Comparison of serum levels of hepcidin and pro-hepcidin in hemodialysis patients and healthy subjects.
This study was designed to determine the role of changes in the level of serum hepcidin in the management of hemodialysis patients. This study included 44 dialysis patients and 44 controls. The hepcidin and pro-hepcidin levels were measured by the enzymelinked immunosorbent assay method. The serum ferritin level was measured by the chemiluminescence method. The mean hepcidin level was 999.3 ± 996.7 ng/mL in the case group and 770.4 ± 815.9 ng/mL in the control group (P = 0.25). The mean pro-hepcidin level was, respectively, 186.1 ± 220.3 pg/mL and 150.87 ± 207.7 pg/mL, in the case group and cont...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Taheri N, Gh Roshandel, Mojerloo M, Hadad M, Mirkarimi H, Nejad RK, Joshaghani HR Tags: Saudi J Kidney Dis Transpl Source Type: research

The effect of on-line hemodiafiltration on improving the cardiovascular function parameters in children on regular dialysis.
Abstract The cardiovascular disease is an important cause of morbidity and accounts for almost 50% of deaths in patients undergoing maintenance dialysis. Many harmful molecules of the uremic milieu, such as the middle molecules, are difficult to remove by conventional hemodialysis (HD). On-line hemodiafiltration (OL-HDF) can achieve a considerable clearance of middle molecules and, together with its sterile ultrapure infusate, may have favorable effects on inflammation and cardiovascular complications. We aimed in this study to assess the effect of OL-HDF on improving the chronic inflammatory state associated with...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Fadel FI, Makar SH, Zekri H, Ahmed DH, Aon AH Tags: Saudi J Kidney Dis Transpl Source Type: research

Rituximab as a rescue therapy in patients with glomerulonephritis.
Abstract To evaluate the use of rituximab in the treatment of severe glomerulonephritis (GN) in order to prevent progression of kidney disease toward the end stage, we designed a multicenter, retrospective study in Saudi Arabia about the efficacy and safety of the use of "off label" rituximab in a variety of severe refractory GN to conventional treatment and the progression of kidney disease for at least one year of follow-up. All the patients had kidney biopsies before treatment with rituximab, and proteinuria and glomerular filtration rate (GFR) were followed-up for the period of the study. The immedia...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Souqiyyeh MZ, Shaheen FA, Alsuwaida A, Alghonaim M, Alwakeel J, Mosa D, Akhtar F, Rahman E, Husain M, Roujouleh H, Siddiqi N, Bukhari I, Sadaqa N, Mushtaque F, Awn NM, Shariya F, Alfi A, Amin M, Ahmad M, Rowaie FA, Almueilo S, Kechrid MC, Karkar A Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury in severe acute pancreatitis: An experience from a tertiary care center.
Abstract Acute kidney injury (AKI) is an important cause of morbidity and mortality in severe acute pancreatitis (SAP). We aimed in our study to explore the risk factors of AKI in patients with SAP and assess the prognosis of patients with SAP and AKI. This is a retrospective study consisting of analysis of outcome and complications encountered in 72 severe acute pancreatitis patients admitted to a tertiary care center at Indore, India, from May 2011 to April 2012. We encountered 14 AKI cases in the SAP study patients. There was a significant association of diabetes and alcohol with AKI in patients with SAP. Alcoh...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Kumar R, Pahwa N, Jain N Tags: Saudi J Kidney Dis Transpl Source Type: research

Effects of Salacia oblonga on cardiovascular risk factors in chronic kidney disease patients: A prospective study.
Abstract The present study is aimed to evaluate the effect of the herbal drug Salacia oblonga on reduction of cardiovascular risk factors in patients with chronic kidney disease (CKD). Sixty patients were randomized in four groups; group A1 = non-diabetic CKD given trial drug Salacia oblonga for six months, group A 2 = non-diabetic CKD intended to receive placebo, group B1 = diabetic CKD treated with Salacia oblonga for six months and group B 2 = diabetic CKD patients intended to receive placebo. Estimation of renal function tests including blood urea, serum creatinine and creatinine clearance was performed at bas...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Singh RG, Rathore SS, Wani IA, Usha, Agrawal A, Dubey GP Tags: Saudi J Kidney Dis Transpl Source Type: research

