Risk factors associated with acute kidney injury in newborns.
Abstract Acute kidney injury (AKI) in the newborn is a common problem in the neonatal intensive care unit with many underlying factors such as asphyxia, respiratory distress syndrome (RDS), and urogenital anomalies. The aim of this study is to highlight possible risk factors and profile of neonates developing AKI in the Neonatal Intensive Care Unit (NICU) of Cairo University Pediatric Hospital. The study was carried out on 90 neonates (30 patients and 60 controls), among neonates admitted to NICU. The study was done over two months, from January 2015 to March 2015. Our study showed that sepsis was detected in 53.3...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Ghobrial EE, Elhouchi SZ, Eltatawy SS, Beshara LO Tags: Saudi J Kidney Dis Transpl Source Type: research

The epidemiology of acute peritonitis in end-stage renal disease patients on peritoneal dialysis in Qatar: An 8-year follow-up study.
Abstract Acute peritonitis (AP) is a common and devastating complication in end-stage renal disease patients on peritoneal dialysis (PD). We are reporting an epidemiologic study of AP in Qatar over 8-year follow-up. We retrospectively reviewed medical records of all PD patients in Qatar from 2007 to 2014. The analysis was conducted to report epidemiology, outcome, and associated risk factors of AP. We had 318 AP episodes in 180 patients between 2007 and 2014. Six (3.3%) patients died as a result AP. Six cases of fungal peritonitis were reported. AP rate has decreased from 1 episode/29.7 PD-months in 2007 to 1/43.7...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Hamad A, Ismail H, Elsayed M, Kaddourah A, Ahmed H, Ibrahim R, Ali A, Alali F Tags: Saudi J Kidney Dis Transpl Source Type: research

Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients.
Abstract We aimed to study the association of fibroblast growth factor-23 (FGF-23) as a novel cardiovascular risk factor with Doppler pulse wave velocity (PWV) as an arterial stiffness measuring tool in hemodialysis (HD) patients. We conducted a cross-sectional study in which blood samples from 86 HD patients were obtained to estimate FGF 23 and other parameters. Flow waveforms were obtained at two locations within right common carotid artery, and right femoral artery by Doppler ultrasound with ECG recorded in addition. The time differences between the R wave of the ECG signal and the onset of the flow waveforms a...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Ibrahim WH, Ahmad AB, Sayed NG Tags: Saudi J Kidney Dis Transpl Source Type: research

Outcome of renal transplant recipients with cytomegalovirus and BK polyomavirus co-infection nephropathy.
Abstract Reactivation of cytomegalovirus (CMV) and BK polyomavirus (BKV) can result in virus-associated tubulointerstitial nephritis in renal allografts. All those renal biopsies reported as viral cytopathic were isolated and examined by two independent renal histopathologists from our institute and classified as CMV, BKV, and CMV-BKV coinfection-associated viral cytopathic changes with confirmation through polymerase chain reaction technology in either serum or urine or both. All twenty patients were categorized as 10 in CMV, four in BKV, and six were in CMV-BKV coinfection. One patient each had received antithym...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Kaul A, Kumar S, Bhaduaria D, Agrawal V, Sharma RK, Prasad N, Gupta A, Kumar R Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison of survival between dialysis patients with incident high-flux hemodialysis versus on-line hemodiafiltration: A single center experience in Saudi Arabia.
This study is a retrospective, single-center study in which 78 patients were screened; 18 were excluded and 60 patients were analyzed. The study patients were aged 47.5 ± 20.7 years, 33 patients (55%) were on HF-HD, and 27 patients (45%) were on OL-HDF. A total of 24 patients (40%) of both groups were diabetic and, the mean duration on dialysis was 43.5 ±21.3 months in the HF-HD group and 41.2 ± 22.0 months in the OL-HDF group. The mean substitution volume for OL-HDF was 22.3 ± 2.5 L. Survival was 73% [95%, confidence interval (CI) 60-84] in the HF-HD group and 65% (95%, CI 54-75) in the OL-HDF ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Abdelsalam MS, Rashwan M, Althaf MM, Alfurayh OI, Alkorbi L, Ibrahim IA Tags: Saudi J Kidney Dis Transpl Source Type: research

