A nursing perspective of caring for patients with end-stage renal disease in hospitals.
This article hereby addresses the various steps in developing such a role as facilitating nurses to work to their full professional and academic potential ensures best practice. PMID: 30152410 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Garvey TM, McCarron NM Tags: Saudi J Kidney Dis Transpl Source Type: research

The integrated care pathway of nephrology and dental teams to manage complex renal and postkidney transplant patients in dentistry: A holistic approach.
Abstract The number of patients with chronic kidney disease (CKD) is increasing worldwide. Different studies have shown that patients with CKD have poorer oral health status and they require a high amount of dental treatments than the general population. Therefore, it is crucial for dental care providers to have basic knowledge about kidney function and its implications for oral health and dental treatments. It is also essential to stress to nephrologists the importance of referring patients who are at a late stage of CKD to a specialty center for dental assessment before starting renal replacement therapy (i.e., ...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Abed H, Burke M, Shaheen F Tags: Saudi J Kidney Dis Transpl Source Type: research

Chronic kidney disease in children: Using novel biomarkers as predictors of disease.
Abstract Chronic kidney disease (CKD) in children contributes to the global health burden. The focus on using novel biomarkers to predict the onset and progression of the disease has increased tremendously over the past decade. Discovery of these biomarkers offers prospects for the early anticipation of the late stages of CKD, slowing down disease progression, and achieving better disease outcomes. The aim of this article is to classify and highlight the utility of these novel biomarkers in predicting disease-onset and progression. Biomarkers of CKD are broadly classified into biomarkers of kidney function and bio...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Uwaezuoke SN, Ayuk AC, Muoneke VU, Mbanefo NR Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of endothelial progenitor cell (CD34) as a marker of cardiovascular risk in children on regular hemodialysis.
Abstract Endothelial progenitor cells (EPCs) CD34 are bone marrow-derived cells that decrease in chronic kidney disease (CKD) patients especially when they reach end-stage renal disease and may be a risk marker of cardiovascular (CV) diseases. The aim of our study is to investigate the endothelial progenitor cell CD 34 numbers in children with CKD on regular hemodialysis (HD) and detect their association with vascular stiffness. We recruited 25 children on regular HD, who were selected from the HD unit of Al-Zahraa Hospital, Al-Azhar University. Another group of 25 age and sex matched healthy children served as as...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Abdel-Salam M, Abd Elsalam R, Youssef N, Mamdouh F, Abdel-Salam T Tags: Saudi J Kidney Dis Transpl Source Type: research

The prevalence of APOL1 gene variants in a cohort of renal disease patients in Western Saudi Arabia.
Abstract Two variants for APOL1; the gastrointestinal (G1) variant (S342G and 1384M substitutions) and the G2 variant (N388 and Y389 deletions) have been previously described to be associated with renal disease. The prevalence of APOL1 variants in Saudi Arabia is unknown. We aimed to determine the prevalence of APOL1 variants in a cohort of patients with renal disease in Saudi Arabia. Patients with renal disease followed up at King Abdulaziz University Hospital were approached consecutively at the out patient clinic, and unaffected controls were approached at the blood donation area. Clinical and laboratory data w...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Adam S, Badawi M, Zaher G, Alshehri B, Basaeed A, Jelani M, Kashqari A Tags: Saudi J Kidney Dis Transpl Source Type: research

Impact of pharmaceutical care on clinical outcomes among hemodialysis patients: A multicenter randomized controlled study.
Abstract The aim of this study is to assess the impact of pharmaceutical care on medication adherence, hemoglobin (Hb) levels, blood pressure (BP), and interdialytic weight gain (IDW) among hemodialysis (HD) patients. An open-label randomized controlled study has been conducted at three different hospitals of HD centers. The patients have been randomized into two groups [usual care group (UCG) and pharmaceutical care group (PCG)] by block design. The assessment has been carried out at baseline, 6th, and 12th months. At the end of the study, a total number of 153 patients have been followed. Out of 153 patients, 83...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Mateti UV, Nagappa AN, Attur RP, Nagaraju SP, Rangaswamy D Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of the relationship between muscle mass and serum myostatin levels in chronic hemodialysis patients.
Abstract The loss of muscle mass and cachexia is commonly seen in hemodialysis (HD) patients and contribute to morbidity and mortality. The exact mechanism of this fact is multifactorial and still unclear. Myostatin, a transforming growth factor-ß family ligand, is released from the skeletal and heart muscle and may be responsible for muscle degradation and atrophy. The aim of this study is evaluation of the relationship between muscle mass and serum myostatin level in chronic HD patients. One hundred and forty HD patients (79 males, 28 diabetic, mean age; 53.96 ± 13.6) were included in this cross-sec...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Koyun D, Nergizoglu G, Kir KM Tags: Saudi J Kidney Dis Transpl Source Type: research