Incidence of acute kidney injury in the neonatal intensive care unit.
Abstract The aim of this work is to study the incidence of acute kidney injury (AKI) in neonates admitted to the neonatal intensive care unit (NICU) over a six-month period from September 2011 to March 2012. This prospective study was performed on 250 neonates admitted to the NICU at the Children's Hospital, Faculty of Medicine, Zagazig University. All neonates were subjected to detailed history taking, including pre-natal, natal and post-natal history, with stress on symptoms suggestive of AKI. All neonates were examined thoroughly and the following investigations were performed: Blood urea nitrogen (BUN), serum ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Youssef D, Abd-Elrahman H, Shehab MM, Abd-Elrheem M Tags: Saudi J Kidney Dis Transpl Source Type: research

Exploring the opinion of hemodialysis patients about their dialysis unit.
Abstract Hemodialysis (HD) patients are subjected to a number of physical and mental stresses. Physicians might be unaware of some of these problems. We assessed our patients' opinion about the service provided at the dialysis unit. Our unit has 89 patients on HD. A questionnaire exploring our patients' opinion relative to the service provided was prepared. The patients were asked to fill-in the questionnaire in a confidential manner. Questionnaires were then collected and examined while unaware of patient identities. Sixty-nine patients (77.5%) responded to the questionnaire. Eight patients (11.6%) revealed their...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Donia AF, Elhadedy MA, El-Maghrabi HM, Abbas MH, Foda MA Tags: Saudi J Kidney Dis Transpl Source Type: research

Therapeutic efficacy of a biosimilar epoetin alfa in hemodialysis patients.
Abstract Anemia is a frequent complication in patients with chronic kidney disease. However, human recombinant erythropoietin (rHu-EPO) has revolutionized the management of anemia in chronically dialyzed patients. Epomax ® is a new rHu-EPO alfa manufactured in Tunisia (Medis Laboratories). The aim of this study was to evaluate the efficacy and tolerance of Epomax ® in chronic hemodialysis (HD) patients in a phase-III, multicenter, clinical trial. Fiftythree HD patients (mean age 47.7 ± 13 years) who received a stable dose of rHu-EPO (Hemax ® , a rHu-EPO alfa manufactured by Biosidus Laboratories...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Harzallah A, Zouaghi K, Dridi A, Boubaker K, Beji S, Ayari M, El Younsi F, Moussa FB, Kheder A Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of the effect of duration on dialysis on echocardiographic parameters: A preliminary study.
Abstract The excessive cardiovascular mortality seen in patients with end-stage renal disease seems to be closely related to accelerated coronary atherosclerosis. Some echocardiographic parameters such as left ventricular mass and diastolic dysfunction are implicated in ventricular dysfunction and mortality. The aim of the present study was to evaluate the effect of duration on dialysis on some echocardiographic parameters. We enrolled 75 patients on hemodialysis, including 34 women, in our prospective study. The mean age was 42.5 ± 13.8 years. The echocardiographic parameters were all measured within 2 h a...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Ellouali F, Berkchi F, Elhoussni S, Bayahia R, Benamar L, Abouqal R, Cherti M Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation of thyroid hormone levels in chronic kidney disease patients.
Abstract We attempted in this study to determine the thyroid hormone levels in 45 adult chronic kidney disease (CKD) patients and 45 ageand sex-matched healthy subjects as controls. The serum thyroid hormone levels were measured by a radioimmunoassay. Serum concentrations of creatinine, urea, electrolytes and total proteins and albumin were measured as well. There was a significant decrease in the levels of serum total T3, total T4 and total protein and albumin levels in CKD patients when compared with the controls. There was a significant increase in the level of thyroid stimulating hormone in the CKD patients co...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Rajeev G, Chickballapur Rayappa WD, Vijayalakshmi R, Swathi M, Kumar S Tags: Saudi J Kidney Dis Transpl Source Type: research

