Malignant hypertension-associated thrombotic microangiopathy following cocaine use.
We report the case of a patient who developed malignant hypertension associated with thrombotic microangiopathy after chronic consumption of cocaine. A kidney biopsy revealed thrombotic microangiopathy with fibrinoid necrosis of arterioles and glomerular tufts. He required dialysis sessions. Cocaine-mediated endothelial injury and platelet activation may play important pathogenetic roles in cocaine abusers who develop malignant hypertension associated with thrombotic microangiopathy. Clinicians need to be aware of this rare feature of cocaine intoxication. PMID: 26787585 [PubMed - in process] (Source: Saudi Journal of...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Lamia R, El Ati Z, Fatma LB, Zouaghi K, Smaoui W, Rania K, Krid M, Hmida FB, Béji S, Moussa FB Tags: Saudi J Kidney Dis Transpl Source Type: research

Use of high-dose prednisolone to overcome rifampicin-induced corticosteroid non-responsiveness in childhood nephrotic syndrome.
We report a child with nephrotic syndrome treated successfully with an increased dose of steroids without discontinuing anti-tubercular therapy. PMID: 26787586 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Barman H, Dass R, Duwarah SG Tags: Saudi J Kidney Dis Transpl Source Type: research

Unusual presentation of tuberculosis in the form of a bilateral renal pseudotumor.
Abstract Genitourinary tuberculosis (TB) is a common form of extrapulmonary tuberculosis. The kidneys are usually affected by hematogenous seeding at the time of primary pulmonary infection. Genitourinary TB has non-specific clinical presentations and variable radiographic appearances. We are reporting a case of genitourinary TB presenting as bilateral renal mass. The patient underwent computed tomography-guided kidney biopsy that showed a granulomatous lesion. Then, the patient was put on anti-tuberculous treatment with a good response. We feel that patients having multiple bilateral kidney lesions should undergo...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Singh SK, Singh A, Kumar A Tags: Saudi J Kidney Dis Transpl Source Type: research

Evaluation and therapy in four patients with Takayasu's arteritis.
In this report, treatment choices for four patients with the diagnosis of pediatric TA, their clinical and laboratory findings and their responses to treatment will be discussed. PMID: 26787588 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Conkar S, Mir S, Sözeri B, Bulut K, Çınar C Tags: Saudi J Kidney Dis Transpl Source Type: research

An unusual case of urinary incontinence in a post-renal transplant patient.
PMID: 26787589 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Kumar R, Mathur M, Garsa R, Agarwal D, Malhotra V, Yadav SS, Tomar V Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal transplantation erythrocytosis among recipients of kidney transplantation of Afro-Arab origin patients.
PMID: 26787590 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Elhafiz EM, Ahmed Abu Alga SA, Gibreel AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Severe forms of aspergillosis in patients on hemodialysis.
PMID: 26787591 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Jabrane M, Skandour D, Rochdi Y, Nouri H, Aderdour L, Raji A, Alaoui C, Fadili W, Laouad I Tags: Saudi J Kidney Dis Transpl Source Type: research

Nephrotic syndrome and situs inversus - A chance association?
PMID: 26787592 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: More VB, Saxena A, Sharma R Tags: Saudi J Kidney Dis Transpl Source Type: research

Muehrcke's line.
PMID: 26787593 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Kumar R, D'Souza AV, Malhotra V Tags: Saudi J Kidney Dis Transpl Source Type: research

National survey of the availability and use of urine microscopy in the United Kingdom.
PMID: 26787594 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2016 Category: Urology & Nephrology Authors: Malik S, Robertson S Tags: Saudi J Kidney Dis Transpl Source Type: research

Organ Transplantation in Saudi Arabia - 2014.
Authors: PMID: 26785511 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Tags: Saudi J Kidney Dis Transpl Source Type: research

Benefits and implementation of home hemodialysis: A narrative review.
Abstract Home hemodialysis (HD) is a modality of renal replacement therapy that can be safely and independently performed at home by end-stage renal disease (ESRD) patients. Home HD can be performed at the convenience of the patients on a daily basis, every other day and overnight (nocturnal). Despite the great and many perceived benefits of home HD, including the significant improvements in health outcomes and resource utilization, the adoption of home HD has been limited; lack or inadequate pre-dialysis education and training constitute a major barrier. The lack of self-confidence and/or self-efficacy to manage ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Karkar A, Hegbrant J, Strippoli GF Tags: Saudi J Kidney Dis Transpl Source Type: research

