Pregnancy-associated hemolytic uremic syndrome
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1180-1188. doi: 10.4103/1319-2442.308326.ABSTRACTPregnancy-associated hemolytic uremic syndrome (P-aHUS) is not an uncommon condition. It is considered a medical emergency that is associated with a high risk of mortality and serious morbidity. End-stage renal disease as a consequence of P-aHUS occurs in>50% of the patients if left untreated; the majority of identified cases (79%) are during the postpartum period. Its mechanism of action is related mainly to the disturbance in the activation of the complement alternative pathway, leading to damage of the microvascular endoth...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Sami Alobaidi Ammar AlDabbagh Amany Alamoudi Murad Almowarey Ahmed Akl Source Type: research

Genetic screening in children with challenging nephrotic syndrome
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1189-1197. doi: 10.4103/1319-2442.308327.ABSTRACTGenetic screening paradigms for the nephrotic syndrome (NS) in the developed world are well established; however, screening in developing countries has received only minor attention. We retrospectively analyzed a cohort of all children who underwent genetic testing for challenging NS from our registry in the 10-year interval from 2000 to 2010 and based on 58 patients aged 0-12 years with at least one of the following clinical diagnosis: Nonsyndromic steroid-resistant nephrotic syndrome (SRNS), familial NS, and congenital NS. Of ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Bassam Saeed Source Type: research

Urinary podocalyxin: Is it a real index of disease activity in egyptian patients lupus nephritis?
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1198-1205. doi: 10.4103/1319-2442.308328.ABSTRACTSystemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by production of a number of antinuclear antibodies. Podocyte injury is an important feature and can be detected by several markers including podocalyxin. We aimed to evaluate the impact of SLE on urinary levels of podocalyxin and to determine its relationship to renal biopsy, proteinuria, and disease activity in lupus nephritis (LN) patients. Sixty individuals were recruited; 30 SLE patients with LN as well as 30 healthy volunteers and they w...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Ahmed Fayed Mahmoud M Elnokeety Mohamed Elyamny Hany Hammad Dina Hesham Ahmed Soliman Reham Abdelghany Ahmed Source Type: research

Interleukin 18 as a new inflammatory mediator in left ventricular hypertrophy in children with end-stage renal disease
This study shows that elevated hsCRP and IL-18 are independent determinants of LVH in HD children. Understanding the role of inflammatory molecules in the pathogenesis of LVH in ESRD is important for prediction of high-risk group and implementation of targeted anti-inflammatory therapies.PMID:33565432 | DOI:10.4103/1319-2442.308329 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Ahlam Badawy Dalia A Nigm Ghada M Ezzat Yasser Gamal Source Type: research

Causes of the delay in creating permanent vascular access in hemodialysis patients
This study aims to identify the physicians' perspectives regarding the reasons of delayed arteriovenous fistula (AVF) creation in the Kingdom of Saudi Arabia to improve the quality of CKD patients' care and prognosis and prevent complications. A cross-sectional descriptive study was conducted on KSA nephrologists using a questionnaire which includes factors associated with delay in AVF creation, which were categorized into patient, physician, and hospital factors. The optimal timing of starting dialysis was also assessed. In a total of 212 participants, 131 (61.8%) were of consultant level, with the largest numbers being f...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Maha A Alfarhan Shahad A Almatrafi Sumaia M Alqaseer Yara A Albkiry Abdulla AlSayyari Source Type: research

A study of quality of life among hemodialysis patients and its associated factors using kidney disease quality of life instrument-SF36 in Riyadh, Saudi Arabia
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1225-1233. doi: 10.4103/1319-2442.308331.ABSTRACTWe aimed in this study to assess the quality of life for kidney-ill patients using Kidney Disease Quality of Life Instrument-SF36 (KDQOL-SF36) and the impact of other demographic, clinical, and social factors on patients' QOL. The quality of life was assessed using an Arabic version of KDQOL-36. The KDQOL-36 subscales Physical Component Summary (PCS), Mental Component Summary (MCS), Burden of Kidney Disease, and Effects of Kidney Disease were calculated. The effect of sex, diabetic status, diabetes mellitus, marital and status e...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Abdulaziz Ajeebi Abdulkarim Saeed Alwaleed Aljamaan Mujahid Alshehri Majed Nasradeen Nouf Alharbi Aamir Omair Abdulla A Al-Sayyari Source Type: research