Polyomavirus-associated nephropathy in renal and simultaneous pancreas-kidney transplant recipients: Report of three cases.
Abstract Infection with polyomavirus (BK virus) is the cause of renal graft losses in more than 50% of the infected cases. There should be a high index of suspicion about this disease, although the incidence is only between 2% and 5% as the future of renal graft depends on the early and appropriate management of the same. Herein, we describe three clinical cases: Two were those of kidney transplant and the third, a combined kidney-pancreas transplant. In these cases, by reducing immunosuppression and, in one case, replacing the calcineurin inhibitor by MTOR (mammalian target of rapamycin) in addition, we were able...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Cadavid D, Mesa L, Schweineberg J, Posada JG Tags: Saudi J Kidney Dis Transpl Source Type: research

Strongyloides stercoralis infection in kidney transplant recipients.
We present three cases of renal transplant recipients who developed Strongyloides infection following transplantation. A bronchoalveolar lavage specimen, a duodenal biopsy and/or a stool specimen from these patients revealed evidence of S. stercoralis larvae. The first two patients received kidneys from the same deceased donor, a native of Bangladesh, an area that is highly endemic for S. stercoralis. The data suggest that the first two cases might be donor derived. High-risk donors and recipients should be screened for Strongyloides infection to initiate treatment before transplantation thus reducing morbidity and mortali...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Abdalhamid BA, Al Abadi AN, Al Saghier MI, Joudeh AA, Shorman MA, Amr SS Tags: Saudi J Kidney Dis Transpl Source Type: research

Carcinoma of the tongue in a renal transplant recipient: A rare post-transplant malignancy.
We report here a case of squamous cell carcinoma of the tongue in an adult male patient who developed it 11 years post-transplant. He underwent right hemiglossectomy and his graft function remained stable. PMID: 25579725 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Prakash J, Prabhakar, Kumar M, Aralapuram K Tags: Saudi J Kidney Dis Transpl Source Type: research

Successful recovery from iatrogenic severe hypernatremia and severe metabolic acidosis resulting from accidental use of inappropriate bicarbonate concentrate for hemodialysis treatment.
We report a case of iatrogenic severe hypernatremia (sodium 207 mEq/L) and severe metabolic acidosis (pH 6.65) that resulted due to accidental use of inappropriate bicarbonate concentrate for hemodialysis treatment. There was successful recovery in this patient with no neurological sequelae. To the best of our knowledge, this is the first case report in adults of severe hypernatremia along with severe metabolic acidosis due to error in the preparation of dialysis fluid. PMID: 25579726 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Bhosale GP, Shah VR Tags: Saudi J Kidney Dis Transpl Source Type: research

Pregnancy in peritoneal dialysis and an infant with a ventricular septal defect.
Abstract Fertility is markedly reduced in dialysis patients. Estimates of the frequency of conception in dialysis patients range from 1.4% per year in Saudi Arabia to 0.5% in the United States. The reasons for the rarity of pregnancy in dialysis patients are not well understood. In addition, there is a marked increase in the risk of pre-eclampsia, hydramnios, hypertension crisis, early uterine contractions and pre-term delivery. Herein, we report a 38-year-old Saudi woman with chronic renal failure who completed the full term of pregnancy uneventfully on peritoneal dialysis. Using a biocompatible dialysate solutio...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Alhwiesh A Tags: Saudi J Kidney Dis Transpl Source Type: research

Mesangioproliferative glomerulonephritis in a patient with Kimura's disease presenting as Nephrotic syndrome.
Abstract Kimura's disease is a rare chronic eosinophilic inflammatory disorder of unknown etiology. Majority of cases have been reported from South East Asia, while sporadic occurrences have been reported worldwide, including the Indian subcontinent. Nephrotic syndrome may be the presenting manifestation of Kimura's disease, and a variety of renal lesions are observed histologically in such patients. We herein describe a case of steroid-responsive mesangioproliferative glomerulonephritis related to kimura's disease. PMID: 25579728 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Rathore SS, Arora P, Usha, Prakash J Tags: Saudi J Kidney Dis Transpl Source Type: research

