Spectrum of glomerular diseases in Arab countries: A systematic review.
In conclusion, FSGS and LN are the most common types of primary and secondary glomerular diseases, respectively, in all evaluated Arab countries. The trend of all types of glomerular diseases has not changed in the last three decades. We strongly recommend that each Arab country should have its own renal biopsy registry. PMID: 30588955 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Alwahaibi NY, Al Issaei HK, Al Dhahli BS Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparative analysis for optimizing the modified release tacrolimus (Advagraf) after kidney transplantation: A prospective randomized trial.
Abstract Immunosuppression management in clinical transplantation aims to balance delivery of efficacy against adverse reactions using therapeutic drug monitoring. Adherence to posttransplant immunosuppressive medications and minimizing variability in drug exposure are important considerations in preventing rejection and maximizing overall transplant outcomes. The availability of once-daily tacrolimus may add a potential benefit by simplifying immunosuppressive regimens, though improving compliance among transplant recipients. The aim of our study is to investigate the safety and efficacy of the once-daily formula...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Bakr MA, Nagib AM, Donia AF, Denewar AA, Abu-Elmagd MM, Abbas MH, Abdel-Rahman AM, Mashaly ME, Elsaftawy MM, Ghoneim MA Tags: Saudi J Kidney Dis Transpl Source Type: research

Effect of thyroid function status in hemodialysis patients on erythropoietin resistance and interdialytic weight gain.
Abstract Thyroid function abnormalities are common in hemodialysis (HD) patients. Here, we investigated their frequency and impact on intradialytic hemodynamics and erythropoietin resistance index (ERI). Demographic and laboratory data including thyroid-stimulating hormone (TSH), interdialytic weight gain, and intradialytic blood pressure (BP) changes were measured, and ERI was calculated. The prevalence and causes of abnormities in TSH and free thyroxine (FT4) and their effects on ERI and intradialytic hemodynamics were then assessed. One hundred and thirty patients (mean age, 57.1 ± 19.2 years; 66.4% diab...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Bin Saleh FS, Naji MN, Eltayeb AA, Hejaili FF, Al Sayyari AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of left ventricular mass changes after arteriovenous fistula surgical banding in end-stage renal disease.
In this study, we describe a cohort of asymptomatic patients with LVH who underwent AVF banding with a two-dimensional-echocardiogram done before and after the intervention to evaluate the association between AVF surgical banding and left ventricular mass (LVM) changes. Our results show that AVF surgical banding did not alter the left ventricular mass index (LVMI) with a mean prebanding LVMI of 70.3 ± 57.5 g/m2 and mean postbanding LVMI of 81.9 ± 55.9 g/m2, (P = 0.4). Our study shows that AVF flow reduction by surgical banding did not alter LVMI, and therefore LVH, in end-stage renal disease patients who have...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Cortesi C, Duque JC, Mai S, Martinez L, Dejman A, Vazquez-Padron R, Salman L, Tabbara M Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinical and laboratory findings of patients with diabetes undergoing kidney biopsy.
This study represents the findings of the whole country for more than 10 years. It showed that only a small percentage of patients with DM undergo kidney biopsy. These patients have many clinical and laboratory abnormalities including those of specific immuno-logical investigations. Progression of DM nephropathy seems to be further aggravated by many coexisting risk factors of dyslipidemia and/or obesity. The prevalence of non-DKD is remarkably frequent in diabetics in whom nephrologists should consider kidney biopsy as an appropriate measure to enable better management. PMID: 30588959 [PubMed - in process] (Source: S...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Mohammed E, Atris A, Al Salmi I, Al-Menawi L, Shaheen F, Hannawi S Tags: Saudi J Kidney Dis Transpl Source Type: research

A single-center 4-year experience with 47 pediatric renal transplants: Evolving trends.
Abstract Outcome of pediatric kidney transplantation (KT) has improved over the last several decades. We retrospectively reviewed the outcomes pediatric KT in King Faisal Specialist Hospital and Research Center-Jeddah, Saudi Arabia. Between May 2013 and November 2016, we performed renal transplantation in 47 children, 30 (64%) males, and 17 (36%) females. All patients received antibody induction with basiliximab or antithymocyte globulin along with triple immunosuppressive therapy with tacrolimus, mycophenolate mofetil and steroids. Twenty-four (51%) and 14 (30%) patients were on hemodialysis and peritoneal dialys...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: El Hennawy HM, Al Hashemy A, Al Harbi N, Habhab WT, Fahmy AE Tags: Saudi J Kidney Dis Transpl Source Type: research