The cardiovascular risk factor profiles among end-stage renal failure patients treated with continuous ambulatory peritoneal dialysis and intermittent hemodialysis.
This study was conducted to evaluate the burden factors of CV risk factors and its management in our regularly dialyzed patients. It was a single-center, cross-sectional analysis of prevalent intermittent hemodialysis (IHD) and continuous ambulatory peritoneal dialysis (CAPD) patients followed up in our hospital. Both the traditional and non-traditional CV risk factors were recorded and compared between the two groups. Eighty-eight patients were recruited. Forty-five were treated with CAPD and 43 patients were treated with IHD. The mean age was 49.5 ± 15.17 years old and 54.5% were females. Eighty percent were Malay...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Zamiah SAKS, Draman CR, Seman MR, Safhan AF, Rozalina R, Nik Ruzni NI Tags: Saudi J Kidney Dis Transpl Source Type: research

Vascular access mortality and hospitalization among hemodialysis patients in Palestine.
We examined all-cause mortality and hospitalization in patients being dialyzed through HD catheters as compared to patients with AV access. A total of 382 patients were included in the study. Of these, 88 had catheters and 294 had AV accesses. Seventy-eight percent of all catheters were temporary nontunneled dialysis catheters. The overall gross mortality rate for all patients was 14.7%. Gross mortality was significantly lower among AV access group compared to the catheter group (12.2% vs. 22.7%; P = 0.015). Catheter use was associated with a relative hazard ratio (HR) of 1.85 [95% confidence interval (CI), 1.13-3.03] comp...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Hamadneh SA, Nueirat SA, Qadoomi' J, Shurrab M, Qunibi WY, Hamdan Z Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal anemia syndromes in iraqi hemodialysis patients according to iron status.
Abstract Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013. Seventy prevalent adult HD Iraqi patients were enro...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Ali A, Salih RM Tags: Saudi J Kidney Dis Transpl Source Type: research

Descriptive analysis of glomerulonephritis by histological type and their progression among adults in a tertiary care center in Sri Lanka.
Abstract Prevalence of different glomerulonephritides and their clinical course vary geographically. Our objectives are to assess the prevalence of different histological types of glomerulonephritis (GN) based on the light microscopic histology and to assess their progression according to histological type. A retrospective cross-sectional study was carried out among adult patients (>18 years) with a histological diagnosis of GN at the University Professorial Unit over a period of six months. Information including demographic data, renal biopsy findings, and progression of the disease through serum creatinine (S...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Gunawardena KW, Wijewickrama ES, Arambepola C, Lanerolle RD Tags: Saudi J Kidney Dis Transpl Source Type: research

Importance of renal biopsy in patients aged 60 years and older: Experience from a tertiary care hospital.
This study outlines the importance of renal biopsy in elderly and describes the clinical and pathologic spectrum of renal diseases in patient ≥60 years. All patients (age ≥60 years) undergoing renal biopsies from January 2011 to December 2014 were included in this retrospective study. The clinical presentation and biochemical findings were recorded, and the patients were grouped based on their clinical presentation. Renal biopsies were also evaluated. The mean age of patients was 67.7 ± 6.4 years with a male:female ratio of 3:1. The most common clinical manifestation was nephrotic syndrome (37.4%) followed by ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Gupta P, Rana DS Tags: Saudi J Kidney Dis Transpl Source Type: research

Comparison between brief food frequency questionnaire and food record to assess the energy and protein intake of hemodialysis patients at Dr. Sardjito Hospital in Indonesia.
This study was conducted on March to April 2015 in HD Unit of Dr. Sardjito Hospital, Indonesia, as an observational study. This was a cross-sectional study. Data were collected from 103 patients, who were selected using a purposive sampling method. All participants' dietary intakes were assessed using a food record and the BFFQ to obtain total protein and energy intakes. Wilcoxon test was used for the statistical analysis. There was a significant difference (P
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Wulandari H, Susetyowati, Prasanto H Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and risk factors of chronic kidney disease in Cote D'Ivoire: An analytic study conducted in the department of internal medicine.
The objective of this study was to describe the current profile of CKD in our working conditions. This is a descriptive retrospective study of patients admitted for CKD during the period from January 2010 to December 2014 in the Internal Medicine Department of the university hospital of Treichville in Abidjan. CKD was defined by a glomerular filtration rate below 60 mL/min lasting for at least three months. We collected 252 cases of CKD out of 3573 patients recorded during the study period, yielding a prevalence of 7%. The mean age was 39.6 ± 14 years (15-83 years). We observed a male predominance (sex ratio 1.2:1)....
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Yao HK, Konan SD, Sanogo S, Diopoh SP, Diallo AD Tags: Saudi J Kidney Dis Transpl Source Type: research