Echocardiographic findings in children with chronic kidney disease
This study aims to determine the incidence of CVD in children with CKD, to analyze risk factors and early predictors for late onset atherosclerosis. Thirty-five CKD children [25 on regular hemodialysis (HD) and 10 on conservative management] were evaluated clinically. Left ventricular (LV) functions and carotid artery intima-media thickness (c-IMT) were assessed using conventional echocardiography, pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI). There was decreased E/A ratio and increased E/E' ratio in 66% and 77% of patients, respectively signifying diastolic cardiac dysfunction. There was a significant correl...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Bahia Moustafa Hanan Zekry Rania Hamdi Hashim Doaa Mohamed Salah Ahmed Abdelwahed Abdelfattah Rodina Sobhy Source Type: research

Evaluation of visual evoked potentials and brain-stem auditory evoked response in patients of chronic kidney disease
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1245-1253. doi: 10.4103/1319-2442.308333.ABSTRACTChronic kidney disease (CKD) is associated with functional changes in the central nervous system (CNS) which, in the initial stages do not manifest clinically. Early involvement of the CNS can be identified by the assessment of the electrocortical activity. Visual evoked potential (VEP) and brain-stem auditory evoked response (BAER) are useful tests for the early diagnosis of CNS involvement in CKD and are more sensitive compared to electroencephalography. One hundred adult CKD patients (stage 3-5 and 5D) and 50 controls were in...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: H K Aggarwal Deepak Jain Shailesh Bhatia Source Type: research

Significance of ambulatory blood pressure monitoring in assessment of potential living kidney donors
In conclusion, ABPM is a reliable modality for the identification of masked HTN and white coat HTN. Masked HTN is correlated with increased risk of end organ damage and risk of death in potential kidney donors. Transplant physicians cannot rely solely on office BP monitoring in the assessment of potential living kidney donors. ABPM should be integral part of routine assessment of potential living kidney donors.PMID:33565437 | DOI:10.4103/1319-2442.308334 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Niamh M Brady Hatem Ali Fiona Biggins Aimun Ahmed Source Type: research

Diagnosis of iron deficiency in hemodialysis patients: Usefulness of measuring reticulocyte hemoglobin equivalent
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1263-1272. doi: 10.4103/1319-2442.308335.ABSTRACTThe evaluation of iron status in dialysis patients provides information essential to the planning of adequate recombinant human erythropoietin treatment. To diagnose iron deficiency in patients undergoing hemodialysis (HD), reticulocyte hemoglobin content and percentage of hypochromic red cells are incorporated into the European best practice guidelines on anemia management in chronic kidney disease (CKD), the mean reticulocyte hemoglobin content (Ret-HE) was proposed as alternatives to standard biochemical tests. Reticulocyte h...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Dawlat Sany Yasser El Shahawi Jenan Taha Source Type: research

Validation of acute kidney injury prediction scores in critically ill patients
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1273-1280. doi: 10.4103/1319-2442.308336.ABSTRACTPrediction of acute kidney injury (AKI) in critically ill patients allows prompt intervention that improves outcome. We aimed for external validation of two AKI prediction scores that can be bedside calculated. A prospective observational study included patients admitted to medical and surgical critical care units. Performance of two AKI prediction scores, Malhotra score and acute kidney injury prediction score (APS), was assessed for their ability to predict AKI. The best cutoff point for each score was determined by Youden ind...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Ahmed Mohamed Zahran Yasser Ibrahim Fathy Asmaa Esmail Salama Mohamed Esam Alebsawi Source Type: research

Blood pressure standards for pre-school children in Saudi Arabia
This study adds evidence to the BP variations between populations with influences such as genetic and environmental factors. The need of every population to define its normal BP standards is essential to avoid unnecessary investigations and anxiety in patients and their parents.PMID:33565440 | DOI:10.4103/1319-2442.308337 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Abdullah A Al Salloum Mohammed I El Mouzan Ahmad H Al Sharqawi Ahmad A Al Omar Mansour M Alqurashi Abdullah S Al Herbish Source Type: research

