A narrative review of the impacts of income, education, and ethnicity on arterial hypertension, diabetes mellitus, and chronic kidney disease in the world.
The objective of the present study was to analyze the impact of income, education, and ethnicity in hypertension, diabetes mellitus (DM), and chronic kidney disease (CKD) in the world, through the narrative review of the literature and analyzing the social indicators HDI and IHDI of the countries analyzed. After analyzing 161 studies from 96 countries, we identified that income, education, and color impact on the prevalence, incidence, diagnosis, treatment, progression, and mortality of hypertension, DM, and CKD in both low- and middle-income countries' development, as well as high and very high human development. The HDI ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Tirapani LDS, Fernandes NMDS Tags: Saudi J Kidney Dis Transpl Source Type: research

Risk of obstructive sleep apnea among senegalese dialysis patients.
This study aimed to determine the prevalence and risk factors of OSAS in Senegalese dialysis patients. In a cross-sectional study including 128 patients (75 men and 53 women) dialyzed since ≥6 months in four dialysis units. Data were collected during the dialysis session in the units. OSAS was assessed with the Berlin Questionnaire. Factors associated with OSAS risk were identified by multivariate logistic regression. The mean age of patients was 46.8 ± 16.9 ¥16-85 years). OSAS was found in 53 patients (overall prevalence of 41.4%) with predominance among individuals aged ≥50 years (52.6%). Hypertension an...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Seck SM, Moussa Tondi ZM, Niang S, Ould Lemraboot AT, Ka EF Tags: Saudi J Kidney Dis Transpl Source Type: research

Predialysis nephrology care and its impact on initial vascular access type in hemodialysis patients in Jordan.
In conclusion, our study suggests that a large percentage did not have nephrology care before initiating dialysis. The ones who were seen by nephrology before dialysis were significantly more likely to initiate dialysis using an AVF. A national focus on improving nephrology referral in advanced CKD may allow better utilization of AVF as the method of access at dialysis initiation. PMID: 31696849 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Hamadah AM, Gharaibeh K Tags: Saudi J Kidney Dis Transpl Source Type: research

Living-unrelated kidney donor transplantation: Legalization in exceptional circumstances?
Abstract The prevalence of end-stage renal disease (ESRD) morbidity and mortality is mounting. Kidney transplantation offers a good means of survival and improves longevity of patients with ESRD. However, not everyone is fortunate to benefit from this lifesaving renal replacement therapy due to the lack of available kidneys, one of the many reasons. It eventually expands the number of patients on waiting list of kidney transplantation. At present, deceased and living-related kidney donor transplantation models are widely used, but with limited success to keep up with the pace of burgeoning ESRD. A debate over the ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Hamid RB, Khan MT Tags: Saudi J Kidney Dis Transpl Source Type: research

Changing epidemiology of acute kidney injury in pregnancy: A journey of four decades from a developing country.
Abstract The incidence of acute kidney injury in pregnancy (P-AKI) has markedly decreased over the last three decades in India, particularly due to decreased incidence of postabortion AKI. However, P-AKI still accounts for 3%-5% of cases of total AKI. Postabortion sepsis has decreased to between 0.9% and 1.5% in 2014 from 9.4% in 1980-1990 in the new millennium. Currently, in India, majority of P-AKI (70%-90%) occurs in the postpartum period and in late 3rd trimester similar to the developed countries, but causes are different. We observed that preeclampsia/eclampsia is the most common cause of P-AKI in the late 3...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Prakash J, Prakash S, Ganiger VC Tags: Saudi J Kidney Dis Transpl Source Type: research

Associated factors of dialysis-dependence among acute kidney injury patients in intensive care unit.
Abstract Acute kidney injury (AKI) is a common problem in hospitals and many end up requiring dialysis. The aim was to identify the associated factors of dialysis-dependent of AKI patients admitted to the intensive care units (ICUs). A retrospective cohort study was conducted where a list of 121 AKI patients admitted to ICU in Hospital Universiti Sains Malaysia was retrospectively reviewed. AKI patients aged below 18 years old, had kidney transplantation or chronic dialysis before ICU admission and had incomplete medical record were excluded from the study. Simple and multiple logistic regression analysis were use...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Kamaruddin M, Hamid SA, Adnan AS, Naing NN, Wan Adnan WN Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and outcome of systemic fungal infections in renal transplant recipients - A tertiary care experience.
Abstract Fungal infections are an important cause of morbidity and mortality in renal transplant recipients. These infections account for 5% of all infections in renal transplant recipients. The symptoms of systemic fungal infections are nonspecific, particularly in their early stages, and this can lead to delay in diagnosis. Retrospective analysis was conducted on all renal transplants that were performed at our center over a 20-year period from 1996-2016. Cases of invasive fungal infections (IFIs) that occurred among renal transplant recipients were identified to describe the epidmeiology of these infections. A ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Shekar M, Elumalai R, Elayaperumal I, Yelahanka RP, Anandkumar DG, Bandi VK, Matcha J Tags: Saudi J Kidney Dis Transpl Source Type: research