Transplant nephrectomy - A single-center experience.
Abstract Transplant nephrectomy (TN) is associated with significant morbidity and mortality and influences the outcome of subsequent renal transplantation. The aim of this study was to identify the reasons for TN in a single transplant center in the United Kingdom and to determine the complication rate, effect on relisting and re-transplantation. We studied all the TNs in our center from January 2000 to December 2011. Detailed information including cause of allograft failure and reason for TN were analyzed. Of 602 renal transplants performed at our center during the period of the study, 42 TNs were performed on 38...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Ariyarathenam A, Bamford A, Akoh JA Tags: Saudi J Kidney Dis Transpl Source Type: research

Is there a genetic predisposition to new-onset diabetes after kidney transplantation?
Abstract Kidney transplant recipients may develop new-onset diabetes after transplantation (NODAT) and transplant-associated hyperglycemia (TAH) (NODAT or new-onset impaired glucose tolerance-IGT). We studied 251 consecutive renal transplant South Asian recipients for incidence of NODAT and its risk factors between June 2004 and January 2009. Pre-transplant glucose tolerance test (GTT) identified non-diabetics (n = 102, IGT-24, NGT-78) for analysis. Baseline immunosuppression along with either cyclosporine (CsA) (n = 70) or tacrolimus (Tac) (n = 32) was given. Patients underwent GTT 20 days (mean) post-transplant ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Reddy YN, Abraham G, Sundaram V, Reddy PP, Mathew M, Nagarajan P, Mehra N, Ramachandran A, Ali AA, Reddy YN Tags: Saudi J Kidney Dis Transpl Source Type: research

Outpatient parenteral antibiotic therapy in a renal transplant population: A single-center experience.
This study describes OPAT outcomes within a UK teaching hospital renal transplant population. Renal function, mapped by estimated glomerular filtration rate (eGFR), and clinical response to infection were collected retrospectively. A total of 635 antimicrobial episodes were administered to nine renal transplant patients over 12 discrete OPAT courses during the study period. Eleven of 12 OPAT courses (91.67%) produced a clinical improvement in infection. One course was terminated due to immunosuppressive-related neutropenia. No patient required admission due to failure of OPAT or adverse events. There was no significant cha...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Harrison J, Hossain MA, Morsy M, Ghazanfar A Tags: Saudi J Kidney Dis Transpl Source Type: research

Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome.
Abstract To evaluate aortic stiffness in renal transplant patients and to determine the correlation of renal insufficiency and estimated glomerular filtration rate (eGFR) with aortic pulse wave velocity (APWV), we studied 96 renal transplant patients followed-up at our center. We measured the APWV using transcutaneous Doppler flow recordings and the foot-to-foot method, and calculated the eGFR using the Modification of Diet in Renal Disease equation. The study included 81 (84.4%) males and 15 (15.6%) females. The mean age of the patients was 37.84 ± 10.10 years. The mean duration of transplant was 47.90 &pl...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Ayub M, Ullah K, Masroor I, Butt GU Tags: Saudi J Kidney Dis Transpl Source Type: research

Tolerance and efficacy of a low dose of the calcimimetic agent cinacalcet in controlling moderate to severe secondary hyperparathyroidism in hemodialysis patients.
This study was designed to investigate the efficacy and tolerance of a low dose of the calcimimetic agent cinacalcet in patients on long-term HD having moderate to severe secondary hyperparathyroidism. Twentyfive adult male patients on HD for more than three years were included in the study. All had moderate to severe secondary hyperparathyroidism with serum intact parathyroid hormone (iPTH)>50 pmol/L, resistant to conventional treatment. We used the targets of Chronic Kidney Disease: Outcomes Quality Initiative (K/DOQI) clinical guidelines as optimal target of serum iPTH, calcium and phosphate. Patients were administer...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Bashir SO, Omer HA, Aamer MA, Somialy R, Morsy MD Tags: Saudi J Kidney Dis Transpl Source Type: research