Knowledge and attitude toward organ donation among people in Lanja: A rural town in India.
Abstract Organ shortage is the greatest challenge facing the field of organ transplantation today. We aimed to study the attitude and knowledge toward body and organ donation among people in rural India. The present study was conducted in a rural town called Lanja, in the Konkan region of Maharashtra in India. A questionnaire covering demographic data, knowledge, and attitude of the participants was distributed to 400 students, middle-aged and senior citizens; 91.5% of the respondents were aware about organ donation. Television (55.2%) and newspaper (45.8%) were the most popular sources of information. About 56.2%...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Bharambe VK, Arole VU, Puranam V, Kulkarni PP, Kulkarni PB Tags: Saudi J Kidney Dis Transpl Source Type: research

Alport's syndrome with focal segmental glomerulosclerosis lesion - Pattern to recognize.
We report a case of a 42-year-old male presenting with proteinuria, microscopic hematuria, elevated serum creatinine and hypertension with unremarkable physical examination apart from obesity. The renal biopsy showed well-established FSGS pattern of injury with mild interstitial fibrosis and tubular atrophy, while the electron microscopic examination demonstrated glomerular basement membranes (GBM) changes compatible with AS. AS can be complicated by segmental glomerular scarring, which can mimic primary FSGS, while familial FSGS can result from mutations in collagen IV network of the GBM. This overlap can complicate histo...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Alsahli AA, Alshahwan SI, Alotaibi AO, Alsaad KO, Aloudah N, Farooqui M, Al Sayyari AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Perfused nonfunctioning renal allograft: Case report and review of the literature.
We report a case of very early postoperative iatrogenic dissection of common iliac artery (CIA), external iliac artery (EIA) causing acute ischemia of the right lower limb, and impairing the perfusion of a renal allograft. This was managed successfully by graft nephrectomy and interposition polytetrafluoroethylene grafting of the CIA and EIA with re-implantation of the kidney allograft and restoration of its perfusion and function, together with restoration of the lower limb circulation. PMID: 29456225 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Zahran M, Othman A, Saker AE, Wagih M, Soliman M, Badr M Tags: Saudi J Kidney Dis Transpl Source Type: research

Three cases of prune belly syndrome at the Lagos State University Teaching Hospital, Ikeja.
We report three cases; all referred after birth with lax abdominal wall, congenital anomalies of kidney, and urinary tract. One of the patients had an absent right foot. They all had cryptorchidism, and in one, there was deranged renal function. The reported cases had both medical and radiological interventions to varying degrees. They all had an abdominal ultrasound which revealed varying degrees of hydronephrosis, hydroureters, and bladder changes. Voiding cystourethrogram showed vesicoureteric reflux in one of the reported cases. Urinary tract infections were appropriately treated with antibiotics based on sensitivity. ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Solarin AU, Disu EA, Gbelee HO, Animasahaun AB, Aremu OE, Ogbuokiri E, Ogunnaike GO, Oladimeji A Tags: Saudi J Kidney Dis Transpl Source Type: research

A case of renal granulomatosis with polyangiitis following intravesical bacillus Calmette-Gu érin therapy.
We report here the case of a 67-year-old patient who presented with renal granulomatosis with polyangiitis following intravesical BCG therapy for superficial bladder tumor. The biological evaluation revealed the presence of perinuclear anti-neutrophil cytoplasmic antibodies with specificity for antimyeloperoxidase. Renal biopsy specimen revealed pauci-immune crescentic glomerulonephritis with segmental glomerular necrosis, presence of granulomas and no evidence of any caseating necrosis. He received antituberculosis drugs in addition to corticosteroids and cyclophosphamide without any improvement of the renal function. ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Selmi Y, Kheder-Elfekih R, Jebali H, Fatma LB, Smaoui W, Krid M, Beji S, Rais L, Zouaghi MK Tags: Saudi J Kidney Dis Transpl Source Type: research