Pattern of biopsy-proven kidney diseases: experience of a teaching hospital in Bahawalpur, Pakistan.
In conclusion, primary glomerular diseases were the predominant biopsy-proven kidney diseases, and FSGS and MN were the most common glomerular diseases. This pattern in South Punjab closely resembles that in southern and northern parts of the country. PMID: 31696854 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Malik SI, Idrees MK, Naseem K, Sadiq S, Raza SH, Ahmad FU Tags: Saudi J Kidney Dis Transpl Source Type: research

Profile of renal diseases in North-East Indian children.
Abstract The pattern of kidney diseases varies in different places due to differences in genetic status, socioeconomic status, access to health care, and presence of background infection. In spite of nephrology as a specialty since 1970s, there are still limited data regarding the spectrum of renal diseases in India. Our study was conducted in a tertiary care institute and referral center in northeast India. It provides insight into profile of renal diseases in hospitalized children. It is a cross-sectional study conducted in a government medical college in Assam. All children who were admitted in this department ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Sonowal R Tags: Saudi J Kidney Dis Transpl Source Type: research

Membranous nephropathy in a child with crescentic glomerulonephritis: Coincidence or comorbidity?
Abstract Rapidly progressive glomerulonephritis (RPGN) is rare syndrome in children, characterized by clinical features of glomerulonephritis and rapid loss of renal function, and is associated with crescentic glomerulonephritis. Primary membranous nephropathy (MN) is an immune-complex-mediated cause of the adult nephrotic syndrome but occurs less frequently in children. RPGN is rarely observed in adults with primary MN. In this article, we report a case of MN, which developed during long-term follow-up of previously treated RPGN. Our case may be the first to demonstrate primary MN and crescentic glomerulonephriti...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Girisgen I, Conkar S, Bulut İK, Şen S, Mir S Tags: Saudi J Kidney Dis Transpl Source Type: research

Monoclonal gammopathy of renal significance with light-chain deposition disease in kidney transplantation.
We report a case of LCDD with monoclonal gammopathy of renal significance diagnosed in the post-transplant period in a 28-year-old male and we discuss the diagnostic and therapeutic challenges in the clinical course. PMID: 31696857 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Aoudia R, Bacha MM, Ounissi M, Gaied H, Jerbi M, Abderrahim E, Abdallah TB, Goucha R Tags: Saudi J Kidney Dis Transpl Source Type: research

A case of advanced chronic kidney disease with severe hypocalcemia, how to safely manage and dialyze?
Abstract Patients often present with advanced chronic kidney disease (CKD) complicated with severe hypocalcemia that may be accompanied by electrocardiographic changes. The management of this kind of patients may require hemodialysis (HD). However, initiation of renal replacement therapy in this scenario needs special attention to avoid complications such as cardiac arrhythmias. A 22-year-old male presented to our emergency department with severe renal failure, hypocalcemia, hyperphosphatemia, severe acidosis, and QT prolongation on electrocardiography. The patient was kept in the emergency department under cardia...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Al-Shebani T, Azeem M, Elhassan EA Tags: Saudi J Kidney Dis Transpl Source Type: research

Congenital factor VII deficiency presenting first time as isolated recurrent hematuria at late age.
We report a case of a 23-year-old male, who presented to us with recurrent episodes of painless hematuria for the past three months due to congenital factor VII deficiency. PMID: 31696859 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Sethi S, Mehta S, Sethi N, Makkar V, Kaur S, Jhingar MK Tags: Saudi J Kidney Dis Transpl Source Type: research

An unusual clinical presentation of tuberculous pyomyositis in a renal allograft recipient.
We present a renal allograft recipient with pulmonary tuberculosis presenting with multiple subcutaneous abscesses involving left forearm, left thigh, suture site and left loin, which on later evaluation revealed to be due to Mycobacterium tuberculosis. PMID: 31696860 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Khandalvalli P, Nazneen S, Yadla M Tags: Saudi J Kidney Dis Transpl Source Type: research