The effect of gabapentin on muscle cramps during hemodialysis: A double-blind clinical trial.
Abstract Hemodialysis-associated muscle cramps (HAMC) are a common complication during hemodialysis (HD) sessions. A number of pharmacologic agents have been evaluated to prevent and or diminish HAMC; however, none of them has an established role. To the best of our knowledge, this is the first study to evaluate the possible effect of gabapentin on HAMC. In a double-blinded clinical trial, we compared the possible effect of gabapentin with a placebo in prevention and or diminishing episodes of HAMC in HD patients who had experienced frequent intradialytic muscle cramps. At first, placebo was given before each dial...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Beladi Mousavi SS, Zeraati A, Moradi S, Mousavi MB Tags: Saudi J Kidney Dis Transpl Source Type: research

Erythrocyte sedimentation rate in stable patients on chronic hemodiaysis.
The objective of this study was to assess the value and determinants of erythrocyte sedimentation rate (ESR) in stable patients on regular hemodialysis (HD). Pre-dialysis and post-dialysis ESR was measured in a group of stable adult patients on regular HD and the results were compared. The results were also correlated with the patients' demographic and laboratory data. Only stable patents were included in the study. Patients with evidence of current infection, active inflammatory processor malignancy and severe anemia were excluded. We recruited 161 patients in the study of whom 44.1% were males, 53.4% had diabetes mellitu...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Alsomaili MI, Yousuf M, Hejaili F, Almotairi W, Al-Sayyari AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Association of dialysis adequacy with nutritional and inflammatory status in patients with chronic kidney failure.
Abstract The number of patients with dialysis-dependent renal failure has increased in the past years worldwide. Several parameters have been introduced for the quantitative assessment of dialysis adequacy. The National Cooperative Dialysis Study results indicated that Kt/V and time-averaged concentration of urea (TAC) are predictors of mortality in patients who receive maintenance hemodialysis (HD). Also, the protein catabolic ratio (PCR), which is an indicator of nutritional status, can predict patients' mortality. Our aim was to assess the impact of parameters that show dialysis adequacy on indices of nutrition...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Hemayati R, Lesanpezeshki M, Seifi S Tags: Saudi J Kidney Dis Transpl Source Type: research

Lactate dehydrogenase as a biomarker for early renal damage in patients with sickle cell disease.
This study shows that in sickle cell patients LDH correlates with creatinine clearance and, therefore, LDH could serve as a biomarker to predict renal insufficiency in those patients. PMID: 26586054 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Alzahri MS, Mousa SA, Almomen AM, Hasanato RM, Polimeni JM, Racz MJ Tags: Saudi J Kidney Dis Transpl Source Type: research

Morbidity and mortality associated with Plasmodium vivax and Plasmodium falciparum infection in a tertiary care kidney hospital.
Abstract Malaria is a disease of tropical regions and both types of plasmodia, i.e. Plasmodium falciparum and Plasmodium vivax, cause significant morbidity and mortality. P. vivax was thought to be benign and cause less morbidity and mortality. Many reports showed the devastating effect of vivax malaria too. We compared the clinical symptoms, laboratory markers, treatment and outcome of both the plasmodia. This is a retrospective analysis of 95 patients admitted to The Kidney Center, Karachi in a duration of 15 years (1997-2012); 45 patients with falciparum malaria and 50 patients with vivax malaria, and compared ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Imtiaz S, Drohlia MF, Nasir K, Hussain M, Ahmad A Tags: Saudi J Kidney Dis Transpl Source Type: research

Profile of acute kidney injury after open heart surgeries in a tertiary care hospital.
Abstract Our objective is to determine the incidence, etiology, risk factors and outcome of acute kidney injury (AKI) after open heart surgery. A prospective study was conducted on 62 patients who underwent open heart surgery and were followed-up for the development of AKI and to determine its incidence, etiology and outcome. Post-operative AKI was considered when the post-operative serum creatinine was>1.5 mg/dL or there was doubling of serum creatinine above the baseline (pre-operative) with a prior normal renal function. The incidence of AKI in the post-operative period in our study was 17.7%. The common eti...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Rather FA, Najar SM, Malla HA, Ahangar AG, Bhat HM, Wani IA Tags: Saudi J Kidney Dis Transpl Source Type: research

