Study of Serum Fibroblast Growth Factor 23 as a Predictor of Endothelial Dysfunction among Egyptian Patients with Diabetic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):305-312. doi: 10.4103/1319-2442.395446. Epub 2024 Feb 12.ABSTRACTEndothelial dysfunction in patients with diabetic nephropathy is caused by nontraditional factors in addition to common risk factors (e.g., hypertension) in people with normal kidney function. These nontraditional factors include factors involved in mineral bone disease in these patients. One of these factors is fibroblast growth factor 23 (FGF-23). We aimed to evaluate the relationship between flow-mediated dilatation (FMD) as a measure of endothelial dysfunction and FGF-23. This was a cross-sectional observationa...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Ahmed Fayed AbdelAal Mohamed Rabab Mahmoud Ahmed Sameh Abouzeid Ahmed Soliman Source Type: research

Association between Hypertension and Atrial Fibrillation in Patients on Hemodialysis
This study aimed to evaluate the prevalence and the association between hypertension (HTN) and atrial fibrillation (AF) in hemodialysis (HD) patients. A chart review-based, cross-sectional study was conducted on HD patients who had received HD for at least 6 months. Demographic, hemodynamic, and laboratory data were retrieved from the BestCare system, and the main outcomes were blood pressure before and after dialysis, and the presence of AF. Our sample consisted of 304 HD patients; 162 (53%) were male, and the mean age was 63 ± 18 years. Sixty-eight (20%) had AF, of whom 44 (64.7%) were male, with a mean age of 73 ± 12 ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Alanoud Husain Almuhana Lolo Ibrahim Alkhwaiter Abeer Alghamdi Alreem Alsaleem Arwa Almehrij Mubarak Abdalla Abdulla Ahmed Al Sayyari Source Type: research

Relationship between High-density Lipoprotein Cholesterol and Insulin Resistance in Non-diabetic Chronic Kidney Disease Patients
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):323-330. doi: 10.4103/1319-2442.395448. Epub 2024 Feb 12.ABSTRACTInsulin resistance is linked to cardiovascular disease (CVD), even in non-diabetic patients. Therefore, insulin resistance contributes to the development of CVDs, which are the most important cause of morbidity and mortality in chronic kidney disease (CKD) and patients receiving dialysis replacement therapy. Furthermore, CKD greatly affects the enzyme activities responsible for the metabolism of high-density lipoprotein (HDL), causing an abnormal composition and function of HDL, which results in the loss of the ant...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Yasser Abdel-Monem El-Hendy Mabrouk Ibrahim Ismail Maher Mohamed Borai Walid Ahmed Ragab Abdelhamid Source Type: research

Prevalence and Risk Factors of New-onset Diabetes after Transplant in East Africans
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):331-336. doi: 10.4103/1319-2442.395449. Epub 2024 Feb 12.ABSTRACTVery little is known about the prevalence of new-onset diabetes after transplant (NODAT) in sub-Saharan and Eastern Africans. Most of the data are related to African Americans and to North and South Africans. The aims of this study were to examine the prevalence of NODAT in Sudanese renal transplant recipients, compare it with the published literature, and identify the risk factors for developing NODAT. In total, 150 patients who received a living-related kidney transplant between January 2015 and January 2016 were...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Salsabil Osman Nasir Helen McCarthy Ihab Abdel-Rahim Mohamed Ahmed Source Type: research

Clinicopathological Profile of Immunoglobulin A Nephropathy: A Study from Northeast India
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):337-345. doi: 10.4103/1319-2442.395450. Epub 2024 Feb 12.ABSTRACTImmunoglobulin A (IgA) nephropathy is the most common primary glomerulopathy, with wide variation in its prevalence as well as clinical symptoms. Among the laboratory parameters, increased serum creatinine (SCr) levels, mean arterial pressure (MAP), and a decreased estimated glomerular filtration rate (eGFR) point toward poorer renal function. The Oxford 2016 scoring system for IgA nephropathy identified various histopathological variables, which serve as indicators of renal outcomes. There is a paucity of studies ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Pranjal Kalita Jaya Mishra Biswajit Dey Vandana Raphael Monaliza Lyngdoh Himesh Barman Animesh Mishra Source Type: research

Spectrum and Distribution of Biopsy-proven Kidney Diseases: A 12-year Survey of a Single Center in Iran
This study aimed to analyze the prevalence of biopsy-proven kidney diseases in Iran's primary referral center. To the best of our knowledge, this is the most extensive study carried out in Iran. Reports of kidney biopsy samples from patients referred to our center in 2007-2018 were reviewed for demographic data, clinical presentation, and final diagnosis. Statistical analyses were performed. Among the 3455 samples received, 2975 were analyzed. Nephrotic syndrome (39%) was the most common cause of biopsy, followed by subnephrotic proteinuria (18%), hematuria in association with proteinuria (15%), renal failure (9%), isolate...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Fatemeh Nili Elham Farahani Mehran Moghimian Issa Jahanzad Farzaneh-Sadat Minoo Samaneh Salarvand Alireza Abdollahi Seyed Ali Mirshahvalad Source Type: research

Renal Survival of Chronic Kidney Disease Patients in a Tertiary Referral Hospital in Malaysia
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):355-364. doi: 10.4103/1319-2442.395452. Epub 2024 Feb 12.ABSTRACTChronic kidney disease (CKD) represents a major public health issue, which then progresses to end-stage renal disease (ESRD) sooner or later. This retrospective cohort study aimed to determine the renal survival time of CKD patients. In total, 247 CKD patients in one of the tertiary referral hospitals in Malaysia between January 2005 and December 2015 were enrolled. All CKD patients were included if they were dependent on dialysis. Patients who were transferred out and those with incomplete records were excluded fr...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Farhanah Omar Fatin Ab-Hamid Siti Azrin Bachok Norsa'adah Azreen Syazril Adnan Wan-Adnan Wan Nor Asyikeen Source Type: research