Experiences of stress appraisal in hemodialysis patients: A theory-guided qualitative content analysis
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1294-1302. doi: 10.4103/1319-2442.308338.ABSTRACTChronic renal failure and prolonged hospitalization for the treatment of renal disease incur immense stress and anxiety in patients. Considering the increased prevalence of renal failure, the present study aimed to explain the experiences of stress assessment in hemodialysis (HD) patients based on the transactional model of Lazarus and Folkman. The data collection method was semi-structured interview with 22 patients from dialysis centers in Tehran. Sampling was purposive and continued until data saturation. Data were analyzed u...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Mohammad Ali Morowatisharifabad Mohtasham Ghaffari Yadolah Mehrabi Jafar Askari Samad Zare Somayeh Alizadeh Source Type: research

Myringosclerosis in hemodialysis patients with hyperparathyroidism
This study is aimed to detect the prevalence of myringosclerosis in patients of our hemodialysis (HD) unit and find out any association between hyperparathyroidism and myringosclerosis in chronic HD patients. A total number of 86 patients were selected according to the inclusion criteria. They were divided into two groups: Group 1 (58 patients myringosclerosis free patients on regular HD), Group 2 (28 patients myringosclerosis-positive patients on regular HD). No statically significant difference was found in serum parathyroid hormone levels between the two studied groups. Serum creatinine was significantly higher in Group...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Alsayed Alnahal Mohamed Waheed Walid Ahmed Ragab Abdelhamid Source Type: research

The protective effect of alpha-lipoic acid on the expression of collagen IV, renal function, and oxidative stress induced by diazinon in the renal parenchyma of rat
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1310-1319. doi: 10.4103/1319-2442.308340.ABSTRACTDiazinon (DZN) is an organophosphate pesticide that is commonly used in agriculture worldwide, including in Iran, and unfortunately, it leads to a variety of negative effects on the environment, animals, and humans. Alpha-lipoic acid (ALA) is an antioxidant agent that acts via scavenging of oxygen-free radicals. Collagen IV is a component of the main base membrane structure and DZN may also affect the expression of this key protein. The aim of this study was to evaluate antioxidant properties of ALA on the expression of collagen...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Amir Delavar Mohammad Reza Nikravesh Mehdi Jalali Mahmoud Gorji Valokola Fatemeh Rahimi Anbarkeh Source Type: research

Serum cystatin C unmasks renal dysfunction in cirrhosis and performs better in estimation of glomerular filtration rate
In this study, we aimed to measure glomerular filtration rate (mGFR) using 99Tc DTPA in patients with Child-Pugh C cirrhosis and normal serum creatinine levels; and to compare the performance of creatinine and cystatin C-based equations [estimated GFRs (eGFRs)] to 99TcDTPA GFR in the same group. We selected a group of 65 consecutive patients with advanced liver cirrhosis and apparently normal renal function by serum creatinine alone. Patients with confounding and reversible factors were excluded. Demographic data, blood, urine, and imaging tests along with simultaneous measurement of serum creatinine and cystatin C were an...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Balaraman Velayudham Remi George Thomas C Vasudevan R P Senthilkumar None Thirumalvalavan None Murugesan Source Type: research

Thrombotic microangiopathy in a renal allograft: Single-center five-year experience
We present 5-year experience of TMA in RT in retrospective study of indicated renal allograft biopsies with TMA. Patient-donor demographics and associated histological findings with respect to transplants under tolerance induction protocol (Group 1) were compared with patients transplanted under triple immunosuppression (Group 2). Statistical analysis was performed using IBM SPSS Statistics version 20. Sixty-one (4.1%) of 1520 biopsies [Group 1:17 (1.9%)/882, Group 2:44 (6.9%)/638] revealed TMA. Tacrolimus trough levels were normal. There was no evidence of systemic involvement in any patient. Mean age was 36.8 years with ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Aruna V Vanikar Kamal V Kanodia Kamlesh S Suthar Lovelesh A Nigam Rashmi D Patel Umang G Thakkar Aanal H Mehta Source Type: research

