Interleukin-6 -174G/C polymorphism and end-stage renal disease: Is there any role?
PMID: 29970762 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Srriwijitalai W, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Transplant recipients with cytomegalovirus and BK polyomavirus coinfection nephropathy.
PMID: 29970763 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Yasri S, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

What we do and do not know about women and kidney diseases; Questions unanswered and answers unquestioned: Reflection on World Kidney Day and International Woman's Day.
Abstract Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% ...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Piccoli GB, Alrukhaimi M, Liu ZH, Zakharova E, Levin A Tags: Saudi J Kidney Dis Transpl Source Type: research

Atypical hemolytic uremic syndrome: Laboratory characteristics, complement-amplifying conditions, renal biopsy, and genetic mutations.
This article focuses on the role of four distinct aspects of aHUS that assist clinicians in making an accurate diagnosis of aHUS. First, because of the lack of a single specific laboratory test for aHUS, other forms of thrombotic microangiopathies such as thrombotic thrombocytopenic purpura and Shiga toxin-associated HUS must be excluded to successfully establish the diagnosis of aHUS. Second, application of the knowledge of complement-amplifying conditions is critically important in making an accurate diagnosis. Third, when available, a renal biopsy can reveal changes consistent with thrombotic microangiopathy. Fourth, ge...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Hossain MA, Cheema A, Kalathil S, Bajwa R, Costanzo EJ, Cosentino J, Cheng J, Vachharajani T, Asif A Tags: Saudi J Kidney Dis Transpl Source Type: research

Association of brucellosis with renal tubular and glomerular damage in children in Turkey.
Abstract Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Until now, no studies have been performed on renal tubular disorders in patients with brucellosis. The present study aims to investigate renal tubular disorders in patients with brucellosis. This prospective case-control study includes a total of 31 brucellosis patients (Group 1) and 30 healthy controls (Group 2) matched for age and sex. Renal tubular functions of children who were diagnosed as having brucellosis in outpatient pediatric clinics were evaluated. First-morning urine samples were collected ...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Conkar S, Kosker M, Cevik S, Ay M Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of serum soluble urokinase plasminogen activator receptor as a marker for steroid-responsiveness in children with primary nephrotic syndrome.
Abstract Nephrotic syndrome (NS) is the most common primary glomerular disease among children. It runs a relapsing course involving prolonged periods of treatment with corticosteroids and other immunosuppressive medications. Soluble urokinase plasminogen activator receptor (suPAR) has been regarded as an inflammatory as well as a permeability factor. The aim of our study was to evaluate serum suPAR levels in children with NS and its relation to steroid responsiveness. Our study was carried out on 75 children who were already diagnosed as having NS; they were classified into three groups (steroid sensitive, steroid...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Mousa SO, Saleh SM, Aly HM, Amin MH Tags: Saudi J Kidney Dis Transpl Source Type: research

Atypical hemolytic uremic syndrome: A monocentric adult Tunisian study and review of literature.
Abstract Atypical hemolytic uremic syndrome (aHUS) is characterized by microvascular thrombosis resulting in thrombocytopenia, hemolytic anemia, and multiorgan dysfunction. It is associated with genetic or acquired disorders of regulatory components of the complement system. For our study, we collected data from 16 patients diagnosed with aHUS between January 2010 and January 2014. The mean age was 33.6 years. The female-to-male ratio was 3. The median follow-up duration was 27 ± 3.5 months. The most common clinical presentation was hypertension. Renal involvement was noted in all cases. Ten patients had ex...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Kherder-Elfekih R, Hajji M, Fatma LB, Jebali H, Mami I, Smaoui W, Krid M, Rais L, Beji S, Zouaghi K, Sellami-Kallel M Tags: Saudi J Kidney Dis Transpl Source Type: research

ADAMTS-13 level in children with severe diarrhea-associated hemolytic uremic syndrome: Unmasking new association.
This study aimed to evaluate the ADAMTS-13 level in severe typical HUS. This prospective case-control study was carried out in the Pediatric Nephrology Unit and Clinical Pathology Department, Faculty of Medicine, Zagazig University from February 2013 to February 2014. The study included 15 consecutive children with typical HUS as well as 15 healthy children as a control group. Routine laboratory investigations were performed. Assessment of serum ADAMTS-13 level was performed using the Quantikine human ADAMTS-13 ELISA kit. Data were analyzed using Statistical Package for Social Sciences version 16. Nonparametric values were...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Khalifa NA, Gawish HH, Khalifa NA, Tawfeek DM, Morsy SM Tags: Saudi J Kidney Dis Transpl Source Type: research