Suttonella indologenes peritonitis in a patient receiving continuous ambulatory peritoneal dialysis.
Abstract Suttonella indologenes is a Gram-negative, aerobic coccobacillus of Cardiobacteriaceae family and its natural habitat is the mucous membranes of the upper respiratory system. The literature includes limited number of case reports concerning fatal endocarditis due to infection in the prosthetic heart valves caused by the aforementioned microorganism. However, there is no information on extracardiac involvement due to this microorganism. Here, we present a peritonitis case caused by Suttonella indologenes in a patient receiving continuous ambulatory peritoneal dialysis. PMID: 29456228 [PubMed - in proc...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Sevencan NO, Bakirdogen S, Adar A, Kayhan B Tags: Saudi J Kidney Dis Transpl Source Type: research

Page kidney: A rare but surgically treatable cause of hypertension.
We report two cases of young males with flank pain, renal mass, and hypertension with history of blunt abdominal trauma. Initially, hypertension was controlled by angiotensin-converting enzyme (ACE) inhibitors but gradually became refractory to medical treatment. Laparoscopic nephrectomy was performed in both patients. We emphasize the Page kidney as a cause of hypertension in young patients, presenting with flank pain and renal mass with or without complications of hypertension. Management is aimed to control blood pressure by ACE inhibitors, aspiration of the hematoma, open hematoma evacuation, or nephrectomy. PMID:...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Sokhal AK, Prakash G, Saini DK, Singh K, Sankhwar S, Singh BP Tags: Saudi J Kidney Dis Transpl Source Type: research

Isolated renal involvement of cytomegalovirus inclusion disease in an infant.
Abstract Cytomegalovirus (CMV) is the most common cause of congenital infections in humans occurring in 1% of all liveborns. Symptomatic congenital CMV infection involves multiple systems and causes significant morbidity and mortality in newborns. Isolated CMV infection of the kidneys in a living infant has not been reported in literature. Here, we report an infant who presented only with renomegaly and renal biopsy showed extensive CMV inclusions. Serum and urine polymerase chain reaction for CMV were positive, and CMV involvement of other organs was ruled out. The child for treated with intravenous ganciclovir a...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Murugananth S, Padmaraj R, Gopalakrishnan N, Manorajan R, Kurien AA, Dhanapriya J, Dineshkumar T, Sakthirajan R Tags: Saudi J Kidney Dis Transpl Source Type: research

Late-onset choreoathetotic syndrome following heart surgery in adults with end-stage renal disease.
Abstract Choreoathetotic syndrome is a rare complication of open cardiac surgery that is seen usually in children after surgery for congenital cardiac anomalies. Here, we report two cases of adult patients with end-stage renal disease (ESRD) on regular hemodialysis who developed acute choreoathetotic syndrome few days after cardiac surgeries under cardiopulmonary bypass (CPB). Improvement was seen after an interval with complete resolution in one case. Investigations of the cause have been noncontributory. Long CPB time seems to be the main identified risk factor in these cases. One of the unusual features of our ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Hamzi MA, Hassani K, El Kabbaj D Tags: Saudi J Kidney Dis Transpl Source Type: research

Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis.
We present here a patient on hemodialysis who developed seizures after receiving two doses of TXA over 5 h period. PMID: 29456232 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Fuah KW, Lim CTS, Pang DCL, Wong JS Tags: Saudi J Kidney Dis Transpl Source Type: research

Recurrent episodic myoglobinuric acute kidney injury as presenting manifestation of idiopathic polymyositis.
Abstract Polymyositis (PM) is a rare heterogeneous group of disorders with frequent multisystem involvement including uncommon renal manifestations. Acute kidney injury (AKI) as the primary manifestation of PM is extremely rare. Herein, we report a case of recurrent episodic AKI in an adult female who was subsequently diagnosed to have PM. PMID: 29456233 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Marisiddappa L, Desai AM, Kedlaya PG, Sathish R Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute cellular rejection with coexisting tuberculous interstitial nephritis in renal allograft.
PMID: 29456234 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Padmanabhan A, Gadgil NM, Chandrakar S, Kumavat P Tags: Saudi J Kidney Dis Transpl Source Type: research

