nephritis due to sarcoidosis: Clinical, laboratory, and histological features and outcome in a cohort of 24 patients.
We present a retrospective, single-center study of patients followed for sarcoidosis and presenting with TIN related to this systemic disease. Twenty-four patients were assessed (22 females/2 males). The mean age at diagnosis of TIN was 46.3 years. Extrarenal manifestations were dominated by thoracic involvement (95.8%), peripheral lymph nodes (54.2%), and skin lesions (33.3%). The mean proteinuria level was 0.68 g/24 h. Renal failure was diagnosed in 83.3% of cases with a median estimated glomerular filtration rate at 14.3 mL/min/1.73 m2. Nine patients presented with hypercalcemia and 12 patients with hypercalciuria. Rena...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Zammouri A, Barbouch S, Najjar M, Aoudia R, Jaziri F, Kaaroud H, Hedri H, Abderrahim E, Goucha R, Hamida FB, Harzallah A, Abdallah TB Tags: Saudi J Kidney Dis Transpl Source Type: research

The impact of reusable dialyzer membrane on end-stage renal disease patients' Quality of life: A multicenter study in Jakarta, Indonesia.
Abstract Data from 8th Report of the Indonesian Renal Registry in 2015 reported that there was an increase in the prevalence of hemodialysis (HD) patients in Indonesia. Measures had been taken to reduce the cost of HD such as utilizing reusable dialyzer membrane. However, little is known on the impact of reusable dialyzer membrane on patients' quality of life (QOL), and hence, this study was conducted. We conducted a multicenter study at Cipto Mangunkusumo Hospital, Koja District Hospital, and Cengkareng District Hospital with a total of 389 patients. Cipto Mangunkusumo Hospital represented single-use dialyzer gro...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Abdullah Bawazir LA, Marbun MB, Sianipar W, Luthariana L Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of the safety of arteriovenous fistula creation surgery in ambulatory versus inpatient hospital setting.
This study sought to directly compare the rate of complications and postoperative mortality in AVF creation surgeries performed in outpatient and inpatient surgical centers. This multicenter retrospective study recorded emergency department (ED) visits, inpatient admissions, and mortality following 179 outpatient and 146 inpatient AVF surgeries in 2015 and 2016. Rates of mortality at 30 days and ED visits and inpatient admissions at 24-h and seven-day time points were compared in inpatient and outpatient groups. Following outpatient and inpatient surgeries, the rates of inpatient admissions in seven days were 0.685% and 4....
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Margulis R, Pedulla DJ, Bromberg AL, Choice C Tags: Saudi J Kidney Dis Transpl Source Type: research

Noninvasive method of differentiating diabetic nephropathy and nondiabetic renal disease using serum bone morphogenetic protein-7 and transforming growth factor-beta 1 levels in patients with type-2 diabetes mellitus.
Abstract Diabetic nephropathy (DN), one of the major complications of diabetes mellitus, is diagnosed by the presence of pedal edema, 24-h proteinuria>300 mg/day, and retinopathy. However, in view of variable clinical presentations and deviation from the above-said clinical features, it has become difficult to diagnose DN or the presence of nondiabetic renal disease (NDRD). Many biomarkers have been identified which could predict the progression of DN. Despite such advancement in science, it is still difficult to differentiate between DN and NDRD. Diabetes is a state of chronic inflammation. Among the pro-infla...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: John P, Yadla M Tags: Saudi J Kidney Dis Transpl Source Type: research

Risk of diagnostic errors when dealing with aggressive patients: Experimental study.
This study aimed to explore whether aggressive behavior of some patients might affect physicians' clinical reasoning and decision-making. The study was conducted in a format of observation skills clinical examinations (OSCEs). It included simulating patients (SPs) and family physicians in residency training in a clinical setup. The experiment included two arms of dealing with case scenarios with "Neutral" and "Aggressive" behaviors. Explanatory variables assessed were duration of consultation, correct diagnosis, and plan of appropriate management as well as patients' satisfaction. Participants were 14 t...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Al Alwan I, Babiker A, Al Yousif SM, Badri M, Al Haqwi A Tags: Saudi J Kidney Dis Transpl Source Type: research