Impact of Enterobacteriaceae bacteremia on survival in patients with hepatorenal failure.
Abstract Enterobacteriaceae are now the predominant pathogens isolated in patients with liver cell failure associated with bloodstream infections. We conducted a retrospective cohort study of patients who were admitted for the diagnosis of hepatorenal failure (HRF) between June 1999 and May 2008 to investigate the risk factors of Enterobacteriaceae bacteremia (EB). EB was defined as the isolation of an EB species from at least one blood culture within three months following diagnosis of HRF. Variables were collected from the medical records and analyzed in relation to EB. Twenty-four (32.5%) of the 73 patients dev...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Soliman AR, Ahmed RM, Abdalla A, Soliman M, Saeed M Tags: Saudi J Kidney Dis Transpl Source Type: research

Posttransplant diabetes mellitus among live-related kidney transplant recipients: Sindh Institute of Urology and Transplantation experience.
Abstract This cross-sectional study conducted at Sindh Institute of Urology and Transplantation, Karachi, Pakistan aimed to determine the frequency and risk factors of posttransplant diabetes mellitus (PTDM) among live-related kidney transplant recipients and their short-term prognosis and included renal transplant recipients (nondiabetic before transplant) of either gender, aged 18-60 years with transplant duration two to six months. Patients with two reading of fasting plasma glucose ≥126 mg/dL were labeled as diabetic. A total of 191 patients (154 males and 37 females) with the age between 18 to 60 years (31...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Mohammad KG, Idrees MK, Ali T, Akhtar F Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of knowledge and attitude toward organ donation among the Saudi population in Riyadh City.
Abstract We aimed to assess the knowledge and attitude of the Saudi population and students of health science colleges as well as healthcare workers in Riyadh city about organ donation (OD). Data of this study were collected from 648 Saudi residents of Riyadh city using interviewer-administered questionnaires and online surveys. The participants included 503 from the general population and 145 health science professionals. The subjects included 252 males and 396 females with mean age of 27.09 ± 9 years. Majority of the participants (60%) were aware of OD from media as the main source of information, while o...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Alsharidah DS, Al-Dossari FS, AlMahmoud N, Alanzan BA, Binkhulaif RJ, Bakhsh EM, Alkhalaf AA, Bin Huzim BA, Sarhan NT, Sulayem LM, ElFeky DS, Syed S Tags: Saudi J Kidney Dis Transpl Source Type: research

Impact of correction of anemia in end-stage renal disease patients on cerebral circulation and cognitive functions.
Abstract End-stage renal disease (ESRD) patients have been associated with accelerated vascular disease of the cerebral circulation due to uremic toxins. Furthermore, anemia increases cerebral oxygen extraction fraction which impairs the cerebral vasodilatory capacity. We evaluated the effect of correction of anemia on cerebral blood flow by measuring the mean blood flow velocity, resistance index (RI), and pulsatility index (PI) in the middle cerebral artery (MCA) in relation to cognitive functions. We measured the mean blood flow velocity, RI, and PI in MCA of 120 ESRD patients when the hemoglobin (Hb) ranges be...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Shaker AM, Mohamed OM, Mohamed MF, El-Khashaba SO Tags: Saudi J Kidney Dis Transpl Source Type: research

Effectiveness of prehemodialysis preparatory program on improving coping among chronic kidney disease patients.
Abstract Diagnosis of chronic kidney disease (CKD) and initiation of dialysis treatment is reported to be stressful for patients. It is essential that patients use effective coping strategies to deal with these stressors, since ineffective coping could have several adverse effects on various treatment-related as well as personal aspects of life, thereby lowering the quality of life in these patients. The study used a quasi-experimental design. The study population comprised 100 adult patients with Stage 3 and Stage 4 CKD whose glomerular filtration rate was deteriorating and required to undergo hemodialysis (HD) t...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Jadhav ST, Lee P, D'souza CV Tags: Saudi J Kidney Dis Transpl Source Type: research