Scoring systems and outcome of chronic kidney disease patients admitted in intensive care units.
This study assessed the outcome of CKD patients admitted to the ICU and evaluated prediction of 30-day mortality using the Acute Physiology and Chronic Health Evaluation (APACHE II), Simplified Acute Physiology Score (SAPS II), and Sequential Organ Failure Assessment (SOFA) score. One hundred consecutive CKD patients admitted to the ICU at a tertiary care hospital, Ahmedabad between 2011 and 2013 were included prospectively. Data on demographics, indication for admission, cause of CKD, use of vasoactive drugs and mechanical ventilation (MV), mode of renal replacement therapy (RRT), and 30-day mortality were recorded. The A...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Goswami J, Balwani MR, Kute V, Gumber M, Patel M, Godhani U Tags: Saudi J Kidney Dis Transpl Source Type: research

Impact of body mass index on progression of primary immunoglobulin a nephropathy.
Abstract The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study. We defined two groups of p...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Nagaraju SP, Rangaswamy D, Mareddy AS, Prasad S, Kaza S, Shenoy S, Saraf K, Attur RP, Parthasarathy R, Kosuru S, Mateti UV, Guddattu V, Koulmane Laxminarayana SL Tags: Saudi J Kidney Dis Transpl Source Type: research

Complementary bodybuilding: A potential risk for permanent kidney disease.
We report our experience of renal disease associated with bodybuilders who had been on high-protein diet, anabolic androgenic steroids (AASs), and growth hormone (GH) for years. A total of 22 adult males who volunteered information about use of high protein diet and AAS or GH were seen over a six-year period with renal disease. Kidney biopsy revealed focal segmental glomerulosclerosis (FSGS) in eight, nephroangiosclerosis in four, chronic interstitial nephritis in three, acute interstitial nephritis in two, nephrocalcinosis with chronic interstitial nephritis in two, and single patients with membranous glomerulopathy, cres...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: El-Reshaid W, El-Reshaid K, Al-Bader S, Ramadan A, Madda JP Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence of malnutrition in hemodialysis patients: A single-center study in Palestine.
Abstract Only a few studies have been published on the nutritional status of hemodialysis (HD) patients in Arab countries. The aim of this study was to determine the nutritional status and prevalence of malnutrition and its predictors among HD patients at An-Najah National University Hospital, Nablus, Palestine. A cross-sectional study was carried out on HD patients in this hospital. Seven-Point Subjective Global Assessment (7-point SGA) was used to assess the nutritional state of HD patients. Biochemical tests were obtained during the study period from medical files of the studied patients. A total of 106 HD pati...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Rezeq HA, Khdair LN, Hamdan ZI, Sweileh WM Tags: Saudi J Kidney Dis Transpl Source Type: research

Outcomes of immunosuppression in IgA nephropathy based on the oxford classification.
Abstract Numerous studies have addressed the predictive value of pathology findings from the Oxford Classification. Whether this influences treatment choice has not been determined. We evaluated patients with IgA nephropathy who were immunosuppressed and correlated our findings with both clinical and histological features as per the Oxford Classification. This was a retrospective observational study of 45 patients who had biopsy-proven IgA nephropathy with a mean follow-up of 2.6 years. Primary outcomes were time to end-stage renal disease (ESRD) or a 50% rise in serum creatinine. Immunosuppression was not associa...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Palamuthusingam D, Castledine C, Lawman S Tags: Saudi J Kidney Dis Transpl Source Type: research

The development of malnutrition is not dependent on its traditional contributing factors in patients on maintenance hemodialysis in developing countries.
Abstract Malnutrition in dialysis population is associated with significant morbidity and mortality. Nutritional assessment is a neglected area in hemodialysis (HD) patients in developing countries. The aim of the study was to find out whether any traditional parameters have statistically significant correlation with malnutrition. All 58 end-stage renal disease patients on maintenance HD in our dialysis unit were enrolled in this cross-sectional study. The nutritional status was assessed by a predesigned questionnaire including subjective global assessment (SGA). Anthropometric measurements, peripheral neuropathy,...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Ali Bokhari SR, Faizan Ali MA, Khalid SA, Iftikhar B, Ahmad HI, Hussain AS, Yaqoob U Tags: Saudi J Kidney Dis Transpl Source Type: research