Pediatric focal segmental glomerulosclerosis in Jordan: A tertiary hospital experience.
Abstract Our objective is to study the demographical data, clinical course and outcome of children with primary focal segmental glomerulosclerosis (FSGS) in Jordan. A retrospective chart review of patients with a diagnosis of FSGS at a tertiary care hospital from the period July 2010 to July 2016 was conducted. A total of 99 patients were analyzed. The mean age of presentation was 3.71 ± 2.59 years, 66% were male. At presentation, 66.6% of patients were steroid-resistant, 10% had a steroid dependant course and 20.2% had familial FSGS. Cyclosporine was used in 66.6% of children with a response rate of 46.9%....
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Almardini RI, Albaramki JH, Al-Saliata GM, Farah MQ, AlRabadi KH, Albderat JT Tags: Saudi J Kidney Dis Transpl Source Type: research

Predictors of coronary calcification in Indian hemodialysis patients.
Abstract Several biomolecules potentially serve as promoters or inhibitors of calcification in dialysis patients which include fetuin A, matrix gla protein, osteopontin, osteoprotegerin, etc. The primary aim was to compare the biomarkers of coronary artery calcification (CAC) and to study its role as predictors of CAC in hemodialysis (HD) patients. Of 126 patients undergoing chronic HD, 100 patients completed the study. Blood samples were drawn for serum creatinine, electrolytes, calcium, phosphorus, Vitamin D3, parathyroid hormone (PTH), lipid profile, high sensitivity C-reactive protein, ferritin, fetuin A, and ...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Jasani R, Hase N, Kumar R, Dedhia P, Jamale T, Bajpai D Tags: Saudi J Kidney Dis Transpl Source Type: research

Associations between phosphate binders prescription, illness perception, and depression in hemodialysis patients.
This study found a significant positive correlation between PBs daily dose frequency with consequence, timeline, and illness concern. Type of PBs used influenced personal control significantly. History of PBs side effects resulted in significantly lower treatment control and lower emotional representation. There was a significant negative relationship between dialysis vintage with both identity and IP score. Depressed patients had significantly higher emotional representation compared to healthy controls. Meanwhile, there was a positive correlation between BDI-II score with coherence, consequence, and emotional representat...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Mohamed Koya SNMV, Zulkepli NA Tags: Saudi J Kidney Dis Transpl Source Type: research

Characteristics and outcome of postpartum acute kidney injury requiring dialysis: A single-center experience from North India.
Abstract Postpartum acute kidney injury (AKI) is one of the serious complications of pregnancy and is associated with high mortality and morbidity. We conducted this study to determine the characteristics and outcome of the most severe form of postpartum AKI requiring dialysis. This prospective, observational study was conducted in Sawai Man Singh Medical College, Jaipur. All postpartum female suffering from AKI requiring dialysis between July 2014 and December 2016 were included in the study. Demographic, clinical and laboratory data of the patients were recorded. Outcome variables included survival at hospital d...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Tanwar RS, Agarwal D, Gupta RK, Rathore V, Beniwal P, Joshi P, Malhotra V Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence of subclinical hypothyroidism in patients with chronic kidney disease on maintenance hemodialysis.
Abstract The prevalence of subclinical hypothyroidism (SHT) has been reported to be much higher in patients with chronic kidney disease (CKD) than in the general population. SHT has been identified as a strong predictor of mortality and a risk factor for cardiovascular disease in CKD. The study aimed to provide local data on the prevalence of SHT in CKD patients on maintenance hemodialysis (MHD). A total of 72 patients with CKD on MHD were enrolled. Nonprobability consecutive sampling was performed on patients of either gender aged 14-50 years who met the inclusion and exclusion criteria. Thyroid-stimulating hormo...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Naseem F, Mannan A, Dhrolia MF, Imtiaz S, Qureshi R, Ahmed A Tags: Saudi J Kidney Dis Transpl Source Type: research

Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients, Egyptian multicenter experience.
This study was carried out on 120 pediatric patients admitted to PICUs of four university hospitals. They were divided into Group 1 included 60 patients meeting the criteria of AKI Network and septic shock, the second group included 60 critically ill patients without AKI or septic shock and the third group was 60 healthy children as controls. HSP60 levels were measured in the plasma using a commercially available ELISA and difference between groups were analyzed with a Kruskal-Wallis one-way ANOVA. P
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: El-Gamasy MA, El-Sadek AE, Fakhreldin AR, Kamel A, Elbehery EG Tags: Saudi J Kidney Dis Transpl Source Type: research

New-onset diabetes after transplantation among renal transplant recipients at a new transplant center; King Fahad Specialist Hospital-Dammam, Saudi Arabia.
Abstract New-onset diabetes after transplant (NODAT) has been reported to occur in 4%-25% of renal transplant recipients. Its development has also been shown to be associated with an adverse impact on patient survival and an increased risk of graft rejection and graft loss, as well as an increased incidence of infectious complications. The study aims to describe the incidence of NODAT and its important risk factors in a single center. We conducted a retrospective analysis of data from all kidney transplant recipients in our center, transplanted between September 2008 and May 2013. Out of 311 patients, 77 had diabe...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Abdulrahman MM, Idris MA, Elhakimi WF, Akhtar M, Hammam M, Aldajani AA, Aljamaan YM, Alshahri HM, Housawi A Tags: Saudi J Kidney Dis Transpl Source Type: research

The impact of blood flow rate on dialysis dose and phosphate removal in hemodialysis patients.
Abstract The inadequacy of dialysis and hyperphosphatemia are both associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. The aim of this study was to determine the effect of increasing BFR on dialysis dose and phosphate removal. Forty-four patients were included in a cross-sectional study. Each patient received six consecutive dialysis sessions as follows: three consecutive sessions with a BFR of 250 mL/min, followed by three others with BFR of 350 mL/min without changing the other dialysis pa...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Rafik H, Aatif T, El Kabbaj D Tags: Saudi J Kidney Dis Transpl Source Type: research

Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology.
Abstract Oxygen is very important to the existence of life. Oxygen deficiency, defined as hypoxia, elicits adaptive responses in cells and tissues. Lower oxygen concentration can cause the alteration of renal function, affects the maintenance of a balance of the body fluids, electrolytes, pH, and blood pressure homeostasis. Impaired fluid regulation could, in addition, contribute to the precipitation of pulmonary edema and exacerbate hypoxemia which may accelerate the progression of chronic kidney disease. In this context, the present study attempted to evaluate the association of renal injury and oxidative stress...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Samanta A, Patra A, Mandal S, Roy S, Das K, Kar S, Nandi DK Tags: Saudi J Kidney Dis Transpl Source Type: research

Hypervolemia and high tumor necrosis factor- α: An interesting finding during the first six months' posttransplant period in kidney transplant recipients with good renal function.
Hypervolemia and high tumor necrosis factor-α: An interesting finding during the first six months' posttransplant period in kidney transplant recipients with good renal function. Saudi J Kidney Dis Transpl. 2018 Jul-Aug;29(4):889-892 Authors: Paydas S, Karaer R, Centiner S Abstract Renal transplantation is the treatment of choice for the end-stage renal disease. Hypervolemia and inflammation are commonly overlooked. We investigated whether hyper-volemia develops in kidney transplant recipients with estimated glomerular filtration rate (eGFR)>70 mL/min and if there is there any correlation bet...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Paydas S, Karaer R, Centiner S Tags: Saudi J Kidney Dis Transpl Source Type: research

Study of glucocorticoid receptors in T lymphocytes (CD3/GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome.
Abstract Little was known about the relationships between the T lymphocytes (CD3+), expression of glucocorticoid receptors (GCR) and the response to GC treatment in children with the idiopathic nephrotic syndrome (INS). Our objective was to determine the relation between steroid responsiveness and GCR expression in T lymphocytes. The present study was carried out on 80 children with new-onset INS admitted in Pediatric Nephrology Units of Zagazig and Tanta University Hospitals and on 40 healthy children of the same age and sex who served as control group. The Subjects were subdivided into three groups as follows: G...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Amin EK, El-Gamasy MA, Shokry DM, Khalifa NA Tags: Saudi J Kidney Dis Transpl Source Type: research