Cryptococcosis masquerading as disseminated tuberculosis in a patient on chronic hemodialysis.
Abstract Chronic hemodialysis (HD) recipients are nearly ten times more prone to fungal infections compared to the general population. However, infections such as cryptococcosis usually affect immunocompromised patients, unusual in otherwise immunocompetent patients. Here, we describe a unique case of cryptococcosis in a human immunodeficiency virus negative end-stage renal disease (ESRD) patient. A 26-year-old female patient, diagnosed with ESRD, on maintenance HD for the past six months, presented with pyrexia of unknown origin associated with cervical lymphadenopathy, biopsy of which showed granulomatous inflam...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Meena P, Gupta A, Gaur L, Shingada A, Gupta P, Bhargava V, Rana DS Tags: Saudi J Kidney Dis Transpl Source Type: research

Severe hepatotoxicity of ritonavir, ombitasvir, paritaprevir, and dasabuvir in a kidney transplant recipient.
PMID: 31696862 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Bukal N, Furic-Cunko V, Juric I, Katalinic L, Dedo A, Basic-Jukic N Tags: Saudi J Kidney Dis Transpl Source Type: research

Hemodialysis tunneled catheter-related infection in a tertiary care center: A changing trend.
PMID: 31696863 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2019 Category: Urology & Nephrology Authors: Pattanashetti N, Ramachandran R, Kohli HS, Gupta KL Tags: Saudi J Kidney Dis Transpl Source Type: research

The Relationship between carotid artery calcification and pulp stone among hemodialysis patients: A retrospective study.
Abstract The aim of this study was to determine the relationship between the presence of carotid artery calcification (CAC) and pulp stone (PS). A total of 60 chronic hemodialysis (HD) patients (30 CAC positive, 30 CAC negative) participated in this study. The mean age of patients was 54.7 ± 16.4 years, and 32 (53%) of them were male. CAC was defined as the presence of heterogeneous nodular opacities in the soft tissue in C3-C4 intervertebral area. Panoramic radiographs of the patients were evaluated for CAC and PS by two oral and maxillofacial radiologists. PS was evaluated in all healthy, decayed, and res...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Yilmaz SG, Yilmaz F, Bayrakdar IS, Harorli A Tags: Saudi J Kidney Dis Transpl Source Type: research

Adequacy of infective endocarditis prophylaxis before dental procedures among solid organ transplant recipients.
In this study, we aimed to investigate the IE prophylaxis in general dental and periodontal surgical procedures among our SOT recipients. Medical records of 191 SOT recipients (32 liver transplant recipients, 54 heart transplant recipients, and 105 kidney transplant recipients) who were admitted to our hospital between January 2016 and January 2018 were evaluated. A total of 65 patients who underwent dental procedures were included in the study. We investigated the adequacy of IE prophylaxis according to the current guidelines. Two groups were created according to whether they received antibiotic prophylaxis or not. The me...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Karacaglar E, Akgun A, Ciftci O, Altiparmak N, Muderrisoglu H, Haberal M Tags: Saudi J Kidney Dis Transpl Source Type: research

High Serum Endothelin-1 Level is Associated with Poor Response to Steroid Therapy in Childhood-Onset Nephrotic Syndrome.
This study aims to investigate the relationship between ET1 serum level and the response to steroid therapy in children with primary NS. Serum ET1 levels were evaluated in 55 children with NS. They were classified into two groups: 30 patients with steroid-sensitive NS (SSNS) and 25 patients with steroid-resistant NS (SRNS). The SSNS group was further divided into infrequent-relapsing NS (IFRNS) and steroid-dependent NS (SDNS), while the SRNS group was subdivided into two groups according to renal pathology. ET1 levels were significantly higher in the SRNS group (52.5 ± 45.8 pg/dL) compared to the SSNS group (18.3 ± 17 pg/dL) (P
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Ahmed HM, Morgan DS, Doudar NA, Naguib MS Tags: Saudi J Kidney Dis Transpl Source Type: research

Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis: A single-center experience.
This study aimed to describe the early and late effect of TPE in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) presented with acute kidney injury (AKI). Retrospective study comprised patients with SLE and AAV with AKI seen between January 2000 and June 2014 at King Faisal Specialist Hospital and Research Center in Riyadh. All patients underwent TPE. Retrospectively, all patients were assessed for early and late renal outcome at 12- month and 24-month intervals. Renal outcome was assessed according to serum creatinine level, glomerular filtration rate, a...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Al Hamzi HA, Al-Mayouf SM, Al Shaikh AA, Al-Sheikh HA, Alshomar AA, Al Humaidan HA, Al Dalaan AN, Al Saleh SS Tags: Saudi J Kidney Dis Transpl Source Type: research

Vitamin D status of children with moderate to severe chronic Kidney Disease at a Tertiary Pediatric Center in Cape Town.
The objective of our study is to determine the prevalence of Vitamin D deficiency in children with CKD stages three to five and those receiving chronic dialysis, to ascertain whether there is a relationship between Vitamin D deficiency and the stage of CKD, and to identify any clinical correlates associated with the Vitamin D status. A single-center, retrospective review was conducted of 46 children (younger than 18 years) with CKD stages 3-5D who attended the renal clinic of the Red Cross Children's Hospital between October 2013 and November 2014. In total, 73.9% of the study population had suboptimal Vitamin D levels (43...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Solarin AU, Nourse P, Gajjar P Tags: Saudi J Kidney Dis Transpl Source Type: research

Chronic Kidney Disease among Middle-Aged and Elderly Population: A cross-sectional screening in a Hospital Camp in Varanasi, India.
This study aims to estimate the prevalence of CKD and patterns of known risk factors among the general population (middle-aged and elderly) attending a screening camp in a community-based setting. The study participants constituted a part of the general population of Varanasi (aged ≥45 years) who volunteered in a screening camp that was organized as part of the World Kidney Day Initiative at Opal Hospital. Information on age, sex, height, weight, smoking and drug history, history of diabetes, hypertension, and family history of kidney disease was extensively interrogated, while laboratory investigations such as urinalys...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Rai PK, Rai P, Bhat RG, Bedi S Tags: Saudi J Kidney Dis Transpl Source Type: research

Spectrum of glomerulonephritis in Egyptian patients with rheumatoid arthritis: A University Hospital experience.
Abstract Rheumatoid arthritis (RA) is accompanied by a variety of nephropathies. It is often difficult to distinguish between disease-associated and drug-associated renal diseases. Three hundred and seventy-six RA patients with renal involvement were included in our study; they were subjected to full history and clinical examination, kidney function, 24-h urinary protein, and kidney biopsy. All our patients were on methotrexate, low dose steroids, and nonsteroidal anti-inflammatory drugs, in addition to the previous medications. About 79.3%, 20.7%, 6.9%, and 5.9% of our patients were on leflunomide, hydroxychloroq...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Fayed A, Shaker A, Hamza WM, Wadie M Tags: Saudi J Kidney Dis Transpl Source Type: research

Quality of Life in Chronic Kidney disease children using assessment Pediatric Quality Of Life Inventory ™.
Quality of Life in Chronic Kidney disease children using assessment Pediatric Quality Of Life Inventory™. Saudi J Kidney Dis Transpl. 2019 Jul-Aug;30(4):812-818 Authors: Pardede SO, Rafli A, Gunardi H Abstract Chronic kidney disease (CKD) is still a serious health problem in children with increasing morbidity and affecting children's quality of life (QoL). The prevalence of children with CKD worldwide is approximately 82 cases/year/1 million children. From the Indonesian Basic Health Survey 2013, the prevalence of patients with CKD aged ≥15 years in Indonesia was 0.2%. To assess the QoL in ch...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Pardede SO, Rafli A, Gunardi H Tags: Saudi J Kidney Dis Transpl Source Type: research

Calcification of abdominal aorta in patients recently starting hemodialysis: A single-center experience from Egypt.
Abstract Vascular calcification (VC) is a well-known complication in patients with chronic kidney disease (CKD). Keeping in mind, the end goal to assess the genuine effect of mineral bone disease in the pathogenesis of blood vessel calcification during the pre-dialysis course of CKD, we assessed the prevalence and extent of abdominal aortic calcification (AAC) in nondiabetic CKD patients recently starting hemodialysis (HD). Eighty-one patients with end-stage renal disease beginning HD over a one-month period were selected. They underwent a detailed clinical examination and laboratory evaluation, including serum ca...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Fayed A, Elnokeety MM, Attia K, Sharaf El Din UA Tags: Saudi J Kidney Dis Transpl Source Type: research