Distal renal tubular acidosis with nerve deafness secondary to ATP6B1 gene mutation.
Abstract Autosomal recessive distal renal tubular acidosis (dRTA) is associated with mutation in the ATP6B1 gene encoding the B1 subunit of H + -ATPase, one of the key membrane transporters for net acid excretion of α-intercalated cells of medullary collecting ducts. Sensori-neural deafness frequently accompanies this type of dRTA. We herewith describe a patient who had distinct features of dRTA with bilateral sensori-neural hearing loss and ATP6B1 mutation. This is a rare entity. PMID: 25579729 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Naveen PS, Srikanth L, Venkatesh K, Sarma PV, Sridhar N, Krishnakishore C, Sandeep Y, Manjusha Y, Sivakumar V Tags: Saudi J Kidney Dis Transpl Source Type: research

Lithium overdose: Early hemodialysis is the key!
Abstract A 65-year-old gentleman was referred to our hospital with encephalopathy and renal failure. His medications included lithium for the treatment of bipolar disorder. The clinical examination and the laboratory investigations that followed revealed findings classical of lithium overdose. The patient was successfully managed and discharged from the hospital on Day 9 of admission. Clinicians should be aware of this rather unusual and relatively rare differential cause of acute on chronic renal failure with encephalopathy. PMID: 25579730 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Goel S, Nasa P, Gupta A, Gupta R, Taneja S Tags: Saudi J Kidney Dis Transpl Source Type: research

Metformin-related acidosis in a woman while performing Haj: A conservative approach.
Abstract Metformin is a first-line oral anti-hyperglycemic agent. It decreases insulin resistance, decreases hepatic glucose output and enhances peripheral glucose uptake. Metformin is used as a monotherapy in combination with other oral hypoglycemic agents. A major side-effect of metformin is lactic acidosis. The elimination of metformin is mainly through the kidneys, and raised plasma concentrations can cause lactic acidosis. Provided there is no overdose, metforminassociated lactic acidosis rarely develops in patients without co-morbidities such as renal or hepatic insufficiency, acute infection or severe dehyd...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Ansari RS, Mady AF, Qutub HO, Althomaly E, Alzayer ZA, Moulana AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Intraperitoneal streptokinase use-associated eosinophilic peritonitis.
We report a case of a middle aged male who was initiated on continuous ambulatory peritoneal dialysis. Because of inadequate inflow and outflow of dialysis fluid, he was given two doses of intraperitoneal streptokinase after ruling out other causes. After the use of intraperitoneal streptokinase, there was turbid effluent with culture showing Staphylococcus aureus. Even after the successful treatment of bacterial peritonitis with intravenous antibiotics, he continued to have turbid effluent, with a predominance of eosinophils in the effluent cell count. A diagnosis of EP was made and he was managed with the antihistaminic ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Rathi M Tags: Saudi J Kidney Dis Transpl Source Type: research

Amyloidosis in Behcet's disease.
We report some cases of BD-associated amyloidosis and have similar features. The patients developed nephrotic syndrome due to secondary amyloidosis, which was refractory to the immunosuppressive agents. Two patients expired and the third was lost to follow-up during the course. The BD complicated with amyloidosis is associated with high mortality despite the current aggressive therapy. PMID: 25579733 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Ghorbel IB, Feki NB, Salem TB, Lamloum M, Houman MH Tags: Saudi J Kidney Dis Transpl Source Type: research

Arterovenous fistula creation using the brachial artery and cubital fossa veins: A viable option in our environment.
PMID: 25579734 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Abubakar U, Liman HM, Makusidi AM, Agwu NP, Opara AC, Musa N, Nazish PA, Jamalu IR, Opara OO, Ukwuani SI Tags: Saudi J Kidney Dis Transpl Source Type: research

Plasmapheresis in renal diseases: Personal experience.
PMID: 25579735 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Cavoli GL, Bono L, Tortorici C, Ferrantelli A, Giammarresi C, Rotolo U Tags: Saudi J Kidney Dis Transpl Source Type: research

Epidemiologic and demographic characteristics of a hemodialysis patient in Quchan, Iran.
PMID: 25579736 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Moshki M, Hashemizadeh H, Doulati SP Tags: Saudi J Kidney Dis Transpl Source Type: research

Diabetic nephropathy in hemodialysis patients in Constantine, Algeria.
PMID: 25579737 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Bouhabel A, Saadi N, Bendjeddou J, Laib Z, Hannache K, Aberkane A Tags: Saudi J Kidney Dis Transpl Source Type: research