Effectiveness of intradialytic exercise on dialysis adequacy, physiological parameters, biochemical markers and quality of life - A pilot study.
This study aimed to determine the effectiveness of intradialytic exercise on dialysis efficacy, physiological parameters, biochemical markers, and quality of life among patients on HD. Experimental research design was adopted to conduct the study with 20 patients in our HD unit who met the inclusion criteria and patients were randomly allocated into experimental group and control group. The experimental group received intradialytic exercise during the first 2 h of HD besides receiving routine care compared to the control group. Data were tabulated and analyzed using the SPSS package. The finding of the present pilot study ...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Paluchamy T, Vaidyanathan R Tags: Saudi J Kidney Dis Transpl Source Type: research

The effect of hypothyroidism on serum irisin level in patients with nondiabetic chronic kidney disease: A pilot study with a cross-sectional design.
The objective of this study was to evaluate the effect of hypothyroidism on serum irisin level in patients with nondiabetic CKD. Two hundred nondiabetic CKD patients aged between 18 and 65 years with glomerular filtration rate
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Patil MM, Parameswaran S, Kamalanathan S, Sahoo JP, Balachandran K, Kar SS Tags: Saudi J Kidney Dis Transpl Source Type: research

The burden of caring for renal patients: The nurses perspective.
This study evaluated the burden experienced by nurses caring for CKD patients, identified the procedures causing the caregiving burden and factors associated with burden in two hospitals in Ondo State, Nigeria. Two hundred and forty nurses caring for renal patients were selected from two health institutions in Ondo State. Information on sociodemographic data was obtained using a self-administered questionnaire. The burden of care was evaluated using the Zarith Burden of Life Instrument (ZBI), with aggregate score ranged from 0-88. A score of 21-40 indicates mild-to-moderate burden while a score>40 indicates high burden....
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Mobolaji-Olajide OM, Amira OC, Ademuyiwa IY, Arogundade FA, Duke E Tags: Saudi J Kidney Dis Transpl Source Type: research

Experience with arteriovenous fistula creation for maintenance hemodialysis in a tertiary hospital in South-Western Nigeria.
We present our experience on AVF creation over a 10-year period. Our objective was to retrospectively review the outcome of all cases of AVF that have been created for ESRD patients at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife Nigeria between January 2006 and December 2015. The demographic characteristics, indications, clinical and intraoperative findings, operative complications and outcomes were filled into a pre-designed proforma. A total of 80 cases were reviewed. The age range was 17-80 years, with a mean of 49.03 ± 16.34 years. Males (85%) were more common than females (15%). Chronic g...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Salako AA, Badmus TA, Igbokwe MC, David RA, Laoye A, Akinbola IA, Onyeze CI, Babalola RN Tags: Saudi J Kidney Dis Transpl Source Type: research

Spectrum of renal allograft biopsy: A five-year experience at a tertiary care center of Eastern India.
Abstract Renal allograft dysfunction (RAD) can have myriad causes and presentations. Allograft biopsy remains the gold standard for optimum management. This is a retrospective study carried out at a tertiary care institute from August 2011 to March 2016. Details of the renal allograft biopsy requisitions were recorded and analyzed. Two hundred and two patients had undergone kidney transplantation (KT) during the study period. One hundred and twenty-six had undergone renal biopsy for RAD. The acute asymptomatic rise of serum creatinine was the most common clinical presentation (47.61%) followed by chronic RAD (CRAD...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Patil MR, Divyaveer SS, Mahajan C, Choudhury AR, Dasgupta S, Sarkar D, Riyait H, Abraham A, Pandey R Tags: Saudi J Kidney Dis Transpl Source Type: research

Incidence and factors associated with seroconversion to hepatitis C virus seropositivity amongst patients on maintenance hemodialysis, Douala-Cameroon.
Abstract Hepatitis C virus (HCV) infection one of the most common blood-borne infections is endemic in Cameroon and a serious problem in hemodialysis (HD). We aimed to determine the annual incidence and factors associated with seroconversion to hepatitis C positivity amongst patients on maintenance HD after an exposition of two years in a center with a high prevalence of hepatitis C (20.6%) and where no isolation policy is practiced. This was a retrospective cohort study carried out in January 2015 in the HD unit of Douala General Hospital in Cameroon including 71 patients on maintenance HD who tested negative for...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Halle MP, Larry T, Okalla C, Mefo'o N, Hermine F, Ashuntantang G Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinical spectrum of hospital acquired acute kidney injury: A prospective study from Central India.
Abstract Acute kidney injury (AKI) is a common disorder worldwide that is associated with severe morbidity, mortality and cost. If managed adequately and in a timely manner, the majority of these cases are preventable, treatable and often reversible with simple measures. We conducted a two years prospective study of patients admitted to medical and surgical units of a tertiary care center in Central India to identify the causes of Hospital Acquired AKI (HAAKI) and its impact on patient outcomes. HAAKI occurred in 215 of 9,800 patients (2.1%). Sepsis (75; 34.88%), volume depletion and hypo perfusion (62; 28.83%), d...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Goswami S, Pahwa N, Vohra R, Raju BM Tags: Saudi J Kidney Dis Transpl Source Type: research