Successful Treatment and Long-term Follow-up of a Rhodococcus equi Brain Abscess in a Renal Transplant Recipient
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):365-370. doi: 10.4103/1319-2442.395453. Epub 2024 Feb 12.NO ABSTRACTPMID:38345592 | DOI:10.4103/1319-2442.395453 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Zaheer Udin Babar Asma Nasim Sunil Kumar Dodani Tahir Aziz Source Type: research

Renal Allograft Malakoplakia Presenting as a Pseudotumoral Lesion
We describe a case of grafi malakoplakia in an adult female, who presented with dull aching pain in the right loin, fever, and vomiting. Ultrasonography of the kidney graft showed a heterogeneous lesion (2.6 cm × 2.9 cm), raising suspicion of primary or metastatic renal tumors. The diagnosis was established after a histopathological examination of the kidney biopsy. This pseudotumoral presentation of malakoplakia can mimic renal cell carcinoma, lymphoma, fungal infections, or tuberculosis. It is essential to perform a biopsy for establishing the diagnosis.PMID:38345593 | DOI:10.4103/1319-2442.395454 (Source: Saudi Journal...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Vikarn Vishwajeet Aasma Nalwa Mahendra Kumar Jangid Gautam Ram Choudhary Pushpinder Khera Nitin Bajpai Poonam Abhay Elhence Source Type: research

Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):279-287. doi: 10.4103/1319-2442.395443. Epub 2024 Feb 12.ABSTRACTHyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the de...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Shankar Prasad Nagaraju Srinivas Vinayak Shenoy Indu Rao Ravindra Attur Prabhu Dharshan Rangaswamy Mohan V Bhojaraja Vasudeva Guddattu Source Type: research

Comparing the Effect of Local Application of Peppermint and Cold Compresses on the Severity of Pain from Venipuncture in Dialysis Patients: A Parallel Randomized Clinical Trial Study
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):288-296. doi: 10.4103/1319-2442.395444. Epub 2024 Feb 12.ABSTRACTPain at the injection site is one of the most common complaints in the clinic and is the most important symptom affecting the quality of life of hemodialysis (HD) patients. The aim of this study was to determine the effect and compare the topical application of peppermint and cold compresses on the intensity of pain caused by the insertion of a needle into the fistula of HD patients. In this parallel randomized clinical trial, 99 HD patients were assigned to three groups receiving peppermint, a cold compress, or a ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Bita Koushki Mahboobeh Khajeh Hossein Bagheri Seyedeh Solmaz Talebi Hossein Ebrahimi Source Type: research

Acute Kidney Injury in Acute Myocardial Infarction and Its Outcome at 3 and 6 Months
According to this study, if indicated, a percutaneous coronary intervention should not be denied to patients for fear of developing AKI. This needs to be examined in larger randomized trials.PMID:38345584 | DOI:10.4103/1319-2442.395445 (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Jaspreet Kaur Nidhi Bhardwaj Sreenivas Reddy Sanjay D'Cruz Source Type: research

Study of Serum Fibroblast Growth Factor 23 as a Predictor of Endothelial Dysfunction among Egyptian Patients with Diabetic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):305-312. doi: 10.4103/1319-2442.395446. Epub 2024 Feb 12.ABSTRACTEndothelial dysfunction in patients with diabetic nephropathy is caused by nontraditional factors in addition to common risk factors (e.g., hypertension) in people with normal kidney function. These nontraditional factors include factors involved in mineral bone disease in these patients. One of these factors is fibroblast growth factor 23 (FGF-23). We aimed to evaluate the relationship between flow-mediated dilatation (FMD) as a measure of endothelial dysfunction and FGF-23. This was a cross-sectional observationa...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Ahmed Fayed AbdelAal Mohamed Rabab Mahmoud Ahmed Sameh Abouzeid Ahmed Soliman Source Type: research

Association between Hypertension and Atrial Fibrillation in Patients on Hemodialysis
This study aimed to evaluate the prevalence and the association between hypertension (HTN) and atrial fibrillation (AF) in hemodialysis (HD) patients. A chart review-based, cross-sectional study was conducted on HD patients who had received HD for at least 6 months. Demographic, hemodynamic, and laboratory data were retrieved from the BestCare system, and the main outcomes were blood pressure before and after dialysis, and the presence of AF. Our sample consisted of 304 HD patients; 162 (53%) were male, and the mean age was 63 ± 18 years. Sixty-eight (20%) had AF, of whom 44 (64.7%) were male, with a mean age of 73 ± 12 ...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Alanoud Husain Almuhana Lolo Ibrahim Alkhwaiter Abeer Alghamdi Alreem Alsaleem Arwa Almehrij Mubarak Abdalla Abdulla Ahmed Al Sayyari Source Type: research

Relationship between High-density Lipoprotein Cholesterol and Insulin Resistance in Non-diabetic Chronic Kidney Disease Patients
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):323-330. doi: 10.4103/1319-2442.395448. Epub 2024 Feb 12.ABSTRACTInsulin resistance is linked to cardiovascular disease (CVD), even in non-diabetic patients. Therefore, insulin resistance contributes to the development of CVDs, which are the most important cause of morbidity and mortality in chronic kidney disease (CKD) and patients receiving dialysis replacement therapy. Furthermore, CKD greatly affects the enzyme activities responsible for the metabolism of high-density lipoprotein (HDL), causing an abnormal composition and function of HDL, which results in the loss of the ant...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Yasser Abdel-Monem El-Hendy Mabrouk Ibrahim Ismail Maher Mohamed Borai Walid Ahmed Ragab Abdelhamid Source Type: research