Arteriovenous fistula outcomes in human immunodeficiency virus-positive patients.
Abstract Arteriovenous fistula (AVF) remodeling is an active area of research in vascular biology given the high rates of primary failure, complications, and cost burden for the health-care system. Comorbidities such as diabetes and different types of vascular disease are known to influence AVFs outcomes. However, little is known about the effects of immunosuppression, particularly human immunodeficiency virus (HIV) infection, on AVF primary failure and patency. This retrospective study assessed the impact of HIV infection and T-cell counts on AVF outcomes. Using a retrospective cohort of 495 patients, we compared...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Duque JC, Martinez L, Tabbara M, Salman LH, Vazquez-Padron RI, Dejman A Tags: Saudi J Kidney Dis Transpl Source Type: research

Knowledge, attitudes, and practice of organ donation in Morocco: A cross-sectional survey.
Abstract In any health system, public awareness of organ donation fundamentally affects the organ transplantation programs. The aim of this study was to evaluate the knowledge and perception of the people in Morocco toward organ donation as well as to identify the reasons and determinants for refusal of organ donation. This opinion survey included a representative sample of 2000 participants in Morocco, and data related to sociodemographic characteristics, knowledge and self-opinion about organ donation, and reasons behind refusal were collected. Statistical analysis showed that 55.2% of the participants were wome...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: El Hangouche AJ, Alaika O, Rkain H, Najdi A, Errguig L, Doghmi N, Aboudrar S, Cherti M, Dakka T Tags: Saudi J Kidney Dis Transpl Source Type: research

BK Virus nephropathy in living donor renal allograft recipients: An observational study from a large transplant center in India.
Abstract BK virus is a polyoma virus which remains in latent phase in the urinary tract, particularly in the renal tubular epithelial cells. In immunosuppressed patients, it is activated and manifests as tubule-interstitial nephritis causing renal allograft dysfunction. A total of 402 patients who underwent renal allograft biopsy from 2013 to 2016 were included in this study; six patients were diagnosed to have BK virus nephropathy. Histopathology showed ground glass intra-nuclear inclusions accompanied by acute tubular injury, interstitial inflammation, and varying degree of interstitial fibrosis and tubular atro...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Gupta P, Gupta A, Bhalla AK, Malik M, Gupta A, Bhargava V, Rana DS Tags: Saudi J Kidney Dis Transpl Source Type: research

G6PD deficiency is not an uncommon cause of pigment nephropathy.
Abstract Acute kidney injury (AKI) with evidence of hemolysis is associated with tropical infections. However, pigment-induced AKI can happen with relatively uncommon genetic causes of hemolytic anemia, i.e., glucose 6-phosphate deficiency (G6PD). We share our experience of three such patients whose clinical presentation was similar to jaundice, AKI with hemolysis with suspicion of thrombotic microangiopathy. On evaluation, all had a history of usage of anti-malarial and with G6PD estimation revealing deficient status even during the episode while other tests such as Coomb's test and bone marrow biopsy was normal ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Kaul A, Prasad P, Kumari N, Bhaduaria D, Sharma RK, Prasad N, Gupta A, Krishnani N Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison of tacrolimus and cyclosporine for immunosuppression after renal transplantation: An updated systematic review and meta-analysis.
Abstract Kidney transplantation is usually followed by immunosuppressive therapy to prevent early rejection and prolong graft survival. The calcineurin inhibitors (CNIs) represent the most commonly used agents. However, available evidence suggests the poor outcome over the long term, maybe be due to the potential nephrotoxicity associated with CNIs. Several randomized trials have compared tacrolimus (TAC) with cyclosporine, to find the optimal agent for renal transplantation; however, studies have shown conflicting results. The aim of this study was to systematically review and update the evidence for the benefits...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Azarfar A, Ravanshad Y, Mehrad-Majd H, Esmaeeli M, Aval SB, Emadzadeh M, Salehi M, Moradi A, Golsorkhi M, Khazaei MR Tags: Saudi J Kidney Dis Transpl Source Type: research