Epidemiology and outcome of acute kidney injury from a tertiary care hospital in India.
Abstract We aimed to study the epidemiology and outcome of acute kidney injury (AKI). This is a prospective study of adults aged 18 years or above diagnosed with AKI over a period of 16 months at a tertiary care hospital. Three hundred and nine patients had AKI. The observed incidence of AKI was eight per 1000 admissions. About 92.2% had community-acquired AKI (CA-AKI), and in 7.8% it was hospital-acquired AKI (HA-AKI). Etiological factors for AKI were medical in 87.4% of the cases, surgical in 9.4%, and obstetric 3.2%. Sepsis was the most common (53.1%) etiology of AKI among the medical cases. Among sepsis, scrub...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Vikrant S, Gupta D, Singh M Tags: Saudi J Kidney Dis Transpl Source Type: research

Nephromegaly in an infant with atypical hemolytic-uremic syndrome resolving successfully with eculizumab.
We report a case of 11-month-old male infant who presented at the age of two months with anemia, acute kidney injury, hypertension, and nephromegaly. Renal biopsy confirmed the diagnosis of aHUS and Eculizumab was started. Thrombotic microangiopathy markers showed the resolution. Kidney sizes improved after nine months of Eculizumab therapy. The successful resolution of nephromegaly in an infant with aHUS has not been reported so far in literature. Renal sizes should be monitored in all children with aHUS. PMID: 30152436 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Kumar G Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute renal infarction induced by heavy marijuana smoking.
Abstract Acute renal infarction usually occurs in patients with severe atherosclerosis or valvular heart disease. We here report a 42-year Saudi male who presented with severe abdominal pain nausea and vomiting associated with hematuria, after heavy smoking of marijuana. Computed tomography abdomen revealed bilateral renal infarction. Serum anti phospholipids antibody and anti-cardio lipid antibody were positive. To the best of our knowledge, the association between marijuana and secondary lupus anticoagulant-induced renal infarction has not been reported previously. PMID: 30152437 [PubMed - in process] (Sour...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Al-Hwiesh AK, Bahbhani H, Alhwiesh A, Saad I, AlMohama F Tags: Saudi J Kidney Dis Transpl Source Type: research

Hematuria secondary to aeromonas infection in a kidney transplant recipient.
Abstract Urinary tract infection is the most common bacterial infection occurring in renal transplant recipients and is associated with significant morbidity. The etiology and site of origin of hematuria in the transplant recipient is similar to that of the general population. Aeromonas species have been found to cause infection in immunocompromised hosts including patients of chronic kidney disease. To the best of our knowledge, there has not been any case report regarding the infection of Aeromonas in kidney transplant recipients. PMID: 30152438 [PubMed - in process] (Source: Saudi Journal of Kidney Disease...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Hussain SS, Farhat S, Jasuja S Tags: Saudi J Kidney Dis Transpl Source Type: research

Sarcoidosis with multiple organ involvement associated with necrotizing crescentic glomerulonephritis.
We report a case of a young Saudi male who presented with generalized body weakness and easy fatigability associated with fever, night sweating, loss of weight and appetite, and renal impairment. He was diagnosed as a case of sarcoidosis, and renal biopsy report was consistent with necrotizing crescentic glomerulonephritis (GN). Immunosuppressive medication was started to help halting the progression to renal failure and stabilize renal function. To the best of our knowledge, the association between sarcoidosis and crescentic GN has been reported in only few cases in literature. PMID: 30152439 [PubMed - in process] (S...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Al-Hwiesh AK, Abdul-Rahman IS, Alhwiesh A, Al-Oudah N, Alratroo JA, Al-Oudah N, Al-Muhanna FA, Alsharani H, Ibrahim EF, Al-Durayash I, Al-Mubark AJ Tags: Saudi J Kidney Dis Transpl Source Type: research