Knowledge and attitude toward organ donation among medical staff and outpatients at King Abdulaziz Medical City, Riyadh, Saudi Arabia
This study aims to assess the knowledge of Saudis about organ donation both among the public and the medical staff and to assess the trend in the change from 1996 until now. A cross-sectional study was conducted among Saudis above the age of 18 years. A self-administered, 25-item, questionnaire was completed by participants including both outpatients and medical staff at King Abdulaziz Medical City using a convenient sampling technique. A total of 376 individuals answered the questionnaire; 238 (63.1%) heard about SCOT, of whom 124 (70.5%) were males. Health-care professionals had better attitude and knowledge on organ donation (P
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Ibrahim Altraif Nourah Altuwaijri Lamia Aldhbiban Fai Alhoshan Raghad Alomari Afaf Moukaddem Hamad Alashgar Fajr Alqahtani Source Type: research

Awareness, knowledge, and perception of chronic kidney disease patients at renal medicine outpatients' clinic
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1351-1360. doi: 10.4103/1319-2442.308344.ABSTRACTChronic kidney disease (CKD) is a major cause of morbidity and mortality. Awareness and education of CKD patients positively influence its medical management and significantly diminish the economic burden on public health. We conducted a pretested, structured, questionnaire-based survey to assess the awareness, knowledge, and perception of CKD patients at Renal Medicine Outpatients' Clinic. The questionnaire was distributed to all CKD patients of at least one-year duration after their diagnosis. A total of 200 patients completed...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Fatma Al Rahbi Issa Al Salmi Source Type: research

Effect of branched chain amino acid supplementation on dialysis adequacy and nutritional parameters in hemodialysis patients
This study aims to detect the effect of branched-chain amino acid (BCAA) supplementation on Kt/V and other nutritional parameters such as serum albumin as well as body mass index. Forty-six patients from the HD Unit of Mostafa Mahmoud Hospital were included in this study. Daily intake of BCAA was continued for three months. At the start of the study, before the intervention, and at the end of the 3rd month, we measured serum albumin, valine, leucine, iso-leucine, and Kt/V. Analysis of data was performed using paired and independent t-test. We found that BCAA has a highly significant effect on increasing the level of albumi...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Sameh Abou Zeid Ahmed Rabiee Fatma A El Refaey Nevine Sherif Source Type: research

Prognostic value of the Oxford classification and the Oxford score in IgA nephropathy: A Tunisian study
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1366-1375. doi: 10.4103/1319-2442.308348.ABSTRACTImmunoglobulin A nephropathy is the most common primary glomerular disease. The main challenge in this disease is the evaluation of prognostic factors for end-stage renal disease. The aim of our study was to describe the characteristics of immunoglobulin A nephropathy, to evaluate the histological data according to Oxford classification, and to identify factors associated with renal survival. This was a retrospective study, including adults with primary immunoglobulin A nephropathy. The study was conducted over a period of 10 ye...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Hela Jebali Hiba Ghabi Ikram Mami Badr Ben Kaab Lilia Ben Fatma Wided Smaoui Slim Haouet Hend Ben Mahjouba Mohanad Hassan Fethi Ben Hmida Lamia Raies Mohamed Karim Zouaghi Source Type: research

Postdiarrheal hemolytic uremic syndrome in Egyptian children: An 11-year single-center experience
This study aims to reveal the characterization of D+ HUS in Egyptian children. This is a retrospective study of all children with D+HUS admitted to a tertiary pediatric hospital in Egypt between 2007 and 2017. The study included epidemiological, clinical and laboratory data; management details; and outcomes. A cohort of 132 children aged 4months to 12 years was analyzed. Yearly incidence peaked in 2017, and spring showed the highest peak. All cases had a diarrheal prodrome that was bloody in 83% of the cases. Edema and decreased urine output were the most frequent presentations (50.3% and 42.4%, respectively). Escherichia ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Riham Eid Ashraf Bakr Atef Elmougy Mohamed M Zedan Nahla A Allam Amr Sarhan Ayman Hammad Ahmed M El-Refaey Nashwa Hamdy Source Type: research