Mortality of diabetic on chronic dialysis in Tunisia.
This study aims to specify the epidemio-logical, clinical, and biological characteristics of diabetic disease, chronic kidney disease (CKD), and comorbidities at the initiation of HD and investigate factors associated with mortality during the dialysis period. We retrospectively analyzed the outcome of diabetic patients who were initiated on HD from 2007 to 2012 at the Rabta Hospital of Tunis. During the follow-up period, all morbid events and deaths were recorded. Univariate analysis and multivariate analysis were performed to identify risk factors associated with mortality in our population. The study population included...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Jebali H, Laifi M, Mami I, Khadhar M, Chirmiti M, Beji S, Rheder R, Smaoui W, Krid M, Hmida FB, Rais L, Fatma LB, Zouaghi MK Tags: Saudi J Kidney Dis Transpl Source Type: research

Urinary schistosomiasis in Boko Haram-related internally displaced Nigerian children.
Abstract We aimed to determine the prevalence of urinary schistosomiasis among internally displaced children in Maiduguri, Nigeria. Data on the children's sociodemographic characteristics and risk factors for schistosomiasis were collected, over a period of six months, using an interview-based questionnaire. Ten milliliter of urine sample was collected from each child and investigated for hematuria and ova of Schistosoma haematobium. Two hundred and thirty-eight of 385 children had urinary schistosomiasis (62.0%); of this, 125 (53.0%) were males, with a male:female ratio of 1.1:1. Urinary schistosomiasis was the m...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Yauba SM, Rabasa AI, Farouk AG, Elechi HA, Ummate I, Ibrahim BA, Ibrahim HA, Baba AS, Boda TA, Olowu WA Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.
Abstract Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. RB was performed under Ketamine-Midazolam sedation and real-time ultrasound. Trucut or monopty biopsy gun was used. Data obtained included age, gender, clini...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Sadaf A, Khemchand MN, Fouzia L, Asia Z Tags: Saudi J Kidney Dis Transpl Source Type: research

Pattern of glomerular disease and clinicopathological correlation: A single-center study from Eastern Nepal.
Abstract The pattern of glomerular disease varies worldwide. In the absence of kidney disease/kidney biopsy registry in Nepal, the exact etiology of different forms of glomerular disease is primarily unknown in our country. We analyzed 175 cases of renal biopsies performed from September 2014 to August 2016 in Internal Medicine Ward at B.P. Koirala Institute of Health Sciences. The most common indication for renal biopsy was nephrotic syndrome (34.9%), followed by systemic lupus erythematosus (SLE) with suspected renal involvement (22.3%). Majority of patients were in the 30-60 years' bracket (57.2%), with the mea...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Subedi M, Bartaula B, Pant AR, Adhikari P, Sharma SK Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of knowledge of chronic kidney disease among non-nephrology nurses in Akure, South-West Nigeria.
This study assessed the knowledge of non-nephrology nurses on CKD with the aim of identifying areas of knowledge gaps which will be targets for future educational programs. This was a cross-sectional descriptive study carried out among nurses in Akure, Southwest Nigeria during their mandatory continuing professional development program required for practicing license renewal. Knowledge of CKD was assessed using self-administered pretested questionnaires. P
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Adejumo OA, Akinbodewa AA, Iyawe IO, Emmanuel A, Ogungbemi O Tags: Saudi J Kidney Dis Transpl Source Type: research