Barriers to adequate urea clearance among hemodialysis patients in developing countries: An example from the Sudan.
PMID: 25579738 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Abdelwahab HH, Shigidi MM Tags: Saudi J Kidney Dis Transpl Source Type: research

Irreversible renal failure in two infants.
PMID: 25579739 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Sathe KP, Ali US, Ohri A Tags: Saudi J Kidney Dis Transpl Source Type: research

Chinese H7N9 bird flu: A concern on kidney involvement.
PMID: 25579740 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Wiwanitkit S, Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Eligibility for renal transplantation: A Moroccan interregional survey.
Abstract In the treatment of end-stage renal disease, kidney transplantation (KT) is the best and most cost-effective alternative with regard to both prognosis and quality of life. To identify the proportion and the characteristics of kidney transplant candidates who can be considered eligible, a total of 2066 hemodialysis patients were investigated as part of the ARTEMIS (Attitude toward Renal Transplantation and Eligibility among dialysis patients in a Moroccan Interregional Survey) study. We investigated all patients receiving hemodialysis in the 39 centers of four Moroccan departments. The mean age was 52.9 ye...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Kabbali N, Mikou S, El Bardai G, Najdi A, Ezziani M, Batta FZ, El Pardiya NT, El Fadil C, El Hassani A, Arrayhani M, Houssaini TS Tags: Saudi J Kidney Dis Transpl Source Type: research

Proteinuria in Egyptian renal transplant recipients.
Abstract To evaluate the prevalence, risk factors, possible etiology, prognosis and management of proteinuria in renal transplant recipients, we studied 435 adult renal transplant recipient patients randomly selected from our center; 394 patients were reviewed retrospectively and 41 patients were followed-up prospectively for a period of one year. The patients were classified into three groups according to the results of urinalysis and spot urinary albumin creatinine ratio: Group A patients with normoalbuminuria; Group B patients with microalbuminuria; and Group C patients with macroalbuminuria. Persistent post-tr...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Khedr E, El Sharkawy M, El Shahawy Y, Sany D, Sayed H Tags: Saudi J Kidney Dis Transpl Source Type: research

Spectrum of intradialytic complications during hemodialysis and its management: A single-center experience.
This study was performed to evaluate the various intradialytic complications that occur during HD and their management. This is a retrospective study performed in patients who underwent conventional HD during the period of 1 January 2000 to 31 December 2011 at our center. Clinical details, various complications faced and their management were retrieved from dialysis case sheets. A total of 2325 patients of renal failure (790 ARF and 1535 CRF patients) were assessed for the intradialytic complications of HD. During the study period, there were 12,785 bicarbonate dialyses performed on these patients. In the ARF patients, the...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Prabhakar, Singh RG, Singh S, Rathore SS, Choudhary TA Tags: Saudi J Kidney Dis Transpl Source Type: research

Focal and segmental glomerulosclerosis: Does prognosis vary with the variants?
Abstract Focal and segmental glomerulosclerosis (FSGS) is a clinicopathological entity. The following five FSGS variants: Collapsing, cellular, glomerular tip, peri-hilar and not otherwise specified (NOS) are recognized, which may have prognostic value. The aim of this study was to highlight the clinical course and outcome in the different pathological variants of FSGS and to evaluate the predictive risk factors of end-stage renal disease (ESRD). It was a retrospective analysis of biopsy-proven primary FSGS patients who presented over a period of three years. The data were collected from the clinical and biopsy re...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2015 Category: Urology & Nephrology Authors: Swarnalatha G, Ram R, Ismal KM, Vali S, Sahay M, Dakshinamurty KV Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of allograft function using diffusion-weighted magnetic resonance imaging in kidney transplant patients.
Abstract Developing a non-invasive method such as diffusion-weighted magnetic resonance imaging (DWMRI) could be used as a feasible and reproducible modality in the differential diagnosis of allograft dysfunction. We assessed the functional status of the renal allograft by DWMRI and its applicability in assessment of graft dysfunction on all end-stage renal transplant patients who attained normal renal function on the 7 th day post-transplantation. Follow-up imaging of the recipient allograft was performed at the end of 90 and 180 days and in case of graft dysfunction. Kidney biopsies were performed to correlate w...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Kaul A, Sharma RK, Gupta RK, Lal H, Jaisuresh, Yadav A, Bhadhuria D, Prasad N, Gupta A Tags: Saudi J Kidney Dis Transpl Source Type: research