Second delivery for a woman on hemodialysis: Prospects for the mother and the children.
PMID: 29456235 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Pipili C, Kiosses D, Hatzigeorgiou-Sandberg G Tags: Saudi J Kidney Dis Transpl Source Type: research

Scleroderma renal crisis.
PMID: 29456236 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Cavoli GL, Bono L, Calogera T, Giammarresi C, Li Cavoli TV, Nuara G Tags: Saudi J Kidney Dis Transpl Source Type: research

Bisphosphonate-related osteonecrosis of the jaw in a chronic hemodialysis patient.
PMID: 29456237 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2018 Category: Urology & Nephrology Authors: Yilmaz SG, Yılmaz F Tags: Saudi J Kidney Dis Transpl Source Type: research

Senescent chronic kidney disease: The challenges faced and the strategies to overcome.
This article seeks to bring a consensus in sorting out these practical problems so that a systematic way of approach could be arrived at in managing such fragile patients. The last decade has seen an evolution and ongoing refinement of a disease-oriented approach to CKD. Since the average GFR tends to decrease with age, CKD becomes increasingly prevalent with advancing age, and thus, disproportionately elderly patients meet the criteria for CKD. PMID: 29265034 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Jayaraman R, Ganapathy E, Balakrishnan S, Prashanth S, Akila R Tags: Saudi J Kidney Dis Transpl Source Type: research

Serum cystatin C levels in Healthy Nigerian neonates: Is there a need for normative values in Nigerian babies?
Abstract Cystatin C is an endogenous marker of renal function. Normal reference values have been documented in neonates outside Africa, but no study has been documented in African neonates. With reports that race may affect serum cystatin C values, this study was carried out to generate normal values in apparently healthy term neonates at birth and three days of life neonates in Nigeria. This was a hospital-based prospective study. A cohort of 120 apparently healthy term neonates were recruited at birth. Serum cystatin C was measured from the cord blood at birth and venous blood when they were three days old using...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Madise-Wobo AD, Gbelee OH, Solarin A, Animasahun BA, Njokanma OF Tags: Saudi J Kidney Dis Transpl Source Type: research

Neutrophil chemokines levels in different stages of nephrotic syndrome.
This study included 125 patients who were divided into 40 patients with nephrotic range proteinuria (NRP), 45 patients with NS, and 40 patients who were in remission. This study also included 80 healthy participants as a control group. Enzyme-linked immunosorbent assay was used for the determination of the plasma levels of GRO-α, GCP-2, and IL-8. GCP-2 plasma levels were significantly higher in the NS and NRP groups when compared to the control group, whereas the GRO-α and IL-8 levels were significantly higher in all patient groups in comparison with the control group. All these chemokine levels were significan...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Alsharidah AS, Alzogaibi MA, Bayoumy NM, Alghonaim M Tags: Saudi J Kidney Dis Transpl Source Type: research

Leukocyte esterase reagent strip as a bedside tool to detect peritonitis in patients undergoing acute peritoneal dialysis.
In this study, we evaluated the use of leukocyte esterase reagent strip (LERS) as a bedside test to diagnose peritonitis in patients undergoing acute PD. Patients who underwent acute PD were monitored for signs and symptoms of peritonitis. PD effluent fluid analysis included TLC, absolute neutrophil count, Gram-stain, and culture for the diagnosis of peritonitis. LERS (Multistix 10SG) was simultaneously dipped in PD effluent fluid and read at two minutes. Reading of + was considered as indicative of peritonitis. Twenty-one out of 166 (12.6%) patients undergoing acute PD developed peritonitis. LERS detected peritonitis in 2...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Rathore V, Joshi H, Kimmatkar PD, Malhotra V, Agarwal D, Beniwal P, Dawra R, Gupta P Tags: Saudi J Kidney Dis Transpl Source Type: research

Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat.
This study shows that the mixed extracts of N. sativa and CL have positive synergistic effects on renal damage in nephropathy induced by ADR in rats. PMID: 29265038 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Mohebbati R, Shafei MN, Beheshti F, Soukhtanloo M, Roshan NM, Anaeigoudari A, Parhizgar S, Hosseinian S, Khazdeir MR, Rad AK Tags: Saudi J Kidney Dis Transpl Source Type: research