Arabic translation, adaptation, and validation of the kidney disease quality of life short-form 36.
Abstract The Kidney Disease Quality of Life Short Form 36 (KDQOL-36) is a self-reported measure of health for patients with chronic kidney disease. Our goal was to develop an Arabic version of KDQOL-36 that is linguistically and conceptually equivalent to the original English version. We translated KDQOL-36 into formal Arabic language using forward and backward translation. To assess conceptual equivalence, we administered the Arabic and English versions simultaneously to a group of 10 bilingual patients. To assess test-re-test reliability, we administered the instrument twice to a group of 10 hemodialysis (HD) pa...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Elamin S, E Elbasher AH, E Ali SE, Abu-Aisha H Tags: Saudi J Kidney Dis Transpl Source Type: research

Subjective hemodialysis adequacy can also be measured: Development and psychometric properties evaluation of subjective adequacy questionnaire.
Abstract Long-term prognosis of chronic hemodialysis patients is affected by dialysis adequacy that can have effect on the hemodialysis (HD) outcomes, especially mortality rate. Given the limited knowledge about HD patient's perceptions and experiences about subjective HD adequacy (SHA) and the lack of SHA measuring questionnaire (SHAMQ), this study was conducted with the aim of developing the SHAMQ and evaluating its psychometric properties based on the operational definition of SAH concept. This mixed-method sequential exploratory design study was conducted from 2016 to 2018 in eight HD units of Mashhad, Iran. I...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Biniaz V, Moonaghi HK, Froutan R, Ebadi A Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison of sleep quality and dialysis adequacy of patients undergoing hemodialysis.
This study was carried out to investigate the correlation between sleep quality and dialysis adequacy in hemodialysis (HD) patients on a population and sample consisting of 50 patients receiving HD treatment at a training and research hospital in Amasya. Data were collected using "Patient Information Form," "Pittsburgh Sleep Quality Index (PSQI)," and "Good Dialysis Index (GDI)." Sleep patterns of patients during HD were observed and recorded for three weeks. The average age was 64.46 years (minimum: 22, maximum: 86; standard deviation: 14.612), 56% (n = 28) are women, 64% (n = 32) are married...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Terzi B, Topbaş E, Ergül HÇ Tags: Saudi J Kidney Dis Transpl Source Type: research

Risk factors and short-term outcomes for methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus colonization among hemodialysis patients.
Abstract Patients with end-stage renal disease are susceptible to infection, particularly methicillin-resistant Staphylococcus aureus (MRSA). Although MRSA-related mortality and morbidity have been studied, methicillin-sensitive Staphylococcus aureus (MSSA) has not been investigated to the same degree. Five hundred and seventy-eight chronic hemodialysis patients were followed up retrospectively for 18 months. Routine screening for MRSA and MSSA was instigated. Two hundred and eighty-eight patients (49%) had at least one positive MSSA or MRSA swab. There was no statistical difference in age, Charlson index, diabete...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Price AM, Sarween N, Gupta I, Baharani J Tags: Saudi J Kidney Dis Transpl Source Type: research

Superior protective effects of febuxostat plus alpha-lipoic acid on renal ischemia/reperfusion-induced hepatorenal injury in rats.
This study was performed to evaluate the effects of febuxostat (FEB), a selective xanthine oxidase (XO) inhibitor, and alpha-lipoic acid (ALA), a strong antioxidant, on the kidney and liver changes induced by renal I/R in rats. Renal I/R was induced in rats by clamping renal pedicles for 1 h followed by 2 h reperfusion. Fifty rats were assigned to five groups as follows: sham operated; vehicle + I/R; FEB + I/R; ALA + I/R, and (FEB + ALA) + I/R. Drug treatment was given 24 h and 1 h before I/R induction. Serum and tissue biochemical parameters and histopathological changes were examined after reperfusion. Serum creatinine, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Farag MM, Ahmed SM, Elhadidy WF, Rashad RM Tags: Saudi J Kidney Dis Transpl Source Type: research

Determinants of medical students for intention to organ donation: Application of theory of planned behavior.
Abstract Organ donation and transplantation save thousands of lives in the world. The aim of this study was identifying determinants of organ donation intention based on the Theory of Planned Behavior (TPB) among Iranian Medical Students. This cross-sectional study was performed during 2017 in Shahid Beheshti University of Medical Sciences. A sample of 438 students of Shahid Beheshti University of Medical Sciences was selected using multi-stage sampling method including stratified and random sampling. Data were collected by using a reliable and valid TPB-based questionnaire. All the participants filled the questio...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Ghaffari M, Rakhshanderou S, Najafizadeh K, Ramezankhani A, Latifi M Tags: Saudi J Kidney Dis Transpl Source Type: research