Effect of intraoperative human albumin on early graft function in renal transplantation.
Abstract Adequate intravascular volume maintenance is essential to ensure early graft function during renal transplantation. Various recommendations on optimum fluid therapy are based, at best, on sparse evidence, and that too only from observational studies. This prospective randomized controlled study was done to evaluate the effect of 20% human albumin on the early graft function in living donor renal transplantation. Eighty patients undergoing renal transplantation were randomly assigned to one of the intraoperative fluid regimens, 0.9% normal saline with 20% human albumin (albumin group) or 0.9% normal saline...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Shah RB, Shah VR, Butala BP, Parikh GP Tags: Saudi J Kidney Dis Transpl Source Type: research

The effect of mannitol administration to kidney donor on short-term outcomes of kidney transplantation.
Abstract As the cases of kidney transplant are increasing, the need to apply the factors to increase the success of transplant seems necessary. Mannitol increases the osmotic pressure and urine volume as a protective agent on renal tubules. We aimed to evaluate the effect of mannitol on short-term outcome of kidney transplantation by comparing two groups based on prescribing mannitol to donors. In a randomized clinical trial, 60 kidney recipients were assigned in two groups (30 in each), except that in one group donors received mannitol. They were studied with respect to age, gender, weight, blood urea nitrogen (B...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Esfahani HS, Nooraei N, Asgary M, Hashemian MR Tags: Saudi J Kidney Dis Transpl Source Type: research

Influence of p53 (rs1625895) polymorphism in kidney transplant recipients.
Abstract Reperfusion injury predisposes the kidney allograft to acute rejection. Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene. To determine the association between single nucleotide polymorphism (SNP) in the pro-apoptotic protein p53 (rs1625895) and acute rejection in renal transplants, we studied 100 recipients of kidney allografts and 100 healthy individuals served as controls. The polymorphism was determined by the polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) test. Overall, 31 recipients developed rejection. There was no differenc...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Azarpira N, Kazemi K, Darai M Tags: Saudi J Kidney Dis Transpl Source Type: research

Trends of elevated parathormone serum titers in hemodialysis patients on intensive therapy for bone disease: A multicenter study.
Abstract To determine the prevalence of controlled parathyroid hormone (PTH) serum levels with intensified therapy for chronic kidney disease mineral and bone disorder (CKD-MBD) in the dialysis population, we studied 563 chronic hemodialysis patients recruited from three different dialysis centers from three different major cities in the Kingdom of Saudi Arabia. The trend of the routine monthly chemistries related to CKD-MBD was evaluated besides the whole-molecule PTH serum levels over 28 months (January 2011 to April 2013). The cost ratios of the medications to the estimated dialysis total cost were calculated. ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Karkar A, Sinha AK, Abdelrahman M, Mushtaque F, Awn NM, Qadi Y, Nassar M, Algareeb A, Taha MI, Abdulkader M, Sabry A, Souqiyyeh MZ, Shaheen FA Tags: Saudi J Kidney Dis Transpl Source Type: research

The relationship between aortic knob width and various demographic, clinical, and laboratory parameters in stable hemodialysis patients.
Abstract Accelerated atherosclerosis is very common in hemodialysis (HD) patients and is related to morbidity and mortality. The aortic knob width (AKW), which can easily be calculated on chest radiographs has also been found to be related to atherosclerosis in patients with normal renal function. The importance of AKW in HD patients is not known. The current study is aimed to investigate factors associated with increased AKW in HD patients. The study participants had their medical history taken and a physical examination conducted, with calculation of dialysis adequacy and AKW. AKW was calculated from the chest x...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Afsar B, Saglam M, Yuceturk C, Agca E Tags: Saudi J Kidney Dis Transpl Source Type: research