Quality of hemodialysis services in a poor population, Sistan and Baluchestan province, Iran: A descriptive, prospective study.
This study aimed at investigating quality-of-care indicators among hemodialysis (HD) patients. This descriptive, prospective study was conducted on 144 HD patients in Zabol and Iranshahr dialysis centers from March 21 to December 22, 2015. Measurement indicators included hemoglobin level, dialysis adequacy, albumin level, vascular access, and calcium and phosphorus levels. The mean hemoglobin and dialysis adequacy level at baseline were 10.58 ± 1.6 g/dL and 1.09 ± 0.18, respectively. At the end of the study, 49.6% of participants achieved target hemoglobin level. However, only 18.6% of patients achieved targe...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Balouchi A, Shahdadi H, Shahkzhi A, Irandgani M, Aboo S, Bolaydehyi E, Hooti M, Lundquist CM, Shahraz S Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of iron status in predialysis chronic kidney disease patients in a Nigerian Tertiary Hospital.
This study assessed iron status and associated factors in predialysis CKD patients in Southern Nigeria. This was a cross-sectional study that assessed and compared iron status in 100 predialysis CKD patients and 90 healthy controls. Mean age of the CKD patients was 49.39 ± 14.84 years. Iron deficiency was present in 14% of CKD patients compared to 3% of the controls (P = 0.021). Among CKD patients with ID, 11 (85.7%) had functional iron deficiency while three (14.3%) had absolute iron deficiency. Serum ferritin was significantly higher in the predialysis CKD patients (P = 0.001). There was no significant gender diff...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Iyawe IO, Adejumo OA, Iyawe LI, Oviasu EO Tags: Saudi J Kidney Dis Transpl Source Type: research

A review of the epidemiology of chronic kidney disease in Pakistan: A global and regional perspective.
Abstract Both the incidence and prevalence of chronic kidney disease (CKD) are rising with immense pace worldwide. People living in developing countries are speculated to suffer the consequences due to economic deprivation and high cost of treatment. The prevalence of CKD is highly variable in different parts of the world, due to various environmental, ethnic, socioeconomical, and rural-urban differences. It has become very important for the developing countries to understand the true nature of the disease and its prevalence, rather than to hypothesize or make supposition on the bases of Western data. It is impera...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Imtiaz S, Salman B, Qureshi R, Drohlia MF, Ahmad A Tags: Saudi J Kidney Dis Transpl Source Type: research

The National Guard Health Affairs guidelines for the medical management of renal transplant patients.
Abstract PMID: 30588979 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Arabi Z, Theaby A, Farooqui M, Abdalla M, Hajeer A, Abdullah K Tags: Saudi J Kidney Dis Transpl Source Type: research

Safe correction of severe hyponatremia in patient with severe renal failure using continuous venovenous hemofiltration with modified sodium content in the replacement fluid.
We described a safe correction of severe hyponatremia in a 42-year-old male patient requiring dialysis, who was treated with continuous venovenous hemofiltration using hypotonic replacement fluid which was prepared and adjusted on a daily basis. PMID: 30588980 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Alqurashi BY, Gramish JA Tags: Saudi J Kidney Dis Transpl Source Type: research

Mammalian target of rapamycin inhibitors in a patient with polycystic kidney disease-1-tuberous sclerosis-2 contiguous gene syndrome.
We present a case report of a young girl who presented with skin lesions, central nervous system tubers, and cystic disease of the kidneys. She was treated with mammalian target of rapamycin inhibitors with a favorable outcome. PMID: 30588981 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Anandh U, Chandrasekar G, Agarwal V Tags: Saudi J Kidney Dis Transpl Source Type: research

Vitamin B1 for type B metabolic acidosis: An underrecognized approach.
We present a multifactorial case of lactic acidosis due to thiamine deficiency, liver disease, and lymphoma; all underrecognized causes of Type B lactic acidosis. PMID: 30588982 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Dejman A, Riveros J Tags: Saudi J Kidney Dis Transpl Source Type: research

Encapsulating peritoneal sclerosis associated with Burkholderia pseudomallei peritonitis.
We report a rare case of an end-stage renal disease patient on regular continuous ambulatory peritoneal dialysis (PD) who developed melioidosis PD peritonitis. Within a short period of time, she developed encapsulating peritoneal sclerosis evidenced by the intraoperative findings of intraabdominal cocooning. Choice and duration of antibiotic are important for proper eradication of the organism. Early diagnosis and treatment of both conditions also may improve the prognoses. PMID: 30588983 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Aulia Z, Wan Ali WASR, Shahar MA Tags: Saudi J Kidney Dis Transpl Source Type: research

Cerebral venous sinus thrombosis as a warning signal for double positive crescentic glomerulonephritis in a young male with complete renal recovery.
We present a young male who presented with CVT followed by rapidly progressive crescentic glomerulonephritis and with appropriate therapeutic modalities he had complete renal and partial neurological recovery. PMID: 30588984 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Jha VK, Padmaprakash KV, Pandey R, Sharda V, Sharma A Tags: Saudi J Kidney Dis Transpl Source Type: research