Urinary tract infection in renal transplant recipients at a tertiary care center in India.
Abstract Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts. Forty-nine patients had primary infection while 20 patients had recu...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Mukherjee D, Sharma S, Nair RK, Datt B, Arora D, Rao A Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation and comparison of the effects of Xyla-P cream and cold compress on the pain caused by the cannulation of arteriovenous fistula in hemodialysis patients.
This study aimed to investigate and compare the effects of Xyla-P cream and cold compress on the pain caused by the insertion of a needle into the arteriovenous fistula (AVF) in hemodialysis (HD) patients. This clinical trial was conducted on HD patients who were selected using simple random sampling method. Using a visual analog scale, pain intensity was measured during two HD sessions in three stages including after the application of a placebo, after application of Xyla-P cream, and after the application of cold compress. The collected data were analyzed using descriptive statistics and repeated measures analysis of var...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Ghoreyshi Z, Amerian M, Amanpour F, Ebrahimi H Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison of intradermal route and dose of Hepatitis B vaccine administration in chronic dialysis patients: A pilot study.
Abstract We aimed to study the seroconversion rate in two arms of intradermal (ID) route: low dose with high-frequency and high dose with low-frequency hepatitis B (HB) vaccination in dialysis patients. A total of 56 patients, on either hemodialysis or peritoneal dialysis, were included. Patients were enrolled and randomized into two groups. The first group was immunized through the ID route and received weekly 10 μg of vaccine at 0, 1, 2, 3, 4, 5, 6, and 7 weeks (low-dose with high frequency). The second group was immunized through the ID route and received two doses of 40 μg at one-month interval (high dos...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Jhorawat R, Shah P, Beniwal P, Agarwal D, Nijhawan S, Malhotra V Tags: Saudi J Kidney Dis Transpl Source Type: research

Adoption of transposed basilic vein as access for hemodialysis.
This study shows that adoption of TBV reduces the need for AVG. To improve TBV access maturation and survival, it is necessary to consider adopting a selection criteria based on findings on vessel mapping. PMID: 29657207 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Akoh JA Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal amyloidosis in ankylosing spondylitis: A monocentric study and review of literature.
Abstract Secondary renal amyloidosis (RA) is the most common type of renal involvement in ankylosing spondylitis (AS). We assessed the epidemiologic and clinico-biological profile of AS patients with RA, to analyze treatment modalities and prognostic aspects, and to determine predictive factors of RA during AS. This was a retrospective study including 13 cases of RA among 212 cases who presented with AS, during the period from 1978 to 2006. The median age of the patients at the time of diagnosing AS was 47 years (range: 19-67). There were 11 males and two females. RA onset was diagnosed after a mean follow-up of 1...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Barbouch S, Hajji M, Jaziri F, Aoudia R, Fellah E, Hedri H, Goucha R, Hamida FB, Taarit FB, Gorsane I, Abdallah TB Tags: Saudi J Kidney Dis Transpl Source Type: research

Spectrum of biopsy-proven renal diseases: A single center experience.
This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12.22%) and tubulointerstitial diseases (10%). The IgA nephropathy (IgAN) was the most common PGD and majority had mesangial hypercellularity (M1) (93.54%), tubular atrophy (T1 or T2 68.25%), and the most common pattern was M1, E0, S0, and T1, suggesting that pat...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Gopaliah LR, Sudakaran I, Nalumakkal SV, Narayanan R, Vareed BM Tags: Saudi J Kidney Dis Transpl Source Type: research

Refusal of hemodialysis by hospitalized chronic kidney disease patients in Pakistan.
Abstract In Pakistan, patients with chronic kidney disease (CKD) are commonly diagnosed at a late stage. There is little information about the refusal of hemodialysis by hospitalized CKD patients who need hemodialysis (HD) and reasons for acceptance and refusal among these patients. All patients with Stage V CKD who had medical indications to undergo HD and were hospitalized at a tertiary care facility over a six-month period were invited to participate in this study. Patients were surveyed regarding acceptance or refusing of HD and reasons for their decisions. Demographic, socioeconomic, and clinical characterist...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Shafi ST, Saleem M, Anjum R, Abdullah W, Shafi T Tags: Saudi J Kidney Dis Transpl Source Type: research