The effect of a membrane dialyzer during hemodialysis on the antioxidant status and lipid peroxidation of patients with end-stage renal disease.
Abstract Renal failure is accompanied by oxidative stress, which is caused by enhanced production of reactive oxygen species (ROS) and an impaired antioxidant defense. We studied 73 hemodialysis (HD) patients (39 males and 34 females) aged 24-75 years; the patients were randomized into two subgroups according to the type of hemodialysis membrane (35 patients were dialyzed on cellulose and 38 patients on polysulfone F7/F9 membrane dialyzers) and we assessed their antioxidant and lipid peroxidation status levels. The total antioxidant status (TAS) levels including whole blood levels of malondialdehyde (MDA) and glut...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Ogunro PS, Olujombo FA, Ajala MO, Oshodi TT Tags: Saudi J Kidney Dis Transpl Source Type: research

Percutaneous versus laparoscopic placement of peritoneal dialysis catheters: Simplicity and favorable outcome.
Abstract Implantation of peritoneal dialysis (PD) catheters via the laparoscopic technique is expanding, but none of the studies concerning this technique have compared its outcome with the percutaneous insertion done by the nephrologist. We compared the technical survival and outcome of 52 PD catheters placed in 43 patients with end-stage renal disease (ESRD) in our center from March 2006 to October 2007. Of these, 27 PD catheters were inserted percutaneously by a nephrologist (group 1) and 25 were placed by a surgeon using the conventional laparoscopic technique (group 2). Very obese patients, those with previou...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Al-Hwiesh AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Do the outcomes of living donor renal allograft recipients differ with peritoneal dialysis and hemodialysis as a bridge renal replacement therapy?
This study was undertaken to compare the outcomes of living donor renal transplant recipients using peritoneal dialysis (PD) and hemodialysis (HD) as a bridge modality for renal replacement therapy till renal transplantation. The demographic profiles of the recipients and donors, the patients' native kidney disease (diabetic versus non-diabetic), duration on dialysis, requirement of anti-hypertensive drugs, number of blood transfusions, human leukocyte antigen (HLA) mismatch status, pre- and post-transplant infectious complications, and post-transplant outcomes of patients were compared between the two groups. The demograp...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Prasad N, Vardhan H, Baburaj VP, Bhadauria D, Gupta A, Sharma RK, Kaul A Tags: Saudi J Kidney Dis Transpl Source Type: research

Follow-up study of post-infectious glomerulonephritis in adults: Analysis of predictors of poor renal outcome.
Abstract Post-infectious glomerulonephritis (PIGN) still remains one of the most common glomerulonephritis in the developing world. We studied the epidemiology and clinical spectrum of PIGN in adults to identify the clinical, biochemical and histological factors that would predict renal outcome. Data of 102 adult PIGN patients treated between 2009 and 2011 with a mean fol-low-up of 12 months (6-36 months) were analyzed retrospectively. The mean age of the patients was 32.7 ± 15 years, with a male to female ratio of 1.2:1. At presentation, 99% of the patients had edema and oliguria, 73% had hypertension, 55%...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Natarajan G, Ramanathan S, Jeyachandran D, Balasubramaniyan T, Srinivasa Prasad ND, Thanigachalam D Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison between three supportive treatments for prevention of contrast-induced nephropathy in high-risk patients undergoing coronary angiography.
Abstract Contrast-induced nephropathy is the third most common cause of acute renal failure in hospitalized patients. The purpose of this study was to compare three supportive treat-ments for prevention of contrast-induced nephropathy in high-risk patients undergoing coronary angiography. In this randomized clinical trial study, 150 patients with at least one risk factor, such as, congestive heart failure, history of diabetes mellitus, age>65 years or renal failure were randomly assigned to three equal groups: First group (Sodium (Na) bicarbonate infusion), second group [(N-Acetylcysteine (NAC) + Sodium Chlorid...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Yeganehkhah MR, Iranirad L, Dorri F, Pazoki S, Akbari H, Miryounesi M, Vahedian M, Nazeri A, Hosseinzadeh F, Vafaeimanesh J Tags: Saudi J Kidney Dis Transpl Source Type: research