Attitude and levels of awareness toward organ donation and transplantation among healthcare providers: A cross-sectional study
In conclusion, the level of perception and knowledge about organ donation among health-care providers was inadequate, although they showed positive attitudes toward this issue.PMID:33565451 | DOI:10.4103/1319-2442.308351 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Hatan Mortada Nawal Mashni Alharbi Marya Abdullah Alsuhaibani Rawan Abdullah Buhlagah Yasmina Nezar Mohamed Amjad Alharbi Osama Y Safdar Source Type: research

Bilateral renal cortical necrosis in a child with acute pancreatitis
In this report, we describe a child with severe acute pancreatitis complicated by bilateral RCN.PMID:33565452 | DOI:10.4103/1319-2442.308353 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Vybhav Venkatesh Aradhana Aneja Aditi Kumar Raja Ramachandran Sadhna Bhasin Lal Source Type: research

Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
We report a 73-year-old male with no relevant past medical history who presented with nephrotic syndrome and jaundice. Subsequent studies revealed immunoglobulinM (IgM) monoclonal gammopathy. Kidney biopsy revealed monoclonal Ig deposition disease and amyloidosis. Bone marrow biopsy demonstrated
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Yao-Ko Wen Source Type: research

Anticoagulant-related nephropathy: A case report
We report a case of a 64-year old man with biopsy-proven ARN who presented with over anticoagulation and acute chronic kidney injury while on warfarin therapy for his left lower limb deep-vein thrombosis. Various investigations were performed and renal biopsy confirmed the diagnosis of anticoagulant-related nephropathy.PMID:33565454 | DOI:10.4103/1319-2442.308356 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Kee Tat Lee Wan Syahira Wan A Kammal Boon Huei Kong Source Type: research

Chyluria with massive proteinuria: Do not reach for the biopsy gun!
We report on a patient presenting with persistent chyluria due to filariasis, whose clinical course was complicated by massive proteinuria and severe hypoalbuminemia. Treatment with dietary manipulation, antifilarials, and sclerotherapy resulted in successful reversal of the above abnormalities. It has been reported that chyluria is not associated with massive proteinuria, or that even in cases of massive proteinuria, hypoalbuminemia is not seen and implies a glomerular pathology. We argue that chyluria is always associated with proteinuria, which may be massive, and does not warrant a kidney biopsy unless proteinuria pers...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Manoj K Sudrania Anna T Valson Anuj D Dangi Nitin S Kekre Source Type: research

Septicemic melioidosis complicating undiagnosed chronic kidney disease and beta-thalassemia minor in a Bangladeshi farmer
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1411-1414. doi: 10.4103/1319-2442.308358.ABSTRACTMelioidosis is an emerging infectious disease in many countries including Bangladesh. Patients with diabetes mellitus are at increased risk for infection by Burkholderia pseudomallei, the causative agent for melioidosis. Here, we report an autochthonous case of septicemic melioidosis occurring in a middle-aged non-diabetic Bangladeshi farmer who presented with prolonged pyrexia and splenomegaly. Diagnostic workup revealed splenic micro-abscesses, previously undetected chronic kidney disease (CKD) and beta-thalassemia minor. This...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Muhammad Abdur Rahim Muhammad Abu Yousuf Khan Tufayel Ahmed Chowdhury Mehruba Alam Ananna Source Type: research

The significance of anti-phospholipase receptor antibodies in a patient with membranous nephropathy
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1415-1419. doi: 10.4103/1319-2442.308360.ABSTRACTMembranous nephropathy (MN) is the major cause of nephrotic syndrome in adults and may be secondary to systemic lupus erythematosus or malignancy in 25% of patients. Without any etiology, it is called primary MN, which is usually associated with phospholipase A2 (PLA2) receptor antibodies. Secondary MN can appear months before a secondary cause is identified. Here, we report a case of MN, that was found to be secondary to pancreatic adenocarcinoma and positive for PLA2 receptor antibodies.PMID:33565457 | DOI:10.4103/1319-2442.30...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Jayaprakash R Dasari Pallavi Reddy Yeshwanter Radhakrishnan Nikhil Nair Ronith Chakraborty Lena Nemer Rupesh Raina Source Type: research