Chemerin level and the relation to insulin resistance in chronic kidney disease.
This study was conducted on 80 participants who were classified into three groups: Group I (30 CKD patients with mean age 53 ± 12 years), Group II (30 patients with end-stage renal disease on regular hemodialysis with mean age 48 ± 14.8 years) and Group III having 20 healthy age-and sex-matched controls. Serum chemerin level, fasting blood sugar, fasting insulin, HOMA-IR index calculation, urea, creatinine, estimated glomerular filtration rate, total cholesterol, and triglyceride were measured. Body composition was assessed by dual-energy X-ray absorptiometry. In Groups I and II, we found a significantly high...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: El-Khashab SO, Gamil M, Ali AY, El-Khashab O, El-Khatib M, Mohamed K, El-Shehaby A, Hamed ST Tags: Saudi J Kidney Dis Transpl Source Type: research

Vitamin-D deficiency is encountered in almost all egyptian stage 3-5 chronic kidney disease patients in spite of the sunny weather.
Abstract Currently, there is no available data about Vitamin D status among Egyptian chronic kidney disease (CKD) patients. This cross-sectional study is looking for the prevalence of Vitamin D deficiency among Stage 3a-5 CKD Egyptian patients and its possible associations. We studied 1624 Stage 3a-5 CKD adults (689 males and 935 females) together with 200 normal control persons. All the recruited candidates were tested for body mass index (BMI); serum levels of blood urea nitrogen, creatinine, calcium (Ca), phosphorus (P), parathyroid hormone (PTH), 25 hydroxy vitamin D (25(OH)D), albumin, and uric acid (UA); uri...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: El Din US, Fayed A, El Nokeety MM, Abdulazim DO, Salem MM, Vascular Calcification Group Tags: Saudi J Kidney Dis Transpl Source Type: research

Prospective nonrandomized study with early steroid withdrawal (Day 5) postrenal transplant in low immunological risk patients: A singlecenter experience at prince sultan military medical city Riyadh.
Abstract Steroids remain an essential part of immunosuppressive therapy for renal transplant patients since the start of transplant era. Different immunosuppressive regimens are prescribed so as to minimize the side effects. The purpose of our study is to compare the outcome of early steroid withdrawal with steroid maintenance protocol. It is a prospective nonrandomized study. All patients that received renal transplants from January 2011 to December 2013 were included in the study. Early steroid withdrawal at day 5 was done in low immunological risk patients, and the results were compared with the steroid mainten...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Zahir N, Mousa D, Al Taweel A, Ashraf A, Fahim A, Taqi K, Zahid R, Aslam N Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute interstitial nephritis in the military hospital of Morocco: Clinical features and renal outcomes.
In this study, a good outcome was associated with autoimmune diseases (P = 0.02) and with a higher intensity of interstitial edema (P = 0.01). However, a presence of a granuloma (P = 0.04), a higher percentage of interstitial fibrosis (P
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Zajjari Y, Montasser D, Sobhi A, Aatif T, Azizi M, Alayoud A, El Kabbaj D Tags: Saudi J Kidney Dis Transpl Source Type: research

Bone mineral density in children with relapsing nephrotic syndrome: A hospital-based study.
Abstract This cross-sectional analytical study was conducted from January 2012 to November 2014 in the Department of Pediatric Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, to evaluate the bone mineral density (BMD) values in children with relapsing nephrotic syndrome (NS). Thirty relapsing nephrotic patients were enrolled in this study. They were divided into two groups: Group I - Frequent Relapse (FR) with 21 patients and Group II - Infrequent Relapse (IFR) with nine patients. Children included were both males and females aged between four and 15 years with relapsing NS with normal ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Jesmin T, Al Mamun A, Rahman MA, Santa SM, Huque SS, Begum A, Roy RR, Rahman MH, Uddin GM Tags: Saudi J Kidney Dis Transpl Source Type: research