Etiological profile of chronic kidney disease: A single-center retrospective hospital-based study.
This study was performed to evaluate the various etiologies of CKD among patients presenting to the Department of Nephrology, Guwahati Medical College, a tertiary referral center. A total of 5718 CKD patients were evaluated to identify the cause of CKD. The most common cause was found to be diabetes mellitus in 42.2%, followed by chronic glomerulonephritis in 21.4%, hypertension in 19.5%, obstructive uropathy in 6.9%, chronic interstitial nephritis in 3.6%, and autosomal dominant polycystic kidney disease in 1.5% of the patients. Nearly 2.7% of the patients had CKD of unknown etiology. Most of the common causes of CKD are ...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Sharma M, Doley P, Das HJ Tags: Saudi J Kidney Dis Transpl Source Type: research

Mortality in the elderly with acute kidney injury in an internal medicine department in Abidjan, Cote D'Ivoire.
The objective of this study is to identify the causes of death in the elderly with AKI. This is a prospective cohort study with a descriptive purpose which was carried out during the period from January 2009 to December 2014 in the Department of Nephrology-Internal Medicine of Treichville University Hospital. The diagnosis of AKI was made on the basis of serum creatinine (SCr) values determined during hospitalization, according to KDIGO classification. Our study involved 107 elderly aged 65 and older with AKI. The hospital mortality rate was 46.7% (50/107). The average age of deceased patients was 71.8 ± 7 years wit...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Yao HK, Omer Binan AY, Konan SD, N'Da KJ, Diopoh SP Tags: Saudi J Kidney Dis Transpl Source Type: research

Reactive perforating collagenosis: An important differential diagnosis in hemodialysis patients.
Abstract This is a case report of a 68-year-old hypertensive, diabetic woman who was on regular thrice weekly hemodialysis (HD). She presented with gradually worsening left lower limb pain and swelling. Clinical examination revealed significant edema over the left calf and ankle joint with significant calf tenderness. Extensive workup including magnetic resonance imaging of the lower limb and venous Doppler failed to show any significant abnormality. In view of developing papular lesions over the area, skin biopsy was performed, which finally confirmed reactive perforating collagenosis. This diagnosis ensured reas...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Dey AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Kaposi's sarcoma in patients with membranous nephropathy.
In this report, a patient with membranous glomerulonephritis that accepted long-term prednisolone and cyclosporine immunosuppressive therapy developed skin KS. Withdrawal of immunosuppressive treatment resulted in the disappearance of KS. PMID: 29657214 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Liu W, Lin F, Chen X, Wei L, Wu J Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute gastric dilatation in a patient with lupus nephritis: An uncommon presentation of lupus mesenteric vasculitis.
Abstract Abdominal symptoms are common in patients with lupus nephritis and are often attributed to drugs or uremia per se. Lupus mesenteric vasculitis (LMV) or lupus enteritis is a rare entity reported in patients with active systemic lupus erythematosus. It usually occurs in patients with a long-standing history of lupus with high disease activity. Usually, small bowel is predominantly affected. The stomach and rectum are spared in view of significant collateral circulation. Here, we describe an 18-year-old boy who presented with nephrotic syndrome without any extrarenal features of lupus. On subsequent evaluati...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Ezhilnilavan S, Priyamvada PS, Haridasan S, Rajesh NG, Parameswaran S Tags: Saudi J Kidney Dis Transpl Source Type: research

Colistin-induced myasthenic syndrome in a patient with end-stage renal disease.
Abstract With resurgence of multidrug resistance (MDR) bacteria and no new novel broad-spectrum antibiotic in research pipeline, usage of older generation antibiotics, once discarded due to their toxicity profile are becoming popular again. Often these drugs are the only option left in managing MDR bacteria-related sepsis. Colistin is one of such antibiotic which is often used in recent times after decades of its avoidance due to its diverse toxicity profile. In this case report, we present a rare myasthenic syndrome like neuromuscular complication developed in a patient after receiving colistin for treatment of M...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Sengupta P, Biswas S Tags: Saudi J Kidney Dis Transpl Source Type: research