Microalbuminuria and pegylated interferon in hepatitis-C patients.
Abstract To determine the relation between hepatitis C virus (HCV) genotype 4 and microalbuminuria in relation to hepatic histology and viremia in the absence of cryoglobulinemia and to examine the effect of treatment on microalbuminuria, we studied 400 HCV genotype-4-infected patients who were tested for microalbuminuria, albumin creatinine ratio (ACR), urea, creatinine and estimated glomerular filtration rate (eGFR). The parameters were measured again in the HCV patients after six months of treatment with pegylated interferon and ribavirin. Microalbuminuria was detected in 56 (14%) HCV-positive patients. There w...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Elshahawi Y, Sany D, Abd Elmohsen WA, Tantawi T Tags: Saudi J Kidney Dis Transpl Source Type: research

Adiponectin gene expression in human primary adipocyte culture treated with uremic serum.
Abstract End-stage renal disease (ESRD) is accompanied by an increased rate of morbidity and mortality due to cardiovascular disease (CVD). Although renal replacement therapy is required at this stage, it is associated with additional complications such as inflammation and dyslipidemia. It has been suggested that adiponectin has anti-inflammatory properties. We studied the potential role of uremic mileu on the adiponectin expression in human primary adipocyte culture. A cohort of 18 patients with ESRD (hemo-and peritoneal dialysis) and nine healthy controls were analyzed in a prospective cross-sectional study. Sin...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Alouffi S, Howse M, Sharma A, Ranganath L Tags: Saudi J Kidney Dis Transpl Source Type: research

Kinetics of parathyroid hormone after parathyroidectomy in chronic hemodialysis patients.
Abstract Secondary hyperparathyroidism is a common complication in chronic renal failure. The treatment in some cases requires parathyroidectomy. The kinetics of the parathyroid hormone (PTH) levels after surgery helps to evaluate the efficacy of parathyroidectomy. Prospective analysis was made of the kinetics of intact PTH (iPTH) after parathyroidectomy in 10 chronic hemodialysis (HD) patients who had secondary hyperparathyroidism. We determined the levels of iPTH before surgery and its evolution after parathyroidectomy at regular intervals: Day 0, D7, D15, D30 and D90. The mean age of our patients was 40 ±...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Skalli Z, Elouazzani H, Alhamany Z, Mattous M, Benamar L, Bayahia R, Belkouchi M, El Malki H, Ouzeddoun N Tags: Saudi J Kidney Dis Transpl Source Type: research

The correlation between attention deficit hyperactivity disorder and steroid-dependent nephrotic syndrome.
Abstract Nephrotic syndrome (NS) is characterized by nephritic-range proteinuria and the triad of clinical findings associated with large urinary losses of protein, hypoalbuminemia, edema and hyperlipidemia. More than 80% of children below 13 years of age with primary NS have steroid-responsive forms. There is no identifiable cause of attention-deficit hyperactivity disorder (ADHD). It is likely that the symptoms of ADHD represent a final common pathway of diverse causes, including genetic, organic and environmental etiologies. This case-control study was performed on 130 children aged between 5 and 13 years who w...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Yousefichaijan P, Salehi B, Rafiei M, Dahmardnezhad M, Naziri M Tags: Saudi J Kidney Dis Transpl Source Type: research

Outcome of upper limb vascular access for hemodialysis.
Abstract The aim of this study was to investigate the outcome of vascular access procedures for hemodialysis and factors affecting access survival and complication rates. A retrospective review was carried out on 276 patients who underwent 404 consecutive vascular access operations performed over seven-years. The overall primary failure rate was 9.2%, while the oneand five-year cumulative access patency rates were 63.8% and 40.6%, respectively. Diabetes mellitus status significantly influenced access survival (P = 0.022). Autogenous arteriovenous fistulas (AVFs) are reliable procedures with access sites often avai...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Alsmady M, Shahait AD, Alawwa IA, Riziq MG, Abusba AM, Al-Qudah A Tags: Saudi J Kidney Dis Transpl Source Type: research