Pregnancy-related acute kidney injury: Etiologies and short-term outcomes in a tertiary hospital in Southwest Nigeria.
Abstract Although the incidence of pregnancy-related acute kidney injury (PRAKI) is declining in developing countries, it still remains a major cause of maternal and fetal morbidity and mortality. The aim of this study was to determine the etiologies, short-term outcomes, and their predictors in patients with PRAKI managed in a tertiary health facility in Southwest Nigeria over a four-year period. This was a four-year retrospective review of clinical records of patients managed for PRAKI in University of Medical Sciences Teaching Hospital, Ondo State, Nigeria. Thirty-two women with a mean age of 31.09 ± 7.5...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Adejumo OA, Akinbodewa AA, Enikuomehin OC, Lawal OM, Abolarin OS, Alli OE Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and risk factors of chronic kidney disease in overweight and obese population in a tertiary care hospital in North India.
Abstract Obesity has already been a global epidemic, and its prevalence has been projected to grow by 40% in the next decade. Its increasing prevalence has implications on the epidemiology of chronic kidney disease (CKD), which, in turn, could impact the health system and thereby the society in an adverse manner. Lack of community-based screening programs can lead to missed or late detection of CKD. The current study aims to estimate the prevalence of CKD in overweight and obese general population attending a screening camp in a tertiary care hospital in a North Indian city. In this cross-sectional study, 103 over...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Rai PK, Rai P, Bedi S Tags: Saudi J Kidney Dis Transpl Source Type: research

Women donate, men receive: gender disparity among renal donors.
Abstract In living donor kidney transplantation, a predominance of female-to-male donations has been observed. This gender disparity is more so in developing countries and requires targeted counseling and research to understand whether the cause is medical or sociocultural obstacles. The aim of this study was to analyze all living donor kidney transplants performed at a tertiary care center catering to patients of varied socioeconomic backgrounds. This was a retrospective cohort study of all 600 kidney donors who underwent donor nephrectomy at a single transplant center, Mahatma Gandhi Hospital, Jaipur, between 20...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Godara S, Jeswani J Tags: Saudi J Kidney Dis Transpl Source Type: research

A rare case of autosomal recessive ATP6V0A4 variant of distal renal tubular acidosis in a young female with recurrent nephrolithiasis.
We report the case of a 30-year-old married woman diagnosed with dRTA at three months of age with mild SNHL, showing homogygous nonsense mutation in exon 3 of the ATP6V0A4 gene that resulted in a stop codon and premature truncation of the protein at codon 6. PMID: 31929293 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Anupama PH, Abraham G, Shanmugasundaram L, Anupama SH Tags: Saudi J Kidney Dis Transpl Source Type: research

Tuberculosis as a microbiologically proven etiology of membranous nephropathy and interstitial nephritis.
We report the first case of microbiologically proven tubercular interstitial nephritis and membranous nephropathy (MN) occurring concurrently in the same patient. The patient improved with the use of antitubercular therapy alone. TB should be recognized as a potentially treatable infectious cause of secondary MN. PMID: 31929294 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Malhotra KP, Chandra A, Rao N, Shukla S, Gupta A Tags: Saudi J Kidney Dis Transpl Source Type: research

Epidermolysis bullosa complicated with nephrotic syndrome due to AA amyloidosis: A case report and brief review of literature.
;n H, Düşünsel R Abstract Epidermolysis bullosa (EB) encompasses a clinically and genetically heterogeneous group of rare inherited diseases characterized by marked mechanical fragility of epithelial tissues with blistering and erosions following minor trauma. Amyloidosis is one of the most important complications of EB mostly seen in recessive dystrophic EB (RDEB) patients and can involve the kidney, bowel, liver, and also respiratory system. Herein, we present a child, who is probably the youngest case of genetically diagnosed RDEB, complicated with amyloidosis reported in literature. A 6-year-old boy...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Pınarbaşı AS, Dursun I, Daldaban B, Günay N, Çiçek S, Şahin N, Yel S, Poyrazoglu MH, Akgün H, Düşünsel R Tags: Saudi J Kidney Dis Transpl Source Type: research

C1q nephropathy developing in a case of gastric carcinoma.
Abstract C1q is a key intermediary in the classical complement pathway. It is known to be activated by several factors including immunoglobulins and charged molecules and is an initiator of the complement cascade. C1q nephropathy (C1qN) is a rare idiopathic glomerulonephritis characterized by predominant presence of glomerular deposits of C1q fraction of complement. Although few uncommon associations of C1qN have been seen with various disorders, we present the first case of C1qN diagnosed in an elderly male with gastric adenocarcinoma. Few months after the onset of symptoms related to gastric-outlet obstruction, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Malhotra KP, Chandra A, Shukla S, Yadav A, Husain N Tags: Saudi J Kidney Dis Transpl Source Type: research