Systemic lupus erythematosus with Sj ögren's syndrome and renal tubular acidosis presenting as nephrogenic diabetes insipidus.
We report a case who presented with DI (nephrogenic) and fulfilled criteria for SLE and Sjögren's syndrome with renal tubular acidosis. PMID: 29657217 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Parrey AH, Ahmad F, Ahmad M, Basher A Tags: Saudi J Kidney Dis Transpl Source Type: research

Rapidly progressive glomerulonephritis: A wild card manifestation of lupus nephritis.
Abstract A significant proportion of individuals with systemic lupus erythematosus (SLE) will have clinical or laboratory evidence of renal involvement at some point in the course of their disease. Lupus nephritis (LN) is one of the more important systemic manifestations of SLE and although progression to end-stage renal disease (ESRD) is not usually the norm, a significant minority of patients will do so, some in a rather dramatic fashion. It is in such instances that LN constitutes a true nephrologic emergency. Gratifyingly, it is rarely a silent emergency and heightened awareness amongst clinicians about its un...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Komolafe OO Tags: Saudi J Kidney Dis Transpl Source Type: research

Paraneoplastic glomerulopathies associated with hematologic malignancies.
We present three cases of paraneoplastic NS associated with hematological malignancies. Early diagnosis and treatment can alter prognosis of these patients. Paraneoplastic syndromes would remit only with proper treatment of the neoplasia. PMID: 29657219 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Dhanapriya J, Dineshkumar T, Sakthirajan R, Surendar D, Gopalakrishnan N, Balasubramaniyan T Tags: Saudi J Kidney Dis Transpl Source Type: research

Complete remission of nephrotic syndrome secondary to amyloid a amyloidosis in patient with inactive Crohn's disease after treatment by infliximab.
We present a case of a 34-year-old female patient with CD treated by azathioprine with inactive disease for three years and who developed a nephrotic syndrome secondary to AA amyloidosis. The treatment by infliximab for one year leads to a complete remission of the nephrotic syndrome. In this case, this complication occurred while the patient was clinically well, with biological and endoscopic markers showing an inactive or only mildly active disease. Infliximab could be a useful tool for a successful treatment of amyloidosis secondary to CD. PMID: 29657220 [PubMed - in process] (Source: Saudi Journal of Kidney Diseas...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Hassani K, Hamzi MA, El Kabbaj D Tags: Saudi J Kidney Dis Transpl Source Type: research

Unusual cause of crystalline nephropathy.
We report a 23-year-old female with acute renal failure and nephrotic proteinuria. Urinalysis showed reddish brown, round crystals with dark outline, and central spicules consistent with 2,8-DHA crystals. Renal biopsy showed membranous nephropathy and 2,8-DHA nephropathy. Our patient improved with liberal fluid intake, restriction of high adenine content foods, and oral xanthine dehydrogenase inhibitor febuxostat. Early diagnosis and initiation of treatment prevent renal complications. PMID: 29657221 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Gopalakrishnan N, Rajasekar D, Dhanapriya J, Dineshkumar T, Sakthirajan R, Balasubramaniyan T, Murugesan V Tags: Saudi J Kidney Dis Transpl Source Type: research

Management of Salmonella peritonitis in a patient on peritoneal dialysis without catheter removal.
Abstract Peritoneal dialysis (PD)-associated peritonitis is an important contributor to morbidity and mortality; Gram-positive bacteria constitute the most frequent associated pathogens (45%-60%) followed by Gram-negative bacteria (25%-40%) and fungal infection (3%-6%). Salmonella peritonitis is an extremely rare cause of peritonitis (0.15%). Peritonitis attributed to Salmonella has been reported only in four cases. Herewith, we report a 68-year-old Sudanese female who presented to our PD unit with abdominal pain and diarrhea and was diagnosed to have Salmonella peritonitis. She was managed without catheter remova...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Al-Zahrani FF, Al-Shahrani H, Al-Mohawes A, Al-Hwiesh A, Noor A, Abdulrahmn IS Tags: Saudi J Kidney Dis Transpl Source Type: research