Relapsing Serratia peritonitis resulting in peritoneal catheter loss.
We present a case of a 40-year-old woman with end-stage renal disease secondary to chronic glomerulo-nephritis on continuous ambulatory peritoneal dialysis (PD). She presented with severe abdominal pain and a cloudy peritoneal fluid. The fluid was cultured according to our unit protocol. The organism isolated was identified as SM; this was after the patient was treated for SM peritonitis one week earlier. The response to treatment with ceftazidime was poor despite being sensitive in vitro. The peritoneal catheter was removed due to rapid clinical deterioration. Piperacillin-tazobactam (PIP/TAZ) monotherapy was successfully...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Kilic I, Gungor K, Kurultak I, Ustundag S Tags: Saudi J Kidney Dis Transpl Source Type: research

Bile cast nephropathy causing acute kidney injury in a patient with nonfulminant acute hepatitis A.
Abstract Hepatitis A is usually a benign self-limiting disease with few or no extrahepatic manifestations. Acute hepatitis A causing severe renal dysfunction is not very common, although described. Patients developing renal dysfunction post hepatitis A infection usually have prerenal acute kidney injury (AKI) or acute tubular necrosis due to vomiting, diarrhea, and poor fluid replacement. However, if renal dysfunction persists, other causes need to be evaluated. The term cholemic nephrosis or more specifically bile cast nephropathy has been described in the setting of cholestatic jaundice and decompensated liver f...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Ravi R, Suthar K, Murlidharan P, Lakshmi K, Balan S, Safeer M Tags: Saudi J Kidney Dis Transpl Source Type: research

Monoclonal B-cell lymphocytosis with renal involvement.
We report the case of a 70-year-old man with no relevant past medical history who presented with acute kidney injury. Kidney biopsy showed diffuse interstitial infiltration with typical chronic lymphocytic leukemia (CLL) phenotype B-cells. Subsequent studies revealed a normal lymphocyte count in the peripheral blood, and there was no evidence of lymphadenopathy or hepatosplenomegaly. Blood flow cytometry demonstrated a clonal B-cell population with a CLL phenotype. Without renal involvement, this case should be classified as monoclonal B-cell lymphocytosis. Renal function improved with steroid therapy. However, the patient...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Wen YK Tags: Saudi J Kidney Dis Transpl Source Type: research

Periarticular calcification mimicking inflammatory polyarthritis in chronic kidney disease.
Abstract Periarticular calcification is a frequent radiographic manifestation in chronic kidney disease (CKD). However, clinical presentation as inflammatory periarthritis, tenosynovitis, and bursitis is unusual. A 34-year-old man with CKD on dialysis for three years presented with painful swollen joints. His adherence to regular dialysis, phosphate binders, Vitamin D supplements, and antihypertension therapy was poor. He had swelling of the right thumb, index, and little fingers; periarticular swelling of the left middle finger and right little toe; and extensor tenosynovitis of the wrists and right olecranon bur...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Naidoo K, Ndlovu KCZ, Mody GM Tags: Saudi J Kidney Dis Transpl Source Type: research

Short-course metronidazole-induced reversible acute neurotoxicity in a renal transplant recipient.
We present a case of acute neurotoxicity due to short course of injectable metronidazole given in usual doses to a renal allograft recipient for persistent diarrhea. It responded to withdrawal of the offending drug. Tacrolimus trough concentration did not increase during neurotoxicity, thereby ruling out any metronidazole-tacrolimus interaction. Magnetic resonance imaging of the brain showed widespread osmotic demyelination and its recovery after drug withdrawal. This is the first reported case of a renal transplant recipient developing acute neurotoxicity due to short-term use of metronidazole, without any increase in tac...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Dogra PM, Bhatt AK, Agarwal SK, Bhowmik D Tags: Saudi J Kidney Dis Transpl Source Type: research

Ig M nephropathy - A clinicopathological study - Our experience.
Abstract PMID: 30588990 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Devi BV, Lakshmi BS, Padmavathi Devi SV, Ram R, Kumar VS Tags: Saudi J Kidney Dis Transpl Source Type: research