A pragmatic randomized controlled trial comparing pathway-based versus usual care in community-acquired acute kidney injury.
Abstract Clinical pathways have shown conflicting evidence in improvement of several patient-centered outcomes across different clinical settings. However, the effectiveness of clinical pathway in management of acute kidney injury (AKI) has not been reported. Therefore, we aimed to assess the length of hospital stay (LOS) and patient-centered outcomes in community acquired AKI and compared pathway care (PC) versus usual care (UC). The CHAMP-Path AKI Trial is a pragmatic, parallel, single-blind randomized controlled trial. Physicians were randomized to provide either UC or PC. Patients were randomized through a com...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Almalki AH, Ismail SE, Qureshi MA, Abunijem Z, Balla ME, Karsou S, Qureshi RA, Ahmad A, AlSulami S, Khalil M, Hafez J, Thomson JEH, Siddiqui MA, Yusuf OB, Zahrani ZA, Gasim A, Mujtaba Quadri KH Tags: Saudi J Kidney Dis Transpl Source Type: research

Impact of pharmaceutical care on the health-related quality of life among hemodialysis patients - A multicenter randomized controlled study.
Abstract The present study was planned to assess the impact of pharmaceutical care on the health-related quality of life (HRQoL) among hemodialysis (HD) patients. An open-label, randomized control study was carried out at three different HD centers of teaching, government, and corporate hospitals in South India. The patients were randomized into two groups (Usual Care Group [UC] and Pharmaceutical Care Group [PC]) by block design method. The PC group received the normal care along with pharmaceutical care delivered by a qualified registered pharmacist. The assessment of the HRQoL was carried out at baseline, 6th a...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Mateti UV, Nagappa AN, Attur RP, Nagarapu SP, Rangaswamy D Tags: Saudi J Kidney Dis Transpl Source Type: research

Nutrition screening tools as predictor of malnutrition for hemodialysis patients in Dr. Sardjito Hospital in Yogyakarta, Indonesia.
The objective parameters were the following: Body mass index (BMI), mid-upper-arm circumference (MUAC), handgrip strength (HGS), and a three-day food record. Chi-squared test, t-test, and receiving operating characteristic curve were used for the statistical analysis. In predicting malnutrition, the validity of the SNST is better than the NRS 2002 in MHD patients against either SGA (Se 94.3% vs. 82.9%; Sp 60% vs. 58.6%; and area under curve (AUC) 0.847 vs. 0.749) or DMS (Se 90.0% vs. 81.6%; Sp 74.0% vs. 62.8%; and AUC 0.833 vs. 0.746), while the NRS 2002 is better than the SNST based on BMI, MUAC, HGS, and energy intake (P
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Susetyowati S, Djarwoto B, Faza F Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinical outcomes of nephrotic syndrome in immunoglobulin a nephropathy.
We report a retrospective analysis of our experience on the clinical outcomes of nephrotic syndrome in patients with IgA nephropathy, in the nephrology department of a provincial hospital in South Korea. Thirty-three patients with biopsy-proven IgA nephropathy with nephrotic syndrome were enrolled between March 1990 and March 2013. We analyzed data according to demographic, clinical, and laboratory records. The mean follow-up duration was 62 ± 45 months (10-204) in 33 patients. Complete remission occurred in 10 steroid-users and two steroid-nonusers. Partial remission occurred in seven steroid-users, and eight stero...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Jeong EG, Hyoun S, Lee SM, An WS, Kim SE, Son YK Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury due to overcorrection of hypovitaminosis D: A tertiary center experience in the Kashmir Valley of India.
Abstract Vitamin D deficiency state is endemic in the Kashmir valley of the Indian subcontinent. Clinicians frequently treat patients with Vitamin D for diverse clinical symptoms to improve the general health and to reduce the frailty of elderly and these doses may at times be inappropriately high. Vitamin D toxicity-induced acute kidney injury (AKI), often considered rare, can be life-threatening and associated with substantial morbidity if not identified promptly. We aimed to describe clinical and biochemical features, risk factors, and management of AKI patients with Vitamin D toxicity seen at a single tertiary...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Chowdry AM, Azad H, Najar MS, Mir I Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinicopathological study of nondiabetic renal disease in type 2 diabetic patients: A single center experience from India.
Abstract Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM), leading to chronic kidney disease/end-stage renal disease. Wide spectrum of nondiabetic renal diseases (NDRD) is reported in type-2 diabetes (type-2 DM). We carried out this single-center study to find clinical, laboratory, and histological features of NDRD in type-2 DM patients and to assess the prevalence of NDRD in India. A single-center retrospective study which included analysis of renal biopsies from patients with type-2 DM, performed between January 2008 and September 2016. Biopsy findings were categorized into three group...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Kanodia KV, Vanikar AV, Nigam L, Patel RD, Suthar KS, Patel H Tags: Saudi J Kidney Dis Transpl Source Type: research