Toxocariasis and nephrotic syndrome.
We describe a case of toxocariasis as a rare cause of nephrotic syndrome in an adult woman. This rare association was confirmed by elevated Toxocara-specific immunoglobulin M titers. Renal biopsy was not done because of prolonged activated partial thromboplastin time. Our patient was treated with prednisone and albendazole. These treatments resulted in partial remission of renal symptoms as well as the abatement of the Toxocariasis infection. The relationship between toxocariasis infection and glomerular disease is still unclear. In the literature, exceptional renal impairment secondary to toxocariasis have been described,...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Ariba YB, Abid R, Battikh R, Louzir B, Labidi J Tags: Saudi J Kidney Dis Transpl Source Type: research

Late occurrence of pelvi-ureteric junction obstruction in renal allograft and live-related kidney donor.
Abstract Pelvi-ureteric junction (PUJ) obstruction is an enigmatic condition. While in a reasonable majority it is clear cut, the diagnosis and the need for intervention in the remainder is still a challenge. We would like to share the details of two cases, one in a transplant recipient and the other in a living kidney donor, and propose an explanation as to why PUJ obstruction becomes manifest after such a long period of time. In this presentation, we would like to propose that forced drinking of fluids by patients who have an equivocal PUJ and a single kidney could tilt the balance resulting in overt PUJ obstruc...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: George K, Gopalakrishnan G, Al-Mamari SA, Viswaroop SB Tags: Saudi J Kidney Dis Transpl Source Type: research

Simultaneous tubular and glomerular involvement with cryoglobulinemia vasculitis in multiple myeloma.
We report a case of multiple myeloma with systemic manifestation of Type-1 cryoglobulinemic vasculitis (skin rash and polyarthritis) and unusual renal manifestation with both tubular and glomerular involvement on renal biopsy along with features of cryoglobulinemic renal vasculitis. Renal biopsy showed light chain cast nephropathy and glomerular involvement. Glomeruli displayed membranoproliferative pattern with monoclonal immunoglobulin deposition disease and features of cryoglobuminemia. Immunoflourescence showed Kappa restriction in the tubular casts and glomerular deposits. Serum light chain assay and immunoelectrophor...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Zahir Z, Agrawal V, Wani AS, Prasad N Tags: Saudi J Kidney Dis Transpl Source Type: research

Multiple Loculated Peritoneal Abscesses in a Child with Nephrotic Syndrome: A Rare Presentation.
Abstract Infection in nephrotic syndrome (NS) is an important cause of mortality and morbidity, especially during corticosteroid therapy. Delayed diagnosis and treatment of these infections can result in some severe consequences. Common infections are peritonitis, meningitis, pneumonitis, and cellulitis. They may even cause abdominal abscess formation. Although literature review reveals abdominal abscesses in NS, multiple loculated peritoneal abscesses are rare in childhood NS. Here, we report a case of multiple loculated peritoneal abscesses in an 8-year-old male child with NS. PMID: 31929300 [PubMed - in pr...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Rahman MA, Rahman MH, Karim MR, Huque SS Tags: Saudi J Kidney Dis Transpl Source Type: research

Simultaneous acute pancreatitis and angioedema associated with angiotensin-converting enzyme inhibitor.
Abstract Angiotensin-converting enzyme inhibitors (ACEI) are commonly prescribed drugs for blood pressure (BP) control and renal protection. The use of ACEI is not associated with an increased risk of acute pancreatitis and ACEI-induced angioedema is rare. A 36-year-old woman presented with vomiting, headache, and aphasia. Her BP was 220/100 mm Hg. urine analysis revealed proteinuria (2+), hematuria (3+). Serum creatinine level was at 1125 μmol/L. She had anemia with 6.1 g/dL of hemoglobin and thrombocytopenia (61,000/mm3). Renal histology revealed lesions of thrombotic microangiopathy. The diagnosis of atypica...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Gorsane I, Ayed TB, Aoudia R, Kaaroud H, Hamida FB, Harzallah A, Abdallah TB Tags: Saudi J Kidney Dis Transpl Source Type: research