Transfusion-transmitted virus infection in hemodialysis patients in Arar, Saudi Arabia: Prevalence, predictors and genotyping.
Abstract Transfusion-transmitted virus (TTV) is a single-stranded DNA virus that was identified in patients with post-transfusion hepatitis of non-A-to-G type. Patients with chronic renal failure on maintenance hemodialysis (HD) have a higher risk of viral infections, and the prevalence of TTV infection is common. The aim of our study was to detect TTV-DNA and its genotype in HD patients. A case-control study compromising of 63 patients on maintenance HD therapy at the Nephrology Center of Central Arar Hospital and 100 healthy individuals who were tested for TTVDNA and its genotype by semi nested-polymerase chain ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: El-Taher SM, Fouad NA, Fouad MA, Mahedy AW, Elnazi AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Analysis of histopathological pattern of kidney biopsy specimens in Kuwait: A single-center, five-year prospective study.
Abstract Glomerulonephritis (GN) varies in incidence in different geographical areas due to different socioeconomic conditions and ethnicity, genetic variability and environmental factors. Our study is aimed to determine the histopathological pattern of kidney biopsies in Kuwait over the preceding five years. In a prospective study, we analyzed the clinical and pathological data of 214 kidney biopsies that were performed during the period from November 2009 to November 2014 at the Al-Khezam Dialysis Center, Al-Adan Hospital, Kuwait. Kidney biopsies were performed percutaneously using an automated gun guided by ult...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Abdallah E, Al-Helal B, Asad R, Kannan S, Draz W, Abdelgawad Z Tags: Saudi J Kidney Dis Transpl Source Type: research

Immuno-histological assessment of sub-clinical acute and borderline rejection in renal allograft recipients: Data from a transplant center in India.
Abstract This single-center study was carried out on living related and unrelated renal transplant recipients (RTRs) to evaluate the usefulness of surveillance biopsies in monitoring stable renal allografts using immuno-histological markers for immune-activation. This is a prospective, longitudinal study. Protocol biopsies of 60 RTRs with stable graft function were evaluated at three, six and 12 months post-transplant. Immuno-histological evaluation was carried out using immune-activation markers (perforins, granzyme and interleukin-2R), phenotypic markers (CD-3 and CD-20), viral markers and C4d. The demographic a...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Badwal S, Kumar A, Hooda AK, Varma PP Tags: Saudi J Kidney Dis Transpl Source Type: research

Urinary screening for asymptomatic renal disorders in pre-school children in Enugu metropolis, South-east Nigeria: Useful or useless.
Abstract To evaluate the usefulness of simple screening tests such as urinalysis and blood pressure measurement in the early detection of renal disorders in pre-School children, we used a multi-staged random sampling method to select subjects from registered nursery schools within Enugu metropolis in south-east Nigeria. We selected 630 children for this cohort study. There was a prevalence of 2.7%, 0% and 1.9% for asymptomatic proteinuria, hematuria and hypertension, respectively. There was no age, gender or social class preponderance (P = 0.44). Hypertension seemed to be limited to children close to the age group of five years (P
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Odetunde OI, Odetunde OA, Neboh EE, Okafor HU, Njeze NR, Azubuike JC Tags: Saudi J Kidney Dis Transpl Source Type: research

Cross-cultural adaptation, validation and reliability of the South Indian (Kannada) version of the kidney disease and quality of life (KDQOL-36) instrument.
Abstract Health-related quality of life is an essential aspect concerned with the treatment outcomes. The main objective of the study is to evaluate the validity and reliability of the South Indian (Kannada) version of the Kidney Disease and Quality of Life-36 (KDQOL-36) instrument for hemodialysis (HD) patients. The KDQOL-36 instrument was validated by the committee of experts consisting of healthcare providers such as nephrologists (three), senior HD staff nurse (one) and clinical pharmacist (one). The measurement properties such as variability, reliability and validity were determined by administering the quest...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Mateti UV, Nagappa AN, Attur RP, Nagaraju SP, Mayya SS, Balkrishnan R Tags: Saudi J Kidney Dis Transpl Source Type: research