Significance of paraprotein gap and β2 microglobulins in predialysis Population with multiple myeloma.
Significance of paraprotein gap and β2 microglobulins in predialysis Population with multiple myeloma. Saudi J Kidney Dis Transpl. 2019 Jul-Aug;30(4):825-831 Authors: Ali H, Kishore B, Baharani J Abstract Paraprotein gap is sometimes used as a screening tool in some autoimmune diseases, cancers, and screening for latent infections. The increase in the paraprotein gap in these diseases was hypothesized to be the result of increased levels of immunoglobulins, raising the total serum protein without any changes in serum albumin. Our aim was to assess the overall survival using novel chemotherapy, bo...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Ali H, Kishore B, Baharani J Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and correlates of microalbuminuria in Yemeni children with sickle cell disease.
Abstract Microalbuminuria (MA) has been recognized as a sensitive marker of early glomerular injury and a predictor of kidney dysfunction in patients with sickle cell disease (SCD). Limited data are available about MA in SCD children in the Arab countries and none from Yemen. The aim of this study is to determine the prevalence and correlates of MA among 101 children aged 1-16 years, with SCD at their steady state. Children were recruited during their routine health-care visits to the pediatric outpatient clinic in Al-Sadaqa general teaching hospital, Aden, Yemen, between September 2014 and February 2015. A random...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Al-Musawa FE, Al-Saqladi AM Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and Pattern of Human Immunodeficiency Virus-Associated Nephropathy among Human Immunodeficiency Virus-Positive Children at the University of Maiduguri Teaching Hospital, Nigeria.
Abstract The kidney is an important target organ in human immunodeficiency virus (HIV) infection, and a variety of renal disorders could occur throughout the course of the disease. HIV- associated nephropathy (HIVAN) is the most common form of kidney disease resulting directly from HIV infection. The true prevalence of HIVAN among infected African children is unknown largely due to lack of surveillance and reporting. We thus aimed to determine the prevalence of HIVAN and associated factors among HIV-infected children at the University of Maiduguri Teaching Hospital. This was a cross-sectional study carried out at ...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Ibrahim HU, Elechi HA, Rabasa AI, Ashir GM, Farouk AG, Yauba MS, Ibrahim BA Tags: Saudi J Kidney Dis Transpl Source Type: research

Bone mineral density and vitamin D status in children with remission phase of steroid-sensitive nephrotic syndrome.
This study included 32 patients with SSNS who had not received GC treatment in the last 6 months and a control group of 20 healthy children. Serum levels of calcium, phosphate, alkaline phosphatase, 25-(OH)D, and parathyroid hormone (PTH) were measured. BMD was determined in the lumbar spinal region using dual-energy X-ray absorptiometry (DEXA). Serum 25-(OH)D levels were lower in the SSNS patients than in the healthy children (P
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Cetin N, Gencler A, Sivrikoz IA Tags: Saudi J Kidney Dis Transpl Source Type: research

Predictive values of dyslipidemia and B-type natriuretic peptide levels in juvenile systemic lupus erythematosus: A two center-experience.
This study revealed that BNP levels were increased in SLE patients without cardiac symptoms as compared to healthy controls; furthermore, the BNP levels were higher in active SLE patients with HF. The data indicated that there is a high risk for CVD in SLE with high disease activity, as demonstrated by the higher frequency of dyslipidemia and higher BNP concentrations than in healthy controls. PMID: 31464243 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: El-Gamasy MA, Abd Elsalam MM, Abd-El Latif AM, Elsaid HH Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and risk factors of hypertension following nephrectomy in living kidney donors.
Abstract Living donor kidney transplantation is the treatment of choice for the patients with end-stage renal disease, especially where deceased donor programs are limited. There are limited data on the outcomes of living kidney donors (LKD) from developing countries, especially from North Africa. The aim of this study is to evaluate the prevalence of hypertension (HTN) in LKD and to analyze its risk factors. This is a longitudinal monocentric study, and the donors who underwent nephrectomy for donation between 2006 and 2015 were included. Ninety-two donors were assessed. The mean age at the time of nephrectomy wa...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Abdellaoui I, Sahtout W, Awatef A, Zallama D, Achour A Tags: Saudi J Kidney Dis Transpl Source Type: research