Rare renal pathologic manifestation of antineutrophil cytoplasmic antibodies associated vasculitis as suppurative interstitial nephritis: A case report and review of the literature
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1420-1426. doi: 10.4103/1319-2442.308362.ABSTRACTA 69-year old male patient attended our clinic with fatigue, fever, anuria, nephritic syndrome and severe renal failure. Kidney biopsy showed pauci-immune crescentic glomerulonephritis with an unusual association of suppurative interstitial nephritis. Though most patients with renal involvement linked to antineutrophil cytoplasmic antibodies associated vasculitis (AAV) have pauci-immune glomerulonephritis, only a few patients were identified to have atypical renal pathology. In most cases, mononuclear tubulointerstitial infiltra...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Sultan Ozkurt Mustafa Fuat Acikalin Cigdem Mengus NazifeSuleYasar Bilge Ahmet Ugur Yalcin Source Type: research

Meropenem at recommended dose is a potential risk for seizure in hemodialysis patient
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1427-1431. doi: 10.4103/1319-2442.308364.ABSTRACTDosage adjustment of meropenem is usually recommended in hemodialysis (HD) patients and about 30% of meropenem is cleared during regular HD sessions. However, most of the published trials excluded patients on regular HD. Little is known about the accurate dosage of meropenem needed to avoid central nervous system toxicity. Herein, we report a 65-year-old Saudi female, a known case of end-stage renal disease on regular HD, who was admitted because of pyelonephritis and started on meropenem in the recommended dose according to cul...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Abdullah Al-Hwiesh Amani Alhwiesh Ibrahiem Saeed Abdul-Rahman Ali Al-Harbi Dujanah Mousa Sami Skiker Abdulaser Abdulkhani Hesham Beheri Morwa Radi Dalal AlKhaldi Azeeza Aldwaihi Saad Alqahtani Source Type: research

Successful desensitization and kidney transplantation in the presence of donor-specific anti-human leukocyte antigen antibodies in kidney transplant recipients
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1432-1438. doi: 10.4103/1319-2442.308365.ABSTRACTKidney transplantation has indisputably revamped renal medicine and restored hope among patients coming across fatal end-stage renal disease. However, sensitization of human leukocyte antigen (HLA) triggers extensive immunological fences to successful kidney transplantation and henceforth, transplant candidates are frequently demoted to the ever-growing waiting list owing to preformed donor specific antibodies (DSAs). Over the past few years, the advent of desensitization protocols has significantly overpowered the immunological...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Muhammad Tassaduq Khan Rashid Bin Hamid Sabahat Sarfaraz Naranjan Lal Jaleel Ahmed Shobha Luxmi Source Type: research

Successful experience of coronavirus disease-2019 pneumonia in a renal-transplant recipient
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1439-1440. doi: 10.4103/1319-2442.308366.NO ABSTRACTPMID:33565461 | DOI:10.4103/1319-2442.308366 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Gioacchino Li Cavoli Antonio Amato Chiara Iaria Francesco Onorato Francesca Finazzo Rosalia Mongiovi Barbara Oliva Vitalba Azzolina Tancredi Vincenzo Li Cavoli Camillo Carollo Source Type: research

Comment on "Biopsy-proven renal pathologies: Experience from multan institute of kidney diseases"
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1441-1442. doi: 10.4103/1319-2442.308367.NO ABSTRACTPMID:33565462 | DOI:10.4103/1319-2442.308367 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Gioacchino Li Cavoli Calogera Tortorici Luisa Bono Angelo Ferrantelli Camillo Carollo Vitalba Azzolina Antonio Amato Rosalia Mongiov ì Barbara Oliva Carlo Giammarresi Carmela Zagarrigo Tancredi Vincenzo Li Cavoli Franca Servillo Onofrio Schillaci Angelo Source Type: research

Can transmembrane protease serine 2 be attributed to coronavirus disease-2019 related acute kidney injury predominance in males?
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1443-1444. doi: 10.4103/1319-2442.308368.NO ABSTRACTPMID:33565463 | DOI:10.4103/1319-2442.308368 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Lujain Mohammad Dkhil AlDkhil Abeer Ageel Alenazi Source Type: research