Distal renal tubular acidosis in Sj ögren's syndrome.
Distal renal tubular acidosis in Sjögren's syndrome. Saudi J Kidney Dis Transpl. 2018 Mar-Apr;29(2):470-473 Authors: Narayan R, Abdulla MC, Alungal J, Krishnadas NC Abstract Interstitial nephritis and immune complex-mediated glomerulonephritis are the two common renal manifestations of primary Sjögren's syndrome (SS). Here, we discuss three cases of primary SS where presenting manifestation was distal renal tubular acidosis. The possibility of an underlying autoimmune disorder should be considered in a patient presenting with distal tubular acidosis or recurrent hypokalemic periodic paralysi...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Narayan R, Abdulla MC, Alungal J, Krishnadas NC Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison between adjuvanted and nonadjuvanted influenza vaccination among patients undergoing hemodialysis: A cost-effectiveness analysis from Thailand.
PMID: 29657224 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Joob B, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Cost-effectiveness analysis of common tuberculosis screening laboratory tests for hemodialysis patients: An analysis from tropical endemic country, Thailand.
PMID: 29657225 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Srriwijitalai W, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

The association between apolipoprotein E polymorphism and diabetic nephropathy in Iranian patients.
PMID: 29657226 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Abedini A, Roomizadeh P Tags: Saudi J Kidney Dis Transpl Source Type: research

Author's reply.
PMID: 29657227 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Razi F Tags: Saudi J Kidney Dis Transpl Source Type: research

Human babesiosis, renal failure, and dialysis: A summary and comment on forgotten disease.
PMID: 29657228 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Sriwijitalai W, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Sunitinib therapy as a cause of diffuse digestive tract hemorrhage in end-stage renal disease patient.
PMID: 29657229 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Taki Y, Imai N, Kojima S, Kaneshiro N, Shibagaki Y Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal failure in advanced cholangiocarcinoma: Magnitude.
PMID: 29657230 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2018 Category: Urology & Nephrology Authors: Sookaromdee P, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Contrast-induced nephropathy: Pathophysiology, risk factors, and prevention.
Abstract Contrast-induced acute kidney injury is a common iatrogenic complication associated with increased health resource utilization and adverse outcomes, including short- and long-term mortality and accelerated progression of preexisting renal insufficiency. The incidence of contrast-induced nephropathy (CIN) has been reported to range from 0% to 24%. This wide range reported by the studies is due to differences in definition, background risk factors, type and dose of contrast medium used, and the frequency of other coexisting potential causes of acute renal failure. CIN is usually transient, with serum creati...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Hossain MA, Costanzo E, Cosentino J, Patel C, Qaisar H, Singh V, Khan T, Cheng JS, Asif A, Vachharajani TJ Tags: Saudi J Kidney Dis Transpl Source Type: research

Effect of vitamin E on reversibility of renal function following discontinuation of colistin in rats: Histological and biochemical investigations.
This study was carried out to evaluate spontaneous renal regeneration after stopping colistin methanesulfonate (CMS), which induces tubular damage, and the curative effect of Vitamin E (vit E) in rats. Animals were given the following: sterile saline (n = 6), 300,000 IU/kg/ day of CMS (n = 24), or 450,000 IU/kg/day of CMS (n = 24) for seven days. Each CMS group was subdivided into four subgroups (n = 6) and sacrificed as follows: (i) 12 h after stopping CMS, (ii) two weeks after stopping CMS, (iii) two weeks after stopping treatment with vit E, and (iv) two weeks after stopping treatment with olive oil. Subsequently, plasm...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Ghlissi Z, Hakim A, Mnif H, Kallel R, Zeghal K, Boudawara T, Sahnoun Z Tags: Saudi J Kidney Dis Transpl Source Type: research

Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress in rat.
Abstract Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueous-ethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N. sativa (100, 200 mg/kg). Du...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Hosseinian S, Hadjzadeh MA, Roshan NM, Khazaei M, Shahraki S, Mohebbati R, Rad AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Mutational analysis of AGXT gene in Libyan children with primary hyperoxaluria type 1 at Tripoli Children Hospital.
Abstract Primary hyperoxaluria type 1 (PH1) is an inborn error of glyoxylate metabolism. It results from genetic mutation of the AGXT gene. The study objective was to verify the clinical and epidemiological patterns of PH1 in Libyan children at Tripoli Children Hospital confirmed by AGXT gene mutation. A descriptive case series study of 53 children with PH1 diagnosed between 1994 and 2015 was carried out in the Nephrology Unit at Tripoli Children Hospital. Diagnosis of PH1 was based on the clinical presentation (renal stones or nephrocalcinosis), positive family history of PH1, and high 24 h urinary oxalate. Sampl...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Rhuma NR, Fituri OA, Sabei LT Tags: Saudi J Kidney Dis Transpl Source Type: research