Scrub typhus-associated acute kidney injury: A study from a South Indian Tertiary Care Hospital.
Abstract Infections including scrub typhus contribute to a significant proportion of community-acquired acute kidney injury (AKI) in the tropics. Scrub typhus infection now requires global attention since disease outbreaks are being reported across continents. We intended to study the clinical profile, renal involvement, and parameters predicting renal involvement in scrub typhus infection. This is a retrospective study. The medical records of all patients who were admitted and treated for scrub typhus infection for a study period of two years (from September 2015 to August 2017) were analyzed, and salient clinica...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Jayaprakash V, Vamsikrishna M, Indhumathi E, Jayakumar M Tags: Saudi J Kidney Dis Transpl Source Type: research

Correlation between central arterial stiffness and handgrip strength in chronic hemodialysis patients.
This study aimed to find the correlation between central arterial stiffness and handgrip strength (HGS). We conducted a cross-sectional study at the Dialysis Unit of Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from April to May 2018. The recruited participants were aged between 18 and 60 years and underwent dialysis twice a week for over three months. Examination of central arterial stiffness and HGS was done by SphygmoCor® and Jamar® dynamometer, respectively. The obtained data were analyzed with bivariate correlation and partial correlation to confounding factors. The participants of thi...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Yunita Sari CM, Suhardjono, Nainggolan G, H Marbun MB, Abdullah M Tags: Saudi J Kidney Dis Transpl Source Type: research

Serum tumor markers in advanced stages of chronic kidney diseases.
Abstract Chronic kidney disease (CKD) is one of the most important noncommunicable diseases. Abnormal concentration of some tumor markers were found in a spectrum of nonmalignant diseases such as benign ovarian tumors, breast diseases, chronic hepatitis, cirrhosis, diseases of the bile duct, and in CKD. Hence, the present study was undertaken to evaluate carbohydrate antigen (CA) 15-3, carcinoembryonic antigen (CEA), CA 19-9, and human chorionic gonadotropin (HCG) concentrations in advanced stages of CKD (Stage 4 and 5) patients who are not on dialysis and with no known malignancy. Patients included 40 CKD patient...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Rani BS, Suchitra MM, Srinivasa Rao PVLN, Kumar VS Tags: Saudi J Kidney Dis Transpl Source Type: research

Attitudes and perceived barriers toward arteriovenous fistula creation and use in hemodialysis patients in Jordan.
In conclusion, in this sample population from HD patients in Jordan, majority would recommend an AVF as mode of access. Perceived barriers include lack of timely referral for vascular surgical evaluation and poor understanding of disease. A systematic assessment of the process that precedes the creation of AVF, with focus on areas of reported barriers may allow for better utilization of AVF. PMID: 31464248 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Hamadah AM Tags: Saudi J Kidney Dis Transpl Source Type: research

Usefulness of ambulatory blood pressure monitoring in chronic kidney disease: The moroccan experience.
Abstract Among patients with chronic kidney disease (CKD), hypertension (HTN) is very common and widely recognized to accelerate the progression of CKD and increase the risk for cardiovascular events. Accumulated data indicate that ambulatory blood pressure monitoring (ABPM) is better in detecting HTN than office blood pressure (BP) measurement. The goal of this study is to describe the ABPM characteristics in a group of CKD and hypertensive patients. A transversal study was conducted over a period of six months, to evaluate the ABPM patterns among a group of hypertensive patients with CKD (Group 1) and compared t...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Asserraji M, Bouzerda A, Soukrate S, Maoujoud O, Belarbi M, Zemraoui N, Bendriss L, Khatouri A Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal Cortical Necrosis; Five Consecutive Cases within Short Span of Time.
Abstract Renal cortical necrosis (RCN) is characterized by patchy or diffuse destruction of all the elements of renal cortex resulting from significantly diminished renal arterial perfusion due to vascular spasm and microvascular injury. It is a rare cause of acute kidney injury (AKI) in developed countries with frequency of 1.9%-2% of all patients of AKI. In contrast, the incidence of RCN is higher in developing countries ranging from 6%-7%. Obstetric complication is the main cause of RCN, earlier it was about 20%-30% which has been declining to 5% in the Indian subcontinent during the past two decades. The aim o...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Jaynul Islam SM, Akhter S, Hossain MS Tags: Saudi J Kidney Dis Transpl Source Type: research