Encapsulating peritoneal sclerosis with steroid-resistant massive ascites successfully treated by peritoneal lavage.
Abstract Encapsulating peritoneal sclerosis (EPS) is the most serious complication of long-term peritoneal dialysis (PD). EPS is diagnosed by clinical symptoms (abdominal pain, nausea, vomiting, diarrhea, and anorexia.) and image study (intestinal expansion, peritoneal thickening and calcification, and ascites.). Steroid therapy and surgery are recommended as the treatment of EPS. Here, we report a case of EPS with steroid-resistant massive ascites successfully treated with peritoneal lavage. A 59-year-old female with end-stage kidney disease secondary to hypertension was started on PD in 2003. Due to recurrent ex...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Kaneshiro N, Imai N, Sakurada T, Shibagaki Y Tags: Saudi J Kidney Dis Transpl Source Type: research

An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis.
We report a case of systemic lupus erythematosus (SLE) who presented with rapidly progressive renal failure (RPRF) with positive antinuclear antibody (ANA) and anti-double-stranded DNA (dsDNA) antibody and active urinary sediment in the form of microscopic hematuria and proteinuria. Provisional clinical diagnosis of lupus nephritis was made. Renal biopsy showed pauci-immune crescentic glomerulonephritis, the diagnosis of which was supported by positive serum anti-MPO antibody. Renal biopsy in SLE patients can sometimes reveal varied pathological entities such as antinuclear cytoplasmic antibodies (ANCAs) positive vasculiti...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Balwani MR, Bawankule C, Khetan P, Ramteke V, Tolani P, Kute V Tags: Saudi J Kidney Dis Transpl Source Type: research

Hypercalcemic crisis as a prodromal feature of Pneumcystis jirovecii pneumonia.
We describe a patient who had developed hypercalcemic crisis, with altered mental status and renal failure, one year following aggressive corticosteroid-therapy for lupus nephritis. Her disease relapsed after successful live-related kidney transplantation 11 years ago. She had normal parathyroid hormone and 25-hydroxyvitamin D yet high 1,25 dihydroxyvitamin D. Four weeks later, she developed severe dyspnea and hypoxia with a reticulonodular pattern on chest computed tomography. Bacteriological and serological tests were negative for pathogens. However, bronchoalveolar lavage established the diagnosis of Pneumocystis jirovi...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: El-Reshaid K, Al-Bader S Tags: Saudi J Kidney Dis Transpl Source Type: research

Alkaptonuria, a new association of distal renal tubular acidosis.
Abstract Alkaptonuria (ALK) is a rare genetic disorder, characterized by binding of ochronotic pigment to the connective tissues in different tissues. This is the first report of a child presented with primary distal renal tubular acidosis associated with ALK. Both disorders were managed by their specific medical treatments, with no further complication. PMID: 30152443 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Nickavar A, Azar MR Tags: Saudi J Kidney Dis Transpl Source Type: research

Distal renal tubular acidosis in sickle cell anemia.
We report a rare case of two young male siblings with sickle cell anemia who presented with bilateral lower limb deformities, failure to thrive, polyuria, and polydipsia. On investigations, they were found to have normal anion gap metabolic acidosis, hypokalemia, and nephrocalcinosis were seen on ultrasonography of the kidneys. These reports were suggestive of distal renal tubular acidosis (dRTA). They were started on oral alkali replacement and potassium therapy with which clinical improvement was seen. Conventionally, renal tubular dysfunction is thought to occur infrequently in patients with sickle cell anemia. Hence, w...
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Bharani A, Manchanda R, Singh RK, Prashant S Tags: Saudi J Kidney Dis Transpl Source Type: research

Diabetes mellitus and end-stage renal disease.
PMID: 30152445 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Mousavi Movahhed SM, Beladi Mousavi SS, Akbarpour S Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury and disseminated intravascular coagulation complicating hepatitis A.
PMID: 30152446 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Pahadiya HR, Lakhotia M, Gandhi R, Choudhary A Tags: Saudi J Kidney Dis Transpl Source Type: research

Ureteral obstructive nephropathy due to compression by intrinsic endometriosis of the ovary.
PMID: 30152447 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Bono L, Li Cavoli G, Giammarresi C, Turdo R, Li Cavoli TV, Oliva B, Caputo F Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevention of severe acute kidney injury by implementation of care bundles: Some progress but still a lot of work ahead.
Abstract Routine health data, dating from 1990 to 2015, show a dramatic rise in the incidence of acute kidney injury (AKI) in the general population and an apparent increase in acute dialysis (AKI-D) prompting calls for improvement of care in AKI patients. Recent reports suggest flattening of population-based AKI occurrence rates or declining frequencies of AKI or AKI-D in subgroups of high-risk patients with known onset of AKI. These temporal changes in AKI occurrence relate at least in part to the widespread implementation of AKI prevention care bundles. Nevertheless, AKI frequencies and AKI morbidity and mortal...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Schiffl H Tags: Saudi J Kidney Dis Transpl Source Type: research