Scedosporium apiospermum causing brain abscess in a renal allograft recipient.
We present a case of renal allograft recipient who developed fever two weeks post renal transplant. He was initially found to have dengue fever. After five days, he became drowsy and developed right-sided hemiparesis. Magnetic resonance imaging of the brain revealed multiple irregular masses with associated edema consistent with fungal brain abscesses. Left parietal abscess was drained and he was started on voriconazole. His cyclosporine was stopped. Drained pus revealed fungal hyphae on potassium hydroxide stain and Scedosporium apiospermum on culture. Unfortunately, the patient died after five days. Scedosporium infectio...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Sharma A, Singh D Tags: Saudi J Kidney Dis Transpl Source Type: research

Fournier's gangrene due to perioperative iatrogenic colon perforation in a renal transplant recipient.
We describe the case of a male patient who underwent renal transplantation with complicated post-operative course, resulting in cecum perforation (thermal injury due to cautery use during transplantation) requiring exploratory laparotomy and cecostomy. A few days later, he developed Fournier's gangrene and urgent radical surgical debridement of the scrotum was performed, along with aggressive antibiotic regimen and the immunosuppressive treatment was modified. Subsequently, the patient underwent scheduled cecostomy closure (right hemicolectomy), while the scrotum trauma healed with tertiary intention. Epidemiologic charact...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Papadimitriou G, Koukoulaki M, Vardas K, Grigorakis A, Vougas V, Drakopoulos S Tags: Saudi J Kidney Dis Transpl Source Type: research

Wegner's granulomatosis developing for the first time in a patient eight years after starting maintenance hemodialysis.
Abstract Wegener's granulomatosis is a serious autoimmune disorder characterized by necrotizing small-vessel vasculitis. It is a multisystem disease that primarily affects the lung and kidneys. Previous studies indicated few relapses of vasculitis after hemodialysis due to uremic immunosuppression. Our case report describes an end-stage renal failure patient who had developed non-caseating lung granulomata with giant cell formation and fibrinoid necrosis of arterial media that is consistent with Wegner's granulomatosis for the first time and eight years after initiation of maintenance hemodialysis. We believe that...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Ali AR, El-Reshaid K Tags: Saudi J Kidney Dis Transpl Source Type: research

Dizziness and renal failure revealing the Von Hippel Lindau disease.
Abstract The germinal mutation of the Von Hippel Lindeau (VHL) tumor suppressor gene predisposes to the development of benign or malignant richly vascularized tumors. VHL disease is an autosomal-dominant disorder with complete penetrance at the age of 60 years. Screening for people at risk is strongly recommended, and careful monitoring allows treatment of the tumor lesions as early as possible. A 42-year-old man sought medical consult for hematuria, disabling dizziness and balance disorders lasting for two months. The neurological examination revealed the presence of a kinetic cerebellar syndrome. The cerebro-spi...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Sekkouri KA, Alaoui SR, Batta F, Belghiti KA, Alaoui H, El Fadil C, Arrayhani, Husseini TS Tags: Saudi J Kidney Dis Transpl Source Type: research

Meningitis and intracranial bleed in a child with steroid-resistant nephrotic syndrome.
We present such a case with raised intracranial tension in a 13-year-old child and discuss the management issues. Prompt recognition and appropriate treatment of these complications can be life saving in a child with nephrotic syndrome. PMID: 26586071 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Kapoor K, Saha A, Thakkar D, Dubey NK, Vani K Tags: Saudi J Kidney Dis Transpl Source Type: research

C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases.
Abstract C1q nephropathy is a recently described clinico-pathologic entity with a variable clinical presentation and pathology. Crescentic glomerulonephritis (GN) has been reported in only two patients in the available literature. CD59 deficiency, along with lack of CD55, is responsible for paroxysmal nocturnal hemoglobinuria (PNH). Few cases of isolated CD59 deficiency have been described with PNH-like features. A middle-aged adult male presented with rapidly progressive renal failure. Serological investigations were negative. A renal biopsy revealed necrotizing crescentic GN with rupture of Bowman's capsule. Imm...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Gupta R, Sharma A, Agarwal SK, Dinda AK Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury in a child: A case of Munchausen syndrome by proxy.
We describe the case of an unfortunate boy who had to undergo unnecessary hemodialysis for persistent hyperkalemia and azotemia before a final diagnosis of the falsification of investigations by the parents was made. PMID: 26586073 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Mantan M, Dhingra D, Gupta A, Sethi GR Tags: Saudi J Kidney Dis Transpl Source Type: research