Actual diet and nutritional deficiencies status in children on peritoneal dialysis at the Vietnam National Hospital of Pediatrics.
Abstract Nutrition is essential for children with end-stage renal disease, especially for those suffering from peritoneal dialysis (PD). Although the number of PD children has increased annually at the Vietnam National Hospital of Pediatrics, studies about the diet and nutritional deficiencies status of PD children is still limited. The aim of this study was to describe the actual diet and status of nutritional deficiencies of PD patients. This cross-sectional study was conducted on 31 PD children aged 2-15 years old using the 24-h dietary recall and biochemical parameters in blood (albumin, hemoglobin, calcium, s...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: My Thuc LT, Dung NQ, Ha VN, Tam ND, Hang Nga NT Tags: Saudi J Kidney Dis Transpl Source Type: research

Etiological spectrum of anemia in non-dialysis-dependent chronic kidney disease: A single-center study from India.
Abstract A retrospective study was conducted over seven years and it aimed to find out various causes of anemia among patients with chronic kidney disease (CKD). The study included nondialysis-dependent adult CKD patients who underwent anemia evaluation. A total of 584 patients were studied. Three hundred and twenty-one (55%) patients were male and 263 (45%) were female. The mean age of the patients was 55.5 ± 14 years. One hundred and seventy-eight (30.5%) had a diabetic CKD and 406 (69.5%) had a nondiabetic CKD. Seventy-two (12.3%) patients were in CKD Stage 3, 193 (33%) patients in CKD Stage 4, and 319 (...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Vikrant S Tags: Saudi J Kidney Dis Transpl Source Type: research

Legal policies of organ transplantation in India: Basics and beyond.
Abstract The Organ Transplantation Act issued by the Government of India 1994 has undergone major and minor changes in the form of addition of rules and amendments in order to improve the Act to make it much acceptable legally. Over a period of time, with an increase in cadaver organ donations, the rules and policies with regard to the same have been defined and redefined over the years. In this article, the Act, the rules, the amendments, the quick essentials of approach, and the forms are reviewed. PMID: 31464253 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Yadla M Tags: Saudi J Kidney Dis Transpl Source Type: research

A "double-seropositive" Vasculitis for antiglomerular basement membrane antibodies and antineutrophil cytoplasmic antibody, and multiple myeloma, all three with simultaneous diagnosis of renal involvement, common pathophysiology, or pure coincidence? first case in the World.
We report probably the first case of double-seropositive vasculitis for antiglomerular basement membrane (GBM) antibodies and ANCA associated with MM with renal involvement. A 60- year-old-female presented with severe acute kidney injury. Three months earlier, she had a history of bone pain. Blood workup found a creatinine of 1100 μmol/L and a C-reactive protein of 60 mg/L. Anti-GBM antibodies returned positive at 400 U/mL and pANCA positive at 380 U/mL. Plasma protein immunofixation found a monoclonal immunoglobulin G (IgG) KAPPA peak; the myelogram found a 10% plasmocytosis. On the day 4 of hospitalization, the patien...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Chettati M, Adnouni A, Bouchemla N, Anibar S, Fadili W, Laouad I Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury due to acute cortical necrosis following vivax malaria.
Abstract Malaria is a parasitic infection of global importance but has a high prevalence in the developing countries. Renal failure is a common complication of severe Plasmodium falciparum malaria and has been reported in up to 40% of all cases. Acute kidney injury (AKI), however, is not commonly associated with Plasmodium vivax infection. In those patients who develop AKI following P. vivax infection, the cause is commonly attributed to mixed undiagnosed falciparum infection or coexistent sepsis, dehydration, or hypotension. Infrequently, an association of P. vivax infection with thrombotic microangiopathy (TMA) ...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Nair RK, Rao KA, Mukherjee D, Datt B, Sharma S, Prakash S Tags: Saudi J Kidney Dis Transpl Source Type: research

Identification of a new homozygous CEP290 gene mutation in a Saudi Family causing joubert syndrome using next-generation sequencing.
Abstract A 19-year-old female with a learning difficulty, ataxia, and nystagmus was referred to our clinic with advanced chronic kidney disease. Her renal biopsy revealed features of nephronophthisis (NPHP). Magnetic resonance imaging of the brain showed "molar tooth sign." The clinical picture was consistent with Joubert syndrome (JS). Two of her siblings were subsequently found to have a similar condition. Genomic material from the patient, her twin sister, and later on from parents was analyzed for deletion/duplication mutations in the NPHP1 gene using multiplex ligation-dependent probe amplification....
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Abdelgadir E, Al Sahlawi M, Al Turki L, Khamees K, Ahmed W Tags: Saudi J Kidney Dis Transpl Source Type: research