Assessment of abdominal aortic calcification in predialysis chronic kidney disease and maintenance hemodialysis patients.
In conclusion, the prevalence of AAC varies mainly with age and glomerular filtration rate levels in predialysis CKD patients. Advanced age, time on dialysis, and inflammation may be associated with presence and extent of AAC in HD patients. Further research into the risk factors and outcome for AAC is warranted. PMID: 29265045 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Dhakshinamoorthy J, Elumalai RP, Dev B, Hemamalini AJ, Venkata Sai PM, Periasamy S Tags: Saudi J Kidney Dis Transpl Source Type: research

Factors associated with relapse of lupus nephritis: A single center study of 249 cases.
Abstract This is a retrospective cohort study over 20 years (1990-2013) that included all patients with biopsy-proven lupus nephritis (LN) followed up at our nephrology department. We aimed to determine the clinicobiologic predictors of flare-up of LN. Flare was defined as an increase in systemic lupus erythematosus (SLE) disease activity index (SLEDAI) score of at least four points. Clinical manifestations and laboratory parameters were assessed and the SLEDAI score was determined for each patient. We included patients with SLE who fulfilled at least four of the American College of Rheumatology criteria for the c...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Hajji M, Harzallah A, Kaaroud H, Barbouch S, Hamida FB, Abdallah TB Tags: Saudi J Kidney Dis Transpl Source Type: research

Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients.
Abstract Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages in cardiovascular protection with a low risk of hypoglycemia. Few studies have measured lactic acid blood levels in patients with diabetic kidney disease on metformin and demonstrated lactic acidosis. The aim of our study is to see if patients with diabetic kidney disease are at risk of elevated lactate blood levels and lactic acidosis. Lactate levels and blood pH were estimated in patients with type 2 diabetes mellitus receiving metformin in different stage...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Bipi PK, George J, Gomathy S, Gracious N, Kumar S, Mohandas MK Tags: Saudi J Kidney Dis Transpl Source Type: research

The diagnosis of tuberculosis in dialysis patients.
This study investigates the spectrum of clinical presentations and outcome in dialysis patients during a nine-year period. TB was diagnosed in 41 patients. Anti-TB drugs, adverse effects of therapy, and outcome were noted. Thirty-eight patients (92.6%) were on hemodialysis and three were on peritoneal dialysis (7.3%). The mean age at diagnosis was 50.8 years and the male/female ratio was 1.16. Four patients had a history of pulmonary TB. Extrapulmonary involvement was observed in 32 (78 %) patients. The bacteriological confirmation was made in 41.46% and histological confirmation was made in 26.83%, and in the rest, the di...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Jebali H, Barrah S, Rais L, Kheder R, Khouja N, Mhiri SN, Beji M, Abdelmalek R, Tiouiri H, Smaoui W, Beji S, Hmida FB, Fatma LB, Zouaghi MK Tags: Saudi J Kidney Dis Transpl Source Type: research

Current state of continuous ambulatory peritoneal dialysis in Egypt.
Abstract Patients with end-stage renal disease (ESRD) continue to increase in number worldwide, especially in developing countries. Although continuous ambulatory peritoneal dialysis (CAPD) has comparable survival advantages as hemodialysis (HD), it is greatly underutilized in many regions worldwide. The prevalence of use of CAPD in Egypt is 0.29/million population in 2017. The aim of this study is to describe the current state and practice of CAPD in Egypt and included 22 adult patients who were treated by CAPD. All the study patients were switched to CAPD after treatment with HD failed due to vascular access pro...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Elzorkany KMA Tags: Saudi J Kidney Dis Transpl Source Type: research