Immunoglobin G4-related disease: Two case reports and review of the recent literature.
We report two cases of the IgG4-RD and review the recent literature about this increasingly recognized entity. PMID: 26586074 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Anandh U, Virarkar M, Shah A, Hastak M Tags: Saudi J Kidney Dis Transpl Source Type: research

Membranous nephropathy and severe acute kidney injury following influenza vaccination.
We report a patient who developed acute-onset massive proteinuria with NS and severe AKI soon after receiving the 2009 H1N1 influenza vaccine. Kidney biopsy showed membranous nephropathy (MN) and acute interstitial nephritis (AIN). Optimal management of glomerular diseases or AIN following influenza vaccination is not known. Our patient responded well to an initial course of oral corticosteroid therapy with normalization of serum creatinine level but had a relapse of NS with AKI soon after completion of corticosteroid therapy. A repeat kidney biopsy revealed MN and resolved AIN. A subsequent prolonged course of oral cortic...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Patel C, Shah HH Tags: Saudi J Kidney Dis Transpl Source Type: research

Everolimus with low-dose cyclosporine in de novo renal transplant recipients: A single center Indian experience.
PMID: 26586076 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Kesiraju S, Rao UM, Paritala P, Reddy VS, Sahariah S Tags: Saudi J Kidney Dis Transpl Source Type: research

Circulating bacterial DNA fragments in chronic hemodialysis patients.
PMID: 26586077 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Hazzah WA, Hashish MH, El-Koraie AF, Ashour MS, Abbass AA Tags: Saudi J Kidney Dis Transpl Source Type: research

Dialysatoma - A complication of continuous ambulatory peritoneal dialysis.
PMID: 26586078 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Ahmed S, Sethia RK, Gogoi S Tags: Saudi J Kidney Dis Transpl Source Type: research

Epidemiology of chronic kidney disease in a Pakistani population.
PMID: 26586079 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Ullah K, Butt G, Masroor I, Kanwal K, Kifayat F Tags: Saudi J Kidney Dis Transpl Source Type: research

Non-invasive screening tool for chronic kidney disease.
PMID: 26586080 [PubMed - as supplied by publisher] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2015 Category: Urology & Nephrology Authors: Saxena A, Gupta A, Abraham G, Sakhuja V, Jha V Tags: Saudi J Kidney Dis Transpl Source Type: research

Organ Donation and Transplantation in the Kingdom of Saudi Arabia 2014.
Authors: PMID: 26502480 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2015 Category: Urology & Nephrology Tags: Saudi J Kidney Dis Transpl Source Type: research

Response of transplant recipients to influenza vaccination based on type of immunosuppression: A meta-analysis.
Abstract Influenza vaccination is widely used in transplant recipients, but there is little known about the significance and correlating factors of its effectiveness. In the current study, we reviewed the existing literature on clinical trials performed in transplant recipients on the effectiveness of influenza vaccination and to evaluate the relevance of the type of immunosuppression employed in these patients on the humoral reaction to the vaccine. A comprehensive search of the literature was performed through Pubmed and Google Scholar to find reports indicating immunogenicity of influenza vaccination in transpl...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2015 Category: Urology & Nephrology Authors: Karbasi-Afshar R, Izadi M, Fazel M, Khedmat H Tags: Saudi J Kidney Dis Transpl Source Type: research

Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing Av fistula formation and their correlation with serum iPTH levels.
Abstract Vascular complications arise in uremic patients in the absence of clinically significant atherosclerotic disease. Elevated serum parathyroid hormone (PTH) and abnormal calcium (Ca) and phosphorus (P) balance have been implicated in vascular damage in chronic kidney disease (CKD) patients, but there is lack of histo-pathological studies. Patients with CKD stage 5 and 5D who underwent arterio-venous fistula were included in this study. Baseline and laboratory parameters including assessment of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric a...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2015 Category: Urology & Nephrology Authors: Tripathi V, Bansal S, Alok S, Ravi B, Devra AK, Saxena S Tags: Saudi J Kidney Dis Transpl Source Type: research