A rare association of pathological variant of Alport's syndrome caused by hemizygous 5' splice mutation in intron 10 of COL4A5 gene with metachondromatosis due to heterozygous missense variation in protein tyrosine phosphatase nonreceptor type 11 gene.
We report a rare case of a 24-year-old male with Alport's syndrome with metachondromatosis due to missense variation in PTPN11 gene. PMID: 31464257 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Sethi S, Mehta S, Makkar V, Kaur S, Sohal PM Tags: Saudi J Kidney Dis Transpl Source Type: research

Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma.
We describe a case of bronchiolitis obliterans organizing pneumonia (BOOP) due to thalidomide. A 51-year-old man with IgG lambda myeloma was treated with thalidomide and dexamethasone. Seven days after the beginning of chemotherapy, the patient presented a fever and a persistent cough. Auscultation revealed crackles in both pulmonary bases. The chest X-ray showed a diffuse bilateral alveolar-interstitial syndrome. Computed tomography scan revealed bilateral pulmonary involvement, with bilateral interstitial alveolar infiltration and ground-glass pattern consolidations. Pulmonary infection, malignant tumor, and lung involve...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: El Ati Z, Lamia R, Cherif J, Jbali H, Fatma LB, Mami I, Khedher R, Smaoui W, Krid M, Hamida FB, Beji S, Zouaghi MK Tags: Saudi J Kidney Dis Transpl Source Type: research

Cyclophosphamide-induced melanonychia in a patient with steroid dependent nephrotic syndrome: A rare presentation.
We report a 38-year-old female, a known case of steroid dependent nephrotic syndrome, who developed melanonychia on starting treatment with cyclophosphamide. It is a benign condition, which resolves on discontinuation of the drug. PMID: 31464259 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Mehta S, Makkar V, Soha PM, Sethi S, Kaur S Tags: Saudi J Kidney Dis Transpl Source Type: research

Ruptured intracranial aneurysm and recessive polycystic kidney Disease: A Rare Association.
We describe a rare case of a 29-year-old man with ARPKD presenting with subarachnoid hemorrhage secondary to a ruptured intracranial aneurysm. The diagnosis of ARPKD was at the age of eight years based on typical ultrasonography findings with polycystic kidneys and liver disease. Magnetic resonance cholangiography showed a nonobstructive dilatation of intrahepatic bile ducts. Liver biopsy showed hepatic fibrosis. None of the family members was affected. At the age of 15 years, he had progressed to end-stage kidney disease, and hemodialysis was started. The patient had always a severe arterial hypertension. At the age of 29...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Helal I, Handous I, Khadhar M, Bezzine H, Hamida FB, Abdallah TB Tags: Saudi J Kidney Dis Transpl Source Type: research

Cramps during Hemodialysis: Are They Always Innocent?
We present a male HD patient with cramps during his session, attributed to acute limb ischemia due to thrombosis of a common femoral artery aneurysm (CFAA). The true CFAAs are extremely rare, but the pseudoaneurysms (or false aneurysms) are less uncommon resulting after femoral catheterization for diagnostic and therapeutic procedures. This aneurysm was eccentric in shape which in conjunction with the patient's history of femoral catheterization strongly suggests us to consider it a pseudoaneurysm. Although the patient was operated with the clinical suspicion of arterial embolism due to atrial fibrillation and the subthera...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Dousdampanis P, Trigka K, Ntouvas I, Assimakopoulos SF, Musso CG, Papadoulas S Tags: Saudi J Kidney Dis Transpl Source Type: research

Everolimus worsening chronic proteinuria in patient with diabetic nephropathy post liver transplantation.
We report a 73-year old male with diabetic glomerulosclerosis, acute liver failure due to Budd-Chiari syndrome, chronic low platelets, and worsening proteinuria from 0.46 g protein/g creatinine to 2.2 g protein/g creatinine. Workup revealed no thrombotic microangiopathy through skin biopsy, and a renal biopsy confirmed only clinically suspected diabetic and hypertensive glomerulosclerosis and possible calcineurin inhibitors. On discontinuation of everolimus urine protein decreased back to 0.6 g/g creatinine. We review the mechanism of mTOR-induced proteinuria and how this may affect diabetic nephropathy secondarily. We als...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2019 Category: Urology & Nephrology Authors: Hanna RM, Yanny B, Arman F, Barsoum M, Mikhail M, Al Baghdadi M, Rastogi A, Wallace W, Saab S Tags: Saudi J Kidney Dis Transpl Source Type: research