Emphysematous Pyelonephritis.
PMID: 31929302 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Cavol GL, Finazzo F, Carollo C, Li Cavoli TV, Zagarrigo C, Azzolina V, Mongiovi R, Amato A, Oliva B, Servillo F, Tortorici C, Schillaci O, Tralongo A, Turdo R, Bono L, Giammarresi C, Caputo F Tags: Saudi J Kidney Dis Transpl Source Type: research

Spontaneous internal oblique and transverse abdominal muscle hematoma in a patient undergoing peritoneal dialysis.
PMID: 31929303 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Matsuyama M, Morino J, Minato S, Kaneko S, Yanai K, Mutsuyoshi Y, Ishii H, Kitano T, Miyazawa H, Aomatsu A, Ueda Y, Ito K, Hirai K, Hoshino T, Ookawara S, Morishita Y Tags: Saudi J Kidney Dis Transpl Source Type: research

Decreased tacrolimus concentration due to Campylobacter colitis.
PMID: 31929304 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Akanuma T, Ochi A, Inoue T, Okada D, Abe H, Kuji H, Suzuki T Tags: Saudi J Kidney Dis Transpl Source Type: research

Kidney transplantation among patients with severe mental illness.
PMID: 31929305 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2019 Category: Urology & Nephrology Authors: Uvais NA, Hafeeq B, Aziz F Tags: Saudi J Kidney Dis Transpl Source Type: research

Vaccine-associated kidney diseases: A narrative review of the literature.
Abstract Immunization is one of the greatest public health achievements of the 20th century. Vaccines have enabled the eradication of deadly diseases and decreased the morbidity and mortality associated with various infections. Most vaccines are safe to administer and cause only minor side effects. Although very rare, various glomerular diseases and acute kidney injury have been reported following immunization with certain vaccines including influenza, pneumococcal, and hepatitis B vaccines. This review summarizes these rare renal complications that have been published in the literature. Physicians and other healt...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Patel C, Shah HH Tags: Saudi J Kidney Dis Transpl Source Type: research

Serum fibroblast growth factor 23 levels do not correlate with carotid intima-media thickness in patients with chronic kidney disease.
This study aimed to investigate the relationship between serum FGF23 levels and CIMT of CKD patients. In this cross-sectional study, CIMT was measured in 162 patients with CKD Stage of 2-5 (age range 18-79 years, 61.7% males). Serum FGF23 levels were determined by enzyme-linked immunosorbent assay. CIMT was measured by ultrasonography. Serum FGF-23 levels were significantly higher (P = 0.046) in advanced CKD patients. CIMT was thicker in patients with advanced CKD patients (P = 0.01). CIMT was correlated with age (r = 0.486, P
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Kaya B, Seyrek N, Paydas S, Karayaylali İ, Balal M, Aikimbaev K Tags: Saudi J Kidney Dis Transpl Source Type: research

Correlation between serum sclerostin level and bone density status in children on regular hemodialysis.
Abstract Bone disease is frequently observed in chronic kidney disease (CKD) and increases a patient's risk for fracture. Sclerostin is an osteocyte-derived negative regulator of bone formation. We aimed to assess serum sclerostin level as a bone marker in children with CKD on regular hemodialysis (HD) and detect the association between this and bone density status. This cross-sectional comparative study was conducted on 25 children with CKD on HD and 25 age- and sex-matched healthy children, as controls. Their ages ranged from 4 to 18 years. Serum sclerostin levels were measured and dual-energy X-ray absorptiomet...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Elsalam MA, El-Abden MZ, Mahmoud E, Zahab ZA, Ahmed H Tags: Saudi J Kidney Dis Transpl Source Type: research