Improvement in dialysis-related adverse events with use of body composition monitoring.
This study aims to utilize body composition monitor (BCM) device to achieve euvolemic status in problematic dialysis patients and to evaluate its clinical outcome. One hundred and five hemodialysis (HD) patients were enrolled based on difficulty in achieving dry weight. The reasons for enrollment in the study were (a) recurrent intradialytic hypotension, (b) intradialytic hypertension, (c) intradialytic muscle cramps, or (d) the presence of comorbid conditions that make clinical assessment of dry weight difficult (e.g., cirrhosis of liver, heart failure, severe malnutrition, or morbid obesity). Following initial assessment...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Raza SH, Hashmi MN, Elairon P, Riolo AH, Hejaili F, Al-Sayyari AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Correlation and discrepancy of phospholipase A2 receptor staining in membranous nephropathy in paraffin-embedded kidney biopsies.
Abstract Distinguishing primary from secondary forms of membranous nephropathy (MN) in paraffin-embedded kidney biopsies is challenging. Previous studies have measured the accuracy, sensitivity, and specificity of phospholipase A2 receptor (PLA2R) on MN. However, due to the absence of a gold standard method for diagnosis, further studies are necessary. Here, we measure the correlation and discrepancy of PLA2R on MN in paraffin-embedded kidney biopsies by correlating PLA2R findings with immunofluorescence (IF), light microscopy (LM), and electron microscopy (EM) results. A total of 116 kidney biopsies were investig...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Alwahaibi NY, Alrawahi UY, Alriyami MA Tags: Saudi J Kidney Dis Transpl Source Type: research

Fibroblast growth factor-23 as a predictor biomarker of acute kidney injury after cardiac surgery.
Abstract Renal ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). The lack of early biomarkers for predicting AKI has hampered our ability to initiate preventive and therapeutic measures in an opportune way. Fibroblast growth factor 23 (FGF-23) is elevated in chronic kidney disease, but data on FGF-23 in humans with AKI are limited. Herein, we tested whether FGF-23 levels rise early in the course of AKI following cardiac surgery. We prospectively evaluated eighty adult patients who underwent cardiac surgery. Patients were divided into two groups (AKI and non-AKI group) on the basis of wheth...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Shaker AM, El Mohamed E, Samir HH, Elnokeety MM, Sayed HA, Ramzy TA Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of blood pressure in children with idiopathic overactive bladder syndrome.
Abstract Children with an overactive bladder generally exhibit frequency, urgency, and urge incontinence. Often, a child will squat to try to prevent urinary incontinence. The bladder in these children is not anatomically and is functionally, smaller than normal and exhibits strong uncontrolled contractions. The aim of this study was to the evaluation of blood pressure (BP) in children with idiopathic overactive bladder syndrome. In this case-control study, we selected 110 children with overactive bladder as cases and 220 children without overactive bladder as controls. Children with overactive bladder and healthy...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Yousefichaijan P, Khosrobeigi A, Soltani M, Ghandi Y, Mojtahedi F Tags: Saudi J Kidney Dis Transpl Source Type: research

Combined use of Vitamins E and C improve nephrotoxicity induced by colistin in rats.
This study was performed to investigate the protective effect of combined use of Vitamins E and C on colistin-induced tubular damage in rat. Animals were treated with sterile saline, colistin methanesulfonate (CMS), CMS + Vitamin E + Vitamin C, and Vitamin E + vitamin C, respectively, for seven days. Thereafter, animals were sacrificed and the urine N-acetyl-b-D-glucosaminidase (NAG) and gamma-glutamyl transferase (GGT) levels, plasma level of creatinine (Cr), vitamin E and vitamin C, and renal tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as r...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Ghlissi Z, Hakim A, Mnif H, Zeghal K, Rebai T, Boudawara T, Sahnoun Z Tags: Saudi J Kidney Dis Transpl Source Type: research

Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats.
Abstract Liver and renal dysfunction accompanying with the tissues' oxidative damage has been reported to occur during Inflammation. Nigella sativa has been well known for its antioxidant and anti-inflammatory effects. The aim of this study was to investigate preventive effects of N. sativa on liver and renal tissue damage in lipopolysaccharide (LPS) -treated rats. The rats were divided into five groups: (1) control; (2) LPS (1 mg/kg, IP, for 10 days), (3-5) N. sativa hydroethanolic extract (100, 200, or 400 mg/kg) before LPS. Compared to LPS group, treatment by the extract decreased alondialdehyde, nitric oxide (...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Beheshti F, Norouzi F, Abareshi A, Khazaei M, Alikhani V, Moussavi S, Biglari G, Soukhtanloo M, Hosseini M Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence of cardiac arrhythmia and risk factors in chronic kidney disease patients.
This study aimed to investigate the prevalence of cardiac arrhythmia in CKD patients and to evaluate the relationship between arrhythmia and biochemical and echocardiographic parameters. CKD patients between 18 and 80 years of age were enrolled from the nephrology outpatient clinic. Physical examination, complete blood count, urinalysis biochemical analysis, electrocardiogram, echocardiogram, and 24-h Holter electrocardiogram were performed. Patients with and without cardiac arrhythmia were compared regarding their characteristics, laboratory findings, and echocardiographic parameters. Risk factors for cardiac arrhythmia w...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Kaya B, Paydas S, Aikimbaev K, Altun E, Balal M, Deniz A, Kaypakli O, Demirtas M Tags: Saudi J Kidney Dis Transpl Source Type: research

Pulmonary function tests and plasma nitric oxide levels in pediatric hemodialysis.
This study was performed among 20 patients on regular HD and 20 controls. Participants were subjected to clinical examination, and pulmonary function evaluation was performed using spirometry. The following parameters were obtained as follows: forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), Tüffenau index (FEV1/%FVC), (FEF25%-75%), and peak expiratory flow. Spirometry was carried out before and after HD sessions, and at the same time of clinical assessments, blood samples were taken to measure arterial-blood gas (ABG) and NO levels. There was the statistically significant difference between patien...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Youssef DM, Shokry DM, Elbehidy RM, Mohammed Khedr MK Tags: Saudi J Kidney Dis Transpl Source Type: research

The pathological evaluation of nonneoplastic kidney disorder in tumor nephrectomy specimens.
Abstract Renal cell carcinoma (RCC) comprises 2%-3% of all visceral and 80%-85% of all adult kidney malignancies. Nephrectomy is the treatment of choice for renal tumors. The accurate pathological evaluation of nonneoplastic renal parenchyma in nephrectomy specimens is important for subsequent management. Eighty-two patients with RCC who underwent surgery at Imam Khomeini Hospital, Urmia, Iran, from April 2006 to February 2015 were studied. Paraffin blocks of the hospital archives were stained by hematoxylin and eosin (H and E) and periodic acid-Schiff staining. Microscopic examination was performed on nontumoral ...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Noroozinia F, Makhdoomi K, Behnamfard H, Mohammadi S, Dindarian S, Bagheri M, Mohammadi H Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole.
This study was done on 23 children with frequently relapsing SSNS treated with levamisole besides steroids, then followed up three months; 16 males and seven females (mean age: 7.96 years and median 8 years). Clinical and laboratory assessments were done before starting therapy and after three months including cumulative dose of steroids and serum IL-18. We found that IL-18 level showed a significant elevation after three months of levamisole therapy compared to its level before initiation of levamisole therapy, with no relapses in these three months, no reported side effect, and significant reduction of cumulative dose of...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Youssef DM, Abd Al-Atif AM, El-Khateeb SSH, Elshal AS Tags: Saudi J Kidney Dis Transpl Source Type: research

Drug-induced acute interstitial nephritis: Prospective randomized trial comparing oral steroids and high-dose intravenous pulse steroid therapy in guiding the treatment of this condition.
Abstract The most important aspect of treating drug-induced acute interstitial nephritis (AIN) is timely discontinuation of the offending drug. Steroids, oral as well as intravenous (IV), are used in the treatment of drug-induced AIN. The present study was undertaken to compare the efficacy of oral prednisolone versus IV suprapharmacological doses of corticosteroids in the treatment of drug-induced AIN. This prospective randomized controlled study included drug-induced AIN diagnosed on histopathology over a period of two years. Patients were randomized to oral prednisolone (Group A) 1 mg/kg for two weeks or pulse ...
Source: Saudi Journal of Kidney Diseases and Transplantation - May 1, 2018 Category: Urology & Nephrology Authors: Chowdry AM, Azad H, Mir I, Najar MS, Ashraf BM, Muzafar WM, Ahmed WI Tags: Saudi J Kidney Dis Transpl Source Type: research