Magnitude of renal problem in fatal cases of Lassa fever: A summary on existed reports.
Abstract PMID: 30588991 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Yasri S, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Norovirus-associated hemolytic uremic syndrome in a renal transplant recipient.
Abstract PMID: 30588992 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2018 Category: Urology & Nephrology Authors: Gaur L, Gupta A, Shingada A, Bhalla AK, Gupta A, Malik M, Bhargava V, Rana DS Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of glycemic status during the days of hemodialysis using dialysis solutions with and without glucose.
Abstract Hypoglycemia has been documented during regular hemodialysis (HD) in both diabetic and nondiabetic end-stage renal disease (ESRD) patients. The aim of this study was to evaluate the glycemic fluctuations in diabetic and nondiabetic ESRD patients during HD days using glucose-free and glucose-containing dialysate. We conducted a prospective interventional study in which 32 ESRD patients (16 diabetic and 16 nondiabetic) were included in the study. All the patients underwent two HD sessions with glucose-free bicarbonate solution (phase 1) and next two HD sessions done with 100 mg/dL glucose-containing dialysa...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Padmanabhan A, Velayudham B, Vijaykumar N, Allauddin S Tags: Saudi J Kidney Dis Transpl Source Type: research

Scores of awareness and altruism in organ transplantation among Saudi health colleges students-impact of gender, year of study, and field of specialization.
This study aimed to evaluate the awareness of organ transplantation and willingness to donate among Saudi Health Colleges students and the impact of gender, year of study, and field of specialization on this. This is a cross-sectional survey-based study. The survey was distributed to all the students attending the annual national conference of Saudi Health Colleges students held in 2018. The survey had two parts. The first part collected the information about gender, university, college of specialization, and year of study. The second part asked 10 questions, seven of which were about the types, causes, treatment of organ ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: AlHejaili W, Almalik F, Albrahim L, Alkhaldi F, AlHejaili A, Al Sayyari A Tags: Saudi J Kidney Dis Transpl Source Type: research

Serum ferritin < 70 μg/L predicts functional iron deficiency in patients with chronic kidney disease.
Serum ferritin 18 years with hemoglobin
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Garg N, Kotru M, Yadav A, Rusia U, Sikka M, Kalra OP Tags: Saudi J Kidney Dis Transpl Source Type: research

Interleukin-6 gene polymorphisms and serum erythropoietin and hemoglobin in hemodialysis Iraqi patients.
This study aimed to evaluate the frequencies of 174G/C IL-6 gene promoter polymorphism in Iraqi hemodialysis (HD) patient and to examine the association between the allelic variations and serum erythropoietin (EPO) and hemoglobin (Hb) levels. The frequencies of IL-6 gene polymorphism were studied in 70 chronic renal failure patients on maintenance HD (patients group) and in 20 healthy participants (control group). Genotyping of IL-6 gene was performed by conventional polymerase chain reaction-restriction fragment length polymorphism. The distribution of IL-6 genotypes between groups was similar, and GG genotype is the most...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Al-Radeef MY, Allawi AAD, Fawzi HA Tags: Saudi J Kidney Dis Transpl Source Type: research

Study of therapeutic efficacy of febuxostat in chronic kidney disease stage IIIA to stage VD.
Abstract Hyperuricemia [serum uric acid (SUA)>7.0 mg/dL] which is common in chronic renal diseases is associated with augmented vascular events. In addition to nonpharmacological therapy, hypouricosuric drugs reduce UA levels. The current study was a prospective observational study of six months duration November 2016 to April 2017 done to determine the efficacy of febuxostat in patients with hyperuricemia in chronic kidney disease (CKD) stage G3a to G5 and to correlate any association with reduction of hypertension, improvement in glomerular filtration rate (GFR), and reduction in comorbidities. The study was ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Sarvepalli PS, Fatima M, Quadri AK, Taher AR, Habeeb A, Amreen F, Parveen BN, Rajaram KG Tags: Saudi J Kidney Dis Transpl Source Type: research