Effects and association of pro-oxidants with magnesium in patients with diabetic nephropathy.
In this study, we estimated the levels of Mg, which is an important trace element and pro-oxidant marker, and then evaluated the association between serum Mg and pro-oxidants in patients with DN. In the present study, 200 patients were enrolled and were divided into two groups. The control and DN groups consisted of 100 healthy individuals and 100 patients with DN, respectively. Serum Mg, total anti-oxidant capacity (TAC), and superoxide dismutase (SOD) levels were estimated using the Calmagite, Koracevic, and Marklund and Marklund methods, respectively. Glutathione (GSH) and malondialdehyde (MDA) levels were estimated usi...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Kachhawa K, Kachhawa P, Agrawal D, Kumar S, Sarkar PD Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of blood pressure profile in chronic hemodialysis patients using two measurement methods: Home blood pressure measurement and conventional measurement.
Abstract The monitoring of hypertension (HTN) in dialysis is often delicate with potentially false measurements due to the white coat effect on the one hand and masked HTN (M-HTN) on the other hand. In this population, there is much controversy over the ideal moment for taking blood pressure (BP) and the target values. An answer to these questions is given by home BP measurement that can detect white coat HTN (WC-HTN) and M-HTN. The aim of this study was to determine the respective prevalence of permanent HTN (P-HTN), WC-HTN, M-HTN, and permanently normotensive (P-NTN) in this population and to analyze the risk fa...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Faye M, Faye M, Lemrabott AT, Cisse MM, Fall K, Ismael Keita AR, Mbengue M, Ba B, Keita N, Diagne S, Niang A, Diouf B, Ka EHF Tags: Saudi J Kidney Dis Transpl Source Type: research

Prediction of mortality and need for renal replacement therapy in patients of acute kidney injury using fibroblast growth factor 23.
Abstract Acute kidney injury (AKI) occurs in up to 50% of patients admitted to the intensive care units. Fibroblast growth factor 23 (FGF23), which plays an important role in regulating phosphate, rises early in AKI. Few studies were conducted to correlate the level of FGF23 and adverse outcomes in AKI. The study was conducted on 30 participants with AKI, which was defined according to AKI network criteria, admitted to the Critical Care Department, Kasr El Aini Hospital, Cairo University between July 2016 and May 2017, and serum FGF23 was measured within 24 h of AKI onset to correlate the level of FGF23 with morta...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Fayed A, Radwan WA, Amin M, Gamal A Tags: Saudi J Kidney Dis Transpl Source Type: research

The characteristics of patients returning to hemodialysis due to nonfunctioning graft in Turkey.
Abstract Renal transplantation is the most effective treatment modality for end-stage renal failure. According to the Ministry of Health Organ Transplant Registration System, despite the presence of 14,936 renal transplant recipients in Turkey, there are not enough data about the prognosis of these patients. Therefore, we aimed to ascertain the rate of patients returning to hemodialysis (HD) due to nonfunctioning graft in our country. One thousand four hundred and ninety-eight (males: 826, females: 672) HD patients who undergo HD at 22 HD centers in total, from different geographical regions to represent our count...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Altun I, Selcuk NY, Baloglu I, Turkmen K, Tonbul HZ Tags: Saudi J Kidney Dis Transpl Source Type: research

Prediction model for successful radiocephalic arteriovenous fistula creation in patients with diabetic nephropathy.
This study was conducted at a tertiary care teaching hospital of South India. Patients with ESRD due to diabetic nephropathy whom underwent left radiocephalic AVF at wrist were enrolled. Risk factors for primary failure were analyzed by univariate and multivariate logistic regression models. Sixty-six patients were included in the study. Thirty-one patients had a primary failure. Independent risk factors for primary failure were palpable vessel wall of the radial artery (P = 0.003, odds ratio [OR] = 15.317), smaller radial artery diameter (P = 0.001, OR = 16.526), radial artery peak systolic velocity (PSV)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Kumar JS, Sajeev Kumar KS, Arun Thomas ET, Hareesh KG, George J Tags: Saudi J Kidney Dis Transpl Source Type: research

Long-term renal outcome and survival of kidney transplant recipients admitted to the intensive care unit.
Abstract The goal of this study was to evaluate the course and outcome of kidney transplant (KT) recipients admitted to the intensive care unit (ICU). We reviewed the data of all adult renal transplant recipients who are admitted to the ICU at our center, between 1997 and 2017. Data reviewed included the demographic features, causes of end-stage renal disease, causes of admission, time between transplantation and admission, and ICU course and outcome. Among 379 KT recipients followed up in our center, 60 patients were admitted to the ICU and were categorized to early (during first 90 days; n = 28); intermediate (3...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: El-Agroudy AE, Alqahtani AM, Dandi B, Farid E, Alaradhi A Tags: Saudi J Kidney Dis Transpl Source Type: research