C4d-negative antibody-mediated rejection: A pathologist's perspective and clinical outcome.
We present a retrospective study to determine the incidence and outcome of C4d-negative ABMR. A total of 987 renal allograft (RA) biopsies obtained from 987 RA recipients were studied from January 2013 to January 2016. All samples were subjected to light microscopy using standard stains and C4d immunohistochemistry on paraffin sections and reported according to modified Banff's criteria. Adequate biopsies with immunological injuries were categorized as Group 1: pure ABMR, Group 2: combined ABMR with concurrent T-cell-mediated rejection (TCR), and Group 3: pure TCR. Groups 1 and 2 were further subgrouped as C4d positive (Gr...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Nigam LK, Vanikar AV, Kanodia KV, Patel RD, Suthar KS, Patel HV Tags: Saudi J Kidney Dis Transpl Source Type: research

Medical renal disease in tumor nephrectomies: The silent killer.
Abstract In tumor nephrectomy specimens, the evaluation of the normal renal parenchyma is often overlooked. A patient with both end-stage renal diseases (ESRDs) with a renal cell carcinoma is more likely to die of the ESRD rather than cancer. At the time of nephrectomy, a pathologist has a large amount of tissue available to him to comment upon the presence of disease in the nonneoplastic kidney. Hence, this study was undertaken with the idea of characterizing disease in the nonneoplastic kidney at the time of tumor nephrectomy. A two-year retrospective study was carried out on all tumor nephrectomies and partial ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Tewari R, Bajaj R, Bharadwaj R Tags: Saudi J Kidney Dis Transpl Source Type: research

Morbidity and mortality of hospitalized hip fractures in chronic hemodialysis.
Abstract Abnormal bone architecture contributes to high incidence of hip fractures in chronichemodialysis (HD) patients. Their clinical epidemiology is incompletely described. We conducted a retrospective cohort study to assess the implications ofhospitalization with hip fracture in HD patients compared to the nonchronic kidney disease population. Thirty-three chronic HD patients admitted with hip fracture overfiveyears were age- and sex-matched on a 1:1 ratio with controls that had hip fracture and normal renal function. Demographic characteristics, deaths, and readmissions atsixmonths,hospitalization length, tim...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Vlachopanos G, Kassimatis T, Kokkona A, Zerva A, Stavroulaki E, Zacharogiannis C, Agrafiotis A Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of prevalence and clinical outcome of frailty in an elderly predialysis cohort using simple tools.
Abstract The relationship between frailty and chronic kidney disease in elderly population has been recognized; however, studies concentrating on frailty in predialysis patients are limited. For nephrologists, the recognition of frailty is important as it has impact on decisions on the choice of dialysis modality and sometimes on whether dialysis is indeed in the patients' best interests. Many of the tools for routine assessment of frailty are not easily applicable to those clinicians not practicing elderly care medicine. A tool needs to be simple and applicable for daily routine practice. The aim of this study wa...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Ali H, Abdelaziz T, Abdelaal F, Baharani J Tags: Saudi J Kidney Dis Transpl Source Type: research

Appraising the outcome and complications of peritoneal dialysis patients in self-care peritoneal dialysis and assisted peritoneal dialysis: A 5-year review of a single Saudi center.
Abstract Our objective is to study the outcomes and complications of peritoneal dialysis (PD) including comparison of self-care PD with home-care assisted PD during a five-year period. A retrospective study of PD data at King Saud University-affiliated hospital in Riyadh from January 1, 2009, to December 31, 2013. One hundred and eleven patients were included (female 55%). The average age was 47.4 (1-83) years. Twenty-one (18.91%) patients were on continuous ambulatory PD and 90 (81.08%) on automated PD. The mean time on PD was 23.5 (3-60) months. At the end of five years, 47 (42.34%) patients were continuing on P...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Al Wakeel JS, Al Ghonaim MA, Aldohayan A, Usama S, Al Obaili S, Tarakji AR, Alkhowaiter M Tags: Saudi J Kidney Dis Transpl Source Type: research