Neurocognitive functions and behavioral profiles in children with nephropathic cystinosis.
Abstract Children with nephropathic cystinosis (NCTN) have evidence of defective intellec-tual functions and behavioral disorders. This prospective study was performed to detect the cognitive dysfunctions in patients with this rare hereditary lysosomal storage disease, define their behavioral phenotypes, and study the findings on magnetic resonance imaging (MRI) of the brain. Thirteen patients with confirmed diagnosis of cystinosis (mean age ± SD 5.9 ± 3.0, range 1.5 - 12 years) were subjected to the Stanford Binet test, Porteus Maze test, Child Behavior Checklist, and MRI brain. Thirteen age- and se...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Aly R, Makar S, Bakri AE, Soliman NA Tags: Saudi J Kidney Dis Transpl Source Type: research

Preinduction hemodynamic fluctuations in renal transplant recipients-Comparison of two combined anesthesia regimens.
Abstract An ideal anesthetic technique for a renal allograft recipient must ensure hemodynamic stability, enhance graft reperfusion, and provide good postoperative pain relief. Hence, a combined general and epidural anesthesia is preferred. In our clinical practice, it has been observed that in chronically ill end-stage renal disease (ESRD) patients, a bolus injection of epidural local anesthetics invariably necessitated the use of vasopressor agents. Such hemodynamic fluctuations may not be favorable for the graft. A prospective, randomized, double-blind study was conducted on 50 ESRD adults, 18-55 years, schedul...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Sen I, Thomas S, Arya VK, Minz M Tags: Saudi J Kidney Dis Transpl Source Type: research

Performance of QuantiFERON TB Gold test in detecting latent tuberculosis infection in brain-dead organ donors in Iran: A brief report.
This study was conducted in the National Research Institute of Tuber-culosis and Lung Diseases (NRITLD) in Iran, from January to March 2013. A total of 38 conse-cutive brain-dead donors, not currently infected with active tuberculosis, were recruited. The medi-cal records of all the study enrollees were reviewed. A whole-blood IFN- release assay (IGRA) in reaction to early secreted antigenic target 6 (ESAT-6), culture filtrate protein 10 (CFP-10), and TB7.7 antigens, was performed and the released Interferon- was measured via enzyme-linked immunosorbent assay (ELISA). The data was analyzed with QFT-G software which was pro...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Tabarsi P, Yousefzadeh A, Najafizadeh K, Droudinia A, Bayati R, Marjani M, Shafaghi S, Farokhzad B, Javanmard P, Velayati AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Post-partum acute kidney injury.
In conclusion, several factors are involved in causing post-partum AKI in our population, and sepsis was the most common of them. PMID: 25394442 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Pahwa N, Bharani R, Kumar R Tags: Saudi J Kidney Dis Transpl Source Type: research

Skin, subcutaneous tissue, and allograft infection with Mycobacterium fortuitum in a renal transplant recipient.
We report a patient, who presented with nodular skin lesions one year post transplant, but the biopsy revealed a rare diagnosis - Mycobacterium fortuitum (M. fortuitum) infection of the skin, subcutaneous, and renal allograft. He was treated successfully with an initial two-week course of intravenous cefoxitin, followed by a six-month course of ciprofloxacin, clarithromycin, and co-trimoxazole. There are a few reported cases of M. fortuitum infection in renal transplant recipients in the literature - notably urinary tract infection, allograft infection, and psoas abscess, but to the best of our knowledge this is the first ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Mushtaq RF, Bappa A, Ahmad M, AlShaebi F Tags: Saudi J Kidney Dis Transpl Source Type: research

Double primary carcinoma in a renal allograft recipient.
We report a renal allograft recipient on triple immunosuppression with prednisolone, azathioprine and cyclosporine who presented with ductal infiltrating carcinoma of the right breast eight years post-transplant, followed two years later with left ovarian papillary carcinoma. PMID: 25394444 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Satish R, Rout P, Alexander B Tags: Saudi J Kidney Dis Transpl Source Type: research

Continuous venovenous hemodiafiltration along with charcoal hemoperfusion for the management of life-threatening lercanidipine and amlodipine overdose.
We describe a rare case of massive overdose of lercanidipine with shock, refractory to conventional therapies and multi-organ failure. Charcoal hemoperfusion with continuous venovenous hemodiafiltration was then used successfully and the patient showed remarkable recovery. PMID: 25394445 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Nasa P, Singh A, Juneja D, Singh O, Javeri Y Tags: Saudi J Kidney Dis Transpl Source Type: research