Favorable kidney recovery by extracorporeal light chain removal and anti-myeloma treatments in patients with newly diagnosed multiple myeloma and acute renal failure
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1445-1447. doi: 10.4103/1319-2442.308370.NO ABSTRACTPMID:33565464 | DOI:10.4103/1319-2442.308370 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Giorgio Silvestrini Paola Tatangelo Laura Scaramucci Germana Sfara Francesco Bondanini Pasquale Niscola Paolo de Fabritiis Roberto Palumbo Source Type: research

The specificity of the novel coronavirus infection in transplantation recipients
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1448-1450. doi: 10.4103/1319-2442.308371.NO ABSTRACTPMID:33565465 | DOI:10.4103/1319-2442.308371 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Driss Elkabbaj Abdelali Bahadi Source Type: research

Management of kidney transplant recipients with coronavirus disease 2019
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1451-1454. doi: 10.4103/1319-2442.308372.NO ABSTRACTPMID:33565466 | DOI:10.4103/1319-2442.308372 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Muhammad Tassaduq Khan Rashid Bin Hamid Naranjan Lal Source Type: research

Novel coronavirus infection (COVID-19) and renal failure: An observation from cases in the 1 < sup > st < /sup > month of outbreak
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1455. doi: 10.4103/0976-7428.308373.NO ABSTRACTPMID:33565467 | DOI:10.4103/0976-7428.308373 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Pathum Sookaromdee Viroj Wiwanitkit Source Type: research

Coronavirus disease 2019: Implications of severe acute respiratory syndrome coronavirus 2 in acute kidney injury
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1456-1457. doi: 10.4103/1319-2442.308374.NO ABSTRACTPMID:33565468 | DOI:10.4103/1319-2442.308374 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Abeer Ageel Alenazi Lujain Mohammad Dkhil AlDkhil Source Type: research

Renal replacement therapy in the Kingdom of Saudi Arabia
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1458-1469. doi: 10.4103/1319-2442.308375.NO ABSTRACTPMID:33565469 | DOI:10.4103/1319-2442.308375 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Besher Al Attar Source Type: research

Pregnancy-associated hemolytic uremic syndrome
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1180-1188. doi: 10.4103/1319-2442.308326.ABSTRACTPregnancy-associated hemolytic uremic syndrome (P-aHUS) is not an uncommon condition. It is considered a medical emergency that is associated with a high risk of mortality and serious morbidity. End-stage renal disease as a consequence of P-aHUS occurs in>50% of the patients if left untreated; the majority of identified cases (79%) are during the postpartum period. Its mechanism of action is related mainly to the disturbance in the activation of the complement alternative pathway, leading to damage of the microvascular endoth...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Sami Alobaidi Ammar AlDabbagh Amany Alamoudi Murad Almowarey Ahmed Akl Source Type: research

Genetic screening in children with challenging nephrotic syndrome
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1189-1197. doi: 10.4103/1319-2442.308327.ABSTRACTGenetic screening paradigms for the nephrotic syndrome (NS) in the developed world are well established; however, screening in developing countries has received only minor attention. We retrospectively analyzed a cohort of all children who underwent genetic testing for challenging NS from our registry in the 10-year interval from 2000 to 2010 and based on 58 patients aged 0-12 years with at least one of the following clinical diagnosis: Nonsyndromic steroid-resistant nephrotic syndrome (SRNS), familial NS, and congenital NS. Of ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Bassam Saeed Source Type: research

Urinary podocalyxin: Is it a real index of disease activity in egyptian patients lupus nephritis?
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1198-1205. doi: 10.4103/1319-2442.308328.ABSTRACTSystemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by production of a number of antinuclear antibodies. Podocyte injury is an important feature and can be detected by several markers including podocalyxin. We aimed to evaluate the impact of SLE on urinary levels of podocalyxin and to determine its relationship to renal biopsy, proteinuria, and disease activity in lupus nephritis (LN) patients. Sixty individuals were recruited; 30 SLE patients with LN as well as 30 healthy volunteers and they w...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Ahmed Fayed Mahmoud M Elnokeety Mohamed Elyamny Hany Hammad Dina Hesham Ahmed Soliman Reham Abdelghany Ahmed Source Type: research