Plantago major protects against cisplatin-induced renal dysfunction and tissue damage in rats.
This study revealed that P. major extract in a dose-dependent manner provides protection against renal damage induced by cisplatin. PMID: 30381501 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Parhizgar S, Hosseinian S, Soukhtanloo M, Bideskan AE, Hadjzadeh MA, Shahraki S, Noshahr ZS, Heravi NE, Haghshenas M, Rad AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinical and laboratory profile of renal amyloidosis: A single-center experience.
Abstract The kidney is the most common organ involved in systemic amyloidosis. We aimed to study etiology and clinicopathological profile of renal amyloidosis. This was a retrospective study of 40 consecutive adult patients with biopsy-proven renal amyloidosis evaluated over a period of two years. Emphasis was given to describing the clinical presentation, renal function, proteinuria, type of amyloidosis, and its etiology. Mean age of the study cohort was 44 ± 15 years (with a male-to-female ratio of 3:1). Amyloid A (AA) amyloidosis was the most common type of amyloidosis observed in 72.5% of cases. Amyloid...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Engineer DP, Kute VB, Patel HV, Shah PR Tags: Saudi J Kidney Dis Transpl Source Type: research

Elimination of BK viremia in renal transplant recipients by optimization of immunosuppressive medications without precipitating acute rejection.
Abstract BK Polyomavirus-associated nephropathy (BKVAN) has been recognized as an increasing threat in renal transplant patients (RTP) for more than a decade. Reduction in immunosuppression is the mainstay of treatment through various options of treatment has been suggested. Published reports on these protocols have shown mixed results, and no randomized controlled trials have compared one strategy with another. In this context, we hypothesize that the appearance of BKV in the blood compels one to optimize the immunosuppression with possible long-term beneficial effects. We conducted a retrospective study among th...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Jha A, Ahmed W, Pakkyara A, Shaheen F, Al Salmi I Tags: Saudi J Kidney Dis Transpl Source Type: research

Red cell distribution width reflects the early stage residual renal function in peritoneal dialysis patients.
This study aimed to investigate the association of RDW with the residual renal function in peritoneal dialysis (PD) patients. The patients were categorized into three groups according to the quartiles of their baseline RDWs. The correlations between RDW and clinical parameters, dialysis adequacy, and residual renal function were analyzed. The clinical data, PD prescription and dialysis adequacy of 54 uremic patients on continuous ambulatory PD were collected. All the statistical analyses were performed using the Statistical Package for the Social Sciences program version 17.0. The baseline RDW of the patients was 13.56% &p...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Zhang Q, Cao X, Zhou J, Ding R, Huang J, Cai G, Chen X Tags: Saudi J Kidney Dis Transpl Source Type: research

The long-term impact of hepatitis C infection in kidney transplantation in the pre-direct acting antiviral era.
This study can serve as a benchmark for future studies to compare the long-term effect of Direct Acting Antiviral drugs. PMID: 30381505 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Radhakrishnan RC, Gopal B, Zachariah UG, Abraham P, Mohapatra A, Valson AT, Alexander S, Jacob S, Tulsidas KS, David VG, Varughese S Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of hypertension and its associated risk factors among medical students in Qassim University.
The objective of the study is to assess the prevalence of hypertension and its associated risk factors in medical students attending the College of Medicine in Qassim University, Qassim, Saudi Arabia. It is a cross-sectional study that was conducted during the year 2017 on medical students attending the College of Medicine at Qassim University. A total of 130 students were selected using multistage stratified random sampling. We collected data on sociodemographic information and risk factors using a self-administered questionnaire derived from the WHO STEPS instrument, and we measured the blood pressure and body mass index...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: AlWabel AH, Almufadhi MA, Alayed FM, Aloraini AY, Alobaysi HM, Alalwi RM Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury in intensive care unit, hospital Universiti Sains Malaysia: A descriptive study.
In conclusion, AKI developed more in male patients, Malay ethnicity, presented with comorbid, caused by sepsis, admitted to ICU, required mechanical ventilation, and need for renal replacement therapy. PMID: 30381507 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: Hamid SA, Adnan WW, Naing NN, Adnan AS Tags: Saudi J Kidney Dis Transpl Source Type: research