Left ventricular hypertrophy among predialysis chronic kidney disease patients: Sindh institute of urology and transplantation experience.
In conclusion, early detection of LVH and control of risk factors may help to achieve a decrease in cardiovascular morbidity and mortality in patients with CKD. PMID: 29265050 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Ali T, Idrees MK, Shoukat, Akhtar SF Tags: Saudi J Kidney Dis Transpl Source Type: research

Pattern and predictors of urine protein excretion among patients with type 2 diabetes attending a single tertiary hospital in Lagos, Nigeria.
Abstract Testing for proteinuria is used to screen for diabetic nephropathy. However, significant proportion of diabetics has normal urine protein excretion despite impaired renal function. We aimed to determine the factors predicting increased urine protein excretion in patients with type 2 diabetes. This was a cross-sectional study of 358 type 2 diabetics attending the diabetes clinic of a teaching hospital in Lagos. Data regarding patients' demographic characteristics, and disease history were retrieved. Clinical measurement and samples for determination of plasma creatinine, and urine protein/creatinine ratio ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Bello BT, Amira CO Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and risk factors of chronic kidney disease in an african semi-urban area: Results from a cross-sectional survey in Gueoul, Senegal.
This study sought to describe the epidemiological characteristics and profile of CKD, as well as the related risk factors in Guéoul, a semi-urban zone in Senegal. An observational, cross-sectional, and descriptive study was conducted in Guéoul city in Senegal from November 1, 2012, to December 10, 2012, according to the WHO STEPS approach. People older than 35 years living in Guéoul city were included in the study. Cardiovascular and renal disease risk factor screening was conducted for this population. Data were analyzed using the 3.5.1 version of Epi Info software. The significance level was a P
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Faye M, Lemrabott AT, Cissé MM, Fall K, Keita Y, Ngaide AA, Mbaye A, Fary Ka EH, Niang A, Kane A, Diouf B Tags: Saudi J Kidney Dis Transpl Source Type: research

Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury.
Abstract Antiglomerular basement membrane (anti-GBM) disease is an uncommon autoimmune disease characterized by the presence of IgG autoantibodies targeting the alpha-3 chain of type IV collagen. Some of the atypical forms of the disease have been described. Herein, we describe a case of atypical anti-GBM in a 27-year-old Saudi male who presented with lower limb edema, gross hematuria, elevated serum creatinine concentration, and nephrotic-range proteinuria. All serology tests were negative, except for anti-GBM which was weakly positive. Renal biopsy showed proliferative glomerulonephritis (GN) with nodular transf...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: AlSowailmi B, AlSowailmi G, Aloudah N, Alsaad KO, Elhassan E, Al Sayyari AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Rapidly progressive glomerulonephritis due to anti-glomerular basement membrane disease accompanied by IgA nephropathy: An unusual association.
Abstract Anti-glomerular basement membrane (anti-GBM) disease is a systemic autoimmune disorder characterized by circulating IgG antibodies (rarely IgA and IgM) to the carboxyterminal, noncollagenous 1 (NC1) domain of type IV collagen of GBM also known as Goodpasture antigen. Patients typically present with rapidly progressive glomerulonephritis (RPGN) and pulmonary hemorrhage in the presence of which it is referred to as Goodpasture's disease. Anti-GBM disease has been reported to coexist with pauci-immune antineutrophil cytoplasmic autoantibody-positive glomerulonephritis and membranous glomerulopathy. The seque...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Annamalai I, Chandramohan G, Srinivasa Prasad ND, Fernando E, Sujith S Tags: Saudi J Kidney Dis Transpl Source Type: research

Proteinuria in children with juvenile idiopathic arthritis: Making the case for early urinary screening.
We report two pediatric cases with SOJIA and nephrotic syndrome secondary to renal amyloidosis, a very rare complication in children. Once present, amyloidosis heralds a poor prognosis for the patient, though early detection may allow some improvement if the inflammatory arthritis is controlled. PMID: 29265055 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Saha A, Pais P, Iyengar AA, Abraham AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury: A rare complication of mothball (Naphthalene) poisoning.
We present a diagnostic and therapeutic challenge encountered while treating a child with naphthalene-induced acute severe hemolytic anemia and acute kidney injury from accidental ingestion. PMID: 29265056 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2017 Category: Urology & Nephrology Authors: Ekambaram S, Chandan Kumar KM, Mahalingam V Tags: Saudi J Kidney Dis Transpl Source Type: research