Interleukin 18 as a new inflammatory mediator in left ventricular hypertrophy in children with end-stage renal disease
This study shows that elevated hsCRP and IL-18 are independent determinants of LVH in HD children. Understanding the role of inflammatory molecules in the pathogenesis of LVH in ESRD is important for prediction of high-risk group and implementation of targeted anti-inflammatory therapies.PMID:33565432 | DOI:10.4103/1319-2442.308329 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Ahlam Badawy Dalia A Nigm Ghada M Ezzat Yasser Gamal Source Type: research

Causes of the delay in creating permanent vascular access in hemodialysis patients
This study aims to identify the physicians' perspectives regarding the reasons of delayed arteriovenous fistula (AVF) creation in the Kingdom of Saudi Arabia to improve the quality of CKD patients' care and prognosis and prevent complications. A cross-sectional descriptive study was conducted on KSA nephrologists using a questionnaire which includes factors associated with delay in AVF creation, which were categorized into patient, physician, and hospital factors. The optimal timing of starting dialysis was also assessed. In a total of 212 participants, 131 (61.8%) were of consultant level, with the largest numbers being f...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Maha A Alfarhan Shahad A Almatrafi Sumaia M Alqaseer Yara A Albkiry Abdulla AlSayyari Source Type: research

A study of quality of life among hemodialysis patients and its associated factors using kidney disease quality of life instrument-SF36 in Riyadh, Saudi Arabia
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1225-1233. doi: 10.4103/1319-2442.308331.ABSTRACTWe aimed in this study to assess the quality of life for kidney-ill patients using Kidney Disease Quality of Life Instrument-SF36 (KDQOL-SF36) and the impact of other demographic, clinical, and social factors on patients' QOL. The quality of life was assessed using an Arabic version of KDQOL-36. The KDQOL-36 subscales Physical Component Summary (PCS), Mental Component Summary (MCS), Burden of Kidney Disease, and Effects of Kidney Disease were calculated. The effect of sex, diabetic status, diabetes mellitus, marital and status e...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Abdulaziz Ajeebi Abdulkarim Saeed Alwaleed Aljamaan Mujahid Alshehri Majed Nasradeen Nouf Alharbi Aamir Omair Abdulla A Al-Sayyari Source Type: research

Echocardiographic findings in children with chronic kidney disease
This study aims to determine the incidence of CVD in children with CKD, to analyze risk factors and early predictors for late onset atherosclerosis. Thirty-five CKD children [25 on regular hemodialysis (HD) and 10 on conservative management] were evaluated clinically. Left ventricular (LV) functions and carotid artery intima-media thickness (c-IMT) were assessed using conventional echocardiography, pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI). There was decreased E/A ratio and increased E/E' ratio in 66% and 77% of patients, respectively signifying diastolic cardiac dysfunction. There was a significant correl...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Bahia Moustafa Hanan Zekry Rania Hamdi Hashim Doaa Mohamed Salah Ahmed Abdelwahed Abdelfattah Rodina Sobhy Source Type: research

Evaluation of visual evoked potentials and brain-stem auditory evoked response in patients of chronic kidney disease
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1245-1253. doi: 10.4103/1319-2442.308333.ABSTRACTChronic kidney disease (CKD) is associated with functional changes in the central nervous system (CNS) which, in the initial stages do not manifest clinically. Early involvement of the CNS can be identified by the assessment of the electrocortical activity. Visual evoked potential (VEP) and brain-stem auditory evoked response (BAER) are useful tests for the early diagnosis of CNS involvement in CKD and are more sensitive compared to electroencephalography. One hundred adult CKD patients (stage 3-5 and 5D) and 50 controls were in...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: H K Aggarwal Deepak Jain Shailesh Bhatia Source Type: research

Significance of ambulatory blood pressure monitoring in assessment of potential living kidney donors
In conclusion, ABPM is a reliable modality for the identification of masked HTN and white coat HTN. Masked HTN is correlated with increased risk of end organ damage and risk of death in potential kidney donors. Transplant physicians cannot rely solely on office BP monitoring in the assessment of potential living kidney donors. ABPM should be integral part of routine assessment of potential living kidney donors.PMID:33565437 | DOI:10.4103/1319-2442.308334 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 10, 2021 Category: Urology & Nephrology Authors: Niamh M Brady Hatem Ali Fiona Biggins Aimun Ahmed Source Type: research